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<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y7</accession>
    <name>D4M6Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_00310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00310"/>
    <dbReference type="HOGENOM" id="CLU_1011041_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-13-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="275" mass="31189" checksum="DA83B713A5C113A1" modified="2010-05-18" version="1">MEKNGLKPDITSRENLFLDLTKAFESVASSEDRSGYNAALKELSSVLLEASQDGNALHALKLERQCIAVEQYLKETDSDILDKQLSRSGEAELSLKLVQDPKTYREHVESIFPNGIRGIPRGDGMYTFVSGQISYLGVGKRYFPAQEDARTEYYAARQANLRAGLEHFQELQREALFPEAVKLEKEIQELNLIEAPKIFVEPREDGQTYKGEIIHVNEEQGYCLQRIGSGLYVHRLDRLDVSPERGQNLKIAYARDGSTARVEPLVQKNKKTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z1</accession>
    <name>D4M6Z1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar hook-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_00350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1734"/>
    <dbReference type="HOGENOM" id="CLU_619293_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-17-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="376"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="442" mass="46860" checksum="75625B0236EEDF68" modified="2010-05-18" version="1">MNQALPSGGISGLTAVSGPTTGTATQFYVESKDHRLISISDVEGSLAKRMGIVNKASVVTIDVEETDTLTTIRNKINEKYQAELGITAPEEWVHASLKQDSDQSWYLTIASDVPGEAQRITLMGGADGNDQVLRRLGLMRLEQIGTVSATDKTPVYREVAAISTVAEDASFTFNGVRYLSSDNRFKEARRIPASGGSSDYSASKLAQVEEGMWFNLKHAGSTAITVRHHVRSGTIKALEEARDGIIPNLQGQLNDLTWGLVNHVNAYQYSGYGIGGDITTTGVAFFKPLGTRTRAASNLSVNDAVVADNALIGAAMGRKNAAGVAVSGVSGGSGDGSNALRMANLASARVLKGGTMTIRGVYDAMLSQVGSKAAHAQLMSTAQDSLAEQIGLQREAVSGVNLDEELMDMITLNRCFGAMSRYVTTVDEMLNAIINGFGLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z6</accession>
    <name>D4M6Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">SY1_00530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1950"/>
    <dbReference type="HOGENOM" id="CLU_033546_2_0_0"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="96"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="319" mass="34955" checksum="E4278C999768128D" modified="2010-05-18" version="1">MKDLKIFSGTAHPDFAKRICSELGVRLSAARHYRFSDGELGLSLDESVRGADVFVVQPTCEPANDNLIQLWIMSDAFKRASAYRVNAVIPYFGYARQDRKTKPREPITAKLVANLLTHSGVDRVITADLHAGQIQGFFDIPVDHLTGMPLLASYFRDSLSEEIPKGEVVVVSPDVGGVSRARSFAIMLKSDLAIVDKRRSHEVANVSEVMDIIGEVEGKTAILVDDIIDTAGTICNAAAGLKERGCRRVFACATHAVLSGPAMERIEKSVIEKLIFSDTIPMPEAKRSSRVQQLSIAPLFAEAIMRVHSERSVSSLFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M710</accession>
    <name>D4M710_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_00780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.234"/>
    <dbReference type="HOGENOM" id="CLU_012893_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-37-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="464" mass="50136" checksum="88B49E8476711C25" modified="2010-05-18" version="1">MLQPQRMGREPMLKLIFSFTLPSIAGMLANALYNIVDRMFVGRLVGTMGLAAISVCFPFMLLLLSLSLLFGIGAVPMISGALGEKNDDLAEAVLGSALAAAALVSVLVSVVAFIWMDPLLRLSGANEELLGPSREYLRVILLGAPFGMLSFVMNFAIRAEGRPNFAMATQVLGAVANIVLDALFVWGLKWGVAGAAWGTALAQLASLLWVASFYWRRLGHLRLRLQHCRLQPRLLGRLTALGFPSALTEVSFSLFYVLFNQSLAKYSGPLAVSALGAFMGWDSLLFLPVVGICDGVQAIFGFNWGARRPLRVLEALKLALILGTGYFMGSVVVVHFFLWDMMRLFSTDPELLTIAVVGGRVAYAGVIFTGVAMVTNSFFQGIGLSGLSLFLSLCRQFVFLIPALLIMPRIWGAIGVWGAFPALDAGGGALSILLLWGQCRRLGLLRCEARRLRLARLRRAGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M714</accession>
    <name>D4M714_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_00860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00860"/>
    <dbReference type="HOGENOM" id="CLU_007100_9_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-41-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="197"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="496" mass="51814" checksum="4FEBC0BEEDDF88B2" modified="2010-05-18" version="1">MDDRVLLLPILLPALAAAALPLRRFKGRTGFCAFAGGAVLSNSALLLYLAARPPVGTLTLLRLSHDLSLALRLDGAGAAFAALLACLCPFVALYGLGYMSRTPHRDKPFFVCFALAYGAAAGVALAANLTTLCLFCQLLILAVLPITRREGQRIAEVAFSLPLGWGVFCTLLSLAFATAFIGNVDFVPGGCLPADALRKPDLLYLIYLLGFLGFGLETAVLPLRGWPVASAEAPAPASALLNAVAVANAGVFAIIRLTWYVFGPDALNGSWAHLAAFALACVTTVYGACMALSSQRLKLRLAWSTIGQLAYVLLGTLLLTPSGLSAGMTQMAAHALIKANLYFCAGAILCQSGRRFLFDMRGWGFGMPATFLAFLLSALALVGLPPMAGFIAKWRLGIAAASAGASSPIGFFGLAAMLTSALLTTFYVLQVLCVAVMPGRGFNLRAANYGITDPGPAMLIPIGLLAASALLLGLWADPVLGFFERAVPGTLPEAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M755</accession>
    <name>D4M755_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_01470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01470"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.664"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-82-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="329" mass="38003" checksum="A7B33C20BE8FDF9F" modified="2010-05-18" version="1">MFHYANYIYAVYRERSFSKAADKLFITQPALSIMIRKAEEELGLPIFDRSHNPIGLTPFGVEYVQALKEIHAIEQRLRELIEQTRTLQRGHLSIGSSNLCVDYFVTRHLVQFHRQYPNVDLTVRNLNTLDAKHLLDLGELDFVITNRPYDDKKYVQKVCFRECLILVVPSDFEVNKGLEAHCLAPEELGDTVFSLPGRRTVSLSLFAQVPFILLSSQNYLRQYTDFLFRERNISPTILLELEQSATSYNFANLGMGATILSNRLIQNNADTTKLCFYKIDSDHADRDTFLSFRRGVYFSDAMRRFAELFLEAHSVVDDESMENLSSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M769</accession>
    <name>D4M769_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01660"/>
    <dbReference type="HOGENOM" id="CLU_1076691_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-95-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061140" evidence="1">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="258" mass="28616" checksum="F79C2F9B4E7A99DE" modified="2010-05-18" version="1">MMRKIFPALAALLLFAALTAVAGAEAVEQRAFALKDPVTLYAKPDESAKSWEVSLPDEGVKVPSAIRDKDDALWYKVTVDGRTGWLFNEGIRLLMGGKSRVAESVYKRCAGVRSRVMKKPGSAWQEGTTTDETDGTLVTYTTEGGAFQALKTGDGVEDVYFCANGSEACKTFLGFDPIDMHKDKLRAKVGTPTVRETPDGERDVSILSYELGNRRMTMAFHLRNDRVEWFELYRGRTGEAAEGWSLEAIRAREEARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M798</accession>
    <name>D4M798_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator with C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02130"/>
    <dbReference type="HOGENOM" id="CLU_1832259_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-126-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="140" mass="15540" checksum="85AD45A5490187A2" modified="2010-05-18" version="1">MASIGANIKARRRALGMNQEELARKLGVTQANISRIESSVKGLSSDMLLPIASALSCDVRELLGLKCDDRTELSALGEDARTFVTRTLENDPQLALYLRSFVKDQDSFTEEDWKFLASSLRLALGYAVDAIKTRRVRDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A4</accession>
    <name>D4M7A4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="2">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_02230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02230"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1634"/>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-132-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="460" mass="50077" checksum="3F645B464113F194" modified="2010-05-18" version="1">MSKRNVPYIPNSDPAIQAGMLKAIGARSIDELIERNIPKELLMKEPLKLPAPFTAEGDLVRHVSAILDKNRTAQELTCFLGAGCWNRYVPALVDEVIGRSEFLSAYAGEPYEDHGRFQACFEYESMMAELLDCDVVNVPNYDGSQAAGTSLRMATRVTKRDEVLVTAALNPDVLQAVRTYLDPDVALTLVDYDRRTGRVDLADLEKKLSHKAAAVLVMNPNFFGIVEEEAEEAARMAHGAGALFLVYAEPSLLGVMKPPFQYGADIACGDIQGLGIHMNYGGGVAGYIASEDRPEIVREYPSRLFGLAPTTHGEWGFGDVMWERTSFANRDHAKEFVGTHAALWSIAAAVYLASMGPEGMRELGQTILQRSLLARRRLASVPGLTVCPLSGTPFAEFVVRFEGRSVAEVNEALLARGILGGYDLGAKFPELGQCALLCVTERTTEEDIDGLTAALTEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B3</accession>
    <name>D4M7B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02320"/>
    <dbReference type="HOGENOM" id="CLU_2824860_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-141-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="66" mass="7648" checksum="38D200DB27499B93" modified="2010-05-18" version="1">MEVLNMAANAPEQRVMSVSPRRIAAMVNIKTANLNREEAKKLMLDEMAERFDEAWAQQEKWKEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C0</accession>
    <name>D4M7C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02430"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-150-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="186" mass="19844" checksum="DB6E797302FDD8A9" modified="2010-05-18" version="1">MASAAVFLIDGFEETEALTTVDILRRGDVEVTTVSLTGRGDAVSSRGVSVRADALFDDAKDKDFDMLVVPGGTVEYARHEGLRTLVQKYDAAKKRLAAICAAPLALERAGVLKDRRAVCYPGMEPQIPSAILGTENVVTDGHVTTAKGPAITPFFALKLLELLCGKERADEVAKDFLIPLIGGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F3</accession>
    <name>D4M7F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenium metabolism protein YedF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_02870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02870"/>
    <dbReference type="HOGENOM" id="CLU_097491_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-183-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019870">
        <property type="entry name" value="Se_metab_YedF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03527">
        <property type="entry name" value="selenium_YedF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="197" mass="20508" checksum="918495EB20EB7493" modified="2010-05-18" version="1">MITINAMGKACPEPVIMTKAALEKGATELEVLVDNAVAASNVTRLLEGQGFQVERRENAGEFRLTGRRDGAAAATAPASASCPQSGARLAVLVTGKTLGREDKELGEVLIKGFMGTLSKLGTPPAVLALMNEGVKLALPEASTCDHLKDLEKAGTRVLVCGTCTNHFGITEQVGVGTVSNMFEILEAVTGADRILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F7</accession>
    <name>D4M7F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-Dimethylarginine dimethylaminohydrolase</fullName>
            <ecNumber evidence="4">2.1.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_02940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidinotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.4.1" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02940"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1774"/>
    <dbReference type="HOGENOM" id="CLU_047415_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-187-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015068">
        <property type="term" value="F:glycine amidinotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033195">
        <property type="entry name" value="AmidinoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488">
        <property type="entry name" value="PTHR10488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633195-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="383" mass="43732" checksum="C1026B222DC9FA28" modified="2010-05-18" version="1">MPKVVNSWNDFDPLKHVIVGRADNCCIAPSEPASKAKVPLDSPMRGMTGPRPLDTVEKANAQIEHFVKELEKRGVKVDRPEPMQWNQAVVTPHFMTGSMFGCMPPRDVLLTVGSDIICAPMSFRSRFFEYLAYSKVLRRYFDEDPDFRWIAAPRPELGDASYDMHYYDGHITEEVLLERTAKLEMVTTEHEILFDAADVMRVGKDFFIQHGLTTNRKAMEWIRRMYPECRIHAVNFPGDPYPIHIDATFVPLRPGLILNNPQRKLPEEQRKIFEANDWQIVEAAMPAHKEPPALCYSSVWLSMNCLVLDHKTVFVEASETAQMEQMDKLGMNVIPIPFRDAYPFGGGLHCATADVYREGGCEDYFPKQVKDVTLVEFGKMKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J1</accession>
    <name>D4M7J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_03570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1839"/>
    <dbReference type="HOGENOM" id="CLU_130332_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-221-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="101" mass="11211" checksum="DDA4F3246A8E9BF0" modified="2010-05-18" version="1">MTIMPERTPGAAALNEEKRAALKALKTVRGQVEGIIRMIEEGRYCVDISNQLLASSALLRRANVLVLRQHMHHCVRDAVEHGDVDAKLDEISDLLAKIIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J4</accession>
    <name>D4M7J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein related to dihydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_03600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03600"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1842"/>
    <dbReference type="HOGENOM" id="CLU_050509_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-224-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAP_DH_C" evidence="2">
        <location>
            <begin position="141"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="366" mass="39199" checksum="32C8A038954E01C8" modified="2010-05-18" version="1">MRDIRVMIWGFGAMGSGIARMLLKKTGVEIVGVVVGRKHLHGTDVYQYLGEERGSRPELLFGGTELIRNGACDVVLLGTDSFTRSAFEKVKLCVEHGLNVITTAEEMAWPWAQEPELSLEIDRLARQHGVTVFGTGINPGFVLDLLILAITGTCEDVKSIEAARINDLSPFGGAVMHEQGVGITPEEFKRRLAANDLAGHVGFPESISAIAAGLGVEITKIEQTKDPIISKVHRETPYAKVEPGNLAGIRQQGWGRTADGRAFIHLDHPQQVRPEAEGIDTGDYITIDAGGYTLKFSGKPEMPGGIGTIAMVVNMIPQVLNAPAGADRPSGAPDPARDPGRHEPVRPRAAGGAPRLPQGGLRRAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K4</accession>
    <name>D4M7K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_03800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03800"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-234-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="255" mass="28638" checksum="DD29226D50B5C240" modified="2010-05-18" version="1">MIKESDLLRIEGLAKHFTSDQGRDVVALSDVNLSVKENEFVCIVGPSGCGKSTLLRILAGLELPSGGRALMKGVEIKGPGRERGMVFQEYSLMPWRSVEENVWMGPELLGRPTEERKAVAAHYIELVKLSGFERAFPHELSGGMRQRVAIARALMNDPEILLMDEPFGALDSHTRIILQKELLKIWQAHRKTILFVTHSVDEAVFLADRIVVMSARPGRIILEEPLDLPHPRRRDNAVYARTLENILTLLEAEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M2</accession>
    <name>D4M7M2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_04070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04070"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1890"/>
    <dbReference type="HOGENOM" id="CLU_027579_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-253-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL27867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="396" mass="43450" checksum="5533AD23F1BD622A" modified="2010-05-18" version="1">MENRDACPRKAEPVLPRGARPSLYLHVPFCAAKCGYCSFYSRRAGDGEVAAWLDALEAEARAWRDRLGGRVPPRTLYVGGGTPSLLTPGDWRRVLRILEVMADLSPLEEASVEANPSSLTKEHLAVWRDGGFTRVSLGVQSLDDGELRRIGRLHDAAGALRAMAMVLGAGLHLSVDLIFGLPGQTLRSWSASLRGVLAAGVGHLSTYQLTLEPDAPMSRQSLSLPDGYPLYRYAQWFLAKNKFLQYEISSFAPSGAECRHNLAYWRQEPVLPLGPAAWGYLDGWRWSNPPTLEAYLEAARCGFPDPLAGAERLSPRARALEAAILALRTRWGIDRLEFARRWGTGVLREVEGVLLGLPPRLLRTEEGALALTPSGMRVGNAVWTELMALEDRGAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M4</accession>
    <name>D4M7M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_04110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04110"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1896"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-255-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="37061" checksum="726455E73E7394AA" modified="2010-05-18" version="1">MSDILLEVKDLRTHFITGENMVKAVNGVSFSVRRGETFGLLGESGCGKSATCRSITRLINPPGQIIGGEILYEGTDLLKLPMDKLRRLRGREISMIFQEPMTALNPVLPIRTQIFESLDPQMSRAQKRARALELMHLVGIPSPEKRIDEYIHQFSGGMRQRVMIAIALASQPHLLLADEPTTALDVTIQDQIMKLIGGLKKRMNMSVILVTHDLGVVSQMCDRVAVMYAGHVMELCDTVTLFFHPRHPYTHGLFRSLPYGKGTRTRLEPIAGAPPSLENLPAGCPFEPRCDWAEECCRAGLPPLTEIAEGHFTRCYFYAKLPDEVRFSTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M9</accession>
    <name>D4M7M9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ORF">SY1_04200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04200"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1907"/>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_0"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="52"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="283" mass="31961" checksum="2060817DBF8ED286" modified="2010-05-18" version="1">MTEPRAAMRKPEWLKIKVQGGRPFQEVEALLKALHLNTVCQEANCPNRMECYGKRTATFIILGRNCTRNCTFCNVSRERPDPVDPLEPEHVAAAVRSLKLRHAVITSVTRDDLPDQGAGQFAACVRELRAQCPETTVELLIPDMQGREDLLDVILAERPEVLNHNVETVPALYPRVRPQADFERSLGVLRYAKSKGFKTKSGIMVGLGEREDEVIDVMRRLREGDCDMLTVGQYLQPTARHIAVHEYVTPETFERYRIEALELGFARVASGPFVRSSYKAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N0</accession>
    <name>D4M7N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04210"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1908"/>
    <dbReference type="HOGENOM" id="CLU_069579_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-261-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="354" mass="39686" checksum="CA87EB2E3993846F" modified="2010-05-18" version="1">MPLEIVRNDITKMKVDAIVNAANSSLLGGGGVDGCIHRAAGAGLLEECRTLGGCETGSAKITGGYGLPCRYVIHAVGPVWRDGRHGERDLLASCYRTSLELAKEHGCESVAFPLISSGAYGYPKDRALRVAVDTISEFLFRNDMTVYIVIFDRRAYQISAKLFRDVAEYVDDHYVEEHADRNEAQRRRRSFPEWEAELLRSAEVLEDLDEVHECVPRDPARKRGPMSPAGPLKDLDEVVSRIDESFSRMLLRKIDEKGMTDVECYKKANIDRKLFSKIRSDVDYRPSKPTALAFAIALELPLDEAKDMLMKAGFALSRSSKFDVIIEYFIRNGNYNVFEINEALFAFNQSLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N3</accession>
    <name>D4M7N3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-galactose-binding periplasmic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-galactose/ D-glucose-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_04270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04270"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1914"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-264-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01539">
        <property type="entry name" value="PBP1_GGBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044085">
        <property type="entry name" value="MglB-like_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003060999" description="D-galactose-binding periplasmic protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="9">
        <location>
            <begin position="30"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="336" mass="36344" checksum="D06D8A2617767F29" modified="2010-05-18" version="1">MKKWALCVGTVLVLGLAVSAMAADVLVGACIYKFDDTFMTGVRNAMNAEMKEHSGSLEIVDSQNRQPDQNNQVDTYITKGVNALIVNPVDRTAAAPLMLKAKAEGLPIVFVNREPQEEVMKSYDKTWYVGAKAEESGTLSGQIIADYFKANKAADKNGDGKIQYIMIRGEQGHQDATLRTEYSVKAMKDSGFELEELGSDTANWDKVQGANKMSGFISAVGLDRIEAVLANNDDMALGAIEALKAEGYNAGDPAKFVPVVGVDATAPALEAMKDGSMLGTVLNDAVNQGKAAVRVAVAAAEGREVTKESIGYDVTDERYIWIPYRKVTSENYKEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P9</accession>
    <name>D4M7P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Site-specific recombinases, DNA invertase Pin homologs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_04520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04520"/>
    <dbReference type="HOGENOM" id="CLU_010686_8_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-280-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="210" mass="23949" checksum="DCF1F2E0E53DF9A7" modified="2010-05-18" version="1">MVYGYMRISTGDRTVDVQRDALVSAGIPEENIYSDTITGSTRISRRPEFEKLRERLRQGDILVVWKMDRLGRSILDLITTVFDLLDRDVTVRSITDAVDSSTPQGRALFGILDTIADLERENVRERVRAGMRAARQRGTHCGRPRMANREMAEAIREHLRRDASVRDIARQLNISVSLIYKVLREFPDQDAEPAPPMPEETEDGPELMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q3</accession>
    <name>D4M7Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04660"/>
    <dbReference type="HOGENOM" id="CLU_3396664_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-284-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="31" mass="3565" checksum="4983A5103E88259C" modified="2010-05-18" version="1">MKPETGILLFVGGMMMCMGMMMRMYTMDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q5</accession>
    <name>D4M7Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type metal ion transport system, periplasmic component/surface antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_04690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04690"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1962"/>
    <dbReference type="HOGENOM" id="CLU_067080_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-286-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061737" evidence="5">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="276" mass="30058" checksum="1EBED257CBF8593E" modified="2010-05-18" version="1">MKRVFFAGAILVAFLGLTGAATAAQTVKLGVVGSLYEDMWAPAKEELAKEGIDLELVHFSDYVTPNRALSDGEIDLDGFQHDIYLQNEIKEYGYRLTTVGSTFIIPLNLYSRKVKSVADLKDGDVIAIPNDPTNGGRALKVLAAAGIVRLKDGASFSPTKEDIEEYKVKVEISEMAANTIPSVLPDVAAAIINCGYAMDFGLTAEDVLFNDTSVSDREYWNIIVARTADLEDPAKVELFRRIVKAFQSPATKAVFDGKFGGQFLPAGWGEDLLKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S0</accession>
    <name>D4M7S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA-like transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_04950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1988"/>
    <dbReference type="HOGENOM" id="CLU_033863_20_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-302-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="162"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="315" mass="33422" checksum="1E923F6A3457489A" modified="2010-05-18" version="1">MKEVHIDCGAAPSAEGKMARRDVLLLLAVAVVWGVNFAVVKTGLRSVPPLFLVFLRYLFIVLPLIFFVKKPAVSWRTMAAYALLSGVGQFSFMFYSLKIGMPAGLASVVMQSQAIFTLILSAQFMGERIGGAQLAGIGLAAVGLGLIGGPFGAAAVPTAAFLMNLLAAFCWSSSNLIVKRASEESLRSGRSLDMMEMIVWSSIFVPLPMLGLSLVGDGPSAILQSLAQIDAAAVLSVLYLVVLSTLFAYSAWNQMIAAYSAGRVAPFSLLVPVTGLLSGMLFHEERVAPLQWAGIAAVVAGLAVFQLGERRPHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U7</accession>
    <name>D4M7U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subtilisin-like serine proteases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_05330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S08.091"/>
    <dbReference type="KEGG" id="sbr:SY1_05330"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2026"/>
    <dbReference type="HOGENOM" id="CLU_011263_15_6_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-329-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061164" evidence="4">
        <location>
            <begin position="24"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="152"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="523" mass="54348" checksum="0B4BBC30F8114FEB" modified="2010-05-18" version="1">MRKVFLRLAALAAACAFAGPAAAARHVPGEVLAVFKGEEGTKVVASSLHLGREAFRAASLAAAVGARVEETYAELSEAGNGVFVLLKSDILSPEALTARLLKREDVLAASPNFIVRASVTEPNDPFYASGALWNLKAIRAPEAWDTTTGRGDVCVAVLDTGVDYTALELAPNFRRDLSRNFYKDGGTSRADPEAYADRNGHGTHVAGTIGAAGNNGRGVTGVNWSVGLISLRTLGPDGSGPVSGIVDALNFLTKRLEEDASLKVAAVNLSFNWFSSMPPTLANQRKDPVWRAFKALDSLNRTVIVTSAGNDGLEVGVLAPADGPKGADGTPTYERGDYVYSSSYRGIHNLIVVGASSQNGSLANFSNWSRNFVDVAAPGVSILSTTIAAYEHSTRVGDGTVMATMNGTSMAAPHVAGAVALLKAADPARTAYQVRTALLHGAAVKSVLVGKVAGGRFLDLKGALDYQAAHPELASEAPRTEYDERIKDADGTSSSGGAGCDAAGLGALGWGLVALLAVVGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V2</accession>
    <name>D4M7V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05390"/>
    <dbReference type="HOGENOM" id="CLU_3418929_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-334-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="25" mass="2902" checksum="EDDF66BF5A9B9E07" modified="2010-05-18" version="1">MMTFRVEDATAVDITIIDEVENLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V7</accession>
    <name>D4M7V7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsU</name>
        <name evidence="7" type="ORF">SY1_05440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05440"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2035"/>
    <dbReference type="HOGENOM" id="CLU_159258_3_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="65" mass="7699" checksum="CA6332320F3CC3E1" modified="2010-05-18" version="1">MTTVTRKEGENIEDTLRRFKKEVAKVGTLREARKREHYEKPSDAKKLKRAEAARKRKSMRRRNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W1</accession>
    <name>D4M7W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/H+-dicarboxylate symporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_05530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2045"/>
    <dbReference type="HOGENOM" id="CLU_019375_7_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-343-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="445" mass="47099" checksum="8F91929051FBE2D5" modified="2010-05-18" version="1">MKGKTTIVHKMLIALVCGLAVGIGCLFLREYLLSNGGEGTWKLINGLLFQDITRPEGVRSLGLFYIIGQVFMNGLQLAIVPLVLVSISLAMCSISEAAKLGRIAIRSLIGFLGFYAVGCLIAGAIAYGARGMGWFTVVLPGGEVTKTAQIAPYNPLGVIVDAIPNNIINVMGVNTRILAVVVVAVILGICMNKLGEKAHVLKSVLEGLSDVINMWLTFLLNRVGPFAIFCMISRTFAVYGVEYLKPAAAYMGTAIFTLFLVLLTVYPIGILLLTGLNPFKFIKKMAKVGVFGFAMNSSAATLPINMRTNLDELGCSEEITSFVLPLGMTINMNGTSIMHMVAVTFIATSAGIPITPATLVIMAVLTICAAAGTPAIPVAGTTMIFTVMAGLGFTTEACLVGYALVVAINRPVEMSLLTLNVIGDAAVNVIVNAKEGELNRDVYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W4</accession>
    <name>D4M7W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_05570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2050"/>
    <dbReference type="HOGENOM" id="CLU_020207_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-346-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="244" mass="27862" checksum="A153A6EE4AACFA59" modified="2010-05-18" version="1">MQDVAIKQAGDSAVLVEFENEIGIETNAKVRSLMFSLERRPFAGMRELTPAYRSLLIQYDPCAVKSGAVREFVGQSLANLRSVTLPKPVITEIPVIYDPEFAPDIEEIARIEDKTVEEVIRIHSGSDYFVYMLGFAPGHPYTARFENPFSFKRRESPRVRIDGGSVVVQLALSNIIPFDQPCGWNIIGTTPVLVCDYRRENPFLLKAGQWIRHIPIDRDEYFDIKRRVELSEYVCRTYEKEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X4</accession>
    <name>D4M7X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalt transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_05730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2065"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-356-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="266" mass="28894" checksum="DE2FC5B8B40E337D" modified="2010-05-18" version="1">MSSANGVMEGLRDIPVGGVRKRYLMEVQDLRYAYPDGHEALNGVFFVLRDGEKLALVGPNGSGKSTLMLHLSGCLAAQSGVVCLNGEPVGEDLKRLRSAVGLIFQEPDNQLFMPEVVEDVAFGLVAHGTPVQEAQERALSVMETLGIAHLAERAPHRLSGGEKRMAALAGILVMQPDIVVLDEPSAALDPRARRRVIERLNTLEKPMILATHDLDMALDVCDRAIILYEGRIAADGALQDVLRNEALLQQNGLELPLRYTKSTEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y5</accession>
    <name>D4M7Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ORF">SY1_05900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05900"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2080"/>
    <dbReference type="HOGENOM" id="CLU_018868_3_0_0"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="89"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="215"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="442"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL27980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="668" mass="75195" checksum="DCCE2F9D3D60FDE9" modified="2010-05-18" version="1">MAVDERVTLSLDFPDGLPALPKFDPQYRRAPDRGYTLNEKETVLALANALRYIPERFHRELAPEFLEELRTRGRIYGYRFRPEGKLWGKPIGEYRGRSAEGRAFQVMIDNNLDFDVALYPYELVTYGETGQVCQNWMQYLLIKRYLENLTQDQTLVVESGHPLGLFRSRPEAPRVVVTNALMVGLFDNQEEWHRAMQLGVANYGQMTAGGWMYIGPQGIVHGTFNTVLNAGRKKFGNKPDVLKGRLFVTSGLGGMSGAQPKAADIAGCVSITAEVDESRIRTRHDQGWVQEVCRTPKEAFDRAREQMKKDDVHSIAFHGNVVDLLQYAVDQGIGIDLLSDQTSCHAAYDGGYCPAGITFEERTRLLKEDPARYRTLVDETLKRHFHLIKTLVDRGTYFFDYGNAFLRTVFDAGVTEIAKNGKDTYDGFIFPSYVEDIMGPMLFDYGYGPFRWCCLSRDPEDLRRTDRAAMDCIDPERRQQDKDNWVWIRDAEKNALVVGTQCRILYQDAEGRVRIALKFNEMVRNGEIGPVMLGRDHHDVSGTDSPFRETANIKDGSNVMADMAVQCFAGNAARGMSLVALHNGGGVGIGRAINGGFGLVLDGSFRVDDVIRSAMSWDVMGGVARRAWARNEAALETSAEFNKKRTGEHITLPYLADMDYLKDLVAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>D4M849</accession>
    <name>D4M849_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysS</name>
        <name evidence="10" type="ORF">SY1_06850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2178"/>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="190"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="511" mass="58371" checksum="7F4E6C192500163E" modified="2010-05-18" version="1">MENAVKGPGQGGLEQEGADNEVVRQMKEKLLRLRREEGFDPYVAETWDCRDHLADVRCRFEHLAPEESDETVTLSTAGRLMTLRRQGRTTFADLADETGRIQLYFQVNALGEKPYEFLKKWVDTGDWLGVVGHPCRTKRGELTIQVTDYKLLSKSIRPLPEKWHGLTDTETRYRRRYMDLIANPEVREVFRKRSKIISSFRETLEAHGSLEVETPILSVLAGGANARPFKTFHNALGLDMYLRIAVELYLKRLVVGMMGRVYEIGRNFRNEGIDTMHNPEFTMMEVYWPYANYEDMMNLAEELIRNAAKAIGTLEIEWNGVKADLSRPFRRITMLDAVKEYAGVDLSAVTDDEAARKIAREKGLGGDLKGTESRFAVLNLLYEAFCEEKMVQPTFVMGHPTEISPLSKRDPENPDYTHRFELFMFGKEVANAFSELNDPLDQRARFEDQMRKKEAGDDEAHAFDEDFINAIEVGLPPTGGMGIGMDRLVMFLTGARSIRDVILFPAMKPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M856</accession>
    <name>D4M856_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06980"/>
    <dbReference type="HOGENOM" id="CLU_3099135_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-439-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="51" mass="5657" checksum="4C8C764E9EB18FAA" modified="2010-05-18" version="1">MAEMIFCIWAGVWLIATGVMYRIAVKREYDTYGVKGWNSPGTGLNSPTEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M873</accession>
    <name>D4M873_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_07320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07320"/>
    <dbReference type="HOGENOM" id="CLU_174551_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-456-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="109" mass="11957" checksum="62486027A189FF71" modified="2010-05-18" version="1">MADNPTIAEIKAAEERAAAGVQDAKSAAARRLNQARTDAESTLKETRQSAARQFREKLHRAEEAAEIKAKDILSKREADAKAFYAKHKDKVAGAASWITEEVMGRYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M879</accession>
    <name>D4M879_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atpB</name>
        <name evidence="6" type="ORF">SY1_07400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07400"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2228"/>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="4">
        <location>
            <begin position="132"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="469" mass="52301" checksum="F55D7F3B889F54C6" modified="2010-05-18" version="1">MLPKEYRTISNISGPLMMVESTRDVRYDELAEIELASGERRRGRVLEIESDRALVQVFEGTSGIDTNETKVRFLGKVQTLPVSRDMLGRVFNGRGEPIDGGAPLIAEQTLDINGMPMNPYSRDFPSEFIQTGISTIDGLNPMVRGQKLPIFSASGLPHNRMAAQIARQATVISGHEDFAVVFAAMGITFEEASFFMEDFRKTGALERTVLYINLADDPAIERISTPRIALTAAEYLAFECGMHVVVILTDLTNYCEALREISAARKEVPGRRGYPGYLYTDLATMYERAGRLKGKVGSITQIPILTMPEDDKTHPIPDLTGYITEGQIILSRSLHRQGIYPPVDVMPSLSRLKDKGIGKDKTREDHADLMNQLFAAYSRGKDAKELAVILGEGALSDEDKAFAKFSDVFEDTYIRQGEYENRTIQETLDLGWNLLTMVPTKELKRVRDAYIDKYLKPLLEKKAAQGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M889</accession>
    <name>D4M889_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07540"/>
    <dbReference type="HOGENOM" id="CLU_1370440_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-474-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061182" evidence="1">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="199" mass="23059" checksum="454FE5C293CBC9E0" modified="2010-05-18" version="1">MRRTVRFFLWAILLFCLLFPAGMALAATKVQIVEYQCRVCDKIFYGFKGDKLDDDIFMKQDVQLARMSKLSDRGKPLDPCKGGMKSHILDKKREGEATMEFISQNLDKFVVLKGSGSVHGTLKEWECFMCKKPFYSLNKEDLNIKEWDEQQNYLFSLKGKKPISRCKEGYQGHVFMPKKEGSFSSSELAIVVYDLFWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M891</accession>
    <name>D4M891_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase DDE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_07570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07570"/>
    <dbReference type="HOGENOM" id="CLU_073820_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-476-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="132" mass="15292" checksum="408B010421B2D244" modified="2010-05-18" version="1">MHTLKVQIVADASTRDILCISVGKGKQHDFKMLEESKVHFSPRIQVIADKGFQGLKKLHTNSVMPIKAKRGKQLSALEKIYNAVVSKCGIYIEHINRYIKRVRIFSSRYRNRRKKFALRFSLICGIYNFQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M896</accession>
    <name>D4M896_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_07690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07690"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-481-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="295" mass="33071" checksum="C959214C72327F4D" modified="2010-05-18" version="1">MESTFNRYEVFLKVAELGNITRAAEALNYTQSGVSHSIAALEREAGFPLFLRGSGGVALTERGRRLLAPVQELVNRQRNLAQAIHEINDVVCGTLRLGTFTSVSAQWLPWIIRDFQRSCPRVEFDLRAGDYDEIGEWIRREKIDCGFLSAPVPEGLSFRPLKEDPMKVILPVGHPLAERGSLTLPEIAQEPFIIPMKGSDNDIQALLRRSGVSVRVRYALNDEFSVMSMVEHGFGVSIMPDLILRNFRFSLLSRDLSPEAHRTLGIASLPPERVSVVGRTFIRYLSGPAVDLWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E5</accession>
    <name>D4M8E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein with conserved CXXC pairs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_08410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08410"/>
    <dbReference type="HOGENOM" id="CLU_148086_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-538-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="122" mass="12695" checksum="61E3910C2EC9CE60" modified="2010-05-18" version="1">MTRERKFICVSCPLGCGLTVALDGDAIVSVSGNSCPRGKTYAESEVKNPCRVFASTVRVKGGRLPVCPVRSRTPAPKGKLLDIARAVGELEVPAPIAIGQTILKGACGTDVDIVASRDLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K0</accession>
    <name>D4M8K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09350"/>
    <dbReference type="HOGENOM" id="CLU_068890_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-593-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="155" mass="17271" checksum="43A1C98FC4C2E6AA" modified="2010-05-18" version="1">MKTLIVYFSKSGRTRKAAEEIASLLEGADLFEIKVDKTYPPSYFKTLFEGRREFKSGERPRLAVMPPDPAPYDRVLLGWPVWFGTCPMAVISFLEACDLSGKEVYPFCTSSMTGPERGVRDIAAACRGHVHKGLRVRRADAERIAAWLDAPAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8L9</accession>
    <name>D4M8L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="10" type="ORF">SY1_09610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.163"/>
    <dbReference type="HOGENOM" id="CLU_050012_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="288" mass="31689" checksum="899756BC0BBA4753" modified="2010-05-18" version="1">MNRNYNFMALRRPALSLSAVLVLASLAFLFTRGLNLGIDFTGGNVIQLEFDNLPEVAEVRKVVSGVVAQEAMIQKFGEKGVIIRTNEDTEESREQVISVLQKAFPDMKVSGYEKVGPVVGGELRRQAVIGVSIALVAILIYITVRFRFRFAVVSVVPLVHDVLIALGFFSLTQMEVSSSFIAAILTIVGYSLNNTIIILDRIRENWRDLGRDGIEKLVNDSVNQTLARTINTTLTTLFPVIALCVWGGPVLQAFSYAMLVGIIAGTYSSMLVATGALIEWYKARPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M9</accession>
    <name>D4M8M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/H+-dicarboxylate symporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_09820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09820"/>
    <dbReference type="HOGENOM" id="CLU_019375_7_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-623-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="419" mass="44343" checksum="732CB51601D5DD76" modified="2010-05-18" version="1">MPKRESVFQNYALLIAMLGAIAAGCAVGWAWPGAAALEPLGTVFINLLFCIVVPLVFCSVAGAIANMKSRARAGKIMGVTIATFVVTGAIASVITIALMKLYPPVPVPWTELKAAEVGDQASLATLVVNFFTVPDFSALLSRRAMLPLIVFSILFGFGVSMAGGPATLTARALADMTECMLKVIKLLTYYAPIAFFGFFASLVATYGPQLIGDYSRALVVYYPLCFVYILTAFPLMAWFGGGAAGPRVMFRHILKPAVTSLGTCSSIATIPANMEAADDSGISRDITEMVLPLGATMHMDGSCFSCTLKIAFLFGVFGMEFSGVDTFLRVILVSVVSSVAMSGIPGGGYIGEFVLCSLFFPDHLPLAYPIAITIGNLVDPPATMINASGDYVASFIVSRFVDGRDWLKNALARKASEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P6</accession>
    <name>D4M8P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10050"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.208"/>
    <dbReference type="HOGENOM" id="CLU_114047_10_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-640-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="70" mass="7752" checksum="5F8B7AC7F9224A5D" modified="2010-05-18" version="1">MATHTFTAVIHREDDWYVAECPEVGTASQGATLEEAIANLREATELYLEEEAYTPRGRPLVTTFEAVAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S3</accession>
    <name>D4M8S3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Signal peptidase I</fullName>
            <ecNumber evidence="3 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_10590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S26.025"/>
    <dbReference type="KEGG" id="sbr:SY1_10590"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.267"/>
    <dbReference type="HOGENOM" id="CLU_028723_5_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-674-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="8">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="182" mass="21345" checksum="3325C2E2F01239C8" modified="2010-05-18" version="1">MELAAEAAKPWWRETIETIVWAFVLAMIIRTFVVQAFWIPSGSMIPTLEIGDRVLVAKFWNWFFEPSRGSIYVFTYPKDRDRDFVKRIIGLPGDTVDIRDGVVFVNGRPTEEPYVVNHDAYSIRPGEFFQRPFTVPQDSYFVMGDNRPNSQDSRFWGFVRRSDLHGPAFFRYWPLTRLGIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T1</accession>
    <name>D4M8T1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SY1_10780</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.285"/>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-682-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBL28276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="680" mass="75901" checksum="49E034696548723C" modified="2010-05-18" version="1">MRLFIAEKPSLARAIAAVLPQPQRASRLYIEAGNDVVAWAAGHLLEQAMPEQYDEKYKRWNLADLPIIPEEWKMLVKKESRDLFDNLKTLLKKADSVVNAGDCDREGQLLIDEILEHCKYKGPVQRILISDTNPDAVKKALAELKPNEDFRGDRDAARARSQADWLHGMNMTRLYTKLAEKNGYDGGPLRIGRVKTPVTALVVRRDLEIESFVPKPYWTLQAQIQVKEGAFWAGWRPKEEQTGLDEEGRLVDKATGEELASRLKGKPAVITKYESKKQSVKPPLGYSLPKLQMAASRKHDLSPSRVLEVCQKLYEQGVLTYPRSDCEYLPEGHQDEAEKVLAVIDALSSLKRPDELNTARKTPVFNGKKVEEHHAIIPSASCRASKPLEGDEPLIFELVARRYLVFFMPDHEYMQTSITAEVEGETFVASGRRVLAEGWKAVERNDEPEKNDDKEDREEEQAALPVVSEGEKGECRDTKLQEKQTKAPARFTEASLLRAMNEVHKFVADPKVKKILRETDGIGTAATQAGILKDLITFGQLQKQKKQLISTPAARSLIQALPEAITLPDLTALWETKFRAIKEGTLSIEDMMEQMATTIRESIAQAGSVSVQGSGEKKPVKATKKTAPKAGKGDVKCPKCGAKMVLRNGKNGPFWGCGNYPTCRATADDDGGKPVFKKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T2</accession>
    <name>D4M8T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10790"/>
    <dbReference type="HOGENOM" id="CLU_1011041_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-683-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="275" mass="31081" checksum="34D76A93DB2713E1" modified="2010-05-18" version="1">MGELNKLYQAISNFSEAKERLDRTPRKKFTIAALQNTTTTLRDVAGFGNVSDMLDAEQLCINLEKALYANTPDDEARYDKQIVENMAIRGSLDDILDVKGYQAHFERLKVLGVNPDNLPKGEPFETNCNRQIKYLGSAKNGFSEPEEKDFFAARQENLRAVILICRERQREALMPEAVSSELAGMITEDTGVQEPTINLHPYTKGQWFTGKIIHTDAAHGRCIQQTASRLFTVHRLEKLETVPEQGQDLKITYSKDGAKAKLDPIVQKQSRSLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V8</accession>
    <name>D4M8V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_11180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11180"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.327"/>
    <dbReference type="HOGENOM" id="CLU_041674_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-709-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="363" mass="40764" checksum="AFDC152A732B1A6C" modified="2010-05-18" version="1">MAPVIRVLRENGNFDVTVLATGQHTDMLVQALSHFCIKADVNLNIMRRRQSLDHITSSVLTGVGSFLDGAPQDMILVHGDTSTTLAAALAAFYRHIPIGHVEAGLRSHNMALPFPEEANRVLTDRLASLYFTPTESDAENLRREGVDPRRIHVTGNTVIDALFWTLENLAQPEVLRELPPETPLVLMTAHRRESWGEPLMRICSAVSELIQQRPYVRVLVPLHKNPEVRDRIQERLGMYPQMLFTEPLSYPDFVSAMNRSLFILTDSGGIQEEATALRKPVLIMRTLSERPEAVTLGTGVLVGTERETILRESLRLLDDAAYRRSFSDRGMPFGDGTASPRIRDVIGRFFNSGTDEDWEIDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W0</accession>
    <name>D4M8W0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_11220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11220"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.330"/>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-711-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="38"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="207" mass="23238" checksum="A2608B653B337B3C" modified="2010-05-18" version="1">MDDKERDAAWEAAWEDLRGRVAACRRCGLCEARTNTVFGQGAVRTPIVMVGEGPGADEDAQGLAFVGRAGQLLTKILSAAGIDRESVFITNVVKCRPPNNRTPTQEEMLKCADFLEAQLLLLRPRILVCLGNTPLKWLLRTSEGITALRGRWFDWRGVQLFPMFHPSYLLRNDSRQKGSPKDLTWQDVQNLKARLDEITKRKGTEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z1</accession>
    <name>D4M8Z1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_11740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11740"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.409"/>
    <dbReference type="HOGENOM" id="CLU_038944_8_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-744-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="252" mass="27180" checksum="13E599A5933E1FB1" modified="2010-05-18" version="1">MSETKNVQDAACKPGQLGGAGRRYAGKAVLLILLAAAIGAYFVWPPYRGVIDSIFSAFATGDFAAVRRFVERYGTMAAAVSFLLMVFQSIVAPLPAFLITFANANLFGWWRGAILSWASAMAGAAACFYIARILGRDVVEKLSSKTGLRSIDAFFERHGAQSILIARLLPFISFDIVSYAAGLTSMGFWPFFIATGVGQLPATIVYSYVGGMLTGGAKLFVTGLLILFALSILIVLLKQVYTERKKRSDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z5</accession>
    <name>D4M8Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chlamydia polymorphic membrane protein (Chlamydia_PMP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11780"/>
    <dbReference type="HOGENOM" id="CLU_347423_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-748-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003368">
        <property type="entry name" value="POMP_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030821">
        <property type="entry name" value="Synergist_CTERM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02415">
        <property type="entry name" value="Chlam_PMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04564">
        <property type="entry name" value="Synergist_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="812" mass="83978" checksum="3265AF93AC2AECC7" modified="2010-05-18" version="1">MLALCFAFVSPADARVYRVNGSAIASGDGGSWSTPLNEAGFAAALSGAVSGDEFWIAKGVYRPAIPVSTDAVTTAEQGKSFTLKEGISLYGGFAGDETEREQRKPDNNVVVLTGDLGLDDGRDAWGVTLSADVIRGKNSKNVLKGTNVKGVRLDGVAVSGGDQGVGAGLSLGRSDIVIQNCLFQGNRAVSFGGGINAAAASLDVCSSRFLGNRGGPNSHGGAVNSVQSYLKLVDCRFEGNATGADKPGNKAGNGGAVQFSDKKGGDKTLTVERCRFSNNTAGAGGGGLYVQNAGTDVTVRGTVFEGNRATHNGGAARFSTSTNILVEDCLFTGNSTVIEGGAIYNSEVGSGDRGMTIRSCTFSGNKTYDDAHVADPNKGSGGAVYNGVSSPVLVNCTFTDNEAKYGGALFNRTGSYPLLLNCTFFGNKAIPQGGQGGEGSSVYNTKCKTGACKPGGGRIVAFNSIFWDGGAEEIVSENDDDSGAALHRSIVRGGAVRGGEVVLSEVTSDDPRLSSPGNHGGSVPTCLPAWNSSARDRGWRVGALTSADVLSADVFWRDWAECAIPAVDARGVARPQFGGVDIGAVELTSTPQPQPEPGPSPVPQPGPDPKPEPQPQPQPQPNPDPAPKPVPKPIPEKPITEAPAEAPMDARYDDSGAWTLAVGEVGSDGTAEVVVSVRLKPVPRRLTLLDVETRNFVEASTAVFLDGEPVTFSAAVSDTGMTRLYEYELRIRGRVRGEALNGAVGQRAALAAMTYMLEGDEVPTRLAFSGDGVSLNGMKRETSRSGGGCDAGLSALALMALLPVVGRRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M932</accession>
    <name>D4M932_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12230"/>
    <dbReference type="HOGENOM" id="CLU_1584067_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-785-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061205" evidence="1">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="168" mass="17793" checksum="D21730CF0BE6DABE" modified="2010-05-18" version="1">MKTMKVRALCAAFFLAFLALPAPSAEAANWLDNADISWYEDVVSANPQATEFEISTPEEFAGLVELTQRGNAFEGKTVSLKSDLDLNGAEWTPVGTFSGVFDGKGHVVKGRTTLFSHISGEGALLRGLRKVGDSSGSGLVKVLSKGTVEDCFFKGAVLTDPTPPLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M946</accession>
    <name>D4M946_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein ChrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_12550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12550"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.490"/>
    <dbReference type="HOGENOM" id="CLU_018106_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-799-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="184" mass="19357" checksum="64C8DF90F615FC77" modified="2010-05-18" version="1">MFKRLWSIYVRFFRIGAFTIGGGIVMLGVIEAEVRATGEFTDEEIADMIVLATAVPGPIATNLSFVAGRAMGGLPAAVTAVLGTATAPFLSILFLSSLIIEHLKNPWMISFFLGATAGVVVVVWNSLWKMIRSSVLKGVPQALAFATTVGLLFVWDVNPFIALAAGGLVSILGGRFLPGGGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M953</accession>
    <name>D4M953_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 2, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_12690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12690"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.502"/>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-806-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="358" mass="38035" checksum="80090B13AB9290AB" modified="2010-05-18" version="1">MTIKRFVNLKRAEARRIFATYAVVTAAYGFMQILSATGLLSSTMRGMLVPVCAYMVMAIALNLVVGILGELSLGHAGFMSVGAFTGVASAIMLQNLIPFAPARLAVAMLVGSGFAAAAGFLIGIPVLRLKGDYLAIVTLAFGEIIKSVFNNFYLGMDSGGISFSMLSDKTRLLPGGRLIIAGPMGIGGIQKISTFTVGFILVMIALAVMYNLMNSRAGRAFMAIRDVCIAAESVGINITRYKMMAFVTSAALAGAAGALFAMNYSTIVANKFDFNTSILVLVFVVLGGQGNILGSIVAAAALTILPEKLRQFADYRMLLYAVVLIAVMLATNNAAVKGFLTRFNPFLRRAREEDEHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M978</accession>
    <name>D4M978_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ORF">SY1_13150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13150"/>
    <dbReference type="HOGENOM" id="CLU_129084_1_3_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="66" mass="7276" checksum="6DAF069878DA1D58" modified="2010-05-18" version="1">MATPKRKTSHSRTAQRKAQWLGALSAPEFQSCPRCGEKVQAYRACAACGYYRGRKVLTVGEEEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M982</accession>
    <name>D4M982_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_13200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13200"/>
    <dbReference type="HOGENOM" id="CLU_031275_8_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-837-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="423" mass="46048" checksum="375C5D9578E084CC" modified="2010-05-18" version="1">MKWHNTKFMLRHMKIIVGLMTILTAVALGFVLHLASGVFIPLVIAWFLLQIFRPVLKLGDQLKLPPFLKIALVFVLLFCMTLIGVRFVASQAVEFGEVYQRFYPDLEPTIEKFTNTLMTLGFLPNSRPSVRSEEQEEEDVPRNTFILTAAASADSAPPALSGGSILMGELTKKLRTDWTSYVRYISEMAITLLSKLVLSLVFLMFMLLEAPYVVDKIDEAFRGPSARTGETVKSILATISSQISSYLGALTLISVATGLCAWVILTSCNVELATGWAVLTILLNFIPTVGSIIATVPPVVMAILQSPTSLTMPLLVLVLLTAVQVSIGNILTPKIMGDRLGLSPVIILLSLLLWGVIWGIPGAILSTPIASILQIICASTHSLKPIAILMGSGENARKARMKSDREAEAARQQRGEKGQGENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M991</accession>
    <name>D4M991_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13360"/>
    <dbReference type="HOGENOM" id="CLU_1466185_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-847-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="184" mass="20065" checksum="F54A6EB8A47F4860" modified="2010-05-18" version="1">MLSSDFLMDLARRIQEGVKLTEQELLRRASAPGGEGDAAGFSPNEAISGRSADRDLAGNFAAAIAKLLDEGDVSEVELAEKLGCLAEDVHALRRRSPSLPSRELLSVLALKLALTPEQAKDLFLAAGYEFSKCEVSDIVLLYCLEQGVFDIDEVNDALTCFNLKRLSPQAAVVELDRRAWVTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M998</accession>
    <name>D4M998_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_13490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13490"/>
    <dbReference type="HOGENOM" id="CLU_081811_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-854-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="210" mass="22044" checksum="CA19119AD1F8F87D" modified="2010-05-18" version="1">MHDLVVYGAGGLGREVGEMVRRINERHRFWRLLGFVDDGGASGDLGGSEFLGGLEFIKGFNGPLDVAIAIANPAAKRRLYETLKRDCPNVTFPSVIDTEARLSSRVSLDEGVIISHFCSVSVEVRLGRCVFLNTGTHVGHDTTIGDFSSVMPNVDISGNVTVGSDALIGVNSAILQGVAVGSGATVGMGAIVMTPVPEGCTVLGNPARKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A2</accession>
    <name>D4M9A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenases of various substrate specificities</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13560"/>
    <dbReference type="HOGENOM" id="CLU_2861266_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-858-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="64" mass="6523" checksum="64975096B47175E5" modified="2010-05-18" version="1">MTDPFALEGHLILVTGASSGIGRCVAIRAAQRGAKLILTGRDEARLAETASQPTARGTGGSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B1</accession>
    <name>D4M9B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinylglutamate desuccinylase / Aspartoacylase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.600"/>
    <dbReference type="HOGENOM" id="CLU_060714_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-867-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="329" mass="36872" checksum="F7D0D09AF65AB6C4" modified="2010-05-18" version="1">MDTPVYLFDSGVPGGSMLYLGGTHPYEPATSLSAYLIMENLSVEKGRVFVCPHANRSASTVGMLGNAYPKFLHVETPFGPKAYRIGDRNSSPLDQWPDPFTYVHYPSGQNLDYTDSRNLNRTFPGRPDGNLTEQLAFAFMELTRKENITLFVDSHEASLMYPVVATYVAHDRAQDMAMMAAMELTDSEFPMKCEASPKSLRGLTHREVGDFSDALVILMETPEPFIDRVAGKITEDLMMTGKDEFLQTAAEHELLFCAYDISVGCPMWDRVGRHLSGTLAMIRQMNDFAADPEKELRLSFPTYTDVKEKGLGAFYHDPSRADPSKVFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B3</accession>
    <name>D4M9B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13710"/>
    <dbReference type="HOGENOM" id="CLU_323322_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-869-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="894" mass="100485" checksum="F8021784233025DC" modified="2010-05-18" version="1">MPEVPLCLSSEQVDRIREYCSKWVEARTVVRRRMDAYEEDYAAFEKEKAEKGNPTLLDDDPAGRTWFEKIRDELNGEFQLDNSCALIADGPDKARYWAPKDIAAVMNLHVTTITRRLKAIGKAPSADWRGRLKACTHKTERPPVYSDGIFDVLMDWKAEYYLKSTILGPHHYKGEKISPEDEHRIRSFWQETMDEARREYDDRKAGEPEVSPEQEEELLRFVMDLSDEDRSVWSVRFPWDRPSHRGDVPDEGEPRGAALGGFKDAFTELWRSMSHWKGNLSAAALLTIYSELSYILSSLYAWFPLIALLVLTACFLCLRYRVPPRPFWGAAGSTAILFLGLWVLCFVGRGFSAENPSPLMRIPLMKDLQQGIARLEGIEARRTAETQAMLEEALQVTHAFLRERRRTDTPVSEAEYQQMLHKTEARETPESLRPLRSELRVNEARIYLHWAFDDYRSGLTKLQAAEQLLLQTREELTLAGRGHDVLQGRTALALSEVLYAGMERGLWGERADEAIRAADMASSLLRDREPQEAIAAQEARSHLFYFRGGQSIDPNSADLRQAEEAAREGLALSARNEGFLYPELALALGLALSAQENARKAIQAFTDGLRHTDMQLQPNLYVALSAALADANAVLCLGTKDPASRRDAEMALSAAFGVMNRYAHLTSDAFLHFALARASLAAGLAAQNGEDLEQALSSVNRVLDVWTFTPYTSNHIQAACTKAAILTGMTFLPKKHEDFDRLERAGSEMGSEAGDMIRNAARDARRARILMDQAVNREALRKAIQTLEQIAYYDRTNPTLARKCATDLFNAYLVLVEAHAAAGAMDKLFGPEDDEDHLAAAERALHRARELAGGQGTKKIERAESSLKRLRLSSSAAQMLMRLSGKTSQDLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B4</accession>
    <name>D4M9B4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">SY1_13720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="KEGG" id="sbr:SY1_13720"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.604"/>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="184" mass="19657" checksum="BBBC2CFA67B04D48" modified="2010-05-18" version="1">MITGRKGEGRDVYSCLFEDRIVFLGSPIDDAVANGIVAQLLLLANRDEKKEISLYINSPGGSVSAGLAIYDTMQFVPCPVATTCIGQAASMGAVLLAAGAKGRRSALPHAKVMLHQPLGGAGGQASDVALFAQELIKTREVLNALIAHHTAQKVETVEKDTDRDFFMSAQEAQRYGIIDEVIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C4</accession>
    <name>D4M9C4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="7" type="ORF">SY1_13880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13880"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.625"/>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="357" mass="40415" checksum="DE258F027D37B5E2" modified="2010-05-18" version="1">MNIEPKLQAIEKEFLDIEERMGDPATASDPRALQDLGKKRAQLEPVVEKYRAYRAAVASIAEARDLLKGGDPEIAELAREELSELEPQIENFEKELTILLLPKDPNDEKSVIVEIRAGVGGDEAALFAADLYRMYTRFCERQRWKIEVIDSSLIGLGGYKEVIFRIDSHGAYSMMKYESGGHRVQRVPVTEASGRIHTSSATVAVMPEVEDIEIEIRPEDLKVDTYRSSGAGGQHVNMTDSAVRITHLPTGIVATCQDERSQIKNRARAMAYLKARLYALEQEKQNAEQASERRGMIGSGDRSERIRTYNFPQNRITDHRINLTLYKLDNYLDGDLFEMIDAMILAEQTQKLEHLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E8</accession>
    <name>D4M9E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_14550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14550"/>
    <dbReference type="HOGENOM" id="CLU_1097344_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-904-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="253" mass="29370" checksum="A82B6D55E078BA95" modified="2010-05-18" version="1">MSLLLGGLWRLMEYRAWMPLSGYRVDAQDPALEERLWSVFPSRCFRFWPYFLKDAEGLKQFLERDMPVSVVTTMPRFGRFATAIKRLTPWLKVRWYDQLWCVSREGRMWNVAEAQGHMTSADMGSGPTWHLPQLKEDGDRAPSGVFDFPMPLDALAGFLDEYQRYGWFRAVQDIAWDRRAGADLFRLKLRRNKQLFELLIQPEKYEGQDLGVGLEELFSKLSKEGGNHLIDATYRGKILLRDLPGGPEEGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H9</accession>
    <name>D4M9H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15010"/>
    <dbReference type="HOGENOM" id="CLU_042512_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-936-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="152"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="240" mass="27231" checksum="C2FE167D5F181BF9" modified="2010-05-18" version="1">MAFELRGDGKERPEPEERKLRFDVNAVEEALDAASREWGLPRELLRAEVVGSERGFLGLFGSRLKVEVTPTGDLLGLKGAAFLNEVMERMDLDAQASLTEDGTIDIEGPDAMDCVVGRYGDALKAMEYLLNLALRDPASEPRVRVDSCGYRERRTRSLERLAEATARQVAEYGRPVRLDPMLSWERWVIHTTLQDNQDVRTESVGEPPMRKVVVLPRFDASESMGRRYASRPRPPRRRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L1</accession>
    <name>D4M9L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15530"/>
    <dbReference type="HOGENOM" id="CLU_2232634_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-968-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014127">
        <property type="entry name" value="CHP02757"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09674">
        <property type="entry name" value="DUF2400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="105" mass="11857" checksum="2A4D1BD21A6CF8D6" modified="2010-05-18" version="1">MSNTEGRDRRLRAFLDGLYFAYSRRELISPDPLEFLKPYDLPDREVVALVASSLAYGRVAQILRSVRRVLNALGPHPASSSWNVPSAFRRPSPASSTGSPRRRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L3</accession>
    <name>D4M9L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon dioxide concentrating mechanism/carboxysome shell protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.815"/>
    <dbReference type="HOGENOM" id="CLU_064903_5_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-970-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="93" mass="9494" checksum="57178EA8E0401808" modified="2010-05-18" version="1">MNGEALGMIETRGLVGAIEAADAMVKAANVHLIGYEKIGSAYVTVMVRGDVGAVKAAVDAGAAAAKRVGEVVSVHVIPRPHSDTEKLLPKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L7</accession>
    <name>D4M9L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP:cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_15710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.841"/>
    <dbReference type="HOGENOM" id="CLU_068893_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-974-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="4">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="34998" checksum="34C00BEEA303625F" modified="2010-05-18" version="1">MSARIYTGGGDRGETRLWDGQRVSKRDPRIELNGTLDEAGALIGLARGLGPAAMQDDLLRVQRLLQDLMAYVARGRREAKVPAASSLEAWIDELLEGYPMRPEFVLPGDSPAGGALHAARAVARRAERVALPLWDGGGVIEEEAYRLINRLSDLLYVLAHKADVETQVARIVRTISEGEAGPSRGPEAPAQEVTLDEALEVIECARTAAEAIGLPVVVAVCSPDAVPVAFQRMKDSLPVSVRLAASKAATALKMKMDTDRLAPLVQPGAPLYGLNNDPDIVAFGGGRLLMDKGVIVGAVGVSGGTVEQDTGVADAAVRCFEGLRRAGAQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N0</accession>
    <name>D4M9N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein, P2 protein I family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15880"/>
    <dbReference type="HOGENOM" id="CLU_086293_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-987-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006521">
        <property type="entry name" value="Tail_protein_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09684">
        <property type="entry name" value="Tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01634">
        <property type="entry name" value="tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="230" mass="25853" checksum="B8530B7AAC358351" modified="2010-05-18" version="1">MSRNLDLLPSNALPSERALSLAARFSDDILPEDIKKLWRPQEAPAAFLPFLAWGLHVDFWRDELASQAKRNLIAGAFEWHRLEGTFGAIRRICTAVFGETRVLPWYEYSGEPYGFRVTTEGRMGTIEDWESLRKAIWFAQALRDWLDGIEIHRNLRLDLSHGTATFRSGLHEIRPEYPELNETRLTVGIATVQGGYASVGLSRPKGTRTAVFSGIAMVQVHYVTIGPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N7</accession>
    <name>D4M9N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15960"/>
    <dbReference type="HOGENOM" id="CLU_1924508_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-994-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="131" mass="14133" checksum="701BF8E56CF77C65" modified="2010-05-18" version="1">MPEIEIDVAYLRRLGNLPGPVQLGNSVLEPHVESAVSEVLAILGARVPQGAVEEGRVRLAMGCFAMANALPVLNTFYLSQAEKVPRQVALTDYVFHDAGELLKLAAYWKNRGYEALRDVGRTGGTVGVSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S6</accession>
    <name>D4M9S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_16510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.921"/>
    <dbReference type="HOGENOM" id="CLU_090277_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1033-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="203" mass="22951" checksum="8031299C88E14132" modified="2010-05-18" version="1">MDIETCIKKLGYVGVLDFATVDESGAPQVRNVSAIHYEGTSLYFLTARGKYFASQLKNDGRVQILSYTKYKEMIRLSGRAEEVPEEAQVKWRNVLYQEQPYLENVYPGETKNIDTIFLLKDYTIEYFCLSTRPITREYFVVGNAESLKKGYHIMENCIGCGTCQAVCPQDAISSGTPFAIDESHCLQCGNCAENCPVKAIERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T4</accession>
    <name>D4M9T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16710"/>
    <dbReference type="HOGENOM" id="CLU_773291_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1041-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="358" mass="40083" checksum="FF6A305885B0EA0A" modified="2010-05-18" version="1">MRIRSVWRAGAVLLVLLTLVLSPARRGAAAPEPRTVSVVIFPTLNTTGLEVWESKYYPYNVLERRMSEYLETLYKRSPLIEARILDESGVNQWLAGPRRGDDMAVQMELCEAVLKERRAVGNVETGRVQLRLRVYDSAHVKQVAVRSTEGADRRFTLDSPEGAFWLDAAAVSLFVPFKNGLDLFGLTGGQDRGQRMSRPTWDQFRSTSHWQAVKNAIDEAYRQSLAQMMNVIHSNEPQSASMANDTFSPAFSTVGRILAPTARSTRRRREYIISLGGMAQGSQDSVRVGEVLDVVRSDTYVTVDPEHPVAVLPEVIGKVKVIRVYDLNAVVRVIKDNKKEPIALKDMVIKRTGVSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T7</accession>
    <name>D4M9T7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T3SS_YcgR_PilZN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16780"/>
    <dbReference type="HOGENOM" id="CLU_1248467_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1044-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009926">
        <property type="entry name" value="T3SS_YcgR_PilZN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12945">
        <property type="entry name" value="YcgR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T3SS_YcgR_PilZN" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="249" mass="27470" checksum="AF125D799BE6367F" modified="2010-05-18" version="1">MTMATEQDHDKNLKLINSLIGAKAELTFSTGLYKGKYASRLEDVKSAKEDEGPLLGMAHPMFKGALLPVARSLELSLRLEGNACFYQSPAEIVRTVVNVPIPLVWLRLDAPLERVQRRMFVRVPCGIKARAYLLEVNSEYEAAEAERRGAPLPTPPQAWFPLLLNDISLGGVGALIQKEQADMCRLKARYLLQMAVSGTEFFVICDVVTAQKDEAGRLSAGLSYEGLPAFTEKLMGAFIRQQELNGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U6</accession>
    <name>D4M9U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17070"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.971"/>
    <dbReference type="HOGENOM" id="CLU_082726_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1052-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="248" mass="28106" checksum="05D88DC7E540036E" modified="2010-05-18" version="1">MQHRAFEKMLETQDTHWWFKGKRRILNKIIEKRVFTGEPCDILEIGCGTGSNLPMLARFGNVVGLELDDYARKVIPPLPGVSIAKGWLPDGLEAVRGRQFDLVCLFDVLEHIEHDGEALSVLKKLIRPDGKLLLTVPAYQWMFGPHDRDLGHYRRYTRPKLRALCVQQGYTVSYTGYINSLLFPFMAVSRIAGRLMGGARTVQLETSVPPFKLNELLYTIFSAESFWIPNISLPFGGSVVLLCEGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V5</accession>
    <name>D4M9V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase/alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_17220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17220"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.989"/>
    <dbReference type="HOGENOM" id="CLU_018719_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1062-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021923">
        <property type="entry name" value="DUF3536"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12055">
        <property type="entry name" value="DUF3536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="112"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="804" mass="91271" checksum="99B4ACA558388F27" modified="2010-05-18" version="1">MPRYVCIHGHFYQPPRENPWLETVELQESAAPWHDWNARIAAECYSRNAASRILNGSGKIVKICNNYSRMSFNLGPTLLSWLQENDPLCYDAILEADAIGARRFSGHGPAVAQVYNHVIMPLANRRDKETQVLWGIADFEKRFRRRPEGMWLAEAAVDTETLEVLAEHGILFTVLSPYQADSVRPCGGGVWQDAKGGRIDTTRPYRCSLPSGRSIALFFYDGLLSQKIAFGGMLDNGEHFARQLIDAHPDRGFPLLSHVATDGESYGHHHDHGDMALAYCLETVDRSRDATLTVYGEYLAFYPPDWEVRIIENSSWSCAHGVERWRSDCGCSTGTPGFHQRWRAPLRRAMDMLRDELIAPFEREAGKLLKDPWEARNRYIDLILDRTPECVEAWLKQNASRSLTDEERVRAISLLEMQRAALLMFTSCGWFFDEVSRIEPVQVMRYAAHAMELADRFLGRDLEPAFLDILSGAPSNVPELKNGAKVYELLVKQGRVDMPQLAAYYGITSLLQGFRQSFREGCWNLAGSTLILRDGSEDASAFSAGTVRVTSRITGESGAFLFAANHRGGISLLCGVTPEKEMRPISTQEAQELRRLFAPAMERAMVDRFGYTLYSLRHIPADAQRRLLDELLKQDVQRIEAVVRSIVQNYDQLLEYMATLEVRPPEIIASAAKIVMSASLLDLLRQDLPDFEALNRILSLSVQRQIALRSDRLCFAVSEWLKTRMMRLCGNPLDLQQVRAATDLVRTFQEGFQWRLSLYDAQNLYHEMLRRWRGELSAAPADLREAIFALGRQLQFSEEFLKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y3</accession>
    <name>D4M9Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_17710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1040"/>
    <dbReference type="HOGENOM" id="CLU_010123_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1091-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="764" mass="87044" checksum="B617D733224DCA64" modified="2010-05-18" version="1">MSRDVPREAWRTLLRGSLNGDLKSHPEKRLIDHLLGTAELARQIVEFHGLEDIAFDVEAAALTHDPGKADPEFQKYLLGKGKGVNHSLPSSFFTFSLQQDNADPFDAFFSVEAVRRHHSKIEDWRTSSSFWANYRASQKKIGEDMRALIPQWPCPLNELCWKKFIYAIDDRYPEDYPFPDYWLRLRSVLSVLVAGDRLDAINVKTMNLQPLPNFKPYPFSSVAGVSERRRATDAWRSDVAECCLRNVAEIRSPGLFTLTLPTGAGKTNIGLRIAHTLAKNLGYSTIVYALPFISIVEQNAKFAKDVFGAESVQEDHSLMLAALDDEDEKGEYDKPGEWKRAQRLFRYWGSPVVVTTMVQLWNTIFNSKAGATIDFHRLRNAVVLMDEPQGIDCHLWPELGKVLTFIHERWGTVFILMTATQPKIFEGTELAPRVCFPFNRHRYHFLKEKHGLKDLPGLLKEHVPAFAERSGMLVFNTRSSARAAYDLLRPILGDAPVFMLSRWMTPKHRRETLEEIKSLEVSGKRHYLIATQVVEAGVDLDFEWAFRDLAPLDSLVQVAGRCNRSGERSDGFVLITSLLSEKGRPFSARVYDDVPMDLTQLLLEEFPGFDEQDVQDIVARYYEKISNAIEPKPLWRDIEEGNWGDYTPLFKEMDFDVPVYVDHDGDLDDLLNELMTLDRTLDNRERLKTLNNRLQQYAIGVRKDLLKEWLDRVGNFVGGSSQNPLEQYGDYCVIRCSGIGEGPDSPYHPEVGFSPCSQGAGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z0</accession>
    <name>D4M9Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Fe3+-siderophore transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_17840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17840"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1053"/>
    <dbReference type="HOGENOM" id="CLU_013016_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1098-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="354" mass="37484" checksum="DF350DC0CB4C71BD" modified="2010-05-18" version="1">MSPLSPFRRTGVPALVLLALLLLTMTFGVSTGPVPIPFGRVWGIVLHQVFPDWQAMAQDWPQNEVSIVWQLRLPRVLLGAIVGAGLMMAGAAIQSLVRNSLADPYLLGISSGGCAGAVAALLLLGKVLGSSYTGLSTVFLMAFLGSLLAFGLVLLIAAQGEGLTPMRMILSGLAVSYMFTALTNFMVYLNQRSGAESAMFWMLGGLGGARWDRLPIPLAVTAACLVLLVLQGRSLNALMLGDESAAALGVDVRRFRRFLFALTSLLTGTLVAVSGSIGFVGLVVPHVMRMTVGADHRRILPLGALVGAIFLILADAFSRAVLAPRELPLGVVTGFVGAPFFIWLLRRSGRQGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA00</accession>
    <name>D4MA00_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplM</name>
        <name evidence="5" type="ORF">SY1_18080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1072"/>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="143" mass="15896" checksum="A73F824451BC90C1" modified="2010-05-18" version="1">MAGSSSYLVKPGQVERKWYVIDAADRPVGRLASAIARILTGKNKPTYTPHVDTGDYVVVINAEKVKMTGKKATQSKWHYHTGHPGGYRAIPWARLVVEKPEFLLEHVVRGMLPRNRLKYASKLKVYAGPSHPHAAQAPETLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA04</accession>
    <name>D4MA04_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SY1_18380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1100"/>
    <dbReference type="HOGENOM" id="CLU_031922_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1112-MON"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBL28699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="357" mass="39250" checksum="0843DB8A5E97B034" modified="2010-05-18" version="1">MRIAFTRNERPGKLPPTKELGWGTVFTDHMFLMDYGDAEGWHGPRIVPFGPIVLSPAASVLHYGAEVFEGLKAYRRADGVVQLFRPMENALRLNLSCERIGLPRLNPEDTVEAIREIVRTDQSWVPSDPGTSLYIRPFVFATDPALALHGIHRATFAIILSPVGSYFPDGLKPVRIMIETEDVRAVRGGTGYTKCGGNYAASNRAGDRAMEKGYAQVLWLDGVERRYVEEVGAMNVMFKIGERVVTPSLADGSILPGITRKSCIEMMRSWGMAVEERKVGVDELTRAAEDGTLEEAWGTGTAAVISPIGELSYGGKSYVVNGTEIGPTSRRLYDELTGLQWGSRPDPFGWTVPIPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA32</accession>
    <name>D4MA32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_18780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1143"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1140-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="51"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="335"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="580" mass="63827" checksum="2A5F19F88087A388" modified="2010-05-18" version="1">MKDSLFRTVTIGHPEKLRKSVFYTIVSYLVNVVPFGISIEVARTVFTAWSAGGAPDMAKLWGLSAFLLVWMLVMFAAEVPAYRACYWDAYEASAQGRAELAEKLRRLPLGYFARRDPGDLVNMIMGDFLLLETAISHQVPQMVGGLVLPAIAFVGLCFWNPLMAVAMFVSLPAAALVLALSTRLQNRLSQKHMRAKIDAGNRIQEYMNGIRVIKAYNLTGGRFARLESAFRSFMKESIRIEAAMGPFAMLAISMIRLGLTLMIVLGVHLMIGGTLDPVTFVGFLIVGTRVYDPLTAALLNFFVFRYSTLAGRRILSLMEEPEMTGGGDAPDRHDIELKNVTFGYGDEPVLRDVSLTFPQGRLTALVGPSGCGKTTLMKVMARFYDPQSGTVLFGGADEHGLDPEKLMRRISFVFQDVYLFRDTVRNNIAFGREGATEAEVEEAAKRACAHDFILRLPQGYDTMVGEGGSTLSGGEKQRISIARALLKDAPVVLLDEATASLDPENEVEVQRAVNALVEGRTVVVIAHKLRTVENADNIVVMEAGRVVDQGRHAELLERGGLYARLWTLQNESVGWSLTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA80</accession>
    <name>D4MA80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted acyl-CoA transferases/carnitine dehydratase</fullName>
            <ecNumber evidence="1">2.8.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_19430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.3.16" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19430"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1207"/>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1189-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033608">
        <property type="term" value="F:formyl-CoA transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="406" mass="44499" checksum="DBB16976D155CA28" modified="2010-05-18" version="1">MDDNRSMHELLSKRPLEGVRIMDMTHAYSGPFCTMHLADHGAEVIKLEVPGKGDQSRTWEPIKDGASGYFSCYNRNKYGLALDLKSDEGKRIYKELIAKVDVVVENFRVGTMEKLGLGYDVLKEINPRLIYASISGFGIEGPDAPRPCYDIVAQALGGIIGVTGFGDDIVKVGPAIADNYSGTYLALGIVIALFQRERTGLGRRLDVSMVDSIFSILEVGPLAYTIKGEISRAIGNRDPGITPFDAFRASDGMFVIACGTDRFFAALCSVMNMPDLPRDPRFATNSLRCTHEAELKEIIESWSLKHNVADIERQILAAGIPFGNILTPAQACESDIIRRRNMLWKVYDPAFGKEIEIIGSPIKMHGCADAPRKAAPGIGEDTDSILKELINMSDGEIAKLHENGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA81</accession>
    <name>D4MA81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_19440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19440"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1208"/>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1190-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="428" mass="44106" checksum="83B4464021245413" modified="2010-05-18" version="1">MASRISMQDVQTRNAALSRKRWSILAASCLANLCVGSVYSWSVFAGPMARHLNALNGTSLTAADLAIVFSLANGDAFITMILGGILDRTLGARLMILIGVTVFGLGFIVSSMATNTLTLALGYGILCGLAEGFTYVCTISNTVKFFPDKKGLAGGISTASYGLSSILIPPVADALTHAVGVNRAFLIFGAVIIGLAFVSSLSIVNCPDDFVPDGWTPQAGMGAAGAGDKSTLQMLSSSVFYVMLAMLFVGSTLGLMAISEAASIAQTMIGMTSAAAALVVSVLALFNTAGRIAAGWISDRIGRVKTLMAVYILAAAASLTTYVSGGNKSVALFCGGICLVGLCYGAFMGVYPGFTSDQFGVKHSSLNYGVMFVGFSSAGFAGPMTMRAVFNGQGSYRPAFLMAAGLAVSGLAISFLYRAIAKKDELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH8</accession>
    <name>D4MAH8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ORF">SY1_21280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1388"/>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1287-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="160"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="553"/>
            <end position="556"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="608" mass="68202" checksum="7E249051C80F3C1F" modified="2010-05-18" version="1">MASSSGSETARGDFFDRSWQRTKLCGDFSREDAGREVRANGWVRRRRDLGGIIFIELWDHTGSVQVVFNPEAGDVHGAAGGLRSEYCVAVRGKLRIRPEGTENPGLKTGAVEIVAQDLLILSKASPIPFEVGEATDDVDENLRLTYRYLDLRRERMQNNLRTRSRINAFTRRYLEGQGFVELETPILTKATPEGARDYLVPSRVTPGTFYALPQSPQLFKQILMVSGFDRYYQIARCFRDEDLRADRQPEFTQVDIEMSYVVEDDVMELIEGYMKGLFKEVLGVDVPTPFGRMLYWDAMDRYGSDKPDLRVTLELCDVASVFAKASFEPFKQVLDGGGVVRALPLPGGAALSRKELMDLEDRARKFGASGLAAFQMKEGALKGPLVKFLTEGELEELCRIANLKDGDALFVLADASRARACTILGVLRLDLGRSRGFMNEKEWRFLWVTKFPLFEWSDEEKRWVAMHHPFTSPVLEEGDLMERDPSKALARAYDCVLNGNEVGGGSIRIHDPEVQARLFKCLGISPEEAKRRFGFFLNALSYGTPPHGGIALGVDRLVMLLCGGQSIRDVMTFPKTQRAQCLLSQAPDVVEQSRLDELRIAVVPPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI1</accession>
    <name>D4MAI1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">SY1_21370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1397"/>
    <dbReference type="HOGENOM" id="CLU_092403_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="198" mass="22801" checksum="1845F6BA63584541" modified="2010-05-18" version="1">MATRREPRFKLSRHLGVNVCGHPKAMKRVDTKKPARGGQKVSQYALQLMEKQKIKAYYGILERQFARYFKIAKKSTEMTGVALLKNLECRLDNLVYRIGFARSIRQARQMVSHGHILLNGVKVDIPSCNVKVNDVISLKEKSRTNETFQNNFQGLASFSVPYLEKDKNQFSAKLIREPMREELPIEVNEILAVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI9</accession>
    <name>D4MAI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_21600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21600"/>
    <dbReference type="HOGENOM" id="CLU_2105405_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1298-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="115" mass="13182" checksum="E71F46CB59085769" modified="2010-05-18" version="1">MGMRIVNSLEGHFFHYPAGGARLNLANMAASKWYNFHLLFECIYDDVHSPKLLWLKVKFKLFMLAAALKLLFRARSLDLFSLLRGIGSARAALREFHATRSIKTLIRRIDGAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ3</accession>
    <name>D4MAJ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_21650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21650"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1418"/>
    <dbReference type="HOGENOM" id="CLU_044041_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1302-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="367" mass="40367" checksum="A5AF25A0CE48ED13" modified="2010-05-18" version="1">MMLDWALGFALGIFTTLFLIVAFDVRLFSWRARDEDPFRGAIARRLATGPSVVAVGGGTGLSTLLKGLKAFTRNITAVVAVTDEGGSSGRLRTEWGVLPPGDVRNCMVALAENDNALKRILDFRFDRGDLAGHSLGNLLLLAVTEMCGDFRVAVEQMNHLLAIRGKVLPVTTEDITLVGRTRDGTRVRGELEVSERGRDLQEIWLEPQNASPLPDVMSAVDGADVILLGPGSLFTSVIPNLLLPEFARKLREAPAPKVYICNLMTQPEETEGMSVLQHLEWVAAALGTVPECVIVNSDPFPDDVLSAYHERGADPLYLDHHQRERIRRMGCICIEAPTALIMDAQLVRHDPQKLAAIVFRICRHMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK2</accession>
    <name>D4MAK2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_21790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21790"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1434"/>
    <dbReference type="HOGENOM" id="CLU_059988_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1311-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="231" mass="25287" checksum="9527E735D394E2E9" modified="2010-05-18" version="1">MGLKEHAAAIRERVARTAALAGRKPSDVLLVGVTKTRSVQEMQEVASLVDAIGENKVQEAQVKREAWGDHPTPPWRLIGHLQNNKARRAVELFDAVDSLDSIPLAERLDRIAGELSRRLSVLIEVNTAKEASKTGMAPEAFPALLDRVLTLPNLKLEGLMTIGPLTDDEVRVRQAFAELRGMAEDARGRCGLPLPVLSMGMSGDFEWGILEGSTMVRIGTALFGPREYKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL2</accession>
    <name>D4MAL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase, alpha subunit</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_21950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1449"/>
    <dbReference type="HOGENOM" id="CLU_034388_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1321-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="212" mass="22546" checksum="813873E851AC43A8" modified="2010-05-18" version="1">MFTGLVEAVGRVRAFTRGGLVHTLSIECPKIAPQLVLGQSVAVSGACLSVTALRGDAFDVEMMPETAERTWFRALQPGTAVNLERAMRLGDRLDGHLVLGHVDGTAVLREMTGEGTARRAVFRADPELLRGIVPKGSVALDGVSLTVIDALEAEFSVGLIPTTLRSCTLGAARVGSVVNLETDILGKYTERLLRGSRSGKGLTMEELRGLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAM8</accession>
    <name>D4MAM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22230"/>
    <dbReference type="HOGENOM" id="CLU_3118147_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1337-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="50" mass="5914" checksum="5B4B5EC83FAA656A" modified="2010-05-18" version="1">MKWTWPYILQQVFMGLAWCFVVWAAWAEIREIFAEKAALADGPEKEKPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAP3</accession>
    <name>D4MAP3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ORF">SY1_22440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22440"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1489"/>
    <dbReference type="HOGENOM" id="CLU_025574_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1354-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="342" mass="37942" checksum="A100E18395B4628F" modified="2010-05-18" version="1">MKRAVRKFLPALAVLLLCAGGAAFYFKVPGPLWERLLPVPEGEPVTVLVAPGTNARQIAQAFEDQGALEGSAGELARWMVHFGLDRRMQPGYYKVVRSAPWYVARQLREARPCLLRMTLIPGADAYSLREALSLDVASEGDALHQAVMDDANYPEAMRVKLPEDEPSRLAFLQPESYLVLERTPAELVRAASAQWWRRLGAAAARMTKQELHRAAVIASMVEREVLHDSEAPRVAGVIQRRLKDGMPLQIDATVVYAWKLQGRRLTRVLRSDLGVDSPYNTYRVSGLPPGPICVPGTAAWDAALSPEDGGDYYYVAGKDGYHYFAKTYAEHLRNVDRARSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAP6</accession>
    <name>D4MAP6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">SY1_22500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22500"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1494"/>
    <dbReference type="HOGENOM" id="CLU_091257_3_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBL28941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="171" mass="18445" checksum="83E5216C610412E5" modified="2010-05-18" version="1">MAPSGERVCLGVDPGLARVGYGAVARSGSRFRALEYGCIETSPKLSFMQRILQIYAKLGEQLERCAPAFMSVERLFFGHNATTAEFVWQARGVVMLLAAQRGLAVVEPKPNQIKLAVCGTGGADKRQVQRMTQRFLGLDRVPSPDDTADALAAAITGFALMRDEELRAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ7</accession>
    <name>D4MAQ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="10" type="ORF">SY1_22680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1512"/>
    <dbReference type="HOGENOM" id="CLU_078938_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="150" mass="16283" checksum="3572D7583B3ADA01" modified="2010-05-18" version="1">MQVILKADVNKVGSAGALVNVSDGYARNFLFPRGLAVEATPSKVAAWKEEQANKRKKEAKQLQEAEETKKGLQGKAVRIEAKAGENGKLFGSITTAQVAEALSRQYGRTVDKRDIKMDDVIKQPGSFPFALKLHAGVHADMTLSVTTQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR4</accession>
    <name>D4MAR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22770"/>
    <dbReference type="HOGENOM" id="CLU_1114537_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1375-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="249" mass="26818" checksum="019CF6F274CBE365" modified="2010-05-18" version="1">MSIKSAIDKLHQAFNLVLAFSLIAVTAGVFIFFLTTPEERGTTFWISMVSLAFALILGLLFSSKVALSDGREAPGNFSHLIVVAAYFIFVVGASIANVYLHFSTTTYFLIHVGGAAAFLLPLLLIHMAMLKPGGADRRDQREGRLSLSLKASHLQDLVKNLEFSLNLPGEDFSPLLRLADSLQYADPTPASRSTENVLIGALSALDGAVAALTNGTEADRVEKWQAVLAACHAAESALKQRNMEVINAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU2</accession>
    <name>D4MAU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23280"/>
    <dbReference type="HOGENOM" id="CLU_137228_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1403-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="112" mass="11725" checksum="D66684973A24D1EB" modified="2010-05-18" version="1">MDFKQQARDGKELMGKLAQAAPEVVGAFRSLNEVAHKERALDAKTKELIALALGVQARCIPCITAHAQGALSAGATREEVVEALEVTITMGGGPSAAHSAIALEAFDQLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU3</accession>
    <name>D4MAU3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">SY1_23290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23290"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1570"/>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="97" mass="10609" checksum="C7EC8A6DE84E026F" modified="2010-05-18" version="1">MNLKPLGDRIVVKVLSREEKTKGGIVLPDTAKEKPTEGEVIAVGTGKVLDNGQKLPIEVKVGDRIIFSKYAGTEVKLDGEDYVIFSERDVLAIVDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU8</accession>
    <name>D4MAU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAP-type C4-dicarboxylate transport system, small permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_23360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23360"/>
    <dbReference type="HOGENOM" id="CLU_1536901_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1409-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="177" mass="20760" checksum="89F898B53E9CE048" modified="2010-05-18" version="1">MKRFFENLRRLEFFLGAAGLSLSVILTFCQVLNRYWLHYEIMWIGDMALFIFIFTIYVAISYGAALKTHICVDILPDAIAQGNERKKALYDIFKSVVTVVMVLSMAPATWKVVKRSFQYPEYATLVRWFNMSWLVYAMGAMVVLVALHYAWHICEDVFLIRKSLWFEQNEKTVSRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV3</accession>
    <name>D4MAV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23410"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1583"/>
    <dbReference type="HOGENOM" id="CLU_060077_8_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1414-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="134" mass="15638" checksum="307A3F53FCFD7327" modified="2010-05-18" version="1">MVYTMTQACEETGMTYQGLKFYCNEGLVPNVKRDGRNRRVFDERDLAWIKGLSCLRDCDMSIKEMKRYLELCLQGVSSIPERKNLLEQKRRRLVERMAALENSIQYIDAKQRFYDEVLSGKRAYVSNLVPAGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV5</accession>
    <name>D4MAV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_23430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23430"/>
    <dbReference type="HOGENOM" id="CLU_3216634_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1416-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="44" mass="4935" checksum="0A80051F47184C68" modified="2010-05-18" version="1">MDCTGPVWRPPFEAGSPFKKTEEALKEIPAHHSERQADKGREGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX7</accession>
    <name>D4MAX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.81" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23840"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1439-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL29022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="354" mass="38838" checksum="7ACAFD58B0454795" modified="2010-05-18" version="1">MSQPSPGGTLRALRAHGANPEKLYAALGIPMPADVIDFSTNACALPWPDEAVGRAIDTARLASAYPDDECLALRRLIAAREGLALENVLVSNGSNEALYLLASFFAGRRTAVLQPSYGEYARALRAFGAEVEDVFSLDAAGGADLLILSNPCNPTGAYLPPDELARFAADHPDATLAVDEAYIDFLLTRKGERLDVRALPNVLLLRSLTKTYHLSGARIGYVLAGEGWIRRLGSRQPTWSVNAFAQALALAFMEDEGFLARLRTHYAEETPRLVRAVEAAGFRVRPSCVHYFLMETEDDEALIRGLMERGIVVRHTRNFPGIEGRCVRIATRTCQEDRRLAGALRELRERGVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ2</accession>
    <name>D4MAZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_24080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1652"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1454-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL29037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="299" mass="32549" checksum="8BABE8E1ED791C2F" modified="2010-05-18" version="1">MRSVHEKITEEDQAPLPPRNSLAKDAFLRLCQNRAALAGLIFLVFLTLTAVFADTLFDYQATCVKQNILARLQWPSLQHWFGTDEYGRDFLARIVHGSRVSLSISFIAVAFGLLLGGLLGAVAGYFGRTIDNLIMRLCDVFLAVPMMLMAIVIVAALGASIRNLVIALAVASVPTFARIVRSAVLTVRDMDYVEAARAVGVKTRRMLLRHILPNCIGPIIVQTTLRVAATISNTAALSFLGLGVAVPRPEWGALLASGRNFIRDNSYLACIPGICIMLTILAMNLLGDGLRDALDPRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6X9</accession>
    <name>D4M6X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rny</name>
        <name evidence="8" type="ORF">SY1_00180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00180"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1293"/>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="325"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="509" mass="56965" checksum="C8F360FF3C819339" modified="2010-05-18" version="1">MQLIIAALIFAAGVGVGYLILQAWDNTRLTGVKNQTLLMLQEATDAAERLKQDRLTEARDEVSRLRQEANRDAKERRAELQRVERKLEQREENLERKLDRVSHKEDELRLKQEAIEKRGADLEALIRQQGDKLEEIAQMTKEEAQEILLRKTEEDAQYLIGLRLKELEERAHREADRRARDIVVAAMQRCAVESAGEATVSVVPLPSEEMKGRIIGREGRNIRAFEMLTGVDLIIDDTPEAVTLSSFDPVRREVARRAMERLVVDGRIHPARIEELIDKATHDVEDEIISEGESAVLEMGIKNIHSELVRTLGQLKFRFSYGQNALSHSLEVAQIAGAIAAELDLDEELARRSGLLHDLGKAVDHQVEGPHAAIGADLAQRFGERPEVVSAIASHHDTLEVSSVYEVVVALADAISASRPGARRESLDAYIKRLEKLEELAMGFNGVSKAYAIQAGREVRVVLTAGKTDDGSVYKLAYDIARKIEAEMKYPGQIKVNVSRETRASEFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y9</accession>
    <name>D4M6Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliW</name>
        <name evidence="4" type="ORF">SY1_00330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliW family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00330"/>
    <dbReference type="HOGENOM" id="CLU_112356_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="161" mass="17686" checksum="BEB5968FAFCF2DF3" modified="2010-05-18" version="1">MSATTIATERFGEVSYGDEDVLAFPRGIPAFEDRHRWILVGSEDNAIKWLQNLEDPALALPVTTPDAVRPDYNARIPEDELELVGSMDPADLALLIVVSIPEGAPWNMTANLRAPILLNLKTRKAVQVIALNEEYPIRHAVFPDDVRTRMRSQAAAAGGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M711</accession>
    <name>D4M711_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_00800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00800"/>
    <dbReference type="HOGENOM" id="CLU_006855_3_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-38-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="447" mass="48864" checksum="30CB52A13694D5E3" modified="2010-05-18" version="1">MSDGHNERENWGSRIGFILAASGSAIGLGNIWRFPYMVGMNGGAAFLVVYLLLVATIGATVMLGEFALGRRMRKAPVPAFWQASGTHTWTLVGWMGTIGGSFIILSYYAVIGGWTLKYIVASLQDLMPQAVEGQSRDVFNHFVGSPTEVIAYFLAFMAMTVGIVLGGIGKGIERACKVMMPLLFLIMLVLIARAVTLPGALQGLDFYLRPDFSKLTWPALLDALSQGFFSLSLGMGIMVTYASYIRDEEHLPSSVAYVVFYDSLAAFLAGLVIFPAVFSMGLEPTQGVGLTFIVLPGVFARMPHGEIFSALFFVLLFFAAITSSMSLFEVTVAHGMDDLKWSRRKSSLVMGVIITLLGLPSAASLSGSPKLWGMDFLSAMDFLSNHIILPLCAILTCIFVGWRFLDRAEDEISNHGTYRFKLLRAWAWIIRIVAPVAIGIVFYKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M720</accession>
    <name>D4M720_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_00970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00970"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.368"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-47-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="326" mass="35790" checksum="A1AFACCDCEA32E22" modified="2010-05-18" version="1">MSDKPDKFIEVKHLKKYFTVSSGLLHAVDDVSLDIPRGRTLGLVGESGCGKSTLGRVIIGLIEASGGEVLFDGEDALKFEGAKRGEFRRRAQIVFQDPFSSLNPRMSVSQLIAEPLIINEVCRSHKELNEKIGELMDLVGLASRLTTSFPHELDGGRRQRIGIARALALDPDFIVLDEPVSALDVCIQAQVLNLLADLREQRGYTYLFISHNLSVVRYVSDEVAVMYLGNVVEKADNSTLFKSPLHPYTQALLSAVPVASVEPKKQRIILEGDVPSPVNPPAGCRFAGRCARRGDACTSETPALVEIEPGHFVACHRLKDQLVRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M736</accession>
    <name>D4M736_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-Methyltransferase involved in polyketide biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01160"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.386"/>
    <dbReference type="HOGENOM" id="CLU_069348_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-63-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016874">
        <property type="entry name" value="TcmP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028177">
        <property type="entry name" value="Polyketide_synth_Omtfrase_TcmP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="282" mass="32887" checksum="C28812CB5FE5AFB0" modified="2010-05-18" version="1">MNESRKASAGLGFKVPISETALLTLYFKAQETQRPDRLIEDPRAVEILEKLGVDMSRFRDKKMSQVGTIIRTRRFDRETRRILADWERPVVVHLACGLDDRFLRTDSGKGVQVDLDLPDVMEVRKRFLPPSERNPQIGASMFETGWMDELLERYPEHRFAFIMEGVLMYLNGTDIEGLFQNLAQRFPGAELHFDSVSTWMVRHSKMHDSIREYGDDVRFTWGLDGLRDIEGWDPGLKFVEVEYYINQELRRWGWAVLLNLIPAMAKGAKMLRYDIRQANERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M766</accession>
    <name>D4M766_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.734"/>
    <dbReference type="HOGENOM" id="CLU_034724_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-92-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008537">
        <property type="entry name" value="DUF819"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34289">
        <property type="entry name" value="PTHR34289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05684">
        <property type="entry name" value="DUF819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="392" mass="41445" checksum="238E385AA5286A62" modified="2010-05-18" version="1">MVITNGFTYIAFLMFVAGSLLALEKYARWKVFNVVPPLVWIYVLNMIFCTMGLFNSEACKTAYSALKNNLLYAMIFVMLLRCDFRKLARLSGRLIAIFLGCSVTLAAGFIVLYPVFKGFLGADTWGAVAALYASWVGGSANMAAMQAALPVDAGAYSCALALDTVCYSLWIALLLLAVRYSSKWNAATKADTSKLDALADTANAQVAAEKKLATGSDWIFLVGLSLAVSAASQWIGAEANAALKGAGFAMFDKGTCTTLFVTVLGLVCAMTPLGKLPAVEELSNIYLYAVVSLLASTATIVDLVAAPMWVVYGLLILAIHVALMFFLSKLFHWDLCMVSTASLANIGGAASAPIVATAYDQNYAGIGVLMGVLGAAIGNFAGLAMGALLKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M780</accession>
    <name>D4M780_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01820"/>
    <dbReference type="HOGENOM" id="CLU_2665781_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-106-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012454">
        <property type="entry name" value="DUF1659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07872">
        <property type="entry name" value="DUF1659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="75" mass="7937" checksum="B6D0224E3AA31518" modified="2010-05-18" version="1">MPVSSTLRRSTVALKLNAGKNPKTGSTMVKSCSLAGIRGGADPEAIVNVAELVAPVLAHPVTRVERTEVRTLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M789</accession>
    <name>D4M789_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1142"/>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-116-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="400" mass="43499" checksum="41EF53170B323976" modified="2010-05-18" version="1">MNDVIERIRELAGEFEPEVIALRRHFHSHPELSWQEERTTDRVQEELRKLGIETVHRGYDGTSSGLIADIQGGAPGKCVALRADLDALPVTEENDVEYRSQNEGVMHACGHDAHTAGLLGAAKILMQIRSELRGTVRLLFQPAEEAGDRSGARAMVEEGALHGVDAAFGLHVASIFPSGELLYRRGPCYAACDVWNLTIEGKGGHGSAPELAVDPTPAAFQIGSAFQTVISREVSPRDTAVLSVGCLETSSRAFNIIPERVKMVGTVRTFERSVQDAVESGMRRLSSDIASAFRCRAELDYQRSTAATFNDPAMTDLLIRAGTDLFGPEAMVEAPLNMGSEDFSCFAEAVPSTYLQLGTAAPDRPGTHRPHHSAKFDLDEAQLKRAAAIHAAFAWTYLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M792</accession>
    <name>D4M792_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02030"/>
    <dbReference type="HOGENOM" id="CLU_2023346_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-119-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="122" mass="13770" checksum="093D7CB5F3DC7DBD" modified="2010-05-18" version="1">MGTILSTWVVYFFLSLMICLRQRLISRRPALIKPLSDSHSSFLAGSLLICGCKPQMLRRSLMSRRGIVAASRRRWFIASVVDHDLDALDLFLCPCHSLPLHTQVSPKDLPAAAWDDIFSDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M795</accession>
    <name>D4M795_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Micrococcal nuclease (Thermonuclease) homologs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02080"/>
    <dbReference type="HOGENOM" id="CLU_046484_5_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-123-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01123">
        <property type="entry name" value="TNASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01284">
        <property type="entry name" value="TNASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="188" mass="21173" checksum="B4ED8304BC9D915D" modified="2010-05-18" version="1">MERMLKRLVLAFLALLAGWLGLEHWQGQTGDVLSAPVVRVVDGDTIVVSVEGSNRKVRLIGVDTPETVKPNTPVQYYGKAASDFTKRELTGRRVWLEYDAEPTDRYGRHLAYVWLTSPPESADEASVRRDMFNAQLLTGGYARVLSIKPNTRYRELFARLEQEARRTGIGLWGQEGRSTGRSGARSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A2</accession>
    <name>D4M7A2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_02210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02210"/>
    <dbReference type="HOGENOM" id="CLU_169492_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-130-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="88" mass="10236" checksum="2CDBE102AE078C3E" modified="2010-05-18" version="1">MHEDTTFSPTALEDFSYWAQNDRKTLAKIKALIADIHRNGLMSGIGKPEKLLGQSGEYSRRITTEHRLIYRLDEDRLKILSCRGHYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D7</accession>
    <name>D4M7D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid/amide ABC transporter substrate-binding protein, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_02660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02660"/>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-167-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="15"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="372" mass="40185" checksum="AF487C5C0A7BD5F5" modified="2010-05-18" version="1">MVLAVSGAACAAEGPIKIGYLAALTGDYAQYGITEVNMAKMVVSETNAAGGVLGRPIELVVYDTKTRNEDAVNAVRRMIESDGVCVIVGANTSGINIATAPIVNKGRVPQISTIGTNPLVTVDNKGKVRPYSFRICFTDPYQGALAADLAYNDLKKTKAAILYNVGSDYAHGLREFFTKDFQKLGGTVVADEGFRETDVDYRAQLTTIKNSGSDVLFLPGMGKDMALAIKQAQELGLDVTVIGGDGYGEFMNEIAGDAMKGTYWINHTYLGDPVMAPIFARYKETYHDECKEFVNGTMAYDAMWWVLDAIKRAGAAEGPAIAKALEETKGLKLNHATLTIDPEDHNPLNKAGIILKVGDDLNTEFYKKIEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D9</accession>
    <name>D4M7D9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ORF">SY1_02690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02690"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1748"/>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="347"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="499" mass="52864" checksum="FE79ED2A7F994B43" modified="2010-05-18" version="1">MVELKVRGGDAAGWSGGAVVLLLREEDCRSVPEVPCRDAVKELAARKDFTGKTGTSLRVPLLSGGVRNLFLVGLGNGEDEACNAEAVRNALTAALREAGRHRCESALVPMAHLNVGAGRPFGPEAPDWSVVVGEAAGLSGYAFDKYKERKEDDEEGPFALREVLVPGLDEAAARRGMTYAAAQVAARDLANEPGCVINPPALADRAQAMAEELGLACEVWDEARLKEERMGALLAVGSGSATPPRLIRLSYVPRGGKARGKVVFVGKGITFDSGGLDIKPASSMTTMKGDKSGACCVMGILRGAAEMKLDVEVHGILASAENMPSGSSFRPDDIVRARNGKTIEINNTDAEGRLVLADALCLASEMRPDAIVDIATLTGACAVALGNWRAGLFSRSDGLSEALLASARRRGERFWRLPAEDDRIAEKLKSPFADLVNSGQRYGGATFAALFLGNFVDRAIPWAHLDIAGVDFMEKAWGVYARGASAFGVRTCLDYLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E1</accession>
    <name>D4M7E1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein SY1_02720</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_02720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02720"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1751"/>
    <dbReference type="HOGENOM" id="CLU_117144_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-171-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="109" mass="11843" checksum="B770FB0C99ECD738" modified="2010-05-18" version="1">MIVTTTNDLEGWRVVDYLGIVSGEVILGVNFIKDFGAAIRNVIGGRSAGYEEELQDARERSLEEMQQRARALRADAVLAVRVDYEVLGPNGGMLMAACSGTAVRLARVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G0</accession>
    <name>D4M7G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="5" type="ORF">SY1_02970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02970"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1776"/>
    <dbReference type="HOGENOM" id="CLU_052662_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01078">
        <property type="entry name" value="arcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="407" mass="46072" checksum="2130F94DFFDA61FF" modified="2010-05-18" version="1">MKDIHVFSEIGRLKQVILHRPGNELSNISPDLMADFLFDEVPFLRGAMAEHDAFAAMLKSCGAEVIYLEDLAAEAIENAGVREAFVDEFIGETCVTSKDEIRMLKDFLLGIPKTRDMVLQIMAGTRRSSFPKRDHTSLVDFVDVEYPFVTNPMPNLYFTRDPFSLIGSGVSLNHMWSTVRNRETLFGKYIFKYHPRFKDSAIPFYYDRDIPYHIEGGDQLVLSDKVLAIGISQRTEARAIELFAERLFKGPDGFETILAFKFPAKRAFMHLDTVFTMVDRDLFTIHPEIQQHLEVIAVTMKDGELRFEYQGRALEDVLKKYLHLDKVRLLPCGGGDPVDAPSEQWSDGSNTFAVAPGEIIVYDRNVVTNKSLEDAGVKLHVIPSAELSRGRGGPRCMTMPVVREKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G1</accession>
    <name>D4M7G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein, putative amidase</fullName>
            <ecNumber evidence="5">3.5.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_02980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.10" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02980"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1777"/>
    <dbReference type="HOGENOM" id="CLU_055029_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-191-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047789">
        <property type="term" value="F:creatininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006601">
        <property type="term" value="P:creatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006602">
        <property type="term" value="P:creatinine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031034">
        <property type="entry name" value="Creatininase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04448">
        <property type="entry name" value="creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="257" mass="28900" checksum="CD6ADFF105FEEF13" modified="2010-05-18" version="1">MEQRNKKFIQNITWPEYAKAAKDGVLIIPVGSTEQHSQHLPLSVDVIISENFARILTEEIDAYVAPSIAYGYKSNPTSGGGPLFPGTIDLKGNTLVTLTKDILLEFIADGWKKIILMNSHYENQAFLAEAADLTIGKQQEEFPKVILTSWWDNVSQDIIPAVFDERPFRGWDLEHAAVTETSLMLYFAPELVKVELLSDDGIGDDVPRYQRYPVSKTLIPKTGALYTSMTSTAEKGKLITDDVIKNFLRFLKKEFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7I4</accession>
    <name>D4M7I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase class C and other penicillin binding proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03440"/>
    <dbReference type="HOGENOM" id="CLU_020027_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-214-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="344" mass="37259" checksum="6599817ABE88C8FD" modified="2010-05-18" version="1">MKDLKQDVRALLESYRARGSFTKAVCAVSKNGKTILELSMGCGLETFFDLGSVTEVYTTTAILHQEALARLALEERLDRLLPFAPLGPATRSRFERLTVRDLLTHASGIPAWYPFYARQGSFWDVLEHVLSVEPPAQGPVHSDVNFMILGEVVRAKCAGLKESLADLNAAIGASSTYGPVDPGICAETENGNRAEAQRCADMGLPFEGFRPADRPIVGTANDGNAFYFFKGVAGHAGIFASARALLKLGRIYLDGGSSGDREWLRHKAVEEAFRDHGGGWGLGWSLSDVFPKGVGHASLSGPSLWLTPDWRIAAALLVNPLTADPAPDLSDLRRQLHAMLLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L2</accession>
    <name>D4M7L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydrogenase and related Zn-dependent dehydrogenases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_03930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03930"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1871"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-242-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="351" mass="37553" checksum="E115740026BA6D21" modified="2010-05-18" version="1">MKGFAMLKIGSVGWIEKDRPKCGPMDAICRPLALAPCTSDVHTVWEGAVGERHNMILGHEGTGEIVEVGELVKDFKPGDKVIVPAITPDWNSLEAQGGYSMHSHGMLNGWKFSNVKDGLFGEFFHVNDPDGNLALLPENIDLKVAPMLSDMVPTGFHGAELADVQYGDEVLVIGIGPVGLMAVAGANLRGASRIYAVGTRPVCIEAAKFYGATDFIDYKGGTISEQALRLTKGRGVDKVIIAGGTVDTFAEAVKSLKAGGRIGNVNYLGSGATIDIPRVEWGVGMGHKAINGGLMPGGRLRMEKLSRLVSVGKLDLSPLITHPFKGFEHIEEALYLMKEKPKDLIKPVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M1</accession>
    <name>D4M7M1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">SY1_04060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04060"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1889"/>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="602" mass="66658" checksum="EB84A5452580C758" modified="2010-05-18" version="1">MRQENIRNFCIIAHIDHGKSTLADRLLERTGTVQSREMKNQLLDSLSLERERGITIKLVPVRMDYTSPDGKKWVLNLIDTPGHVDFAYEVSRSLAACEGALLVVDASQGVEAQTVANAYQAVEQGLEILPVINKIDLPSAREENAKQEIQDVVGLDASDAVLASAKDGRGIDEILERVVQRIPAPEGDAGAPLQALVFDSVYDNYHGVISYVRVVNGVIREGQNVLFMQTGSVYSVEEVGVFRPGFTPVEQLGPGEVGYIAASIKTLAEAPVGDTITEAARPAARPLPGYRKVKSVVFCGFYPVERDNYPQLREALEKLCLNDAAVTFEPETSVALGFGFRCGFLGMLHMEVVRERLSGEYGVELVATAPNVVYEVVTPSGAVIEAHRPSDFPDAGEIEEVREPYIKLSVFLPSEFVGKVMQLVQDRRGVYKSMDYLTPERVRLIYEMPLSEFIIDFHDKLKSQTRGYASLDYEFIGLRASDLVRVDVLVNGEAADAFSFICHREQAYHRGHAAVTKLKALIPSQLFEVPIQASLGKRVIVRVNVKALRKDVLAKCYGGDITRKRKLLEKQKEGKKRMKQIGKVSIPQEAFLAFMQVEGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N8</accession>
    <name>D4M7N8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_04320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04320"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1919"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-269-MON"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="329" mass="36241" checksum="9AD8D3C277BECA6E" modified="2010-05-18" version="1">MAILVCGGAGYIGSHNVRALLDRGSEAVVVDNLWTGHRPAVPDGVPFYEGDVRDAALMDRIFSEHKIEAVLHFCACSLVGESVEKPLLYFANNVGGMQSLLEAMVRHGLRQIVFSSSAAVYGEPSRVPILEDDETKPTNPYGETKRVMERMMHWVGERHGIRYVSLRYFNVAGAWHDGSLGEDHRNETHLVPIILQVPLGRRDCVTVFGDDYPTPDGTCIRDYVYIEDLAQAHLMALDYLAKGGESRILNLGSGDGYSVMEMINAARRATGRDIPVKVGPRRAGDPARLVADSALAGRVLGWRPQVTSMEDIIASAWHWHSAHPQGWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T0</accession>
    <name>D4M7T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05120"/>
    <dbReference type="HOGENOM" id="CLU_876479_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-312-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="317" mass="35425" checksum="5308CAA0307A2E41" modified="2010-05-18" version="1">MTELLNTFCRGRNIQLLWQPELETIPDRIAEGFVPIEMAEGTKSFVDFRCLDHHNDYSHLPSACVTALKFYGTLGSDSPVRLMVNHTDADCVLTGVTLLGLLPRKLLERLNPEVGVLDTDPLSVDFGDLLYGNAIRLWKVGMMSTKKSGWSWLYGMQLFLDIFNHFTYYEGKTGELEERERARREKAFQDYDKAVTGPSGKVLLVAPSTVKGYDVQFFRQRAFPATSLEGWRHWCVVSHVRKVGNVMLSCPNKEVAERAFGSGGLKNVFPRLPEIEGKEWGGREAVGGSPRGIVVPAELLGSILTILEDSLLTKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W0</accession>
    <name>D4M7W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerate 2-kinase</fullName>
            <ecNumber evidence="3">1.1.1.81</ecNumber>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.81" evidence="3"/>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2043"/>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-342-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="311"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="423" mass="43312" checksum="B06C1BD83905C1B7" modified="2010-05-18" version="1">MDKLREDALEIVRRAIDAVLPEAAVREALGRGELAARLRETGRGRVILAAIGKAAWRMAQAASEALGDRLAGGVLITKYGHSLGEMRGIKAFEAGHPVPDENAVRGTEALLRRVRGLSPEDTVLFLVSGGGSALFELPAEGVTLKDLADVTGQLLACGADIVEVNAVRKHLSAVKGGRFAKLCAPARVLTVALSDVLGDRLDSIASGPACPDASTSEDALRVVEKYGLALHPRLTEALKRETPKKLDNATAVAAGSVASLCAAAGRAAAALGYTPLLLTSTLSCTAREAGAFLAAIAREVRASGRPIASPCVVIAGGETVVHVTGKGRGGRNQELALSACRGIRGLRDVVVVSVGSDGTDGPTDAAGGIVDGTTAEALGARGMDVEAVLRDNDAWTALKAVDSLVITGPTGTNVNDVSFALMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y6</accession>
    <name>D4M7Y6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="1">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nnrE</name>
        <name evidence="3" type="ORF">SY1_05910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05910"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2081"/>
    <dbReference type="HOGENOM" id="CLU_024853_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="1">
        <location>
            <begin position="80"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="1">
        <location>
            <begin position="156"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="235" mass="25392" checksum="741109046CA1E925" modified="2010-05-18" version="1">MIVEGFGVEELAGESLIREVVYRGVSSPETVGREKMRRMEERAVKKFGIPSLLLMENAALAVVHEVEDYSAFAVVCAPGGNGGDGLAVARHLCLLGRDVRVYLVGDPEGGSADFRTNLEIMRRMSPESIYALTDESFKDFEYALKGCETCIDAMFGIGLNRPVEGLPRRAIEAMNRYALHIVSVDVPSGVDADTGEVLGAAVCAHKTVTFHRVKPCLDLAPQYAGDVVVAYVGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z1</accession>
    <name>D4M7Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidases/acylaminoacyl-peptidases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_06030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.071"/>
    <dbReference type="KEGG" id="sbr:SY1_06030"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2088"/>
    <dbReference type="HOGENOM" id="CLU_008615_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-373-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="450"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="658" mass="73520" checksum="148CAC66AA584B83" modified="2010-05-18" version="1">MEKNELNRVQFHDLMKYRFISSPRISPNGAKAAFAVHQGDLEGNRYLSCLWLCDLTSAQTSQLTFSGTERAFCWSQDGRDLIFVSGRSPQPGEPEPAPDAPRDSRLYRMNVAGGEARFLAALPRTVTALWDLGDGRLLLKTTDPRKGERFEDADYMVFQQIPFNSNGKGFTAQQRSRLSLLTLEGSKLEDLTPETMDVRQVRPSPDGTRVLLTGVDYEDVMPLTTGVWEIDLSSKTLKERLPQGQYAWGCAAFFEGEVLLAGTDMKRHGLNENKRFFMAREGAAPRCLTPDWDRSLHNSIICDCRYGIGPIGESFLVDGDKAWFISTEGWRSRLSTVDAQGAVVQVTRMLRSVDDFDVKDGRAVVVGLEGLSLQELYLIEDGAERRLTGLNTAALEGTDLSVPEYVRLENGTPDGLDCWYMRPIGFEVGKKYPAILHIHGGPKATFSDVFVHEMQCWAAEGFAVLFCNPRGSDGKGGGFDDIRGKYGTVDYEDLMAFVDWAVQTLPFVDGDRLGVTGGSYGGFMTNWIIGHTNRFRAAATQRSICNWVSMTGMTDIGYYFDPDQHGADVGDSVETLWDRSPLKYANQMRTPTLVIHSDEDHRCDLGQGLQLFTALKRGGVESRMCVFKGENHELSRSGRPQPRLARLQEIARWLKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M804</accession>
    <name>D4M804_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAP-type C4-dicarboxylate transport system, small permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_06220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06220"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2108"/>
    <dbReference type="HOGENOM" id="CLU_086356_3_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-386-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="165" mass="18500" checksum="839113A7EE78F8FB" modified="2010-05-18" version="1">MKKTLNALLNLDTLVAGVGLVLIVVMTVAGVFMRKVMGRPFAWMEEMQIFFFIWTIFFGGSVAFRTGSQVSIDLIAVRLSPRARCILDIVDYLITVLVLAYLTKGGYQLMMSVTKKVTPYFKISYSLIDLAVPIGCVLMIIQYSLIAWDKFLRNREAAQEEGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M809</accession>
    <name>D4M809_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2114"/>
    <dbReference type="HOGENOM" id="CLU_1145884_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-391-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBD_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="242" mass="25316" checksum="04DB9B8446E7AEE6" modified="2010-05-18" version="1">MVSLLIVADDFTGALDTGVQFVARGASTRVVTDLDRDFSRDEAQVLVLDTETRHLAPEAAYAAVHRAVSAALRAGVPYIYKKTDSGLRGNVGSELAAAMDAAGVQSLPFVPAFPSMGRITRDGVQYVDGLPLDQSVFGRDPFEPVRFSRIGDVIAQQTSKAVFVRRPGEPGMGQGIQVYDATTDEDLKLTARALGPEGLRLSAGCAGFASVLADLLMPAARPAAVPSLAPGTSSWPAAASTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M818</accession>
    <name>D4M818_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted permease, DMT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06410"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2127"/>
    <dbReference type="HOGENOM" id="CLU_033863_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-400-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="150"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="294" mass="31381" checksum="53643E4FF92AC8B4" modified="2010-05-18" version="1">MKRSAIAGYAAALTSILIWGTTFIVSKVILEDFRPVEVILIRMVLGLVALFLVSPRLPRVRTVPEELSYAVAGFCGIVLYFLLENTALTHGLASNVGVIISAAPFFTATLNRLFYRSDRLQVRFFVGFALAMTGIGLISFNGVRMQISPLGDLLALGAAASWGLYSVLVRRAGGFGLSTLQATQRIFLYGVLFLAILSPFLGLRPNLAHLVQPKFFLPFLYLGLGASALCFFAWNFAVEALGPVRTSVSAYLIPVVAVAAGALALGEPVTPLSLLGTGLILGGLAVSEWRAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M821</accession>
    <name>D4M821_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06470"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2134"/>
    <dbReference type="HOGENOM" id="CLU_356719_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-403-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061522" evidence="2">
        <location>
            <begin position="30"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="786" mass="87369" checksum="686414034B09260A" modified="2010-05-18" version="1">MSKTVRLVSGALVLLAALAAGGAAWGAVADPIHDYPSFNDYDDADRYYTFGDHTTEYGYHYQLRDVSGARDGHTVAGAQWFATSYENYLWRYVNEDLNGRLLYRRTLGGETPEVPLTTSADLLYDFEAVYIDEPQPYPAYPDTRYRDACMDPIESIALVLPEGRGQFKVSLANHYARHFPYWWRESGSGRTPINPSPVLSGDIVSHDVISRDVMEDVLLSAEGYAVSVQPNRPQRVMPGESMTANVSLTAENPEAYGSRLGYIAFRQSASFDTGYVGWRESLHVPVVVANVHDGPASDPGNELYFDMMIFNRTLSGDTVVGMGDIEKRIQFRWGVDREMTQDLGALYMMRHSLNSGLPSYHLETRITNRTGTRYRLQRYDMIGGPRDNTGSGDVGGGSWDMTARYTFRDIRPDHWKYDLTPDLYGSLPDHFQLDAHSQIAPGLVTVYKNRVGTGYNTLNTSYGTSESFRLYPFSEARHHDLRLSYRRVGGMALTGGASEATGRWRVQGFRWDQFADVVQNDEQTTYELEKLMGKPASLGSSAVGASDAYVRSSALNAFEIKTDVPAGLVSMDVSMDVVVSKDVSGDVVQMVSRDVPATIAVQPMRVRLRIPRREQILVGRWEQLSEAADGKALLKQFMRFGTVWLRSGRADERDTNLFTAISQRGVDPAECVSAFLYNDELYLDFILLLADAKSPREGYTAYLRTFRDDGIPYILIGDGAADGVWNLGLYVDAAGANPESGRSSDDVNPRPQEKEKEEGGGCNAASGLGLILSAFVGALFLERRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M828</accession>
    <name>D4M828_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_06550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06550"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2144"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-410-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="337" mass="36595" checksum="7946689C21DE7C97" modified="2010-05-18" version="1">MEKLIEIKDLAIHYETDDGVVKALNSVSLSLVKGRTLGVVGETGAGKTTLGKGVLRLIPSPPGRIVSGSVLFEGQDLLKLSEAEMRKIRGRSISMIFQDPMTSLNPVMTVGDQIMEVIQAHKNLRRQEAWQEACRILEMVGIPGQRGREYPHQFSGGMRQRVGIAIALACAPTLLIADEPTTALDVTIQAQVLEMIRDLKKALGTSVILITHDLGVVAHNCDYVAIIYAGTLMEYGALREIFKSPQHPYTIGLFGSIPSLERKADRLRPIPGLMPDPTNLPPGCPFSERCPHSAEVCSREVASRNPPERSACVRPVVWLNPSAALGGTSPFRGGNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M860</accession>
    <name>D4M860_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_07050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07050"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2192"/>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-443-MON"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="14"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="180" mass="20067" checksum="22675D72794E0698" modified="2010-05-18" version="1">MAKEYRLGEVLLSRERIAERVAELAREIASDNGGRRELLVVGILTGAVFFLTDLVREMPDDLDVHIDFMSVSSYADATKSSGVVRILHDLKNSVEGIDVLIVEDIVDTGLTLSYLQDLLRARRPASLRTCVLLDKSARRETAVKVDYCGFEIPDAFVVGYGLDCAGRWRHLKDIRSVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B2</accession>
    <name>D4M8B2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">SY1_07890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2281"/>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_0"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="51"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="427" mass="45988" checksum="9ED0D989FDF372BE" modified="2010-05-18" version="1">MILIQNGRVIDPKSGLDEVLDVIVQDGRIAGMGKYARGGEFTEVIDAEGCTVAPGLVDTHVHFRDPGLTYKEDVATGAASAAAGGYTTVICMANTKPPLDDAEALKDLRRRESDLPIHVLNTACVTRGMKGQELTDMDALKAAGAIGFTDDGLPIKDVKLMMRAMERARELGVPISLHEEDPDLIGSPGINQGRISKEVGVPGAPAVAEETLMARDCLLALHTGARVNIQHLSSGVSVEVLRLMKRLGADVWAEVTPQHFSLNEEIVLEKGTLAKVNPPIRTEEDRYQLIRGLKEGVIDIIATDHAPHASEEKAQDLLHAPSGMIGLETALALGITNLVRKGHLTLLELLEKMTARPAELYGLSCGSLREGGDADLVVFDERESWTVGSRFFSKSSNSPFTGMTLYGRVKHTLCGGRVVYTDGKDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E0</accession>
    <name>D4M8E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein, possibly involved in motility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_08350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08350"/>
    <dbReference type="HOGENOM" id="CLU_173020_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-529-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="79" mass="8808" checksum="7E1FF13D3AF1F878" modified="2010-05-18" version="1">MIEVHRLNGERFLLNSDMIETINVTPDTVVRLLNGHRYIVREGIDEVCEKIIAFRKLAGYTCIVANSADEVEDSEGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E1</accession>
    <name>D4M8E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenine specific DNA methylase Mod</fullName>
            <ecNumber evidence="5">2.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_08370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32612">
        <property type="entry name" value="M.SbaSGP1ORF8370P"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.33"/>
    <dbReference type="HOGENOM" id="CLU_020164_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-534-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015855">
        <property type="entry name" value="TypeIII_Mtase_mKpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="59"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="574" mass="64910" checksum="B304761920814A44" modified="2010-05-18" version="1">MPTLEWIGKDKVINHHQEVPFRVLEKKYTVGADESDNLIIRGDNLEALKALLPRYEGRVKCVYIDPPYNTGNEGWVYNDNVNDPRIRRWLGAVVGKEGEDLSRHDKWLCMMYPRLRLLHRLLSPAGAIFISIDDAEYSNLKAVCDEIFGPDCFVSNISWQRTYSTRNDSKGIVNEVEHILTYSRRPGWNPNKLPRTEEMDAKYRNPDNDVALWRSDNPFAPGAATHQGMVYAIQHPFTGEMIYPTNGRCWTFGQDQMLEIMSGWTAYKLQDLHDEEARAIVCGVAAEEVRPGVQAIVLAVPPEKAAADARKVYKRGQWPRFYFTKGGKGGITRKTYLDSVGGRLPTNLWTYAETGHTDEAKKEMLAIFDGRATFDTPKPRRLVEFVLKIAGDPDSIILDSFAGSGTTAHAVLNMNKADGGRRRFILVEMMDYAESITAERVRRVINGYGGTEGTGGDFTFCELGPTVMTAEGLINPRTPTERLMEYVWYTETRQPWAGAPTDASPWRLGEWNGTEYYFYYEPDRPTALDEAFLRTLPAGPAARVIYADICTLSAAKLKKYGVLFKKIPRDITKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8F6</accession>
    <name>D4M8F6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">SY1_08610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.57"/>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="125" mass="14195" checksum="1B6EC36056DFAC34" modified="2010-05-18" version="1">MARISGVDLPREKRIEIALTYIFGIGVPSARKILAATGVNPDVRVKDLSEDDAQKLRREIEEHYVVEGDLRREVSMSIKRLMDIGCYRGLRHRLGLPVRGQKTKTNARTRKGKRRTVANKKVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G3</accession>
    <name>D4M8G3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="11" type="ORF">SY1_08690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08690"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.65"/>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="173" mass="18244" checksum="035E7F3C296736A1" modified="2010-05-18" version="1">MIKKRIDAKSLDLKERVVAINRVSKVVKGGKRFKFAVLVVVGDGDRYVGAGIGKAKEIAEAVRKGIEKASKELVAIRRNGDTMPHPVTGCFGAAKVLLKPAPAGTGVIAGGVVRAIMELGGVKDVVTKVVGRTSNSINVAWATLEAIKETRTADEIYKLRGRKPAEPASASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H5</accession>
    <name>D4M8H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplW</name>
        <name evidence="6" type="ORF">SY1_08840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08840"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.83"/>
    <dbReference type="HOGENOM" id="CLU_037562_3_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="98" mass="11088" checksum="57E00D8D894C967D" modified="2010-05-18" version="1">MSLSAHDIIIRPVVTEKSSALMELNKYTFEVRRDVNKIQIRKAVEEAFKVKVLSVNTINVKSKPKRMGASVGRTRSWKKAIVSLPQGQRIEFFEGASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I1</accession>
    <name>D4M8I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative alkyl hydroperoxide reductase F subunit</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_08950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.94"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-574-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02974">
        <property type="entry name" value="AhpF_NTD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017561">
        <property type="entry name" value="AhpF_homologue_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044142">
        <property type="entry name" value="AhpF_NTD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03143">
        <property type="entry name" value="AhpF_homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="6">
        <location>
            <begin position="466"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="541" mass="58116" checksum="4CEC5C264653AF03" modified="2010-05-18" version="1">MDDRNFYDVVVVGGGPAGLTAGLYLARACYRVLVVEKETFGGQITITSEVVNYPGAGRTDGRALTDTMRAQAESFGAEFLMADVTNLELDGDVKKVHTDRGVFSCFGVLIATGAHPRVLGFPGETEFRGRGVAYCATCDGEFFTGKEVFVIGGGFAAAEESVFLTRYARHVTVLVREDAFTCAEATARGALEHPKVTVLTNTQVVEVSGDTALRRIRYKNSKTGTETVFSAEDGDTFGVFVFAGYVPATDLVKGKVELNPQGYVVTDRSQKTSLDGVYAAGDVCVKNLRQVVTAVGDGATAATELERYAAAMQAKTGIHPKKPVRTAAAPTREAKREAPAEGGLFSEDMRQQMEAVFARMEQNLILELFLDDRPVSRELQGYMTELAGMTDKLTVRTGTGLPEAELPCVRVLKADGTDTGLAFHGVPGGHEFTSFMLGLYNAAGPGQSLDDTTRARIRAIDRKVGMKVLVSLSCTMCPELVAAAQQIAALNPSVTADVYDINHFGALKERYNVMSVPCLVIDDDRVTFGKKGVQQLLDEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I7</accession>
    <name>D4M8I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_09030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09030"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.107"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-580-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="343" mass="38165" checksum="DEA9F2B0277558C1" modified="2010-05-18" version="1">MNDRMNAMNSSDFLLRVSDLRTSFFTPAGEVKAVGGVSFNVKRGEVLGIVGESGSGKSVTMLSVLGLLGTSGRVVGGSIDFDGQELTRMRLRDLEELRGKRISMIFQDPMTSLNPVLTVRWQMEESLRRHRIPCDRHDRAVDMLKRVGIVPAERRLTQYPFQFSGGQRQRIMIAMAMICNPDLLIADEPTTALDVTVQAQILELMKELQGQFGTSIILITHDLGVIAGMADRVLVMYGGRIMERGTRREIFYEPAHPYTRGLLRSVPNPEELVRQRLIPIEGQPPDLLNPPAGCPYAPRCPEAMRVCMEYSPDRTELTGSHNAACWLLNRPAGSAADRKEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J0</accession>
    <name>D4M8J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_09100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GT83">
        <property type="family name" value="Glycosyltransferase Family 83"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09100"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.113"/>
    <dbReference type="HOGENOM" id="CLU_019200_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-583-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040845">
        <property type="entry name" value="Arnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18583">
        <property type="entry name" value="Arnt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="8">
        <location>
            <begin position="49"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Arnt_C" evidence="9">
        <location>
            <begin position="456"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="560" mass="62294" checksum="5E58431D393307AA" modified="2010-05-18" version="1">MRPGGREGPRFLRWLAAARPLIPWAVLALLAVAVYFWGLGRYGLIDPDEGRYAEIPREMIESGDFVTPRLNYVKYFEKPALHYWLTAASFAAFGQNEAAARLFPVLFGLGGCLLTFVAARRMTGSARAGAAAAAVLVSSVLWYALSRLNVIDMTLTFFFTLAMLGYWLWFRGGEGAGRRPLLLFYAAMALATLSKGLIGVVLPGGIAVLHLASLRRWRAIPRLFSPWGIALYFAVVLPWFRAVCAANPDFFDFFFVHEHFTRYLTTEHGRYEPFWFFVPILLGGLVPWTGMLWDAFRAARGRGGLLRREDGLFLSLWFAVPLAFFSLSGSKLVPYVLPCLPPLAVLIGAAVEGILRGGAPAMRAGRRFACLNALILLPIVLAGAVYPALRPEDAYLRAATNPFCFVLTAFCLASFVLLRARTRGFLLLCLLALTALFVAGTGFDLMAARDSRRPIAAMLRERLRADDTVVAYGDLMQGLSFYLGRRIAIAGGRGELDFGAAQEEDPRWFLNAEQLRRLWNGPDRVLLAASRRRLEELTRDLGREPVRLGETEKEILFTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M6</accession>
    <name>D4M8M6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_09770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09770"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.178"/>
    <dbReference type="HOGENOM" id="CLU_2568908_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-620-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="81" mass="8816" checksum="373BF2D600AEDCF1" modified="2010-05-18" version="1">MAIAAIIGRPNVGKSSLFNRLIGRRESIVDDAPGVTRDRIYGEAEWRGRSFYVIDTGGNPGGGVRLQRRHPRPCGGGHRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M7</accession>
    <name>D4M8M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Na+-driven multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09790"/>
    <dbReference type="HOGENOM" id="CLU_170976_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-621-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="113" mass="12138" checksum="9183A8D084A99597" modified="2010-05-18" version="1">MTTDPEILSLSVEVLRVELLAEPLYGAHIVAAGVFRGAGDTLFSSLMTLASMWGVRLPLAAFLAPRRGLRGVWLAMCVELCGRGAIFLARLAGPRWQRRGLAAATERSGGTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N8</accession>
    <name>D4M8N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenine specific DNA methylase Mod</fullName>
            <ecNumber evidence="5">2.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_09940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32613">
        <property type="entry name" value="M.SbaSGP1ORF9940P"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09940"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.194"/>
    <dbReference type="HOGENOM" id="CLU_020164_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-632-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015855">
        <property type="entry name" value="TypeIII_Mtase_mKpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="121"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="642" mass="72393" checksum="5E5D2ECEF0BCB9C7" modified="2010-05-18" version="1">MAGRMKMEWADGVARNIERIGALFPGCVTEARGADGRLRAAIDFERLRQELSDEAIARDEAYAFTWVGKRAAIAEANRPIRKTLRPCPEDSVDWDATENLYIEGDNLDVLKLLQESYFGKVKVIYIDPPYNTGSDRFVYSDTFAVSEEEYLERSGAKGEDGTVLFRENNFANPRFHSDWLSMMYPRLLLARNLLSDDGVIFISIDENEVSNLQKLCNEAFGERNYAATFLWTRTNTPPALSCKCRKTVEYVLAYEKRRSALKYFGAPLDGGDAPLLNAGNPEKALRFPSGSIHFPFLRDGVIPAGEKGRVWLLDELRVEDGVNANAVRLAGEFKWEQRTLEAEVRRGTCFVVKSDRFAIRFQRRNLEDAYKTPTNLLNVELNREAAVGTNETALRELEELGLGKCFDYAKPLSLVQAVARMVCAQDKEALVLDFFSGSGTTADAIMRMNAEDGGRRRFIMVQIPERTAPDTVAFKMGFKDIAELGRERIRRSGARIGAKEPDGARRTDVGFRVLRLDESNMRDVYYAAGEYRQSLLPALASNVKPDRTDMDLLFGCLLEWGLPLSMPHHSEEVEGCRVHTWNEGDLIACFAEDVPDSVVREIARRRPLRAVFRDAGFRDSPSRINAVELFKALAPNTRLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P1</accession>
    <name>D4M8P1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_09980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09980"/>
    <dbReference type="HOGENOM" id="CLU_169492_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-635-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="64" mass="7849" checksum="F89BB01E5B07580F" modified="2010-05-18" version="1">MKKQWDERAWEDYLYWLEQDKKTLRRINKLITDIERNGYDGIGNPEPLIGNYSGYWTPNHRQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P7</accession>
    <name>D4M8P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family (UPF0150)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10070"/>
    <dbReference type="HOGENOM" id="CLU_182997_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-641-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="78" mass="8638" checksum="B82203F12F7CFE1F" modified="2010-05-18" version="1">MATYTACYTKIEAGYMGQLLEWPEVITEGSTLEECRAMLLDAAQEMTRAYLETGQVPPQAQVLFEPLPVAMEKVSHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P9</accession>
    <name>D4M8P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator/sugar kinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.212"/>
    <dbReference type="HOGENOM" id="CLU_036604_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-650-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="322" mass="33189" checksum="8E9F5FEE274B6612" modified="2010-05-18" version="1">MTYYVGVDVGGTSVKIGVVSSAGSIVSEVAIATGAERPQEVVLQDILEGVRQAVAASDLGWGKVRAVGVGCPGMVRAEEGTVLYNNNLGWRDFLLGPMLTEALDLPARVENDANAAALGEVVGGCARGATSAMIITLGTGVGSGFVIDGRIWAGYNSAACEFGHMVIVRGGRPCTCGRRGCFEAYASATGLIAMTNEAIATDPEGAMAEMARREGRVGGHTSFVAAEAGDPAAMRLVDEYTDYLACGVANLVNGLQPEVVGVGGGVGKQGERLLVPLRRKVSAELYGRDYEDDRATRLVSCTLGYKAGLVGAAMAAKVAYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U1</accession>
    <name>D4M8U1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion-translocating oxidoreductase complex subunit D</fullName>
            <ecNumber evidence="10">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Rnf electron transport complex subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnfD</name>
        <name evidence="11" type="ORF">SY1_10940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10940"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.304"/>
    <dbReference type="HOGENOM" id="CLU_042020_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-692-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00462">
        <property type="entry name" value="RsxD_RnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578:SF0">
        <property type="entry name" value="PTHR30578:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="10">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="319" mass="33060" checksum="542C42F75582CD5A" modified="2010-05-18" version="1">MTERDLKLVVASSPHVHSPLSTQKIMGLVIAALLPAGAAGVHFMGWRALVVIAVCVAASVAAEYLWQRATGQRVTVSDLSAVVTGLLLAYNLPPSVPLWMAACGAVFAIIVVKQFFGGIGGNVMNPALAARAMMLISWPVAMTDWSLDGVSTATPLAAMKALSGAGASAAPGPSCSTADLLLGNVGGCIGETSAALLLLGGAFLVWQEVISWRIPVIYTLTAALLAALFRHGGGMMPLQEALTGGLLLGAIFMATDYTTSPMTARGQVVFAVGCGVLTALIRRFGGYPEGVSYSILIMNATVPLIDRVTKPRILGEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V6</accession>
    <name>D4M8V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium pump decarboxylases, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_11130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11130"/>
    <dbReference type="HOGENOM" id="CLU_1893142_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-707-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005899">
        <property type="entry name" value="Na_pump_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04277">
        <property type="entry name" value="OAD_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="134" mass="13975" checksum="AD5607A63E7747BC" modified="2010-05-18" version="1">MNAMHFDGLSGAAYVSLVAFSIVFIVLLGLTLVIFAMRFFAAGERPKPDDGATAPQRPQSASAAPAARAEGAQARVVAAITAAILAATGGMGRVVSIAPETVDAVQKGARWTRAWRASGVLNLISRSVDRGWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X5</accession>
    <name>D4M8X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_11450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11450"/>
    <dbReference type="HOGENOM" id="CLU_044208_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-726-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061751" evidence="2">
        <location>
            <begin position="27"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="244" mass="25785" checksum="CB6DB802CA901AEE" modified="2010-05-18" version="1">MLVHWKKLVLLAALCGALCCAALAFAAPLRDAFGGFVTWLVETIGRLGYAGIAALMFLESSFFPFPSEVVMPPAGYLAWRGEMSLWGAIAAGIVGSVLGALFNYWVAVRLGRPLLLKYGRYFLVSEESVSKAEGFFIRHGHVSTLVGRLVPVIRQYISLPAGIARMPLGTFTAFTALGAGGWVVALTLVGYLLGGHQEGLGRYLHVISLGCVGVALLIAAGYAAWLCLRRRASKAAGPGGLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X6</accession>
    <name>D4M8X6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">DNA ligase</fullName>
            <ecNumber evidence="9 10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ligA</name>
        <name evidence="12" type="ORF">SY1_11460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9 10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11460"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.351"/>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="601"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="45"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="683" mass="74817" checksum="7417C1F39B7653E1" modified="2010-05-18" version="1">MNDVGGVDRGLERGQDDAARMAELYEELAHHARLYYDEDAPEIPDAEYDALVRELAELERAHPDRVRPDSPTRRVGGTVLEGFEKVRHERPMLSLDNVFSAGELSSFLERIRGDVPEDDWTFTCEMKIDGLAVSLLYEDGRFVRGATRGDGRVGEDVTENLRTLRTLPMRLKGAPAGRVEVRGEVLMTWDRFNALNERREELGEPPFANPRNAAAGTMRQLDSRIVAERGLDAFLYYLVDAPSLGVTRQGDALEWLAERGLPIQPAWRRCASLAEAEAFIVEWQERRFSLPYVTDGAVVKLDDLTLWDGLGATAHAPRWAVAYKYPPEEARTRILSIDVSVGRTGALTPVANLEPVRLAGTVVQRAGLHNEDEIRRKDVRVGDVVRVRKAAEIIPEVVAVEKECRTGAERPFEMPERCPACGSEAVRLPDEAVLRCPNRASCPAQLKEGLRYFASRAGLDIRGLGERLAEQLIDSGRVKTLSDVYDLPEEDWASLDRMGEKSARNLMGALEASKDRPLSALIAALGIRFVGRRVAELLAERFGSMDALSAASEAEIADVEGVGPVIASSVEAFFRDEANLALVERLRERGLNFSSGDAAGHEGTELEGKSFVFTGELSSMKRAEAEALVRAHGGSASGSVSSKTSFLVAGAGGGSKRRRAEELGVPIVSEEDFLRMIGGSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y5</accession>
    <name>D4M8Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.397"/>
    <dbReference type="HOGENOM" id="CLU_051402_4_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-737-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010087">
        <property type="entry name" value="Flav_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01753">
        <property type="entry name" value="flav_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="140" mass="14339" checksum="357875C2001A09D3" modified="2010-05-18" version="1">MSKVAVVYWSGTGNTEAMAKAVAEGAKAKGAEVDVLTCGEFSADKAAGYSGIAFGCPAMGSEVLEESEFQPMFDGVKDKCAGKKVALFGSYGWGSGEWMESWESDCKAAGIALAAPSVTCNEAPNAEGLEACKELGASIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y9</accession>
    <name>D4M8Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11720"/>
    <dbReference type="HOGENOM" id="CLU_023081_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-742-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="165"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="297" mass="33084" checksum="A159408988AE1D44" modified="2010-05-18" version="1">MGIHSNATPPARGSFHRTMRFHQCLAFSPLFCRAVGADGTVGTKKGRARRVFFPGCSLAAYAPEHVLAAWQYLCERMEGVGALLKCCGKPLKLMAMTGEFRRRFDAVRRDLDLMGAEEVIVACQNCYTIFRHFDEDRRVRSFWTILAEMGLPEGSRGSARGLEVSIQDSCVTRGVPEIYDGVRTVLGELGATVREMDCARDRARCCGCAPMIAVGDVRLGYEAMKKRAEESPCGTIVSYCASCRSAMRTGGRESLHLLDLIFGGGWTDRSTPPPDRSLRSWLNRWRTRQRLGKLVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z3</accession>
    <name>D4M8Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11760"/>
    <dbReference type="HOGENOM" id="CLU_1756153_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-746-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="148" mass="16467" checksum="293241748FA8E997" modified="2010-05-18" version="1">MRQDLLPRGLRLLTHLLTLAQLALFAGGLWLHRLSFRRAGVNHHLSFMKRTVEKLYLTDAVTTALTVVALGVAFFLFCFARRAIGERGWRVMATPAVGAVLALAFVVELWLPSLKALPAWPVLLGVTALAFVLQVVKTLLKARIERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M926</accession>
    <name>D4M926_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12160"/>
    <dbReference type="HOGENOM" id="CLU_031290_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-779-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061754" evidence="1">
        <location>
            <begin position="29"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="472" mass="51466" checksum="C09012847265C254" modified="2010-05-18" version="1">MYRKAMKRWPSGMLLFALALVLGAPASANLLYTVHDNNYASTSVGKIVGDTAIVLATNVGGNWGQVIFPFKRGAADRVAVTLYPNSNPYYPGDEVRIYDPASLNWSSPESTLTHVRLKNIRALAFMGGHPYGIGYDCTPFAFAYSEDPVRRSAKVARWNHMWGTTYWPDNLYTHLFQYESPSGYTANGEGLAAHGSFVYALFKSYTGNYPNFVYSPNKLVKLNAELGQVGALDLHGKNTDGSIPGAYCQSGSTLYLTSWGGLHFFISNWHPESRIEKVNLNGMSTETLVTGQQMHDNDPSWKHHFTAIALHGNTAYVQAATWKEFPGTPFAMPGGEVRIYKCSMSDIGTLPQTAPVQTIATDAIWQLGMVQEGTYLWVAVGDRLHRYSLPVTASSQATVFSSGSAIPLGGNISAFAPLPLPQEVFTAESALDTLKQADIKEEKGNSRGCEAGLPWAGVLLAAAVPFVLRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M929</accession>
    <name>D4M929_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12190"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.459"/>
    <dbReference type="HOGENOM" id="CLU_031290_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-782-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030821">
        <property type="entry name" value="Synergist_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04564">
        <property type="entry name" value="Synergist_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061544" evidence="1">
        <location>
            <begin position="29"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="468" mass="50366" checksum="A25C020E878FA693" modified="2010-05-18" version="1">MHCKAMKRWLSGMLLFALVLAFGAPASAHLLYTVQDNNYTSTSVGKVVGNTTTILANNVGGNWGQVIFPFKRGTADRVAVTLYPNTNPYYPGDEVRIYNPASFNWSSPESTITHARLKNVRALVFMGGHPYGIGYDCTPFAFAYSEDPVRKSAKVARWNHMGGTSYWPDNLYTHLFQYEAPSGYTANGEGLATHDSFVYALFTSHTGNYPNFVYSPNKLVKLNAELGQVGAIDLNGKNTDGGIPGAYCQDSGTLYLTSWGGNQPASSNWHPESRVEKVNLSGMSTQTLVTGQQMRNSDAMWKHHFTAITLHGNTAYVQASTWNQIGPGATPSGEVRVYSCSISSLNTLSQTLPVKTIPITGAWRLGMVQDGTYLWVAAGDSLYRYALPVTASSVATVFGPGGTSLYGNISAFAAIPSLRGVSAAQAAMDEPVQTMAAKDEKDGGSGCDAGFGWLLLLAVVPVALRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M937</accession>
    <name>D4M937_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Fe3+-siderophore transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_12300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12300"/>
    <dbReference type="HOGENOM" id="CLU_013016_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-790-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="328" mass="34781" checksum="4F01D23322B63536" modified="2010-05-18" version="1">MRGRRSALFVLFSLSAAVLVVAPLVGMHALSWRDIWPGEGQGHRIFWELRLPRVCLAWVTGATLGVCGAVFQALFRNPLASPDMLGVSTGAAFGAVLSIRLGLTVSLLSGQSGLSVPAFLGAGVATIVVCAAGSWRRRSTSSLLLSGIAVSFLFSSLTLIVQYTGNYVDTFRMARWTMGSVQAVGFGTLWTTLPALLFILAVAVFCAPELDLFLCGEELAESRGVSVKRLRIGLFVGVSLAVAASVSACGPVGFIGLMGPHICRRLVGPVHRTLVVASALFGGAFLVACDTAARTLWAPAEIPVGVLTSCMGASFFLWLLLRRERHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M959</accession>
    <name>D4M959_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ffh</name>
        <name evidence="10" type="ORF">SY1_12790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12790"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.511"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="447" mass="48697" checksum="27F3DCC3B2B40AEF" modified="2010-05-18" version="1">MFDALREKLEAAFSRLRSRGKLSEADVDAALREIRKSLLEADVDFKVARSLVARIRERALQLDVIESISAAQHIATVVYEELVSLMGDPAPLAIASMPPTVILMVGLQGSGKTTTTVKLARRLQGSHNPLVVACDLRRPAAVDQLRVLAEEARVAFYGPDAGGTDVLEVVRGARQRAADRMNDVILLDTAGRLHLDQELMEELSAIASALPPHEKLLVLDAMMGQEAVNVARAFHERLALTGLILTKLDGDARGGSALAVRAVTDVPVKFAGVGERTDALEVFDSRRMAGRIMGMGDIQGLVEKVQAADAGDAQKIANSLKGKQFTLETLLLQFQQIEKMGPLGKVMEMIPGFSRLKGINVDEADNAAIRRSKAIIQSMTPAERRNPRIIKGSRRRRIALGSGTSVQMVNQLLAQYEQMRKLFKTFSAAGDSKFKLRSLFGRMGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4M964</accession>
    <name>D4M964_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenocysteine synthase</fullName>
            <shortName evidence="5">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">selA</name>
        <name evidence="8" type="ORF">SY1_12870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SelA family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.520"/>
    <dbReference type="HOGENOM" id="CLU_038142_1_0_0"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Se-cys_synth_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="477" mass="51039" checksum="A411EA9585A51836" modified="2010-05-18" version="1">MTVEDIKQKLRAIPGMDVLLAQDWARPWIERAGRETVKRVINGELTAVRRRMLTGQEEDVSPERIREACLGALTEAERPNLRRVVNATGVVIHTNLGRSLMAAEAVRAMERAARGYSNLEYNLAQGVRGQRNVHVEGLVCDLTGAEAALVVNNNAGAVLLCLIALARGREVVVSRGELVEIGGSFRVPDIMEFSGAKLVEVGTTNRTHIEDYRAGLGENTAMLLKVHPSNFRIEGFTAAPERKDLAALAHERGVVFMEDAGSGLLVDGELLGLRGEMDVRTSLQQGVDLITFSGDKMLGGPQIGVIAGRRAVVNGLRKHPILRTLRVDKITLSAFEATLRLYRRGALDDIPTPAMIRIPAETLRERAEGLAAALKGRVAAQVEVVSVEDAVGGGSYPEKPLAGWGVAVSGHPAGGAGRLQALLREGERPVIAGARDDALVLHVRTLQPGDEEVVVNALAALQPEAGPLAGKGECACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M968</accession>
    <name>D4M968_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12960"/>
    <dbReference type="HOGENOM" id="CLU_037423_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-822-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="256" mass="27298" checksum="13B7860733123322" modified="2010-05-18" version="1">MKVRDLLQRVDRVAPFSLAEEWDNVGLMVGDLDAEVSRVGIALDPVGEAVAAAAEQGCQALLCHHPLLFRPLKKLDLNSDPGRAVREAIKRDVAVLAAHTNWDCAEGGVSWELAGRLGLMGITPLDLNTGLGAKGHLPEAEALDRFIERVREAWNLTRLDCYAPANCSILHVALCGGAGAEFWPAAGAWGADIYLTADVKYHELMDATRAGLAVAVADHGEMECVSLPELARRIGAGGGIETVLIDVRGLSAPIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M983</accession>
    <name>D4M983_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13220"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.559"/>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-838-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="324" mass="37429" checksum="3BBADFBD724F53D2" modified="2010-05-18" version="1">MNEIGESSALFYSPSHRSREQIDLDVSQGRVYPLADVLFKFLFGRPERAELFLDLLNALMFPNGERAFTQVAFIDREFSPVRASGRGSRLDLAARLDGELVNLEVQIRREPGYLKRTLYYWSLLYATSLERRGKYLDTVRTISLNLLDFELLPEERECRNSYSIRNDASGRLLCDDLQIVYFELPKDRRERKAGRRPRNRLERWLCYLDGMRGDEMERIAAMEPGIGAALDLEREFFQNRDQRLAYIVNLMEFWDEEDISGRREEAALARGRVEGEAKGRAEGEAKGRADAARNLLRMGLELSKISEATGLSLDEIEALRERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D0</accession>
    <name>D4M9D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">SY1_14060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14060"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.638"/>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="149" mass="16120" checksum="E8D6E4DB5E87B499" modified="2010-05-18" version="1">MRMVVQRVSRAAVSVGGVEAARIGRGVCVLLGVGAEDAQADADWLAEKLVNLRIFEDAEGRMNLSLLDVGGAALLVSQFTLYGDCRKGRRPSFVGAAGAEKGRELYEYFVERVRAQGVETGCGVFQTHMEVDILNDGPVTLFLDTADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E1</accession>
    <name>D4M9E1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="5" type="ORF">SY1_14360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14360"/>
    <dbReference type="HOGENOM" id="CLU_145918_3_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="87" mass="9643" checksum="2474C3AE06995484" modified="2010-05-18" version="1">MPFAENLARLDEIAKRLESEPMSMDEALAVFEEGVALVKKSEKLLQRAERKVTILTEEGEALFEAAQPSGVEEEGEDEGENDGEFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E6</accession>
    <name>D4M9E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_14510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.689"/>
    <dbReference type="HOGENOM" id="CLU_1330330_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-902-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="2">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="206" mass="21591" checksum="86A1C8EA9CC2A439" modified="2010-05-18" version="1">MRAGDGASARSALIVAGGTGGHIFPALVFGRWLEAHCGAAVSYLSGSRPLEAEIYAAAGVTPFRLSLEGSPLGVRSPLKVLRRSLALVSAFGEVSRRLAEVRPTTAFLFGGYVSFAPLLLCRLRGIPVVFHEQNAVAGRVTRLASRLGAVIASGWEECQGRSRPSRSDGGSRQNAAPSAPRGGRASAWPVAEGGLPRRRGHQRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F1</accession>
    <name>D4M9F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted dehydrogenases and related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14610"/>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-907-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="322" mass="35594" checksum="1700AC0EFF3FB181" modified="2010-05-18" version="1">MESIKRFGVIGVGHLGQHHARVYTELLDARLVGVADNDPERARSIGAHLGVPAYGSLEELIDRQAPDAVSIVVPTSLHYEIAKRAMEAGLHVLIEKPVTTRPEEAEDLLRLAAEKDLVLQVGHIERFNSAIRYISQTAHKPIYLESKRIGPFSPRINDVGVVLDLMIHDIDIILSLVPSPIARIAAAGACVSTEHEDIADAQITFENGVVAHILVSRVSEKKLRQLEIMERQRQITVNYETQTVQINRCVSSSDGQMEILESPIFPKNEPLKLELAHFVSCVRDRRQPLVGIRDGKRALEVAIEVLRQIHDGPAASGERATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I5</accession>
    <name>D4M9I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15100"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.768"/>
    <dbReference type="HOGENOM" id="CLU_1530378_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-942-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="175" mass="19541" checksum="A46A1520DFFE4FCA" modified="2010-05-18" version="1">MNSMKTLRWTLYLTGVILILLGLWSLFYPLEALLSLAIYLGIGLCLSGLNYLLPCFSLRGEALYPRWFLFLGIMDLIVGVLMLTRIGLTAFMIPMVVAAWLCWIGLVRLVTCIRLRSLHLRGWWIMLLSSLALIACSCAMFLSPLVGWLSVVAILSSTLIAAGALNILEGRMIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I8</accession>
    <name>D4M9I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15130"/>
    <dbReference type="HOGENOM" id="CLU_1545380_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-945-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061035" evidence="1">
        <location>
            <begin position="28"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="173" mass="18123" checksum="E8D45679577A0577" modified="2010-05-18" version="1">MALKHWRSALALVLGLVLCLTAGTAHAVLPKGSIAVLSKSASAQEAAQVASVFTRQLLAKGYKVVDPKKLDAIRRSKAAALALDGNVDAIMKLSRQYGFSTLITAQSEAGRPVLNEFQLYTGTSSIAVMVTASNGSQIYADTVAGKQVGYTPSEAQQKSLEAAAALAVKRMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9J7</accession>
    <name>D4M9J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized Fe-S center protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_15300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15300"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.788"/>
    <dbReference type="HOGENOM" id="CLU_046240_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-954-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="370" mass="40022" checksum="2484EA50D7D45B60" modified="2010-05-18" version="1">MNASKVFFTDMHTTPDENLLQKLKRLMRATGFEALPFKGGRFAAVKVHFGEPGNLAFLRPNYARVVCDYVVQLGGRPFVTDCNTLYVGGRRNALDHLDSAYANGYNPFATGVHTIIADGLRGLDERLVPLEGCTYVKEAKIGSAIMDADVIISLSHFKGHELTGFGGALKNLGMGCGSRAGKMEMHSAGKPHVEQEKCICCGRCVRICAHDAPHVTPGRGATIDHDRCVGCGRCIGACPVDAVAPDYDEAFDITNCKMAEYTKAVIQGRPHFHISLVVDVSPFCDCHAENDIPIVPDVGLFASLDPVALDRACADAVNRQPAVEGSLLAKNGHAHHDHFTDVSPDTHWISALEHGEKIGIGTMNYELIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9J9</accession>
    <name>D4M9J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-2,6-bisphosphatase</fullName>
            <ecNumber evidence="1">5.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15330"/>
    <dbReference type="HOGENOM" id="CLU_033323_8_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-956-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="214" mass="23539" checksum="91F29DBD4F8A448C" modified="2010-05-18" version="1">MRLFIVRHGETAWNREGRFQGQLDVPLNEAGMLQADRVAERFRGYPLAAVLASPLSRARVTGERIFDAADCDAFVVDDGFQEINHGAWEGVTTDEVARRDGELLRLWRTDPQRVTMPGPGGESLADVGRRAVEALERVALGKYEGDVLLATHDAVGKVLICHYIGLPLTSYWRIRIPNCGVSCLDFNGDGPQLSLLGDVSHLGCGFESFLSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N5</accession>
    <name>D4M9N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15940"/>
    <dbReference type="HOGENOM" id="CLU_2665782_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-992-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="75" mass="8187" checksum="70DEB788F3A97440" modified="2010-05-18" version="1">MERLIETMRGIVGALNAHGLGLGDGVSLVDRLARLETRLDHLEKTLNNTQKILVGLAISVLTLLIKMAIEGLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q5</accession>
    <name>D4M9Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted divalent heavy-metal cations transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_16220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16220"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.892"/>
    <dbReference type="HOGENOM" id="CLU_015114_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1012-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="260" mass="27435" checksum="68814681F876C065" modified="2010-05-18" version="1">MNLQVFQGILIPFLGTSLGAACVFFMKGELNDTIRRALTGFAAGVMTAASIWSLLIPAIEQSEPLGAFAFFPAAVGYWAGTLFLLLLDRVVPHLHMDAQEAEGPKTRLPRTTMLSLAVTLHNVPEGMAVGIVYAGLLSGVEEITAGGAMALALGIAIQNFPEGAIISMPLHAEGESRRRACVEGILSGAVEPIAAVLMLWAAEVFTPLMPYFLSFAAGAMFYVVVEELIPEFSSGKHSDVGGLMFAAGFTLMMALDVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q6</accession>
    <name>D4M9Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16240"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.895"/>
    <dbReference type="HOGENOM" id="CLU_791684_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1013-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="350" mass="39309" checksum="2FF137B63A6A0040" modified="2010-05-18" version="1">MDRAERDEAGSMNREVKATVFSDLFKIKKYLFQLYRTLHPEDTTTVEDDLTDVSINNVLVDDIYNDLGFMVSDRLVVLVEAQSTWTENVLIRGAMYLVQTWRNHFARTGADLYHAPRAALPRPEFYVLYTGERVARPEVLSLSEEFFCGEPFAIEVRARMLYGEGTGDVISQYASFCRVLGGQVKLYGRTRRTIRETIRICKERDVLKEYLEDREAEVMDIMTMLFDQETATRNYVDRVRREAAERSFARGNAEGLAEGLARGNAEGLAEGLARGNAEGLAEGLARGNAEGLAKGLAKGNVQGFVNACRDFGVSRNEALARVARRFNLTAEDARSEVERCWEAKGAAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V1</accession>
    <name>D4M9V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_17170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17170"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.984"/>
    <dbReference type="HOGENOM" id="CLU_305386_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1058-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019286">
        <property type="entry name" value="DUF2339_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38434">
        <property type="entry name" value="PTHR38434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10101">
        <property type="entry name" value="DUF2339"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="887"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="940"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="971" mass="106054" checksum="7FDBE58DBB9D7918" modified="2010-05-18" version="1">MLVLLVFAIFWLILSPLLILGKVGDATERLSRRITALEKAIDAMRQGPIPREASKEQPSVTPLSEVQPSADLLSEELPLAPPLPEAPPPVELPVGEAPIDLDLPKVPEVSLEAPEPSESLRETPEEPTVEELPVAAAAAFHPDNPDGPNDDVSLSRQPGSVAAAWSRLITWLIAEGNIWVCTGVLLFLVGFGLLFSYAVHLGLLTLEMRLAGAAVTGLLMVAFGFRMRLRRRAYALVLQGGGMGVLYLVVLAAAKLHSASTNVPILPEGPAVGAMIFLSVVTVVLALVQDYEPLALFAVLGGFAAPHLLQVGARSPVTLFSICTLLNFEILAIAFRRRWRLLNRMGFLLTAGIALFWGQRNWRPDLFSAVEPFLLAFLATYTLITLRFAMRRAGGESPDAAEASRYDADMPLTVLVPFVFFFLQSHAAGHLAYGTASTCLGLGVWYLILGVWLRQRGERYQPVVWRLFAALSILFSNLVLPYAFERVLSSAVWAAEGAFLVVAACRYGSLKALLGGIFLQVGALCLYAPELARIDLTVDSVLSPILASGVLFAAALWCSGFWITRFRLRGEDLPHGTRWERQASEFLRSNVDSACVVLSWVLTGAGALWWWGTMGDQVPRIGLPWLSAFPVVCLTALAACWASLRLDWRAAQLLLFGPLIAGILWVFETLPFVLRPVTLDFFGIGRSLTASAIVYAATIGPSLRLLYQTKAGFRGIEIFHFAAILVGLRLADMALGRWGLRWGGDWAQLLSLLPLVALLLHVSRARERSAFAGSPKSLAFATALPLLLQLPAFVDSFKWKGTAVGGLFVPLLNPLELWQATFILSCVLWFRCSFVKDARPSHPLRQGFFGFLFVWVNQVAARAAWWYSDEAFSSIWMALRTSHCQGIIAILWGVLGLAGILQGKRLRSRSLWRAGAGLLAADMVKLLIVDLSRSATLTRIFAFLVLGGLFLLIGWAAPLPPRETAADRGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V3</accession>
    <name>D4M9V3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">SY1_17200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17200"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.987"/>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="116"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="304"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="219"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="447" mass="51289" checksum="586B0D3E1F7F4900" modified="2010-05-18" version="1">MTENKNVRVRFAPSPTGALHIGGGHTALFNWLWARHTGGRFILRVEDTDRVRSTKEYEETIMSGMRWLGLDWDEGPDRGGDYGPYRQSERLDLYRQYARQLLDEGRAYRDGEAIVFKVEPGQDLSFDDCVYGRIESMSDGLKEKDSEKLKDIVLIKSDGMPTYNYAVVVDDHLMAITHVIRGEDHISNTPKQILIYRALGWETPRFAHLPMILGKDKKKLSKRLGATSVYEYRDLGYMPDSVFNFLALLGWFAGDDHEIFTRQEAADLFELSRVTRKPAVLDVDKLNFINQEHLKRLDPMTRLAMVRPFWEAMGLPVKEHGDEWLAEALTLMEGRGRTAREMAEFTDYFLSFEPVKARWDGSALTADERGLLKEFFAAMTSLSDWTPAGLEAFARSWTAERNVKMKDYAMPLRWALTGMKVSPGIFDVAVHLGRDEVKRRLSHYGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V6</accession>
    <name>D4M9V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17230"/>
    <dbReference type="HOGENOM" id="CLU_3118145_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1063-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="50" mass="5655" checksum="4195458C66345D6F" modified="2010-05-18" version="1">MNFREALKDTPNLMSLDCFQQRSLRCVSKGSLAVNCAVSFPFTFIMPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V8</accession>
    <name>D4M9V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17250"/>
    <dbReference type="HOGENOM" id="CLU_1793670_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1065-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="144" mass="16319" checksum="F46BEA72F574983A" modified="2010-05-18" version="1">MEAQVLERDTERLQEALDSLPFLEPVVKDTLKEFVLRLKEAEGENLLRVVLFGSMARGDFDEESDTDVFVLLKEGTDIQLTERVCNIADDAATSISDCYVYISPFIETADSIAEEYKGISRWRFEPVFDAIREEGVVLFESGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W8</accession>
    <name>D4M9W8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="4" type="ORF">SY1_17390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1004"/>
    <dbReference type="HOGENOM" id="CLU_071472_0_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1076-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="120"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="178" mass="20369" checksum="958C6A1958987B06" modified="2010-05-18" version="1">MEVRFVQRGTEIDSKLRDYMDSKMSKLEKFFGKIQNCQIVVSHHKGNFNIETTANANGVILRAEENATEPRRAFDLSLKNLERRIKRYNSYLKDKGQFKGGADFSFNLEEGQEPVASDVPVIEKVKKVPVQPMSPEEAAMQMELVGHAFFMFQNAETGDVNVVYKRRSSDYGLLEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X6</accession>
    <name>D4M9X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1027"/>
    <dbReference type="HOGENOM" id="CLU_022936_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1084-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="502" mass="52039" checksum="3C43A9F748901A1E" modified="2010-05-18" version="1">MSTWELLQSGFGVLMDPYTFMMMAFAIVVGTLFGALPGVSATMAVALGLPFTYSMKPVPAIVFLVAVYCSSITGGSITAILFKIPGVPSSAPTTFDGYPMAQRGEAGKALGIALGSSAIGGLVSAFCMLLLSPQLTQAALSFSPADIFAITFMGLSILTCLDSRNILRTVISGLLGLLLACVGQDTMYAVQRMTFGSTQLIAGLEMIPVLIGIFAVTEVLKQTGTDRRLKAEQGVGGGSVSTKMPSVSEWWGIKWLLARCSVIGTIIGILPGAGATIASFLCYSTETKLSKYPEKFGTGIIDGIAASETANNAATGGSMVPLLSLGIPGGNAAAVMMSALVLKGVQLGPLLLKNQPEYLSATFASMFVTNILMVVVAIFIARIFAKVLAVPYSYLGPIIIMLALIGSYATNMSIADVKIMAVAGIAGLAFSACRFNSAALILGLVLGTICEGNFSRAFTLSHANLAAMFARPVAGTLMAVSVVLLLYPVVAPLFKKGCKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z4</accession>
    <name>D4M9Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin biosynthesis protein CbiK, Co2+ chelatase</fullName>
            <ecNumber evidence="4">4.99.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_17900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.99.1.3" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17900"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1058"/>
    <dbReference type="HOGENOM" id="CLU_036584_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1102-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016852">
        <property type="term" value="F:sirohydrochlorin cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010388">
        <property type="entry name" value="Anaerobic_Co-chelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06180">
        <property type="entry name" value="CbiK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033579">
        <property type="entry name" value="Anaer_Co_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061227" evidence="3">
        <location>
            <begin position="23"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="296" mass="32634" checksum="01F6769A1F19FB34" modified="2010-05-18" version="1">MNKFVCVMLVAAALLSASPAWSAHGDAKPDKMGILVSSFGTSMPEARPAIDNLVEAAKKAFPDAEVRLAFTSNIIRRKIARERNEVVPTPVQALAAMNDEGFTHVYVMPTHIIPGEEYDEMQNVVDAFASLKGKYGFKKIALGAPCLNGVEDCDKMAKLLMTRFEKQLKDKGTAIVLMGHGTPEHIAHAMYSQLQFSLDKVAYGRFFLGTVEAEPKVEDVIRALKRHKDIRKLVISPLMIVAGDHANNDLAGADDEESWLNVLKKAGYKDVTPYLVGLGQDENIAKSFVERIREMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA07</accession>
    <name>D4MA07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted branched-chain amino acid permeases (Azaleucine resistance)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18420"/>
    <dbReference type="HOGENOM" id="CLU_144816_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1115-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003203">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="112" mass="12005" checksum="6581C64D1983A2F3" modified="2010-05-18" version="1">MTELFCGPHAHDALIVLVSGAVTLALRFLPFLTFGRRTPAIVAYLGRVLPGAIMPMLAVYCLRNVNLTAAPYGAPEFLACAVAALLHVRLRSLLLSVLCGTACYMLLVQTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA30</accession>
    <name>D4MA30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Restriction endonuclease BglII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_18750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32617">
        <property type="entry name" value="SbaSGP1ORFAP"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18750"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1136"/>
    <dbReference type="HOGENOM" id="CLU_1480384_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1138-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.91.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011338">
        <property type="entry name" value="BamHI/BglII/BstY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015278">
        <property type="entry name" value="BglII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09195">
        <property type="entry name" value="Endonuc-BglII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="211" mass="24511" checksum="18B9F75B39A22244" modified="2010-05-18" version="1">MKIAQVYSHLNGLEFLLVHRPALWDEVKAAVQNVDASLAFNKVSREKTMTGRTLFAPKELNRLFKAEFLSKGWRETRIDYFVNEDLETTRDTVHIRDKDRQRQAITEKGFTAYSTYNQVDFVKDRVAVEVQFGKYFSVQYDLHVKHTFFYERGDIDAGIEIIPMHSLMSQMSSGLAWYENELTNIVREGRSNPSVPIVLVGIEPDERRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA47</accession>
    <name>D4MA47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_19030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19030"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1164"/>
    <dbReference type="HOGENOM" id="CLU_075023_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1155-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="321" mass="36047" checksum="01A59AC1328EC48B" modified="2010-05-18" version="1">MVRMLVNTPYDDVFRTLLNDCSSLIIPIVNEIFHESYSGDEAVEFYSNEHFINGQDGKERERITDSCFGIRGRSLKKYHIECQSTSDDTMLVRMFEYDAQIALDAGEVNDGVLTVRFPASAILYLRCRATTPDVLTVRIELPGGRSAAYDIPAMKAQRYTPEEIFSKGLLFLIPFRIFAHEGRFGRYERDEGLLRDFLSEYAGIRDRLEGLAESGQLTEYVKRTLEEMSGKVLEHIARGHEKVREGVKSIMGGRVLEYEAKTILREGIALGEARGLARGEAKGIASTARRMLMRGVPLEQVVDFTGLSLGEVEALRGESGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA53</accession>
    <name>D4MA53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_19100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19100"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1177"/>
    <dbReference type="HOGENOM" id="CLU_247380_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1161-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="8">
        <location>
            <begin position="762"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1396"/>
            <end position="1420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1528" mass="170297" checksum="2D75D696234A622A" modified="2010-05-18" version="1">MTEGRRLKVPEWASLSRSLERSLGDFLPCGISVAVEERALERPQEFRMLCLTLKGQRLRKLAAEFGEDGSLTLHWLLPSEPHVFVDLTDGATDTKWASAHIFTLKGFSRTEGGEGEENSPSAYQTDRSRLKLAPDLDEGRVSQLWWHDAERLWGQFAHSVEADKVNLKAFVRLEAGLNALWVSSRKRHRLLTKIGSPHRENPLLRLEGQRQVCIGLWGVESHGRLRLPHESHRGRLCPFQTPESKRTGLDLQLAAGAEVKNDGSIKPNDDYLFSIAVGMIPYPLHTDGPRLMMGGKNMKQAEIEIEGAEPPIVPGYLEGQRARFIPALKGSLDSNGRLSPPIGLNALTLVMPFEGYTYEDGLVVSESLARHFFIRNGTHTIRKTCERWIREADFNVPDIASAIRDSTPVPEPRYLYGAPLPIPAFNFQERDRHGSLKPCPLPRVLYDHHAPGTLDKGGFHVDVRLSRPSGTENSRGIRVTLDLTWTFRVERPLGLGDKLTGRNGNKGVVTRILADEAMPKVRIGGREYRAELIISPSSIMGRKNLGQLWEMTHSVLLKSAPKGIPDDDELEGKQKENLSELMRRAGADEWGAFPVSIPTENGHREFRAFAGWQYFCRLHHHALKKLQARGAEGPIQEASGQPAVCGSRTGQRLGEMENWSFLSHGADDVLFKMRAHFTGDFARTRDLMQRIYRSLGLTLDAGRDVLRVSRAPEAASAKQDKTEPESLRAFLNRTRDDGNADDAGKLVCYKDPDSKGSPHSMEAFLDQQIEQLKNAQLKNTEDPKARKRLKSLLDKAKKLKSLLGSQGNLYVDPKLLRLFPGLRTALSEILHATGKEKQLMAFLRYREQLVALLSGKEGVPRRHLLGRRYNHSARAVIVPCPDLALHEVRLPLMMLTELLDGYEDERAGSLFSEPPFKVRSYVNDPLCREWSDEEAKRCDQKLCTEYELWAFLVRQPSLHRHSLQAFRVRCWNEPVIGLPPFVTAGFNADFDGDTMAVFLPHPSSGSLEKFSLPNDPGLVGTGAPALASGLDLALGWWNLDKADRDKWLAQAGLDDPTGQRPQKLEDFLPVLLRHTASRSWAERSALLGRLQHAVCSASTGAATLTPLEFERLAACLDQLLPCKEGKKEEDAEAAIAAFFRERPDLGLARMVASGAKGKVRDVRHMTWAIGEITKIKGTPDKPYIRGNFWRGLTEDEMFLYSYPSRDSMAQKKLAVAEAGYLSRQFAEGLFELRVQREDCGTAKGLEVGYSRMEQKECLTLSLDGETFTLPTLGKLERDLERVAWGRTLAGQTARSLSKDDLKAVLAFWKEGLDISDDELKEHLLANKNRLVLRSPLFCACPPDEGVCALCCGADLSQKPLDIPHPVEIGAFVGLTAAQAIGERGTQLAMKRFHDVSGGPQGNKIAAPQKDNKSADRKKDNDNKIAGLRENFIKGPETHDIKKRLGKMLDVLAKGDSDAFEELPQALIHYELALRQSLARGLDAEASDSEGRYLSALAHERIEPLLGGASFTDDFKTIKSRLLWGGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA93</accession>
    <name>D4MA93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_19680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19680"/>
    <dbReference type="HOGENOM" id="CLU_3007712_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1202-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="56" mass="6107" checksum="32604B41CFE50914" modified="2010-05-18" version="1">MACIRCVLPSPTPPQMNRGLKRSFTGASVETKLSATARLEACARRFDLPTTKLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB5</accession>
    <name>D4MAB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type multidrug transport system, ATPase and permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_20190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20190"/>
    <dbReference type="HOGENOM" id="CLU_1406957_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1223-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="193" mass="21637" checksum="89A90E61D84E51D7" modified="2010-05-18" version="1">MLASSGLNVLPPWLFKSVVDDVLISRSVLSLNLICLAVVAIFALKAVTSYWQQYLMNEVGQSVVMDVRVALYDHMQHMALQRIDASRVGELMSRITGDVATLQSLVTNTFVDLAFNAVTFAGMFAFILYINWRLTLLIVLVLPVVAWLLSFAARRLRRAGHRVQERLADITAIAQEAFSAIRWCAPSPRRNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC5</accession>
    <name>D4MAC5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiA</name>
        <name evidence="6" type="ORF">SY1_20430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20430"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1305"/>
    <dbReference type="HOGENOM" id="CLU_022752_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1233-MON"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="247"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="461" mass="48721" checksum="1B9AAD41EB13ECBC" modified="2010-05-18" version="1">MTTAQPRLLVAAAASGSGKTTIVCGLLAALYRRGLRVVGYKVGPDYIDPGFHRAAGHCEVLSLDTWLTPPAVMKGLFARTSLGADVAVAEGVMGLYDGGRGGVSSSAEIAKLLGLPVVLVVDARSMGQSAAAVALGFREYDRSVDLHGVILNRLGSASHRDTIAEALERVGIPLLGAVMRDEALALPERHLGLVPEAETHDAAQLDRIREAVERGVDVDALLAIARSAPPLPLPPEGTRSRAAKDVRIAVAQDLAFSFYYPDSLSALEDRGAELIPFSPMQDEALPEADGVILGGGFPERFAGELAANASMRRSVARAAERGVPILAECGGMMYLCRSITDMEGAAFEMAGVLPASCRMQHRLEAVGYVEARALRDTVLGPAGTLLRGHEFHFSAMTPEAEDFPWAFRVERKRTGAAHSGGYARGNVLASYLHLNLAGLPDAADSFLARCRAFRSASAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE6</accession>
    <name>D4MAE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase 24 kD subunit</fullName>
            <ecNumber evidence="7">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_20820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20820"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1341"/>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1254-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="163" mass="17894" checksum="71BAFE5417EC8B9A" modified="2010-05-18" version="1">MRYTDVDVSRIRDILLRHTADQTNLIPIMQGVQALYNYLPRPALEMIADYLHVSISKVYGVATFYENFSLNAKGKHIIRCCDGTACHVRKGATILGAIRKELGLTAAQSTTDDMLFTVEIVSCLGACGLGPVVVVDDEVHPTMTVDKARELLESIRGKEARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF3</accession>
    <name>D4MAF3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaC</name>
        <name evidence="7" type="ORF">SY1_20910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20910"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1350"/>
    <dbReference type="HOGENOM" id="CLU_074693_1_1_0"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="168" mass="18093" checksum="079BFB3D6D70F27C" modified="2010-05-18" version="1">MVDANEDFTHFDEQGRARMVNVGGKDVSERRAVAAGRILVNERTFELIKSGGVKKGDVLTVAQTAGIMAAKRAPDIIPMCHPLLLNGVDLSLTLDKTRLSVEVRAEISCEGRTGVEMEALTAVSVALLTVYDMCKAVQRDMTITDVRLLSKSGGVHGDFTREEGACGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG1</accession>
    <name>D4MAG1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_21010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21010"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1360"/>
    <dbReference type="HOGENOM" id="CLU_001600_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1269-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1154" mass="128140" checksum="87456A7F88CE6833" modified="2010-05-18" version="1">MTRPFVHLHVHTEYSLLDGAIRTKQLAAKVADWSVPAVAMTDHGVMYGAVEFYENCRAAGVKPILGCEIYVDPDGHRSREKKGKNNHLILLAENEEGYRNLVKLVSIANTDGFYYKPRIDHDLLASCARGIIASSACLAGEVPQLVLQGREDEAAKRALLYQDIMGKGNYFLEIMSNTLPEQAVVNKALIRIAKDTGIPLIATSDAHYLNAEDYEWHKILLRINTHADDTDDAFGFSVNDFYLRSPEEMDAIFGAEVPEALDNTVAIAERCGVEMKLKTGHYMLPSLELQEGMTLDSHLEDEARAGLRMRLNADTPPAEYAERLEYELNVITRMGFSAYFLIVAGIIQAAKERGIPIGPGRGSAAGSLVAWSLRITELDPLKYNLLFERFLNPERISMPDIDTDVSDRGREQLLKHIVERYGSDRVSQIITFGRMKSRQAVKDVGRAVGMEYALMDRVAKLIPADARSIREALERTPELTELAEEDPRIKNVLRTAEHIEGLARHASQHAAGVVITPVPITDLVPIRRIKSTAPSAPDGELDVTQTVTQFTMEPVEKLGLVKMDFLGLQTLSILEEAVENIRLNGKNPPDLLSLPMDDPATYKLLQEADTMGVFQLESDGIRGMLRKLRIDCFDDLVAALAMYRPGPLDSGMVDQYIKCKHGQAKLEYPHPLLEDVLKDTYGVILYQEQVMQSASVLAGYTLGEADLLRRAMGKKKVEVMQEQRAKFLDGARQKGIDEKTASGIFDLIEKFAGYGFNKSHSAAYALVSYQTAYLKANYKAEFMASYLSSQMKSKKDVLGHYVREVRQSGISVLPPDVNSSMESFTAVGDVIRFGLGAVLRVGHNAVEAIVKAREEGPFKSLWDFLRRVDLHDMNRAMIENLIKAGAFDEITPNRARLVAALPDFILAAQKMAAGGDQLSLFDAIGDDSGSDPEPDLPDVEEYGIYDKLDYEKEVTGLYISGHPFDSCEAQVRKYANCSIADLPLWRGKTAPKVGGLILSVSEKTTKKGDLMGVLLLEDSESSVSMVAFPRTWAKVKESARVGVPCVAEGKMDDREQLLLDKLTPLSDFSEQDPQIVRIRLRVNLVPQFDVKNFARALRGCRGASPILLELRDDHDACVLYLNDFRVDARSPERLHERLLEAVPAEALEVCLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG9</accession>
    <name>D4MAG9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mntP</name>
        <name evidence="9" type="ORF">SY1_21130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21130"/>
    <dbReference type="HOGENOM" id="CLU_096410_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="200" mass="20798" checksum="E80341A973BA2350" modified="2010-05-18" version="1">MSWAAVVSGCSLAMDAFAMSICVGACTVGSPWRPASRLGLACGTFQFFMPLLGWKLGMASARWFSFWDHWLAFGLLAFVGGGMVCDFLRGGEEECRDVTRSLRLLLTVALATSIDALAVGAGFGLTRLPVMPLAAVAGGVTAGACAAGTWLGRTAGAGLGRKMELLGGVLLILIGLNILATHLMEEWRMGTASVLPPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ2</accession>
    <name>D4MAJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Large extracellular alpha-helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_21630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1416"/>
    <dbReference type="HOGENOM" id="CLU_000965_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1301-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021868">
        <property type="entry name" value="Alpha_2_Macroglob_MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041203">
        <property type="entry name" value="Bact_A2M_MG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041462">
        <property type="entry name" value="Bact_A2M_MG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041246">
        <property type="entry name" value="Bact_MG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17973">
        <property type="entry name" value="bMG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11974">
        <property type="entry name" value="bMG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17972">
        <property type="entry name" value="bMG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17962">
        <property type="entry name" value="bMG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061241" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="domain" description="A2M_N_2" evidence="4">
        <location>
            <begin position="907"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="A2M" evidence="5">
        <location>
            <begin position="1119"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1779" mass="194688" checksum="EAA2EBE8AFBF1066" modified="2010-05-18" version="1">MRFQKWLFPTILAALCLCLGAAPGRAALPAGVQSFAPTGRVSDNVSFRLVFKNAVAAKKDVGRAMGVEEFPFEVTPAIQAEGKWQNETTFTARLLAPLRMGTSYTARLREGLTDRKGRHIPAGSFSFQTDALTPTAVKAIMGRDDARLVIAFNMPVAPAVLQGFLQIVNEQGQKVPFTLQGTAPNRSVQVRVPLGQSLSRQTLTVRIAAGLTSGEGDLGLAQNFTSRVVLEPKLTVEGVRGDEGAIQASFNFPIDPESVRDFVAVEPPVDFRLDSNWSGNALQIRGDFKPRSRFVVTLRRGLPSKEGGLALKEDFKQAVIMPDLEPSISIPTSGTYLTAMGGGLIPLELVNVKKLQVNLWRLYENNIPYVIRGDYNSFSKDLARRTYSREFKLDLPLNERVRRSLAVDELASGDRGLFLLSVRDPDAEYWDEEDQMLSLSDLGAVARVWEDGLMLWVNTLSGTQPVADAEVRIYSGANQVIAQGKTDAEGIFSFDRQEPWGTDAGEQPRLAVISSGRDLTYVQLTRSLLSQETFDTAGRPWLREGYDAILFAPRDIYRTGEEVPFKAVVRGADLSTPAPFPVLFTVRDPLGRRTEQQTVTLSDMGSALFTLKLPSNALTGLWSAAISVPGREESPMASMNFHVEDFAPPRIEVKMSTDSKTLTHGDDFQAAITARWLFGADGAGLRYKTFWSAKDSPFTPTQDRWKGYTFGDSSRKFEGARNDMDEGQLDASGRASSTLTLDANWEAASTIAVTLRTEVMEDGGRWVSDSITLPYFPAPWLLGIAATEEQMAVNRDLTFRIAAIDPQEEPTDPGSLTASLYRVRWNYNMVEVDGYRRWQSSEELSLVDEKSVTLKDGLGSVSFRPGEWGTYLVRVTDANDNARAAMRFYASDARYADRGGSPILDRVGVSMDREFYRVGDTAKVTLTAPFEGLLLFSVEGARPISRQVRRVDGPDVTVEVPVTQDMVPNGWITAWLVRPVSEEDASAWGTHRAVGVARLKADLTPYKLDVTMEAADRVEPASTLPVSLTLKDAEGKPVQGDVALALVDDAVLGLTRYKTPDLLEHFWGLKKLNSEGYDLYDLLIPVESRATETLHPAGGAAMAALAGAGANVQRFNILSLFQGLLSADAEGRVKADLDVPEFSGRGRLFAVVASQNRFGMAEQPVQIARSVVTEVNLPRFAAPGDVFVAPLSVFNASTEVRDVTLSISAEGGLKVAESQKTLRVEPGAQARWETEVSALEPGVASWDVVTSWTEGGGQKEYRQTITLPIRSPWPVVSRSGSGVFESGTTPIDIPTEDFAGKVTGTLSLADTPMVDLTRAVPYLLNYPYGCLEQTLSASWPFLVLPDAVSALDPLLVNDQLVRDRVETAMAKLQSMQLYDGSFETWPGTGHPYAWGSVYAAHFLVEAQQAGVDCPKDMLAGAMNWLHQFLASMPAEDYPTAETDDFTAKAYAAYVLARNGEKPLGWIEYLRENRENMWPSGRIWLAGAQAVIDGRGDALRELAPVDSKLPQAARWRTLESDVRNTAQLLSLWMEVEPQATEAVALAASLVKWGQENRWYSTQDNAAALMALARYNLKVGTEKANLQGTLTDGTKDLLTYRSGSASSIATSELPARVTLNVQGTGRGYYTWNLMGTPRSQPKAEKRGIDVECAWYDEKGGALDLAQPIPQGTRMQAVLTLKPSLPVSGLAVSCLLPAGLELENPRLDPGLDDVAGSYGVVGDVRDDRLLLFFDRLERERTYSFKVRAVTRGTFVIPPISATGMYDPAVHFTGRGQSDLTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK3</accession>
    <name>D4MAK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_21800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21800"/>
    <dbReference type="HOGENOM" id="CLU_899061_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1312-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="307" mass="34706" checksum="A6424C76B2BF4732" modified="2010-05-18" version="1">MTRRGDEFLSRLIYYVLFLLILLAAIRIYFSWLDSYRLSHPQIIEAFAAGYVEEQPLEGILLWDEQPVFAPQDGVFTYPSPLPRRVAKGEMLAALDGVAIRAPYPAYFYPALDGQEGHWFYSKLWPDFAPFPFFRPAVLLENGTQLRKGAPIGKLVPQPQTLRCIAYLDGTPSLLRSLRMRKAAIRIKTEPEGKERKAEVVSFKTMGQKVKVCLRLPFFPPEALRSRSFSARVVAGDQQGVMVPDSTVITKDGRNVIFLLQGNRVLSRDVEGFPAGMGHFFIVRGVMPGNKLILDADTIQESIVRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL4</accession>
    <name>D4MAL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_21970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21970"/>
    <dbReference type="HOGENOM" id="CLU_1576194_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1323-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="169" mass="18822" checksum="884FA8F5FF4AAB5F" modified="2010-05-18" version="1">MCPHPSRSVLRAALRTGMGLALCAALCLSLCRPLWASGNVERALALLEKFTPGMTYEQTSALLDAAAEANAVGGDKKLLRRAWLHGEFGVEIYFLEERAYRIDVLSHFAREQDVSKALDEVLRLGQGRYGSAPRFDLNLGEYYWIAGAYRLSFCKAGPREVRLSRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL7</accession>
    <name>D4MAL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Competence protein ComEA helix-hairpin-helix repeat region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_22050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22050"/>
    <dbReference type="HOGENOM" id="CLU_052011_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1326-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="230" mass="25113" checksum="2C3D5E4EAE013CC1" modified="2010-05-18" version="1">MWRELWNRYRVQTISVMGFVLFAVVGATAMLLPSVKERLERQGAEAQPARVQPRAPSAGQPEAERQSAQEAAPQAEWYLYITGSVRKPGVYKLPANSRLFHLVDAAGGFDGFADRVAVNLAEPLTDGLHVHVPRKGERAAEAAPPIVPVVRPNVVLHVPPAPRRSGRIDINRASAAELEALRGIGPTLARRIVEYRQEHGPFTSVEDLVRVRGIGATKLKGLMEQASVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAM2</accession>
    <name>D4MAM2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gatB</name>
        <name evidence="12" type="ORF">SY1_22130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22130"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1463"/>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="342"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="496" mass="54966" checksum="519C25DD85BD3221" modified="2010-05-18" version="1">MSGKDENMNSELTFTPVIGIEIHIQLKTDTKIFCGCSTDTGADPNTNICPICMGLPGALPRLNAQVVQQGMLAGLALHCTIQPQSLFFRKSYFYPDLPKGYQTSQCDLPIVTTGYIEVHDDEGKLKRIRVHHLHLEEDVGRLHHSAADGRLEGAATSYVDYNRSGLPLAEIVSEPDVSSAREAVEYVTTLRRRVRYSGASDVDLEKGMMRFDANVSMKCSDGRWGKKVEVKNMNSFHALERAIEYEIKRQKKVLLQGGQVLQETRHWNDAKGVTTASRSKEFYRKFIVDPDLPPLVVSKEWADEVTAMMPEMPDVKAERYVEAMHIPPEIADVLTDSRDLAEYFEACVAAGAAPLRAANWVRTEVLRTLNERQIGLGDLRIAPRALAELVQRVEDGRFSTTQAKDVFDRMAETGTTVDDAAKACGITEGGVTGDALTEMIRAVLEANRDVVDVIRSGKDTKGKKMKFLQGLVMKEAKGQANPAELPDRIAKLLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN1</accession>
    <name>D4MAN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22260"/>
    <dbReference type="HOGENOM" id="CLU_3168418_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1340-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="47" mass="5765" checksum="1555F6D8C54C8632" modified="2010-05-18" version="1">MEGVRISQTRWPVELYEWIRERAHERRQSINRTVVELAERVREEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN9</accession>
    <name>D4MAN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22380"/>
    <dbReference type="HOGENOM" id="CLU_3416786_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1350-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="26" mass="2673" checksum="71DDEF0CF96DB68E" modified="2010-05-18" version="1">MSDNVNGGAGGQAHKKRLTEMSHCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAP2</accession>
    <name>D4MAP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dissimilatory sulfite reductase (Desulfoviridin), alpha and beta subunits</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_22420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1487"/>
    <dbReference type="HOGENOM" id="CLU_139698_5_6_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1353-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="57" mass="5598" checksum="9441E6363A8460D8" modified="2010-05-18" version="1">MAKAKVDSGTCVGCESCVGACPVSAISMTDGHAQVDEGKCVECGSCVSTCPVSAISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ5</accession>
    <name>D4MAQ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">clpB</name>
        <name evidence="12" type="ORF">SY1_22660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22660"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1510"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="417"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="870" mass="96917" checksum="EBAD40BDEBB728E7" modified="2010-05-18" version="1">MDFNKLTTKSQSALAAAQDLAAARSHQQVDVEHLLLALLQDAEGLIPRMLRRMEVDPKVLEKLVSDEVARMPRVSGSGAEPGKVYVTPRLSRLLAAAEERAKALKDEYVSVEHLFLAMLDEGTNTNLGRILNRLGITEDRFLKALTEVRGSQRVQSADPEATYEALAKYGRDLVAAAREGKLDPVIGRDEEVRRVIRILSRKTKNNPVLIGDPGVGKTAIVEGLAQRIVRGDVPEGLKDRTVFALDMGSLVAGAKFRGEFEERLKAVLNEVKQSEGRIVLFIDELHTIVGAGAAEGAVDAGNMLKPMLARGELHCIGATTVDEYRKYIEKDAALARRFQPVTVDQPDVEDTISILRGIREKLQVHHGVRIRDNALVAAAVLSNRYITNRFLPDKAIDLVDEACAMIRTEIDSLPSELDAASRRVMQLEIEETALKREQDAASQERLKVLQKELQEARTEADALRAQYEAEKKSIVGIRQLRSQIDEVKAEIERAEHQYDLNRVAELRYGKLQKLEEELKAREAEKEGQNAPGSLLREEVTEDEIADIVSRWTGIPVTKLLEGEREKLLKLDEVLHRRVVGQDEAVQLVADAVLRARSGIRDPRRPIGSFIFLGPTGVGKTELAKTLAEALFDSEENIIRIDMSEYMEKHSVSRLVGAPPGYVGYDEGGQLTEAVRRRPYSVILFDEIEKAHPDVFNILLQVLDDGRITDSHGRLVDFKNTVIIMTSNIGSSALLEGITADGKISESARRKVMDALRGAFRPEFLNRVDDIVFFKPLTRDEVRQIVRLLLGHLEERLADRQIALHFSDEAVNFIGEAGYDSVYGARPLKRYITHNVETKLARALIAGGIRDHSEVDVGLKDGELTFSFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT7</accession>
    <name>D4MAT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_23190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23190"/>
    <dbReference type="HOGENOM" id="CLU_1893144_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1398-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="134" mass="15470" checksum="E55E83642D7EA9D1" modified="2010-05-18" version="1">MATRYRNRRDKDEHVLRLMAGIFMQRINSGLIKDALFCLPQWRTSRRLSWPCRIWARYEDNDARDVGWLYNKLMSELTDLGIKEEDLRLTLSTSMPDAGGGGRTTAGGFSANALDVRDISRDFAQEKADELRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY3</accession>
    <name>D4MAY3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CMP-2-keto-3-deoxyoctulosonic acid synthase</fullName>
            <shortName evidence="2">CKS</shortName>
            <shortName evidence="2">CMP-KDO synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kdsB</name>
        <name evidence="3" type="ORF">SY1_23940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23448"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.7.7.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.38" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23940"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1641"/>
    <dbReference type="HOGENOM" id="CLU_065038_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00358">
        <property type="reaction ID" value="UER00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033468">
        <property type="term" value="P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00057">
        <property type="entry name" value="KdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="249" mass="27085" checksum="753CD7BF21EF5E6D" modified="2010-05-18" version="1">MNVKKILGVIPARYASSRLPGKPLADICGKPMIQHVYERTMAARRLTSVAVATDDERIASAVRAFGGCAVMTSPDHPNGTSRAEEALRILAPDADAVVNVQGDEPLLDPATIDEVAALLDEPGVSFATLCRPMADADRDNPNAVKVVMDQNGDALYFSRSLIPYPRNKPRLPVYCHIGLYAYTADFLRHYAVLPMTPLAEAESLEQLKALEHGHRLRVKVTASSAEGVGVDTQEDLERVRTILRERSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB04</accession>
    <name>D4MB04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase-like enzymes, putative cysteine proteases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_24230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24230"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1664"/>
    <dbReference type="HOGENOM" id="CLU_012397_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1466-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="411"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="661" mass="72252" checksum="B920F2C7E24870FA" modified="2010-05-18" version="1">MTSPAAVGVPRTRPIRFYLDLLLPVCGLMCFAMARDGVSAAAGWAFLLGLATVGAASFLDLPRPPGFVIFTATLLLLIPILGQISLRYAAEPLLEATLLLFLLRVYEKRGPREYVQVVIILLAAVVIYAVLSIERVFMTVCVGMGLAGSMILMLSAWMRREPDARLGWSDVKGLFVRALGMFLVMLPLCLLLFFAAPRFRSPFRIAQGGLGATTGFSDQLTLGDVGQIQESGRLAFRAEVRDIAPRTPYWRGVVLSLFTGDTWTVNLAGRRGGWDVPTSGGGNLRYSIQLEPGGHRWLFTLDRPVALWGTEALDLGNGTYARRSFNGARYEAESALDPAGGGSLTPRDEALYLQLPEGYSPAVRRLAEEIAGGAEEDREKMEAVIARLSGGEYRWTLRSLAQGRNALEDFLLRLKRGNCEYFASAAGVMLRMLGVPARLVGGYRGGDYNRTGGFYSVRDLNAHVWVEAWDRSSRAWIRLDPTPTALEDEADAAVLVSGGGWGEFWDYLDYQWNRYFVAYGGSQQAQWVGALRSLLRNPRAALPSMGGFADGAGRGASRAAFALGAAVLALAGGWGVWRYAHRDERTALLRRFDRLMARRGFVRSPCVGLLEFAWALPEPLRANALDFALGLSAVFYGGRELDGPRREALLRALSALSSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M739</accession>
    <name>D4M739_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type antimicrobial peptide transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_01190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01190"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.389"/>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-66-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="310"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="404" mass="43253" checksum="E3320BEE907A36FA" modified="2010-05-18" version="1">MFETLRTALSSLLANKTRSLLTMLGVVIGVGAVIAMVAVGNGASVQMQDLVSGLGSNLLILSPGAPRSGGVRQSGGARLTLSDVRAVTEECWSVLRAAPLVNLSSQLIYENQNWPSRVTGTTSSYFDVDNRSIYLGRLLDDEDERSASKVCVIGQTVATQLFGTTNPIGKNIRINKIPFEVVGVLAPKGGGSMGQDQDDTVVVPITTAQRRLVRSSLADSVHMALIQVRDVSMLEGGMADIRALMRQRHRIGRGKDDDFEIWNMTQMVESLQQSTWVMSALLGAVASISLLVGGIGIMNIMLVSVTERTREIGIRMAIGARARDIRLQFLLEALVLSLLGGALGILLGMAASWGVTKFLTWPTSVSSGAIALAAGFSGFVGVFFGLYPAWKASRLRPIDALRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M751</accession>
    <name>D4M751_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01430"/>
    <dbReference type="HOGENOM" id="CLU_023257_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-78-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="182"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="378" mass="41705" checksum="180101C46BAEA246" modified="2010-05-18" version="1">MKTDVSKYLTLRRDIHRHPELSNHEVETTRRIREFLALDGLELRPIGGLNGGFVNVNTGMEKTLCMRADIDALPLHEETGVSFASENNGVMHACGHDMHTAIAAAIACELHKVRELLKCNIVVLFQPAEENNPDGGAKPVVEAGFLEDQHVDEVYGLHMWPQLPVGDIEVCPGPIMAASDRFSVRITGRTAHAAEPHLGVDAIAIGMDIYCALVQKLRREVSPCDSMTISIGSFKTSGRYNIICPEAVLEGTIRTTSDGTRAFLPKRIAELSSTIASSYGGSADTNVNRGYGIVVNDVDLFRRFSTCAVKTLGPEHVHTNIRPSLIAEDFYYYGKRVPSLYFHLGCQSEYSLHSNRFLPKEEALTVAVDLMTDYFLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M762</accession>
    <name>D4M762_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_01560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01560"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.726"/>
    <dbReference type="HOGENOM" id="CLU_141525_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-88-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="119" mass="12921" checksum="6FFD617879BF830E" modified="2010-05-18" version="1">MPNFPDPFAGNVERKMSREELVQALRIDIAGELEAIFLYDAHAQATDEPLARKVLMEIRDEEKAHVGELTTLLSRLDPNWSESLAGGEGEVLETMQELGIAPAEGASDGQSTVGSLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M772</accession>
    <name>D4M772_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01720"/>
    <dbReference type="HOGENOM" id="CLU_2034669_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-98-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="121" mass="12815" checksum="CF3597CFA4F622E5" modified="2010-05-18" version="1">MTKLLNRMTDEVQAVGRIAFGAADRRGKIVAAVGDGERLRYTVNGGPREAFDDAGLRTLTAEFVRFALDSDLSCLALEVEGVDALSPQASEAAAEGALAGACAFTKYRTQGAARANWPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M791</accession>
    <name>D4M791_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_02020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02020"/>
    <dbReference type="HOGENOM" id="CLU_059021_5_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-118-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061730" evidence="1">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="30"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="238" mass="25008" checksum="54A956BADB2088BA" modified="2010-05-18" version="1">MKGYRLLGVLAAALLCTPAQAAKVEVETGARLLPTTACLVGTYDAEGRPDAAIIDRVGIAETPSKQRMIFYVAVNPKRQTAKNIEATGAFTVNVMNAALVPQGDFCGTVSAASGDEYFDKFSVTGLKLEKGSDVNAPVLTECPVTLECKLVKTLEFPDGQHRVFLGEVASYHVAAEALDGDKTAPVSQFDPQKSGMAVYFAGSAEGSGYYALSAPLGSGMSAEKFPWPNGLEPKPAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B1</accession>
    <name>D4M7B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MTH538 TIR-like domain (DUF1863)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02300"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1682"/>
    <dbReference type="HOGENOM" id="CLU_098991_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-139-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036490">
        <property type="entry name" value="MTH538_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015032">
        <property type="entry name" value="MTH538_TIR-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08937">
        <property type="entry name" value="DUF1863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52206">
        <property type="entry name" value="SSF52206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1863" evidence="1">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="190" mass="22206" checksum="E07A53415969F1D1" modified="2010-05-18" version="1">MTKVKEKVFYSFYYKQDVMRVQNIRQMGVLEGNEPVEPNKWEEIKKKGDDAVRKWIDEEIARCSCVIVLIGAETASRKWVKYEIKRAWNANRGLMAIYIHNLSPVNDSLASKGLQGQNPLCSFWLRSDEQVLELYTVAPVKNPSEWDAYDEIHENLNCWVQEAIDVRKKYARYTCVPTTVKRIFGKSLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H0</accession>
    <name>D4M7H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_03140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03140"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-200-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="227" mass="24077" checksum="DFE44F8E87A3DA3A" modified="2010-05-18" version="1">MAPVLRLNDLCREYRRGGRRFLAVDHVSLDVEAGSCVSIIGRSGSGKSTLLNLAAGMLSPTAGSVELLGQNLADLEDARLSRLRCDAIGFIPQGPSALPGLTVLENVLLPFVLWPHGGDGEGAARLLLSRFGIEGLADAYPEDLSGGELRRALIARALVNRPSIVIADEPTSDLDAVSRRGVMECLAALQDDGTTLLVVSHDLDTLDFADRVYTMVDGRLTEGNGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H2</accession>
    <name>D4M7H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA nucleotidyltransferase/poly(A) polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_03180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03180"/>
    <dbReference type="HOGENOM" id="CLU_015961_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-202-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="445" mass="49408" checksum="E6822267A024876B" modified="2010-05-18" version="1">MTGGTLPGCGFLEVVEMRHLRVLKTVERTGVRAWLVGDSARMIEMGIEPEVMTLAVDAKDLSSLSDRLDGATVDARGTFPVLRGSVLGAPFRAYSLQGDTIADDLARRDLSIEAIALRSDGGVVDPFGGRRDIRNRVIRLTGDDVELIDRDPLRIVRILRFAAELGMDVFWRTDMDVREFLRCHAERMNAIPAERWGREIISGMKERPWRFISLCDHYGLLPVFLKDLEDLKSVPDGRGRTFFSHVMATLSVIERRLPTHKIMQDEAFILAGLFSRIGTRSLNAGDEGERRRNKALTSSFLSQWNIPAETIRAAQAIIDGYRRFYELRTEEDLCGAVLEHGADAMAAGLDFAGCIARAEGLPHLETLSENRWRLAQVLRRFKAVALQTGGASRFLGGDEVMSLLRLAPGRIIGALLDGLDVAVGTGRVTNRAQAEEWIVSHARSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H7</accession>
    <name>D4M7H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_03260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03260"/>
    <dbReference type="HOGENOM" id="CLU_1052734_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-207-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061810">
        <property type="term" value="F:NAD glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="169"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="264" mass="29349" checksum="7258518C4B11DA37" modified="2010-05-18" version="1">MGDGNDLGFTKNIESTENIGNIESTENTLSESVELSEGAGLERSADLDAPPQDIAEDTELPDAPDAGPDGSYGLTDLEEDTSADFENLNESDASEACPDEIPEDGDTDTEENPSLEAEFEEQRRADDAIRETLRDDIREDPEFIDANGDLIWAPNGGFVENPETVAVQPGSVVLQRWGNESGHHFTEFGTPYEKVSLPWKETEPRYFEILRPLEDVARGTVAPWFRQPGGGIQYRTELREFEMTRGASPYLREISFDEALKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L6</accession>
    <name>D4M7L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplK</name>
        <name evidence="11" type="ORF">SY1_04000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1881"/>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL27861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="141" mass="14961" checksum="E356FEBA81F1926C" modified="2010-05-18" version="1">MAKKVVGQIKLQLPAGKATPAPPVGPALGQHGVNIMEFCKQFNAKTSDQAGLIIPAVITVYADRSFTFELKTPPAAVLLKKAAGVESGSGVPNKTKVGSVSRAKVREIAEYKQRDLNANDVEAAMRMIEGTARSMGLEVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P1</accession>
    <name>D4M7P1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligoendopeptidase F</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_04390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has oligopeptidase activity and degrades a variety of small bioactive peptides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1925"/>
    <dbReference type="HOGENOM" id="CLU_021290_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-272-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061828" description="Oligoendopeptidase F" evidence="7">
        <location>
            <begin position="25"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3_N" evidence="9">
        <location>
            <begin position="174"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="8">
        <location>
            <begin position="265"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="659" mass="74787" checksum="64F7380392CE8614" modified="2010-05-18" version="1">MKGLRTRRALPLLAAACFSCAGLAAGGAAAGVEKFDALTRGVVPMNFAMRFEAPEAMGDGTGGVPERRDVPEAMRWDLEAIYPSFEAWERAFSDLTPKIDALAGFAGRLGEGPKKLLEYLKAEEAVSLELEKLYVYANMKSHEDLRETRPMELASRIEALSARHGVVTAFFAPEVLELPEDELRRWVRGEPGLKLYAFFVERLLREREHILPRAEEALLASAREATAAPENAFSLLTNADLKFPTIRDEEGRSVELTEERWYKLSRSPSRDVRRAAFEGIYGTYGSFKNALAALYAGSVKGDLFYARARRYKDSLEAALFGDNVPRSVYENVVDTAARCAPLMHRLVALRKRALKLDRLHYYDLNVPIAEEPREDIPYERACRMVAEALAPLGEDYVANFKRGLAERWIDVYENRGKRKGAYSWGSYATHPYVLLNYNGTLNDVFTLAHEMGHSMHSWYSHRNQPQVYGDYTILLAEVASTTNEALLLGHLLKTAKTEEERKWLLSYYYNMVRTTFFRQAMFADFELQVHARAEEGGALTPEWMSGLWRELNERCYGPDMAPDELLWVEWARIPHFYSAFYVYKYVTGFTAANAFASAILAGEPGAVDRYLTFLKSGGSDESLNILRRAGVDLTSREPFDRTMKLFQERLEEGERVWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V8</accession>
    <name>D4M7V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05450"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2036"/>
    <dbReference type="HOGENOM" id="CLU_056776_8_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-340-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="112" mass="11999" checksum="EF373778660EC5DE" modified="2010-05-18" version="1">MSDCIFCKIAGGEIPTDFVYRDEDVVVFRDVAPQAPTHLLVIPRCHVASSAEVKDSAVWGALMGAAVKVALSLGLEKDGYRMVINTGEGSGQTVPHLHIHLLSGRNFGWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V9</accession>
    <name>D4M7V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
            <ecNumber evidence="2">3.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EC" id="3.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05460"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2037"/>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-341-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047980">
        <property type="term" value="F:hippurate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="191"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="395" mass="41529" checksum="6970B89CDD6FD566" modified="2010-05-18" version="1">MKGVSVRDEARELNGEMVGWRRHIHLHPEVGFDTGGTAAFVAERLNEAGAVEVRTGVGRSGVTAVIRGARPGRTLALRADMDALPVSEETGLPFASAHPGRMHACGHDAHTAMLLGAAVLLGRHREDLQGAVKLIFQPAEEIGMGAMAMIQDGVLEGVDAIAGLHTGSLWNGADAGEIGFRPGAVMAAADTFTIDVSGKGGHGAQPDRSVDPISIACQVYATLQTVISRETPPLAPAVLTVGSFQAGSAPNVIPDSCTMKGTIRSLSKETRSSLQDRIRTIAEGVAAAMRGSARVAFTYGPPPVVCDPDMTEKLVRAAGAVVGPEHVRPIDEPAMVSEDMAFYMERVPGVFFSHPSTLGGGLDFPHHHPKFTVNEDVLWTGAGTFAELALTWQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z2</accession>
    <name>D4M7Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Virulence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06060"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2092"/>
    <dbReference type="HOGENOM" id="CLU_048266_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-374-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="291" mass="33584" checksum="CD4510E42BB98CD3" modified="2010-05-18" version="1">MKKDEREISIVRSSAAEYLTFITATGESDVNAVYFDENVWLTQKMMGLLYHVETHTINYHLKKIFADGEIDESSVIRKFRVTAADGKSYNTNHYNLSAIIAVGNKVDSPRAVQFRKWANRIIEEFTVKGFAMDDERLKNGGTVLTKDYFREQLERIREIRLSERRFYQKITDIYATSIDYDAKAETTRLFFARVQNQLHWAIHGETAAETIYRRADSSKEHMGLTTWKDAPGGKIQKFDVVMAKNYLTQEELSAMARIVNAYLDLAELRAEEEVPMTMEDWAEQFEGVPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M800</accession>
    <name>D4M800_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAP-type C4-dicarboxylate transport system, small permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_06170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06170"/>
    <dbReference type="HOGENOM" id="CLU_086356_3_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-382-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="182" mass="20574" checksum="390A7CD3B057B175" modified="2010-05-18" version="1">MLKLLVRLKKADNFLYSIQKILILFGVIAMVIINGAQVFCRYVLHSSLAWSEQVSVLLFFILIMLGANLAVKTDSETKVDILKFKNKRTNSALHILTDALSIVALVVFIVSGFALLKHARKFPQFLSSIRLNYFYIYLWLPMGFGLVLFDKVINVLENTCVLMGIDTSTSCNSEKEMEQAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M816</accession>
    <name>D4M816_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_06390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2125"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-398-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="273" mass="29527" checksum="39D95B67F144D6CC" modified="2010-05-18" version="1">MSAPLLEVRGLRIETSERAARPLVRDVSFAVRRGRVTCLVGASGSGKSLSCTAVPGLLPQGVRRTGGAIRFEGRPIDALPARELRELRGTRIAMVLQDPISCFDPLFSIGSHFRETLAAHGGDFGWRGRAEAALREVGLEDAGKICRAYPFQLSGGMLQRVMLALALLNDPSLLIADEPTTDLDTVAQRRVLDLIDAARRRRDMGVLLVTHDFGVVARVADDVVVLEEGAVVEDRPVGEIFSSPRHPVTVALVEAHRALCARLGLLQEGGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M841</accession>
    <name>D4M841_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_06750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06750"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2168"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-424-MON"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="153"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="246" mass="25478" checksum="EE45402C4AB146AE" modified="2010-05-18" version="1">MARRVALVTGGGRGIGRAIVLELARNGCDVAVNYAKSADAADETARAASALGVRAETFGADVSDRAQAEALFKAVREAMGPVEVLVNNAGITRDGLLVRMKPDDWDAVIAANLSSVFYCTKEAVRDMARARWGRIINLASVVGLIGNAGQANYSASKAGLIGFTKSVAREYAVRGITVNAIAPGFIDTSMTAVLKEDVKAAITTQIPMGAIGTPDDVARAAAFFASEGSSYITGQVLAVDGGMTMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M843</accession>
    <name>D4M843_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dioxygenases related to 2-nitropropane dioxygenase</fullName>
            <ecNumber evidence="2">1.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06770"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2170"/>
    <dbReference type="HOGENOM" id="CLU_038732_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-426-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="83"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="317" mass="32834" checksum="E72117B0435C4026" modified="2010-05-18" version="1">MIRNNRVCELLGTEYPLIQGGMAWVANASLAAAVSNAGGVGLIAAGASPAEVLEQEILKARSLTDKPFGLNIMLMSPTAPDALELAAKHRLRIVATGAGSPGKVLERLKPLGTIVIPVIASVAQAKRAEKQGADAVVAEGTEAGGHIGELTTMVLTPQIASAVKIPVIAAGGIADGRGVAAAFALGAEGVQLGTRFICCSECTVHPNYKQAVIDARDRSTAVTGQSLGHPVRCLRNRLTAEFERLEAEGAPAEEIEKLGMGKLRAAVVDGDTEWGSLMSGQSAAMVNDVLPAREIVRGLFDEARRVLHGIRDAAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M861</accession>
    <name>D4M861_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Soluble lytic murein transglycosylase and related regulatory proteins (Some contain LysM/invasin domains)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_07080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2197"/>
    <dbReference type="HOGENOM" id="CLU_013746_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-444-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061525" evidence="2">
        <location>
            <begin position="33"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="525"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="670" mass="75260" checksum="9552E53CE476B71D" modified="2010-05-18" version="1">MLKKRFVVERCAVLALLMGLAAALLSALPAGAATMQDLFWKRAWKEMEVLYASMDERSPQDAALMANAYRIQDRWPDAVAILEEYAGKFPASIRPYADMTLLLGYERGKRDQEALALAERLWKSAPQELKYYVAYAQYRLLSKGGDERRIGEALSHMLAAAETKERRIYALSKRIELSGNRAESALKLLELQPSNKDAAKVLLQQPQPWSNAVRVALGVYAHLAGESAAAEERLRPVPMTAAGGRKAAYYRAWSLYRLKRSGEALDLWSRLALSGNAYAEPSVRRIATLAGKAGKAEKKAAMNVLERVIKERRGKPQARALLVLRDLLDKSQAKYRDALEAKVLSAYPDTPYAFDVLWGRGWKNVAAGNLTEAVRLWRQADAPNIGPMRRARLLYWIADAERRSGNKAEADRTQALLERRYPLSIYALLNGGEKLKVVNGEDPALATKPSELEQWGFVLYAKLRLSRPKAGVRELYRALRLSRWLGLEESYNEARRLETLLTSGRTLYRANLEALYPRPFRAQVKAACEAYSVEDALVWAVMRQESSFRPDARSHAGATGLMQLMPGTAKGEAKRAGLEKYDLLDVNDNIRLGTSHLAWLGRSFPRVEWVMAAYNAGSGNARKWLKNGGEDLPLDRWIEAVKFDETCGYVQRVSANLRVYRMLYGTAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M882</accession>
    <name>D4M882_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07450"/>
    <dbReference type="HOGENOM" id="CLU_060275_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-465-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="280" mass="30544" checksum="E207395CB09FB101" modified="2010-05-18" version="1">MDVDFFNAILDRQSQDASEAEAFWDARAESFLASKRTYGADLTERVVRCLTGGGMLGPETSVLDVGCAYGSYALPFAAVAKDVVAADVSSRMLELCAERAKAAGASNLRILKHDWELDEIGDLKGCFDLVFACMCRPARTSSGLAKMAAASRGVCVVAQYVAMEDSLAESMAGELGLDRGDDPHNDRSIAWAIFNRLWLDGFLPRMDFAERIEDRTLTLEEALDRYGMGLGRAASERGTDLRSLLSAREEKGGVRTRARAVLALISWRPSERGHFTAPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M884</accession>
    <name>D4M884_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="5" type="ORF">SY1_07480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2236"/>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="185" mass="21014" checksum="6A4A1DBA17CA3F82" modified="2010-05-18" version="1">MPKDELKELQESMDKAIDFLQNEYLSIRTGRAHPGLVSDIKLDYYGTPTPLKQIANITIPESRTIQIAPFDRTSLKAIEKAILAANIGMTPQNDGASIRLTLPELTRERRVELTKLLAKKAEDARVVVRNYRRDAIESLKKQEKASEITEDDLKTLTKGVQDKTDAYVKKVDEIYKAKEKEVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B8</accession>
    <name>D4M8B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug resistance efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_07950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2288"/>
    <dbReference type="HOGENOM" id="CLU_018816_6_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-506-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="2">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="343" mass="37716" checksum="3B589CFC6109EF6C" modified="2010-05-18" version="1">MKKRFALLLLVLAAVLGALYANGELDGLIDRFREKDPHRIRLYGNVEIRQVLLGFRVSGRVEAVYREEGERVASGDLLSILDPVPYRIKRSEARGAMLQAKAALDKLHRGFRTEEVREAAAQRDRVQASLDLAEKDYSRISNLFAQKAVAKSELDRASSQRNALRAELAAAENALALMREGYRREDIEAAEAAYEAASARFAAAENALSDTELRSPADGTILTRVTEPGTVVGAGQVVYALALERPIQVRAYIPEPQLGRVRVGMPAQIVTDSSPAPIEGTLTFISPTAEFTPKQVQTEDLRTDLVYRARILVEDDRDGRLKNGMPVTVLMESIEASEGAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D0</accession>
    <name>D4M8D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_08130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08130"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.13"/>
    <dbReference type="HOGENOM" id="CLU_1458411_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-519-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="183" mass="20535" checksum="757D65B908AB364F" modified="2010-05-18" version="1">MKVSRVKVGMGVLVVGIVALVRYAMRDMRLDVDLLREGLMNIPGLVMENMQLAREVSGDVWHVRVPYLERRGELVAVRSVDVRRQIREGGEWYLFGAEGVYSNDERTACVNGLLGTLEAPARIWNLESPRLLWSEASGDFVFPRGLTLYDDEFLLSAPEASMDRTGVVLLEKGGQLQWTKPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E6</accession>
    <name>D4M8E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_08430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08430"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.40"/>
    <dbReference type="HOGENOM" id="CLU_024775_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-539-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="7"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="407"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="497" mass="53817" checksum="1F3BECCD3C3B58EB" modified="2010-05-18" version="1">MSREEFDVAIIGGGVVGASLARELTRWRVRVVVLDRAAELPSGASRANSSMIHGGFDDSPNTLKARFCPEGNRMYHALKDELDFHLDECGSYVCAFDDKDMAHLEKLLVQGRANGVPGLEIVTRERLRGNEPNVSPDVKAALWSPTAAIVNNFEAVVAFMESAKINGAVLRLETRVTGLMLDDRGEVRGVETDRGPVYVPIVVNAAGVHSEEVASWAGEPDFHITPTRGEYFLLDRTAGDFVTSFLFACPSERGKGVTVARTAEGNLLAGPTATVQKDRDDTATTPEGLAQVLEGARRLVPNFPVNLNITTFAGVRANTDTGDFVIEALKAPRGFVNVAGIKSPGFTSAPAIAVHVAEMIRAELGDRASFEPNPHFVPERRGIPRFAELPMEERARLAREDPAWGQIVCRCETVTEAQVLEAIRRGARTVAAVKIWTRAGAGRCQGGFCCPRVAEILARELQIPLTEVTRHGGNSRLLLGGAKEFLLDEGRGEEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E8</accession>
    <name>D4M8E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_08450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08450"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.42"/>
    <dbReference type="HOGENOM" id="CLU_020019_9_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-541-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="244" mass="25670" checksum="DBAD708F82D7932D" modified="2010-05-18" version="1">MQSWLGPVFGEFFGTLVLIVFGDGDVAATALKGSKGEGAGWVHVNWGWAWAVVMGIFAAQATGSPQADINPAVTLAKFMAGTYAANEALVVMAAQFVGAFLGAVIVYFAYLNHWEGTAPDAQLAVFCTGPARRNYPCNFLTEVIATFFLVTGIMCIFSKGVGGQGGWMGAFMVGGLIYVLGAALGGPTGYSMNPARDFGPRVAHFVLPMAGKRDSDWGYAWVGTIGPWAGAAVAFFFCRAFGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8F3</accession>
    <name>D4M8F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">SY1_08530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.50"/>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-546-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="348" mass="37555" checksum="363D69154152C4BB" modified="2010-05-18" version="1">MFGTDIGIDLGTATVLIYERKHGVVLREPSVVAVDQDTGNILAVGYEAKNMVGRTPGSIVSVRPLRDGVIANYSMTEAMLQHFMRRVTKGWQRFFRNRVMICVPSGATDVERRAVLEAALEVGASEAYLIEEPMAAAIGASLNVEEARGKMLVDIGGGTTDIAVISLGGVVVSKSLRLGGDKFDEGIMRYLRRQYNLAIGEQTAENLKIMIGTCVPLEEDQRMVIKGRDLVQGLPRQVEVTSSAVNMAIGEMVQTLVDGVRNVLELTPPELSADIIDRGIVLTGGGSLLRGLPELVAQQTGINCFTAENPMESVALGTGRALAEIDSLRSSGRSGILVNLKKGRRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8L5</accession>
    <name>D4M8L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type transport system involved in Fe-S cluster assembly, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_09570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.159"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-609-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="245" mass="26901" checksum="ADCE89DD31D95530" modified="2010-05-18" version="1">MLELRNLSFSVDNDGVRKEIVHDLNLIVDDNKFVAITGPNGSGKSTLAKLIVGIEKPTEGQILLDGLDITNMGITERARKGMGFAFQQPVRFKGITVHALLRLASGKDLSVSDACDYLSEVGLCAHDYIHREVNASLSGGELKRIEIATVLAKHSRLTVFDEPEAGIDLWSFQNLIRIFESMRRGIRDSSIIIISHQERILNIADEIAVLTDGTIERHGTKAEVFPDLVGTEAAQGPCSRLRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8L7</accession>
    <name>D4M8L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactate dehydrogenase and related dehydrogenases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_09590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09590"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.161"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-611-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="14"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="110"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="318" mass="34478" checksum="FCE1B4D1D6737FF8" modified="2010-05-18" version="1">MSKVYVTRMLPRPVMEELGRVCEYAANEEDRPASREELLSGVKGCDGVISMLNDAIDAEVMQAAGPQCRILANYAVGYNNIDLAEARRLGIAVTNTPGVLTDATADLAWALLFAAARRVPEGDRLVRHGSFNWAPEFMLGADITGRTLGVIGAGRIGLNFARKARGFDMKVIYAGRHRSSEFEAETGGTFVTKEELLRTADFVSLHVTLTPETRHLIGEPELGMMKPTAILINASRGPVVDEKALVRALRERRILAAGLDVYENEPEVEPGLKELDNVVLTPHVGTATVGTRTEMGFMVVRNVAAALAGQEPPNLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M0</accession>
    <name>D4M8M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="10" type="ORF">SY1_09620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.164"/>
    <dbReference type="HOGENOM" id="CLU_007894_4_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="467" mass="50106" checksum="5315AA68BC62FC3E" modified="2010-05-18" version="1">MNRRDRLRLWVVLIVIVAALAYSWPIKGRINQGLDLRGGAHIVLQAKDTPENPVGPDSIDRLLAVLRNRVDQYGVAEPIIQKSGEDRIIIDLPGIQDPKAALELIGKTAQMDFREVMDVTASTLSAPERKNYDSDLQFSQAQERWRAAVEAQSNSSADLAARARGIEGAIVAPSEEEEGEAARFYLLGKSLLSGKDLETASVNPDRLGRMGVSLSFSPEGAKLFEEATARLVGKQIAIVLDNVVISAPVVQDRISGGEAQITGRFTAEEASRLAIMLKAGALPVAVEIAENRSVGPSLGADSVRQGMQAGLFGAAMVLVFMLIYYRFRGLAADVALVVTILLIFTGLIAFHATLTLPGIAGIILTLGMAVDGNVLIYERIREEVRSGKTPIAALDAGFRKALVTILDSNITTLIAALVLFHFGSGSVRGFGVTLSIGLVASVFANVVVTRALLQLFVSRRQNALKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M4</accession>
    <name>D4M8M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09680"/>
    <dbReference type="HOGENOM" id="CLU_2206211_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-618-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="107" mass="11162" checksum="3691300BB10AFCA1" modified="2010-05-18" version="1">MERTPPRINSLARRWIRDVISGDAGPPLGGSYLMPPSSGGLWDGVITRPSATAAPTSRLCARMAREMTGVGVGANPSCSTTSTPFAARTSTQVRSAGSDRAWVSAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N9</accession>
    <name>D4M8N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SY1_09950</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.195"/>
    <dbReference type="HOGENOM" id="CLU_001370_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-633-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="495"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="533"/>
            <end position="540"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBL28234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="830" mass="89901" checksum="659D2258A46FECFF" modified="2010-05-18" version="1">MNETDAPKAIQVRGARVHNLKNIDVNIPLNRIVGIAGVSGSGKSSLALGVLYAEGSRRYLEALSAYTRRRMTQAAKADVDEVLYVPASLALHQRLGVPGIRSTFGTGTELLNSVRLMYSRLANHVCPNGHPQEPTLAVAAEQELVCPVCGARFHAPSAEELSFNGQGACERCGGTGMVRTVDEATLVPDESLTIDEGAVAPWNSLMWSLMTDVCRAMGVRTNVPFKDLSGREKDLVYHGPAEKRHILYKAKNSNVAGEMDFTYYNATYTVENALAKVKDEKGMRRVERFLKEEICPECGGSRLSERARQPKLRGVSLDVVCRMPLSELLQWVEAVPGSLPREMQPMANSICESFRTAARRLMDLGLAYLSLDRAASTLSTGERQRMQLARAVRNRTTGVLYVLDEPSIGLHPANIAGLNAVMHDLVADGNSVLLVDHDMQVLKEADWLIEMGPQAGAEGGRVIAEGTIADIEKDAASQIGAFLAGGRRVERERPLRPNGTFAEGTIRLVTSAIHTVKPLRVAIPRGRLTVVTGVSGSGKTTMVLESLVPALEAVRQGKRAPEHVVEVAAECIEHVKLIDATPIGVNVRSTVATYANVHDELRKAYARTQDAKRHGYKSGDFSYNTGSLRCPVCDGTGSISLDVQFLPDVEVPCPDCHGSRYAKAACQVRHTNGAGVSRSLPELMDMDVSAALEFCREMKTIRSKLRVLQSLGLGYLRLGEDTPGLSGGEAQRLKLASEMGREQADSVFVFDEPTIGLHPLDVQTLLNVFQTLIRNGATVVVIEHDLDVIRNADHVIDMGPGGGEAGGTIVATGTPHEIREDARSVTGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q8</accession>
    <name>D4M8Q8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_10350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.245"/>
    <dbReference type="HOGENOM" id="CLU_075245_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-659-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="320" mass="34340" checksum="C2B977E39AF03D01" modified="2010-05-18" version="1">MIDVIKKIRDIGIVPVVKLDSSEQAVPLGKALIAGGIPIVEVTFRTDAAEESIKKLVAELPEIMVGAGTVTTIDQAKRAWAAGAKFMVSPGFNPNVVRWCIENNIPITPGVNSPSQIEQGIESGLSVLKFFPAEQSGGVNTLKAFAGPYGSVMYIPTGGVNLKNMCSYLAFKNVLAVGGSWMVKPDTIAAGKYDEITKLCREAVITGLGFELRHVGINDPDEDAARRDAARMEELFSFTSKPGNSSIFAGVGFEFMKSPYLGKNGHIAIATYSVDRAVAWLANLGVKTRPDTEKRDSMGSLTVAYLDEEIGGFAVHLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R0</accession>
    <name>D4M8R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_10370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.247"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-661-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="259" mass="28466" checksum="25CBB7C5C850A1E6" modified="2010-05-18" version="1">MSLLEVKNLSIMFGGLCAVDDFNLEVEKGELIAVIGPNGAGKTTVFNMLTGIYKPTSGVITLEGENMVGLKPYQFAQSGIARTFQNIRLFSNATVADNVKMAHTMRNKQNIFKCLLRTPGMIRSERALDEKVMELLSRLGLADKADIPAKNLPYGDQRRLEIARALMTAPKILLLDEPVAGMITAELEDMAQLVSKIRRDFGLTIILIEHHMNFVMPIADRIKVLDFGKTIAEGLPSEVQTNPLVIEAYLGGGYQDANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R4</accession>
    <name>D4M8R4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_10420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.252"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-665-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="385" mass="42466" checksum="0EC805F2A19DE889" modified="2010-05-18" version="1">MNFLNKKAKGLEQGAIRAMFDKAIGMSDVISMGIGEPDMPTPSLICEAATEALNKGITHYTPNAGAFELREAIAQKSTVKEIGYDPWTEIIITNGGMGALSLLFLVILDEGDEVLIQDPQWLNYVAQVQYCGGKAVRVPTKSQDNFQMSAEVIESLITPRTKALMINSPNNPTGEVMPWSNVEKIAEVVQRHDILVITDEVYNTLTYGDSLPYRSIASLPGMKERTVVVNSFSKAYAMTGWRIGYAAGPSDVIDRMVKCQENFNACVNAPGQYAAVVALNHPELTKELRDVFAGRRKAFLEGLSNIEGIRCNEPEGAFYAFPDISAFRMTSQRFCERLLLEQRVVCIPGSAFGECGEGFIRVAYTCGEEKLLEALERLRTFCAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T0</accession>
    <name>D4M8T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10770"/>
    <dbReference type="HOGENOM" id="CLU_1728718_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-681-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="151" mass="16738" checksum="2B5E898EE2ED47D9" modified="2010-05-18" version="1">MQKFRGKDIAVFVLVLGILAAGVYSLIGSGGSSINTPAIASMTPEELAAENEMLTKQAHDASMELQMIAAGGSKSANMWVEKYCKDRKDAPLPEDPAAANIELKARVREARTVFEELQAEQRKEMHWLTQYYAEENEQTLEKLGIQSHKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T8</accession>
    <name>D4M8T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein ChrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_10890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.298"/>
    <dbReference type="HOGENOM" id="CLU_018106_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-689-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="193" mass="20476" checksum="94D04053CC92E35B" modified="2010-05-18" version="1">MGGAAEAWKLFVQFFRFGCFTFGGGWSIVAQMRERYVEKEGTLTNEDLLDLTSIGRSLPGTMIGNIAMFYGYRRAGLPGGAACVLGMVLPPTLILMGVTCAYAALQGNVWVLAAMRGVRAAVVPIILSALAAMVRGAFRFPPCAAVAPVTFALYAFPGVSSVWLVLLGAVCGLLICEGYERKGVDRRGTGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U7</accession>
    <name>D4M8U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_11000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11000"/>
    <dbReference type="HOGENOM" id="CLU_3080184_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-698-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009366">
        <property type="entry name" value="Protein_Veg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06257">
        <property type="entry name" value="VEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="52" mass="5840" checksum="E4B0D4E6EEB17475" modified="2010-05-18" version="1">MSKGRNRVEETEGILTDVYPKLFTLYNNSTASTISFSYAEVLTHEVELEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V0</accession>
    <name>D4M8V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11040"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.315"/>
    <dbReference type="HOGENOM" id="CLU_039478_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-701-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="321" mass="34883" checksum="3BAD24356C4D2FA4" modified="2010-05-18" version="1">MSARELKQPATAFASPRFCNVGNFMRMERVADPDGLDFAVYGIPFDTACSYRSGARFGPQGIRNISVMMKTNHPVHEVNIFDYLKGADMGDVNVVPGYIHPTYAAIEAFASGILDAGALPIALGGDHSITLAELRAVAGKHGPVSLIHFDSHADINDEVFGEKYNHGTPFRRAIEEGLIDPHTSIQVGMRGSLYDAGEFKLAADLGLKLIPTHRVREMGIPAVLDEIRRRVGENKAFLTFDIDFIDPAYAPATGTPEVGGYSTFEAISFIRGLTDVNFAGFDVVEVAPPYDVAEITSLAACNIVFEFLSVLALQKKEGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W2</accession>
    <name>D4M8W2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_11260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.334"/>
    <dbReference type="HOGENOM" id="CLU_025778_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-713-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="133"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="350" mass="38983" checksum="379042F21313954B" modified="2010-05-18" version="1">MLISFVSFVIVIAVCVVVHEFGHFITARCLGVQVHEFAFGMGPALWQRKSTGPEPMLWSVRAFPVGGSCRLAGMGEEEREEAVLPGKGFNEQPGWKRFLILLNGSLFNVLLALLLTAVFLWGHGALDMEHTRIGEVMPGFPAEAAGIQVGDSITAVNGRSVQEWREMSEALREEAERGGDVRVEVRRGEEVLTISTPIPMSEEHGRPMLGITPALVRYSPKDAVLNAGQYTWRMTTLMLRGITDWILRRQEVDVTGPVGIASMSGQAMRAGWWAFVTFVALISLNLGLLNLFPIPALDGGRILFVLLEMVFRRRLPERVENWIHTAGFVLLILLMLAITCQDVYHLFWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M921</accession>
    <name>D4M921_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12100"/>
    <dbReference type="HOGENOM" id="CLU_626650_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-774-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="437" mass="49158" checksum="07A5B726373B232B" modified="2010-05-18" version="1">MNASQEIQAVIEALPDPVLILAPNRGRVLAYNKAFVDKWGFAEETFMDKPFLKMPQFSRAIQRGLIGVYAKARHRRAEIAPFSFCYPDMKGFLKTFSASASPIEEAGSVDVPCVMLRFQELPQMDEATIRAQKDSEAFNIFTDITDEPWLEFRPPLPIVAPGIEDSDRRDHLAHIGKHLRLVRASKAAIHFYGLVERDMESEDGAIKLKEKNFPAFFSRSEDACRMLDILTTIGFIRARSALLDRKGNVIEAEVSCASQFGQGNSLAAIYCIFHFSEEMINCRNAFREGQQMRDFTFNQPFLGLGQLVPQRPLKRPEAESAEAELGKLVNAILLVAANDALLKLHNAQKSRFLMQPMSVLFPNTSHAVAVLRELFVTRESSFALYDGNGTLQHITIFKAIFNDADELVRILISTSDHSQGIEEHYNNQPIPLRPKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M922</accession>
    <name>D4M922_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12110"/>
    <dbReference type="HOGENOM" id="CLU_071039_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-775-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="328" mass="37468" checksum="4222AA2734F575E7" modified="2010-05-18" version="1">MSGKKKDPSEKAAKEPRRDDLLWKDILNRFFVPMLHSLLPDLARDLDEKRDVVFLDKELRRLARFTQRSEGGEPDGNRFVDLLANVPLRTQEDAWILLHVEVQGRGGNEDFPLRMHRYRGLLEGRYRRHVSALALLIEPLSEAQSYGIYSWEGYGTRVKYEFPVFKLYEGDEEALKASDNPFDWAHLAGLRAWKSRSSEPRKLSYLKEMLKLLDEQGWPHADKAQLLVFMEGVIHLTEDESSREYEEWESALEEAKEAGRMYVSIMERKGIEKGIQLGRTEGIQLGEARGVAATARRMLGMSFTSEQISQATGLSPDEVAALRAGTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M951</accession>
    <name>D4M951_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12650"/>
    <dbReference type="HOGENOM" id="CLU_2522734_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-804-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="84" mass="8735" checksum="C085E302366B1234" modified="2010-05-18" version="1">MNRSLAVKFAMSRPTGASSCDAAASFARASRYVVDFPVDALLVASIIILAILALIVMICGQRAVVLSVVAVVLAVVVGDEKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4M956</accession>
    <name>D4M956_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="1 5">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_12720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1 5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12720"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.505"/>
    <dbReference type="HOGENOM" id="CLU_1228442_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-809-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="225" mass="24688" checksum="3532DC7D5D2C86E9" modified="2010-05-18" version="1">MDGRIAGAQSVLENPAWVLSGLNYLHMNAGRGISVLMPYSDHLEKFGEWFAQLWGESLGKEGKGSTPVRALGAIDQHSQIQLYTSGPDDKLYTILTVEQDKRDIALPAAPEKALKKLSYLYGKSMDKLRNFEAQATAAALHKVGRPVAVLSIPALDARCLGALIHFYEYVTAMTGWLLNVNPFDQPGVEQGKKYTYGLMGREGFEADAEEVRTLSARTTERVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4M962</accession>
    <name>D4M962_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 14">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 14">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="16" type="ORF">SY1_12830</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 14">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 14">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 14"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12830"/>
    <dbReference type="HOGENOM" id="CLU_060087_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="15">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBL28407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="387" mass="42242" checksum="4B52BD9960A345F8" modified="2010-05-18" version="1">MHVTIVTAFPEFFRDFLSTSIVGRAVKRNLLRVDLVDLREFGRGGYRQIDDYAFGAGGMVLAAPQLEDALNAARGEGEACVVYPSPQGTLLTQEIVETLSRQEHVVILCGHYEGIDERFVEREVDLEVRVGDCVLTGGEIPAMAVIDAMARLVPGVVGRGEAVEEDSFYRGMLDHPHYTRPASWRGMDVPEVLLSGNEAEVRTWRRARAVERTLIRRPDLLARAAIGDYLSGGARLALLTADGPTPEGAEALSSLCRFYGLGRPFFVILRPDERRSFDALSAGASGVPRVLGSLSRVWDWARSHGKGRPTLTVVVEAQPRSGSLHTLEAKRRCLEHDGPLLFLFPDGVEAGEIAEGPAVYASVAQEAETLPLAVRAGIALDRFLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M984</accession>
    <name>D4M984_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_13230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13230"/>
    <dbReference type="HOGENOM" id="CLU_018288_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-840-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022946">
        <property type="entry name" value="UPF0313"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013704">
        <property type="entry name" value="UPF0313_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32331">
        <property type="entry name" value="PTHR32331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08497">
        <property type="entry name" value="Radical_SAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01069">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03904">
        <property type="entry name" value="SAM_YgiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical_SAM_N" evidence="6">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="349" mass="37991" checksum="681DD938C8A1D76B" modified="2010-05-18" version="1">MAVGGSTQRQAGGGFLPVCRADMEARGWSELDFLFVNGDAYVDHPSFAVGLISRLLEREGYRVGVAAQPNWRGDEDFTCMGRPRLGVLVGAGNLDSMLGKLTAGKKARRTDAYSPGGAVGLRPDRATIVYCQQVRRIFGDIPLVIGGIEASLRRLVHYDYWSDSLRRSILLDSQADLLIYGMGERQLLEIAAALKRGVPVGEVRDVRGTCYVAERGQEPAGSVPLPSWDEIVRDRRKFAEAFRLSSLEQDALRGRTLLQGHEKGTLVQLPPALPLTEAEMDGVYDMPYLRRWHPKYDALGGVPALAEVKFSVTSHRGCFGSCAFCAIHAHQGGSFRPGATSPSCGRSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M993</accession>
    <name>D4M993_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_13380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="TCDB" id="9.B.8.1.10">
        <property type="family name" value="the duf2157 (duf2157) family"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13380"/>
    <dbReference type="HOGENOM" id="CLU_055073_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-849-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018677">
        <property type="entry name" value="DUF2157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09925">
        <property type="entry name" value="DUF2157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2157" evidence="2">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="393" mass="43498" checksum="F731F2AE9A5FA447" modified="2010-05-18" version="1">MTSGDEKRLVSRGNMSFLLREAEVWRELGLISAEQADGIRGLYSARRGRLQNALLGLGGTLVGLGVLSFVAANWLDMSRLLRTFLILAGYAASLVASWGCRERFPRTSRAFLLVGSFIYGGGIFLMGQMFHQGGEWRSAVGWWIVGLIPTAGLFRDRWQAVLLQGLTALYLLFNPLFHPGRVWNVVTWGSTPLWDCLEPFLRNPDELLILAALWGLWRLCGGRTVFRLNALLSLLLLGERFQEGFDDEIALLALALVGLALSLLAPRREDRPLRSDLADLGLLTAGAFGLLLTWSDLWAWTGQAQFAAVLALVDAAVVAVLMLLHLGRRRGISVFFLLLLIARYFFDNFLRFTSKAWGFSIAGSALLALGFLLEQRLKRGEDNPEKKGGDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A5</accession>
    <name>D4M9A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
            <ecNumber evidence="3">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_13590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.180" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13590"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.592"/>
    <dbReference type="HOGENOM" id="CLU_039592_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-861-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="253"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="357" mass="37649" checksum="D14BD194E556D1DD" modified="2010-05-18" version="1">MKFCTLSGVKIGGVAACVPRDRVDNGTAGAELFGSRLADTIRVTGIRERRVAPPGVTSLDLSVAAGKRLLDAAALDPATVGGVIFVTQTPDHDMPNNSSRAAHLLGLPKDCSAVDTNFGCSGYVYGLWLAGLMARSLAAPVLLLDGETQSRCTSPRDRSTALIFGDAGSATLVLPDEGAAPWHFGFLTDGSKHEVLIIPEGRSRQPFNERSLEYREWPDGSVRRPIDIRMDGMAVFDFVVRNVPGCLKALLSGAGCSASEVDLLLLHQANLFMIQQTAKLLNVPLERMPVSLDRYGNSSSATIPVTVCSEAAQQVAGRANRALLAGFGAGLSIAAALIDLGPCVCPPLIEYDEGSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C2</accession>
    <name>D4M9C2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_13860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.623"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-878-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="399" mass="42895" checksum="A26E88C2E5F58C26" modified="2010-05-18" version="1">MEKRELVIIGAGPAGMSAAIYGRRAGLDVLLLERGRTGGQINITDEIENYPGVPHATGPEVGEMLHQHALKFNTDIRTVDDSKVELRGDKKIVVTKKGDETNEIEAEAIIVATGAHFRRLGCEGEAEHIGQGVSFCAVCDGAFFEDLEVAVVGGGNTAVEEGAYLTKFASKVYIIHRRDEFRADRAAIAQALSNPKIVPVWNSVVEKIEGDGMVENLVLKNVKTGEVSNLAVSGVFMFVGQAPDDDCVRGLVKAEKGGWIITNDHMETSVEGIFAAGDVRSKYLRQVITAAADGSVAAMAASAYINEQVHLRSTLLEPEHVKAFFYSSIDEKQAKLSNAAEAEAKARDVKIPVIDGYRNSLMADKLEVTAKMPAVVELSKGKVVKVTTVTSEADLKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C7</accession>
    <name>D4M9C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13930"/>
    <dbReference type="HOGENOM" id="CLU_094875_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-883-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="167" mass="17975" checksum="C511E20E558E8E22" modified="2010-05-18" version="1">MPQGRDAVEAVERVRRALDAAGAQDVEIRVVEGSIFTVEDAAATIGVPPEEILKSLVCLVDGEPVLVLMSGSNRIDSRAVARAFGGRRCRMMPADDVYGSYGFRVGGVPPLGYPQPLRAVLDEDLFRYEVVWAAAGTDHAFFPVEPDRLMRLTGGASASVKKDAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D8</accession>
    <name>D4M9D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14280"/>
    <dbReference type="HOGENOM" id="CLU_091970_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-894-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010718">
        <property type="entry name" value="DUF1294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06961">
        <property type="entry name" value="DUF1294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="121" mass="13404" checksum="905E5643235FAFAF" modified="2010-05-18" version="1">MSMRSSPRRFFLAAAAVCIALTALVARRLGSFLSAYPMWLLCCSVSTFLFYGFDKAQSRRGGWRVPEAVLHLLSLAGGFLGALCGRQLFRHKTQKPAFLVVIVLSAALHLTFALWLLTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F9</accession>
    <name>D4M9F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_14690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14690"/>
    <dbReference type="HOGENOM" id="CLU_006325_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-915-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="798"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="871" mass="98495" checksum="A2C3857BB15EB1B3" modified="2010-05-18" version="1">MSEEHFLPPRAGKGVLSRARVNAILEAAKERGGQWIYVGAPGGFGKSLAVSQWLAPQRNKHAWITLDPYDNNEGRFVRKLLGGLAFAQRANRRLAHTVERVRPPFLECLFDALDLLLPNEKKYVLVLDDLHHLRDGAVLRALPLFRKRLPSAFTVCLLSRDEPPDVFLDAILKGDMTVLDARDLAFDEEELRRLLSRNGLSASQAPDLLRRTAGWPIAVRALLMGRETPEEAEKKRKMSPDEVLHGEELLRRYLDVHVWSGWGDRVQDFLMQASLPALLDGRLCRRLTGRQDSAEILESLSRNLAFVSRLGDGRYRLHDLFRDFLREKLAESPRAGEVHALEKKVADALFEEEDYYAAAAHYIRCSDSRGLSDCCAAFRRIAASSSIEDRIAFFKEYVIGGREELRKDLFEGNLPIMAQCAFVYYVEGDARQFLRLMDKIERELKGRSPKDDSCKKVDEDALQFFWVLRALDFRRPLDRYTDEFLAGRKDLEPLLAGGRLRVGTFTAAMPMLHRSLMDQSDLARGRSLYAQAERRRKAFTSFLGNEHLVILECHLAGILYESGRLPEACFRALKAQEMMETTPCRAEVRFSADLILSAILRGMGRRDEATRIEAETERRIEREGLLPLRPSLRTWRYASRIAGGDGTAAREWLDTYAPPLADRLPLYRMHQHFVTVRALLAVREDALAVLFGEKLLKLGMDFRRQLDVIEASLLLSIAHRNLGNRKKSLFYIERALKIAALCNFSRLFIDDAPALAPILDALLRAFKTRKALWIDFAVRVRAAMAGTDTASPPPSKAEAETVPLLNGRQVRILELLERNASYGEIAKDLGIAHSTAKYHVLRLYRALGASSAAEALARAGCSRPQREDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G0</accession>
    <name>D4M9G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_14720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14720"/>
    <dbReference type="HOGENOM" id="CLU_3356350_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-916-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="36" mass="3883" checksum="BBAF8C0EB6A6AD48" modified="2010-05-18" version="1">MRTMLVSIFLFLAFIFCPVHAEGKDLPTLVSLSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G5</accession>
    <name>D4M9G5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="9" type="ORF">SY1_14800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14800"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.717"/>
    <dbReference type="HOGENOM" id="CLU_034547_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="304"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="372" mass="38711" checksum="70A44F1ACB487055" modified="2010-05-18" version="1">MSSEFGINIRFSVFGQSHGRAIGVLIDGLPAGEPIDMEELAAFMERRRPGKSRLSTARNEADQPLILSGVREGRTCGSPLCAMIENADARSEDYGKLSDTPRPGHADYTAWAKWDGAADMRGGGHFSGRLTAPLCIAGGIAKQILSRRGIWVGAHLAEAAGQTDAPLPLRPSAALLAAVAGREVPVLDEGAGARMKEAILKAADEGDSVGGIVECAAIGLPAGLGEPMFGGVENRLAAALFGIPAVKGVEFGAGFAAARMRGSQDNDPFEVGEGGKIRTTSNNAGGILGGITTGMPLILRAAVKPTPSIFQPQRTVSLSRREVAELRIAGRHDPCIAHRAVPVIEAVTACVLLDLLHDKPPVLRPGAADDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H6</accession>
    <name>D4M9H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium ion-translocating decarboxylase, beta subunit</fullName>
            <ecNumber evidence="9">4.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_14950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.754"/>
    <dbReference type="HOGENOM" id="CLU_036168_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-932-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="378" mass="39940" checksum="F065A27837D1F868" modified="2010-05-18" version="1">MNLLLEGLMAVTAKQAAMYAVGGALIWLAIKKEYEPTLLLPLGFGAILVNLPLSGVVNQSMAGIGETAGIIQWLFETTISASEALPILLFIGIGAMIDFGPLLAQPVLFLFGAAAQFGIFVAISLATLLGFDLKDAASIGIIGAADGPTSILVAQIMRSNYIGAIAVAAYSYMALVPIIQPLAIRLVTTKKERRIRMAYTPGSVTRRTRILFPIFVTFIVGLIAPASVALVGFLMFGNLVRECGVLNTLSRTAQDEFSNLITLLLGITISFSMKAEAFVRTDTLLILLIGLAAFVFDTIGGVVFAKVLNLFLKEKVNPMIGAAGISAFPMSSRVVQRMAAEEEKGNILLMHAVGANVSGQIASVVAGGLVISLVTQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M6</accession>
    <name>D4M9M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15840"/>
    <dbReference type="HOGENOM" id="CLU_1793669_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-983-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="144" mass="15754" checksum="74F511CC17A07921" modified="2010-05-18" version="1">MGMCRCPAPKTMSGIDLDTLKTLKLDELREARIREIETGRAEIETRVGKVLFWTARDAAADLGFYVQEIALAMASGQQPQSIVRKWKTAGGVMDLPGDVAIHIGKSLADWNQVRFDREAALAAKVAAAKTPEAVQAITWNTEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N9</accession>
    <name>D4M9N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage capsid family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15980"/>
    <dbReference type="HOGENOM" id="CLU_887832_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-996-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
        <property type="entry name" value="Phage_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="313" mass="35197" checksum="974465D0886B0870" modified="2010-05-18" version="1">MPDKSFKAMMEEFRKAGEFTPEMVNIGGVVRPEETDRFIDLVVKGNPILSRVTVDRARKLTKDVNVWELLRGVLQRVPQGTKPDKFTSFKNVGKKLEMKDAQLFAHIPMDYLRDNQHRPGLESMVGSRLAETYGNDVTLLAFTGTADDFAGKAFDKLNKGWPQLLKDASDSHKVDVSDHTGGTPAAVNWEGLFSAMVEQLPDVYKGEKTVFLMSRGDAELYQRQIGQMVGGLGHLLAKQNLTYLGYEIVSLNEMPRGHVIFTPLPNLVYGVNTSMERYREYSGEERCIKYTFDSSFDFQVAVDDAAVIAWDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R0</accession>
    <name>D4M9R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16290"/>
    <dbReference type="HOGENOM" id="CLU_214773_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1017-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="47" mass="5689" checksum="07967DA372AEE90B" modified="2010-05-18" version="1">MTLFYRGILALMTILVLRSMFRERSFWRQFADALVLIPMILRILMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R2</accession>
    <name>D4M9R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_16320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16320"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.902"/>
    <dbReference type="HOGENOM" id="CLU_060714_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1019-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061855" evidence="2">
        <location>
            <begin position="33"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="375" mass="41015" checksum="7DD6F83BB3F54070" modified="2010-05-18" version="1">MSFMSYAKLRRAAALAALMALCLVRAPAGAEAAFFRPDVRPGYGVTKIGWLSDYCAPLKGTNLDAPVYFMEGAKPGATMLILGGTHPREIAGHTAALVAVENARVLEGRLIVVPALNASGYGLHDKATNLPRSHRIETRSGARLLPLGDRRVDVVDQGQPDPDQYRHQSGEVIPGSKGGDGAETRNINRAYPGLPDGTPTQQVAYAVVQLVRSEDVVLEVDMHEADTPSWCLDPRTGETRQGGRLAYMLICNPRPEAMEIGAEVVVNVGDAVGFPLKIEQSNRKFRGLSHLEIGDATPCLSFLFETPNPGQDDWREAPDIIRDVRFPLKHRVGLQQQVFQELVNVYNAGHDRHLVIEGLPDYRTLMEQDVGAWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T1</accession>
    <name>D4M9T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16640"/>
    <dbReference type="HOGENOM" id="CLU_1862266_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1038-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061222" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="137" mass="14365" checksum="E7E5BB5DBC4AF964" modified="2010-05-18" version="1">MRRSLCALALVLVVAVAAFAARQDFQRFSVDVPDGWSARDMGNGTVAILADDRSAAVSVTVNSLGTSTLEETAQAMAKALGGTDPTVDEDGDCRFTFWNGGVETQAYLTGGEDEYMMLAVTGQSDALAGILGTIELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U3</accession>
    <name>D4M9U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17030"/>
    <dbReference type="HOGENOM" id="CLU_028518_8_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1049-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="47" mass="5337" checksum="1D3D9559F0457EC0" modified="2010-05-18" version="1">MLSGGRQYIRDFPHMTLYPGLAIMFTILALNFLGDGLRDALDPKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W3</accession>
    <name>D4M9W3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="12">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SY1_17340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="12"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.999"/>
    <dbReference type="HOGENOM" id="CLU_089926_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1071-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBL28658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="180" mass="18935" checksum="161E8E47B5723E4D" modified="2010-05-18" version="1">MPALTSEGLEAELRLAGIVEDSIVDGPGLRLAVFVQGCPHGCPGCHNPEAQPFEGGRTIRSGEVLARLTANPLLDGLSLSGGEPFCQAAALAPLAAAARARGYHVMAWTGCTLEALLRAGRPDWEALLRALDVLVDGPFIQARRSLALAWRGSDNQRVLNVPRSLALGRAAPAEELLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y0</accession>
    <name>D4M9Y0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR-associated endoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_17660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17660"/>
    <dbReference type="HOGENOM" id="CLU_089858_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1088-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005054">
        <property type="entry name" value="PF1131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005054-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005054-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="258" mass="28713" checksum="FB1C06458DE830F7" modified="2010-05-18" version="1">MEGGISVHITLWFEAPDRGAEDAFIRVPRSNLHLFQSLIYSVLPPDRAAFLHDEGYRVYGRRMKLFAMSWPIAARMPSFEAEAVRFPLPVRLVISTPVTDTMDGVAGGALAARELRIGNNVVLCSRVLAEQQWAKGESLTVRTLSPISCYSQTEREGRPYTVYLAPEDPAFAVSVHNNLLRKFRALYPDREPPSGDVSVKPLGKVRERAALFSPKTRFPIKGWDGRFRLEGPRELLQVALDCGLGAKNSAGWGCVTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y1</accession>
    <name>D4M9Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Csh2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17690"/>
    <dbReference type="HOGENOM" id="CLU_071770_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1089-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013419">
        <property type="entry name" value="CRISPR-assoc_prot_Csh2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02590">
        <property type="entry name" value="cas_Csh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01595">
        <property type="entry name" value="cas_CT1132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="302" mass="33459" checksum="C3F49030C3FBFF3D" modified="2010-05-18" version="1">MSFEQRREFLFVYSVKDANPNGDPLNANHPRFDDDSGQILVSDVRVKRTVRDQWLIEGRDVFVDGETKTLKSRVAELKEKLGVTTGKEALSRCIDTRLFGVTFALGSESFAWTGPVQFKWGRSLHRAAVETVQGTAAFATKEGSEQRSFRSEYIVPFVLIADYAIANQYASLTTGATDEDLEALFSALWKGTANLITRSKVGHMPRFLLEVRYAKGFDGIIGAMDEKVRLLGADGHSLSADEQLALRSCDEALLDITALSSALSRVSQDVERVRILHEMDLKVKGLEELKALLGGKLALEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y7</accession>
    <name>D4M9Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_17800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17800"/>
    <dbReference type="HOGENOM" id="CLU_083287_14_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1095-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="242" mass="28046" checksum="022D18C74E2B2D07" modified="2010-05-18" version="1">MDDVCRDIYEKLSFVQWLLRRLQMLRHTEYGPFSDIHYGQGRVLAFLKVQPKIATKDLAYLLGLRQQSLNELLNRLEQGGYVERKPSEEDRRVMIVHLTDKGKELRQPESDWASVFGCLSGEELSALSRYLDRIIDSLESQVEIPFEEHLSAWMEQARERMGDERFEEAVRQSGFGVRGGVKMFRWSRRRGEDPRLGCDLRGPAPKDLPGAERFSPDYDGPVPEGRGRCPWQRQKESGDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA11</accession>
    <name>D4MA11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type oligopeptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_18480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1109"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1119-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="12"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="305" mass="33294" checksum="BFF5D45328B8C994" modified="2010-05-18" version="1">MSGAKAAPETFLDIRGLKKYFSVHGGLLHAVDDVSLSIARGCTLGLVGESGCGKSTLGRVVIGLIEATDGEVLFDGQDSLKFTGAKRSEFRRRAQIVFQDPFSSLNPRMSVSQLIAEPLVINRACPHRELDARVKKLMDTVGLASRLITSFPHELDGGRRQRIGIARALALDPDFIVLDEPVSALDVCIQAQVLNLLEELKKERGYTYLFISHNLSVVRYVSDEVAVMYLGQVVEKADNTTLFKNPVHPYTQALLSAVPTARLSGRRQRIILEGDVPSPINPPAPAASWGAAPTVRTSAWRGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA14</accession>
    <name>D4MA14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
            <ecNumber evidence="1">3.5.1.90</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_18520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.90" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18520"/>
    <dbReference type="HOGENOM" id="CLU_056334_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1122-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043756">
        <property type="term" value="F:adenosylcobinamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="380" mass="39417" checksum="588FAA50B225CCC8" modified="2010-05-18" version="1">MKVWSSACGDVARRLGEAGRAVVLAFGGPRRVLSTSPFNGGLRTDLRQAFNYSYSIKGGEYCTMRAPTYAEHLALIAREIGLNPAVSVGLSTSAKMGHLAILEDGWGSAEVAALVTAGLDVNAGRSGDPADWDEEAERRSAPPTGTVNVILHFSCDLSEGALTRALITLTEAKAAALQELAVPSRYSHGIATGSGTDGAIVVANAASSLRLTDTGNHSKLGSAVGRVVKAAVKEALRLQSGLTPQSQHGILRRTERFGVTEESLWERYRHGGGRLDRARFAAALAGLDARDGLLASVSLIVHLMDQAEWGLLYPDEALSAALRLLAAMGVCVAPSGSVHDAHDAEEAVAFIAGAVSDALVRLAVDSGNSCEGPLAGNGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA18</accession>
    <name>D4MA18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">McrBC 5-methylcytosine restriction system component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_18570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32615">
        <property type="entry name" value="SbaSGP1McrBCP"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1117"/>
    <dbReference type="HOGENOM" id="CLU_065564_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1126-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019292">
        <property type="entry name" value="McrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014407">
        <property type="entry name" value="McrC_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38733">
        <property type="entry name" value="PTHR38733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10117">
        <property type="entry name" value="McrBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003109">
        <property type="entry name" value="McrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="351" mass="40801" checksum="77F36A0094569640" modified="2010-05-18" version="1">MIKDRSIFIKNIYYMLSYAFTALNQGGYEDVATEEFENIHNLFAAVLAKGIGRQLKQGLYREYLNRKEDVAVVRGKIDMPRTIQNRLARKCMLTCEYDELSENNLLNQILKTTVMLLLRHTKVDQEYKSNLKKEMLFFSKVSTIDPTTIRWSAIRFQRNNNTYRMLIGLCQLIIDGMLLTTDSGEYKLAAFVDEQRMNRLYEKFILEYYVRECPQVTVTASQIPWALDDGNGTMLPIMQSDIMLIRGSEVLIIDAKYYRRTTQTQYDVHTLHSNNLYQIFTYVKNTDTNFGAQPHKVSGMLLYAATDEAIQPNNVYQMSGNRISVKTLDLNQKFSQIAAQLNAIMEEHFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA25</accession>
    <name>D4MA25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1129"/>
    <dbReference type="HOGENOM" id="CLU_737229_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1133-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="375" mass="38516" checksum="A9F6FD33B324376E" modified="2010-05-18" version="1">MAKRVNQGGFVSVLLVLAAAVVLGTDLTADAAEFGFHYKSSAGQEGYVTSVKDTTTEVPALKEMFLGEELDFTTSDDYSGVWDKVLHMDALLEEKIEYVNLGMGTGKAHFLKTVKPGETGRLLLSPSATTGEKTSFDLKGITAKSPVSMDLDKAALAIDTSKASEDALTLTLKGKAGAVDKDLKVAGVTFDFDPAKLDAAKLSLTWDGAGKKIQAKALDAVYSVAGVPVKAEVGMTFTGEDGQNWALSEDVNFTITSGPGHPATVTVTATAGPGGTIAPKGAVTVAYGADQAFTISPDINYKIKDVKVNGASIGAVATHTMKNVTSDGTIEATFEKTSGGGGGSSGGGGGGGCSTGYAFLPLLGLLPLALKMKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA42</accession>
    <name>D4MA42_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ORF">SY1_18960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18960"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1157"/>
    <dbReference type="HOGENOM" id="CLU_052779_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="336" mass="37196" checksum="71762C4FAF171865" modified="2010-05-18" version="1">MTRTIYLTQDNGVLGRNGEGFSWRRSRKEPPEKIPNTNLGDVVVVGNGSITTPALHLLMDRNIPVHFVSSGGRYKGSLTSGMGHGYELRRAQYDSALSEDRSLDFARSFVVGKVLNQRQTLTRFMYRRPGGGEVFEDAARELAILAREASGSSCLEALRGTEGNAARIYFSVLGNALIAPWRFDGRTRRPPRDPVNALLSFAYTLLLGRVTTAVVTVGLDPCVGWLHPAYRGRPSASLDLMEEFRSAVVDRLVISILNQGFLSENHFSAGEGGGVRMAQSAREKLMRLFKERLRTEVVNSSNNHSSSYENHIFAQAQSLARSIRDGDSYLPFVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA56</accession>
    <name>D4MA56_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_19160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19160"/>
    <dbReference type="HOGENOM" id="CLU_014823_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1164-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061045" description="Dipeptidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="544" mass="61450" checksum="270679998CA2D534" modified="2010-05-18" version="1">MRLIKVLVLGVVLCLTMAAAALACTSVMVGKKATADGSVLVSYTCDGWYDHRLKVVPGGKHKKGEMVPVYHNICYQTRPGKELKKVGEIPQAETTYTYFHVGYPIMNEKSVVMGEYTWGGREESECQNAIFMIEQLQVLGLQRGATAREVIEVMGELAEKYGYADGGEALTVGDKNEIWLFEITGPGPLWTPESGKPGAVWAAVRCPDDSYAMGSNRSRIAEIDFDDKDNFMYSSNVKTVAQDMGWWKEGEPFVFHKLYNPEPYGSPYYQQRREWRAYNLLTPSVKLAEDAAEQYPLFQKPDKPVTPQDLMALCRDVLEGTRFDMTKGLAAGPFGTPTRYAVTKDMKPEDRKGNDWNRSISLFRCSYSFVGQVRDNLPEPLAAVAWFGEDQPITTCYMPIYAGTKEVPESYNTGERVKFDPKSTWWAFNFVGNWADLNFAAMIGDVRAEQKRLEGKFFAEQADFEKKAAELYKKDPKKASEMITKHVDDNMKLVDRDWWALAWTLVGKYNDGYRITADTMEPLGYPTDWLKAVGFGDQDAEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA57</accession>
    <name>D4MA57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_19170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19170"/>
    <dbReference type="HOGENOM" id="CLU_060714_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1165-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061566" evidence="5">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="388" mass="42906" checksum="FCD78B446D3C60C1" modified="2010-05-18" version="1">MERLKWIKAMAAVLCTAAAAWSGAEFYAMRHYKEPVALGPGVTQVQKLSLYEPSLQGTANDCNLYFLDSGKPGGTVLLLGGTHPEEPAANLAAQVVVENARPEAGRLIVVTRANTSGSLYSRNGEAYPSFYDIETPWGKKTWRLGDRSGSPLDSWPDPEVYVHYPSRQMLAYMDIRNLNRCWPGRPNGLLVERTTYGLAQMIRAESVDVVVDLHEAELEYSVENTIVAHEKAQEIAAMASMLLTGTEFEVPIGMEFSPKTLHGLSHREVGDHTQAMSMLYEVAEPLLDRIRGVTDQKLVLEGKDEFVVEAGKHKLLYAPIDENGWHIDVRVGRHLSTFLQCLDIFSSMTPGREIVLTGVPRYAEVKEKGVGSFFHDPTKAPLGGVAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA68</accession>
    <name>D4MA68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction modification DNA specificity domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_19300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32619">
        <property type="entry name" value="S.SbaSGP1ORF19290P"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19300"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1195"/>
    <dbReference type="HOGENOM" id="CLU_2824861_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1177-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="66" mass="7490" checksum="DB49516722CBDE01" modified="2010-05-18" version="1">MCKAAIGQANINAQELQSIGIYIPPIELQKEFVAFKEQLDKSKIAVQKALDEAQLLFDSLMQTYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA70</accession>
    <name>D4MA70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_19320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19320"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1197"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1179-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="294" mass="33357" checksum="AC0365B38B162960" modified="2010-05-18" version="1">MDMNLQKYLAFVKTVEYGSFTKAAEALSYSQSGVSRMISDLEQEWKVSLLERSKGGVRLTSDGMRLLPCAEELCRAFQKLETQVDSLNGLQTGLIRIGTFSSVATHWLPPIIKEFQKDCPNIDYELLLGDYAEIEEWVLRGRVDCGFLRLPAHPKLETIFLKQDQFMAVIPTDHPMADCEVFPVQALCDLPFMLLEKGARAEISGIFERFGLKPNVHFTTWDDYAIMSMVESGLGISVLPSLILKRIPYKILIKPLDVEVYRNIGVALRSRQTASPAVKRFLEYLNFRHQAEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA88</accession>
    <name>D4MA88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial nucleoid protein Hbs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19560"/>
    <dbReference type="HOGENOM" id="CLU_105066_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1197-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="100" mass="11015" checksum="0355FC47F9CECBB5" modified="2010-05-18" version="1">MTKAELIDAIAEKLLLKKKDVVPVVEEVFASIEGALSRGEKCTFVGFGVFEVKERAAREGRNPQDPTKVVKIPAKKVPVFRPGKDLKEKVLAIKGKKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB4</accession>
    <name>D4MAB4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LpxI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20160"/>
    <dbReference type="HOGENOM" id="CLU_1934958_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1222-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041255">
        <property type="entry name" value="LpxI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17930">
        <property type="entry name" value="LpxI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LpxI_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="130" mass="14173" checksum="114B35C4AA99878B" modified="2010-05-18" version="1">MTDPIAGAPIALIAGEGALPEAIARKLAEAGEAPLVLAVRDDLEALAPFARRLVRLRWPSLGRGVREMRRFGAGRVIMAGWIPKRVIYFLPLLFDRLSRSVLAGSLMDDHSLLGAVVRALEREGFSVIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH3</accession>
    <name>D4MAH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engB</name>
        <name evidence="10" type="ORF">SY1_21230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21230"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1382"/>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="195" mass="22150" checksum="C3D02850DFF01841" modified="2010-05-18" version="1">MRVSLEATCFTPQQLPPEECPEVVIAGRSNVGKSSLINAFLGIRLAHVGATPGKTRSINFYRVEEDERPFRLVDLPGYGYASRSKAEKDAWLRLISAYVEGRAALRLVCHLVDFRHGLLANDLELQEWLVRCGRDILVVFTKADKLARGRWKDRVRQYVARGLHSVDLPIVTSAEKRVGVEELRSFIRSFLERND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI0</accession>
    <name>D4MAI0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bifunctional enzyme IspD/IspF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
                <ecNumber evidence="13">2.7.7.60</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="13">MEP cytidylyltransferase</fullName>
                <shortName evidence="13">MCT</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
                <shortName evidence="13">MECDP-synthase</shortName>
                <shortName evidence="13">MECPP-synthase</shortName>
                <shortName evidence="13">MECPS</shortName>
                <ecNumber evidence="13">4.6.1.12</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ispDF</name>
        <name evidence="15" type="ORF">SY1_21340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the IspF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="13"/>
    <dbReference type="EC" id="4.6.1.12" evidence="13"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1394"/>
    <dbReference type="HOGENOM" id="CLU_042800_2_5_0"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01520">
        <property type="entry name" value="IspDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026596">
        <property type="entry name" value="IspD/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="11 13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YgbB" evidence="14">
        <location>
            <begin position="224"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" evidence="13">
        <location>
            <begin position="225"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="13">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="13">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="13">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="13">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBL28875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="385" mass="41393" checksum="4CD0EAD75095F74D" modified="2010-05-18" version="1">MKRFSFVIVAGGSGSRMGGERKQFRLLGGRPMWRWSAEMAASMAEEGIGEIVLVLPRGEVTPPPWRQSARIPLRLAGGGASRAESVLSGLNAASFDYVMVHDAARPFISISLMRRLMEETSEGVGAVPVLPASDAIKRIDGERVEAVDRDGLYMTQTPQSFYRPTLMAALRERGPAAKDEAEAWLASGLELHCVEGERLNFKVTWPDDLHIAERIAEGRRAPTVRTGLGYDVHRLVPERPLILGGVLIEDSPLGLLGHSDADLLAHAVADAILGAAGLPDVGTLFPASSEEYRDADSMELLKTAVDLVVEAGWTIAWVDAVVQAQVPRLSPHLVEMRKRLSAILNPDLPNCVSLKAKSAEGTGDPGLGGSMTCWASATLYGDGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI7</accession>
    <name>D4MAI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_21550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21550"/>
    <dbReference type="HOGENOM" id="CLU_030024_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1296-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="59"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="300" mass="33710" checksum="F685F1BE58FC49A4" modified="2010-05-18" version="1">MLHRIGEKDPMRLPPNEDMKVSPAFLERFIVDAKCKGFTFLSVSQLHAALTGEGPWPSRSLVLALDDGYRDNLTEGLSLFERHGVPFTIYLSTAFIGSSCVPWWYGLEGLLTSRPALLWEGRTWDVRSVPEKSRLFMQIRGQALLAEQGAEAYVLDLCRDNDYDCGSADGLFLTWDEVRALQAHPLAELGNHGHRHLNLQTVSREAVYREFSLAREEMARQTGCVPAHYAYAYGLFGDEALSVVREMGALTCMTTAPGRVSRGDREKLWALPRFMLYEGMSVDDLLAQSAYVSLRRSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK5</accession>
    <name>D4MAK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lauroyl/myristoyl acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_21830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21830"/>
    <dbReference type="HOGENOM" id="CLU_049421_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1314-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="309" mass="34092" checksum="7CCC794A526328A1" modified="2010-05-18" version="1">MSAAACAVRAFQAVADAGWRGRMVYGVLYGLLKLVQPRRERIDANLRLVWPERDAAWRRAFRARVYQNLAWTVTEVLALQRDPGQASSWISGVEGRSILDELAEGGQGAILLTGHFGNWELLGTWYAQVLKAKGRQLYAVFQEIHDRDLSGVLKGFRERGGISVLPKEMSVLEMAHRLRAGAHIAILADVSWLEGALTLPFMGHECTNSPGPAILAMLASVPIVPLGIYRRGPFEHGVRVFPPLSIPGQGSRAERIGGGTLAINRALEAIIAPRPELWFWLHDRWKSRPLSRQTVVKDGAAEKSPVCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAM0</accession>
    <name>D4MAM0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SY1_22100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22100"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1460"/>
    <dbReference type="HOGENOM" id="CLU_135056_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1329-MON"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBL28915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="126" mass="13822" checksum="85C1B68EC6029988" modified="2010-05-18" version="1">MHLILGGRHMGKRTYADSLYGPALSPCDLASADLALLPAADRVLNLQEGVRRLLLAGTDAGEFFRAHLEDLRTCVLIGSEVGSGVVPMDPIERRWRDETGLLYQLLAREAAIVDRVWCGLPLRLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN7</accession>
    <name>D4MAN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized phage-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22340"/>
    <dbReference type="HOGENOM" id="CLU_110683_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1346-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025272">
        <property type="entry name" value="SocA_Panacea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13274">
        <property type="entry name" value="DUF4065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4065" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="139" mass="15680" checksum="ED51AB38DD331EF8" modified="2010-05-18" version="1">MIALDLAKYIVTKCVKDSCAISNLQLQKILYFIQKDFLCRGEFAFLDAIEAWPFGPVVPAVYYHFCIFGSMSITTAYEGITIEAKDRARIDPIVEAKRVLPPWDLVEDTHRKNGAWDQIYQDGAGNRKVIPPDLIKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAP7</accession>
    <name>D4MAP7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SY1_22540</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22540"/>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1358-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="4"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="339"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="311"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBL28942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="461" mass="48207" checksum="4D44E86B85C0FA98" modified="2010-05-18" version="1">MSSKRIVIIGAGPGGYVAAIHAAHLGASVTLIEKKTIGGTCLNVGCIPTKVLLHTAELLTELKSEAKRIGVLVEGTRLDWDALMKRKTLTVSRLVKGTLSLVQGNGIEYIEGAAAIRDPHTVEVNGRAIQADAIVIATGSVPDVPDVPGYDLEGVITSDEALSLPAPPASMVVSGGGIIGMEFAAAYAAFGTKVTVAVTSPEILRNLDTDIALILRKNLEKRGVSFRTGASITRVTRSGEGLKIELTTPEGQAELEAEKLLVAKGRKPYTEGLGLEALGIEMKRGRIVTDAHMETNVKGIYAIGDCVNAYMLAHVASREGEVAVENVMGHAVDMDYTTTPGAIYTSPEIATVGLSEKDAAKRGLKVKVGSFPLMLNGKSMITGDTSGVIKIIADDETRQILGVEMVGGPATDMIAEGALALHFKATPEDLLNTIHAHPTVAEAVAEAAGNVFARGIHTPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR1</accession>
    <name>D4MAR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22730"/>
    <dbReference type="HOGENOM" id="CLU_090389_20_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1372-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="92" mass="10868" checksum="E7E54F2616DE54AA" modified="2010-05-18" version="1">MKKVTFFYLEACPYCKNARRAMDELKAGDARYRAIEMDWVEESERPEVAEKYDYYSVPTMFIGSEKLYEAHKGEEYEECKTNVKRVFEAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR2</accession>
    <name>D4MAR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22750"/>
    <dbReference type="HOGENOM" id="CLU_116596_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1373-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="200" mass="22051" checksum="5748052E85424BD7" modified="2010-05-18" version="1">MICQHCGAPLEAGIELCSFCGSPTPYDEMLLDEKIQRKQALQRKKKLAGLAAIKHVSDLSLPFLWIATMGIYSPVWYLTRARSLNRMNSPKKLPAFATIVQLVLYLGALSLPGAWEGIGVDAETASAYNHCVFGASFFLSIWLAFRVKDILQAHAAQYLDKAVVVHTIAPSAALLVVFGPLYLQTQINKMIFMELLKPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS0</accession>
    <name>D4MAS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase CsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22850"/>
    <dbReference type="HOGENOM" id="CLU_039510_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1381-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019896">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase_CsaB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03609">
        <property type="entry name" value="S_layer_CsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="17"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="333" mass="35696" checksum="19322C112F4E7ACE" modified="2010-05-18" version="1">MSRRYRVALAGYYGFGNLGDELLLRASLEALERCGVGRDRVVVLSSVPAETSCILGADSVDRWNLSAVRGVLRSSDTLLLGGGGLFQDSTSLLSCLWYWGLVRLACLCGARPWALGQSIGPLRRHAARWLTRTALASCTVLQLRDGPSMEWARRLGVRATPGADLSLALEMPKNAAPAGRERLLVNLRPVAGPQRFVELAASCVDAFDGERVGVAMSPEDYELLEGARRMGRLRIERTVLAESASDVAPLWSAATGAVGMRLHFAVLSAIYGTPLALLSYDPKTAAFAEWVGLSGVGNPAEGAVKLVRPRLPIAPEKVREDVDALCRAALSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT1</accession>
    <name>D4MAT1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="3" type="ORF">SY1_23030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23030"/>
    <dbReference type="HOGENOM" id="CLU_089475_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1392-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="129" mass="14307" checksum="05B7303308331FFB" modified="2010-05-18" version="1">MARINKQLQREISLLLESRIKKEAVKDAIITGVDCSRDLDVAKVFFTALTPERRRELREELASVRGALRTLLGQVLKLRRIPSLDFVPDESADYGERIDGILNRLGMDSAVAGSEEPDTAEEGAGEPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT6</accession>
    <name>D4MAT6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_23160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23160"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1560"/>
    <dbReference type="HOGENOM" id="CLU_004585_5_8_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1397-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="293"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="682" mass="76434" checksum="098E21189950A9F8" modified="2010-05-18" version="1">MLENDILERLSPRQREAVTYVDGPLLILAGAGSGKTRVLTHKVAWLIAEGLARPWEITAVTFTNKAAGEMRERVSALVPDGADKVWVSTFHAFGLRFLFRNPEAVERLTGLRTGFAVLDRGDSRSLVGQIMERLGVNTKDTAPASVLDAISRDWAAWAPGPREPLLEGLYLDIANEYRRALRERNAVDFDDLMVLPLQVLTQDRELREREQARIRWLLVDEFQDVNRPQYLLLRNLVGPDCLLNVVGDPDQSIYGWRGADIGMILNFERDFRGEEGHADAKTIVLDENYRSTGNILAASNALIRNNSTRMKKDLRTSRGMGEKVYTLLANSDLQEADFITAEIARLKAHHGYDYGNIALLYRQNAMSRLYEQKFLELGIPYRIVRGVAFYERREVRDVLALLKLALNPNDLTSFERAAEFAVKGMGPKRREDWTSWLASGAVPTSPASDFWGAAAKGAWPVRGQVGAAAAEFAAHMARLLAVSERGIGPAVDYVLNQMGYEELLRSKEPESWEERYDNVMELRSVVPEGGLSEALAEAALFTDADRQDDSGNAVGLLTLHAAKGLEFPVVFLVGMEEDVFPSSRAKDQPDQLEEERRLCYVGMTRAEERLYLTAARSRRLYGTTLSKGFSRFIYEVPEQYREIDDRAGEGRGWDEGYGGGGRRRSYGGYGKGYRPYGGRWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU6</accession>
    <name>D4MAU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyl-D-aspartate/D-glutamate deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1575"/>
    <dbReference type="HOGENOM" id="CLU_016107_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1407-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023100">
        <property type="entry name" value="D-aminoacylase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="43"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="527" mass="57851" checksum="0F82EF33950B3F42" modified="2010-05-18" version="1">MYDLLIKGGVCYDGTGREGFKADIAIKDGLIAKVGEPDADAAKVIDAKGLAVAPGFIDTHSHSDLVALVEPGITNKTTQGVTTDVIGQDGMSLAPVLPRYVSTWQKTMAGLEGQYPVEWRWESAAEYMKALDAMDLGPNLAYLAPTGNLRMCVMGLSNRKATPSEVSMMKDLLEKCIEAGAVGLSTGLIYPPSSYMEEDEIAQVTSVLAKYDLPFVIHQRSEADTILESMDEVFRISRKSGCPVHFSHFKVCGKKNAHLFDAVMKKLDEGERDIKLSFDQYPYGAGSTTFSVILPPWAHDGGADQCLLRLADEAERQRMKRDIVNGIPGWDNFIDFAGMENILVTFVKTPKNADLVGKNMIEIGEIRGREPLDAAFDLLLQEDLAVGLVDFYGLEEHVRTIMTHHLQNPCTDGILGAQPHPRVYGTFSRILGHYVRELGLMTLPEAIRKMTSRPASIFHLEGRGVLKEGYVADVTVFDPEKVIDKATYTDPMQFSEGIPFVIVGGTSVVEDSQVLKGKAGKVLRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV0</accession>
    <name>D4MAV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_23380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1579"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1411-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="221" mass="25219" checksum="12F27B6D37B0D9C2" modified="2010-05-18" version="1">MPIPQIKPGGSRESARAQVYRQLQDWIVDGTMQPGERISDQDVAEYFSVSRTPVREALQLLSEQGFVRVEPSRGTHVSPLNGDLAYSIYEALSSLSGCAAKLACQKQKKGDIARLRELNGDFERAVAAGEHDRLSNLDNVFHKFILKMADNPYISDAVLNLTMHSNRYENLYFREGTDRMESVREHEALIRALEVRDDEESARAAEENWLGFYRRRLQKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV8</accession>
    <name>D4MAV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_23470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23470"/>
    <dbReference type="HOGENOM" id="CLU_1406958_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1419-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061577" evidence="2">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="193" mass="20586" checksum="543F58DD7E110D6B" modified="2010-05-18" version="1">MKAKKAIITLLVLGSVGLAGAALARGYCGHGRAVAPYCPPAQEGHWGQNPAAGPGCGWQGARPDACWGRQDSSCFGEATDGWCGGPARWGRNGGRGAHRGWVMDLPQELKEKARSLEKLRIDLDYALASTPIDRPKALELYGQIQKLRDELQTAAFTRRLDRIEETAAQRRLNSTVKPGAPAQGTTGDAAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW0</accession>
    <name>D4MAW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23490"/>
    <dbReference type="HOGENOM" id="CLU_1494146_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1421-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061245" evidence="1">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL29005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="180" mass="20487" checksum="C96F839E40D255C8" modified="2010-05-18" version="1">MKRTRTLVLFAAACLAVLAAGAAEALSNSADAFMSLPFGHPFNRTKLRMERSGATAKAQDGDYLSMEGLFEGRPALFVFSFHGRKGLKSKALYLQTVGREEDERLYTVLMQAYNGRFGRTEERPLPNTWAEGKIMLRCTWTPDRWTSVVLTYNPETAVRFPGPSIRDRPIHLEYRYSRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW4</accession>
    <name>D4MAW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein related to glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_23590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23590"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1600"/>
    <dbReference type="HOGENOM" id="CLU_024307_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1425-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="175"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="709" mass="78714" checksum="278DED7BB4411388" modified="2010-05-18" version="1">MVERAREYPTVREIYGSMVFDRRVMKEKLTSGVYEQVVAAMEGRQRLDAAAADVVAMAMRDWAIAQGATHWTHWFQPQTEMTAEKHMAFTLGGADGMPVDVFCGHDLIQGEPDASSFPSAGTRSTFEARGYSAWDISSPAFIVKSPKGGTLCIPCVFLSFDGTPLDFKTPLLRALDALETRSLKLLKLFGQRGVRSVRVTAGAEQEFFLLDRPRAQMRPDIRFCGRTLLGAQPAKDQKLDHHYMGSIPPRVLSYMEDVERDLARIGVSIITRHNEAARCQFEFAHLFSDANTACDQNQILMETMRKLARQHELRLLFHEKPFHGMNGSGKHVNLSLMDSEGRNLLTPSSGQRRNVVFLSFLAAAVLGISKFHILLQATAATAGNLFRLGGHEAPPSITSVYLGSALTDLLKRLNQADASLPERGLMDLGLMKLPSIIPFDNDRNRTSPVAFTGNKFEFRSPGASQSIALPITMFASIWAWGVEQLTGMIEARSVDGRDPMDVALDAVKEAVREGQNVLFEGDAYSPEWHAEAKRRGLLQAETMPEKIDLLLLPENKRMLEDLGVYRGRELEVLHDIRMEEFARGLEIEAAVLYDMLWEGVLPALSKQMVLERSSLAALDGMDFEEGAPWLEYIGNLGRTKAALISDAARLHEMKGRLAGMALRDRADFLAGSVVPLMESIRAQSDAAELTIAADIWPYPIYRNLLSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY5</accession>
    <name>D4MAY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_23980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23980"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1447-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="289" mass="33565" checksum="202BA444AEBCE52B" modified="2010-05-18" version="1">MTLREMHIFIEVCKTGSMTEAGRRLFISQSTVSQVILALEKQYHLKLFERNKKRLIITEQGKIMQNSCIKILSEVEELEYSLSHMGQKHIRVGTTLISSSSVLDQIWSAYHLACPDVRTQIIVEDNESLVYKLQNHDLDVVITEQNVEARDMFCRKFAEDVFVLICAEGNEFFNRDRIQLNELHGKQLITRERGNPTRELIEQVMAEQNILIHLIEFNNIDIIKAEVIKKHGIAIMARRLLVQELQRRLLRAIPIADLKKKRSFYVLSQIHSLSNPIIEQFIKICQSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY6</accession>
    <name>D4MAY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline-glycine betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_24000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1647"/>
    <dbReference type="HOGENOM" id="CLU_010118_6_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1448-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL29031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="526" mass="57967" checksum="6DDD430D8EBE4A98" modified="2010-05-18" version="1">MLEQKEMRVKRTLRKGVFYPSFLFMTLAIIVGILKNDWLKSACRAVFRFSLLNFGWLYQIIAVICLFAIVLVTFGRIGNIRIGGPDAQPKYPFRTWFAMALTGGISVGIVNWGINEPMVYFGNVYGELDTLGIQPQTVEAARFAMGRCFYNWTFVPYAFYCITGLLIAYLFFNKKENFSVVATIKPVIGHWADSPAVASLVDTLCTIGIVLGMACGLGTGLAFVINGFKVAYGMETGTMTWIVLGIITTTIFTGAAYTGLDKGIKKLATLNSKIFYALLIVLFFTGPIVEICKTLPIGLGEWLNNFWLWGLDPIDIGGEALTAWWTLFDWTVWIAYAPVMGLFLAKISYGRTIREFMIINWILPSIFGLVWFSVWGGTALNWQMNGVVDLVSILKENGATAAVWGFLQHLPMNLGIVLIPVVMVTLLLSFSTAADSITHTLASLCVSSDRTSDEAPGSLKLVWGIIIGAVSVIMGAFAGGVRGVDGARQLSAVGAFVVLSVFVLQLCAFLKTFFNREIQGEYRDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ4</accession>
    <name>D4MAZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_24100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24100"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1456-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="23"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL29039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="447" mass="49691" checksum="ACFD8EE2C2EB2EB9" modified="2010-05-18" version="1">MGVQMNLLTYNGLTRIDMKTLQPVCDLAQSYTQESDTVWVFKLREGVLFHNGDKMTADDVMATIQYAKKFPNSKNYTASMQKIEAVDPLTVRITTFAPNPNLLNDLAYHFNFILPKSLIDSGNDFNVNPVGTGPYKFTRWNKGNSIAFEAFDEYFDAERRASIKTLRFVMIPEGTTRTMSLESGEVDFVYDIAPNDIARLLATDGIAVANVTSVENFFLHLNCVSTPFKDVNLRKAIAYAINREEIIAGALSGHGTPSYSCVSMGYKESSLENAYSFNLNKAKEYMGAWGGDPASVTLDVICSNETKKAIATIMQDELSQIGIKVTVNEMDAASYQAAMTTLNLTAAIVSWSPSNAMTYIQRFQTSRRDAVPSSFADPKTDEVLSKINVCMDEKKRTAMIHDAIGLINDMCPFVPIYQVDYFRAHNANLKNVVCSATGYVDFSVMSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB00</accession>
    <name>D4MB00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_24160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.11" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24160"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1658"/>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1462-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL29045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="362" mass="39589" checksum="3418F8D2F4B7A952" modified="2010-05-18" version="1">MEKKFRVGVLGGTGMVGQRFVQLLAAHPWFETAAIAASPQSAGRTYAEAVEGRWLLDGAVPDSARDLVLRDVSDVAGMADRVDFLFSAVNMPSDELRRLEEDYARAETPVVSNNSAHRWTPDVPMIIPEINPTHAEVIEAQRRRLGTSCGFIAVKPNCSIQSYVPALAAWRDLEPLEVVAATYQAISGAGKNFDTWPEMRGNVIPFIEGEEEKSEREPLKVLGRLRGGEIVQADGPRITCHCLRVPVLYGHTAAVLVRFGREPASVDELIALLRDFRGVPQELGLPSAPKQFIHYLEAEDRPQPALDAQCEGGMAISIGRLRRDPLFGWKFVGLSHNTLRGAAGGAVLCAELLASRGYLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB07</accession>
    <name>D4MB07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulator CtsR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_24300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CtsR family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24300"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1670"/>
    <dbReference type="HOGENOM" id="CLU_118139_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1469-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008463">
        <property type="entry name" value="CtsR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041473">
        <property type="entry name" value="CtsR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041908">
        <property type="entry name" value="CtsR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040465">
        <property type="entry name" value="CtsR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041902">
        <property type="entry name" value="CtsR_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40028">
        <property type="entry name" value="PTHR40028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05848">
        <property type="entry name" value="CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17727">
        <property type="entry name" value="CtsR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CtsR" evidence="7">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CtsR_C" evidence="8">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL29052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="159" mass="18528" checksum="CD1A03ECE74BCB23" modified="2010-05-18" version="1">MPNLTLAIEKYIQELFETETEPSVSLRRKELAEFFGCVPSQINYVLRSRFTPERGFLVESQRGGHGYIRILRISCEEPEERLKHVEDIVGDSISEQDCRRLLQSLQERGLITVRERLLIEVALRHADEMGRSDFDLSQHKRSVIQAEMLKRMLRGLMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB08</accession>
    <name>D4MB08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_24310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24310"/>
    <dbReference type="HOGENOM" id="CLU_2023348_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1470-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL29053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="122" mass="13878" checksum="1CFDAFC24B4490E6" modified="2010-05-18" version="1">MMDFLALVFPSEKKWIRLILALIGGGPLMFSSESVWWTVGFLASITFWWFLSLVLEMLGVVEINTANRIAFLSPLAVSLGLWFWMHDLPGIYFFIPAIVLGLGLIMPLSFLMCDPRHPSTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB09</accession>
    <name>D4MB09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_24320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24320"/>
    <dbReference type="HOGENOM" id="CLU_2600973_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1471-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="79" mass="9261" checksum="2500926980097979" modified="2010-05-18" version="1">MAVSYSEIYESKKQAAKRYDEILKGLSKKLGSAVRDDRGFLSWFMEEKKLGIMQLFFHDKEVTGVFVVIKKKDFYNETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6X7</accession>
    <name>D4M6X7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="6" type="ORF">SY1_00120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00120"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2"/>
    <dbReference type="HOGENOM" id="CLU_068508_1_2_0"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="147" mass="15676" checksum="E3491D9371C5A528" modified="2010-05-18" version="1">MAEVQVRIQRFGRAREFPLPAYATEASAGLDLRASEPCVIAPGARALVPTGIRLAIPCGYEAQIRPRSGLALKHGVALPNSPGTIDADYRGEVKVILINLGDEPFVVESGDRIAQMVFAPVTRVAWCEVETLDATERGEGGFGSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6X8</accession>
    <name>D4M6X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Excinuclease ABC, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_00150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.657"/>
    <dbReference type="HOGENOM" id="CLU_014841_3_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-3-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="3">
        <location>
            <begin position="46"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="2">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="4">
        <location>
            <begin position="273"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="523" mass="59447" checksum="E7CFEA5B0A3148DE" modified="2010-05-18" version="1">MADGPAPQQEGARGERNVARPGAKNSARQGGAIKEKVAAILRSLPERPGVYIMRDAEGTVIYVGKAIKLRRRVSSYFRHSNFASPRLRKLVSLVEDISVIRTETEAEALIVEARLIRRYSPFFNVDLKMNDRYPYIRVTDEAFPRLEITRVKRDDGAVYLGPFVSAGNIRSLMRLAERYFPLRVCRADLKPDPGKRPCIEYSLGHSMGACAGLCTQAEYRERVGDVILLLEGNTRELIERLHRRMDAAARRMDFEEAAHCRDTMRALWRISRQRVSSALQEDLDSETWHVLNQTQRAFGLRTIPWRMDAFDISHTAGHDTYGCCVVFEQGRPNPSLYRRFRIRGLAEGEVDDFASIEETVRRRYRHVLDQSEPMPQMALIDGGPVQLEFAMRALAELEMELPLVALAEREELLFLPNRPDDPIRLDRSSPVLQLMQRMRDEVHRFAITTHRRARNARMKRSSLEDIPGIGRARASQLLVRFGSTERIAALSTDELAGAPGVGPVLARKILEHLNGSDAQRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4M703</accession>
    <name>D4M703_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">SY1_00690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00690"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.103"/>
    <dbReference type="HOGENOM" id="CLU_008831_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="291" mass="31959" checksum="FA13955451C21453" modified="2010-05-18" version="1">MNDLGMIVNLHKPEAVEMARRLLRWGQANGCSFLLPHLEASALTAAGLSDEEWLNTVKLAVVIGGDGTFLRAARYVLDSDIVLHGINLGHLGFLASSKPEEAECDLKSILEDRFDVLNRRVLRCVLYRDGVPRYTIYALNDVVLSKNAIARLLHIEVQFNGRFFGILPADGVIISSPTGSTAYALSAGGPIIPPHLDSMLLAPLCAHTLYSRPLIAAATDRISLIPRSSSRDITLTQDGQLAYEVFTDDRIDVDLPPDKLIRTVVLPGRNFLDLLQEKLGWGQSRPGVNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M723</accession>
    <name>D4M723_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01000"/>
    <dbReference type="HOGENOM" id="CLU_040933_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-50-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="329" mass="38115" checksum="8D67DFC39B9648D6" modified="2010-05-18" version="1">MLTHKQRIENALALKENDRTPYSMWMHYPNRDRHPRRLAELALKAQREYDLDFIKYMPFGLYTTIDMGVDLDVYEGFEKAPTQHEPVIRDVRDWDRIRPIDGTRGEYAVVLESQRILMEMMEEHVPFLQTLFSPATTLAKMCSPAVLVRHMREDPARVHRVLEMVTDTTIRFARASADLGADGFFYASQLSGRQTMEKAEHEAFVEKYDLAILNAVKDRTWFNVLHLHGAQVRIDEVQHYPVQGLSWHDRDEGPSMEEVRKYSTKAFVGGLSWGENWLTKTEEQVVGEVREMCGRPGLILGPGCVIEPHTPKKFLELVHKTVVERSCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M750</accession>
    <name>D4M750_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase class A</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.659"/>
    <dbReference type="HOGENOM" id="CLU_031960_9_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-77-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="280" mass="30683" checksum="BCFE0126013B2E18" modified="2010-05-18" version="1">MADNTVRKIPCREIYERIAKLDAFTGLYVEAIESGEVVEINPNRALCSASIIKLPILALALKDVGEGRLDWKKTYQIASANRVGGTGVLRELDEIREASLEKLAFLMIALSDNIAANQVIDLISMDRITPFCRSLGYTNTRCERKQLDMQAIREGRNNYTSAGDAGRMLSAVARGELVNPVASRLIHSIMSRQMCRNKLPAKIPAIAYWAVQDGMTLPAGSVLAANKTGELLDVQHDAGIFTLPDGRRYVIAMLTGEVKDANDAVNAIADVSRIVYDAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M758</accession>
    <name>D4M758_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombination protein MgsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_01510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.721"/>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-85-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="48"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="446" mass="49427" checksum="D6662530D0688EF4" modified="2010-05-18" version="1">MEERSLFEDEASQPLAARMRPRTLDEFVGQTHLLGPGCVLRRLIEEDHVSSMIFWGPPGVGKTTLAGVIAQRTRAAFINFSAVTSGIKEIRAVMQRAEEGRRLGGRTIVFVDEIHRFNKAQQDAFLPFVERGSIVLIGATTENPSFEVNGALLSRCRVFVLKALTAEELAGLLSRALSDPRGLGRYRAEVAPDMLNAIATFANGDARAALSTLEMAVLNGEPCGNGIRVTEEMLAQCTSRRSLLYDKGGEEHYNLISALHKSMRNSDPDAAVYWLARMLEAGEDPLYVARRVLRFAGEDVGLADPKALEIAVAAYQACHFIGMPECSVHLTEAVVYLSLAPRSNAMYTAYAAARSDAMEQLAEPVPLVIRNAPTRLMKELDYGRGYQYAHDAPDRLTDMQCLPDSLRGREYYRPTEQGYEARCKARLEQIRAWRRAHGDGAERYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M767</accession>
    <name>D4M767_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptide epimerase</fullName>
            <ecNumber evidence="6">5.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_01630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.735"/>
    <dbReference type="HOGENOM" id="CLU_030273_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-93-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00010">
        <property type="entry name" value="dipeptide_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="7">
        <location>
            <begin position="141"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (R)-substrate epimerization" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (S)-substrate epimerization" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="365" mass="39535" checksum="7D3ED4B394164F12" modified="2010-05-18" version="1">MRITRIRLGRISVPLRVPFKTALRSVDSVEDVVVEVHTDAGTIGYGEAPPTGVITGDTTGAIVGAVQDHIGRAILDRDVDDLEDLLQRVQRSIVHNTSAKAAVDMALWDLYGQLHHIPVYKLLGGARKCIVTDITISVNPPEEMARDARDAIGRGYDCLKVKVGANPALDVERLSAVRRAVGDDVCIRIDANQAWRPREAVRILNAMQEKGLAIEFVEQPVKAQDIDGLRYVTEHSDVPVLADESVFSPEDAMRIMQTRAADLINIKLMKCGGLTNALKIASAAEVYGVECMIGCMLEAKISVNAAVELACAKRIITKVDLDGPVLCSEDPILGGAVFREKEITVSDEPGLGIRGVEPGRIAYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B0</accession>
    <name>D4M7B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02290"/>
    <dbReference type="HOGENOM" id="CLU_3200164_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-138-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="45" mass="5030" checksum="BDB1FA64DFD5AA4F" modified="2010-05-18" version="1">MPREKILILVKACPEPSKGYIETTCVAGITEVGEMRRLLPVPFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C6</accession>
    <name>D4M7C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SY1_02500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02500"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1707"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-156-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="311"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="10">
        <location>
            <begin position="382"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="530"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL27771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="680" mass="71783" checksum="BD7D9D564EED41C4" modified="2010-05-18" version="1">MSIRGKLKLMVTVVFLIIVTMTLVTHFRSTSIVSDLQERTGNEIVTGSAGVIREYLDKYASVTRMAAAEVRHAILENPDVQRKDLEALMASLAGSVESLGLVGLYLGTSSDGQLYSSDGWNPEGYDSRTRPWYQAALKAQGGEPIFTTPYVDATTGTSILSVVQPISDRSGGLIGVVGVDIKMEALEQFVVSQKMFGHGSGAMILEDGLLVAHTNQSFVLKANLLNPADFSDSVSAFARRMVAGETGFARYEFQGEPHHAFFTPVGNGFFFYIFLPTKVMEARTHALTVLNVTMALIAIAFSTIFILFIIRGLSRAIRGMTSVTDVLSGGDLTARFEASGRDELARIAGLLNSMLDSISGALSRVRGEAEESSRQASTLAALSQETLASMEEVSASVAQVNGLMEAASASTEATGVSVSEIAASAQSSAQASTDGAQQAAQVAEAARNAAEEVTKVLKSMSSVGDAARQSLQGIRELGQSVDSISGFVATITSIADQTNLLALNAAIEAARAGEAGRGFAVVAEEVRKLAEESGRAAQEVSKLIANLQKESESSTVMTESAGPLLQRAMEDAESAQRRLDAAQEAIESLNQGIQSIAAAAEKQAASSEEIAEAMKNLSDSNAKIMDSTAAIRDSSHETTTAAESIATAAQSMAETSERLNGLVDAFVLDEKRDHPAFLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E2</accession>
    <name>D4M7E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_02740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02740"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-172-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061733" evidence="3">
        <location>
            <begin position="23"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="69"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="536" mass="59903" checksum="22D9DAF4A0A9D151" modified="2010-05-18" version="1">MKRSILCLLLAGLVFSASGAWAAGPRDVTIGLTADAHSFYPFTLNETINNAIMQHVFEPLVDLDRDLKFMPLLAESWDVNEDASVWTFHIRKGVKFTNGNDFNADDVVYSFGMAQLAGKSAFVYALATVEKYEKVDDHTVRVTCKAPNALLLCHLKDVYMLDKETCEAHDEDYNANNPMGTGKYELAEYVRGDRIVFKRNEGYWGEKPQAENVTYKPITNAGTRTANMMTNAVDMIVDVPVRDVSMLEKQKDITILKAPSLRIIYLNPSCVESPSKDSKFPLVSPTGKNPMVDKRVREAMYRAINEDEIISKVMNGYAVPAATYCPEGYNGYNPDVKRLAYDPALAEKLLDEAGYPRQADGMRFTVTLDASNDRYINDAAIAGAIAGYLEKVGIKVNLNLMSRNVFFSYIGATNKSGDNTHLCQTGWADSGGEGALIAMDCIYSMKPGEYVKQGWGGVNRGYYQNPEVDKLIEEAMQTVDAEKRSDLVKRAWKLAADDTAYIPLHFQMDLYAVGSRIDYAPRYNKFVYAWDISFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F1</accession>
    <name>D4M7F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin-dependent carboxylase uncharacterized domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_02850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1764"/>
    <dbReference type="HOGENOM" id="CLU_028967_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-181-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="356" mass="37330" checksum="AFBAD1FCDBD01D06" modified="2010-05-18" version="1">MRLVIQKPGTLTTVQDLGRWGHQALGMPVSGAMDAPALARGNLLLGNPAGAAALEVTLMGPTVLFEEGEGAVAITGGDLSPRLNGVPVPNWTIVAVREGDVLSFGGMTGKGCRAYLCVAGGIDVPLVMGSRSTYMKAGTGGFEGRKLAAGDALPVGEPWVLWRYTAGVGCPEDLRPDYAPKAPLRTVLGPQDSYVKPDGVKTFFEAEYKVAASADRMGYRMEGDAVIEHVKGPDIVSDGIPMGAVQIPGQGLPIVMMADRQTTGGYVKIGVVHAFDVARLSQRVPGAAVRFTQISQEEGIEISRREAAALKALQEHVTAAAGASAKAFRGLGRRASGAMKVRVDGVEHTVTWERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G2</accession>
    <name>D4M7G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine-cytosine permease and related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_02990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1778"/>
    <dbReference type="HOGENOM" id="CLU_035711_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-192-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="454" mass="49525" checksum="9DBF30D8B34B24DC" modified="2010-05-18" version="1">MVEDRTQITETMAETAEERRGQDYPLTEVPASARAGLFSLSMVLAGFTFFTSVMWAGGELGVHYKFWPDLMYVVIVGDFLLGTYAAVLGYIAFSTGLHAGLLSRFCFGNKGSRWSDFLYGFTQIGWYAWGTALITDLVLQLAGITKENTASYPYIYVILIIFFGFFFVMTAYGGYKAMELLSIVAVPLVTCLILYSIYVSTVKVGGLEGLQKILPKEPMTTAAAMTLVFGTFVSGATQSTNWSRFASKGWHAVIASFVGFFIGNGLMIFAGAYGGYVYQDPDVARVMAMQGMAIPAYVLLILNVWTTQDNEIYCFSVACCNAFRIKARKGITLTGAVIAIIMALGGIYNYLIDFIIISGTVIPPIGGTMLADWLIKHKRRYSKIAETEFKDYNLTGIGAYIIGAAAALFSPGIPPINGIIAAFIAYPILDKILQAMGMSQDHRVLAPGEGKQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G5</accession>
    <name>D4M7G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity Fe2+/Pb2+ permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_03050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03050"/>
    <dbReference type="HOGENOM" id="CLU_023979_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-195-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061734" evidence="7">
        <location>
            <begin position="34"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="473" mass="51903" checksum="7E9B31B5B48FCF32" modified="2010-05-18" version="1">MKFGFCKAWVRPLAGALLLVALLLSLGTRDAAAAAKKRYENWKAVAADMAVEFEEAQKDILADQWKDAHKHVNNAYFGYYEVQGFEKNVMVAISAARVSHIEGQFAAIKHALLGNTQGEKNALLSQVEDLKLKVYRDAMVLDGDLDESEPDSAGAAIYANTSLKRPDFLGAPAAIEAVASASSGEAGSEAAAMPAPQKRQRTDPNWITFVTAFGLLVREGLEAILVIVAIVAYLIKTDNKNLLKGVYVGSFAAILASIALAWVLQEWMGEQSGVARELLEGWTMFLAVAVLFYVSNWMLSKADTIAWERYISGKVQQSIDRRSHWTLIFAAFIAVMREGAELILFYQASFTGGMSDPVYIVYGIAAGVAVLVAVWIAFRYFSVRLPLKAFFLFTSILLFVMCVSFMGKGVQELTEADVITGRTVIPAMNGFTIEVLSIYDRAETLIPQIMLVIAALWITIPHLFSRKKPAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7I0</accession>
    <name>D4M7I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03300"/>
    <dbReference type="HOGENOM" id="CLU_914508_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-210-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="304" mass="33818" checksum="7FFF7EF3EEBBB4D4" modified="2010-05-18" version="1">MLTKAKCPACGGALELNPGLERGICVYCGSEFLVQEAIQKFKAEIDGLPTLKNMLIRAEQKLSDGDLKGAEALYEEILKGAPTCHEAWWGKFRSLLEGGYLPIRLVDCQHRVISLIKQGFIENAKKELKDIVAALDRADLQYLFGNNTTNALRAIEYAPEELKGVYQQKLDQILKDCKKISEDMKKLLTAREEELRKASIQEKKAVFLLVLGAILGGIMGYFWRGVIFGFILGMLWASETMKVKMIFLIILGTILVGGIMGYFWTGVIFGFIFGFILEVIREGRNEKGSADATTTDASLSSQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M5</accession>
    <name>D4M7M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_04120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04120"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1897"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-256-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="336" mass="37708" checksum="340D9FEF44D6052C" modified="2010-05-18" version="1">MDTLDKDTALIRVRGLKKYFPLKRQLTDFISGNPQEVLKAVDDIDLDIQTGENLGLVGESGCGKSTLARTIIRLYTPDEGSVLFDGKDITRMEKQELRKVRRDLQMIFQDPYSSLNPRMSVREMLMEALTFHKVCHKTEMEKRFYDLLSMVGIGAEAADRLPGEFSGGQRQRIGIARALAPAPRFIIADEPVSALDVSIQAQIINLLEELQERLHLTTLFISHDLRVVRHISHRVAVMYLGRIVELADTEALFEHPAHPYTDILLRAEPPLDPRLRSTETAISGELPSPIHLPSGCRFHPRCPNARKECSEREPLLSGVGSGHFAACHYPLLSRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M7</accession>
    <name>D4M7M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase, putative, group 3</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_04150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1901"/>
    <dbReference type="HOGENOM" id="CLU_021322_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-258-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="305" mass="32163" checksum="B50D4D5BE0F6C168" modified="2010-05-18" version="1">MAERFSGGKGGPRRSGGEGRRRPDLRGPGRPTEARRGGAPRGEPPRRSAERPLPPDDVCWGRQPVLDLVRNTPSRCTRLLIANNVRPPYLDELVDLARAGRVVYQLVAPEALDKLCPGERHQGVACRLTETVPVDLEPFLKALPAEAPALIVVLDHVEDPHNLGAIVRSAEAAGAAAAVYSRRRSALPGGTVVKTSAGASLRLPMIPVVNVVRTLAQLQAAGFWTVGLEGRAGASLWEDGLPARLALVVGAEGEGLSRLVGESCDQLLRIPIQGGVGSLNASVAAAFGMFEWSRTRASASAQGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P2</accession>
    <name>D4M7P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_04420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1927"/>
    <dbReference type="HOGENOM" id="CLU_056776_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-273-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="119"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="165" mass="19142" checksum="B0C506CCC839F7E8" modified="2010-05-18" version="1">MQQLYATWRMDYISAPKPEGEGCIFCAFPAERRDEERFILHRGEACYVIMNLYPYNPGHMMVLPFRHTSDYQSLTEQEVREMHRFTAHAVKVLGKLMHPDGFNLGMNLGKPAGAGVAGHLHRHIVPRWTGDCNFMPVLSETRVVSEAIEDTYRRLRTVWNEEMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T4</accession>
    <name>D4M7T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Parvulin-like peptidyl-prolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_05160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05160"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2011"/>
    <dbReference type="HOGENOM" id="CLU_034646_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-316-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007913171" evidence="2">
        <location>
            <begin position="27"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="147"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="303" mass="33465" checksum="2D5D21BEB28917F2" modified="2010-05-18" version="1">MSKQFKLKFAAVFGVAVLAAACAAWAATEAPKPTEENQVLARVEGREITEADVNAVLQSMGPQGMMMYGNPQGRQLILDEIVSMYLFSLEAEKEKLDGEQDFIDFMARVRTQSLAQRAMRNAVKDVKATEEEAQKFYDEHKDQFTQPERIHARHILISDDATSADTIARVQADLKAGASFDEEAKKLSLCPSAPQGGDLGEFTKEQMVPEFSDAAFALKEPGDVSEPVKSPFGWHIIRLEGRTPAQLIPFDDVKDQILQDLTGQQQQERIKAKVEELKKAYKVEMLAPVSDDAAAEAASDDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T6</accession>
    <name>D4M7T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05180"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2013"/>
    <dbReference type="HOGENOM" id="CLU_1529463_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-318-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="181" mass="20268" checksum="98A8D60262FCE2BB" modified="2010-05-18" version="1">MHGILTAAAGLAAAAFMLYFPYTWCRLRGEDERDFGLKWFMGRGAWRDVALALVLTLVPLTVVSMHWPVEWGGPGPRSLTPWQALDSLGGGVAAAFIEETFFRGWLQTLTVRRWGPWAGIPLATLAFALIHLVTLVGWLRVATFFPGLVMGWLRWRHGSVLPSILYHALCNVWAVWWAPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U3</accession>
    <name>D4M7U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05290"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2022"/>
    <dbReference type="HOGENOM" id="CLU_071039_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-325-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="338" mass="39052" checksum="192E1AE316038953" modified="2010-05-18" version="1">MDERTMQEKPERFDYDGFWKALIRRFWRELLRSAIPDLYRDADLEQEATPLDKELQDTLPKPGDEEQVSAKFVDTLLKIPLKDGGEQWVLLHIEVQGRGGEDLSRRMMRYYCLLFAHYDKNPIALAILTASRPKSETPGVYDFLQYGTRLHYSYNCVKLWNLDDEGLLASDNPFDLALYAAKKALAYDNEEQQKLIYLLKLTRILVSKGWSREDRSDLLAFIARVINLKDRALWEQYRKGAREIKGESEMMSFWDEELEQTRAQGRAQGRAEGRVMGHEEGREEGRQEGRQEGRLKGLMEVARRMLAVPLPVAQISELTGLTSHEIDALKKDAHAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W6</accession>
    <name>D4M7W6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">SY1_05590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05590"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2052"/>
    <dbReference type="HOGENOM" id="CLU_069535_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-348-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="253" mass="27510" checksum="482DCEC779957897" modified="2010-05-18" version="1">MFRIDLNSDMGESFGAYTIGGDEEVIKFVTSANVACGFHAGDPMVMDRTVKMARERGVAVGAHPGYPDLQGFGRRKMALTPLEIKNDVKYQIGALKAFVEAEGMRLQHVAPHGALGNLCQYDRDASRAICEAVREVDDSLIVYYCAGAVLGEEAASAGLDAKAEIFVDRAYQDDLSLVPRKTPGAMITDEDVAIARCVRMVKEGRVTALSGRELEIKGDTLCVHGDGPKALDFVRKIRKAFEREGIAVCNFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z3</accession>
    <name>D4M7Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06070"/>
    <dbReference type="HOGENOM" id="CLU_2953811_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-375-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="59" mass="6728" checksum="E40A205AE403955D" modified="2010-05-18" version="1">MSRLDELIQEYCPEGVEFKPIQEVYQRLRGTPITAAKMEEIEKADGDVRIFADGKTVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z8</accession>
    <name>D4M7Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06130"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2100"/>
    <dbReference type="HOGENOM" id="CLU_022936_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-380-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="499" mass="52453" checksum="64DA9DEE7EA472E1" modified="2010-05-18" version="1">MIMEGLLAVCQPLTLLFIAIGVAVGIVFGAIPGLTATMAVVMFLPLTYSMAASEGIAMLMALYIGGISGGLISAILLNIPGTPSSVATCLDGKPMANRGEAGKALGVGVVFSFIGTLIGIAILVVLAPVLCAFALKFQSYEYCALALFSLSMVVALTGTDMTKGLISAILGALLATVGLAPIDSRPRFTFGLFQLNNGFALVVLLIGLFAISEVMAFAETVRRRQDYTVEASVRIRGAGFSLAEFFGQIRNAIVSALIGVGIGILPGIGGGVSCMISYTVSKNTSKHRELYGTGIIDGVVASETANNATIGGAMIPLLSLGIPGDAVTAMLLGGLQIHNVAPGPLIYEKNGVVVHAIFFAMLIAAVMMLFFMLWGMRFFISVLKVPKNYLLPLVLVLCGIGAIGNANQIFDTYTMVAFGLMAYLMIKARIPTVPMILGFILGPTFEQNLRRASQLTSSDPFWNHPIFCVLIVATLLVVVFSARANMRDAAREEAAQGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M811</accession>
    <name>D4M811_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
            <ecNumber evidence="2">2.1.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EC" id="2.1.1.103" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06330"/>
    <dbReference type="HOGENOM" id="CLU_037990_11_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-393-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052667">
        <property type="term" value="F:phosphomethylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="217" mass="24285" checksum="DE16F751AADC0811" modified="2010-05-18" version="1">MTEEARDFRGKGRAFKGAFGGENYRRFAALFGFQERFYRQAVGDLRLGEGGRALDLGCGPGGLSYALAETSPASASIVGADISDDQLECARRGAGAFACKVEFLKASMDELPFPDGHFDLVMTSMALHETPPAVRRAAIAETARLLRPGGTFLLVDWSRPRFGLWGIVWYPFCRWGERNRDNWNNAYPAICRERGLSLTEDRYINSISRRQVFVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M817</accession>
    <name>D4M817_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_06400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06400"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2126"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-399-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="261" mass="28288" checksum="5FAE37F7B89574D1" modified="2010-05-18" version="1">MSALLSLEGVCRTYRRGGLFTRAEALHVLRGVDLDLSEGASLGLVGRSGCGKSTLGRVILGLERPNAGTVRFLGEDVASPARRAEFRRSVQAVFQNVRDSVNPRMTAGEIVAEPLRNFFSLTKGEAVERSCPLLEQVGLKAVDADKYPSQFSGGELQRVCIARALAPNPRVVVFDEAVSSLDMLVQARVLKLIERIRDEQGLAFLFISHDLRVVAGLCREVALMADGVIAARGRSVEELAAMGHPIIEELLASLPPAFPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M832</accession>
    <name>D4M832_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized NAD(FAD)-dependent dehydrogenases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_06610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2152"/>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-414-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="330"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="446" mass="49482" checksum="DC8B2AFED46DB213" modified="2010-05-18" version="1">MKVVVLGCTHAGTAAVLNTVALHKDAQVTVYERNDNISFLSCGIALHVQGLVKDPAGLFYCSPEKLAELGVTTRMEHEVTEVDLAGKKLKVRDLRSGREFEDTYDKLIVTAGSWPVEPPIENAKLENVMLCKNYTHAMEIVKRCASARKVAIIGAGYIGTELVEAFETQGKSVTFIDQMSQVLPRYLDPDVIDVIEKLYVEKGVTLAFGRTVKKFVDDGHGKVAKVVTTDGEFDADLAILCVGFRPLTALFKGKLEMLPNGAIRVDEYMRTSHPDIFAAGDCCAVYNNASRQYGYIPLATNAVRMGTLAARNLKAPTTRHRGTQGTSGIKIYEWNIASTGLTELVARELGIDYAVSVLKDNYRPEFMPTTEPFYLKLVYDRKTMRILGAQVRSKEDLTQSINTLSVCIQNEMTVEDLAFTDFFFQPHYNKPWNYLNSVALQALPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M836</accession>
    <name>D4M836_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_06700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06700"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2163"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-419-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="75"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="174" mass="18711" checksum="116015ABB7A859BA" modified="2010-05-18" version="1">MLYRMEYESPLGTLTAMSDGESLVGLFMDPVEARPGDAADEGLPVLAALRGWLDAYFDGRRPTPADLPLAPAGTEFQRAVWRILLDVPYGRTTTYGAIAAILAERNERGRMAPRAVGGAVGHNPISIVIPCHRVVGVGGNLVGYGGGMDRKVRLLTLEGVDMSRFFVPGEGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4M844</accession>
    <name>D4M844_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="6" type="ORF">SY1_06780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2171"/>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_0"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="350" mass="37470" checksum="13FFE38C060B67A1" modified="2010-05-18" version="1">MKKMTIAVDAMGGDNAPQAICEGAAQACAAFEDLEVVLTGDRERLLPLVEASPAAVRSRISIRHADEVIGMDEHPSAAIRRKRNSSLRVAMEMVRSGEAQSCVSAGNTGAIVAGGVLVVGRLPGIDRPALGAPLPTIERWTFLLDVGATVRCKPVNLYQFALMGSVYAERIMKVEAPEVRLLSNGTEEIKGDESVSGARELLSKSRLNFMGYTEGDDIAWGRSDVVVCDGFMGNVVLKFGEGLMYGAKSIISQEMGRRILPKVGMLFMIPMVKSLWSRFNYEKYGGTPLLGVKGVVIKAHGRSRAPAIKGAISAARRFIEEDGVGQIRAELDTGAGPQGESRGAQGQAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4M893</accession>
    <name>D4M893_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_07600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07600"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2248"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03256">
        <property type="entry name" value="ABC_PhnC_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="246" mass="27547" checksum="FF1318204CEAEA08" modified="2010-05-18" version="1">MLEIRNLSKSFKNAPWALNNVSLSVQEGDFIMLLGLSGSGKTTLLRCINFLQRPTSGYVSFNGREIRDKKSIISARKKMGMVFQNFNLIEQLTVLQNVLCGRLSYANKLLSCLKMFSEEDIDIALDCIKQVGLEDKAYTKTMHLSGGQRQRVGIARALAQRPVLLLADEPVASLDPRTSRQVLEILKEINKSYRITTVVSNHNLSLALEYGTRIVGLKNGELVLDKKRDQITNSEISALYGSNHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A1</accession>
    <name>D4M8A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_07770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07770"/>
    <dbReference type="HOGENOM" id="CLU_063199_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-486-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="234"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="297" mass="32812" checksum="6516B55AF510AE41" modified="2010-05-18" version="1">MGERTQRSRAADFLHRLMTEELDTLISTTIGTVLTCFAIIALMMPYKFASGGVTGVALITNYLWGLSPVWVITVGNALLLLWGWHYLSMRFALWTLYVTILTSLVLPVVEMFQYPVIQEPLLAAILGGIIGGIGYGMLFRVDASSGGMDVVSAAARKRWGADIGTMSLYINLVILLASFVAVSLEEVLFGALMLYVETLTIDNVVHSFHRRTQALIISGRVLEIKNYIMTDLERTATLIPAKGAYRDTPLELLLVILPRRQAASLKRYIASLDPTAFVIFSEVSEVVGEGFKSWLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B5</accession>
    <name>D4M8B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_07920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07920"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2284"/>
    <dbReference type="HOGENOM" id="CLU_003827_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-503-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="254" mass="27635" checksum="A184E284B6472E1B" modified="2010-05-18" version="1">MYLKCRVLQQAKVGAEAFALDLDVQDMAGLSRPGQFVMVRCWEGDDPFLMRPFSINSVDRKNGVMTLLYQVRGRGTALMAALRPADSVAVLGPLGRGFPVREGASRVALIGRGMGIAPLLLLAQDYAAHGTELHVYLSARSEEGLFNRSQFERLGARVTTTTAPSLNVTDRMAEDCRSLNFDAAYSCGSRRLGLGMKELHLKYGFPAYVSLEEHMACGLGACKGCACRTRRSEAGGEYALVCRDGPVFDVDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D3</accession>
    <name>D4M8D3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pfkA</name>
        <name evidence="16" type="ORF">SY1_08210</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 14">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08210"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.20"/>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 14 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="15">
        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="14">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="14">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="14">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="249"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBL28128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="318" mass="34072" checksum="7B81DC356E49611A" modified="2010-05-18" version="1">MDRIAVLTSGGDSPGMNAAIRAVARTCHYNDKECIGVMRGYEGLIEGDFKVLDRASVGGIIHRGGTILKTARSDRFKTQEGREAALLKMKEAGIEGLVVIGGDGSFHGAKALHEMGMPVIGIPGTIDNDVAGTDETIGFDTAVNTALEAIMRLRDTASSHDRLFIVEVMGRNAGFLALETAVASGAEYAVVPEIPLSIGNLCKLLRESHAEHKSHTLIILAEGVMSATEMRDKLQDTGGYDARVTVLGYIQRGGSPTSFDVVLATRMGAFATDNLLIGKSGFMVGNVNHKLVLSDLERSWTEHKNLSPELLNLIHKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D4</accession>
    <name>D4M8D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_08220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08220"/>
    <dbReference type="HOGENOM" id="CLU_1123368_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-523-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061839" evidence="2">
        <location>
            <begin position="23"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="249" mass="28735" checksum="E568DFB3A8BB1338" modified="2010-05-18" version="1">MKKTVWLVLALAICLVPHAAFAADLPELARWTRTSDFADRDEAQRVKVSVVYYSNEYVEALVKAEAEKNLWTRDETENYKYTLLKTLNFHDAIAFQLTLYVEGLPMYAQPFDRHISLWIGNKRYNPTDYDKRFNVKILGERDGMIWFPRYDPKTGAELLKGAKDIRLVLDGAISQAISPRGDAMWVWDITKDVEGALGNGRAMDRLELDRLIKRLEKLNQERGALQLQVDSIDQELNKVNSRIDELQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8F2</accession>
    <name>D4M8F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal-body rod protein FlgG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Distal rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_08510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.48"/>
    <dbReference type="HOGENOM" id="CLU_013687_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-545-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009426">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012834">
        <property type="entry name" value="FlgG_G_neg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02488">
        <property type="entry name" value="flgG_G_neg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="5">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="6">
        <location>
            <begin position="188"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="268" mass="29000" checksum="75350ECD732BD475" modified="2010-05-18" version="1">MLRALWSSASGMIAQQTNLDVVSHNLANVNTQGYKKRRADFEDLLYQVWREPGTPVEPNSTVPTGVQVGLGTRVTATPSFMTQGHFQITDNKMDWAIAGQTMAGENAFFQVTQQDGTIAYTRAGAWEIDGDGQIVSEDGLLLEPAMVVPENATSVQLTRTGRVMVTIPGQTEPQEIGQLELARFINPAGLRALGDRLFLETSASGAPIVGQPGQNGMPTVRQGVLEMSNVQVVEEMVGMIIAQRAYEANSKGIQTADELLRIANGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H0</accession>
    <name>D4M8H0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="7" type="ORF">SY1_08780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.75"/>
    <dbReference type="HOGENOM" id="CLU_158491_5_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="71" mass="8285" checksum="965983AFA68D77C2" modified="2010-05-18" version="1">MDATKLRELTLDELQEKYSQYKEELFNLRFQNAVGQLKNTSRIRDVRKTIARVLTIAGEKRQAMASDAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J1</accession>
    <name>D4M8J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_09120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09120"/>
    <dbReference type="HOGENOM" id="CLU_046737_12_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-584-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="153" mass="16881" checksum="D632CF1713594B96" modified="2010-05-18" version="1">MRNGYAPVVYGRFGGPAASIFDSMDRLAEQMGLFPFEGSGGLSAKTDLYRKDGKLCVEAELPGIKPEDVELHVYGDRLTLSAEKRSERTEGTEGKSYFRSERSWGKVERVISFPVEADPDSAKATFKDGVLTIEVDEKQEDRAHKKVAITSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J4</accession>
    <name>D4M8J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-only hydrogenase maturation protein HydG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_09180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09180"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.121"/>
    <dbReference type="HOGENOM" id="CLU_046249_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-587-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044271">
        <property type="term" value="P:cellular nitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018130">
        <property type="term" value="P:heterocycle biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042364">
        <property type="term" value="P:water-soluble vitamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024007">
        <property type="entry name" value="FeFe-hyd_mat_HydG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034428">
        <property type="entry name" value="ThiH/NoCL/HydG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583">
        <property type="entry name" value="PTHR43583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583:SF2">
        <property type="entry name" value="PTHR43583:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00319">
        <property type="entry name" value="Fe_hydrogenase_maturase_(HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03955">
        <property type="entry name" value="rSAM_HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="BATS" evidence="7">
        <location>
            <begin position="285"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="482" mass="54648" checksum="7BC1B4940CA842CF" modified="2010-05-18" version="1">MAVYDPKSLRATEFINDEEILETLDYADRNKENVRLIDELLEKARPRRTAGGCQCSGLTHREASVLLACEMPDKVARMYEVAEEIKLAFYGNRIVIFAPLYLSNYCVNGCLYCPYHTANKTIPRKKLTQEEVRREVVALQDMGHKRLAIESGEDPVNNPIEYILDCIRTIYGVHHKNGDIRRVNVNIAATTVENFSKLKDAGIGTYILFQETYHKKGYLELHPTGPKHDYDYHTEAMDRAMDGGIDDVGLGVLFGLDKYRYEFAGLLMHAEHLEAVHGVGPHTISVPRVKRADGIDPDVFDNSISDDTFTKIAACIRLAVPYTGMIVSTRESEAVRARLLQVGISQVSGASRTSVGGYTEEERPHDTEQFDVSDQRTLDEVVRWLMDSGHIPSFCTACYRAGRTGDRFMSLCKSGQILNCCHPNALMTLTEYLEDYASPETKRIGYEMVARELNRIPRERVRATARENIEAIRNSNRRDFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8L2</accession>
    <name>D4M8L2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbcD</name>
        <name evidence="10" type="ORF">SY1_09540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09540"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.156"/>
    <dbReference type="HOGENOM" id="CLU_038045_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="9">
        <location>
            <begin position="290"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="401" mass="44343" checksum="958E8CC6C579EDA6" modified="2010-05-18" version="1">MKFFHLSDLHIGLKLINRDLREDQEYVLDQIVRAAGEVSPDAVVVAGDIYDKAIPSVESVELFDRFVSKLAGAVPTAEIMMISGNHDSGPRVNLFRSVLQRRGIHMVGLPPRTPEDFIEKVVLWDEFGPVNFYLLPFVKPSMVRLVLDAGADASGGGDEAADATPRGLSYDEALHRLIDRETIDPEQRNVLVSHQFYLPSGAVPSGVERMDSEVRTVGDIDGVRSDVLERFDYAALGHMHKPMEVGNERCRYCGTPLACSVSEAGQQKGIIVVELGEKGSVKTSVLPLTPLREVRVITGAFSEVLGQGCEDYVTVVLTDKEDLDVLDMQDRLRACFPNLLEIRRELPQRAGDRAGRGAAEAEMSPFELCGSFLKEQWGGRELDEEERSLLQDVINSVQEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N6</accession>
    <name>D4M8N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted P-loop ATPase fused to an acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09910"/>
    <dbReference type="HOGENOM" id="CLU_108859_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-630-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="147" mass="17144" checksum="B3EC1EB65F0EAAC2" modified="2010-05-18" version="1">MVSVKIIDGDKTKYMDLLLIADESVSMIEKYLYRGDMFALYDDDIKAICIVTQEQLGVYEIKNLVTVPQYQRNGYGQKLISVVADYYRKLNGELYVGTGNCPTILRFYERCGFKKSHIVKNFFIDNYDHPIYEDGQPLIDMIYLKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P2</accession>
    <name>D4M8P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09990"/>
    <dbReference type="HOGENOM" id="CLU_2879341_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-636-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="63" mass="6989" checksum="90C97AAA30C27469" modified="2010-05-18" version="1">MAIFKCKDCGKEVSDKAVACPGCGRIFTHEEKKAGVKKQRMVLWLIAVLALISVLWGLLSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P3</accession>
    <name>D4M8P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10000"/>
    <dbReference type="HOGENOM" id="CLU_085959_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-637-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="243" mass="28689" checksum="96062A91D92D94F3" modified="2010-05-18" version="1">MRRIFPVPFRFLGEEKRFKKWQWIMIEAEAAVGDNRKESRRGNFDTIQLQELMKSGTGWRARMEWLKRVPRIRGFLPPDQGKRCTPAVPEEVSLALYVPDSPVSLEIKKGAEDWTPKEKEALLQSDNPLFSRKALDLPPALKKVPYNFYYFFEAPVAEGGVKEVRLKITDWEIGALYWRCVREHGDDWERFLRNKYEAEANKLGPMILMGNMHRHPDQWLAISVFLPPRQYRELFFQKGLFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q5</accession>
    <name>D4M8Q5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ORF">SY1_10180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10180"/>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="106"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="308" mass="33929" checksum="4BC5169B5F8381F5" modified="2010-05-18" version="1">MMDHLIDAFMASVQNRSQSEHTLVNYASDLRQFAEYLEGCGASEVRSVEAPILRAYLRALFGWGYAKATVARKLSSLRSFFAFLKERGVLERDPARNLRGPGAPRRIPRALSEEVVERLFAAAGESEEALRDTAILEVLYGCGLRVSELTGLRWEDVDLDERWLIILGKGSKERRVPFGRCAQRALTALRGEQALGPFVFVGHEGAGSPGREGRRGRTGQKPVTVRTVHRVVTALAARAGLEGVTPHVLRHSCATHLLEHGASLKFVQEFLGHESLATTQIYLTVSASWMKESYAAAHPRAHVGTDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R9</accession>
    <name>D4M8R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted endonuclease distantly related to archaeal Holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10530"/>
    <dbReference type="HOGENOM" id="CLU_115353_2_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-670-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="127" mass="14176" checksum="FAA9CF80C1930CDD" modified="2010-05-18" version="1">MSSAGDLGRLAEGWATDYVRSLGWRVLGRNVKNRCGELDVVALDEVERELVIVEVRCRTLGRVQAPLDSVGPHKLRALIRAGRTLADEMGWDGPWRIDLIGVTVGRGSEGWRLEHVRDVTRGMEFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T4</accession>
    <name>D4M8T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+ transport system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_10830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10830"/>
    <dbReference type="HOGENOM" id="CLU_150646_12_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-685-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="83" mass="8936" checksum="FE559062EC1C4C7F" modified="2010-05-18" version="1">MSEVTLAELAPGESGMVVGIKGRGMLAQRLVDMGLYPGVAARVVRRAPLGDPIEVDAEGALVNLRYEEAHFVKMKKLNNGQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U4</accession>
    <name>D4M8U4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnfA</name>
        <name evidence="9" type="ORF">SY1_10970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10970"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.307"/>
    <dbReference type="HOGENOM" id="CLU_095255_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-695-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01943">
        <property type="entry name" value="rnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="193" mass="20768" checksum="5E25AF42068CBA27" modified="2010-05-18" version="1">MTELFLLFVSSIFVNNILLTRFLGCCPFMGVSSRLKTAVGMGAAVVFVIVLASLMTWLTYNFLLAPLGLEYLYTLAFILVIAALVQFVELVLKKLNPTLYKALGIFLPLITTNCAVLGVAVLNMSERYTLTQSLVNALGSSLGFLLAIALMAGIRERVETNEGIPACLQGLPLTLITAGLMSIAFMGFTGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V2</accession>
    <name>D4M8V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_11090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.320"/>
    <dbReference type="HOGENOM" id="CLU_042763_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-703-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="368" mass="39674" checksum="5A90CDFFB98D63F9" modified="2010-05-18" version="1">MIRRFIENVGWPRFIIGLFLLSLFIAAPFVGVRVDTSLSDVLVRFGMNGVMVLAMIPMVQSGCGLNFGLPLGIIAGLLGATLSIEFNQGVLAFAADLAAGRPWLAFLASEAARAPLSFASAIVIAVPIAAVLGFFYGKLLNRVKGDEMMIATYVGFSSVAFMCIAWLLMPYRSPTMIWGYGGSGLRTTISVNGYWLHVLNDLLSFQQGHLFVPTGTFLFFAVLALLMWVFMRSKTGTAMTAVGSNPDFARASGVNVDRMRTISVVLSTILGAVGILVYEQSFGFIQLYMGPFYMALPAVASVLLGGASVNKAGIVNVIVGTFLFQGILTMTPSVINSVLQTDMSEVIRIIVSNGMILYALTRKVRVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V4</accession>
    <name>D4M8V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11110"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.322"/>
    <dbReference type="HOGENOM" id="CLU_137433_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-705-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="155" mass="16969" checksum="35926639A9D529EF" modified="2010-05-18" version="1">MMRFLQRALALILLVALGVWLFYVGREHQVLLDNKTIELEGRTFKALQEVRVSVNGAEPVELYPRDRDMVKVVGPAFSLRVEIEDPGSDVELVEREVRVGFGKDLMLSFPLMAASRDFVLPPPTSQQAPAPEAVASEDALASGVGEEVPAAPTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V5</accession>
    <name>D4M8V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Propionyl-CoA carboxylase carboxyltransferase subunit</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_11120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11120"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.323"/>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-706-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="266"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="519" mass="56049" checksum="C250B419F60AE1B4" modified="2010-05-18" version="1">MGFRSMEELCEELREKRAAAFNGGGEKAIAKQKEKGKGTARERIDQLLDPGSFVEIDEFVTHRCTNFGLEKTRPLGDGVVTGWGTIDGRKVVVFSQDFTVLGGSLGEMHADKICKVMDLAMEMGCPVIGLNDSGGARIQEAIDALNGYGKIFFRNTHASGVIPQFSVIMGPTAGGAVYSPALTDFIFMVNKTGVMHITGPAVIKAVTGEEVTSEALGGAATHNNISGNAHFMAADERECFAQIRKVLSYLPLNNLDDAPDKPTNDAVDRADPSLRETVPTNPNVGYDVHEVLRKVLDDGEFTEVQAGWAQNILTGYGHIGGRSVGIIANQARVMAGCLDINASDKASRFIRHCDAFNLPILTFVDVPGYLPGVTQEHNGIIRHGAKLLYAYSEATVPLITVILRKAYGGAYLAMASKSLGADVVLAWPQAEIAVMGAEGAANIVFRKEIAEAGNPEETRAEKIDEYRKAFANPYVAAERGLVDRVILPEETRLSIWQALNALESKRVSRPDKKHGVIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W7</accession>
    <name>D4M8W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripartite ATP-independent periplasmic transporter solute receptor, DctP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_11340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.342"/>
    <dbReference type="HOGENOM" id="CLU_036176_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-718-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061750" evidence="2">
        <location>
            <begin position="27"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="332" mass="37152" checksum="04E012C92F10498E" modified="2010-05-18" version="1">MKMKRRMLLSVVALLCVGFWTKAAFAAAVNIKLAHGGSLEHQYHIGAMEFKRLVEEASNKEIEVTIFPQGQLGGERELAESVRMGTVEIGELAASNMAGFVPELQVFGIPFLFTGKNAVYSVLDGEIGAELNGYMLNKGFVNLGYWEVGFRNMTNNVRPIKKPEDAKGLKIRVQESKIWIEFMKALGAVATPIPFGELYSALQQKVTDGEENPIATIYSMKYYEVQKYVSMTAHTYEPALVIVNQQWFEGLDPKYQAILKDAAIKTATLQRVKLAELEKERLEIIRKAGVEIEENPDHAAFAELTKDLYKVISDTVPEELVMRIRDAIAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X4</accession>
    <name>D4M8X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_11440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11440"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.350"/>
    <dbReference type="HOGENOM" id="CLU_599574_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-725-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="250"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="456" mass="49912" checksum="AE87E237A527AD93" modified="2010-05-18" version="1">MPTPFEENGLQAPPQRGATLQIISRLCSLAAVFLAAFLVVYYGNALLLRLHGHLLDRQGNVTTLSFALSRVLIHGLQNMLIVVAWQAVARRLSHRTAHFADAVNIVVPPVAFMATAWLLPHLSPNLTLSFSMSPVLAFLLLCLFHALTLRVENVLDRSLALILWLFASHSLEMITGVPFPQSALPEADAAFVSMTGFTLFFCFLAGAMSSSWLLVKYSIRLSVLKNSWIGAELKRGETSVSGINMLDVNNLVHDMKNVIAVIKGTARMMDKKEPSERTALLLKAADYMGTMTQELLSGDEKHDLALSELFRTIERHSSAFPWKDEVSMHAAPEVEGAHIMANKLRLIRAIFNILDNAWRGNALVGAHGILLQVRLDIHGRMAEFEIIDNGPGYSGTQAAGQSGWGSTGLGLAFTRRVISLHGGSLAITSRKDQKRGARVVIYLPILQGPRPSTPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M913</accession>
    <name>D4M913_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.435"/>
    <dbReference type="HOGENOM" id="CLU_053697_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-766-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="382" mass="43188" checksum="44C0057E5C0F0BF0" modified="2010-05-18" version="1">MLSLPKNFESYDEKRRNAFLALYDVKKKGKKVVGTFCSYTPTELIHAAGAIPVGLCGNSEQGILEAETRLPKTLCPLIKSSYGLAMTDQCPFFYFSDGVLAETTCDGKKKMYELLGEIKPVHVMKLPQGKDQALAVESWTEEVRLAAGFLEDLLNVEITEEKLHDAIVYRNRVRRALIELYEVAKAKPSPVSGYELTTVSESADFHFTDDSLIEKLAEKTREFRHRVRETTPDRPRVLLTGCPNTGLREKLIHRMEDMGADYVCSDHCAGPRTLRFVVDEDKDPYEALAERYLKINCSVMTPNGGRFDDLKHLVSEYKVDGVVEAVLQGCHTFAVEAWNTKKTVYEELGLPYLRIDTDFSQSDRGQIETRLGAFIEMMRMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M939</accession>
    <name>D4M939_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type I secretion system ABC transporter, HlyB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_12340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.474"/>
    <dbReference type="HOGENOM" id="CLU_000604_95_6_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-792-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030256">
        <property type="term" value="C:type I protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030253">
        <property type="term" value="P:protein secretion by the type I secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010132">
        <property type="entry name" value="ATPase_T1SS_HlyB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01846">
        <property type="entry name" value="type_I_sec_HlyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="10">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="178"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="491"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="525"/>
            <end position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="746" mass="83189" checksum="BB3219A4D8D18851" modified="2010-05-18" version="1">MFDEVHDPTHRAGDPEEIKRENLRLFDDALLALAVAAQIAGLPADPEGLRRAFPASDAGALPLTLLRAARSLGLKAKRIETSLEKLDRMPQPTLLLLPDGQVFVLLAADFKKDKKRVMLLRPGEKQPFVWDCARLEEVWHGDAIPLVRRFSFAELGRKFGIGWFLPVILRFKRHLVEVFVGSFFLQTFGLITPLFSQVIIDKVLVHKGLSTLDVLVIGLFLINVFEMVLNVTRTYVFSHTTNRVDVILGAKLFKHLLALPLPYFEARTVGSTIARIRELETIRSFITGTALTVVLDLIFTIVFIAVMFFYSPTLTLISLAALPFFIALSAMATPAIRERLNRKFERNAENQSYLVEMVTGIQTVKSLAIEPQLNGRWEGMLANYVRASFRAGFLSSLAGGVAQLIQKTSTLAILWFGARMVMKGDFTVGQLIAFQMLSGRVTEPILRLATLWQDFQQVRVSIERLGEVLNFPAEPESTPGRSSLGRVRGRIEFDHVQFRYKMDGPPILDDVNLVIEPGTTVGIVGRSGSGKSTLTKLVQRFYVPVNGRVLVDGVDLAQVNPPWLRRQIGVVLQESFLFNRSIRDNIAVVDTAAPLDRIIAAAKLAGAHDFIMELPDAYDTLVSERGASLSGGQRQRIAIARTLMTNPRILIFDEATSALDYESERIIQHNLQDICRGRTVFIIAHRLSTVRMADVIIAMDRGRIVERGTHDELLGNADGLYSFLYRQQALLGDEGSWEGGRKTCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M958</accession>
    <name>D4M958_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12770"/>
    <dbReference type="HOGENOM" id="CLU_2301742_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-811-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="100" mass="11036" checksum="8AF33B4D72A42D86" modified="2010-05-18" version="1">MVGGGRVSFCRFALIFFCRIARNGTLRPLSLLQTVGKMGKVEVMILVPVKTERVEAYLFTYPVLGTSVPVAVNEAHFAVSRVLFPETCLPRRGVTFSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M967</accession>
    <name>D4M967_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_12950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12950"/>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-820-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="60" mass="6318" checksum="BE900040575129A5" modified="2010-05-18" version="1">MKISLDQTACIGCGLCVQISPENFALDEGKGTAKVVKAETEDESAREAESSCPVGCIRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M975</accession>
    <name>D4M975_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Met) cytidine acetate ligase</fullName>
            <ecNumber evidence="1">6.3.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmcAL</name>
        <name evidence="2" type="ORF">SY1_13120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:58144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TmcAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13120"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.541"/>
    <dbReference type="HOGENOM" id="CLU_038915_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-830-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01539">
        <property type="entry name" value="TmcAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008513">
        <property type="entry name" value="tRNA(Met)_cyd_acetate_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37825">
        <property type="entry name" value="PTHR37825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05636">
        <property type="entry name" value="HIGH_NTase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="409" mass="43966" checksum="6F14EA6C970B9245" modified="2010-05-18" version="1">MKDITGPAVGIVAEYNPLHNGHRLHLAAALARCGDAPCVAVLSSNFTQRGEPAVVDKWTRTRMALACGADLVIELPFVFAVSAAPFFSAGAVDLLVRTRLATHIAFGMEDSTRDVSPILDILIHEPASFKQRLKDELFRGASYARAAAGALESLLPGSGVFLSSPNNLLAVSYLLRVQELGGSLTPLPIQRLGAGHGDAAPGPLTSSLAIRAALRRGKTSMEDGGPVASAVPRTSLSLLRQAKEEGRLCASGEGLWPMLQAILIRSGPEDLRGFDGMDEGMENLFLKRRADSAGMEDFMARCASGRYTRARIRRTALRLLAGVDRWSWQAAARVGVPYARVLGANETGRALLRLRAASSSLPLITRLAAARDPVGRFAARMEFRASSLYEALLPAPDPRHEERQRPIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M987</accession>
    <name>D4M987_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoglutarate ferredoxin oxidoreductase, alpha subunit</fullName>
            <ecNumber evidence="4">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_13290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13290"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.565"/>
    <dbReference type="HOGENOM" id="CLU_017038_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-843-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="3">
        <location>
            <begin position="275"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="377" mass="40512" checksum="F774F37AE30D6BBC" modified="2010-05-18" version="1">MADVAFWQGNTALAHGALAAGCNFFGGYPITPSTEIAEVMAEELPKLGGHFIQMEDELAGIAAAIGASIAGAKALTATSGPGFSLKQENLGLAYIAEIPLVAVDVMRGGPSTGTPTKVAQQDVMQARWGTHGDHATICYSPSSVQECYDLAIKAFNAAERFRQPVLILGDEVVGHMREKVVKKAPGEVKIVNRVRPTCDPAKFTPYLPDPVTGIPPMASFGDGYSWHVTGLTTNDWGFPTNDNAEIEKKILRMMSKVSRARSEIVEYEAEYMDGADVVVVAYGSVARSALRAVRDARKAGIAAGFFRPITLWPFPDEELLQASLGAKTVIVPELNCGQLVLEVDRVFHGRSDVQPLNLVNGELFKPSEIGRKIKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A9</accession>
    <name>D4M9A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13650"/>
    <dbReference type="HOGENOM" id="CLU_645132_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-865-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="420" mass="45274" checksum="2341A6EBF16C9A04" modified="2010-05-18" version="1">MVVTFALASWKLKSPELSMVVTAVVGALVGKLGFPVRLFVEGTFTYFDVAFTFLTASIFINFYSATGAMDALVRRMVGRFYEHKWVLFFLLAVIMLIPGALTGAGSVSMFVVGGMVATVLRFMGIRETRIVAFIYVTSMLAAVAPPINLWVMLMCAQANMPYVGFDVPLLAPIAVITVFTVFYLLRGGEPKPKDEVLASLPVPPDGMTAFRIATPLIVLILLLVLSKYAAFYIPILGIPLIFIISTAVAMLLSPRKLGLSGWCGVLSETSEQVFPLLATVISVGVLVNIMAATGVRGLIAITFVTLPVRLIYTFAPFVLPFAQGALSYSSGIILGTPLIFLFNSIGVNVTIVATALSLIFPLGDCLPPSRISGRVAIEVSGYKGSYLSFLRSILVPAIFMGLVAVGMLIYANDFKWLIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B7</accession>
    <name>D4M9B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13760"/>
    <dbReference type="HOGENOM" id="CLU_2342695_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-873-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="97" mass="9823" checksum="276013DC68EB2E9A" modified="2010-05-18" version="1">MLENGVNQANGAEKGQAVVASGQSNALGICSIVCSIVSIFLAALVFAPLGVLLGLIAAFKKQVALGVIGIVIGVISLLLSPSFQLLLVGMGLRMGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F5</accession>
    <name>D4M9F5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="13">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">secA</name>
        <name evidence="18" type="ORF">SY1_14650</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SGP1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="13">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="13"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14650"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.704"/>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="11 13 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="17">
        <location>
            <begin position="1"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="82"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="873"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBL28500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="939" mass="104993" checksum="D3C86F07EC9092D7" modified="2010-05-18" version="1">MLGLDPNDRALRKYGTQVEDVNALSDAMEARSVEELRTRGAELRGLAREGADLNELLPEVFALAREVSWRTIGLRHYDVQLIGGMALHDGHIAEMKTGEGKTLVATLAVVLNALKGEGVHLVTVNDYLARRDAAWMAPIYNFLGLSVGVIYPYMPAEERYEAYRADITYGTNSEFGFDYLRDNMVMRADQMVQRPHAYCIVDEVDSILIDEARTPLIISGPSDDNVDLYVKADGVARQLKEGADYEKDEKERSIAVTEAGIQRCEDALKLPGLFSDAAHSDLAHRIVQALKAHRLFTRDVDYVVKDGEIVIVDEFTGRLMVGRRYSDGLHQAIEAKERVKVGRESQTLATITLQNYFRMYRKLAGMTGTAATEAEEFKEIYGLQVVTIPTHRPMIRKDNPDVIYGTMVEKFNAVADDVEECHKRGQPVLVGTTSIENSERVSKLLKARHVPHQVLNAKHHEKEAHIVAQAGHEGAVTVATNMAGRGTDIMLGGNPEFLAREKLLATRPEVDWGGSGLDEESVYEYFVRYSNLDTENLAANYLKEQRVNAAEGAEIVGRLRGIFARIKEAYDAFLVDFSAACREEHEKVAALGGLAIVGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSLEDNLLRLFGSERIQGLMGKLGMTDGEAIESGMLSRIIESSQHKVEEMHFDIRKQLLAYDNVMNQQREAVYHERHMILTDEDVVAYGRDVVHGVASSILDRYFPEEGEADPARAEARFRALFGAGSGDEVARVDSRAGLELVREEVLKEVESRYDRKMATLPPEVAEGLVRYVLLNTLDNAWRDHLLAMDELRRGIGLRAIGQKDPLIEYQFESFNLFQEMMERVKEAIAEQIFRVQVVSAEGPSRERRVSESRDFQLPGFGPEGRGEDPLPQPGGGKRQPVRRGTKIGRNDPCPCGSGKKYKHCCGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M8</accession>
    <name>D4M9M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.856"/>
    <dbReference type="HOGENOM" id="CLU_395233_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-985-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="697" mass="73410" checksum="29B406428D8CD4E1" modified="2010-05-18" version="1">MSIRMRKFGGYGMGSRGTATLSSGQINSYAPISAMTDRTVTIGLKNVGTLDDFAPDVEVLLHVSATKGSETAKLGEYAFARIRSIEGSVLTLDRMPVWSVSDSDLPNYWIQAVTVPNFETLTLKGALQAATYSASTHCGGILALKCSKELVFNGGRMDVLNKGIPTGAAALRPAIPEEATEEGRLFIHSALPVMNRGNGVVMVCARRTTFDTVAVIGASEFGNPDKGAGEGGASILFVSDELVNFRAEAISTGGISGGVGRGRCRIATRSEPALQIPSRELLYGHDLIHDPDALRRLGFRSFGDGRHKSVTNPTEVLCGYAPISRIGADLKTAETQYLQNAFYAPLEEGALALFHVSATKSAHIQDYGRYAIRRIVHRTASGSNAVFLLDEPLPVPQNITDNYWCQLIGIPQFETLTLRDFTLNVPAWNDSVKCGAILPLACSNLLSLTNAKVLTEPGKFPVGRRWGDDDNKRFINQTNAVGATRMMLGEKNGAVLLLAKQIAADGASRVGGEQSPLLLGGKGGEPFLFSDCKYRDEDVWDAPSKARGKSGGSGFGGGQGAHSGQGASINVFGVAVVKGTTPCPAGNDAVDGWGAPKTSQYSGFRYSMPGYTGGGVTQGTWSGHAEGTTTYSGASGACILVVSETSPDELHAVMSSGGHGGRPDIGVGTKKDGIRFYPGFCGGGSGQLMYFHVGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N4</accession>
    <name>D4M9N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15930"/>
    <dbReference type="HOGENOM" id="CLU_1568470_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-991-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="170" mass="18957" checksum="1DFDAA1C1AC34A8B" modified="2010-05-18" version="1">MIPRVEEALIAELERRIVAAMPETAPGDGNMPETFITTIESRTVVPNVQEENDLTVFCMVTAEVSVIFYSQKTRCDYSPLLADFCRHPWIDLGGVYAKVRIEGSEAAEGPYLSNDAWLFRAEYPVFEVEPGHAWQTPAIGHVSVGVQDIYPRALPDTTNEPEGGGRFVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P1</accession>
    <name>D4M9P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriophage capsid portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16010"/>
    <dbReference type="HOGENOM" id="CLU_873620_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-998-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="318" mass="35591" checksum="E8DF17C55725B706" modified="2010-05-18" version="1">MAVGLEYEAPKPAEAFLESISGPEPFLELLHRVAFDWECTGNAYLEVARSRKGQIGELYHVHAQTVFSRVRENRLVGYVQETDGTVEFAAFGARDGRNELFAFRRYTPLSTWYGLPEWVAALEALRLDQEKKSFYAAFFRNYAVPSLAVVLTGAEFDEETEKTIREGFKQVKGVDNAHKTMLLSVPFENSKIEFQRLTAELKDMPFDKLSQATREEILAAHGVPPRLVGIVTAGQLGGGSEMEGQMLSFIEMKVRPRMKYLENRINLLLRDAGLPEEFRLKGITPSIPKEQADAKTGDTDKAVVEAEILKGLDLLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P2</accession>
    <name>D4M9P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16030"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.872"/>
    <dbReference type="HOGENOM" id="CLU_124897_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-999-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="129" mass="14318" checksum="8FA390A1BEFA0475" modified="2010-05-18" version="1">MGDLTEHFSRHELACRCGCGLFNARGRLLATLEAIRKAVGKSVHIESGCRCAEKNADIGGKPDSGHLTGEAADIWVEGLSNRDLGVVIKDLHRRKLLPYLRYCYLIRGRTTTRVHVGVDEKPRRGVFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P7</accession>
    <name>D4M9P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16110"/>
    <dbReference type="HOGENOM" id="CLU_2316195_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1004-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="99" mass="11454" checksum="436B4C4C179FBF90" modified="2010-05-18" version="1">MKKFRMKVACEATFTVLSPFAIEIEAEDEKTAEEQAKKLIRDFMETRDEDPLLDVARHEWEAQAILNGHIGQKASIEFDDYQDMYLTNIKEIEIMKGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R7</accession>
    <name>D4M9R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.910"/>
    <dbReference type="HOGENOM" id="CLU_195842_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1024-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050485">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010187">
        <property type="entry name" value="Various_sel_PB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01918">
        <property type="entry name" value="various_sel_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="76" mass="8554" checksum="C6AA505F7B1E2FEF" modified="2010-05-18" version="1">MVKEIERKLPVVHMCTIVPISLTVGANRIVPTIAIPHPLGDPTRTPEEEKALRRRLVERALKALQTDISEQTVFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S4</accession>
    <name>D4M9S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16490"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.919"/>
    <dbReference type="HOGENOM" id="CLU_148741_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1031-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045441">
        <property type="entry name" value="DUF6506"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20116">
        <property type="entry name" value="DUF6506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="95" mass="10590" checksum="30D1D67A24A3D238" modified="2010-05-18" version="1">MRFAFLIMGDDFNVEADRASIHDGDAQIVGVANLKEAKEEARRLQREGVDCIELCGAFKEDGAREVIEATGNELPVGYIVHFPEQDEVYRAAFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S7</accession>
    <name>D4M9S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted Fe-S oxidoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_16520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16520"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.922"/>
    <dbReference type="HOGENOM" id="CLU_009273_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1034-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027583">
        <property type="entry name" value="rSAM_ACGX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04340">
        <property type="entry name" value="rSAM_ACGX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="358" mass="41230" checksum="0369181E859A8F0B" modified="2010-05-18" version="1">MKEYFSFQWHITDECDQRCRHCYIFSGDPRRKLDSMTWKQLQETFYNCLDFCDVHDRLPYFYLTGGDPILHPDFWRLLKLFHKHAIPFTIMGNPFHLTDRVCRELKSLGCQKYQLSLDGLRETHDWFRKRGSFDCTLEKIGCINQAGIRSVVMTTVPKANHTEVPDIIDAVVKARASVFAFSRYVPSGGELDAGITAQEYRRLLAICDRKFTEHETEGCETYFNKKDHLWTLYEYETGKFKIPSYACDGMIYGGCNCGNCHLTILPTGEIYACRRVADSKVGSVFEDRLADVWVTGMEAFRNYDDFSKCSRCKLKQFCRGCPAVARGTNGDFYGDDPQCWASVENGLLTPEMSKGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T5</accession>
    <name>D4M9T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_16720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16720"/>
    <dbReference type="HOGENOM" id="CLU_1649654_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1042-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061857" evidence="2">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="160" mass="16757" checksum="05B6895E0E780F24" modified="2010-05-18" version="1">MAVMWKLFSLNGRPFRCAAGAALLLAGALCVAPAPVWANGNASADAPAPVAEPAPKGTEAPVRKSVRKAPLKKAKPAPRARKAVRKATALRPAVSALQQGIALMEQDRCSAALPWLRRALQEDRRSAAAWVLVRPVSRADGAVLRGAVLLHEGPGVRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T8</accession>
    <name>D4M9T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16840"/>
    <dbReference type="HOGENOM" id="CLU_2154689_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1045-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="111" mass="12178" checksum="5C238A008487523A" modified="2010-05-18" version="1">MVQPISLLMSQFNVENSAQLTRSALAAAQETGQGQEVVRDSLRRTQMVQANEAAAGVRKVRRRTDEEEREGRRRDARDSFGRSEPKGDAEAGAVHEAAAAKVQGKGFDFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U2</accession>
    <name>D4M9U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_17010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17010"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.966"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1048-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="308" mass="34214" checksum="707ECF93932DAB5F" modified="2010-05-18" version="1">MLRYIIRRVLFLIPVLLGVAFCVFTLLYLTPGDPARMVLGDMATDEAIKEFRDKEGLNDPYLVQFGNYVWKAINGDIGRSYSSRRPVMKELLTAFPYTLKLSAFAMIIAILIGIPCGIISAIKQYSWFDTITMIFAMVGLSMPVFWLGLLLILLFSVHLRWLPSSGFSTFKAMILPSVALAAQSISMVTRMTRSSMLEVVRADYIRTARAKGQKESIVIWVHALRNALIPVVTLCGLQFGSLLSGAILTETVFAVPGVGQLMIRAIMARDYPMVQGGVLFVAIAFSIVNLLVDLLYAYIDPRIKADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U5</accession>
    <name>D4M9U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_17050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17050"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.969"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1051-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="37301" checksum="94A7F7A0BA04D0DC" modified="2010-05-18" version="1">MTDNNKPYIKVEHLKKYFSTKRGMLHAVDDVSFEIQRGETLGLVGESGCGKSTLGRCLIRLLDSTSGSVMLQNPEDGSCIDVTKVDAATMKDLRKRVQIVFQDPYSCLNPRLSVWELIAEPLMVNRVYSDKAAMRKRIRELMSTVGLAERLENSYPHELDGGRRQRIGIARSLALNPEFIVLDEPVSALDVCIQAQVLNLLNELQKEFNYTYVFISHNLSVVKHVSDRIAVMYLGQIAELSEYRELFKNPMHPYTQALLSAIPLAKLDVNRERIILEGDVPSPIEPPDSCRFMGRCRYRQDVCAKGTPPLTEYAPGHFVACHFAGKLAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V7</accession>
    <name>D4M9V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17240"/>
    <dbReference type="HOGENOM" id="CLU_2568909_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1064-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="81" mass="9414" checksum="BAF44F2F48CDDA34" modified="2010-05-18" version="1">MAVLSVELEVAEDVLMEYLGILSREISEERRKSVVNERKISVLQEEHEKVKNMRHSLTLEDSALIDRVLYLYGLAVRRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W7</accession>
    <name>D4M9W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1003"/>
    <dbReference type="HOGENOM" id="CLU_079322_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1075-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="299" mass="32052" checksum="2D4D1380023A1F6E" modified="2010-05-18" version="1">MPHLIVIEGHEGQRRQLEETLTALTREDRQVSGKFDADGTFPDWRALLERVGSRGLFAAREAVVAEGCEALGAFPDGLAGSLEGPEADAVIVATFGGEARKVFSKEVLALKKVRFLKAEASVPPWKRKDWLLKLAQEKGWRLAPDAALLLGESIESTEELRSELAKLALYADGREIALADVRALSFDEGGRALLTFLDGVCAGNAQDVARALSRLSRDPLLPVLTALCNRLRPALYIASFPGNEAQAAAAAGANREYAMRMARGGPAPLRGEGRQGLHAAGRAALLRGEDLRRPGLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y2</accession>
    <name>D4M9Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5, Hmari subtype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17700"/>
    <dbReference type="HOGENOM" id="CLU_090888_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1090-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013421">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_HALMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02592">
        <property type="entry name" value="cas_Cas5h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="241" mass="26501" checksum="ECB6D52D70689D9F" modified="2010-05-18" version="1">MAVMFDCSSDMALFRKPYTTTSSVSFAFPPPSAIAGLVSAIVGLDNGASGDASHAFYWRELAGTRVAVALLRQTRWMRAAVNFWNVKNPQTTPHIQVKHQFVASPRYRVYVAGGVEARLRGHLERGSFIYTPCLGVAYALAQIDYIGACDPQPMGEGEVRVDTVVPWEGEGMELNLAESGGIFSERVPFRLTTERALAESIKVVYSSDVSRPLCVRKRGGLHVTRCAARGVEDVVAWFPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA12</accession>
    <name>D4MA12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18490"/>
    <dbReference type="HOGENOM" id="CLU_1394559_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1120-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="198" mass="22210" checksum="83163AAF5AEB9638" modified="2010-05-18" version="1">MSGERTEGSPPSRLRWYVGVPLGTNPLILLDLSILLTVGWSVSWLSLLALQAGFGGYVDASHVKGAALVSGYLVLAFLGLFGVVCFVVMRNRYAALYRFDEEDAFCDNMRCSPRAADGRRLHFTGYPIDPVLEVIRSTERRARWEDVTTVQPMDAMRVLLLRGRRGVLMRVYCPDDATYDQALLYAETHRKKTDASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA13</accession>
    <name>D4MA13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase class C and other penicillin binding proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1112"/>
    <dbReference type="HOGENOM" id="CLU_020027_0_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1121-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="462" mass="50298" checksum="5C09D684DB63B0B6" modified="2010-05-18" version="1">MSLNSDLERRYEEYLAEVMEVHRARGVAVAVIDRVGRTLWQKLAGYRDAERRLAIDEDTIFGLASLTKSFTALLVTQLAERGSLSLQDPVSVHCPSFRDAGPNPVRLAHLLSHSGGYFPLPRTTLEPVAKELGLPLDGPEDPAFSDELARAGVDRVAGAMSAASERVGEPGEYMSYCNDGYGLLAEVIHRASGAGSYAACVRREVLEPLGMTRSSCEFLRPAQDANVAKLYSEAAPEGDLNFCRNAFVLMGGGAMKSTLADMKKYLRMYLNEGAIDGGGRLASARGVRAMCRPRIPTRSQQFYGYGLSISFLEDVTVIRHGGSLPGVSSHMAWSPELERGVVVLCNTEDVPVSLLADAALRLSMGLDPRPASRWRRCPWTDATLRAACGRYESGEGADVLVERDGEGVAVTNSGKVMEVLMVHPFRAVLRSGLSETEFRLHFGEDGEVWGARLGDRIVKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA15</accession>
    <name>D4MA15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_18540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18540"/>
    <dbReference type="HOGENOM" id="CLU_161929_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1123-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40588">
        <property type="entry name" value="PTHR40588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006156">
        <property type="entry name" value="YafQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00053">
        <property type="entry name" value="TIGR00053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="92" mass="10713" checksum="BE93D676273DAB3E" modified="2010-05-18" version="1">MLKLRFSSKIQKDLKLLLKRDYDLSAFDRVVRLLAQNAALPESLGDHPLKGDWSGFRECHITSDWLLIYRVERDTLTLVLVRTGTHSDLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA49</accession>
    <name>D4MA49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_19060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19060"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1173"/>
    <dbReference type="HOGENOM" id="CLU_308771_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1157-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="955" mass="108734" checksum="09C66A221F3BD3D2" modified="2010-05-18" version="1">MSLPFVSVQGRSPKRFALRCECCTSSERKSKTAQGFFETSQRSKNVFAYVLNGAPGPDCWRRSGTPLPLASILPKELWEKCLYELSIDREGQCLEYSQVPADDLPLRLGYALSDAKECTLFLEWRPETNDCPLLLSPQSVSSENTAFIKEIGQFYKGQKVLLLSLPRLAFLPHHPGWEPSAKPVDSFSNLGGLLRSREWHFRPPQIAFHISETDVRQEDGFLMALDFGTSASILSIVNYDGNPDESQDLFLRDLCPWEHETLVPDLSNMKSEREASWEVIRWEEGNDSTEKRSLNLPPDMLRNRFPLPRRGTPWIPSLFCKVRGYEGQDKIVIGDEALLILEASRHTASERVLHTFVFSPKKSLGLNDDPQSDEDIENYLFALFEMTAHRLSILDGCGKGFRGPLKSLSWSYPVVWLKHQVKKYEECLKKALARSALRNYVANWRPEAILQSRYALDEASAAFVGFLARRFNKMPPVDILSLMGPYRTENDEGDRMERNVLALDFGAGTTDIVWLTLKHETKMGPIVESDIQLYFALDQGGLEITRRIAEILKDRIREHNVNSGMSQEQASHWLRTNLNDPRIDETFLDGDQKQILSRYRRSKISEFFDIAEAAKRHLGENPSFSIDWTPLLSGTPLKAPGDSESLLTQDQLKDIVKKVFRPVFERIAAWSRAKPELDLILVSGRSSALLGLRELLEESIPREKAPVKNDFIWPLEYSFDDRPEDSAKGYLETPAGEQDLQKNMRMEMEAKTVVAEGLLENARKSITFQGNYIRCNPLDTMRRSRCIGILATDDGDRWLPRFRNDFNLLVEADYGNINPEEELPTYVEETNFTSEGKGLYLGINFAGKGNADIIDRPQVFARILLKNAEGTPYRSLKMFFRQKSATELCFNRALLTKENGDTVESVSTHQEGNRLTVENVTAEIRFFSDEKDFRNSGKIHIDGSHPIDRDPGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA50</accession>
    <name>D4MA50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NC domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_19070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19070"/>
    <dbReference type="HOGENOM" id="CLU_1376401_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1158-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="2">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="198" mass="22539" checksum="8A2E0AB8BA80F1F4" modified="2010-05-18" version="1">MVMRNQENLRRLENGDVIRVYRKSFHYDHYGIYVAMDNSVIHYTTPKKEGDGNDSGICGDSCGIVRETSLDEFLDGAESFEVCRYPEEGSWRPLWWARETFEVRRDEVKKNRPPFCEMAQNSPGGQAVQNAKSLLGENKYNLVWNNCEHFAVFCRYNYRASGQVQGWVGAAAVFIAIVVAIPLALLELGKARNEDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA78</accession>
    <name>D4MA78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline-glycine betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_19410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19410"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1205"/>
    <dbReference type="HOGENOM" id="CLU_010118_6_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1187-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="527" mass="57941" checksum="74E1A8ACEC572426" modified="2010-05-18" version="1">MGTQLEDKRMNKAAFWPAIIILALFITSGVIWREPVGNFMTTLLYGMADYLGWYINLLSLAFIILGVVFVAVRYGDVVIGGKDAKPAYSMPIWCAMSICSGIGTGLLFWAMGEPMYHFMTTPTAVGTAGSRDAAIFAVAQAMWDWSFVQYCMYAICGAAFAVICFNRKKSLSFNSIIECAIGKKIPWLNTLLTAVVIFCIMGATSNSMGVGLMQIGAGLEAAFGVPQSRLIWLLAAIFIGCVFITSCVTGISKGLKYVSTCCMYFFFFLMGWVLIFGNTQFISKIGSESIGYIIDNFGKMTVMTNVLTTNDSWFADWIVQYWASFIVYAPVIGMFLARMGRGRTVRTFMLVQILVPSFFCIVWIAIFGGQVIHLQTSEAFDVWNAVNTSGMQATVFQIIGTLPMSNFVTIMFLLCIVMSFSTLADPMASCVATLACRKLEADAEPPMFQKILAGCILCGTAYTLVATGGINSVKGMFTLVGLLQSIILIMCAIVLFKYCKKCYDAYFEGREENGEWGVVENPIDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA85</accession>
    <name>D4MA85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_19530</name>
        <name evidence="2" type="ORF">SY1_22400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19530"/>
    <dbReference type="KEGG" id="sbr:SY1_22400"/>
    <dbReference type="HOGENOM" id="CLU_3412571_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1194-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="28" mass="3052" checksum="120E9818B2EE2800" modified="2010-05-18" version="1">MLREGMSPASVARFTRLSLDEVEALKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA87</accession>
    <name>D4MA87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPFH domain, Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_19550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19550"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1218"/>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1196-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="31"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="272" mass="30360" checksum="F200F67DC6301B91" modified="2010-05-18" version="1">MVLDSSDLAFIFSNLGGLFMAVLLLLFILSFSVRIVPEYRRLVLFRLGRLVGSRGPGIVLLIPLLDRAVTVDLRILTLDVPVQEVITKDNVAIKVNAVVYFRVLDPSKSVVEVENYIVATSQLAQTTLRSVVGSVEMDEVLSSREKINQELQEIIDERTDPWGIKVSAVEVKELELPEGMKRAMARQAEAERERRAKIIAAEGELQAATKLSEAARQMEVSPVTLQLRYLQTIREIAGERNSTTFFPIPIDLLRPFINQAFGGRTQEGPDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA92</accession>
    <name>D4MA92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_19670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19670"/>
    <dbReference type="HOGENOM" id="CLU_2879342_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1201-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="63" mass="6942" checksum="63C13300FE536C92" modified="2010-05-18" version="1">MRVSRVRGLDVRHHPPVEAADQPVLDVLQLRGLPVRTDDDLAVALVERVEGVEELLLTPLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA0</accession>
    <name>D4MAA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_19890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19890"/>
    <dbReference type="HOGENOM" id="CLU_3118146_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1209-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="50" mass="5452" checksum="C7E66AFA084D51BE" modified="2010-05-18" version="1">MEPEVVYFYTDGSCTPARISWADPGTAEGAADRFLLTVTGYCAPVPRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA3</accession>
    <name>D4MAA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19920"/>
    <dbReference type="HOGENOM" id="CLU_2806245_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1212-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="67" mass="6935" checksum="882AE7F7E665E666" modified="2010-05-18" version="1">MTCALMMKGRIRPPFIMAAIVLGPSAVAAVPLLSLPVDPILSGTAVSIACCLAGLIFQPSREVRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC8</accession>
    <name>D4MAC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20480"/>
    <dbReference type="HOGENOM" id="CLU_3233983_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1236-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="43" mass="4925" checksum="F3AB1E073E5028B8" modified="2010-05-18" version="1">MAGRRVDVIAAKFDVQQLVVLQDKYFLDDLQRQLAGLDLYISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD6</accession>
    <name>D4MAD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20650"/>
    <dbReference type="HOGENOM" id="CLU_2879344_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1244-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025459">
        <property type="entry name" value="DUF4279"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14106">
        <property type="entry name" value="DUF4279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="63" mass="6938" checksum="3CF61F5EF655B57B" modified="2010-05-18" version="1">MISMLGSKVEVLQQLVKDYEIDVVFDGIVVMEDGDAPELCFSKETIALLASLNAEFGITLYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE4</accession>
    <name>D4MAE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydrogenases, Fe-only</fullName>
            <ecNumber evidence="8">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_20800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20800"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1339"/>
    <dbReference type="HOGENOM" id="CLU_018240_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1252-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="568" mass="62579" checksum="278C1FEE7A1A0809" modified="2010-05-18" version="1">MGTMIINGRPVEFTDEKNVLAVIHKAGIDMPTLCYYSELSTYGACRMCVVEDARGKIDSSCSMEPRDGLEIRTNTARLLRYRRMILELLLAAHECDCTVCSKSGSCRLQMLAHRYGVKRVRFEDTRERLPQDESSYAIVRNPNKCILCGDCVRVCREIQGMGILDFVNRGSEARVRPAFNEPMIHTRCISCGQCAAVCPTNAIRVRRHIDDVWKAIFDPKKRVVAQIAPAVRVALGERFGLEPGVNSIGKVVAALRTLGFDHVTDTTLGADFTVMEEAAELMQRLEDGGPFPMFTSCCPAWVKYCENCAPDLLKHLSTCRSPMQMFSPVIKAYYAQAEADGRETCSVAIMPCAAKKMEAAREEFRTNGVPDTDYVLTTQELIEMIEEAGIDFDALVDLAPDMPLGLGSGAGVIFGTSGGVAEAVVRRCLNSNKQYLSSEKIEMTSIRGFDNVKEATLTLAGQEIRIAVVHGMKDAQQLIAEIFDGSRSYHLVEVMSCKGGCVGGAGQPYGLTPVKRERASGLYSADKMSGIRSSDENPIITYLYENVVKGRSHEMLHVHHKVPEGEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH2</accession>
    <name>D4MAH2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">SY1_21200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="KEGG" id="sbr:SY1_21200"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1378"/>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="195" mass="21501" checksum="EBDD5218B051AC06" modified="2010-05-18" version="1">MSTYYIPYVIEQTGRGERSYDIYSRLLKDRIVFLGTQVMDDVANSIVAQLLFLESEDPDKDIHLYINSPGGSVTAGMAIYDTMQYIKSPVSTICVGMAASMAAILLSGGARGKRLALPNAEVMIHQPLGGTSGQASDIEIHARNILNTRKRMNAILARHTGQDVEKVAQDTDRDNFMTAQEALDYGLIDRIIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI3</accession>
    <name>D4MAI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_21410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21410"/>
    <dbReference type="HOGENOM" id="CLU_3412572_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1292-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="28" mass="3178" checksum="29407B115A55C551" modified="2010-05-18" version="1">MRERGMSIQDIRELTNLSLEDLESVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL1</accession>
    <name>D4MAL1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">SY1_21930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21930"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1447"/>
    <dbReference type="HOGENOM" id="CLU_089358_1_1_0"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="166" mass="17709" checksum="364519AFD641DE52" modified="2010-05-18" version="1">MRVIEGKLLGTGLSVGIVASRFNELITSRLLDGAKDVLLRHDVSHNAIDVFWVPGAWELPLTVKEIALMGKYDAIIALGAVIRGDTPHFDYVSAEMSKGLAQVGLEQRVPVIFGVLTCDTLDQALLRAGSKAGNKGADCAYGAIEMANLMRTIRTADGTRGGTRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL3</accession>
    <name>D4MAL3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SY1_21960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21960"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1450"/>
    <dbReference type="HOGENOM" id="CLU_036590_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1322-MON"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="301"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBL28908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="371" mass="39999" checksum="8DBF2DCB6ECE6D89" modified="2010-05-18" version="1">MDEIVVNRRVDEYYMRRALSLALRGMGRTSPNPMVGCVLVRDGRILGEGWHRRCGEDHAEVAALKDAERRGETARGAEVYVTLEPCCHFGRTPPCAQRLVREGVSRVVAGTADPNPRVNSGGLAVLREAGVEVSAPCLEEEARRVNKGFIRVQTLGRPWVTLKAASGLDGRMALTDGDSRWITGPEARQWAHGMRASHDAILVGVSTVLKDDPELTVRHTEGKSPLRVILDSHLRTPTSARALRGGCLILTISQEAERARALQAAGARVVPLPSREGRVDLEVALAFLAREGVLTLMVEGGPRVLTALMEGHLADSLSLFVAPRVLGEGIGMGEGFSPASVAESFNLKDVTSRPVGDNLLVEGRFSCSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN5</accession>
    <name>D4MAN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22310"/>
    <dbReference type="HOGENOM" id="CLU_3061828_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1344-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="53" mass="6139" checksum="662F2779BB65BAFB" modified="2010-05-18" version="1">MTVQASIREDLNRRIEELSHDAFYNEHNQKLLLEAINDMKAGKGVTHELINCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS2</accession>
    <name>D4MAS2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_22870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1532"/>
    <dbReference type="HOGENOM" id="CLU_040416_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1383-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="215" mass="23210" checksum="CC3B9FADEF5381BF" modified="2010-05-18" version="1">MTERPVVVPLRVRLASSSPRRRALLSDLGWDLDVLSPDVDESHRPGEGPAELCERLARLKAGACAADSDLPVVAADTVVAIDGLALGKPTDRREACAMLHRLQGRTHEVMTGLAVSWRGRLLSCVERTSVTFRPLSEEAVRAYAASGEGDDKAGAYAIQGRGALLVSEIRGDYFNVVGLPLCRLGQMMESLGFCLNGMLGWDRPGVCVEERSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT2</accession>
    <name>D4MAT2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="11" type="ORF">SY1_23040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23040"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1549"/>
    <dbReference type="HOGENOM" id="CLU_006301_5_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="186"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="7">
        <location>
            <begin position="189"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="241"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="686" mass="73081" checksum="EDCD9226C8F65F8B" modified="2010-05-18" version="1">MAVLEQLGIQIKTHMSSITNEEAQMVESLLAEAEKAKKKPSPASGKAAADGKPAPQAKAEEAKKAAPQEKPATSKADVNGAGEALQKGRRVEVHAGDTIKSTAQAMGISSADAVKALMDSGMMLSAMTAVNDAVLAVFSKKFGVQFEVLPAVKKAEAVFHEKKAGKGAKKHGAANAAARKPGVLTARPPIVTVMGHVDHGKTTLLDSIRHSNVTAQEAGGITQHIGAYVVTHEGRPIVFLDTPGHEAFTAMRARGANVTDIVILVIGADDGVMPQTKEAINHIKAAQVPLVVAINKVDKPTANPDRVRQQLTEQEVFLEGWGGEVGAVEVSAKTGKGIPELLERVLLEAEMQELKGDAGASPEGVVIEAELDKGKGPVATVIVQKGTLQLGDIVLFGTAWGKIRALFDWAGKPTRKVGPSMPAEILGLDEVPQPGETFTVVESEREARTMMAEARARERDEGATTARRTSLDDLYSQLKEGELPQLNLVVKCDVQGSLEALCASLEKLATNEVGVSIIHRGVGRIAESDVMLASTSNAVIVGFNVRPDANAKRAAEADGVEIRTYSVIYDAIDDVKAAMSGLLKPVLREESLGEVEIRETFKVPKAGKIAGCHVMQGLIRRTARVRLVRDGVVLWDGRIATLRHFKDEAREVKAGMDCGVALEGYQDFLVGDLLEVYDVVEEKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU5</accession>
    <name>D4MAU5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_23320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23320"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1573"/>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1406-MON"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="9">
        <location>
            <begin position="77"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)" evidence="8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="413" mass="43869" checksum="F29F909C9C4B39CF" modified="2010-05-18" version="1">MADCLLRCALCGREFNPESRVKTCPDCGIDGTMHVLYDYDEAKKRMGRKELAASFDFSLWRYSALLPVKEGARRPSLHVGWTPIYSVSGIAREYGVREVLVKDDGRNPTASLKDRASCIAVTLALQEGQETVACASTGNAASSLAGFAANVGLRSVIFVPEAAPAAKVTQLLVFGANVFLVGGDYAATVRLAIKAIERWGWYDRNCAINPFLVEGKKTCAMEIAEQCGWDVPDKVFVSVGDGCIISSTYKGFYDLHRVGLIDRVPQVIGVQAEGASPIHRAVQSGARTVVFGPSRTVADSIDVGAPHNWAKALNAVRSSHGDTVAVSDGEILAALAELPRRSGVFAEPAAAAAYAGFVKMAREGRLQASDRIAVIVSGNGLKDVVAAQEAVSPARKIAPDMAALENALGLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX9</accession>
    <name>D4MAX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_23860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23860"/>
    <dbReference type="HOGENOM" id="CLU_1302796_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1441-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="37"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL29024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="253" mass="27368" checksum="41D23E67A738A623" modified="2010-05-18" version="1">MQLERMGRPLGSAAVLLAAFLVATTVAPAWARIDRAVVQRAWERVAAADDFKRIPVTFEKSDKPNAWVKYESAEDFSVHVTQGLMDLLNAEDEIAGVLGHEIGHVRRGHYSDQVSRNVGWAILGSLLGKAGDLAQTAGAIGMSLAESGFSREQEVEADDYGTDLLAKAGYDPHALYRAMKRFKDAGLGTEPNGFNSHPPTDRRLKHLKERADRIAASSGKTSRIPDAAAPPPIRPGQRTTARSSPPPRPSPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY1</accession>
    <name>D4MAY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted hydrolases or acyltransferases (Alpha/beta hydrolase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="9bact-d4may1">
        <property type="family name" value="Haloperoxidase"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23910"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1630"/>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1443-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL29026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="269" mass="30514" checksum="7DAF488BE6AB0CC9" modified="2010-05-18" version="1">MPFTTTNDNVSIHYEVHGQGKPLLFLPGWTCTTHFFCKNVEPLSKDHKVVLMDFRGHGESEKVLYGHRIARYAMDVLNLIEALDLDEVTLVGWSMGAAIAWSYLELFGPRHVEKLVCIDQAPAQYIGPDWTWGQTSCYDAETFVRTCCAAEFLPRTSAEGLVHGCLHREPTVDEVTTLADEISKCPPRVRIEIMRDHTHIDWRDFLPRITVPSLVLVARNSKVFPWQGSAYVGEAIPGAKTVFFESSGHMLFWEEPDRFNEVLSNFLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ6</accession>
    <name>D4MAZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_24120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24120"/>
    <dbReference type="HOGENOM" id="CLU_1452469_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1458-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="186" mass="21134" checksum="813FBF54CCCF9A56" modified="2010-05-18" version="1">MVSHNQRDIVKSPDAQQFTFSTSITNHALFAHFVTFLNLYVFLCRNAEKGYITTKASANIRCTESNSGAKHTGELSVVTATVCGSGLWIGSGRGRYRQCVKFSHQTDSWPVKKTMKVAFNTCDGQVLLRLQSQRPHFFCKLARRPMFLKAQFSMAPEVISKRNKFIAMAIDNLTNPFFYFFHVYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB03</accession>
    <name>D4MB03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type spermidine/putrescine transport systems, ATPase components</fullName>
            <ecNumber evidence="6">3.6.3.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_24190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.30" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24190"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1465-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL29048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="374" mass="40439" checksum="AB385496C35FE7D3" modified="2010-05-18" version="1">MSDTVNAGRKTPRSVTLNGITKVFRDPQSGQDVRAVESVSFRLEPGELVTLLGPSGCGKTTVLRILSGFEQPTSGRILIGEADVTDVPANGRDTAMVFQSYGLFPHMSVFDNVAYGLKLRRVPRAEAAKKVARFLDMVGLGALSKRSPSRLSGGQQQRVALARALIVEPSVLLLDEPLSNLDAVLREQMRVEIRRLQKSLGITAMYVTHDRVEAMSLSDRIIVMRNGRIVQVGTPSEIYRDPANSFVAGFVGRATFFPCRVLGVSGTACVVEVKGHTFEAPRWDPSLRAGDGALLMARPESLSLGEPGTGVEDGVLTANVYLGNSMESWVKTDLGDVLVQIDAPDTRRVWAEGERVSLSLDPLLTKVLPGDEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y3</accession>
    <name>D4M6Y3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">SY1_00260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1725"/>
    <dbReference type="HOGENOM" id="CLU_061463_3_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="103" mass="11565" checksum="948ECC9519EEC973" modified="2010-05-18" version="1">MYAVVETGGKQYRVQEGDRFRVERLDGEAGSEVVFGKVLMVGGDTGVRFGTPYVEGASVRAEVLAQGRGKKVLVFKYKSKKNYRRMQGHRQYFTEVVIRGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z5</accession>
    <name>D4M6Z5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">SY1_00520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00520"/>
    <dbReference type="HOGENOM" id="CLU_075939_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="96"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="216" mass="23491" checksum="A9451C8AE3C765B1" modified="2010-05-18" version="1">MEPREETGKGANGRLRRKGYTPCIFYGPQMEKSVQGKLKTRDVERILATGRWESMRLNVTLPDGTEEMCIIREVQVNPLTDCPLHVDFLRLIKGRKITVNIPIEVLGRESAPGVKDGGVLETLREVEVETLPMNIPDVLTVDVSALQIGDAIHVRDLALPEGVELKADPDEIVAVVVMSRGVGESAAAEGEEPADVEVVAKGKAAREAEGDGEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M718</accession>
    <name>D4M718_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_00930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00930"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.364"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-45-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003060979" evidence="3">
        <location>
            <begin position="22"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="69"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="514" mass="57787" checksum="2692B11B042CB0B4" modified="2010-05-18" version="1">MKKTFALCFALAMLYAGVAFAASRGETLRVGVSIDAKNFDPQNAVDTYSFSMQKQIYEPLFTVDGKTRKLTPVLAEKVEVLDDHTYKFYLRKGVKFHNGEEFTADDVVFSLTRVTDPKSSVFAKSKGVWIDPKGFEVIDKHTVIVRTNGPVGGWLGSMKHPYAMILNRKAVEEAGADYFRKPVGTGPYKFVSWTKGERVEMEAFDDYWGEKPYARKLTFVVLPDDSTRIIALETDKVDMIYAVPPSDFERLQNSDRVKAVKAPGLVLLHLAMNMDSPKLKDSRVRKAIDAAINKEAYVQVVYNGNGIPGEGPLPTASSWFPENPEKWGYDPDLARKLLEEAGVKDLELNLWVMNAADRVNGATVLQSMLGAVGIKVNVSVFENAVISDKVRKEPEKYDMYAATWGMQTNRDAGVYWQSVITTTSIASTNSARISDPEIDNLMDEANHSIDEEKRGQVFQKIWDRVNDLHPWVYLCQADELHGAQKDLIGVDELYDGKINLLTNIHYPEQTERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M724</accession>
    <name>D4M724_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01030"/>
    <dbReference type="HOGENOM" id="CLU_2787845_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-51-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="68" mass="8018" checksum="4FFA0506B507D838" modified="2010-05-18" version="1">MNCDCYELLLRQGDCKSSLNKKTFLEIRKISQFAKIDRGKFRCKVIVHNNDRFVTQAAHADKMREQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M742</accession>
    <name>D4M742_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01240"/>
    <dbReference type="HOGENOM" id="CLU_3420980_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-69-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="24" mass="2842" checksum="C33FFB324CA2105E" modified="2010-05-18" version="1">MGFFGLYPAWKASRLRPIDALRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M746</accession>
    <name>D4M746_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol phosphatase and related hydrolases of the PHP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01360"/>
    <dbReference type="HOGENOM" id="CLU_061999_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-73-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="239" mass="26778" checksum="F9BCBBE3C3F5E23D" modified="2010-05-18" version="1">MMLRADLHTHTIASGHAYSTVGEMARSAAAKGLDLIAITDHAPSMPQTCGWMHFANLHTLPREVCGVTVLRGVELNVRNMEGETDLPERVLRRLDWIIASLHEHVLPSGQETDYTPVYLALAEDPFVDMMGHPESPEYAFDMDRVLPLWAERGKVVEFNEAHIFTGSQKNRRNALRLAEACARWGVTVAVDSDAHSEWDVGCTSKAAEMLTEMGFPEELVLNLSAERVLDFLQNRTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M771</accession>
    <name>D4M771_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidases/acylaminoacyl-peptidases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_01710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.817"/>
    <dbReference type="HOGENOM" id="CLU_008615_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-97-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061820" evidence="2">
        <location>
            <begin position="26"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="422"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="636" mass="72180" checksum="532AE6BE7D923D5C" modified="2010-05-18" version="1">MNVKYLGDLLTLGAALGLLLPFAGAAEAGTKPAPLLPMEDFFRNPESAAYAISPDGRRLAYAKPWKSRMNVFVRDLDSEEERRVTSAEERDVGGFFWKGNDRIVYVQDRGGDENFHVYITNLEGTASRDLTPFEKVRAGVLDDLEDDPRHMLISMNRRDPEVFDVYRCDLDSGELTKLAENPGSVVGWMTDHEGRLRVAIETDGVNTNLLYRTSEDQEFRKLLTTSFKDSFDPILFSYDNRLLYVASNLSRDKEAIYTFDPEANKLLDLVYENDEVDVGGLMHSKKRKIVTGVHYTTDKTRYHYFDEESRKLRTALEAFFPDHEVSVTDMDDEEQRCIVRVWGDRTRGAYYFYDRTNNALKKLADVSPWLKEEDMSPMTPITYRSRDGLTIHGYLTIPTGAVSRDLPLVVIPHGGPSAREYWGFDAEAQFLANRGAAVLQVNFRGSTGYGKKFWTAGFKQWGRAMQDDVTDGVKWAVDQGIADPKRLAIYGGSYGGYAALAGATFTPDLYACAVSYVGPSNLFTLLASIPPYWEPLREMEYEEIGDPSKDKALLEEVSPLFHADRIHIPLMVAQGANDPRVNKAESDQIVEAVRKNGRDVLYMVKENEGHGFHNEENRFDFYRAMEDFFRKHLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M779</accession>
    <name>D4M779_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prepilin-type N-terminal cleavage/methylation domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.827"/>
    <dbReference type="HOGENOM" id="CLU_120517_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-105-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="166" mass="17770" checksum="8FC5122825FD6D26" modified="2010-05-18" version="1">MKMRKGFTLVELLIVIVIIGILAAAMLLSSGSATASAEASNIVSNLRSLKAATMMFYADSMDAIAAVNGLLPGTVTVDALKGYTDNPERFADGKGYLFKSNTNKNWFVGVDLEKLKMSSTMDEVMKKLEGKKDTLALISTTDATSAPANTTPSINTTHKVVWMVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A9</accession>
    <name>D4M7A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-layer homology domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_02280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02280"/>
    <dbReference type="HOGENOM" id="CLU_041895_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-137-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003060986" evidence="2">
        <location>
            <begin position="23"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="503" mass="57263" checksum="449386016F23E44A" modified="2010-05-18" version="1">MKKFAAAIAVAVLFAFAAPVFAATNPFMDVPMNHWAYDAIGQLAAHGILSGYPDGTYKGKQPTTRYEMASALARALAVVDMTKASKQDVEMLKKLVVEFKDELEALGVKVENLDERVSLLEERLGGWHIHARLRLDIENYEDRDAPESENKVYLKQGRLWIERWFGDEENPMHAVIRLDEGTKNWSRFYAEIPFFFETTLTAGRFVWDLEDEYYLGGATSLPETGSFAAYDSILTDRTMDALGLEKQWGMGKFIAYVAHPSNEYYDRGGKAPKTLGAWELFAMGKLQFTERFGFDLGLQAFLGDNAEYIDTASSSGWSFDNLWTIFAGLRFNFNDDIALKGIFYHQQLNGDVWVPGAAGGVWKDADLDSANHWKLIVDVNQEALKFTSLWLEYGQMDKNFIVPAELGGNGALFTTDAFSYVLPDDLKYWRVALGQEWNDKWATHLFYNGYNFDTDVDLTEWGLGVQYTYNPSVKFGLNYVKIDWDDDKKNDDHVLRFRTQVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B4</accession>
    <name>D4M7B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02330"/>
    <dbReference type="HOGENOM" id="CLU_2649229_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-142-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="76" mass="8445" checksum="62E6502515D3CB30" modified="2010-05-18" version="1">MTVAQVAERKALYRRFRNLSDQDAARVLQLIDELEDPEPNEETLAALKESERIAHDPSVKGYSSAAAMMADILADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B6</accession>
    <name>D4M7B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02360"/>
    <dbReference type="HOGENOM" id="CLU_1213373_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-144-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="228" mass="24818" checksum="A614A27FB4ED9D9D" modified="2010-05-18" version="1">MVQRYRNQINEAATPAAFGRNYVDGAATGVNVAGAIAGAGDELRRFAEVRKRQQDEWDAATVMNAQTEYARQMAEWMDDPETGKLQTLKLGAARGLTDETFQYADELAEKIAGGLENENQKAAFLRIAERAKLPYWKQASEYEGEDPPGQPEPLQPLPDRRGQGVQAPAAPRQKRSKMIPDGTPYDPPAPSGHPPCRGGKRVGLRLSPPCRESREGTAGLWGAGCSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D3</accession>
    <name>D4M7D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02610"/>
    <dbReference type="HOGENOM" id="CLU_056607_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-163-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="145" mass="16891" checksum="826666B0FD054BFF" modified="2010-05-18" version="1">MELNTKRFHELTNEELYAILKFRVDVFVVEQNCPYPELDNCDQAAIHVYLKDENGIQAYLRVMDKEIESEYVSIGRVIAAKRRCGLGSQILKEGLLVAQKQFGAKQIYLEAQTYARRFYEKLGFQQISEEFLLDGIPHIKMLLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F2</accession>
    <name>D4M7F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">SY1_02860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1765"/>
    <dbReference type="HOGENOM" id="CLU_069535_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-182-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="253" mass="26761" checksum="BE6AA98D4A01EC7B" modified="2010-05-18" version="1">MPYKVDLNSDLGESFGAWKMGMDEDVLTFVSSANVACGFHAGDPLVMKNTVAAARAAGVAVGAHPGYPDVVGFGRRGMVCSADELYTDVLYQVGALKAFCEAGGLKLQHVKPHGAMYNSAAKKLEEAMAIAQAVKDAGDGIILMGLAGSKFDEAAEKLGIPYAAEAFADRGYMNDGSLVPRRMEGAFVKDVEVAARRVIRMVKEGVVEAVDGTVVRLKPQSICLHGDSPTAVQMARTLRARLEEAGIEIAPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F9</accession>
    <name>D4M7F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_02960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02960"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1775"/>
    <dbReference type="HOGENOM" id="CLU_018808_15_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-189-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="511" mass="55088" checksum="8D6E15E5990059A2" modified="2010-05-18" version="1">MTTGIELYRWGVFAVASAILIAVGWWTNVRLKKKAAMTHLSGDDEKAFLLGSNEMGPFVAAGTLMATGYSGWGFIGSPGTAYAYGTIEILANFLFAPAITFGALFFAGFMRKQGERFGALTVPEYLANTHRGSQGMRRLVHFLAAIATFVFLSVYMIGQIRAVASVASEWLGTSPHMSAIIFMAVVMIFTMQGGLLAVAITDTIMCCGMVIASCIVYYVITQDISLTELIAKVGEIKPEFINPTTSNPYGDPKYSVFLVFVYATLFTTVLPYMSVRFLAMKKDMNIPLVALYMAPMGFAMSFVPLVGLYMFYKDPTWPQALAADAPAGAHIADHAMPVFLNTYLSPAVASIISLFIIFAMLSTISSVLQVQAAALSHDLYVSAAGKESRYADLLDRGTVVVTTVLGIVLTFFAPQGMLNRIAYIGTGGLISMLVGPTIIRTFIEGNLLTCLLSMITGFFGNVYLVLIYGKFGWVEAPIIAGIAGSLVYMIVGYVTNGMRARPLDSEEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J7</accession>
    <name>D4M7J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferases, including N-acetylases of ribosomal proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03660"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1847"/>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-227-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="166" mass="19632" checksum="8994CC4EECED7905" modified="2010-05-18" version="1">MLETERLAIVEAAESDIGWIVAQENDEENRRFIWVGTYEEHLAEIADPGHRLLVIRRKDGVETVGYALARLDFMSERFELRRIVIAQKGRGYGRESMEALMKYAFETLKFNRFWLDVYPDNAVGIKLYESLRLHRDGVLRQNYKSDRGYLDQIIYSMLKEEYFHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K3</accession>
    <name>D4M7K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_03790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03790"/>
    <dbReference type="HOGENOM" id="CLU_046113_1_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-233-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="278" mass="30489" checksum="55569899B5EC31A8" modified="2010-05-18" version="1">MKHCLSRGALSLVAPALFLLFWHYASLRIDNAVVLPKIEDVLAILLHPTKDLLNMGSLVGNVTVSFVRVFGGYLLAVFVAVPLGLAMGYWNWLNRMLGLMAGLFRPIPPLSWIPLVLAWFGVASMATILGIEEGAWYPFFSNIKISMLFIIFIGAFFPILVNTIGGVQSVRVTLIDAVRVLGASPWQVVRYVILPYAAPQVFTGLRVGLGVAWMCLVSAEMMPGSISGVGYLITHAYTVAQTDVVIAGMIAIGVMGILIDSLFILIERRAFQWQSLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K9</accession>
    <name>D4M7K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_03890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1867"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-239-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="116"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="318" mass="34734" checksum="550C3D60900170B1" modified="2010-05-18" version="1">MEPRPNWCPAEAGDGEGFCPEDFRFVERPDEAPFASRPSVNYWQDAWRRLKRNRAALLSAALLAFVAALCVLGPALTPYGHEALNMAEKNLGPSAAHWFGTDKMGRDLFTRVAVGGRVSLIVALVGALIDILVGLLYGGVAAGLGGAVDNAMMRLADVLSSIPYLVLAVLVSLILGRGMASLLIAMTLTGWCNMAYLVRGQVLQIREQEFVLTARALGTSPWRILWKHLIPNIMGVMIVAVTFDIPLFIFGEAFLSYIGLGIQPPMTSWGALASGAQQQMLFYPWQLFFPTLFISLTMLSFQMLGDGLRDALDPRARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L8</accession>
    <name>D4M7L8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="7" type="ORF">SY1_04020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04020"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1883"/>
    <dbReference type="HOGENOM" id="CLU_092227_1_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="176" mass="18650" checksum="944EBDD7FF9E6BF0" modified="2010-05-18" version="1">MPASVKYELVADLKEKLERSNAIFVAEYRGMTVAASTALRARVRAAGGEMKVAKNTLFSIAIKEAGLPELPEDLTKGPNIFTLSYGDPVSVAKVLKECATDKTQKAFVLKGGMLGSTVLDLQQLHALADLPSKDVLIGQVVRTIAAPISGLVNVLSGTVRGLVTCLAQIRDKKDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P0</accession>
    <name>D4M7P0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sodium/glutamate symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sodium-dependent transport of glutamate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1923"/>
    <dbReference type="HOGENOM" id="CLU_040907_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-271-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02062">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004445">
        <property type="entry name" value="GltS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36178">
        <property type="entry name" value="PTHR36178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03616">
        <property type="entry name" value="Glt_symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00210">
        <property type="entry name" value="gltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0915">Sodium</keyword>
    <keyword evidence="1" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1" id="KW-0769">Symport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="413" mass="44318" checksum="21CF9AE800738B28" modified="2010-05-18" version="1">MSFEVVDGVFTISENAVFSTAMACVLLLLGYRVKRKVPFLEKYCIPAPVIGGFLFMFVTFIGHNTGTFAFKFDSAFQSPFMLAFFTTVGLGASFELLKKGGLLLILYWLCAGVISIVQNVIGITVGDAVGLPAPYALLSSAISMIGGHGAAGAYGRTFEELGYAGAMGVGAAAATFGLISGVMVGGPLARRLIVRYNLKPQEDNGSYAEIESINAAEGVKLTGLETIQNVAAIIICMALGMVVSGWIGKLLGMSFPDYVGAMFVAVALRNLNEKFQFYKFSFSLSDKIGDVMLNLYLGLALMTLRLWELMDLMGGMLLIVVAQLVFMCVIAYFVVFRILGSNYDAAVMCAGLCGHGLGATPSAIVNMTAVTEQYGMSRKAFMIVPIVGAFLVDIIYQPQTIYFIKKFVEGITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R4</accession>
    <name>D4M7R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+-dicarboxylate symporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_04850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1977"/>
    <dbReference type="HOGENOM" id="CLU_019375_7_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-296-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="420" mass="43547" checksum="802D7AD2DFDD91C3" modified="2010-05-18" version="1">MSENGGKRKVSLLVKISIGFVLGVLFGFGIGPLLGTSPFLSGWVMPFLDLVGKIFLTLLKMIIVPLVFASLVTGAASVGDTRKLGRIGVKTLALYLVTTAVAIVIGLMLGNVIDPGTGMNIPTGLKAEAREAVPILDVILGIFPSNPLESMVKANMLQIIVFALFFGVSCILAGERGRKIADFFEGVAEVMYAMTHTIMQTAPFGVFALIAVTAAKYGLAILAPFAKVIAAVYLGCVLHAVIVYSGMIAALCRRSPLWFFRGIQEAAITAFATRSSSGTLPITYSNVRSNLGVSEGVSSFVLPLGATINMDGTALYQGVCALFVAQAFNVPLTLQMQIGIVVTATLGSIGTAGVPGSGLIMLTMVLTSVGLPIEGLALVAGIDAILDAARTCLNVIGDTAVCAVVAVSEGEELLGGREQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S1</accession>
    <name>D4M7S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_04960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04960"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1989"/>
    <dbReference type="HOGENOM" id="CLU_079292_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-303-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="242" mass="26368" checksum="59245502ACEE17A2" modified="2010-05-18" version="1">MNAQINGLTASILGGWTAELNVRSVMLRILMSVVLAAIIGCERSSKRHSAGLRTFILVSLTSTTAMLTDLYLCQSAPERFPFISAAAVVGAAMISVNAILFSSRSQIKGLTTAAALWSCGLVGMALGAGLYTVALISFLALFSSLALFPPIETYMKDKSNHFEIHLELKSKGNLQYFVTTVRRLGIRIEDIESNPAYLNSGLSVYTVSLTINSAELKKYKKHSEIIEALRSLEYISHIEEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S4</accession>
    <name>D4M7S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1994"/>
    <dbReference type="HOGENOM" id="CLU_015730_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-306-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="686" mass="77659" checksum="09D79D6E701854E8" modified="2010-05-18" version="1">MTPAPNARPAWRRSALWRRCLFLSLIVVPSVLAADYMSALLPHQGGAPVELLLCALFGVLFAWISTGFWTALFGFFVLLFRYQGYRIIDPDAPLPDLPQDVRTAVLIPIYNEDPKNVGAGVEAMWRSLSATGQEGRFDVFILSDTTDPDVWVREEEAWYGLRERLGMDGHLFYRRRPSNVKRKSGNVANFCRRWGRNYRYMIVLDADSVMAGTTWVRMVDAMERNPRIGILQTPPRGVNRETLIARVQQFANSLYGPVFAAGQNFWQLGDAQYWGHNAVIRVEPFMRYCELPKLPGRGPLSGEILSHDFVESALMRRAGYEVWLAYGVDGSYEETPPTLIDELKRDRRWCQGNLQHLRLIFTYGFFPTHRALFLNGILSYGSALLWLIFLIASSIQALLDVLVEPNYFPQPNMLFPQWHVWYPEWALTLLSCTALLLFLPKLLCLIHALLIARSARRYGGALRVLLGVAGETILSMLLAPIRMICHSRFVVVTLLGWGTGWGGQSRDDRGTTWGEAVRAHWWAVLIGLTWGWLLHRVTPSFFLWLLPVVLPLALSVPLSVFTSRASLGRAAARLGLFAIPEELHAPRELTDKAEALAERRRYSPLGISQEEGFRRAVADPHTNALHLAMNRRLRGALNPALVDRALSGEALSQKEKMALLNSPDSMRELHRKVWTLPERQGAPWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T1</accession>
    <name>D4M7T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05130"/>
    <dbReference type="HOGENOM" id="CLU_3418928_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-313-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="25" mass="2755" checksum="EC6B4815F6BC5264" modified="2010-05-18" version="1">MGKKAGDEVELKTSRLTRYAVESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U1</accession>
    <name>D4M7U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05270"/>
    <dbReference type="HOGENOM" id="CLU_163901_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-323-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="99" mass="11819" checksum="26A6DF5D8789F348" modified="2010-05-18" version="1">MATKRFSRAQLEFLSRMSSYIWWKTRDEAMEYPERILAQMMNIGTLEDTRELEKLFSQDELMEVLEKAEAGQFRPKSWSFWHCRITGKEAPAMPVRELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U5</accession>
    <name>D4M7U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05310"/>
    <dbReference type="HOGENOM" id="CLU_2493384_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-327-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="86" mass="9285" checksum="0E4FA8BE84686A75" modified="2010-05-18" version="1">MNVNGYDRLGQAGLELMQKSMSAAAAAAEDIASGSLNPMDVAKSAMDLGRAKVQMKLGAYLIRTQQELMESTLEVFGVGTKLDRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X8</accession>
    <name>D4M7X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05820"/>
    <dbReference type="HOGENOM" id="CLU_197645_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-360-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="78" mass="9308" checksum="EA5881BCD351B7E3" modified="2010-05-18" version="1">MWDNAFETRWSCVFLAAYVVVMLPVKCFYSTEYVPSWKGLPLFMVGWFWLTVAVMVLILLFYWQAMGREEYRAFGTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D4M813</accession>
    <name>D4M813_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SY1_06350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2121"/>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-395-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="63"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="419"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="516"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="837"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="750"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="773"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBL28008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="881" mass="96434" checksum="F92BC01E5AC33F44" modified="2010-05-18" version="1">MAEKFIYSLKEGKGDQKLLLGGKGANLCQMVQSGLPVPPGFILTTEVCRRYMQDPKIMDAIWDEVKRYVKELEKEAGKGFNDGKNPLLVSVRSGAPISMPGMMETILNLGLNDETVEGLASVSGNRRFAFDSYRRFIQMFGSVVDEVSSDRFEQALSACKKALGVAQDFEIPAEALEKLVAEFKAIYKAATGRDFPTDPWDQLRRAIEAVFRSWNIPRAVTYRKINKIADDLGTAVNVISMVFGNLGDDCGTGVCFTRNPSTGENKLYGEFLINAQGEDVVAGIRTPMPIGQLEGAMPDIYRELCRLTGQLEKSYRDMQDIEFTIERGKLFLLQTRTGKRTAAAAVKVAMDMVGEGLIDTKTAVARVSPEQVEQLLHRQVDKSAPQEVLAVGLPASPGAGVGILVFSADEAEAWAHQDKSVVLARPETCPDDIHGLFASAAVVTSRGGMTSHAAVVARGMGKPAVCGCEEVEIDLAAETLTSRGRTLKKGDTVTVDGSSGRVLLGEAPLIEATFSEDFKKLLGWADEAAEQEVWANADTPEDARRAREFGARGIGLCRTEHMFMATDRLPVMQRLVVADSLEERVEALNKLKVMQKDDFVGIFKAMEGYPVIVRLLDPPLHEFLPKEPALLEELGELEKKGRGTSPEAEKLRRTLNKAHQLHEANPMLGFRGCRLGMVYPEIYEMQINAIFEAVAELTKAGVKVRPEVMIPLVGTRAEMKFFREMADRIAGEVMKASGTDFTYLVGTMIEVPRAALVADQLAEYAQFFSFGTNDLTQTTFGYSRDDAEGKFLFQYIDKGVFKENPFSELDRDGVGALMRIAVEKGRSVAPKLSVGICGEHGGNPSSIAFCHSIHMSYVSCSPFRVPVARVAAAHAAMGTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M814</accession>
    <name>D4M814_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nickel ABC transporter, periplasmic nickel-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06360"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2122"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-396-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015675">
        <property type="term" value="P:nickel cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08489">
        <property type="entry name" value="PBP2_NikA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011980">
        <property type="entry name" value="NikA_ABC_Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02294">
        <property type="entry name" value="nickel_nikA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061176" evidence="1">
        <location>
            <begin position="23"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="68"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="526" mass="57867" checksum="94A4328FAC29D5EE" modified="2010-05-18" version="1">MRRFARWLCALWLLSLCGASGAAETSRLVYSCGSNAGGDLSPHQYSSNQMYAQDMIYEPLVRYAVSGEIEPCLAESWEVSPDGKVYTFHLRRGVTFSDGTPWNARAAKANFDAVMANAGRHEWLGLIGELEGTEAADEHTLRLILKDAYGPTLADLSLIRPLRFLSPAQFGADGGTAKGIKAPVGTGPWVHAEARKGEYDLFKRNESYWGKKPELEEVLVKVVPEGDSRVAALETGDLDLIFGTSGHGAAQISLEAFKRLEATGRFETGVSNPRATRALAINSARGAGRDLAVRRAVQHAIDRDAIIRGVFLEVEPPAPFLFSTAMPYCDAGLAPYEHDLEKAKALLEEAGWKQEGDYRSKDGQELAFDLCFVGNDAEQKTIAEVVQSDLRKAGIRVNLIGEESDAYFKRQRDGEFGMIFNDTWGAPYDPHAMCASMRVPSHADYQAQSGLPMKKELDEKIGLVLRATTDAERSALYRDILTTLHDQAVYFPISYKTLVKVHRKGLVGVGFPAFVDSVPFDTMSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M857</accession>
    <name>D4M857_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_06990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2187"/>
    <dbReference type="HOGENOM" id="CLU_507036_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-440-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="529" mass="57448" checksum="C93C35D68265ECF9" modified="2010-05-18" version="1">MHSIFITGIAVAMVLYITVGVIVGRKVKDINDYYVAGRNAPVLLIVGSLVASFLSTGAFLGDTGEAASGGFIAICIVGLIQACGYIYGANFFGRYIRRSKTLTLPEFYGRRFHSKRMRKLAGITCIIAVSAYMLSATRGITSLMMNITGLPEWASILIAWLSFTIFTIVSGSPGVLVTDTMMFLVFLSAAIITVPSIVMAAGGWYTAIGNLANFQAIPGIISAAGNPDFVAQTGETTLWAITYGIVWMLVVMVSPWQTSRYMMAKNEHTVLRSAIWASMGVITTTIFLYFAAVFVASVKPGLGSDTMIWGAMNLVPTTIGVILLTGILSAGISSASNFLALVGFSFINDILTLDDKPEKEKLKISRIGMFLVSLVVLAMAFFANRIFWIMYFGGTVIAGSWGLVSFAAIWSKRLSEKGAFLSMLLGFIGCFGVRLATSVWGVTVPFFLDSFFVGIYLSIIGMVVGNALAKPTPEEIAERERLFIVPESEKDVVEMRKTMGAYKFHIAFSIFMFALFTFGYLVPYLQAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M876</accession>
    <name>D4M876_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal/vacuolar-type H+-ATPase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_07370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07370"/>
    <dbReference type="HOGENOM" id="CLU_059311_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-459-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_suC/d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="334" mass="37381" checksum="5892303DAD895C5F" modified="2010-05-18" version="1">MSYVYTVARLRGMETHLLDAAFFSRLIDSSTLEDALKALSETSYAQWLTQAGGEDFDKAIDEELLATCRELGQFVPDEGLLTLFRMPYDYHNVKVALKSLFRVRGGDAEGRRHDLLSPLGAFPSEGLVEAIETEEYGRLPYGLGDVVPHCWTLWDQTKNPQAVELLLDHHLFAAMLRIAGGLEMPDVVRWVRHRIDAENLKSAVRLARMRYDAAKGLPFFHEGGFIRAADVARLLGEPQETWGKILSYTDIGAVLDALQESSDVQAALSDVSKALDEYLIRVLERVRYSTSAPANVLLYLLTKEAEARNLRIALVCVAGGLSREFSRRLLSHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M877</accession>
    <name>D4M877_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal/vacuolar-type H+-ATPase subunit F</fullName>
            <ecNumber evidence="4">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_07380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07380"/>
    <dbReference type="HOGENOM" id="CLU_135754_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-460-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="112" mass="12140" checksum="FDF1907ABD6C0E6B" modified="2010-05-18" version="1">MPDNRSLPMAAIGSYEMVLPFQAVGVKTVVLDGEKRGSFEEILEKLARESYAVVFIQEDLFVDFGGKVQEVNDRYPTSVLPIPGPSGTSGAGLESIRSSVEKAVGMDIFAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4M878</accession>
    <name>D4M878_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="7">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpA</name>
        <name evidence="11" type="ORF">SY1_07390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2227"/>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_Xtn" evidence="10">
        <location>
            <begin position="66"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="8">
        <location>
            <begin position="194"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="214"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="574" mass="63552" checksum="742561A558C52F80" modified="2010-05-18" version="1">MLGASMSDVVHVGTAGLVGEIMDMDGDKASIQVYEETSGLKPGEPVVCLGEPLSVELGPGIIEQFYDGIQRPLELIEKAAKSPYISRGISVPAIDHAKKWKFEPRVKVGDTVEAGDVLGVVQETVVVEHRILVPVGMKGTVKSVNGGDHTVLDVVAVLDDDGVKHEVTMLQRWPVRKPRPVSKRLAPNVPMTTGQRVVDTFFPVALGGTACVPGPFGSGKTVIQHQFAKWAQAQIVVYVGCGERGNEMTDVLLEFPELDDPQTGQPLMKRTTLIANTSNMPVAAREASVYTAITIAEYYRDMGYSVALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLGTRLASFYERAGRCVVLGREGREGSITVIGAVSPPGGDLSEPVTQNTLRVTKVFWGLDANLAYQRHFPAINWLNSYSLYTDRLDVYWNEKFDDEWSGLRVEAMSLLEKEAQLNEIVRLVGIDALSRDERMVMETAKSLREDFLHQNAFHEIDTYASMEKQFKMLRMIVRFHHLGLDALHRGAPMNELFNLPVREQIARMRYLEESQISQIDKLEDTMKQQINGIVPVGGEGNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M895</accession>
    <name>D4M895_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_07680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2259"/>
    <dbReference type="HOGENOM" id="CLU_013430_3_6_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-480-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="235"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="307" mass="32322" checksum="F9B9FBE0612C6FD3" modified="2010-05-18" version="1">MTASGETVMKGTRGADAQDERAVVRRLSLTGITGNAALSAFKLFAGVAGRSSAMVSDAAHSLSDVLATLIALVGVLLSKRAADDDHPYGHERFESVAALLLGLILLATGGLIGKAGLEALLSGNDAQRGGPGSIALVAAVVSIAVKEAMYWYTRRCALHLNSAAFMADAWHHRSDALSSIGSLIGIAGAMMGYPALDPAAGVVICLVILTVALRTTRDALGQLLDTSCGRSYDRELADFIAAQEGVVRVDLLRTRRFGNRVYVDLEISVDGDESLRKAHSVAERVHLSVEQRFPGVKHIMIHVNPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A5</accession>
    <name>D4M8A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA segregation ATPase FtsK/SpoIIIE and related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_07810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2273"/>
    <dbReference type="HOGENOM" id="CLU_283394_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-490-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="860"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="933"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="880"/>
            <end position="887"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1099" mass="120907" checksum="D3B5D2D4DE90F3CF" modified="2010-05-18" version="1">MDSLNDSVIRSQLVAKNPFASSAAPNPWDNANPDLDSLNRTVVDHIDLLLKMTRENPAETFAGLILGEAGAGKTHMLKRVLRRIRESGEIAIFVTVRAFMDPESVLQDLLREVFISMGREHGDGKLQIDLLLEALDKAYRRDFREDALGGMARLEPLQMKLDRVNNDFLRCLLLYASTEDASLKNDILRWMRGESDESFSEKLDVIACNWDEMTPAAQEKKARDRLLSLGHVLRYVRVPMLVCFDQLDGMTSEDLLNAWGTAASLLINDVYGVLPLAFLRADTWEQRFSPRLDDAVRQKFLNHRLPMANCNLEQAKQLIKERIKAFFDDDDEVEQKYQWLMARLNTTLKPGYSPRMVITLANQAIQEAGAGADAAHEVEHALAEAYREECDKVASDPNSWPPNANHLLSALEMWLGAHPEFKVSRSADKYLRLSGKRSAEGPEAPCAFIIMATRHHRSAAAAIDRGIKFLEENPNGFCCYVTDERALKGPENWKQVHELLGQFRALKGRTVVLQPDGRAAWYGLVAFQNKVCNGDVTLYPPSGGPRLATPEDLSGYMKEGFRWNLLGLDGESGKPGDGDRSKDTGSGKDPTPSTSGPKDTSGSASEEKRLPLPVAVNSELCQQRPQNGDCSNDLGVAPAPQTVPEKSGSESGDKARDDFGEVHQEIFCHNDLGAAPTPQTVPEKSGSESGDKARDDFGEVPQEIFCRNDLGAAPTPQTVPEKSGSESGDKARDDFGEVPQEIFCHAEGLDRMVQLLKALKDLGLSVADAGVVCGPRFIRLKVLPDAARGTTVKKIDNRADDLQVQMALPVPPVIQAYGGYVGVDVPRSSPQALSLKTLLRQGEESRPRSEAVFPLGMRVDGSVFWADLAEPSMTSILIGGTSGSGKSVLLRSVVVGLLLCAPKDSVNFTLIDPKRLTFVDLAGLRALEEGRILCDVEETMEALKEAVEEMERRYELMEGAKVSHLTDYNAVAEERLRRRVLIIDEYADLMMHKETAKDLEHFIQRLCQKGRAAGFHLLLATQRPDAKVVTGVIKANLQLRVALKVASKSNSQIILGEGFTQAQHLLGHGDMLVGNGSAVERLQGPIADISLLGPEFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A6</accession>
    <name>D4M8A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_07820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07820"/>
    <dbReference type="HOGENOM" id="CLU_962265_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-494-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="289" mass="32205" checksum="C6ABE7A24FD5A2A3" modified="2010-05-18" version="1">MKKLQTGNVVIVVLVLGILAAGAYFLMGSGLFISTPAVASMTPEELAAENEALMKQFQEAGRSIGGMAVLGRSKAALEWLEKYAPDGHPTPLPDDPKAANEGLKKRVADAKVIFEAMQAAEKRENPWLRQYYGEENEQTLKKLGIKSLKVKEAQDDEIKKFLKPARTTAKALKGFLLKHGREIAQDKNYNLASVLDTPEHILGVVKPYLEEDVDYNDSRFSFHGDNKEWWVGYKLDGLSDELRQKIVEGNIGLYRDLYKAPDKGKYLMDINALYDGGDIVFLNVNSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D1</accession>
    <name>D4M8D1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">SY1_08170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="KEGG" id="sbr:SY1_08170"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.17"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_0"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="381"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="536" mass="59565" checksum="135F4D4A585ECA5B" modified="2010-05-18" version="1">MVKYVFITGGVVSSLGKGITAGSVGTLLKKRGLKVSILKVDPYLNVDAGTMNPFQHGEVFVTDDGAETDLDLGHYERFIDETLSEQNTITTGKIYSSVIARERRGDYLGGTVQVIPHITNDIQERLVRAGEGLDVLIVEIGGTVGDIESQPFLEAIRQMANRVGRENVVYCHVTLIPWLEAAQELKTKPTQHSVQELRRIGILPNLLVCRTSHPMDQGMKNKIALFCTVPSEAVIEVMDEPTIYNVPMALHRQRLDDLILRYLELPCDAEPDLSDWSRVVDRFMNPQESVDIALVGKYVQHKDAYLSVVEALHHAGIHHDVRVKVHSVEAEDLDSCDLAGVLGSMDGILIPGGFGPRGVEGMIRAIQYARENRVPLLGICLGMQMMVVEYARNVCHLHGAHSKEMDPSTLHPVIHLMEEQRNIDRLGGTMRLGAYPCDLTEGTLAARAYGTLHISERHRHRYEFNNAYRERLEGAGLKVAGVCPKQDLVELVELPGHPWFVGGQFHGELKSRPIRPHPLFAGFVGMALERQRADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D2</accession>
    <name>D4M8D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">SY1_08190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08190"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.19"/>
    <dbReference type="HOGENOM" id="CLU_016377_4_3_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="217"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="333"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="345"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="583" mass="64337" checksum="9DB40E496B466F8B" modified="2010-05-18" version="1">MVKVLDEKAATPRRRGRPPRVKEPAEALEEVKATQPEEAEGSSPAEESAVVKVRRPRGRPPKNAAKKIEEAETSQQLLLLPDARRVEAVEPSEASKPEVPAPDEPVDEMEETTAYGAEPDSASEAQVVQPVEDGESPAPLEPAPDEPAEARAPYARASVHEVTPHPKPKHTYSYLAAQTLTDLRKIGREFNVAGPTTMHKDDLIISILKAQAESMNYRFGGGTLEILPEGFGFLRPKGMLPTDNDVYLSLSQIRRFGLRNGDVIWGLIRPPRDQEHYEALLRVETVNFSDPESSRHRPMFAHLTPIFPNVRINLDSGPGDWATRLVDMFAPIGLGQRALIVSPPKAGKTTLLKRIAKAISANSPDIILMALLIDERPEEVTDISRSIDGEVIASTFDRPADEHIRVANLAIEKAKRLVEAKRDVVILLDSITRLARASNLTVPPSGRTLSGGLDPSGLYFPKRFFGAARNFEEGGSLTIIGTALTDTGSRMDDVIYEEFKGTGNMELHLSRKLAEQRIFPAIDITRSGTRREELLIPEDELARLWALRKRIVGVDEAGALNLILDKLKQTKDNHEFLMSIKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D5</accession>
    <name>D4M8D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar biosynthesis pathway, component FliR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_08240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08240"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.23"/>
    <dbReference type="HOGENOM" id="CLU_063626_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-524-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="264" mass="28749" checksum="9A0E0B8FE268DBA7" modified="2010-05-18" version="1">MRGIELPAQLLIVCLLLHLRFVGLVFSAPVFTSVMAPTPVRYLFAALLTFSAAGGLGGAEVPLFYFDSVFSIALLGVREVLIGVALGFLSALPLVALRVAGEQVGTVIGFSMAQVLDPTTQTESSIIGQLEFLVGLWFYYHWNGHLLMIQAVMESVRLAPVGRLLPFPPDLIEVGTWLQDLFILAMRITLPFFCSLVLADVGLGFLARTVPQMNIFVLGLPIKVALGFMVLAAVLPLTVDLIYTQFERWIEFALEGVLPWSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E9</accession>
    <name>D4M8E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_08470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08470"/>
    <dbReference type="HOGENOM" id="CLU_1903635_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-542-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="133" mass="15140" checksum="1709139E52B4F760" modified="2010-05-18" version="1">MTIDALRESASRAGRARRTEVDPEVHRSKEAGRLRESCQQFESILWAKLWKEMRNTARSFTTSKDRPWKQMEDLSLEMACDELVERSGGAGLWKMLYDSMIERVAAEQERERADGEGQDAGDAEAPVSFDARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8F9</accession>
    <name>D4M8F9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">SY1_08640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08640"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.60"/>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="261" mass="28115" checksum="C1AFEA39DB1EAA10" modified="2010-05-18" version="1">MLHLKTPEEIDLLRKAGRVVADILDHIGTVVRPGVSTGELDRIADEHISACGGTAAFKGYRMTSRTPPFPGIVCASINDEIVHGIPSDERKLEEGDILSIDVGVCLNGYFGDAACTYPVGAISPERQRLLEVTETSLNRAIEAARVGKTVGDIGYAVESYAVPLKYGIVRDYTGHGVGRKLHEAPQVPNFGRPGRGVMLQRGLTLAIEPMIMSGREAVRVGENGWTVLTADGSDAAHFERSIVVLDDGPEILTPWTSRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H9</accession>
    <name>D4M8H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe2+/Zn2+ uptake regulation proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_08930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08930"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.92"/>
    <dbReference type="HOGENOM" id="CLU_096072_4_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-572-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="142" mass="16244" checksum="EC6EE513C0048DB3" modified="2010-05-18" version="1">MTKYASGILDIVSRPGGHLTAEQIFWEMKRRHPAIVMATVYNNLNALCAQGAIRRLRLEGQPDRYDRTIRHDHMICRRCGELTDVFIGDLTDRLRAETGLEVDFYELKISWICKKCREKEASAEREERSDSTGRERGAGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J8</accession>
    <name>D4M8J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09260"/>
    <dbReference type="HOGENOM" id="CLU_2493385_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-591-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="86" mass="8950" checksum="E2CD03FD66132F16" modified="2010-05-18" version="1">MEWIKAPADTPVCPEKNILLKDIVQLILDGAETPEAVMAELELTGTEEGTDQIPAILDVFVPVVNAWQTGICSGGCSGCSGGCCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8L6</accession>
    <name>D4M8L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type transport system involved in Fe-S cluster assembly, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.160"/>
    <dbReference type="HOGENOM" id="CLU_908343_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-610-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="308" mass="33473" checksum="FE6DC644C22AB60A" modified="2010-05-18" version="1">MEKLTEVQKRLLREVADLHDVPMGAYNVRANGGLAGRNNTANIDIVSKEDGSGIDIHIKPGTRRESVHIPVVLSQSGLKETVYNDFFVGEGSDVTIVAGCGIDNCGVQDSEHDGVHRFYVGKNAKVKYVEKHYGSGDGTGKRILNPVTEVYMEEGSSVEMEMAQIKGVDSTNRTTLAELKKDARLVVRERLMTHGEQHAVSTYKVTLQEEGGSADVVSRSIARDRSYQRFDACIVGNAPCKGHTECDSIIMDEGTILAVPSLEAHHVDASLVHEAAIGKIAGEQLIKLMTLGLTEQQAEEEIINGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N1</accession>
    <name>D4M8N1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_09840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
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            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|651822.3.peg.185"/>
    <dbReference type="HOGENOM" id="CLU_006855_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-625-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="460" mass="49766" checksum="F02A1FE8977DB46E" modified="2010-05-18" version="1">MENGKKRETLGSRLGFIFLSAGCAIGLGNVWRFPFITGQYGGAAFVLMYVAFLLLLGIPVMVMEFAVGRASQKSSTRSFKVLCPERRVWGLWGYGAWIGSVMLMTFYTVVTGWMLAYVWYSASGRFAGATPEAVNDAFGTLLSAPKELLGWTALTSLIGAAVCWTGLRQSVERVTKVMMCGLLAIMIALALRSVTLPGAECGLEFYLKPNFANLTANGLWSSVYAALGQAFFTLSLGIGCMAIFGSYIGKDRSLTGEALLVTALDTAVALCAGLIIFPACFAYGVNPGAGPGLIFVTLPNMFNQMPSGQLWSTLFFLFMSFAALSTVIAVFENIIAGLMDRLGWNRQAAALFTGVAILLLSIPCALGFNRWSGFQPLGAGSGVLDLEDFIVSNNLLPLGSLVYLLFCVSRWGWGWDGFIQEADAGRGIKFPAFLRPYFTWVVPLLVLSIFAAGYWEKFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N2</accession>
    <name>D4M8N2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_09850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.186"/>
    <dbReference type="HOGENOM" id="CLU_006855_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-626-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="462" mass="49805" checksum="E4DF601CD149ED1A" modified="2010-05-18" version="1">MMEMTEKKRETLGSRLGFIFLSAGCAIGLGNVWRFPFITGRYGGAAFVLIYIVCLLALALPLLVMEFAVGRASQRSVVTSFAALCPRHRAWSVWGYAGWIGCTLLMMFYTVVTGWMLAYTCYSARGDLAGLTPDQVGGAFASLLADPAAMVRWLALAVGVSAAVCCSGLRRGVERAAKAIMASLLVIMVALAIRSVTLPGAERGLEFYLKPNFANLTANGLWTTVYAALGQAFFTLGLGVGSMAIFGSYIGKDRSLMGEALLISTLDTSVALCAGLIIFPACFAYGIEPGAGPGLIFVTLPNMFNQMPSGQLWSTLFFLFMSFAALSTVIAVFENILACFMDKLGWSRPLAALVTGCGLFVLALPCALGFNRWSGFQPLGAGSGVLDLEDFLLSYNLLPIGAIVYVTFCVSRYGWGWDAFIREVNTGQGVKFPTFLRGYLTYVAPVIVLLVFLAGYWEKFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N3</accession>
    <name>D4M8N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I restriction-modification system methyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32614">
        <property type="entry name" value="SbaSGP1ORF9870P"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.188"/>
    <dbReference type="HOGENOM" id="CLU_015410_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-627-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="305"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="825" mass="92589" checksum="780CDC9B1F87DEFA" modified="2010-05-18" version="1">MAKKEVRTDLWVAKQLDECGINFDAQGSNIKEINEALKTASKRGTGNVGYPEYVAVIGDFVLVIEDKADTDKQLKLTDKKIIDTDTKSITEYAVNGAYFYGKHIAQNSSFKKVFALGVSGDEKHHVITPLYVDDREGYKQLPDIESFVWFSPSNIGEYYTRYVLEEATDVEKTTEQILKDAAELHEYLRTYGTLKDQDKPLVVAGILLALDEVKHEEFKIDNLTGSQVDKNHDGDKLMKAINTRLTRSNVGPDAKKDKLLSEFSILNTSFRLNEVNDVLGKTPLKFYTKFLYDRVFRNIKYQKTSEDFIGRFYGEFMSYSGGDGQTLGIILTPRHITDLMCDLVDVQVNDVVLDPTCGTAGFLISAMHKMLSMSDSDAQRKDIKKKQLHGFELQSNMFAVAAANMILRHDGNSNLECTDFLKKNPAQVQMKGATIGLMNPPYSQGTKADPSQYELSFVEHLLDSLTEGGRAAVIVPQSSMTGKSAEEKVFKESILKNHTLEGVITCNTETFYGVGTNPVIALFTAHEPHPEDKVCKFIDFRNDGFETRAHVGLVEGDSAKDKKQHLLDVWNGRIEAPSKFCVKTTVEASDEWLHSFYYFNDEIPTDADFEKTIGDYLTFEFSMVMQNREYLFEDTKGRDDDELGDYVEIPSLEEKEWEAFSVDSLFPTIEPTKGKTTSGLVDGEGLPYIAAAKSIIGCQICSKVANNEWASKGNGMVFVQLGDGAAGLAHYVPMPFVGMSGKTSVGYSKHQNLYNGLFIARCLSSNKAIFSHGHSWTGRRLTKTKVMLPVNNDGEPDYDYMEQYSKNMMLHKYKQYLRFIDGKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W9</accession>
    <name>D4M8W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAP-type C4-dicarboxylate transport system, small permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_11380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11380"/>
    <dbReference type="HOGENOM" id="CLU_086356_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-720-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="183" mass="21131" checksum="DA13CF906E1A0A5D" modified="2010-05-18" version="1">MTLKKFLNNFEEYFCVWTLAIMTIVVFVQVVMRYVFANSLSWSEELARFIFLWFSWVGASYAVRERSHFRVEMLVDLFKGASRIWIEYLVLLIWFAFSFFLTWYGTKLVLFIRGAGQVSAAMRMPMTWPYAAVPAGCALMCVRLIVEIWKLHKNGLSHAESGEVRATELKPSGDTTEPLEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X8</accession>
    <name>D4M8X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11480"/>
    <dbReference type="HOGENOM" id="CLU_1298282_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-729-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="212" mass="24069" checksum="5773F8378B4756F2" modified="2010-05-18" version="1">MDELRAYAVLGVPGDSPFTAVHQAYCLLCCLYSAENDPSPEAAMKYQEVRTAYAVLKEKFENKSISTQRNHDVSVPQGSFSADAIANLIFFEARREKEEKRRRRIRLLGAVGGSLLFPILSGSGMYLLFGLLSIPATYLLCSFLEQNDILSQRGTDEAFFSLPCLSWFLWHLFVSFEAYRGDASFLLVVKLIGRQTYFIMIAYFLSLWLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z0</accession>
    <name>D4M8Z0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_11730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11730"/>
    <dbReference type="HOGENOM" id="CLU_038944_7_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-743-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="225" mass="24119" checksum="F0866C641A616D72" modified="2010-05-18" version="1">MGRCGKPLVFLGIAIVAFILNRHYGWSDFLSGPGGLEAMREAVRGNVLTASLIYVAATTVGCVLLALPGVTFAIVAGLLFGPLLGTALCLAAATIGAVLAFLAGRYFLRDAVAPWVERNRYLKRVLFEDVGRSGVVLLMITRLVPLFPYNLQNFAYGITGIGFWPYTLYTALFLAPGVTFFTLGAAGLGDAENRRFYLILAGALAVLVTAAGLYLRRRYVEKSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z4</accession>
    <name>D4M8Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese-related sulfurtransferase</fullName>
            <ecNumber evidence="4">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_11770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11770"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.412"/>
    <dbReference type="HOGENOM" id="CLU_031618_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-747-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061027" evidence="2">
        <location>
            <begin position="22"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="181"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="342"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="470" mass="51786" checksum="F189615879CB1861" modified="2010-05-18" version="1">MRKFLCFACLASLMLPAACWGADFPKASTEDVVALVGKGGGVLLDARHPDIFNGWALDGLPRGGHIEGATDFAYTFLTCGYDEKGNLEKKTRDEVLSDTLARKGLTPGKRVIVYDTDGKDAPLVADYLRSRGFEDVSLYDAKPWIDDESRELVSWPAYELLVPAEIVEKIAAGNVPAGFTPAREIKIFDVNWGDEEGSGYLKGHVPTAVHINTDSIEPPQVFDEKQRRWVSEEESDSVKKLWKLPDDATLLKLLLDNGITADTCVICTGSEPMAAARFAVVCRYMGVKDVRLMNMGLEGWRLAGYALATDSVKPVPVSDFGERAPESKAWIESIDEVAKKLGTEGFTLVDNRTREEFLGKTSGYSYHNIAGRIEGAVYGCAGELSSSSMYYYRNIDKSMRNGDEILALWKELGIDTGNHLSFMCGSGWRVSEILWYARVMGLNDTSIYSDGWIGWSDEGRPFVTGEPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M901</accession>
    <name>D4M901_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATP-binding protein, PAAT family (TC 3.A.1.3.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.422"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-754-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="246" mass="27892" checksum="AFE2792647FAC376" modified="2010-05-18" version="1">MIEIRGVKKSFGSLDVLRGIDLDIDRGEVVSIIGPSGTGKSTFLRCLNYLEEPEAGTVIFGDGKVFDFSRFENKLICELRSHSSMVFQNFSLFANLTAGENIALHLQKVKKWKYDKVTERVTELLRMMGLEDKADSYPRQLSGGQQQRIAIARAMAIEPEIMLFDEPTSSLDPELVKYVLGVIRRLADCRQTMLIVTHEMKFAQEVSDRVIFMDGGRVLEAGSPDDIFERPKHDRIKEFLDLVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M908</accession>
    <name>D4M908_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11950"/>
    <dbReference type="HOGENOM" id="CLU_134846_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-761-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025531">
        <property type="entry name" value="DUF4418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14387">
        <property type="entry name" value="DUF4418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="133" mass="13742" checksum="0F4E3B13CD540C40" modified="2010-05-18" version="1">MKKGNVFAAVIVVIGILIAVLPTWGPAAVCPLPDGGRWMKCHWMGMAELGVGALAALLGVLMFLQKDKGVRRGLSQALAGLSLLAAALPGGLIGGCKNLQMPCQAVSIPVLYALSAGLLLFALLSLHAAREKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M910</accession>
    <name>D4M910_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type metal ion transport system, periplasmic component/surface antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_11970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11970"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.432"/>
    <dbReference type="HOGENOM" id="CLU_067080_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-763-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061543" evidence="5">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="276" mass="30099" checksum="9F0F46CD32B1F20A" modified="2010-05-18" version="1">MKKKVMASLMALAVVVGLTAECASSEAVKPGEGTTVTIAGTAVSQVFYEAFKDLYESLGYKTKFILFDSNPVCLEACATGETMVSIGQQLKFVHSYNTNNGTNLEMVKPYGMYTGIGLYSEKYDSVDKIPDGAQIAVMNDATNEDVSLKVLQEAGLIKLAGDVEFATVADIVENPKNLEFVEMEQAQTVTALEDMAGACCWFTHMSAAGKNPSVYLVRDNVMINYPMGITVNRTDVESDWAVNMAECLRNADVQAKINEAFPNVFEFYTDDAQVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M931</accession>
    <name>D4M931_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12220"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.463"/>
    <dbReference type="HOGENOM" id="CLU_383002_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-784-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030821">
        <property type="entry name" value="Synergist_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04564">
        <property type="entry name" value="Synergist_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="722" mass="74425" checksum="6C7EE09A945AA1A9" modified="2010-05-18" version="1">MANGDSTMGGIVGQGGEIRNCRAQVVLGADSEFINTLDEDSHHYQTILGGIAGVNGDLIEGCLAEGSIRYVGSDDVVYAGGIVGRGKGGDVVQCVFSGDIGVGNTSWGETDAPSSAGGIAGLGDKNIRSCFARGKVANKLGVSGGLVGHLAHAQKLVRIENSSSACAVSSTSGLAGELAGTASTYGDKYQIVRCLWVSEGENPLGANSPKVELVSCDRVPSDADLPVTVALLPTQLGLTERKRGELSVELYPEVSSQIGNVTFAWSLRESEVGVLKLDEGKTATASMMGLKEGAAEVMAQCGPLVEENVSKPSCLVFVHRVLMEKLSLRPKTLVLRNKNHKENIRTLIDPDKNTVSYPPKWRIEVVAGNSAEADDIELTPADGGFGAAVALVRPVSGAEYRVVAEAVDGSGLSDDVIVTVNYVPPVPGSPDVPVPPVSPDVSPDVPAPVSPDVSPDIKPPLSPDVKPPVSPDITLPDVPDDPETGIAPKLPDGAPAGVGASKPAFYGGSENAALKNAAAALSDSGLKAKDLTFDPDTGVVRLQSRVAREVAREVLPKDVSLKKVRTLPVLSASLPKGATVAAVGLEITGADLMAKKASEVKLLKATGPDTGALLKWSGKPEEFGDGRFTVLDGSGRVVDELQPRSRYVLTVFIGDGGKYDLDGEANGKVVDPLALLSLTGGSAPEHQPGPDSKDGGGGGCNAGLGWLLLLAAAVPVVLRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M938</accession>
    <name>D4M938_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_12320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12320"/>
    <dbReference type="HOGENOM" id="CLU_038034_2_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-791-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061208" evidence="1">
        <location>
            <begin position="27"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="30"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="310" mass="34077" checksum="04D5435D8A9E49F0" modified="2010-05-18" version="1">MFLTRVRRHFCVALSLLLLFAAAAAAAPARIVSLSPVGTEILFDLGLEDRIAGVTEFCDYPPEAKLKPKAGGFTEVNLESLVVMSADLLVLQDLHRQELAPKLEALGIPYYILSQESTEDICRGILELGELCGVQDRAEARVAEIRSRLDALASRLKDLPRPRVLLSVSRELTLDYLETLYVAGPSGNFYNELIRMAGGVNAVEEGPSYVKISQEGVLKIDPEVILDLVGDQSYYHAPDAADPDRVFSSEHLMAPWLRLSDVRAVREGRVHILRGTFLLRPGPRIPQIVEAFARCIHPGALSDDQAPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M942</accession>
    <name>D4M942_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_12410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12410"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-795-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="344"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="418"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="720" mass="77413" checksum="2A05157193603F7D" modified="2010-05-18" version="1">MLKNLRISAKLALGFGLVLSMFAVAAIFSWSSISHVQEEMRYLNKLTDLSTLISDLDDALKIVTNNLSALRLSESKEDLDALKSSLDALRAHPRKVNDLVASEPRMQVLRGGTSTSVQVRTLPELEGYIDAFGRSVAAYETTLRSQQAAMASLTDDLEKTTAVIGTIIEKLSAPKSETTAYDAAGVVRSETNEVGTAEDLRYKLTLFRRQYVYALYKRDVALLEGAATDFDKWAADYEAFRSSASEDWLKDLTASNDGLVRSTRGDMESILKAYREARSAMEDCLKNASGIKDCALSIYSLTDRRVNELMMGSYSALSSALTLLLSLVVLSIVLGAFIAWAIARGISKPLGIVVDLTARAEGGDLTLKREDFPYDGRDELGALGEALMKMIAAQRTAVSEVLTTADQAAAKSVDILDNCKRSLDSATRVKDAVQKAVALMENNSSSLQESNAGTEEMSAASMTSAQAATDCAEFISNMTTVTNKAVDTVQGTIKDMGELQKKTQESGQKLQDLVDSVDKISEFVGVITSIADQTNLLALNAAIEAARAGEAGRGFAVVAESVRKLAEESNRAAGNVRALIETLQGSARETKSASDETATLLSQTMEKGTSAKDSLSEAMEQIDKANDRIQNIAAVAEEQAASSKEIAAGIDNVTKSSSEILEHLEKIAEAMDETTAVSTSTTKESDAQADLVQHVKDAISVFKVADSEDRGRRSRKALHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M954</accession>
    <name>D4M954_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_12700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12700"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.503"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-807-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="30"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="282" mass="30992" checksum="5ED307D95A290E72" modified="2010-05-18" version="1">MQFKRRKTRLVPVPSNAVIPDRDAGRAPILECVNLGITLGGLKAVENFNLTIGRTEIAGLIGPNGAGKTTVFNLLTKVYQPTAGTILLDGQDTNSMSTVQVNRAGIARTFQNIRLFGNLSVADNVKVAMNNDMHYGMWSAVLRLPKFRREERAAHRRALKLLSIFDMQDMADVRAGSLPYGAQRRLEIVRALATNPSLLLLDEPAAGMNPSETVELMESIRKVHDMFQIAIMLIEHDMNLVMNICEGICVLNFGHVIAKGTPEEIQSDPAVIEAYLGRQEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M963</accession>
    <name>D4M963_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Selenium metabolism protein YedF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.519"/>
    <dbReference type="HOGENOM" id="CLU_097491_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-816-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019870">
        <property type="entry name" value="Se_metab_YedF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03527">
        <property type="entry name" value="selenium_YedF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="272" mass="28928" checksum="6D0A5E4E51D7213E" modified="2010-05-18" version="1">MVTVNAFGKSGPEPAAMTKEALEKGADEVRVIVDSPTAAASVRDFLIGAGLRVQLQDDEGQLIVVGEKKKDAAADGPKGETPPPTAQEAKPLEGSPRREPHRAEEPTQTEGPHPKPQVPFRQPPMEGAPGSRRGKRSRSKQKKEPEAVPQKGQELAPPRDDTSLAVLITGDTFGRGSEELGGVLVKSFLKTLAGLETPPTVLALMNGGVKLALFDSSTCDRLKDLERRGTRVLVCGTCTNFYGVTDSVGVGIISNMYEIVETIARAGRILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4M979</accession>
    <name>D4M979_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">htpG</name>
        <name evidence="7" type="ORF">SY1_13160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13160"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.545"/>
    <dbReference type="HOGENOM" id="CLU_006684_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="5">
        <location>
            <begin position="549"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="626" mass="70913" checksum="46D092A0C4BABF04" modified="2010-05-18" version="1">MAEETFQFQSEAAELLRMMIHSVYSNRDIFLRELISNASDALDKRRIERLKDSELADFKGEIRVILDREKRTLTVADNGIGMTRDEVVRYLGTIAKSGTREFLAAAKEDSAAGERMIGQFGVGFYSAFMAADRVEVVTRKLGESAACRFNSAGEGEFSVADASRDECGTSVTLWLRPVKEGEKDYSEEWTVRDVIRQYSDFIAWPVVMPVVRKKDGKETVEDEVLNSQKAIWRREEGEVTEEEYREFYRHLTHDWKEPLAHMRLNAEGATSFKGLLFVPAEAPLDLFMNPKAGGISLYINRVFIMNDCQALIPEYMRFMRGVVDSDDLPLNISREILQEDPITRIIRRSTQRKVFSELKKMLESDREKYERFWNAFGRILKEGVIQDHEHAATILDLALFHTTAQEGATTLEEYRKRMQPEQKGIYCLTGRSLSALKASPKLEPFAAKGLEVLLMTDPVDEVILAEGAETDSVKLLNAGLDADVPESGEEKERREEELKGMEADFAPLKDQAMAAMSDRLQEVRPSLSLTNSPACLRDANGLSFQMEQLMRAMGQTPPAQKRVLELNVGHPLIKRLMELAKQKAPETADLLSIFYDQSLILEGVPVEDPASFVRRVNEVMARLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B9</accession>
    <name>D4M9B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_13810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13810"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-875-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="200" mass="21295" checksum="7EEF66B22D58CBC3" modified="2010-05-18" version="1">MRDVEVRGLSKSFGGRVLFRRLNLTFRAGEITVLAGENGVGKTTLLRMMLGLERPDSGEISGLPDARSALFQEDRLLPDLSAARNVALGCRRPPPREDVLRALDAVGLRESADVPARELSGGMARRAALVRALMAPGELVLLDEPFSGLDWVNLHRAAAFIRAARAGRTLIAVVHGVDAEAALGGRLLRLEPSGAAEGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C1</accession>
    <name>D4M9C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar biosynthetic protein FliS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_13850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.622"/>
    <dbReference type="HOGENOM" id="CLU_080373_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-877-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="183" mass="20119" checksum="8271F7418BDD44FF" modified="2010-05-18" version="1">MENRNNAHFAYQATQISTATKEQLLLITYDIGIKACRMAEAALTGEESEKDLSAANREIIRAQEVIRELMVTLNTERGGEMAQGLMRLYDYMYQLLVDANVKKEPENLRTVRTMLEELKTAWEGALVKLLQEYQAAHPEDEDLKNALAELQGTGASGAETPARPGTAPTTLPPRKAGGVNLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F0</accession>
    <name>D4M9F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">SY1_14570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.695"/>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="216"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="405" mass="43133" checksum="F772F02962133BCA" modified="2010-05-18" version="1">MDQGQMFELSDDAIKQRENIIVIGVGGGGGNALNHIIESGLEGVEFIAANTDAKALALNRAPKNNHIILGEKRTGGLGAGANPEVGMEAAKESLECIKEHIEGAHMLFVTAGMGGGTGTGAAPVIAAAAKESGALVVGVVTLPFNFEMQKRFKTAQGGIENLKKCVDALLIVENDRLLQLGNAEKMLLTEAYAMVDEVLYQAVKGVTDLITQPGFINLDFADVRTVMSNAGTAIMGIGESDGDNRAEQAARAAIKSPLMSVPMEGAKGVLFNVTTGPDITLMEMSKAAEVVKSTADPEAEVIWGHVIDEKMGGKVRVTLIATGFPEGRALSRKAPSSNRVPEKPAARNEGTQQPSHARTIFGRQERGSFEETRLQSPSEDEMAPFRGLPKMPYDQPAIFRRRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G2</accession>
    <name>D4M9G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_14760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14760"/>
    <dbReference type="HOGENOM" id="CLU_1553068_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-918-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="172" mass="19466" checksum="0FD3FD000E274029" modified="2010-05-18" version="1">MSRKNLYIGIACLCLFLLALWTAKLRNPQKDSTPFRNGREVYETLMSLRPGTSLEKAKTLLGNPDDVSENVLTWFLMDEQGEFAADFNVLTSQDRVIASSYLESAEGKKVASKKYKIFERELRSILGPPREQISDLLSVWVSEKLQFILAVTFDEEISAVTLLLKEPLVEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G6</accession>
    <name>D4M9G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">SY1_14810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.718"/>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="428" mass="44741" checksum="492E60FADF30B3BD" modified="2010-05-18" version="1">MRALIRPRPLAGTVTAPASKSEAHRLLICAALSDRPTRLTLNGTSEDIDATADCLRSLGAEVLHEEGSLVVTPIRRVPDGPLLDCRESGSTLRFLLPVAAALAEEARFTGSGRLPERPIGALQAAMARHGVSFSADRLPFRTSGRLQAGAFDLPGDVSSQYVTGLLLTLPLLSGDSLLTVHPPLRSAAYLDITLAALRRFGVRPREEGGGADLPRRFQLSGPQAFHTPGVLEVGGDWSGAAFFLAAGALTGPVSVRGLDPASPQGDRRILDFLKAFGAEVSLRKDAVTVAPGSLRGLEGCPLDVDATPDLLPVLAATAAWADGRTAFVNGGRLRLKESDRIASTLSLIRSLGGRAEETPEGDGLIVQGGGLVGGTAEGFHDHRIVMAAAVAASRCPQGVTVTDAEACSKSYPAFFEDYARLGGDVHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G8</accession>
    <name>D4M9G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-D-arabinoheptulosonate-7-phosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_14850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.744"/>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-924-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="88"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="339" mass="36799" checksum="4D2167535D03164F" modified="2010-05-18" version="1">MIIILKKDPDPAQLESLVAWLRDKGLQVHTSTGESHIVLGLVGDTAAMDIDLIAALDIVESVRRVQEPYKKANRKFHPKDTVIEVAGRQIGGGTLTIMAGPCSVESEEQILAVAQAVKESGATMLRGGAFKPRTSPYSFQGKGVEGLRLLSLAKKATGLPIVTELMEVHQLEYFDDVDVIQVGARNMQNFNLLKELGKQDKPILLKRGMSGTIEELLMSAEYVMSEGNEKVVLCERGIRTFETATRNTLDLSAIPVLRQQSHLPIIVDPSHATGKANLVPPMALAAVAAGADGLIIEVHNDPQHALCDGSQSLRPEVFDRLARQIKALHAAVQELERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H7</accession>
    <name>D4M9H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_14990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.758"/>
    <dbReference type="HOGENOM" id="CLU_144811_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-934-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="78" mass="8900" checksum="D351D89BA0C38533" modified="2010-05-18" version="1">MLLVRGYQVLISPLLGRNCRFCPTCSQYALIALRDWGLFRGGWLTLRRLLRCGPWSEGGYDPPPRRPRGEGADDNFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I7</accession>
    <name>D4M9I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein involved in formation of curli polymers</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15120"/>
    <dbReference type="HOGENOM" id="CLU_1341619_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-944-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005534">
        <property type="entry name" value="Curli_assmbl/transp-comp_CsgG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03783">
        <property type="entry name" value="CsgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061757" evidence="1">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="204" mass="21312" checksum="59BDBFF4452D402E" modified="2010-05-18" version="1">MRRNRNLRPLILTGLLVGALAAGAEARPTLAVREFTNKAGGSVPASAITEMMTTELFEAGLFTLVEREKLNYVGEEIRLGQSGLMDESTAPELGKIKGARYSMTGAVTEYHYKAAGGAVPIPGVGGVGGASNTAYVTLDIRLIDNQTSEVVYAAAERGASNQTLGGLVTKYGGFGAGKINGILAAATRKAVVKHVEAMRSLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N3</accession>
    <name>D4M9N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15910"/>
    <dbReference type="HOGENOM" id="CLU_1382360_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-990-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="197" mass="21943" checksum="3B512109C8A4737E" modified="2010-05-18" version="1">MNLLDAIPEIGKILDDLISTPEEKREAQLRLREIDVREVEARLGVQKAWLSNQSVFVAGAIPTVLWMVSLVIFFNHILAPLLAHWVQIPTLDLPAWYSQLAGTIVLGLFGKKAWDSSEIHWGGQVVKPAKEKVAAEIEEPKPQGKPSRPKPTPRKAAAKPAESKEEGSPEPKAVSEMSAEEVDARLRQMCEERGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q0</accession>
    <name>D4M9Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16140"/>
    <dbReference type="HOGENOM" id="CLU_121324_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1007-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009363">
        <property type="entry name" value="Phage_Mu_Gp16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06252">
        <property type="entry name" value="DUF1018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="133" mass="15398" checksum="66D4308C2778A3E9" modified="2010-05-18" version="1">MVQVKTITAAQKKIIWSIARKQLGIQRDELYAAIFGMFEAERMSALTYAQAELFIGELRRRAAGLGPDRLTEPQYRKIMAMTRSFGWKPENLSAWLRRVTGVDEVRWLTVEQARNVITGLERILKYNEEHAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S3</accession>
    <name>D4M9S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted nucleotidyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_16480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16480"/>
    <dbReference type="HOGENOM" id="CLU_130257_7_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1030-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="121" mass="13599" checksum="22FDB7CCB1969923" modified="2010-05-18" version="1">MLPSITLESEQGQLTKEHIAALIQPVAKKYGIKAVWIFGSRARGDHRPDSDVDLLIRLDGETVNGFAIGGIYNDLNKAIPNIDVDMIEESALEDRLKNLSRSHVNFKKNVLRERVLLYAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T2</accession>
    <name>D4M9T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16650"/>
    <dbReference type="HOGENOM" id="CLU_3373919_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1039-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="34" mass="3932" checksum="8F024BBFDC0F41F3" modified="2010-05-18" version="1">MFPAQEGDIPGKKRLFQEAFRGLRGANGKRRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U0</accession>
    <name>D4M9U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted RNA binding protein (Contains ribosomal protein S1 domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_16880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16880"/>
    <dbReference type="HOGENOM" id="CLU_128762_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1046-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="146" mass="16168" checksum="47CA83ECF3ADEE00" modified="2010-05-18" version="1">MSEEKREDTSSVRVGDLVDCVVSQIMPYGAFVNLTESGKRGMIHISELSFNFVKKVEDVLSLQQNVKAKVIKIDDKGRIDLSLKKAEERPMVQVPLSRDEKDSFEKKMASFLKVSEAKIADLNSKSSKSGAPRSGRRKPGGGRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U4</accession>
    <name>D4M9U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_17040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17040"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.968"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1050-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="338" mass="37148" checksum="6A853EAAD8E56298" modified="2010-05-18" version="1">MTTTNEKNERDLMLDVRDLTIHYETDSGVVHAVEGLNLQLGRGESLGFVGETGAGKTTTALGIMRLIPNPPGRIKSGEILFEGENLLSKSEAEMRHIRGAKIAMIFQDPMTSLNPVMTVDKQIAEMIRLHRRVSEAEALSQAGDMLELVGIRRERMHDYPHQFSGGMKQRVVIAIALACDPTLLIADEPTTALDVTIQAQVLELMKQLKQKFAASMILITHDLGIVADICDKVAIMYAGRVVEYADKRALYATPLHPYTIGLFNSVPDIDEDIDELPVIPGLMPDPMALPTGCTFHPRCSMAEESCSAVRPQMQELEPGHFVACPVRARMMGCQAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W1</accession>
    <name>D4M9W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_17290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17290"/>
    <dbReference type="HOGENOM" id="CLU_773292_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1068-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025230">
        <property type="entry name" value="DUF4172"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13776">
        <property type="entry name" value="DUF4172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="118"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="358" mass="41056" checksum="4BF2658E8F4A007C" modified="2010-05-18" version="1">MAERQRWFWQQPNWLSTPVFSDETYAFANQLAERERKLLDDMGIELYETTIVQSMTDNLYCSYAIEGEKLDEDLLRSSIMKRLNMDIPDWKPSSMSRTDREDRAVQAALFLLNDRETLSREKLEEAHAMLKTEKRGTWGKFRSTSEYIRDAQQNVVYEAPPAEKVPALMDQFCRWWNDERVTLPASIGAALGHAFFVVIHPFEDGNGRMARLLADKAMAPSMGDPYRPYSMSSVIYQGLSQYYRALDQLPEENGIQRFVMLMAHMQSDVLDKAVIRMKSVKNMEAVISIAEASGTPITPLGRAMLKTMALEPERKIWTPFDASRNVRDAGDEDPWDVWNTLVERGIIQGKNIASPAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z3</accession>
    <name>D4M9Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17890"/>
    <dbReference type="HOGENOM" id="CLU_221226_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1101-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="31" mass="3402" checksum="5917BD35FF8BDD3B" modified="2010-05-18" version="1">MLVRGVPLEQVVDFTGLSLGEVEALRRGMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z7</accession>
    <name>D4M9Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17960"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1061"/>
    <dbReference type="HOGENOM" id="CLU_3343986_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1105-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="37" mass="4030" checksum="C76D2C81CE42638A" modified="2010-05-18" version="1">MADDLVGGAMVNLFLQALNSCFLRSGWLYGLVVELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA01</accession>
    <name>D4MA01_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="9" type="ORF">SY1_18090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1073"/>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="130" mass="14408" checksum="E49ED85E69235E75" modified="2010-05-18" version="1">MNSTFSWGTGRRKNALARVRLCPGSGELKINDRTVEDYFPRLVWQSLATQSLKTAGLEGKVDVFVNASGGGLSGQAGAVRMGIARALIRMNPDLRPVLKKEGFLTRDPRMVERKKFGQKGARGKRQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA05</accession>
    <name>D4MA05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malate/lactate dehydrogenases</fullName>
            <ecNumber evidence="6">1.1.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_18390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1101"/>
    <dbReference type="HOGENOM" id="CLU_045401_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1113-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="5">
        <location>
            <begin position="151"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="319" mass="34697" checksum="82359577FBB02CCB" modified="2010-05-18" version="1">MQGKKRTVGIIGIGHVGAHVAYSLAVQGIADEIILVDRERKKADCEAQDVMDSVCYLPHRVEVRSGDFPDLKDCDVLVNSAGHIQLLATGNKSRLEEMDFTIRAVNGYVDRVMESGFDGVVINVTNPCDVVAWRFAELSGLPRGRVFGTGTGLDTARLRSALARQTGVDHKSICAYVMGEHGASQMVPWSSVSFGGRPLAEWERTDERFRFDREAIRKEARDAGWVVFSGKQCTEYGICSTAARMASVVLLDEKQILPVTTRLEGEYGESGIFIGVPAVVGAGGAEQVVEVPMSAEELAEFKGCCDDVRANMAHALEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA08</accession>
    <name>D4MA08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyl-D-aspartate/D-glutamate deacylase</fullName>
            <ecNumber evidence="2">3.5.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.3" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18430"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1105"/>
    <dbReference type="HOGENOM" id="CLU_016107_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1116-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023100">
        <property type="entry name" value="D-aminoacylase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="46"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="529" mass="57663" checksum="97A788ED72871257" modified="2010-05-18" version="1">MSDFVVTNARICDGSGSAWYRGGVRVRDGVIAEVGRNVAPCGGVTEVDAGDGMLAPGFIDIHSHADFVLPLHPEGENLLLQGVTTIVMGQCGISPAPIVPERVLQLDEYAGVTRSGRKLKWDWQSFGQWLSRLEELPLGINVGSFIGQGTVRLCVMGFASREPSQDELCRMRELVEQGMEEGAFGLTSGLAYPPGIYSSDAELEFVAGGLAKRRGLYLSHMRNQADRSPECVEATINVGRVNRIPVQVVHLKAREGDRPGMAAHLFGIIERARAEGIDVTVDQYPYTAASSTMRSLMPKWVHEGGVAGIVELLSDPVRRRPLHDEMAASERWQKCMEHGDGPRGIVLGQLPGTPQYTGMNLEAVAKDMGTDAVDALLEVILKNRGCDQGVYFTMTEQDVRNVMVNPLVMVGSDGGIALRGEFVHPRYCGTFPRVLGRYARDLKLFSMEEGVRRMTSLPASRLGLTRKGLLRPGMDADMVLFDPGTIADGNDYEHPTDPPVGIESVWVAGRLAAHRGRLTGERAGRVLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA46</accession>
    <name>D4MA46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted exonuclease of the beta-lactamase fold involved in RNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19020"/>
    <dbReference type="HOGENOM" id="CLU_723175_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1154-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="386" mass="42382" checksum="BEBF4815A25392E4" modified="2010-05-18" version="1">MKKKNEKYKMFPIGGGDEIGASCYAVQMGGERVLLDAGIRFGAPFGSFPSLLAFLKKWDMDGLWELSAVIISHAHLDHMGALPTLLDELGTVPVYSSPATLDLMRTYYENFEQRSPASSGRNIAVRLAATDRLIPKPYGTTIQTKELNITLFPAGHIPGAAMTLLEDGERRVLYTGDFCDFAQHTVGAAEFPQTKVDTLICECTCGYRNRSSEGRNNVGLMQRLNALLDEGSLVECRVRSIGRAAELAGVLRECANRGEMPDVDIWVDPDCEAECRVCERWGNPVFKGRVKLSDRMPVRGMRGVRIHASPASCGGRRVEDRELGLFNHAGCSGILNLIAHVRPTKVILVHGSPLTGGVRNIVEEARERFGTCVEVAHSKNGQEMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA65</accession>
    <name>D4MA65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mn-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_19270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19270"/>
    <dbReference type="HOGENOM" id="CLU_069532_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1174-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="130" mass="14460" checksum="CED8650392EA6B4C" modified="2010-05-18" version="1">MDTTAAEVGKTEENYLEAILMIKERQGYVRSVDVAAHLGVAKPSVTYATKRLKERGFVTTDHAGMLVLTDSGMEIADSTYTKHKMLTKFFIYLGVSPEQAMTDACKIEHDISEETFAALCRYAEKIKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA76</accession>
    <name>D4MA76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family</fullName>
            <ecNumber evidence="3">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_19390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1204"/>
    <dbReference type="HOGENOM" id="CLU_087284_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1185-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="178" mass="19052" checksum="99E5E135DD6C016C" modified="2010-05-18" version="1">MADIIMAGFGGQGVLTAGKILIDVAAHEGKNVSWTSSYGAEMRGGTASCSVVISDEEIGSPYPTKLDILLALNEPSYDKFIGQMRDGGTVIVNSSLMSEREYPKNVNVYLIPATDRANAIGNGRAANIVILGAMIKATGLIDHNAFEEGLDRYFSRKGHSNPKNLEAYRIGRDEAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA96</accession>
    <name>D4MA96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19830"/>
    <dbReference type="HOGENOM" id="CLU_2142249_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1205-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="112" mass="12630" checksum="ADC90F91F8208618" modified="2010-05-18" version="1">MSGARRGFTLMEVLVAVAIVGMVVAGGFRLITMSLRSLSEIAAERALTAAAQRIWLRFRTERDMPDSGREEDVEWRTEIDSVPIEDLELPFRRVTVSMGKRSMVIYLPEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA1</accession>
    <name>D4MAA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19900"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1249"/>
    <dbReference type="HOGENOM" id="CLU_111585_5_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1210-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="131" mass="15154" checksum="FD2ECB3D9AB1437E" modified="2010-05-18" version="1">MYQKKLDPDVRCPLEYGLEVFGGKWKSRVICVLNEKKVLRYSQIRSEMANIKDAVLAGTLKELIADDIIRRKSYDEIPPRVEYSLTEKGLSVVPILQSICRWSGVLTREGAENPDTLFKQCQKCDYNRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD2</accession>
    <name>D4MAD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20580"/>
    <dbReference type="HOGENOM" id="CLU_625366_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1240-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="457" mass="52581" checksum="5B3AB0B8D01FEFBD" modified="2010-05-18" version="1">MTKRTFSQALRRGLGSAIVTLKNVENKAAYRDILLRCCLRDISYDWQSEGTRGYYLYEALLTSREPEYYEEAIIEKFFSRCSDGLFYQLSAILYRFAYDGSEDATKALRSKYDYFASKQGRLRDIPYMHEGEQWDDVVCQLMYLDGFSAFKRYAEDVGRILLRDPGNEVIYGGWFEIRARDTFGEKRITAFFERNYERSAAVRALADTLKARIESEESANARDRQENLTVGDLRQIAAQSVASGCPRPREILRHRRAFFLNASDSKVLDLADAISHEEEESIKGLLLAMFWDRSFPLDISLLMDYAQSENELLASSAIDCLKRIRNRKLHDLAFQLLKRKGLSSFALALLKKNYNKADDTLIAELIGKLTVIPHHVQMDIGAIYTCHRSADALPILLRVYQKGDCAFCRHYIVKAMHHCGVLPDTILEECLYDSYDETRDFVKRLIKRHSSHSGATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE8</accession>
    <name>D4MAE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum ABC transporter, periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_20850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1344"/>
    <dbReference type="HOGENOM" id="CLU_065520_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1256-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061867" evidence="4">
        <location>
            <begin position="32"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="283" mass="30186" checksum="16DC43274514F0FF" modified="2010-05-18" version="1">MKDWVKQMNFKTLTAVFLLLTSTLAATKASAAESGAKTELIVFAAASMTETMTKIKEFYEAMHPDVNLVYNFDSSGTLKTQIQEGAACDIFISAAPKQMNQLDAAAGKEANPDGLDFVADGTRFNLLENKVTLAVPEGNPKNITSFEQLAKLLTDGNVLLAMGNSDVPVGQYTQKILAHFKLDEAKLASDGKITYGTNVKEVTTQVAEGSVDCGVIYATDAFSAGLTVVDSATPEMCGQVIYPAAIMKNSRHMDAAKDFLKYLTGDAASSVFTGVGFTTIQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF1</accession>
    <name>D4MAF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized MobA-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20880"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1347"/>
    <dbReference type="HOGENOM" id="CLU_699559_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1259-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017587">
        <property type="entry name" value="YqeC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19842">
        <property type="entry name" value="YqeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="180"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="397" mass="43312" checksum="3604182E16A4696B" modified="2010-05-18" version="1">MNVCITTTTHIYNMPDRLNRPGMGDVVYRGIPEGEKLAYPGRAELVRLCREFDAVFVEADGSRHHPIKIPGAHEPVIPQEAGEIVVIMGFHSIGRPIGEVCQHLSLSDVDKMRAEFPGLTAVSPVTTAMIDFIAHTYYLAPLSTSEKFRNVPITYVRNNFLSAPSGMPAQVGKRVALILMTSGFSQRFGGPCSAKALCVPASNGNKLLYPFLGKELFRHGLASLIGAGDSLLKENGIESMIFLTEGNGLEERLSSDERDNVKLVPNPERSEGVAGSIRWGTAAAQATGCDAVLFMAGDQPNFPAADTARLVREFLCSGRPFGCAFSDHPANPGIFARVCYNDLMRLSGDAGAMRLIKKRPWMAYYYVVSPEKLLDVDRPDDLRHLILNGELPPPNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH7</accession>
    <name>D4MAH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_21270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21270"/>
    <dbReference type="HOGENOM" id="CLU_041631_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1286-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="56"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="158"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="35109" checksum="CBA3C6D51926C1DC" modified="2010-05-18" version="1">MSQFEEGVMLGKLPPDELRRNVLRYAGAPRKDLIVGGGLGEDAALIRWPDAERFLVVASDPIVGASEGAGELLVHVNANDVVCKGGEPSWLIVTLIVPAGEGVAMVGRIMREVHEACAAMGIAVVGGHTELSDRYDWPVIVGTMMGPANCRLGISRIRPGDRLLVTGHAGLEGMSILAHDRPDLLGCLSAEELATVRAWRKDLSVVPAARALRDFSHYMHDPTEGGLEGALLEVCKAAGLPLTLDRDAVPISPITRRAAASLGFDPMRLISSGMLIAAVSEEGVGAAQAALLQKRIPSSIIGQFGTTKGDGAEDRLDMHEELWDLLARGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ0</accession>
    <name>D4MAJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="6" type="ORF">SY1_21610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1414"/>
    <dbReference type="HOGENOM" id="CLU_007383_14_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="5"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="363" mass="41492" checksum="3FAECA80F14EBD7A" modified="2010-05-18" version="1">MKTALITGITGQDGAYLASFLLKKGYSVHGIKRRSSIFNTARIDGLYRDLHEEDPHFFLHYGDLTDASNLIRIIQQVQPDEIYNLAAQSHVKVSFETPEYTADSDGIGTLRLLEAIRILGMEKRTRFYQASTSELFGKVQETPQRETTPFYPRSPYAAAKLYAYWITVNYRESYGLFASNGILFNHESELRGETFVTRKITRAAARIALGLQDKTWLGNLDAKRDWGHAEDYVEAMWRILQHDRPDNFVIATGETHSVREFATLAFKEAGMEIEWRGSGLDEVGVDAGTGRVLVEVDPRYFRPTEVDLLLGDPSKAERELGWKRKVSFSDLVRRMVRYDLDLFKKDILIRDAGYEVRSALEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAM4</accession>
    <name>D4MAM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22170"/>
    <dbReference type="HOGENOM" id="CLU_3251946_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1333-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="42" mass="4835" checksum="6608ED222E4B4E74" modified="2010-05-18" version="1">MRECQGFRPKPKKPEPKAEQLRMFDDWGHAAPEAAPADEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN0</accession>
    <name>D4MAN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22250"/>
    <dbReference type="HOGENOM" id="CLU_3270457_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1339-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="41" mass="4791" checksum="B382187730435D32" modified="2010-05-18" version="1">MSMVRALRKAMRRNRQQFGMFFGVSPEMVRELGGVSTWRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN4</accession>
    <name>D4MAN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22300"/>
    <dbReference type="HOGENOM" id="CLU_1692937_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1343-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="155" mass="17011" checksum="9A39FD572D192E32" modified="2010-05-18" version="1">MKISDRVKTLRDLRGLSQGDLAQIIGVDVNTIWRWENGRSSPARSIQKLAQALDTTTAYLLGETDNPKRYTSRLLELVGTDGNESSLVTSEHSTLGDSEAVARLIYERPDGERLELPATPEGYALFEKLVVAMMTDSLKKEFSDSPHSGGAEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ2</accession>
    <name>D4MAQ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_22610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22610"/>
    <dbReference type="HOGENOM" id="CLU_073546_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1363-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="10">
        <location>
            <begin position="57"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="286" mass="31496" checksum="FF3396BF22268169" modified="2010-05-18" version="1">MGRLIVNHWVLGMLTLVTASVMLWILGMTTLFSLNIENLLSRLESELVIQAYVRKGSDVEQVLRKIQALEAVAATKAYSPAESLAKLQEKMGSQSRALDLLGDNPIPWNFEIRVQNASDVEPLVRTLMAMPEVEDVIYAGMVVQRVKALSRVSSRVAFMMFVLSIVITALVVYNTIHISLYSRREEIGIMYLVGATRAYIATPFVLEGTLLSLVGSLIAVGGIVSTYLPGISILQRNLPFLTSGLVADPYVIARFCVLLVGFGATLGWVCSYIVVARFMHAETRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR0</accession>
    <name>D4MAR0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_22710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1515"/>
    <dbReference type="HOGENOM" id="CLU_078758_6_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1371-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="175" mass="19304" checksum="38A1E9D668BEA48F" modified="2010-05-18" version="1">MARGFNKVVLMGNLARDPDVRYTVERRAWARFTVAVGYAWKNKSGEYQDGTDFISVVAWGPLAERCGRYLKKGSGVLVEGRIRSRSYDARDGSGKKYVTEVEAGEVVFVGGKRTSDEGVPYDPQAAPDSSSPSSFSSDEDFGKSIHEKGFSDDFPMDFAEMEKDANKSAESDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU0</accession>
    <name>D4MAU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="2" type="ORF">SY1_23230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23230"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1567"/>
    <dbReference type="HOGENOM" id="CLU_077150_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="324" mass="36480" checksum="0ED986C0F56D73CF" modified="2010-05-18" version="1">MDVLTPAPQQARPQYGVIALPGDLSLPLDLEAMARGRRTELEIGFGNGEYTVKHARRAPDVLLWGIELSPACVLRCARRAAGLDNLRLIRTDARRMMKELFRDEALDRVYMNFPCPWPKRRHAHRRVTARDFTDSLAAVLRLGGVFELLTDDEPYAREALDRIGNHAALEGRGFEVNPARSVTTKYERKWLELGKPIYRLTFVKTRPFTTARQTWEGSEVHIRTRRRPTEACLNALADVSGGAGDARWSFGRLALERGPEGGFLLEAFSNDEEFDQRYYIHISPRDEGALVRLDRTANAFLTPAVKGALADVATRIDAPEEPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW9</accession>
    <name>D4MAW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_23640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23640"/>
    <dbReference type="HOGENOM" id="CLU_780222_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1431-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL29014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="355" mass="38689" checksum="302E135BB6251253" modified="2010-05-18" version="1">MQDHDRTTGSPQADLPPLDPTTERLVSELAARLLPPLTQALARSAAPRDREDAAQEVKAALKDGLDGLSRALQEDLRREAERRQALLQPLAAAVDEIASLRVFFGEATGSIRSAREDAQALARMREALSRLEGAVKEGSEEGRSCRQALIAPLGTILDELSALRGEVRNAGEALRGVSAQGKGAGELHDEAARLRGLLERSEERDLERREELKTTAEAVARAAEGLRRGLEAEREAAREATGDTPGAEALKRLMDVTIPSWEGMLRAHRQAQTRELDALSKELSNLESQTSAAMGQTIQETLRRELAAREEEWSRRLSAERAETAERTRKLIWILLGLAGLSGLSVLCAVAALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY9</accession>
    <name>D4MAY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_24040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24040"/>
    <dbReference type="HOGENOM" id="CLU_2316197_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1451-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="99" mass="10942" checksum="43FE79C6125BF504" modified="2010-05-18" version="1">MTIALYCRLMETAEDLCGQDGVCAAAEGLKRWALVALQTLHLQAEHTLLPMNMDFVRLNFPLALDPDVDGAIWGKHKTGQAMEIMKKLVLYPIAKACKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ1</accession>
    <name>D4MAZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_24070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24070"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1651"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1453-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL29036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="334" mass="37536" checksum="2A544F4D5ED2D388" modified="2010-05-18" version="1">MREDKSEYALEIQDLTVEYRTRGQTVYAVNGLNLKVRHRQTLGFVGETGAGKTTTGLSILNLLPQPAGHITHGNIFLHGKNVLEMSETQLQEMRGKEVSMIFQDPMTSLNPVLRVNLQIAEVIEKHEHISSERAFQRAGDMLELVGIPRERGDEYPHQFSGGMRQRVVIAMALACDPELLIADEPTTALDVTIQAQILELMKKLRDHNNTSMLMITHDLGIVAEICDCVSIVYAGRIVEYGALADIFDHTMHPYTKGLFDSLPDMTNRQAKLKPIRGLMPDPSKLPKGCSFADRCDYAMKQCYTEAPLTFYRTEEHYVSCHLYNAENVLKGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ7</accession>
    <name>D4MAZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_24130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24130"/>
    <dbReference type="HOGENOM" id="CLU_031812_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1459-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="228" mass="24840" checksum="E72CAA8CED58E486" modified="2010-05-18" version="1">MNAAEIAMHAVNIQRESFRDQDTIRVHGVLTKGGTAANIIADDVRLEYSVRGKTIEAYLDAARKVDRSMRGGAIAAGCGLTITTLPGNLPIVPVKDASVVGEALAEVCGDTPVTCTGPEFHSTSSGDYGDVSCLMPLLQFNTGGFRGVFHSPDVFVDDPYEAYVVPAKIFALTAWKLLRNQSERARKIINEFRPTLTMKQYIELMEGTLKTETHSIQPLPLLNETNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB02</accession>
    <name>D4MB02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type Fe3+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_24180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24180"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1660"/>
    <dbReference type="HOGENOM" id="CLU_021838_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1464-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="244"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="524"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL29047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="729" mass="79496" checksum="B998FF7350D903D5" modified="2010-05-18" version="1">MRQRRAVHFALMMAFVALVGWWVYDSVLTGFLEVSHDGQRRTVQTVSLGYPGGDEAEGWLARLAGSSQSYRVALTEGLPAPGASFAVRGDPDLAELCRASAASPQFAKGFDNAAYEEIYRSEHGWDLAGTEQTLFFAPAVDARTGDVQGALIFAFSREGERGFIRMLRMLFAVVLLLFTVVVWQVMMSRDPVVGFALAGLFLMALVFVAYPLFEAVRLSFLEEGRFSLGIWRTILTNSSYIDALKGSLKLGCCTATLSTLIGFLFAFTCTRTNVRFKRFIAMMGVLPVISPPFSLTLSIILLLGNNGLITRWLGLTGFSIYGLPGLTMVQTMCMFPIAFLTLSGVLEAIDSTFEEAALNLSASRLKTFASITLPLAAPGLLSAWLLVFTTSLADFANPLLLAGDLKVLSVESYIEVTGMNRLGHGAALSLLLLLPTLAAFLAQRFWVAKRSYVTVTGKPSGRIAELATPGLRRVLACVIYLIILFLILLYGTIVAGCFVKNWGIDYTFSLENIREALTRSRDALFDTVTLSAVATPIAGVIAMIAALLIVRRRFRGKRLLEALLMTPFALPGTLVGISYILAFNRAPLVLVGTAAIIVINYVVRELPVGIEGGVASLRQIDPSIEEAAMDLGADSATVFRTIVLPLVRPAFLSSLSYTFVRSMTAVSAVIFLISARWYHMTILIYNFSENLRFGLASVLSTVLIVIVFGAFGIMRLLVRRNENLLKNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M701</accession>
    <name>D4M701_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase FliI/YscN family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_00670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00670"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.101"/>
    <dbReference type="HOGENOM" id="CLU_022398_5_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-28-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="4">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="3">
        <location>
            <begin position="155"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="325" mass="34315" checksum="C82CAEB08A4F591B" modified="2010-05-18" version="1">MSGADGATAGTDLLAVLEADLRQAQLVKVNGRVVQVVGLVAESQGPDVRVGDLCHICFRNGSSALDAEVVGFREDRVLLMPLGNLQEVGPGCDVVSTNRPLEVPVGPALLGRVLDGLGQPIDDRGPVIAKDFYPLHAMPPHPLKRQMVDRPLSVGVRVIDGMLTLGMGQRIGIFAGSGVGKSTLLGMMARYTTADVNVISLVGERGREVREFIERDLGPEGAARSVLVVATSDQPPLIRLKAAMTATAIAEYFRDAGRNVLLMMDSVTRVARAQREIGLAIGEPPATRGYTPPCSSCCPGSWSAPERGSGGASRGSTPSWWRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M715</accession>
    <name>D4M715_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antitoxin, RelB/DinJ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.360"/>
    <dbReference type="HOGENOM" id="CLU_154558_5_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-42-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="87" mass="9640" checksum="3ECD2A9998301FBD" modified="2010-05-18" version="1">MATIQIRVDDNTKAAADSLFSSLGLDTSTAVRIFLMKALEHNGIPFAVSHRVPTLELMEAIRDTRERRNLHGPFKTAEEAVASMLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M716</accession>
    <name>D4M716_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_00910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00910"/>
    <dbReference type="HOGENOM" id="CLU_054750_5_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-43-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="241" mass="25365" checksum="D6237A3FBD0B5268" modified="2010-05-18" version="1">MDWVVAAAMMGVTVVGGVVASVCGFGFGAVAMATWPYFLPYQQAVAVSALCGLSTALMIAVPHHRSINFKILLPCSLVALCCSAASVQLSLGAAEKFMIHALGAMLIAVCLYFIFLGGTIRIKGTPLNGVIAGAIGGTCAGLFSVGGPPVAIYLLAATDSNEEYRATLNASFCFTSGISTFVRWHNGVITSTTFHLWLLMLAALALGVFLGNKIFYRLDAKRLRFAVYGYMAVSGVTMLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M727</accession>
    <name>D4M727_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein, putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_01060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01060"/>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-54-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="272" mass="30822" checksum="9293EFB14D0C3C8F" modified="2010-05-18" version="1">MEKHELYRMTWKEVENAFKKDPVILIPLGSTEQQGPHTPTGDYRCAEAVAKAVSKRTGAYMTTCIPFGYSEYFRGFPGSVSLQPKTFISLMEDICCCFLDHGIKRIMFFNGHAGNNPLLDRVSRMILRERGIMIPNVNLWSLLTPAFRKSVFDDPKTSAHGAEPLTSMTWYLNPEDMRMELLPERPRINRQVQGMDVENLTTLTYDGIGFSVFMNMEDISPDGIMGNALLASPENGKKLFDEVIRNACKLVEKWKTVNTCWPSGEGHIVEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M741</accession>
    <name>D4M741_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01210"/>
    <dbReference type="HOGENOM" id="CLU_3396663_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-68-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="31" mass="3277" checksum="F66A3B85496B7AB2" modified="2010-05-18" version="1">MPEKDITERQPEGSPKGGTEGLFGLKGSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M747</accession>
    <name>D4M747_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_01390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.616"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-74-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="518" mass="56665" checksum="DDB1664EA4946961" modified="2010-05-18" version="1">MSRMSSPAIGIDLGTRNALVAFLDEDGAVRLIPNRWGTTTTHSVVGWEDGAWVVGEDAVRLGLRGGSVWWDLKRKVGTSFRAFPDGRPRAAQDLLVPLLEALREDAEVCLKSFVSSCVLTVPACFTLPQREAVIRAASAAGLDARIVSEPTAAALAFGRQGRFLVLDFGAGTTDISAVESEGGVWQVLESVGTDTVGGYEFDVALAEWLRESLLLDKFDAGDVRWQLLLQEAERIKIALSDCWSVHWTPLALGGWAPPELTVYREDMERLMRFSIRRLIHTVRRLWDRYGPEHLLLVGGSSRIPLLQEILEREVALPERLSLSAEDAVARGAALYTASGRERLLLDALSGDLNALWCGQTLTLIPSESVLPAHAEVVLEAARTGRATLEIRQSRNELRDESVRLGSLDLEVDAGEELRLACLLSASGRFTASLTRGTGECVPIPLVLEGTQAGRSPEAENDRRLRELKLSLVSLETLLSDSQRARLHLLFRRAEGAPSDPEVMGLLEGLVKDLKRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M756</accession>
    <name>D4M756_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine aldolase</fullName>
            <ecNumber evidence="6">4.1.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_01480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.5" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.665"/>
    <dbReference type="HOGENOM" id="CLU_029381_0_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-83-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="345" mass="37770" checksum="CF1E1F04FB194FA5" modified="2010-05-18" version="1">MIDLRSDTLTLPDEPMLRTILTARLGDDGRLDAEGRGEDLAVNELEDMAAEVSGKEAGLLCASGTMGNQAALLTWCRPGDTVLIDELQHLDRSEKTAFTPRFGQLKKVTYRSDASLMPNTASMEEELKNGPVKLICIENTHNYTGGACIDLKRMAEIRSLADRYGVPVHMDGARVFNAAAFLGTTVKEIARYVDSLMFCVSKGLGAPVGSLLCGTRKFISEAKEMRKLLGGAMRQAGIIAAPAIYALKHNVERLREDNENAQFCASLLKDLKKVKAQQNVQTNIMMLDMEGAGITPQEFCARAKERGLLIRPIIGSFVRLVFYKGITRSDAERAAAIVREIDGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M778</accession>
    <name>D4M778_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretory pathway, component PulF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_01800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01800"/>
    <dbReference type="HOGENOM" id="CLU_035032_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-104-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="282"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="411" mass="44875" checksum="D90CE469B2BE195D" modified="2010-05-18" version="1">MNFKYRVRASDGNIQEGQLEAESQGLALQALREKGLLVLSMNAATAGGREVGSSGAGLSFFEKLQRIGAVPAKAKMVFFRQMATMVQAGLTLSMAIDIIAEQERSMVFKDVLLDVKGRLDRGIPMSQAMRAHPSVFNNMMISLVQAGEEGGLLDNSLERVAGLLEKQAALKSKIRSAMFYPSFVIFFAVAVVVVFIAFILPKFQQVFRGMNIELPALTEMLFSLGEYCTENWLSIVIWTLAVVGVLGFLLRSKATKPMMDRVKLKLPVIKSLVFKSGMARATQTLAALVTAGVPILRGLEMAENAAGNEVIRQGFADLQASAKQGVHLGDAAKRAKVFPILVCQMMRIGEETGHLDDMLERVARWYDQELDEQIKAMTSLMEPIMIMFVGGLVAVIALAIFGPITAAMSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>D4M784</accession>
    <name>D4M784_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">SY1_01910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01910"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1032"/>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_0"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="9"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="354"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="419" mass="45638" checksum="FA5E35CD1FF5AF3A" modified="2010-05-18" version="1">MDKDADRYLRDVDPEIADVIVEEYRRQNDQIELIASENFTSRAVMAAMGSVLTNKYAEGYPAHRYYGGCEVVDKAEDLARDRAKKLFGGDHVNVQPHAGSQANMAAYFACLEPGDTILAMNLTDGGHLTHGSPVNFSGKLYNVVPYGVRKDTETIDFDQVRELAKKHHPKLIVCGASAYPRIIDASKFREIADETGALVMFDIAHIAGLVAAGAHPNPVPYCDFVTTTTHKTLRGPRGGMVLCKECFAKKVDSAIFPGMQGGPLMHVIAAKAVAFAEALKPDFKDYQHRIVANCKRLAEKVMERGFRLVSGGTDNHLILVDLTSKGVTGKDVQIALDRAGITVNKNTIPFETLSPFVTSGVRIGTAAVTTRGFGAEEMDRIAGWIDRVVTHIADEAEIGKVRAEISELCAAKPLYPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A8</accession>
    <name>D4M7A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, NhaC family (TC 2.A.35)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_02270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02270"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1638"/>
    <dbReference type="HOGENOM" id="CLU_551812_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-136-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="11"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="491" mass="51738" checksum="A23557142FF5794F" modified="2010-05-18" version="1">MIALLKLSPIAVLAGMMIGGIDILLSAPVAFVCAVLVAMATEHYSFGELQDAALDNLRHFLIVFLILQAAYAVAECFMSTGVAAAIINMALSMGMTAKLVAPACLVVTAILSVATGTSWGTFAACAPIFLWLNHIVGGSTVLVIAAAVGGSCFGDNIGLISDTTVVSSGMQNVSVIDRVRHQGVWSGLCLLLGVAAFYFASVSMGLSDVAGSAEEAIRQIPDTVWAALEEKRPAAVTLLHQVQAGVPYYMVIPLVLVLILAARGTSTLICLAAGILSSLVFGFAAGTVTSLAAFGERVYAGFSDAGGWSIAMMLWVGAFGGVMRKMNAFDPIAAAVLKCVSRVRQLMFANAALCLLGNAALADEMAQIVTLSPIIRNLTEQNVEGDPKALYRLALRNATFADAMAVLGAELIPWHAYMAFFAGIAWAVYPLAAGTVSLGDIILHNYFAWIAVGSMLILTWTGWDRFVPLFALPTEPEVRLRRAADPEPKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C8</accession>
    <name>D4M7C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1710"/>
    <dbReference type="HOGENOM" id="CLU_029601_0_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-158-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="363" mass="38866" checksum="50AB2FF9655023BF" modified="2010-05-18" version="1">MDSTLKAALLMNAAHAPLPAFRKLCENYAPEDLKREELWDALNLTPSVRKNLSRLLREGDWPEREEERAARFGARFLTVDDPDCPARLQDLSQPPIGLYVKGKLDVALPSAAVVGTRRCSAYGKTVAEALGRALARGGLMVVSGGARGIDAAGHRGCLAEGGVTVAVLGTGIDRVYPMEHRELFAQIAETGALVSEYPMGTDGAAWHFPERNRLIVGMTGRTVVVESPEDGGAMISARLALDLGREVWCVPGRITEGVCRGTNRLLRDGAEPLVDVDEFIHCATGRYGQLVLDLDEPAARPQPPLSTDEKVVLALLQRQGGRTMDELLAESGLDLVTLQTCMMTLSASGLAVVSGPGRFSAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D6</accession>
    <name>D4M7D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 2, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_02640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02640"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1741"/>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-166-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="299" mass="32014" checksum="5438AF72789CADA8" modified="2010-05-18" version="1">MVEGYASGVVTLLAINLIAALGVSLFTGFTGIFTLGHAGYMAIGAYTAAILTVEYEVHFAAAILAGGVLSMVLAYLIGLPTLKLVGDYYAIVSLGLGEAIRLIIENWNSVTRGARGYPGIDNYTSMTVAVSFFLVLCVLMFFLINSRYGRAFKACRDDYVAASLLGFNTAHFRVLSLAISAFYCGVAGALLAGYMSFIQPVMFDQVKSTELVSIVVFGGLGSTSGCLIGTTILTLVTELFRPISQYRMLVYGAVLVLIMVLRPEGIMGTNELTPAYARRVLKRWRKSPAAGPDEKGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E4</accession>
    <name>D4M7E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_02770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02770"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1756"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-174-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="328" mass="36320" checksum="BED04CC11B8C1946" modified="2010-05-18" version="1">MDDRLLLQVKGLRTWFHTFKGVVKAVDDVSFDIRVGEVLAVVGESGGGKSVTGFSVIRLIDEPGRIESGEVLFAGRDLMKLSEREMNRVRGKDISMVFQDAMTSLNPVYTIGQQIDEVLRLHTSMGRADRRRASVELLRSVGISNPEGRLGSYPHQFSGGMRQRVVIAIALAARPRLIIADEPTTALDVTVQAQILRLMTDLIHAEGCSLMLITHDLAVVSEIADRINVMYCGRIVESGPARAVIDGSLHPYTLGLIDSIPDLNREQGRFKTIPGIVPNMFDLPRGCRFSPRCERAQDLCRTSAPDLRELEPGHCVACHFPIHREVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F0</accession>
    <name>D4M7F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AHS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_02840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02840"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1763"/>
    <dbReference type="HOGENOM" id="CLU_020207_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-180-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="243" mass="26792" checksum="EB2C9F25A5AF984A" modified="2010-05-18" version="1">MDAKILPAGETCLFVDFGEKIDMEINRHVQAIKRALLDRPFKGMKELVPTYRSLSVYFDPLTVDLPALKKRLEQELEGAGPADSASTTEVCVPVFFGGEFGPDLGEVAAHTGLSEDEVVRRYSESPLYCFMNGFTPGFPYLGGMDPSLETPRLKTPRELIPANSVAIGGAQAGAYSIASPGGWRIIGRVPYDLYDAGREPAVAIQAGMWVHFYPVTMERYREIEAEAKSGTYRIEYREKGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H5</accession>
    <name>D4M7H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">[citrate (Pro-3S)-lyase] ligase</fullName>
            <ecNumber evidence="2">6.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03230"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1802"/>
    <dbReference type="HOGENOM" id="CLU_063190_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-205-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008771">
        <property type="term" value="F:[citrate (pro-3S)-lyase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005216">
        <property type="entry name" value="Citrate_lyase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013166">
        <property type="entry name" value="Citrate_lyase_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40599">
        <property type="entry name" value="PTHR40599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08218">
        <property type="entry name" value="Citrate_ly_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00764">
        <property type="entry name" value="Citrate_ly_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00124">
        <property type="entry name" value="cit_ly_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="36012" checksum="70455745DF336001" modified="2010-05-18" version="1">MGEVSVDTIYRPERDAALAALLKANDLTLPEGADEGVGLYEDGHLVGCGFLKGNLLQGVAVDAAHRGEGLSATLITALIQRAVQRGITYWQVITKPDMERFFAGLGFRRVADARPYAVLLEAGSGSASAYSEGLRRQAEGRPTPRACVVMNANPFTLGHRRLVERAASENPWVWVLAVREDRSEFPFDVRFRLMREGTADLTNVEVLSGGEYVISARTFPAYFTRQESLASAQGTLDAAVFCDLVAPALGVARRYVGTEPFSPSTARYNEALLEQLPKRGIQVVVVERASVNGEAVSASRVRAALAAGDWDTVRAMTPDSTYRYLQERRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H8</accession>
    <name>D4M7H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative virion core protein (Lumpy skin disease virus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_03280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1807"/>
    <dbReference type="HOGENOM" id="CLU_037108_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-208-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Band_7_1" evidence="6">
        <location>
            <begin position="43"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="339"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="389" mass="42703" checksum="793A9F542C7859B3" modified="2010-05-18" version="1">MAMFGRNPNEAAYVGGRKHFTDVIKNTGPGNLLIWLNGEEDFNTNSTLIVAESEEALFFRDGIVEEVFDGGKYVLSTENYPFISRLRNLFSGGISTFNCKVYFVRKAHSMEILWGTDSPIQVRDPVLRIATSVTARGAFKVQVDNSKLFLIKLLGNNVQQLTQEELTRYFRREFMQHIKSNIARAIRESNEEILGICERQALLAEHLTPILREPLADYGVRLVNFTIEAIDIPEQDPNRQKLEAAYANKGVMGILGNDWGRQQATEILHDVANNPGAGGVAATGAGLGMGMVAGGVFNSMAQQMFAPMQEPRPEERPFPQGPSGGRFVQRDGPGGAKRCAHCGADNPEDSLFCGRCGTRLDAPEATCGNCGAVLPPESRFCNKCGTPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H9</accession>
    <name>D4M7H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03290"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1808"/>
    <dbReference type="HOGENOM" id="CLU_1228441_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-209-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="225" mass="25280" checksum="2EA5BE3402E6F0B8" modified="2010-05-18" version="1">MKNGILWLILKALFPVLFNAVFFLADIQPKNASVWISYVFVHSAYVLLLLTPRFTVRSRSAALFGTTLGGLGLFFFLAELALGSVLIAVRPEGWRTAFFLQLVLSVFHIAALTSTMLADQHTAGGETVREAELRTFKGLLYEMRRAVDEAGEGEEARLLRRTYDLMASSPVRSHPSVLDIERDLEAAIRALPRVGASGENREDIARRAEEIQRLIRERNHLLKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J2</accession>
    <name>D4M7J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Copper-(Or silver)-translocating P-type ATPase</fullName>
            <ecNumber evidence="12">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SY1_03580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.4" evidence="12"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1840"/>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-222-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="782"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL27837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="851" mass="89535" checksum="844A85BB1D6A5367" modified="2010-05-18" version="1">MKRESYDVTGMSCAACSARVEKSVAALPGVEEVAVNLLKNGMTVRYDEGVLSSADVVAAVVKAGYGASLRGGAGERREARGPAQDVALQEYLGLRTRLVASLVFALPLSYLSMGRMMGWPMPSCFLGVENALVFALTLLLLALPVAFINFKFFRVGFGALAHGSPNMDSLIALGSSAALVYGVYAIYRMAWAAGRGDAATVSRFSMDLYIESAGMILTLITLGKFFEARAKRRTSDAITRLMDLAPRTAVVERDGAEVEIPIEELERGEIAVVKSGQAIPADGVLTEGAAAVDESAITGESIPVDKVPGDRLVGATTVRGGWLKMRVTGVGEETTLAQIVRLVDEATSSKAPIAKMADRVSGVFVPIVIAIALATGAIWLLAGRGVEFALSMAISVLVISCPCALGLATPTAVMVGTGRGAASGILIKSAEALERLHDIDTVVLDKTGTITQGTPVVTDVLCPAMDQREFLRAAASLESRSEHPLAAAVTARAEAEGLELLSVEDFAQEAGAGVRGVVGGREWRAGNRRVLEAAGLYDERAKELEQKLADEGSTPMFFVTEGRLAGVIAAADVVKPTSRQAVGELRRMGLRVAMLTGDNRRTACAIQRQVGLDEVTAEVLPQDKEGEVRRLQEAGRKVAMVGDGINDAPALARADVGIAIGAGTDVAIESADLVLMRSSLMDVAGAIQLGHAVIRNIKQNLFWALFYNALCIPVAAGVLYPLWEVKLSPMLGALAMSFSSVFVVSNALRLRRFRPSYASADPIVEASGAAEGDEGKGVMKVKKLLHVEGMMCQNCVKHVRTALSQVSGVSGVEVSLEDRTALVTLSGDVADAVLTKAVTDAGYEVKSVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J3</accession>
    <name>D4M7J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, NhaC family (TC 2.A.35)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_03590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03590"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1841"/>
    <dbReference type="HOGENOM" id="CLU_033405_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-223-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004770">
        <property type="entry name" value="Na/H_antiport_NhaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00931">
        <property type="entry name" value="antiport_nhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="192"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="504" mass="53745" checksum="C6577C381A972881" modified="2010-05-18" version="1">MDKNIDAAGNFDNLQTVEEEFLGEPGGGKKEPGSRTPRKANLIEALFTFGFLIVVMSVSIIKFKLDPHIPMFVGVIAAAVMGLWLGYKWESLENAMIKGISQAMQSIIILAIIGMLIGVWIVSGVVPSMILYGLKLLSPQLFLPAAVLICSITSLATGTSWGTAGTMGVALMGIAVGLEIPLPLAAGAVISGAYFGDKMSPLSDTTNLAPAMAGTDVFTHVKAMIPTTVVAYLAALGLFAYMGMGYGGTETSLESIKLIQDGILSQFKVSPVLLIPPALVIVLVAMKMPAIPGIVIGLLTAAFLAPIYQGASLGDILKCAHYGYVSETGVEVIDTLFTKGGLEGMLFSISLTIIAMMFGGIMEETGQLETIVNAVLFRLKSYAGLIVSTEVTCLFSNITMPEQYISIVIPGRMYAQSYRERGLHPSQLSSTLEGMGTVSGALIPWNTCGAFMSNALGVPTALYFKYCFFNLFMPLVVAVFAFLKFNVRYMTEEEKAQLAETGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K2</accession>
    <name>D4M7K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1858"/>
    <dbReference type="HOGENOM" id="CLU_028871_10_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-232-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061825" evidence="1">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="369" mass="40727" checksum="9DC4F8ACFCEE00BF" modified="2010-05-18" version="1">MKKFVAVLALSWAFALPAFAAEAEKVPVIRMAYTMTTHQQGFTIALQKGEAFKDFGVWFKPVVEKEKYDLYRGDKKMARFEVIVTKSGSEAASLFAQNHLDLTTNSFPAMLSAIDNGTPIKVLAPIQADGIAMVGRLDSPVNDWDSLLAFIKEAKAPVKLGYHSPTSAPKVLVEAALFEAGLRLTGDANATKQEADVLLVDLKGVANFNPALTSGQVDFWVAPAPIPQVAVLKKQGKMILDLKTLPPAGKWDHFPCCVTAAHVNVIEQHPDILDAYLELLTKSSAWCNAHKDEADELSAVWFGVPVEATRMSEMTYSTNPDAKWFRNASLYPEMLNKMGQFKNLLKGKTLEESKELVFDFRYAEKQNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L7</accession>
    <name>D4M7L7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplA</name>
        <name evidence="10" type="ORF">SY1_04010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04010"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1882"/>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="234" mass="25261" checksum="202A866F13035DAB" modified="2010-05-18" version="1">MKHSKRYRAAAEKVELGKLYGLREAVELYKQIATAKFNESLEVHVRLGVDPRHADQQVRSTVGLPHGTGVTRRVLVLAAGEKQKEAQDAGADIVGGEDLVQKISGGWLEFDAVIATPDMMKSVGRLGKVLGPRGMMPSAKTGTVTFDLTNAISEIKAGRVEFRVDKAGITHNAIGRREFTVDQLFENAKAILQAIYKARPASVKGTYVKSVTIAPTMGPGIAVDPLDVQREVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L9</accession>
    <name>D4M7L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">SY1_04030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04030"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1884"/>
    <dbReference type="HOGENOM" id="CLU_086499_3_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="127" mass="13331" checksum="BCBAA76D8623F84E" modified="2010-05-18" version="1">MTHEELIKAIEEMSVLELSELVKALEEKFGVSASAAPVAMMAMPGAAAGAGAAAGEEKTEFDVVYKGPGSNKIAVIKVVREITGLGLKEAKELVDNPPKPIKEGVSKEEAEELKKKLAEAGADVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N5</accession>
    <name>D4M7N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_04290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04290"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1916"/>
    <dbReference type="HOGENOM" id="CLU_028880_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-266-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030158">
        <property type="entry name" value="MglC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32196:SF18">
        <property type="entry name" value="PTHR32196:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="424" mass="44962" checksum="B1D4E75D56135B2C" modified="2010-05-18" version="1">MAERRITREKYNHFLRTSGASVLILGVILKAVQAVPALSGIKEALSLKSVYDLPVFLMIIGAVVALKGVVAARGRGAEGEAEDVVLSRKSFGAFLTNYAILLAMLVLVVVICVIQPRFMQVRVALDVLTQSSTRLIIALGICFTLLIAGTDLSAGRMVGLAAVVSTSMLQTSAYANRFFPDLPQVSVWLPILLAVLACMAFGALNGFLVAKYDMHPFIATLATQVIIYGACSLYFDMPPNNSQPIGGIRPDFTALGQMKVFASSEPGGFPGISILIPIAAVICVLIWFILNKTVFGKNVYAIGGNREAAVVAGISVFRNIMGIFILASCLYGIAGVLEAARTAGATNNYGNGYELDAIAACVVGGVSLNGGIGRVSGIVSGVLIFTIIQYGLQFVNVSPMWQQVIKGVIIAAAVAIDMTKYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P8</accession>
    <name>D4M7P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_04510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04510"/>
    <dbReference type="HOGENOM" id="CLU_1756152_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-279-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="148" mass="16571" checksum="6D0DEE8025FB0D6B" modified="2010-05-18" version="1">MQNTQDELEREDEETIVGEATEDTNEATHDDAEARHWLKVFAALAFWGLGFLLFYNGGPGVFKSFVSPMDFENHYLFYGAAAFVAMVVCGANTLACIVIGHRKNANLFMLFIAVSFISIFVVLSLFGAVFSFFAGQATTPYRRQDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q1</accession>
    <name>D4M7Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_04540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04540"/>
    <dbReference type="HOGENOM" id="CLU_2769890_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-282-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="69" mass="7988" checksum="D91453C36334F027" modified="2010-05-18" version="1">MVFSEKEHHFMNGCLNALIVRLPFNEVQCVEDLKNVLISLMKIDIPIKYFMIDQEVEDITGLYIANETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R0</accession>
    <name>D4M7R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formimidoyltetrahydrofolate cyclodeaminase</fullName>
            <ecNumber evidence="2">2.1.2.5</ecNumber>
            <ecNumber evidence="2">4.3.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.5" evidence="2"/>
    <dbReference type="EC" id="4.3.1.4" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04790"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1972"/>
    <dbReference type="HOGENOM" id="CLU_088419_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-291-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030412">
        <property type="term" value="F:formimidoyltetrahydrofolate cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="209" mass="21991" checksum="C980F4B79A6EC627" modified="2010-05-18" version="1">MKLTDLSLKDFTAKLGSDAPAPGGGSAAALSGALGAALVSMVCNLTKGREKYAEFETLVVNTLKESDELAAALLEGVQKDTNAFDGVIAAYGMPKGTDAEKAARSEAIQSAYKVAILSPEETADNCLAVMRLSRDLLHKSNKNAASDLAVSALQAYAGLIGALENVAINLAAIKDQNYVNDKRKWMDLASDEGEKLLKEVREGVRAMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S2</accession>
    <name>D4M7S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type DNA-binding domain-containing proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04980"/>
    <dbReference type="HOGENOM" id="CLU_052345_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-304-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="232"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="340" mass="37110" checksum="F881C7E921FBF3B1" modified="2010-05-18" version="1">MIERSCSVTFRDHIEFFEAIHETGRPVKAPKADDPEGGLVCLSAPFAEILLETHSLFHGVSLNVLNISPRADIVIPYDFGGGVLGMDYLADGSYLLDESSGRMVSPGDLFLLPPSGCRGSMTFRGGRPSRTIAFGGPGKILSDLLGEDGGALWAEALRAGSGYGSEPRLLRAPQAMAGSFLQMLHYDYPTRVKRLFLEGKLMEILSRIIARGLPSEENEGNGGDAFELERIRMIPGILMERIDNPPSISELAHELSVNSTTMKKGFKNIFGEPIYAHHRNLCLSQAATLLLETDKSVFEIASDVGYSNSGNFGSAFKRRYGVSPIRYRQNGRSALPLQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S5</accession>
    <name>D4M7S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05010"/>
    <dbReference type="HOGENOM" id="CLU_2140606_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-307-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="129" mass="14405" checksum="72E2EF7AF1015A33" modified="2010-05-18" version="1">MTPTRCDPQAPRPEEVLRDRLLLYVRALRLPPREGLELVLKTMDELCPSGTSETLPAHAEDCDMKTAMEALRALCADRGLLPDADALPVPVPPYNRGSMPPARISMTRGGFSLRGLIRRLRRSEEGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V5</accession>
    <name>D4M7V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05420"/>
    <dbReference type="HOGENOM" id="CLU_3396665_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-337-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="31" mass="3438" checksum="7AF5665C5B15AF0B" modified="2010-05-18" version="1">MIYLIAGKLQIGLSLKIARSYKMKEAPWGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W7</accession>
    <name>D4M7W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lactate dehydrogenase and related dehydrogenases</fullName>
            <ecNumber evidence="6">1.1.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_05600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.29" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05600"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2053"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-349-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:glycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="112"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="324" mass="35143" checksum="8318BBA536E3FBBB" modified="2010-05-18" version="1">MSPEIVVLDGYTENPGDLSWGELEKLGALKVYDRTSLTDEDEAIARIGGAEIVLTNKTPITKRVIDACPNVKFIAMLATGYNVVDAAYAKERGIPLSNVPAYGTASVSQFSIALLLELCHRIGLHDQTVHEGRWERCADFCYWETPQIELDGKTIGIIGFGRIGQREGAIARAMGMNVLAYDLYPNDSGRQIAEYVDLDALLARSDAITLHCNLTSENAGLICKNTIAKMKDGVLIVNNARGQLVNERDLADALNSGKVGGAALDVVSSEPIRGDNPLLSAKNCVITPHISWASLESRRRIMECTLSNVKAYLEGRPVNVVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z6</accession>
    <name>D4M7Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAP transporter solute receptor, TAXI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06110"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2098"/>
    <dbReference type="HOGENOM" id="CLU_033215_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-378-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061172" evidence="1">
        <location>
            <begin position="20"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="334" mass="35965" checksum="D9377F68530B585D" modified="2010-05-18" version="1">MKKILALSLILAFAAAASAELTQPVNLTFAAQEVGTGAYSVAAAIQSVLVKGLPQGSTIDLTTNSPGGVGAPMLIQNEDCDLIVSNAGPSLWSYERTPDQYQFGGCKDVRSIGGGLGHTFTNVMFTKKFVDETGITTLEELIAKKHPVKIVTKKNGSLGELTAERVIEACGISVEEFNSFAKWEKTGTDAIKSGLQDDLYEMTIDHIDAGQATTTEIALTHDMFFVQLSDATLANMQKMGYAPIVMPAGTWNKQDKDIKTMGSQQNVLVPAAMDEELAYALTKAICENKDEMAKFVASLGWFDLKTAARKELNGAPLHPGAIRYYKEIGVQVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M826</accession>
    <name>D4M826_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_06530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2142"/>
    <dbReference type="HOGENOM" id="CLU_1056706_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-408-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="131"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="263" mass="28972" checksum="BD57F90E06ED4523" modified="2010-05-18" version="1">MNAFLEFIKDLLTLRTTWIDKGQGRWVARRRMHPLMRLIVFCGAAAAVTVLGVELLRSGPVPAPEAEVPLSGPLDSPDVPALLADEALDAASSEPGAVLPEVEEPEDETPQMTEPTPTPSALRPPRDAGKYWILINKGQYRLSLYRGRDLVKTYNVAIGKNPGNKRRVGDNRTPEGQFRVLSIENASGWKHDFGDGKGEIAGAYGPWFIRLDTGGWKGIGIHGTHAPDSLGTMASEGCIRMNNDEIRDLKNYAYRNMIVRIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M835</accession>
    <name>D4M835_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transketolase, N-terminal subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06660"/>
    <dbReference type="HOGENOM" id="CLU_1675350_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-417-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="157" mass="16468" checksum="0337F76F7598AF10" modified="2010-05-18" version="1">MSLPKLNGFPVPSLSEEDRAALEAAARRARVSALTMVTAASSGHPGGAFSGIEMFLTVYGTANLTPENCNALDRDYVVVSHGHTSAGVYAALAEWGFFDAGEAMAHFRQCGSVFQGHVEREVPAWTGGRATWGRGSPPAWASPWRSAPAGTRGASTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M848</accession>
    <name>D4M848_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol:disulfide interchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06840"/>
    <dbReference type="HOGENOM" id="CLU_053225_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-431-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="238" mass="24626" checksum="D6A8019BACE18B5A" modified="2010-05-18" version="1">MLDAIFSAMLSSGALQWLGAFLWGMASVILSPCGIAAIPLVVGYIANAEEPGRWEAFRISCVFCVGIVLNLLLVALITSGVGVLLGGHERLLTFVTAAVFILMGLHLIGIVHIRLFSFNGGADKAGGTDRRGLRGALTLGVVSGLAIGPCSIGYISPLLSVALSQASTKPVAAAGLIVAYALGYSAVLVLSGTFAQLASRWLQSERGTVILRALNVTCGLALIAAGLYLSREMLLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M854</accession>
    <name>D4M854_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06920"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2182"/>
    <dbReference type="HOGENOM" id="CLU_064691_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-437-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039065">
        <property type="entry name" value="AcoX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011386">
        <property type="entry name" value="Put_ATP-NAD_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697">
        <property type="entry name" value="PTHR40697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016907">
        <property type="entry name" value="Kin_ATP-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="373" mass="39650" checksum="AF9F8F3FDED6E797" modified="2010-05-18" version="1">MKRLGLIVNPIAGIGGKVGLKGSDGVDTLQRALLLGGEFESGKKASVALTQLGTLNKGFELYTCSGAMGAEACQRVGLPCTVVGEPCVTHTGPEDTMRAARALQRLDLDLLLFAGGDGTARDILKAVGQEVTVLGIPTGCKIHSGVYALTPQAAGLLARQCVQGRIHRAKEAEVMDIDEDLFRHGVVQARLYGYLKIPDDEALVQRTKIGGSGSSSVEALARFVAGQWQNDTLYIVGTGSTTAAVMRELGLPNTLLGVDLVYDKRVVALDCTEKRILEAVQEYDRVKIIVTIIGGQGCLFGRGNQQISAEVLRRVGRNNIIVAAGRDKVLSLKGRPLYVDTGDEEVDRSLAGYMKVVIGCEEFTVLKVAGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M858</accession>
    <name>D4M858_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_07010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAE transporter (TC 2.A.81) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07010"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2188"/>
    <dbReference type="HOGENOM" id="CLU_035023_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-441-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006512">
        <property type="entry name" value="YidE_YbjL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06826">
        <property type="entry name" value="Asp-Al_Ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01625">
        <property type="entry name" value="YidE_YbjL_dupl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Asp-Al_Ex" evidence="7">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Asp-Al_Ex" evidence="7">
        <location>
            <begin position="245"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="417" mass="44144" checksum="5C10DDF00617754E" modified="2010-05-18" version="1">MAYFQEIVFSSCRSMMFIIFCITFIGYLLGDIKVKGVELGTAGVFLSALFFGHFAYSDASLLRQMGIITVSSGFMQHSMSLIQEMGLLCFVTSVGFIAGPNFFHNLKKNVKSYAFLGLIIIGSGALTCAAVILLTSVDSAMGVGILSGALTTTPGFAAAQDIVRSNEFLLNEVTVGHAIGYPFGVVGVVLFVQIVPKLVKANILEEQKKINAASGQPLEFTPDRRQEGNAQKNLLDIDPIGLGPLSLAVVLGILLGKVRLPLPLGTHFSLGNTGGALIVGLILGHFGRIGRINMRISAGFLKAFREFGLVMFLIGAGVPGGSGFVDIVREYGLILFLYGALMTTVPLLVGYFIAKHVVKLCLLNNLGAITGGMTSTPALGALINVAKTDDVAASYAATYPVALVLVVLASQFLMTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M864</accession>
    <name>D4M864_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07160"/>
    <dbReference type="HOGENOM" id="CLU_1710615_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-447-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="153" mass="17084" checksum="E34FCF5958A6BAF1" modified="2010-05-18" version="1">MIRVSYDGLFDFVQGFLSARFRLYGLALAAGDNALLTLLMSSGDVSREPELARSLSALMEPLGMLTSVVWFSRGTPGSDWMETRFSLIRSPWAWMALASSVALIVIAGWVGFFWTAFWGTAAWFVVRGLTFLFFRRKNFLLPQAGIRNGDGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M875</accession>
    <name>D4M875_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal/vacuolar-type H+-ATPase subunit E</fullName>
            <ecNumber evidence="4">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_07360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07360"/>
    <dbReference type="HOGENOM" id="CLU_105846_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-458-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="192" mass="21408" checksum="CE9E0CDD5A3A4F3E" modified="2010-05-18" version="1">MSLADIKAKISTESQAEIQAIESEADEKVRQINQELNAEVKSVKDTYASRFAKEEPEVLRRREIVAGIDANKLDLGVRRRLVDDAFAASLRKLADLPADACLKFASRLLKEAVSSGHEAVVVGKDEKHLNQGWLDGYNAEHGTSLTLSQERLPISGGFVLRDEKIDTNCSWEMLLEDVRPEIESEVVKKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M898</accession>
    <name>D4M898_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_07710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2262"/>
    <dbReference type="HOGENOM" id="CLU_037408_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-483-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="473" mass="51475" checksum="378BF71F3E51AB07" modified="2010-05-18" version="1">MDHTRTIPAEESASTAQHPNYEEKIAQVVRGNLTPKIMREQLLTYHENDVAAALDLLKKEDRYRLYSVLNPETLADVLEYSEKINEYVGELNLRKRAEVLAHLEPSVAVDYLQEVEKGERAAIIDLMPDDAKQEISLLSSFDEDEIGSRMTTNFVMIHMGISVRQAMRELVEQAADNDNISTIYVADDDGIFAGAIDLKSLIIAREGTELDSIIMTSYPYVYANELIEDCIERIKDYSEDSIPVLDQENRLKGVLTAQDVAELIDDEMGEDYARLAGLTAEEDLQEPLSMSIVKRLPWLLVLLGLGLVVSSVVGLFEAVAAGLTIIVAFQSLILDMAGNVGTQSLAVTIRVLMDDQCTGRQKLYLVAKEAKIGLCNGLILGSLSILFIGLYLLLVKGEAAHFAFSISLCAGAALALSMSLSSISGTTIPILFKGLGVDPAVASGPLITTVNDLIAVVTYYGLAEGLLRGVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A8</accession>
    <name>D4M8A8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxylamine reductase</fullName>
            <ecNumber evidence="6">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hybrid-cluster protein</fullName>
            <shortName evidence="6">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hcp</name>
        <name evidence="7" type="ORF">SY1_07850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="6">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2277"/>
    <dbReference type="HOGENOM" id="CLU_038344_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="6">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="6">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="546" mass="59339" checksum="420292C7C4168190" modified="2010-05-18" version="1">MKMDCSMFCFQCQETAGGKGCTKSGVCGKKPDVAAMQDLLIYVTKGLSCVTERLRSEGQEVDKKVNHSVTVNLFTTITNANFDRDAIVSRIEETLRLKEELLARVKDASGLPEAASWKGTRDEFEAKAAKVGVLATSDEDIRSLRELVTYGLKGLAAYSKHANALLQDDEAVDAFIQRALASTLNDALTVDDLVALTLETGKYGVEGMALLDRANTGAYGNPEITKVEIGVRKNPGILISGHDLRDLEMLLEQTAGTGVDVYTHSEMLPAHYYPAFKKYPHFAGNYGNAWWKQKEEFASFHGPILMTTNCVVPPAESYKDRLWTTGAAGFPGCRHIDGAYGEVKDFSAIIAQAKTCPAPEEIERGSIVGGFAHEQVFALADKVVDAVKSGAIRKFVVMAGCDGRMKSREYYTEFADKLPKDVVILTAGCAKYRYNKLDLGDIGGIPRVLDAGQCNDSYSLALIALKLKEVFGLKDVNELPLAFNIAWYEQKAVIVLLALLYLGVKNIHLGPTLPAFLSPNVAGVLVKNFGIAGIGTVDEDLKLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B7</accession>
    <name>D4M8B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_07940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07940"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2287"/>
    <dbReference type="HOGENOM" id="CLU_039483_8_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-505-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="369" mass="40047" checksum="0FF09F10034E7543" modified="2010-05-18" version="1">MFARIRSLIVKELYAVLLDPKTRFQVFVGPFVMLFLFSFAITMEVRNASLAVLNQDDGDLGRRLEAAFTAGPAFTRSFALSSVREIEPAIAEQRALMVLRIPEGFSASLMRGEPTSVQVVLDGRKANAVQIAYGYATSIANGFARGLRKTLTGTDALLSVEPRQLFNPNHDYLWFTLPVLLVVLTQMLSLVVSGMSVARERELGTFEQLLVSPLSPLEIVVGKTLPAVAIAFGIGVAIHVLARTVFGVPCLGSLGLLAFGFLIFILACTGVGLFVSSLCNTQQQAFLGVFTCMVPFVLLSGFATPIENMPHALQTLTLFNPSRHIIVIALGVYLKGIPLREVAVQLLWLGGIATVTLGAAGWFFKRRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8F7</accession>
    <name>D4M8F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">SY1_08620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.59"/>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="76" mass="8605" checksum="DA8AE361DA6ED1EE" modified="2010-05-18" version="1">MANAGGKEEVIEAKGVISEPLPNAMFRVELENGHKLLAHVSGKMRMHFIRILPGDRVLVEVSPYDLSRGRIIYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H4</accession>
    <name>D4M8H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplB</name>
        <name evidence="7" type="ORF">SY1_08830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08830"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.81"/>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="275" mass="30675" checksum="2C04E706FD49C3DB" modified="2010-05-18" version="1">MSIKQFKPYTPGRRQMTIQGREDITADKPERSLTRELRKHGGRNNTGRITMRHIGGGHRRAYRIIDFRRDKIGVPGKVATIEYDPNRNARIALIHYLDGEKRYILLPKGLKVGDTILAGPEADITPGNALKLKDIPVGAVVHNLELQPGHGAKLVRSAGTSAQLMAKEGKYAYLRMPSGELRLFLLECMATVGQVGNEEYENISLGKAGKTRWSGRRSSVRGMVMNPVDHPLGGGEGKSKSNKHPVSPWGTPAKGYRTRRHKASDRLIVRRRYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J7</accession>
    <name>D4M8J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09250"/>
    <dbReference type="HOGENOM" id="CLU_1967331_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-590-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="127" mass="14649" checksum="A1D22F3C4E2F45D2" modified="2010-05-18" version="1">MTFVWLGAGIVFFGLGLWQWARGGSGLWQILNLRRREKTLTAEERLEAEGTVHRLERATDRALLLSFRILGYLAIVLWLVLGVSLLMDFLGVDWTSRFRARQYWNADTEALPDRNTVLRSIGSKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M8</accession>
    <name>D4M8M8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_09810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.181"/>
    <dbReference type="HOGENOM" id="CLU_045498_2_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-622-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="259" mass="27233" checksum="EB407A695C782674" modified="2010-05-18" version="1">MGPNLYQALPFWQQAAIVCPLIFLGGFVDAITGGGGLITLPAYLFAGLPVHFALGTNKLSSCIGTALTTARYARAGFIPWKLACLCVAASLMGSNLGAHLALFLNDRIFKFVMLFLLPVTALYVLKGRALVHQRPPLPQARTVLTSAAIAFALGAYDGFYGPGAGTFMLLLLAAAAHLSLNTANGVAKSINMASNLAALTVFLINGRVLFPLGLLAACFGLAGNYLGARSFEHGGARAVKPIMLTVLAIFFVSLLRDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P5</accession>
    <name>D4M8P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted periplasmic or secreted lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_10040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10040"/>
    <dbReference type="HOGENOM" id="CLU_164851_6_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-639-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="71" mass="7779" checksum="2326DE3CF52D7DD2" modified="2010-05-18" version="1">MPELRGFSGQAVVGILQRMGFDLRRSRGSHVVLRRDGAVCVVPMHNELAVGTLRSVLRQAGVSSEEFLKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S2</accession>
    <name>D4M8S2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome biogenesis GTPase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_10580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.266"/>
    <dbReference type="HOGENOM" id="CLU_011106_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-673-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="268" mass="28802" checksum="400EB96352F0F054" modified="2010-05-18" version="1">MARGGRKLAELVEKLDLILEVRDARAPFSTSAPLVSAFSRLRPVLLVLAKRDLADPERTGVWLEALGSDARALDLRRKEGLASLRKALSARRPPHRELRVAVMGIPNVGKSMLLNALVGKAQAHVGGIPGVTRSVSWYRNGDLLVVDSPGILDPHAEPGVHQVLSWLGCARAEVLGGFEAAALQFIRFLRSRGLFGAVLGKWEVRELDETPEETLVRIGRRLGCLAPGGAVNMELAARRLMEAFASGRLGPATLELPGDPIGRAGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S8</accession>
    <name>D4M8S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10690"/>
    <dbReference type="HOGENOM" id="CLU_2915848_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-679-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="61" mass="6427" checksum="B53AEC5CA5EE51DF" modified="2010-05-18" version="1">MGLRQPPEGGQPPGPRRGLSGAILDRSRSMADRLIEGKLPDGTEGWDGLASEDLLPGAWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W4</accession>
    <name>D4M8W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11300"/>
    <dbReference type="HOGENOM" id="CLU_2093270_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-715-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="116" mass="13385" checksum="B36F522BABD40FBF" modified="2010-05-18" version="1">MCLNTKIRNHHSRRAHGDRAGFLSQQTDGPHGKRSGQDSHGRKAEYLTRLLENVYLSDIVERRRGRQEQNSLLRIGDSFRKIIIIVRDNIRPRHDEAGITTIGIWNFLLDADSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W8</accession>
    <name>D4M8W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.344"/>
    <dbReference type="HOGENOM" id="CLU_019824_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-719-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="426" mass="45475" checksum="BB943937C1E1BE57" modified="2010-05-18" version="1">MEAILIFSILIVTIAFSIPIGITLGLSTWIMMLFTSNIPMVMIAQKAFTGLDSFPLLAIPFFILAGSLMCSGGISRRLVTLAESLVGWIVGGLAMVTVLACMFFAAISGSGPATVSAIGSFMIPAMKERRYDAGFAAAITAAAGTIGVIIPPSIPFVIYGIVAKASIGDMFIAGIVPGIIIGIALMLVCYFTARKRHYLSMAERPKFSSVAKAFREAFWALLVPVIILGGIYGGVFTPTEAAVVAVAYSVFIGKFVYRELTMATLYDCLKSTALINGATSFLIGLSMAFANYLAMAQIPAHIAQWFTSFAESPFLLMIIINFFLLVLGCFVDNIAAVIILTPILLPVVRSIGIDPIHFGLIITVNLACGFISPPYGINLFVASAISGENIESISREIVPVFCAMVACLLLFTYFPVLTMGLLKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X3</accession>
    <name>D4M8X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.348"/>
    <dbReference type="HOGENOM" id="CLU_018825_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-724-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="AcnX_catalytic_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcnX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="405" mass="44779" checksum="A52E8B962F8B8748" modified="2010-05-18" version="1">MRLTDEEKRILDGAEGVGKQKAMEMLYALALTFDAEKLISIKRAHVALSGQEGDTYWCELLADGGATCAVPPTTNPYWDTDYLTKFYDVTKEELDLANRTGDAYRRIGAKLTYHCAPGVCSNVPFFGEHVAFSESSATPYVNGALGARSNRESSISALAAAVIGETPYYGYHIDENRRGDFLIEVEAEMKDHYDWGMLGHCVGPIAGTRIPVLKFKKEVRPGPEDFLYFGAEAATSGSVAMYHMVKITPEAPDVESAFGGRKVPAAEVVLTNKDLEAEEDRLTPAVGDINLVMLGCPHYTYSQLLEVERLFNGRKVNHNTAFWILAESGAVELAERSHLREHLELLGVRMVGNTCIDEPCWKSFEGSLGLTDSPKCAYYRERRGQPFAIRRLSECVEAAIKGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y7</accession>
    <name>D4M8Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted Fe-S oxidoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_11700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11700"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.405"/>
    <dbReference type="HOGENOM" id="CLU_050695_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-740-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024521">
        <property type="entry name" value="DUF3641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026351">
        <property type="entry name" value="rSAM_SeCys"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43728">
        <property type="entry name" value="PTHR43728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12345">
        <property type="entry name" value="DUF3641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04167">
        <property type="entry name" value="rSAM_SeCys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3641" evidence="6">
        <location>
            <begin position="192"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="326" mass="36111" checksum="BEF0B79427B808CC" modified="2010-05-18" version="1">MTFAGRDDPLACVPPFRGKLPDPRVGQTLERLDVLQVNVGRLCNLACRHCHVEAGPNRTEVMSRSTMEHCLRVLAAWGFRTLDITGGAPEMNPDFRFLVDRGTAAGVHVIVRTNLVILHESGYDDLPEFMAERGVEIVCSLPYYSERDCDRQRGAGTFRSAISMLRRLNELGYGKDDRLALNMVYNPGGAFLPPPQASMEQEYKLKLGAEYGIVFNRLFTITNNPVGRFGAFLVRSGNMAGYMRRLHDSFNPVAAEGMMCRSQLSVGWDGRLYDCDFNQALDWTVEGTDRIGDLRGDRPSRRNIRLGNHCYACTAGSGSSCGGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D4M920</accession>
    <name>D4M920_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thrS</name>
        <name evidence="12" type="ORF">SY1_12090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.444"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="264"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="9">
        <location>
            <begin position="240"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="633" mass="72799" checksum="E6EC956AB24B809A" modified="2010-05-18" version="1">MLKFEGSNGKSCEFDRESVRASEVLEALGLQKKAIAAKLDGAAVDLNREIRAGGRVEPLTAADEEGLDVLRHSCAHLMAQAIERLYPGTHFGIGPCIKDGFYYDVDATGTITEQDLPAIEAEMRKLTGAAEKVEREEMRREDALKFFKDRGDPYKEELISELEAPTVSLYRQGDYVDLCRGPHVPDTSVIRNFKLLSVAGAYWRGSEKNKMLTRIYGTAFATPDELKAYLKRMEEAKLRDHRKLGRELDLFSLHEEGPGFPFFHPKGMVVMNTLIDFWRREHVRRGYQEVRTPQILDRELWLRSGHWDHYRENMYFTEIDEKPFAIKPMNCPGGILIYKTQLHSYRELPMRIGELGVVHRHERSGVLHGLMRVRCFTQDDAHLYCEPSQIQQEVMGIMDLCRYVYSDVFGFKYAVELSTKPENAMGSTEQWEAAENGLRAALEQSNTPYRVNEGDGAFYGPKIDFHLEDCIGRTWQCGTIQLDFQMPERFDMHYIAEDGKEHRPVMLHRTILGSLERFMGILIEHYAGAFPYWIAPVQAELIPISEAHRAYAEELRKELMSWGVRTETDSRDEKLGKRIRDAQLQKVPYMIVIGDKERDERQVAVRERTKGDLGSMSLEAFQKLLSAEFNPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M935</accession>
    <name>D4M935_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_12280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12280"/>
    <dbReference type="HOGENOM" id="CLU_085305_3_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-788-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="130" mass="14026" checksum="51166F84D35E240C" modified="2010-05-18" version="1">MRTRPRRKVDLDITPLIDVLFMLIIFFVLTTSFVQGRVEVDLPRGEGTPPREDRTLLVSVKADGTVLWDGTPAASADVPTLAARAVAESRDVLLAGDRAAPYGAVAELLELLRHEGLDRAGLALRGVAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M941</accession>
    <name>D4M941_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain</fullName>
            <ecNumber evidence="3">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_12400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12400"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.479"/>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-794-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="188" mass="20845" checksum="653AD985E529C995" modified="2010-05-18" version="1">MAQSSWEGQERRASGRRIYEGRILNLRVDEVTMPSGRTAEREVVEHRSAVGILALTGRDSVLLARQYRYAVGEETLEVCAGLIEPGEDPRVAAERELQEELGVKPGRLQEVGGFFSSPGFCTEYLTLFLADDLQNSRLPQDEDENVSAVEVPYGEVPGMMADGAFRDSKTFAALAWLMAREGIPPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M965</accession>
    <name>D4M965_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12900"/>
    <dbReference type="HOGENOM" id="CLU_2329660_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-818-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="98" mass="11032" checksum="9FD714EBF1476972" modified="2010-05-18" version="1">MPEGYAMYTALHKTELGKLNSAVQNLDIAVRAIRPVVIVLSLKFRVAAGFYALFYTPKKILIGIIQVFKSVLQGTFIRFSEPVQTLLKNCERFVLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M977</accession>
    <name>D4M977_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted metal-binding, possibly nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13140"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.543"/>
    <dbReference type="HOGENOM" id="CLU_100236_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-832-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="191" mass="20940" checksum="E7603D94770BE105" modified="2010-05-18" version="1">MAQKKNQTLRCLIALPPRGDCESRMEESWRLPIEEGIDFEGQHFDAPEGGAACATAQWLEPSLLSVSISVSAKVTAPCARCLKETPLEISDVLMYLYYSRGLELGRDTELASDDGFMPVEVDYLDRVLDVGPQVEESLLLLLPTKVLCREDCAGLCPHCGADLNEGRCSCVGGEGDPRLEALRFFSPDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M986</accession>
    <name>D4M986_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Permeases of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_13250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.561"/>
    <dbReference type="HOGENOM" id="CLU_033863_21_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-842-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="173"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="374" mass="40006" checksum="5AAA71FDDA84A5B7" modified="2010-05-18" version="1">MEKERAPLIKEGVANPTDETTAQGRISARAAALIADLALLLCALLWGGSFTVVKVLLDLYPPNWLLFLRFSCGSALLLLFFHRRIGRMSRQAVAGGVVIGVALFGAILCQTLGLLFMAPGRQAFLVSTYVLFVPLLLWLFRGLFPGWHTLAATCTCLIGMALLTSDLSGPLGRGEALTVLCALFFALQIIAISRYSAQCDPISLTFVQFTVLSLLTLAAALLFERPLQFHWRRGLPELAFAIVFCTFLCYLVQICAQRYTKASHAAILMSLESVFGLLWSVIFLGEPTSLRMLFGCLLIFLSVLLVELEPLLKRGRCPGGPSARPDTASPRSPSAPSSGGPQGPGTCSAASGAEGAPAAPAAPTPAAPRGRERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M999</accession>
    <name>D4M999_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphopantetheine attachment site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13500"/>
    <dbReference type="HOGENOM" id="CLU_2682440_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-855-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="74" mass="8070" checksum="FAD93FFC263E6FC6" modified="2010-05-18" version="1">MQVIAQTILQIASDVLGAPLAEETVMTDVPEWDSLKTLQIVMALDEAGLSIPLERIAEVRGVPDLIRFAQQCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A1</accession>
    <name>D4M9A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13540"/>
    <dbReference type="HOGENOM" id="CLU_2734185_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-857-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="71" mass="7297" checksum="114EB200C8E6FBEB" modified="2010-05-18" version="1">MSLSEKSWAFVAGLAAGIGAACFVKSKAGRAAAVAVAVKGMKLKEQVAGFAERAKESLEDIAAEARQKADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A6</accession>
    <name>D4M9A6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13600"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.593"/>
    <dbReference type="HOGENOM" id="CLU_046006_5_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-862-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="146" mass="16208" checksum="B1783F09E98B9950" modified="2010-05-18" version="1">MKVHHIGYAVNELESAAEKFHRLGYSPSGTPVDDAIRGVRIQFFEDRCGVKVELVAPLKESSPVSGWLKKNGNSPYHICYESLDIERDIAAMQEQGFMLLERPAPAPAMGQRRVAFLYSRPTGLLEFVENVHGPLDSGPERNGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C8</accession>
    <name>D4M9C8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_14020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14020"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.634"/>
    <dbReference type="HOGENOM" id="CLU_009736_5_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-884-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="5">
        <location>
            <begin position="81"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="6">
        <location>
            <begin position="344"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="7">
        <location>
            <begin position="446"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="547" mass="60181" checksum="B628085335305CDD" modified="2010-05-18" version="1">MDSNLKLFEMGESTRSLARCVPCSELTAMVLQMMQQGGVMDIADAQDWMNPKFERLLDSLDLGAASAVARDKWNAKSSLGNVLIYGDYDTDGISSTVLAMEIFRHKAVQVRYFIPRRDVQGYGLNAEVLEQVVRGGCNTLVVVDCGTNDSEMLEDLERRGLDVFVFDHHAVAEAPAFQAIVNPCADGGGKARKLCATAVLWCWAWKEGILPRDWLKYALDLVALATISDCMPLNSLNRSFVRRGMRLMRTNPRRGLGALFSRLRLNARQITEEQLSMRVIPCLNAPGRISCADVSVRALLGVGGDDAVYECAGELIKMNRRRQMISERIAGNIRESGEDDRHVMFDESWPVGVLSGVASRICAQRRSAVALAAPVGEKVRGTLRVPTGGNAVGILSEISDLLDAWGGHRYAAGFSVLARNWDEVEGRLEGLLADVGVEDEVVSAINLSPARISLDDWRTVTALGPFGNDNPCPLFYCASSGEDRVEPLGKDGKHSAVRVDNVKLLAFNAAPDLQDTSGIKGWVYHPRLDYWRNEEQIQFILDYAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C9</accession>
    <name>D4M9C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14050"/>
    <dbReference type="HOGENOM" id="CLU_012300_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-885-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="222"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="294" mass="31944" checksum="CEB4712DE183A000" modified="2010-05-18" version="1">MINGRIVPLSTQLHNSDIVKIITSPQGSPSQDWLKIARSSKTRSKIRNHFRQAEKTDRNEKIARGWEALEKELRKRGLTVENQEDFAPGLNKVARDLGLSGKDDVLAAVGAGTSGPSTVAQKLVLAYLQQHHPADDLSTLVKENPPVRRHDSDIIVEGEGGVSVVLANCCAPIPGDAIVGYSTRTRGITIHRIDCPNILNAQMGRVVQVSWGRSSDKLYTARLKAEAVDRANLIRDAAQSIGLGGGSISGIKASTIGNSLMRMKIELRVRDLEHLYGVIAKLNAVKDIIEVTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D4</accession>
    <name>D4M9D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14100"/>
    <dbReference type="HOGENOM" id="CLU_1700587_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-890-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="152" mass="17083" checksum="865441DF72B7CDEE" modified="2010-05-18" version="1">MEFVGLWLFQDLIEVLLLRVTQAPELFLLGVVYRLLTLKEGEERLWAIWTAFVGGLLWDLRWVGIPGFFTLGYVAVVMLVLWMWSAIPSQGRTMFVAFLLLEASLVIPPLIPVLIVGGGVSGGFFLVQQLCSLPALLLCLHLYSKHMRSLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E7</accession>
    <name>D4M9E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="16" type="ORF">SY1_14530</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.691"/>
    <dbReference type="HOGENOM" id="CLU_028104_2_1_0"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="13">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="15">
        <location>
            <begin position="115"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="14">
        <location>
            <begin position="317"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBL28492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="497" mass="53071" checksum="AF1C72A150D48983" modified="2010-05-18" version="1">MVTELEGVERIHLMGMGGAGMASLAKLLSGMGFQVSGCDLSRGESVQELEALGMECLPGHSRDHVDRFDPQLLIYSSAVDEDCDELEAARARGVRTAGRGRALSWLFNAASGVGVAGTHGKTTTSSMLSLVLSRAGLAPTLYVGARMRDMGTNALLGEGRLFLAELDESDGSFELFRPAVSIVTNVDWDHVDHFPSFEDVILAFARFASGRKEGAPLIVCAEDEGAQRMLEGLRGPLLRYGWGRSWDWGAFDLVPRATGGISCSVCRKGKVLGPLELSVSGEHNVLNALAALAAADVLGVPFEKAAATLKDFHGAARRLQTKGTLGGVTVIDDYAHHPTEIAATLSALRGIYPNRRILLLYQPHRYTRTAALVEPLTAALSGADEILLLPIYSAGEPPQQVSAEAIVERLRRAGKRIAFCRDEDDALRAVRALSQDGDLLLTMGAGNVFRVGERFLDGGTKSFPEGRSEGVPDGTRGRACKDGEGRDGLRSGIRADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F4</accession>
    <name>D4M9F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_14640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14640"/>
    <dbReference type="HOGENOM" id="CLU_063199_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-910-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="228"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="291" mass="32097" checksum="994EF0E8AA0D8341" modified="2010-05-18" version="1">MAKETLSSLRNLCAREWRALVVLVLANVVYAFAVAYCTLPYRFPDIGVPGIAVLTNYLFGISPNWMIVGVNLMLIYWGRRDLSLHFLALTVFSVVVFSGFLAVFSRFPFLITEDKFMAAVISGFLKGVSMGAMFNVGGSSGGFDIAAAVLRRRYDLEVGRFSIIYNVVILALSLGVVGLEPVVYGVVSVYICGVMLDNMTRNFDKRKQALIITSIPDEVSRFITATGRGVTRLDGRGVYTGEPRPVLLSLLGPRQVANLKRFLKEKDPHAFVSICDASEVLGQGFKNWRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G4</accession>
    <name>D4M9G4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SY1_14790</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SGP1</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14790"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.716"/>
    <dbReference type="HOGENOM" id="CLU_035008_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-920-MON"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="20">
        <location>
            <begin position="111"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="21">
        <location>
            <begin position="299"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CBL28509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="378" mass="41879" checksum="2404F990B585D286" modified="2010-05-18" version="1">MDIAEVRSKIDDLDQRMLDLFLERMSLMGEVAKYKEAHHLPIEDRAREREVLARVMDRAGDMEEYAFYFFSRLMSLARARQNEFLSSPSKVRALVERAVARVEDLFPKTGSVACQGVEGSNAQAACDKLLPRGRILYMKTFKAVFDAVGSGLCQYGVLPIDNSLNGSVRAVYELLRERRFFIVRSTRLFIRHVLMAKPGVKLSEIRNVYSHPQALGQCSDFLDSLEGVEAIPYPNTASAARMVAESGDRTAAAIAAPGCAALYGLTPLKEDIQDNDNNQTRFICIAKEPVIYAGSNHLSVILACENTPGALNDVLSKLAAHGVNMNKLESCPVVGRNYEFIFFLEMDGSVQDAGVLSMLEDLERSCPSFDLLGNYAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I0</accession>
    <name>D4M9I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15020"/>
    <dbReference type="HOGENOM" id="CLU_013386_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-937-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="268" mass="29570" checksum="46395DF0DAA6FDED" modified="2010-05-18" version="1">MHPVLFRLGSLQVDTYSVLWFLALSLAILWSVRRFPLYGVDDGVGRHVIGWSFLWMLFGARAMEYLRNAPDYIADPSLFLDLKHGELSEVGAFLGAFLAAMALCRRNPKAPFQSLCGVVALPAALTMLVGRWGCFFNGCCVGIASKCALALHFPRDPIGVARHPTQLYYSAAAAAMLLVLYLVERALIRRALRQGEDLQESAGARGGAVTSIGLMLYAAMRLSVDVVRADAPVDGLSPSHWILLGALPLELLWLWRSLRTLKREDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I6</accession>
    <name>D4M9I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein involved in formation of curli polymers</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15110"/>
    <dbReference type="HOGENOM" id="CLU_577161_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-943-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005534">
        <property type="entry name" value="Curli_assmbl/transp-comp_CsgG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03783">
        <property type="entry name" value="CsgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061850" evidence="2">
        <location>
            <begin position="24"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="473" mass="50073" checksum="29A2F66DEB0F6CB5" modified="2010-05-18" version="1">MRMRKSVVTALFALALFAVPCRAQEEKVRIGVLQFESKTSGVTQQQANAVMDLMTRALASSRSISVIERDQLDKVGKEIRLGQSGLVDASTAAELGRVAGVQYILLGAVTELNKKASGGAIPLFGSIGIATGSEEAQATIDVRIVDTSTAEVRLALSETGYSSNETSGLYVGGAVLAEGTFDGLESRAISDSVTRLAARIRGTLAGESSHVLSVADKEATIDIGSSMGAKEGSLYLVYADGKAILDMNGETIGQERLALAVLKVREVAPAYSNCTFVKGGKAALVRRGDKVEPISNRMIKSLKYASSRPSASSGTFDQIFGNAPQDGAVPADEPAPTGEGKTPAPTAPEQPKPADEPAKGEPRAIPGFDPNQSTDSKVIETYALSGGDKNLLGIMQRNAYNKFKNGKYKDAYAEFCRAADAHPTVNYLSAYWAGVSAHKLKKADEALEWIDKALAINPDYTPAQDFKAKTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K0</accession>
    <name>D4M9K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">IMP dehydrogenase/GMP reductase</fullName>
            <ecNumber evidence="12">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SY1_15340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="12"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.793"/>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-957-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="167"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="503" mass="55421" checksum="E0BC91076A749A1E" modified="2010-05-18" version="1">MAFFYEEPSHTFSEYLLVPSYSSAECIPSNVSLRTPLCRFRRGEEPPVSLNVPLTSAVMQSVSDDRMAVALAREGGLSFIFCSQPIESEAEMVRRVKRYKAGFVANDSSIGPDETLADILALKDRTGHTTVAVTHDGSLTGRLLGIVTSRDYRVSRMDASAPVRDFMTPIDKIVFARDGLTLSEANDILWEHKLNALPVVDNEGNMVAFVFRKDYDMHKENPLELLDAQKRYAVGAGINTRDYEDRVPALVDAGADVLCIDSSEGFTEWQRRTLAWIRGRYGDAVKVGGGNVVDEEGFRFLAEAGADFVKVGIGGGSICITREAKGIGRGQATAVIEVARARDRYFEETGVYVPICSDGGIVLDYHITLALAMGADFCMLGRYFARFDESPTNRVMVNGNYVKEYWGEGSSRARNWQRYDSGDSASIKLSFEEGVDSYVPYAGTLRENVTETLSKIRSTFCNCGALSMAEMRRKAKLTLVSPVTLVEGGAHDVILKEAVKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K5</accession>
    <name>D4M9K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15400"/>
    <dbReference type="HOGENOM" id="CLU_1624724_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-962-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061037" evidence="1">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="166" mass="18535" checksum="1FEB60F99C3AA8C5" modified="2010-05-18" version="1">MKRTMRTACKTICLAMAALLLTAAAAMASPLVGGGDKGGDEAMERELEGGIHVTFLGAFRGANDDNKNYIFFRFIVEPQQDTTLKVDGNSFFDDNGNEFNWNYDAYIGNASTREREIIGGIKTPVVFLYHMDASYGNPFLARMTFYFNGNELVFRNVQVQDKSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M3</accession>
    <name>D4M9M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail tape measure protein, TP901 family, core region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15790"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.849"/>
    <dbReference type="HOGENOM" id="CLU_006757_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-980-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10145">
        <property type="entry name" value="PhageMin_Tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMin_Tail" evidence="1">
        <location>
            <begin position="183"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="832" mass="87309" checksum="62B6ECBA17330395" modified="2010-05-18" version="1">MKNLGIGLVIGASLASSVGGTFKSLDKSIGQLQAKAKDVKLGIAAGEKWKDLRGEALKLSSALQAGKLDTAGIARFNQLKAATKEAEAEAKKYGFTLGGLNKQLGTMQRFSAVQNGFLRRAEARDARKQERGELRGRLAGTVAVGTAMFAYPLKAAMDFEQGMAEVGAITRADDADMARLTENAREMGRTTKFSATQAAQGQKFLAMAGFKTNQIISSMPGMLDLAAASGMDLGRTADIASNILTGFGMEASDMTRVANVMALAFSSSNTDVEQLGYAMKYAAPQAKALGFSIEQTAAIVSKLSDAGIQGQMAGTTLRGMIDSLTDKGNAKKLKALKVDVVDKKGNLRDLGTIIKEMDKRMSAKGWGSAKRASFIKDVFGARAGTGANAIWDAVLSGSLEELTQKYINEQDGAVRRMADKINATAKGSLTQLGSALESVGIDLGNVLLPPLAETAKGLASIVSSVSQFMQKCPVLTKWVVGLGAGFLGLKAATLATRIGWSHLRDGGSIALDILQRVRPSVIANSLAMARMRGEGSALKGMFTVLKGGIGSFVSGASADLKALGGAVKWLWGLCAAHPFIAIGTAVAAVAIAVYTYWEPLKEWLGAFWEGIKGYWGKSVEWIKTSVSGLGDAIKYPFEVAFGWIESTIGKIQGAWNSFMSLFGMGVEEINTTPISITTDLGSAAAPGISLGGLQGGDIVGHASGGLINRPVVSWVGEDGPEVVVPVGSKHRQQGLFWLGKAASALGMSLSEKGDGASASWADRLREFSAAVMAAPQPALAGAGGMTNNFTINPAPGMDEQGVADLIIRKLEDWQRGQATKQRSSYRDDAFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M7</accession>
    <name>D4M9M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.855"/>
    <dbReference type="HOGENOM" id="CLU_558673_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-984-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="488" mass="51910" checksum="6A9FF825B723C2EE" modified="2010-05-18" version="1">MVTTNILRYGLDEAVLDRRGMIRTRDGSELDCSGATSVEGIEVGGSEPHGTKRRVAFRVGGAWGVLEPSGTPGTALFVPFLEQGISANSVIDEGNTADELQAFSSVPDFAGKKVGLAVALCAKLDASEMPTLSLALKCRNVNDTFVKVLTSPELDFGTASEISSARVDQASSNGGSVSVKARLTLQDGTVTDWLNVSEIEGRAARKVQYQATLQAETIGTSVAVLNSVLTEYTRGVGVISGKGTVEIVSVTRNWNIPLRSLRMRVRHARLKDSVLSCHVAFRDLPKTVVGENVGVGTGETATHQLAHVGGLHHDSLRVYFDGVRQYAGYEFNAEVGRVTCAAPVGAVVTVDYEYGWGMEEWQVMRNNGTVPGLDFDATEFVYALPPSSTPKSICAVKIALETTGGTERGEALGEGAGALRSYPLAHVAKQGSPVVYSDGVRLPDTAWSLSLDGTTLRVFASSGAALTADYEWLSETPKVRQFVAVFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q1</accession>
    <name>D4M9Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mu-like prophage FluMu protein gp28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_16150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.885"/>
    <dbReference type="HOGENOM" id="CLU_030701_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1008-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010332">
        <property type="entry name" value="ATPase_terminase-su_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035421">
        <property type="entry name" value="Terminase_6C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06056">
        <property type="entry name" value="Terminase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17289">
        <property type="entry name" value="Terminase_6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_6C" evidence="2">
        <location>
            <begin position="358"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="532" mass="60721" checksum="2FC721EBA6883731" modified="2010-05-18" version="1">MAYSEAIKREAKRLYCSGWSCNEVAEKLNLNPDTVFRWRARYQWDEETADESIEGVKRQIAAIGASDEPLSEAQARKLDKLTRAVERMERSAAREAREKKGRKRKKGDPPPGLDAQVIGDIKEKALDKLYAYQRSFLLDDSRFRVCLKSRQIGFSFLLGLEVLLGAIERGDNQIVISASQDQSDIVRNYAVKWCKDLDVDYLEDGGNIIFPGGAIAYFLPCNPRTVQGYTGDVYLDEFAWHMRGRLMWQAAVPAATTKGKRLTVTSTPYTETDMFGEIVTNPDKYPRFSRHTVTIYDAVKDGHQVDIEELRGLFDAITFAQAYECRFFADELCLLQPDEVRAVLDDDCLRHVSAWVNGGVDIGRTKDVTAIVLAEQLQVEAEKLVFVRHMETLARMAFDGQRSHMAGLVEGWKIRRLAMDATGIGMQLSEDMQRLYPGKVERVHFTREKKEEMALSVKKLFETQRIRIPNDRDLVMQLHAIKRKPTEKGFTYDADRNEQIKHADLFWALALAVKEFGGRRRVLTARNFKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q3</accession>
    <name>D4M9Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16180"/>
    <dbReference type="HOGENOM" id="CLU_2081374_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1010-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="117" mass="14549" checksum="17A6079766D71EB7" modified="2010-05-18" version="1">MSRRELLEHIAAVSGTFWIEDGWEPWERMNDWPELELLSAFDFLRPELSEEERGILDGWIEKYAGWREQGIFFQRYRETKGSRFTWKKYRERMEEEFGRLIPRSHWWFWPDDKRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S5</accession>
    <name>D4M9S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase and related Zn-dependent oxidoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16500"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.920"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1032-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="16"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="318" mass="34204" checksum="E4D16B134F9CAAC0" modified="2010-05-18" version="1">MKTMKAVLLNGVTESGDIGLSEVPIPEVRPGWVLIKVRAFGMNHSEQILRLSEIRAEYIQKPIVPGIECVGEVAAPSDSGLATGQKVVAMMGGMGRSFNGSYAEYALLPVQHVFAIESDFDWTTLAAVPETYFTAWGSLLECLKLQPDDTLLIRGATCALGYAAIQMAKAMGCRVIATTHRENKLKLILDADEQILDQGKLTGVVQGVSKALELVGAKTVKDTLTAVERGGIVCNTGVLGGVYALNGFDPIKDVPNGVYLTGFHSNWPTQQVVDDIFRFIEDKNLVPVYGKAFSFDDIQDAVAAQDEGSVNGKIVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U8</accession>
    <name>D4M9U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17090"/>
    <dbReference type="HOGENOM" id="CLU_686823_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1055-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061859" evidence="1">
        <location>
            <begin position="29"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="395" mass="43765" checksum="C8AA05EF983CE10E" modified="2010-05-18" version="1">MRDKKALILMATLWLALFGAVAPERAPAAESPNWMWTVFVVPPQGGWETEAGRSILTVLAWHEANIADSGRGIGGHDVHFVPVAEAGEASDVRLPLDERTAAVMSFAVPEVDRGLIQRLGGQKVPLLLAGGEELLIDKDGRPLPNVFALDMFRDYRCAAFANFAAQTLHRKAHVALAASRFTVDQEREAKIAYSLLDLAGFMPMPFWMDASVSDSFSMVAQEIRSVSNGVLIAFIGGMGAREMWRGFMRTETPWQLWNCAAPEPLYLSCKGMLFADQNLFLSERGGFSTLKRQLWDTRAMQVKDLVPAGRANALAEWLTRGIRALPQPVDRLDRDALLTALGRVRGIPFGAQTLDVTPSLHRPVSRQVYIAEVRDRRFILKDTLMTDALPYVPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X5</accession>
    <name>D4M9X5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_17590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17590"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1083-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="279" mass="29696" checksum="ABD1F984B5551AC3" modified="2010-05-18" version="1">MSEHCDHNCDHCAAGCAAPAAAARAAAKQENRVARVVGVVSGKGGVGKSLVTALLASGGRRRGMRTGILDADITGPSIPKMFGLHEKVFSDGKAILPAVTRDGTEVISMNLCLPREEDPVVWRGPVIAGTVTQFWEDVDWGELDCLFVDMPPGTGDVPLTVFQSLPVSGIVVVTSPQELVGLIVKKAFHMARLMKIPVLGIVENMAYFECPDCGKRHHIFGRGHAGEEARALGVGAVAHIPMDPHFAELCDRGRVEDLEGPWLDDILDAIQRSGKGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y6</accession>
    <name>D4M9Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CRISPR-associated protein, Cas2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_17740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17740"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1043"/>
    <dbReference type="HOGENOM" id="CLU_161124_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1094-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="83" mass="9781" checksum="AFE15A5AABB08FF6" modified="2010-05-18" version="1">MFYDVGEKRVGKVLKTARRYLTWIQNSVLEGELTPASMAALKMDVHKVLDLQYDSVLFYMWRTERYMSREVLGVERGETDFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z5</accession>
    <name>D4M9Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components</fullName>
            <ecNumber evidence="5">3.6.3.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_17930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.34" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17930"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1103-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="258" mass="27829" checksum="E9426529DF67A1E7" modified="2010-05-18" version="1">MSAACFRLADLTAGYGDRRVLRGLTADLPSGRFTALIGPNGSGKSTLLRTMAGLLPYGGGLTLLGREVRGVSRRQFGRLVGVVPQHFRPLYPFSVWEVIGMGRLPHRGFPARPLNAEDEALIEAAAERVGVRSLLSRDVTSLSGGEAQRVVLACALVQDPPVLLLDEPTSALDPHQAARVLGLLRELAREGRTVAAAVHDVNAALPFIDDYLALKEGRFCSQGPVEALDGRVLESLYGAPFLSYRSERGDVMWRALCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA09</accession>
    <name>D4MA09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_18460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18460"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1107"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1117-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="82"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="284" mass="30536" checksum="D944B6C13216DFCD" modified="2010-05-18" version="1">MILKKNSMLRLTLIRLRRNKLAMIGLAVLILLILVAVFADYVAPFKYSRQNLREVLQYPNAKHLLGTDEFGRDVLSRLIYGARVSLQVGLVSVSIALVLGGALGAIAGYYGGWLDNLLMRLMDVQLAIPSTLLAIAIAAALGPGLFNLMIAVGISSVPRFSRLLRASVLSVKEMEFIEAARAMGASDFRIILLHILPNCCAPLIVQATLSVAGAILSSAALSFIGLGIQPPFPEWGGMLSSARGYLRGSAYLSMFPGIAIVVTIIALNFLGDGLRDAMDPKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA24</accession>
    <name>D4MA24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components</fullName>
            <ecNumber evidence="5">3.6.3.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_18660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.34" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18660"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1127"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1132-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="262" mass="29154" checksum="780B7C6AF46A5310" modified="2010-05-18" version="1">MIFAVENGCFGYRRGSILLRDISFRIEPGEVLAVLGANGAGKTTMLRCMMGFLPWRDGGTFIDGRELSSFSPRQIWRKMAYVPQARTAGFPYTAYEMTLLGRSAHLGAFKQPGPDDERIAMECMEETGILHLKDKPCNRMSGGELQMVLIARALTTQPSLLVMDEPESNLDFHNQLVILEVIRHLAHDLGKSVVLNTHFPDHAMRLADKALLLNRDGTNLYGPVNEVVTVENIRSAFGVHAAIRKIEDRGELYDIVVPLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA35</accession>
    <name>D4MA35_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRISPR type III-B/RAMP module-associated protein Cmr5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_18830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR system Cmr5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18830"/>
    <dbReference type="HOGENOM" id="CLU_120836_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1143-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023101">
        <property type="entry name" value="AF1862-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010160">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09701">
        <property type="entry name" value="Cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158568">
        <property type="entry name" value="SSF158568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="109" mass="11988" checksum="6DB6FF7D01D4BACD" modified="2010-05-18" version="1">MGIRTKEQQMAQAAFERVQGRNSGFEEYSSFALAFPSLVHSCGLAQALAFAQAKGRADYLSDLENVLGEGGDLCARSREAEVMEYMRLSRRALAASSWIKRYCQAKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA62</accession>
    <name>D4MA62_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_19240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19240"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1189"/>
    <dbReference type="HOGENOM" id="CLU_021594_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1171-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="4">
        <location>
            <begin position="11"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="240" mass="26168" checksum="FB81539EB600A1D1" modified="2010-05-18" version="1">MEYRVEHDSMGTVNVPADRYWGAQTERSRQNFPIGVGLETMPREVIHAFGILKRGAATANRALRPERMTEEKCRAITQAAAEVAEGKLDDHFPLVVWQTGSGTQSNMNANEVIANRGNQLAGRLLLHPNDDVNMSQSSNDAFPTAMHIAAVLALEDRLLPAVEGLIATFRRLEAENEGVVKCGRTHLQDRDPHPLLPGDLRLVQQPGARRRNAARRVGPAARAGPGGHGRGNGAERSRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA63</accession>
    <name>D4MA63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malic enzyme</fullName>
            <ecNumber evidence="6">1.1.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_19250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1190"/>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1172-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="5">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="4">
        <location>
            <begin position="160"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="391" mass="41770" checksum="6E33FD4164FD9096" modified="2010-05-18" version="1">MDYAKESLRLHGEWRGKIEIAVRVPVQTKEELALAYTPGVAQPCLEIQKDVDRSYDLTRRWNLCLVATDGSAVLGLGDIGPEAGMPVMEGKCALFKAFGGVDAFPLCIRSHDADEIVETIYRISGSFGGVNLEDISAPRCFEIERKLKERCDVPIFHDDQHGTAVITLAGLTNALKLTGRTLPEARVVINGAGAAAIAIAKLLIGAGARDVTLCDRTGVLHRGREQGMNWIKAEMAEVTNPAGIRGTLADAMRGADVFIGVSAPGAVTQDMVRSMAKDPILFACANPTPEIFPDEALSAGAKVVATGRSDLPNQINNVLAFPGIFRGAFDVRARDINEEMKMAAANALADLVDEASLRPDFIIPNAMDSRVVHAVSRAVAEAARKSGAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA66</accession>
    <name>D4MA66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_19280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1193"/>
    <dbReference type="HOGENOM" id="CLU_046381_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1175-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="108"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="352" mass="40058" checksum="490A85FE2BB1CF06" modified="2010-05-18" version="1">MRALNYKTEYQKLLTPEIVSYLAQIHEMKGRQNLFVEARKDALAKLLEIAKIQSTEASNRIEGIVTTDDRLKKIVMNKTTPRGRSEREIAGYRDVLNTVHENYDYIPIRPGMILQLHRDLYKFSNTSIGGSFKSSDNGIAEELPDGTKRVRFQLVPAWETPEAMDALCNALREALADPELDPLLLIPMFVLDFLCIHPFNDGNGRMSRLLTLLLLYRSGYFVGKYISIERLIADSKGTYYEALQESSAGWHEGHNDYLPFVRYMLGIVVAACREFAARVDTLVTKGLSKPDRVRGIVRNTIGRLTKTQIMNQCPDISQKTVERALADMLKNGEILKIGGGRYTSYAWNWEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA94</accession>
    <name>D4MA94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-ACP thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19710"/>
    <dbReference type="HOGENOM" id="CLU_1576193_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1203-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="169" mass="18933" checksum="3D2B3581015D626E" modified="2010-05-18" version="1">MYLRELTVLPSDASCRGRLKLHSLLDYLQDTASLAVRELEGTSSELLARGYAWVLLRYQVEVLAPLPALDERFVVGTFHDVEHGYNTLRVFNVDRPDGTPLAWAKTSWLLLDLASGRPVRPKAHLPRIDERYTGPIDPDFPDVPPPNRTRLAPKSPGPSAFTTWTSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA98</accession>
    <name>D4MA98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type II secretory pathway, component PulF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_19860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19860"/>
    <dbReference type="HOGENOM" id="CLU_035032_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1207-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="64"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="257"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="382" mass="42093" checksum="702EBE319B084C69" modified="2010-05-18" version="1">MPYFTYSGYDARGKQTRGTVEASSSMQAVERLTERGIVVVDVAAAERKRSGRPKLLSLDAHIFFCRSLASYLKSGLPLADSLRIMAKQARDRHMGPALEKLLAEVEGGRKFHTALAESGAFRESLWRVAESGEQSGSLISVLAEAAEQFKLEDGLVRKIRGAMTYPIVMAVVGVGVVTFMLTYVVPKISSLFEDMHQTLPLPTRILIGLSSFIIDWGVWVLAGLLLLFLWMKRRGKKIAIPFMRGINEQLTLALVTSHLSTLLRSGIPLVQALRMASSMDPRARRWLDCAEMVKAGHRFDRALERTGFPEEIVAVVRVGEMGGELSQALSNVSGQCREIAQSRMERLSTLMEPMMVLLLGVSVGFIVLAILTPVFDLAGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF5</accession>
    <name>D4MAF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline-glycine betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_20940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20940"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1353"/>
    <dbReference type="HOGENOM" id="CLU_010118_6_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1263-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="541" mass="58482" checksum="AAD23E45F961BEED" modified="2010-05-18" version="1">MDSKHSAPDVKRNIRWEVFIPAYVVVAIAAVVGVFNKDLLTAASNVFYFWSFDTFGWLYQLSIAASLVLVVAVTCFSKIGGMRIGGRDAKPRYGFWTWFAMALTGGIATGIVTWGVNEPVIYFGNVWGELDTLGIQPNTTRAAIFAIARTYYNWTVFPYAIYAMCGLLVAYIYYHKRDELTVTATLKPLFGKKIASPAASAVIDTLSMLALAIGLATGLAMCITLVVTGLKSGYGIDESLSLFIAIGVVIVLAFTFSSYIGLDKGLKIVGSLNAWFYYGLMILLLLTGPTLYILRIGTAGLAEWLNNFWLWGLDPIDIGGPALTRSWTLFDWAFWVGYAPVTGIFLAMLSYGRTVREYMIVNWILPSVFGFFWFAIWGASAIHMQASGAADLVGAIKSGGAVMALWEFLKHLPFNLGAIVLPVNILVILASFITNADATLTNIGSMCVRNVPIGTEPPANMKAVWGISVGIVSIVMAAFGGGAQGVDGVKALAAVAGFVVLFIFAIQTVAFVKVFFVDKVEMDVSPIFADAGNKHDVESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF6</accession>
    <name>D4MAF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs</fullName>
            <ecNumber evidence="2">1.17.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.1.4" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20950"/>
    <dbReference type="HOGENOM" id="CLU_001681_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1264-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="40"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="766" mass="83832" checksum="311113D49FEC2C4D" modified="2010-05-18" version="1">MLTKTSDPDVKSKKTAENSRRNYKYIGRRIIREDSIDKVRGAYRYLADQLPQDVLIGIPLLSSQPNAIVKFIDASEAQKTDGVIVLTFRDAPENKYNSGEWFPGQNDFPDETILRGHARHVGDHIGLVLAPDEKTARRALLKIRVEYEALPPVVDIGRAEGMAGLLHEDGMASFPGHIEYGDVDAAFAAAAHIESDEVYTQKIHHAALEPHCVLAIPRPEHVIEVHTPCQILFGVQHAISQVLPLPLSKIRVIKANMGGSFGGKQECVFEPLCAWAAWKLRRPVFINTNRTETMVATRTRAAVLGRVTTALDSNGRILARKFDVTADAGAYLTGTKKVMMAMGKKASRLYRIPALRFEGRAVRTSTTPGGACRGYGSPQIHTMTEIHTDLMCRRLGLDPLQFRLDNLVHDGDHDPSGASDIGRARIIECLKEGASRFGWPGCRHPLLSVDGRYSIGAGFACSTHGNGYYKTIYHDMVQMSFCILPDGSAILRTPLHELGNGTTTAVAQIAAEASGIDIARITVTEGDTHYSSFDVGCQASRVIYVCGECARRAAADAVRLLCREASEVYGCRAEFCDGFVLAGEDKIELSEAVRRIMREKKRSIEACCEYAPDKNPASFGVHFAKVSVDKLTGFVHVNRYLAVHDVGQSINRNFVEGQIYGGIQMGIGMALCEELEYGADGMPKARNFDKYHMINMPDMPDVDIMLIEDEEPGGPYGAKSIGEICTVPVAAAVVNAVNRALGTSLTHLPLTPSKIISALKTEPEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL5</accession>
    <name>D4MAL5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="1">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_22010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22010"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1454"/>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1324-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="3">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="344" mass="36026" checksum="9BAD1D3F3614C85F" modified="2010-05-18" version="1">MVPCEVAAGPIRAGGLSLQNPLCLAPLAGVTSLPIREFFTRLGASLTHTEMVSCAGLVRHNRKTLSMLHTSPSEAPVILQLFAPAADVLVRGAEAALDLVHQSGEVPFAGLGINMACPMPKVTKRGAGAALLKSPSDAFAMVRGLKGLGFPVWVKIRRIEAGEAGIEATVRFIEGLLNSGADNVCIHGRTATQRYEGVADRTVHAAAARLFPGFISASGDVREVGDVREYLEMGCVLVMAARGALGNPWLFAEALNALGYAVPEMARDRTPAGRMTALRWLGERAMGTSGEAQAVILLKRLMGGVLRGISGAAELRHQAGCSGSVEEILAVFRRGTEGGNPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL9</accession>
    <name>D4MAL9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SY1_22070</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SGP1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22070"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1458"/>
    <dbReference type="HOGENOM" id="CLU_094161_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1328-MON"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBL28914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="193" mass="21096" checksum="9F67E83F1B1583E7" modified="2010-05-18" version="1">MFLFVSGGVRSGKSEWAERAALALSPDAPRVYLATARVSDEDMRRRVERHRRARSGRGFLTVERERGLTGVLESIPEGALVLLECLPNWAANEMFLEDGSVRGVHEVRGEVLRSTLALKDCARDLIVVSDDIFSDGGHYDAAVEDYVRLLGELHVLLAARADAVVECAFGIARFWKGDAARIFPTAKAVGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAM1</accession>
    <name>D4MAM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22110"/>
    <dbReference type="HOGENOM" id="CLU_044146_7_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1330-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="262" mass="28505" checksum="4CFD4E6B34B50512" modified="2010-05-18" version="1">MRRKYVFFDIDHTLLSHVGTSHIPSETREALRLLKANGHVPALATGRGAFLTHPIARDLGIELLVCADGAHVLNGGRTLHRTCLPEGALDGLRSLAALLPKEVAAMDDCFIYTDNESEDWRTYFEVQAGYACVRPLREMDRAFLGCLMVRPPLRGDYGPFTTPPAGVLIEALHDLVEMRAEGVSKWNGIERVMEHFGADASDVITFGDGLNDVEMLRRASIGVAVAGASRAARDAASFVAEDIDDGGILKACRHLKLIPDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ3</accession>
    <name>D4MAQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, C-terminal subunit</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22630"/>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1364-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="306" mass="32304" checksum="6ED03D94FDBDEF55" modified="2010-05-18" version="1">MTLRKVYRSFVEEALGHGGEFADVALVGDCAPPLWAGQRPYVPGVGEQGLVLMAAGMAYGGRRVVLSGATSFLLGRAYEQIRSAIALTALPVCIVGYDSGFSAGYEGAARQMLEDVALMRLLPGITLLVPSDRDASVALLREALRRRRPAFLRFAEERDVASGEGHEPLCFSGARTLRPGGDITICACGIMVKEALKAADILAQQGLHAEVIDCCCVSPLPGRSILSSLQKTGCCVVAEEHFLAGGLFESVTALAAQEYPVPVLPVTASGGFGQSGSTQNLRDYYGLTATQVVSAAVQAWARRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR5</accession>
    <name>D4MAR5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fhs</name>
        <name evidence="7" type="ORF">SY1_22780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1523"/>
    <dbReference type="HOGENOM" id="CLU_003601_3_3_0"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="558" mass="59687" checksum="262DB98E546DD641" modified="2010-05-18" version="1">MANVPSDIEIAQAARPQPIVEVAKKLGISEDELECYGKYKAKVLPEVLREREKKPDGKLVLVTAITPTPAGEGKTTTSVGLADGLNKIGKRACVALREPSLGPSFGVKGGAAGGGYAQVIPMEDINLHFTGDLHAITTAHNLCAAMLDNHLQQGNELNIDPRRVVFRRVMDLNERALRNIVIGLGGKANGVPRENGFDITVASEVMAILCLSMDLTDLKERFKKMVLAYTYDGKPVTAGDIGAAGAMAALMKDAIKPNLVQTLEGTPAFIHGGPFANIAHGCNSVQATRLGLKSADYLVTEAGFGADLGAEKFLDIKCRVAGLKPDAVVVVATVRALKMHGGRSKKELGTEDLKALEAGIPNLQKHIENVQKFGLPVVVAINRFPLDTEAELALVEAKCKELGASFALSEVWEKGGEGGRELAQKVVEACEKPSHFKFIYDAKMSPKEKMEAIAREIYGAEGVDFTPQAEKDLQVIHELGKDDLLVCMAKTQYSFSDDATKVGRPSGFRITVREVRLSAGAGFLVAVTGEIMTMPGLPKKPAALSIDVDEHGKITGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR6</accession>
    <name>D4MAR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22790"/>
    <dbReference type="HOGENOM" id="CLU_905021_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1377-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="297" mass="33211" checksum="B992091667BE11A6" modified="2010-05-18" version="1">MGEDEVDVEALLDRAYESEDAEEVEALVTRALEIEPDNPEALLLRADLTEDDEERLSILQGALEAVETVLKEEGVGEEAYEDNPLGTVSLALMQRMAFTLYGVGDDERAMELIERLLRHDLDDNGAVKSLYYRILIEQNAWQLILSKTMQDEEHQLGWAYSRLCAAFMLGPKGAERGTAARMFWEALTMSPNVPFYMLGYFAEPVDDSEAEEEDFNFASLYADVWSTSRDLLNWFSRGVILFGLLSGRFGEESGDMLEILTSLGGRQEYEAMGKLPMEGDDVAVIEALAAHHCLAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS8</accession>
    <name>D4MAS8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ORF">SY1_22990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1544"/>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="14"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="246"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="378" mass="41655" checksum="36A2369D344F03F1" modified="2010-05-18" version="1">MFEFKVLAVCPETGARAGELTTPHGVIRTPVFMPVGTQATVKAMAPWELEEIGAQIVLGNTYHLYLRPGAELVAEAGGLHRFMSWAHPILTDSGGFQVFSLADLNRVTDEAVVCRSHLDGSRHVMSPEWSMRVQELLGSDIAMCFDQCGPFPADHGQAEAALVRTTLWARRSQEAHRREDQALFGIVQGSVYDDLRLRSAEEIIELGFPGFGIGGLSVGEPHEVMYHVLDLLNGVMPREKPRYLMGVGYPSNVVEGIARGVDMFDCVLPTRNGRNGTLFTSFGRVNIKGKQYEHDFGSIDPECGCRLCRGFSRAYLRHLYHCGEILAARLCTLHNLSFTLNLAARAREAILDGTFPAFRAEFNAKFVDGPGRDAGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT4</accession>
    <name>D4MAT4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23120"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1557"/>
    <dbReference type="HOGENOM" id="CLU_045089_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1395-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="159"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="338" mass="37808" checksum="0F245A7D1FE1CBBB" modified="2010-05-18" version="1">MINGITLDNFGPISHLEWTGLGPINLVVGGNGSGKTFLLKVLYSAMRTIEEYKRGDDRRTEAEILADKLYWTFQLDRIGDLVTKGAASLSCVVRFNDEDFSYSFGRDTTKQITSLENGIPPRSSNSIFLPAKEILSLQQIILKSREQDKVFGFDDTYLDLARALRQSTQKGKNYTEFAASRQSLEDILGGRIEYDEASGRWQFRKGSQKFPIGVTAEGVKKIAILDTLLGNRYLDLSAIVFFDEPESALHPSAISALLDIVATLASRGIQFFMASHSYFVIKKLFLIAQERKLSIPVLSAQAEDGHWTADDLRSGMPDNAIIDESIRLYEKEVDMALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV9</accession>
    <name>D4MAV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">6-phosphofructokinase</fullName>
            <ecNumber evidence="9">2.7.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_23480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1590"/>
    <dbReference type="HOGENOM" id="CLU_020655_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1420-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="8">
        <location>
            <begin position="7"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL29004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="405" mass="44370" checksum="3F4F3D9B4E01DCBA" modified="2010-05-18" version="1">MGKKMKNIGIITSGGDCGGLNAVVRGAAKTAMQRGIGAYIVPNGYAGLYNLVDFDRLVFLDEERTDHVNSAFAGSDAGHSRVKISKIPDPDKYNRILLGLRKFNLDGLLISGGDDTGSVVVDLAEHGIPCVHAPKTMDLDLQTYSVGGDSAINKIARIVEDLKTTGKTHNRIMIVEVFGRYAGHTAFRGGIAADADCILIPEIVADFDAIYKHLKHYYIRRILNSDVHSGTYVMVVAEGVKGEDGKYFSDSGDSTDSFGHVRLAGAGRYIRTRLEAMMREDPQIHQFMKVSGMYVPGVFEIPEIREVIPGHIVRSGSTSSYDVNFGKQIGASAVILLDEGISGVTVVEVYKGRIRYMPTADAIVPRPVSLEDVTFYEQMDICFGRTPQHYEPVIEEQKGEVERFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6X6</accession>
    <name>D4M6X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_00110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00110"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1"/>
    <dbReference type="HOGENOM" id="CLU_007415_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="495"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="703" mass="75409" checksum="21000C6EE0A95D1F" modified="2010-05-18" version="1">MQEANKALLSHPLRKLFAPESIAIVGASSSLERLTGRTLRYLQSFGYGGAIYPINPKADVISGLPVHRNVTEVEGPIDLAILSIKAKLIPDALRACADKKIPFALIYSSGFSETGDRALQEEVSAIARDGGIRVLGPNCQGLANFAEGIPLTFSGALYEVPRPLPGHVALVSQSGAFGFSSFGVGLEHGVRFRYVATTGNQSDLDAVECADYVLDDPEVRLLMLYLEGLEDGAGFLRLVRKARERDIAVAVLKAGRSPSAREAAKSHTAALTGDDRVWSAVFSQYGVIPMEDIDDIIGIGQVLGAEKRMSGGRSAILTTSGGAGIVMADCLNDVGLSVPVFSHDTRSRIEAAIPPFGASRNPVDMTVQISEQPENFRSVFDAVQEDPELDSIVTSLSMIVGHAGDVMTDTMIESYAKSPKPQAAVWMIDHQHGGSFIERLKTAGIPIFQSFRQCARALRELNRWGAFKPPAAPEVGGNAPILPQWKDAMTEYDAKVFLSRYDIPVTRERLCLNLEEACDAAEELGFPVALKGMAASVLHKTEAGIVALDVRSFEELRGALKTVRKHLADYVGDGAVQGFLVSEMVRGGFECIVGVKRDPVFGPMIAVGLGGIYVEVLGDVSLRHGPVDEEEALNMIRQLKGYSFLSGTRGSKPRDIRALAGIVSRVSRLAAIETDLLELDINPVFVLEEGKGAVAADALVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M705</accession>
    <name>D4M705_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized domain HDIG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.105"/>
    <dbReference type="HOGENOM" id="CLU_056349_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-32-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="182"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="352" mass="39251" checksum="D0C60ED2E5E35C8F" modified="2010-05-18" version="1">MKEKKNSTVREVRQLPLDATFNVLGVVSRLTRKKDRNDKPFWDISITDGTGDLEGKIWGGSNWWNLSGGDRYPLDPLNLGDLKFEGAAVGLQGKVSEFREQTQYNFNDVYYVDQEKYPPHSFVRRSPLSDERMEGEFRALLAEMREPLKSFLEAVFFKHGLWKKFMAWPAAVSMHHAYVGGLLEHSLAVALGAKALARHYADRGYPVDVDLATAGGLLHDLGKLDSYSLNPAPQMTIPGNVAEHIVLGYHRFMVLAEQEGLDDGVALALGHIIVSHHGRREYGSPVLPATQEALIVAASDDLDFKMFCWRSQIDGLEAGHDTTDYIPLLERRFWRGLPAKAASGGGAEEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M725</accession>
    <name>D4M725_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAP-type C4-dicarboxylate transport system, small permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_01040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01040"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.374"/>
    <dbReference type="HOGENOM" id="CLU_086356_9_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-52-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="164" mass="18868" checksum="30094E1621428C0D" modified="2010-05-18" version="1">MFLTRFYSRLMALFRVVVGILFVAIIILTITQVFCRFVLDSPLVWSEELSRLLFVWMTMFGGPVLTYQRAHLAIPELVRSLPEKTQGWLDLLLNLIVAVMLAIMTATSPKLLKVSWHITSGALKLPFTFWRAAAPFGCFFMLCSILIRLPVMIRRVCEKKEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M730</accession>
    <name>D4M730_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid/amide ABC transporter substrate-binding protein, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01090"/>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-57-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="2"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="333" mass="36257" checksum="7B271E62F911BA92" modified="2010-05-18" version="1">MIVDEQNEAGGLLGGRPIELIVYDTKSRNEDAVNAARRLVVNDGVCVIVGDLSSGINIATAPIVARGKVPQISTLGTNPLVTVDNKGNVRPYSFRICFTDPYQGALAADLAYNDLGKKKAAILYNVGSDYAHGLREFFVKNYEKLGGEIVADEGFRGDDVDFRAQLTTIKAAGADILFLPGMGKDMGLAIKQARELGFDGSIVGGDGYSDVMIEIAGDAMKGTHWVSHTYFEDPGMVPIYERFQKRYNDVCKEFVSTAMAADAMYWVFDAIRRAGVDEGPAIAKALEGTKDLKLNHATLTIDPATHNPLNKAGIILRVDDNLERKFYKKVEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M735</accession>
    <name>D4M735_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.385"/>
    <dbReference type="HOGENOM" id="CLU_158611_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-62-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027890">
        <property type="entry name" value="DUF4491"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14898">
        <property type="entry name" value="DUF4491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="98" mass="10975" checksum="989169C9BD425F1D" modified="2010-05-18" version="1">MLNGSGILIGLASFLLIGLFHPIVIKCEYYFSDRVWPVFLVGGLAFCTASLFAEDPTFSAILGVAGFTSLWSIHELKQQTKRVERGWFPRNPKRAPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M743</accession>
    <name>D4M743_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01290"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.553"/>
    <dbReference type="HOGENOM" id="CLU_081251_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-70-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="195" mass="21355" checksum="AAF59C38298EF345" modified="2010-05-18" version="1">MSEGRSAEDRDTASLIRAFVAVTVPDGAARTLELLLTRLVPLGRLRWVTRAQLHVTLRFLGERTPDAIERVRRALAPIAFPPFEVELSRAGAFPSLERPRTLWLSGTRGAAELTALAARLEDALAEAGIPRERRPFVPHLTLARCSGEPLSPALLRALEQVPPVSWTCCGIELMRSRLTPRGAIYTPIPLEGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M770</accession>
    <name>D4M770_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01680"/>
    <dbReference type="HOGENOM" id="CLU_3373918_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-96-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="34" mass="3592" checksum="ECF52088B6E5B3C8" modified="2010-05-18" version="1">MTFQLPKQCAPERRCGLPAAPGMTEGPCGTEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M776</accession>
    <name>D4M776_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GSPII_E N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01770"/>
    <dbReference type="HOGENOM" id="CLU_1432639_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-102-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSE_N" evidence="1">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="189" mass="20483" checksum="8463762289FD14C9" modified="2010-05-18" version="1">MGATRKKIGEILLRSRRVAPEALQRALEEQAKNPQKRIGAILVELGFLTDRQLTEALGLQFMLPVVKVSDYMANIAAQNECPRELMEKFNVFPLEFQERGSVLLIAIADPLDVATQDMLRTKLPIPLRFALAPAQEIREALMEGRMPGAAAVPGMQRGPAVGVPLGGVQAPLGADPRPAGRRPCAAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M788</accession>
    <name>D4M788_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1141"/>
    <dbReference type="HOGENOM" id="CLU_025174_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-115-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="414" mass="45008" checksum="22EA0412FAF92F5C" modified="2010-05-18" version="1">MERFDAIVIGGGPAGLMAALRAAELGERVLLTEKNASLGTKLLLAGRGRCNFTNAEPDPAAFIARYGEKGRFLWSAFSRFGPAETLAFFQKHGVETVTERGGRVFPAEGGGQRVLNALLMLCRKFGVRILRSSPVRSLKVRDGRVERLITEVEELEANRFIVATGGKSYPRTGSTGDGYRFAEQAGHAIVTPMPALVPLKTHETWVKLAHGCNLRNVRVTALVDGKRVDERFGEMEFTNFGVSGPVIMDMSSSVPDWMAQGPLSLSIDLKPALTREKLTERVRRDLEKFSARRFAGALKGLVPGPLIPMILELSDVPEDKPAAYVSSEEAEATADLLKDIRLTVNGLWSFNNAVVTRGGVSLKEVDPATMRSKRCENLYFAGEVLDLNGPSGGFNLQICWSTGWVAGEGAQQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C4</accession>
    <name>D4M7C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1705"/>
    <dbReference type="HOGENOM" id="CLU_095712_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-154-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="222" mass="23405" checksum="68A1D06CA84DDD90" modified="2010-05-18" version="1">MSEHDHMAEWKKGSILIGAPTNLIAAATAFIPVLWLCSTHHCWPDWNVVLTAWGMTAASFGAFYLVEPISYYAALGMAGTYLGFLSGNIGNMRVPVAALALEATDSQPGTIQAEIASTMAICGSIIMNLFFTTLAAVVGTAVVAVLPKFIVTGLTKYSAAAIFGGTLGNFAIKYPLVGVFALGLPLLLHWAIPSIAAWLLIVISVFGSITFARVLYGMGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G9</accession>
    <name>D4M7G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03120"/>
    <dbReference type="HOGENOM" id="CLU_145998_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-199-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025531">
        <property type="entry name" value="DUF4418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14387">
        <property type="entry name" value="DUF4418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="135" mass="14386" checksum="71F90239E13477FB" modified="2010-05-18" version="1">MTRRLAVFEAFLGVLLALTPFVLWPVCSMPKPDGGHMLCWYSGILITAIGVLVVLFSILAWWKSWSFLLAAAAALLAWLAPNDIIHIAGTGWAVGLCGMANHACRAVTMPVVGWIVLAIVLIGIAGLVSGFVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N4</accession>
    <name>D4M7N4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose/methyl galactoside import ATP-binding protein MglA</fullName>
            <ecNumber evidence="4">7.5.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_04280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:60156"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.11" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1915"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043211">
        <property type="term" value="F:ABC-type carbohydrate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015862">
        <property type="entry name" value="ABC_transpr_MglA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF7">
        <property type="entry name" value="PTHR43790:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="252"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="499" mass="55360" checksum="E443D08A943D58A4" modified="2010-05-18" version="1">MSEYVLEMKEITKTFPGVKALDRVSLNVRPGTVHALMGENGAGKSTLMKCLFGIYSPDGGEILLDGTPVRINSAREAMDDGISMIHQELHPIRFRPVMENVWLGRFPSTFGVVDHKAMYDRTLALFKDLELDVDPAAQAGSLSAAKLQMMEIARAVSTNARIIIMDEPTSSLTDRETEHLFKIINRLRKQNIAIIYISHKMEEILQIADEVSIMRDGHYIGTWPASELTMDGIIQRMVGREMTDRFPPKLVAPSEELVLKVEHLSSPLKSSFQDISFELRRGEILGIGGLVGAQRTEFVEALFGLRDVASGTVLKDGEPSLSHSPREAKAHGLALLTEERRATGIFGILPVLENTVIANQKHYAHLGVLNDRERIEAASESCGELNVKTPSLDTLIQNLSGGNQQKVLIARWLLTNSDVLILDEPTRGIDVGAKYEIYTIMLSQIAQGKSIIMISSEMPELMGMSDRIMVMCAGRVTGMLNRDQFDQVEIMRLATQFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P3</accession>
    <name>D4M7P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases</fullName>
            <ecNumber evidence="2">4.1.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.17" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04430"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1928"/>
    <dbReference type="HOGENOM" id="CLU_006033_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-274-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="27"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="239" mass="25818" checksum="B2718D85D6AED698" modified="2010-05-18" version="1">MGRPVRYNLITGSRKGEIVTLLERERNAVVEYGRRLVERGLTRGTGGNVSVLSRERRLFAVSPSGMDYFETRPEDVVVLDMEGNVADGARRPSSEVEMHRLIYLEREDVGAVVHTHSVYATAVSCTREAQAGGLPPVHCAAALAGGDVRCTAYYPFGTRELAEAACEGMRGRFAVLLGNHGVLAAGSDVGHAFALAEQLEFACEVLVHAAAVGTPALLSSSDLLAARERFRDYGQGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q2</accession>
    <name>D4M7Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type metal ion transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_04580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1943"/>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-283-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="11"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="214" mass="23108" checksum="F6B796F0C93FDFEB" modified="2010-05-18" version="1">MKRLPEFWKAVGDTILMEVWAGSICFVVGLFLGVVLTVTRPGGILERPALYHVLDKLVNLFRSIPFIILLTALMPLSRLLTGTAIYVRGAIVPLVFGAAPFFTRQVESALAQMDKGLVEAALSMGSSPLEVIFRVYLRESVAPIARGTTITAISLLGLTAMAGAVGAGGLGDFAIRYGHDRNMTDITWVTVILLVAAVSVVQWLGERIARRSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q9</accession>
    <name>D4M7Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_04770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04770"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1970"/>
    <dbReference type="HOGENOM" id="CLU_024867_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-290-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="515" mass="54475" checksum="27CDC5582E84A461" modified="2010-05-18" version="1">MVLGTFAAAAAVSADVAAQAEAAGGVLDSILSSPFFTQLLDWVKDANGFLWGPQFLIPLLCGTGLFFSLRLGFVQVTKFGTACRKLFGDFSIFGEAAGKSGMSSFQALATAIAAQVGTGNLVGAMTALITGGPGAIFWMWIAAFFGMATNFAEACLAQLYKDKDESGQVVGGPAFYISRGLGGGVFARFLAAFFAVAIILALGFMGNMVQANSISDAFHGAFNVDVRVTGAVLAIVAGVIFIGGVKRIAAVMEKLVPLMAILYIVVGLALIAMNAHLIPRVFKDIFTCAFQAKAVWGGAVGVAVAKAARYGIARGLFSNEAGMGSTPHAHAVAKVNHPVEQGVLGIIAVFIDTFVVLNITVFSVMSAGLLEEGFFKDGEPIMKGISVVQAAFENHFLGAFGGPFIAICLLFFAFSTVIGWYYFGETNIRYLFGTKGLLPYQVLVMLFIFIGSVLKIDLVWELSDFFNGIMVVPNLIAILLLSGKVVRLLDEYNRGIPYDAERIKADLPTPGDAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V1</accession>
    <name>D4M7V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05380"/>
    <dbReference type="HOGENOM" id="CLU_731057_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-333-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="378" mass="43153" checksum="A3C14FD7E70CA90A" modified="2010-05-18" version="1">MTDFEEFWWNNITGPHSVVTKTSELLSTKFAVLLLVPGDLPWRHTMRSAIDAEFKRRSSMMDILIRPIDVKDEYLQDIAPGQFILRNYASESVKNEYRVGSGMSMQEYIKRNSVLKNTILWLKGFNNAEQVKDWVNFCSDYATGAVVDGLFILEVQDNMRLPAHSSIPKINFSEYVDSYNLLLFCSFLLDEQKELTAQWKSYIAAMVSNLCETDAEVAERMILETNFMNEEPLDVLSRIAKEPDFVRRGEGAQHAFALLRNRNNLTLKKRLWSAQVQVLFPVIELERVEIVRQWHAEIAAALAKHPEQRGYGNGSNEAIDDLCDIELGQLNHMIINHMLEIPAPEIRSRIALLRTCRNLLAHGECCSAAQTGKLLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W5</accession>
    <name>D4M7W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin-dependent carboxylase uncharacterized domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_05580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2051"/>
    <dbReference type="HOGENOM" id="CLU_028967_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-347-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="340" mass="36519" checksum="59EEBD8C0D5E927F" modified="2010-05-18" version="1">MIIENGGILTTVQDGGRFGYESFGVSSSGPMDRRSFEIANLLVGNDRSEACLEATVIGPSISFAENAVMVIVGADMSPVLNGAPVPNCRAFAVRPGDRLRLGAARIGCRAYLAFAGGVDVPLLMNSRSTMVGKGFGGYRGRRLRQGDEVRLLKDVSGLPNLAGRVAEPEPIPSGERALRVILGPQDDRFTEEGIATFLNSRYTIGADFDRQGYRLEGPKIRHVTDGNIISDGIVFGSVQVPTSGDPIVMMAEHQTVGGYAKIATVITVDLPVLGQCKAGDAVRFVRTSVEEAERLAEASRRELDALAARIGRGFERPARRSFKVTVDGRAYSVSIEREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X0</accession>
    <name>D4M7X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05640"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2057"/>
    <dbReference type="HOGENOM" id="CLU_1459306_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-352-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="185" mass="20091" checksum="D290ED5658726114" modified="2010-05-18" version="1">MAGAVSLGMTSREVRRFGDGPAFCRVTCAMRPMRCARRAFSLAEVLIVLTILAALSGSVLSVGAIWGRPTAAQEADRAMRWLYGVVARADLSGRPFGLGVDEDAQCLQVRWEKPRSVERLPARSGCTFQWLGVGSATVDSHYAPQWGTFSSAMTTLIRDAEGKRHFLILSGQGQIRTADHPPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y0</accession>
    <name>D4M7Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2075"/>
    <dbReference type="HOGENOM" id="CLU_023257_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-362-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="370" mass="39974" checksum="419346F9D879DDCC" modified="2010-05-18" version="1">MDGKNLKKIVELRHELHAHPELSMHEGWTKRRLMDFIGANTTLAVVDCGGWFYASRYREGTPAVAFRADMDALPIPETISLPHASQSPGVSHKCGHDGHSAALCGLALELEAMECPRSVYLIFQQAEETGQGGAAAAALLPERHVSEVYAFHNLSGYPEGSVILRNGLCQCASRGLTVRMTGRRSHASEPEKGNNPAFALAALVTEVRTLLARPHRGMVLATVVNLSVGRRDFGISPGEGTASMTLRADDEAEMEAFEAEVRGRAIALAAAEGLEVGFDVSDPFPATVSDAGCVARVEAAAGRLGCPVVWMEAPWRASEDFGHYTKRCPGAIFYVGNGANWPALHTPEYDFNDRILETAVDVFREVYRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M808</accession>
    <name>D4M808_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06270"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2113"/>
    <dbReference type="HOGENOM" id="CLU_1473148_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-390-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NBD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="183" mass="19470" checksum="B6E79C2B4348C382" modified="2010-05-18" version="1">MACGSVNPVTRRQTAAAEGCGFQHVHLSVRQKLDEAWPSENESSALIEDCLARARRYGRVILDTNDPEGSAETQERAAAMGLSLPQTRVRVSKALAELTKGLLDRGLEATLLCVGGDTLLALMQAVGTHELTPVCEMAPGVVLTSFVYGGRARYILAKSGGFGKPDLLCCLADRIGAGREEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>D4M823</accession>
    <name>D4M823_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alaS</name>
        <name evidence="13" type="ORF">SY1_06490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06490"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2136"/>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="4"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="879" mass="97687" checksum="BF462C1DC6C5D825" modified="2010-05-18" version="1">MQHRTGRELREMFLKFWEEKGSHRCPSFSLIPDDPSLLFTIAGMVPLKPYYLGIRQPPYPRIVTSQKCVRTNDIENVGRTARHHTFFEMLGNFSWGSYFKKEAITWAWEFLTDRIGLDPNRLYATIYQDDEESREVWHRQAGLPEDRILRFGQDNNYWFMGDTGPCGPCSEIYYDRGPDYGCGKPSCGVGCDCDRYLEIWNLVFTQFDRQKDGSLPNLPHKNIDTGMGLERLASVVQGVDTDYETDLFTPLIRHTCARAGIQYGQGGRNDMAVRVIADHVRSVAFMLADGVLPANDGPGYVLRRLLRRAVRFGRLLGFEGAFLCEYMPILIDLMGDPYRELIDQRPTIEQIITVEEERFQRTLQQGTDLFEAETARLAAAGRREVPGEVVFTLYDTYGFPPELTREMADEQGFAVDEAGFKAAMQQQRDRARASSKQKKSALAGDVYTELENEGGATRFTGYASAMGAGKVTAILTKEGRRDHVEGNGEFELVLDETPFYAERGGEVGDTGTIRDGETTLEVLNTVPHGGVIVHRVRMTEGSVRVGDSMTAEADDARRQAIRRNHTGTHLLHEALGRVLGRHVRQAGSLVTDRFLRFDFTHHTPLTDGQIEEVERIVNGEILRNVPVSTAEHTLEEARELGAKALFDEKYGDVVRVVTVPDFSMELCGGLHVRATGDIGSFKVLREESIGSGTRRILAMTGMEVVELMQVLFGLRRRLMGILSADEEGLEAKAKDLAEELRALQKRAQERARHELTDNVDRFVERRRVGGAVLHIGRFPDVKSDVLRDVGDRVKAGPDPSVALLASVDENGACTLIVMADDRAVKLGANAGAIVREASAVLGGKGGGRPSTAQGGGRDGEKLDEALERAAEVLKGQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M825</accession>
    <name>D4M825_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asparagine synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2140"/>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-407-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="299" mass="32094" checksum="A6D6524EB149EAB0" modified="2010-05-18" version="1">MEGADLESEVEERLRGVRRLLEAMGDVAVMLSGGVDSALLAALAHEALGRHAVAVTIESPLLSADERADAGRLAAQVGIRHKVLPMDELEDAGFVANPRDRCHLCKRMRLEAVVRWAAERGIPWVLDGANADDRGDYRPGMKALMEFGSVRSPLLEAGMTKAEVRAAARAMGLFTWNKPARACLASRIPYGEPVTAEALRRVEAAERFLAGILPPAAQFRVRAHGDLARVEAECRDLPRVLARREAVAEGLRAVGFRYVTLDLVGYRVGSLNEALDQGAAKDVQAPAGTAGAVGTKGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M827</accession>
    <name>D4M827_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolases, including glyoxylases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06540"/>
    <dbReference type="HOGENOM" id="CLU_061385_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-409-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="30"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="310" mass="34145" checksum="863F456CAF70E952" modified="2010-05-18" version="1">MTAAAGSPHDFGEGLFLIDLPQRMPGFRRFIASWFFVDALGRRVVVDPGPANTIPLLNGALERLTEDVDLVLLTHIHLDHAGGVGAFCRRWPRAAVLAHPRAFSHLRRPERLWSASVRTLGNVALAYGEPEPLTAPLLSEDPDGLIEVFPTPGHAPHHVALRTRPREGGPLLFIGEAAGLTLPSLDGALWLRPTTPPRFDAAAALSSLDHAAVALRGDERLCYAHWGLSEDPAGRLSLAREQTERWLELIGTMLDRRPEEVVECLLRRDPLLQARLDEDLMVRERHFMANSVQGFMGFLNEAGRGPAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M837</accession>
    <name>D4M837_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06710"/>
    <dbReference type="HOGENOM" id="CLU_982241_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-420-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061835" evidence="1">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="288" mass="31718" checksum="CAB5CC2C5EB883B8" modified="2010-05-18" version="1">MRGRPLVLAAALFLLSLPARAALADELPIAVTQPWIALIVSFLGGPNVAVKPLLIWNDAGDSIRAEGGRALRNLPTDARIVALDSADLTGAGLKVGAYGNLRTLYNPFPIPPERWDASLPDPSVMPFVAQRVLTVLADWDPQNYLYYQRRLAEFQARLSSSVLAGRQVLRDVRVCDLSGASSALLRAAGCRMERPDLHLLDSWSRASPKQLQEFLEERIAQGVVLVMDGGTPRNLRSFLGGRTEVFSFARPPLNQDYPAFLNEQYISLWQKITAKPPAGRRPDAPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M859</accession>
    <name>D4M859_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidases related to nicotinamidase</fullName>
            <ecNumber evidence="2">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07020"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2189"/>
    <dbReference type="HOGENOM" id="CLU_068979_13_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-442-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="186" mass="20103" checksum="A996A58626E1D2CB" modified="2010-05-18" version="1">MSKETLLVVDCQYDFIDGSLACCGAEDAVKNAVDYINAHPAVRVLYSADWHGKGHCSFKENGGQWPEHCVAGERGSAIHEAFTRDVARAGQRPGEENVYHKGTDDGREEYSAFEARNAAGRTVGQDAGECVVVCGIASEFCVRESALDLLRTGRRVTLLVDAVGYVNAEKHRENLADLEAQGATIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M869</accession>
    <name>D4M869_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07230"/>
    <dbReference type="HOGENOM" id="CLU_1473149_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-452-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="183" mass="20443" checksum="F2421DDE38EFB37E" modified="2010-05-18" version="1">MKDNKVTVLTLLFFLLCASLIGGVWFLDKRVRDLQEQYDEVEQRRVDLNGATGALMEQKKVFTEAFNELDNYHVNVASDDMNFYANVQQAVQDKGVEILSTRQQGVNAEGVGAISMTLRGDYYDMVQVLAAWRSLPMTVRVVNLTVRQNEPSRDSGNGKNAPLGRVEADVTVEAIVAANNSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M871</accession>
    <name>D4M871_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07300"/>
    <dbReference type="HOGENOM" id="CLU_3168417_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-454-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="47" mass="5018" checksum="F7529DE136D84D66" modified="2010-05-18" version="1">MLAVRKRIPAPRRRASMRAGTNTAKVFPTPVGASRARTAASASLRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4M886</accession>
    <name>D4M886_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tsf</name>
        <name evidence="9" type="ORF">SY1_07500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07500"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2238"/>
    <dbReference type="HOGENOM" id="CLU_047155_1_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="8">
        <location>
            <begin position="33"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="198" mass="22416" checksum="6E7FACA27518E1AA" modified="2010-05-18" version="1">MAEITAAIVKELRERTGSGMMDCKKALAESGGDMEKAIDYLREKGLAKAAKKADRAASDGRVFQYIHTNFKVGALLELNSETDFVAKTDEFNHLGHEICMQIAAANPQYVRPEDVPEDVLQREREIYRQQLIEEGKPAQAIDKILEGKVRKFYETSCLLEQEYIRDSNKKIKDLVTDMIAKLGENIVVKRFARFSIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M897</accession>
    <name>D4M897_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted permease, DMT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_07700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07700"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2261"/>
    <dbReference type="HOGENOM" id="CLU_033863_21_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-482-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="159"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="313" mass="33383" checksum="7EC9F4FB094C9689" modified="2010-05-18" version="1">MRTLTSFVAGPRGIRWTQQRADAALGLVAMAWGSSYLLMKMGLEGIPPLSMIALRFGIAFLTVALIFARQLRRTTSRTLRHGAILGLFLFGLFAFLMYGLRTTSASAAGFLTSATVVFVPLLQAIFRRKAPDAATVVGTAAVMSGIGLLTLRDAMTLQWGELLCLGGALLYACQILLTDIFTHQEDGLLLGVWQLAFAALLGFVASLLLEVPAWPANAAQWAAVLGLALLCSAFGFVLQPVAQRYTTPEHAGLLFAMEPVFSALLAFLFLRETLDARGYAGAALILLSVLFVARGKPAPKGAAAGQGEDVRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A0</accession>
    <name>D4M8A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_07760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07760"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2268"/>
    <dbReference type="HOGENOM" id="CLU_825750_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-485-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="336" mass="37106" checksum="69188471C67DA6AC" modified="2010-05-18" version="1">MRMQSKRSPIEVQNAIDRRKLWLAYLVFPLISLLPVLIPLVMPGMKEQLTSQLVLQLILDMCLYVLFRGVLFPTVIRFLLLRRGTRYGVETYAFTVLSIVISILACWLVYEEPYFPLVFDFFSAYNILTYRSSGKNAISTGRLLALTGLTIALLAGWCVVLDDEDETLNRKVVQAVASIGALCYTFSSYRNVKGATRGATRGAAPSPSPSPSPSGPAAAPIRGQALLPPWETGAAEPQVQAQPQAQVQPQPTNVFSASSGLETLQDLTDEEAFSCLGIARSATMDEVQRAYERRKELLNPASFVMGSVEYQDAVRTLQLLDRAYHKASMACMARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B3</accession>
    <name>D4M8B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidase, hydantoinase/carbamoylase family</fullName>
            <ecNumber evidence="5">3.5.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_07900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07900"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2282"/>
    <dbReference type="HOGENOM" id="CLU_024588_6_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-501-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050538">
        <property type="term" value="F:N-carbamoyl-L-amino-acid hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="4">
        <location>
            <begin position="213"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="406" mass="44096" checksum="81AC891D1D7F8808" modified="2010-05-18" version="1">MQHSVSEIRYCGELFEAFYDVGSTREGGVTRLGYSAVEDEMHRRFEALARELGCGVFTDEVGNTFASNGEEGDYYLLGSHLDSVVDGGRYDGVAGVIAGLMVVRRLQEEEEVRLPLRVAAFRCEESSNFGLCTIGSGLIAGQEKYSSDIGSLRSRDGERLDEIFQKRGLSFSPKNISGIKEYLELHIEQGKVLEETGTEIGIVSTIAGPRRFRFILRGMAEHSGATPMGLRNDALCAAAEVILAVERIGREEAVHQSVATVGVVENRPNVLNVIPGEVALGIDLRGIEEESLDRMEQALRSRAQDIAKSRGATCLEMKIGSVPPVAMSRRVQRGLERAASRLKISSRNMPSGAGHDAMSFAALCDTGMVFIPCRHGVSHNRKEFASLSSICDGAAVICEYLKGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C5</accession>
    <name>D4M8C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_08040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08040"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2297"/>
    <dbReference type="HOGENOM" id="CLU_626686_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-514-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="411" mass="45012" checksum="303829FC27C42643" modified="2010-05-18" version="1">MEEKHGVERGGPEGHRRRVGVEAHGIRLPVIQRGDDLVRIVAESLIEAARSPYAPFALRDRDVVAVTESLLARAQGNVVSLDDIALDVAGKLDSDEVAVAFPILSRNRFFPLFKALTKAIRGRVHLFLSCPADEVGNHLVDPMEYLKRASGLPECFGLDEFRRRFGEYRHPFTGVDYVELYRGVAPDRIEVHFTNNPLNVLKATKCVIMANIHQRGTYAALLREQGASVLTLDQICNAPLRDGGGYNAEFGLLGSNFSREGSVKLFPRDAERFALDLQQEVLRRSGRRVEAMVYGDGAFKDPACGIWELADPVVSPGFTEGLRGTPSEIKFKMVADNASGDAEAAVREAIRSKPASDGKESGLAESRNALGTTPRRYTDLLGSLCDLVSGSGDRGTPVVHVSGYFDSWNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8F0</accession>
    <name>D4M8F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar P-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Basal body P-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flgI</name>
        <name evidence="5" type="ORF">SY1_08480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FlgI family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.45"/>
    <dbReference type="HOGENOM" id="CLU_045235_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009428">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, P ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00416">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001782">
        <property type="entry name" value="Flag_FlgI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30381">
        <property type="entry name" value="PTHR30381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02119">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01010">
        <property type="entry name" value="FLGPRINGFLGI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009009544" description="Flagellar P-ring protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="380" mass="39712" checksum="40E6D3E173E215E1" modified="2010-05-18" version="1" precursor="true">MKCFRALGFVLACLLVGLQTAGATASVNLQDMDFTKLHPRVRIKDIADIEGARDNQLTGVGLVTGLRGTGDNSAMTTHMMRNMMRNFGVTLAPNEVKTRNVAVVSLTATLPPYARPGQRIDVSVNAIGNAQSLQGGTLIQAPLHAADGNVYAVAQGSVLVGGWAADGSSASTTKNVPTVGRVPSGAIVERDVPSDFTLGGQMALLLRDPDFTTAQRVADAINQKFGAIASPVDAGRVAVNLPGQYLAAPTAFLANVERLEITPDMVARVAVNERTGTVVMGGNVRISSVAVAHGNLTVSVKDDPNVVQPEAFSGGETRVEIRTDITVNEDGASMIAMPATTTVRDMVRVLNAIGATPRDIITILQAIDKAGALHGQLVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G1</accession>
    <name>D4M8G1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">SY1_08670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08670"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.63"/>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="148" mass="15550" checksum="23DB0515AF170C0B" modified="2010-05-18" version="1">MNLHDLRPAPNSRTKAKRLGQGIGSGTGKTSGKGNKGHKARTGGGVRPGFEGGQMPLVRRTPKRGFNNARFARTYQIVNVGSIEDKFEAGQEVTPDTLMRAGLISGASLPVKVLAKGDLLKALTVRANAFSKGAEEKIKAVGGKAEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H6</accession>
    <name>D4M8H6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ORF">SY1_08850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.84"/>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="207" mass="22526" checksum="145A909D410AD911" modified="2010-05-18" version="1">MPTIKVVDFSGQSAGEMELSEVVFGAPIHVAAMHQVVVAHLANCRQGTHAVKTRGDVSGGGKKPWRQKHTGRARQGSTRSPLWVHGGVAHGPKMRDYSQKVNKKVRRLALLSALSVKVRDAQMLVVRGMEMEAPSTKTMKGFMDAIGAEKALVIYSGNGENVARSVRNIPGARYLNVASINVYDLLNSRTLVVTPEVVARLEEVYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8L1</accession>
    <name>D4M8L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_09530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.155"/>
    <dbReference type="HOGENOM" id="CLU_004785_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-605-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="562"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="731"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="835"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1067" mass="119230" checksum="8EBB6F4955B37316" modified="2010-05-18" version="1">MRPLTLTMRAFGSYNKETTVDFTRPNQKLFLITGDTGAGKTTIFDAIVFALYGETSASGRSGGRRQGEDLQSQFADLDTEPFVKLTFSEVHGGEKRHYTVTRTPRCHQSLKQKAGSRPKGETVSLSMPDGLVYTGNLRETNQKIGEIVGLTKEQFMQVAMIAQGEFMELLCAGADKKKDIFRKLFRTRLYQDVVDELKRRLDDAAKRVTEIRSAFQAEAGHVVIPEELDGMERLKEIRSRLLTSEGGTVMDMEALLAELSALCSRLKEGAALAASERYEAGRRRDEARDAYTGAQDLARAFEELERSERALAECEAEEGRIQEAGRLMIQINAACEIQPLHQRMGDAEKAAAETERKLADLKGSLPDLNLDRQRAEASEAEARSVQAAGIEEFTRVSERVSRALQVLERIRATTERFEEWRAALSAAEMTSLQAKDALMNFEAREAAWRAREKELEGADLRLAHWEVRRREAEDLMVEVSLAEDAGRDAQRQRAETERLQGEYASVREEYNRKRDEYVRRQEEFLDAQAGFIAWEKLRPGEPCPVCGSLDHPRPCLLPEGSRDLTREVVDALAEEVASLQQDLTKRSTASGSALSLLEEKERTLKGALARLQERLARSVPEASEAPSLDQVRALLESWRAGIRAEGVALQEGAQALSRIKESLKSVDEQRQALTIAVDQAVRTAHQAESALAAAEAELRGLEGQRDYATVADAQSALDEARVAKRKADSTFEAAREAAQAARSSLENAEAAIARFAEELPLQREEAERRRQAYEALMDEKKLSEADWMETVRRYGREDVGELLDEVEAHRKKKAAAEGARDAALKAVNGREKPVMEDLERARDKAEEELEKARAAWARLDRAFEADDAALCALSPRMEERKQVAREHARLNGLHRGLGGRESGARMDIETFVQRHYLQRILHAANTRFQDMTAGQFELRLVQEDQAGEGRNQGLDLVVYSSVTGRERRVWTLSGGESFVAALSLALGMADLIQESASSISLDMIFIDEGFGSLDDRTRNQAVRVLQRIAGSRLIGIISHVTELKQEIEDQLIVSKDSEGSRVRWQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8L3</accession>
    <name>D4M8L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09550"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.157"/>
    <dbReference type="HOGENOM" id="CLU_1382359_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-607-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061536" evidence="1">
        <location>
            <begin position="29"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="197" mass="22012" checksum="2DC407306989280A" modified="2010-05-18" version="1">MRSSLLQKCLLSMAALSCLVLSASRGVAAEHWTEVFFNRCLALEKQAISLAERTIRDDKPSAEPSRYCPLEEKDIDDLWFLEWKKNGTTVSGASQQKGGKYHPYGIEIRDPDIVFPGGIRVGAGTEVLESYFKGCLNRSDYPEDFDSEYLEYENELPPSGTASIGYLEQNSAFLIECKGGRITSIAYGVPVDMMRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q9</accession>
    <name>D4M8Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_10360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10360"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.246"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-660-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="236" mass="25498" checksum="980B713029B74AFE" modified="2010-05-18" version="1">MPMLEVRDLQVSYGAIQAVQGVSFEMDKGEIVALIGSNGAGKSTILRTISGLEHAKNGSIVFQGAELTKMKPHKIVELGISHVPEGRRVFPRMTVTENLLMGATLATDKQAVRDDLERVFCIFPRLKERAGQEAGTLSGGEQQMLALGRALMTNGTLLMLDEPSMGLAPIVVEDIFRVIKQINENGASILLIEQNAFLALTTASRAYVLETGTITMQGAAKDLLTDERVRAAYLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R2</accession>
    <name>D4M8R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport systems, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_10400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10400"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.250"/>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-663-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061539" evidence="1">
        <location>
            <begin position="23"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="29"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="383" mass="40943" checksum="0CDF623374497945" modified="2010-05-18" version="1">MKKFLVLIMTLAALLQMTGALSAAEDLEKIKIGFAFPMSGSAAMAGRYSSHGAQVIEKELNGKITVQGKEYDIEFVYMDTEGAEEKTVNVYQRLIEGEEVIAIVGPDSSKCALAAGPVAQNAGCSNIPTFATNTAVTEVGDYIFRACFIDPFQGKIAATYCWNAGYKTACIMFNNADAYPVGLKDAFIENFEALGGRVLAIEEYSGSDVKDYNVQLTKLAAQNADCLLLPNLNVELGLEIRQARTAGITCPIVCGDSADTPEVAQVAGSASEGVAYVSAFSAESTAPAAAEFVKKYTAMFPQELPNSNAELTYEATQMVLYALENVREISREGVRDALASLKGLEQPSGIMNMGEDRNPVKGAVIMQYDSKGVSHFVSAVNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T3</accession>
    <name>D4M8T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10800"/>
    <dbReference type="HOGENOM" id="CLU_2553341_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-684-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="82" mass="9041" checksum="2A3034FC78D246D6" modified="2010-05-18" version="1">MLLPKDFVSTMSDEDKDKIMDEADALDERGEKEAANCLRNTIPMNPILADGMKKVGGIQKLKDLGFNLNDAVKLFGEGWLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U3</accession>
    <name>D4M8U3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="7">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rnf electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnfE</name>
        <name evidence="8" type="ORF">SY1_10960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10960"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.306"/>
    <dbReference type="HOGENOM" id="CLU_046659_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-694-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30586:SF0">
        <property type="entry name" value="PTHR30586:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="233" mass="24161" checksum="3A020F28A7E8E8C6" modified="2010-05-18" version="1">MSRNPISIIKNGILTENPTFVQCIGLCPTIAVTSSVENGIGMGLAATFVLIASNAVISMLRKLVPDEIRIPIFIVVIAAFVTVIQFLMEGYAPALNRALGIFIPLIVVNCIILARAEAFASRNGVIASIFDGLGMGLGFTAALTVLGAVREVLGAGTILGLPVVPAGYQPALLVILAPGGFLMLGIFMALFRAVQARLAARRGEPAPEAPAGCAACAMSGSCPGARIEKEDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X2</accession>
    <name>D4M8X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11410"/>
    <dbReference type="HOGENOM" id="CLU_141583_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-723-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="1">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="141" mass="15172" checksum="A5C2FFF4B4AD1C6C" modified="2010-05-18" version="1">MADEIKVYKCRGIVKGKAAGEAIVSRDAMCFYLTDPITGNVIERNHAIQGKCIANKILALKSGKGSSVVQVDGFYQLWGKHNLPSAIIIKETEPVIVSAAVMVGCTMVDRLEADPFSVIQDGDYVEVDADAGEVRVQKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y2</accession>
    <name>D4M8Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Entner-Doudoroff aldolase</fullName>
            <ecNumber evidence="2">4.1.2.14</ecNumber>
            <ecNumber evidence="2">4.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="2"/>
    <dbReference type="EC" id="4.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11560"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.392"/>
    <dbReference type="HOGENOM" id="CLU_075245_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-733-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="320" mass="34248" checksum="89A5BA20EF7CF8EF" modified="2010-05-18" version="1">MNEVLQRIADVGVIPVVTVDNPNHALPLGTALLEGDLPVAEVTFRTNAAEESIRVLASELPDLLVGAGTVLTVEQARKAVSAGAKFITSAGFNPDLVGYCMDNGILVVPGANTPTQVEQGLRAGLSLMRFFPAEQSGGPAMLRALSAPYHAMHYIPSGGVNAANLQGYLALPCVLAAAGSWMAPPDLIAAERFDDVARLSRQAVIQAVGFELDHVGINEPDAGTAQDESELMCDLFGFPLRQGNKSFFVGDGFEFMKTPFLGMHGHIALSVLSMTRALAFLARKGMGTRSETERHDERGRLTFVYLDREIGGFAIHLMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M904</accession>
    <name>D4M904_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type amino acid transport/signal transduction systems, periplasmic component/domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11910"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-757-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="272" mass="31331" checksum="A51CFF70531F4A90" modified="2010-05-18" version="1">MKRFWGWGLILAWAFIACVSREGIASEDKVIRVATPGNYAPFTMYDEATQEWSGFEIDMWRTIGEKAGYEVQWVRLDLPANFAEMDLGRVDTVAKQISITPSRQQKYDFTQPYFFSPYCLTVREDNNEVKSWKDMEGKSIALREGGSELEFVAVLDPENKVEKSIYESNMLQDVSLGRVTATPYPFLTLPWVLKKNPELKLKAVDLENPIFTEVNAYPFARTDRGRALLKLTDDILTQMIEDGSYAKLCEKWFGTNVMDSKYAKEYREKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M917</accession>
    <name>D4M917_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12060"/>
    <dbReference type="HOGENOM" id="CLU_128138_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-770-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061753" evidence="1">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="156" mass="16985" checksum="AA1DF57081F5BC56" modified="2010-05-18" version="1">MTRLVPWGAALLCALFLLAFPGPGAAPGGAEDVFLPVTSHPLMAVFRKSLPDREVLLTTPGDCNADGIEDLVVVYREDRDKNHMVAVYSDGGAFRLSAPVRAPLENCRLQWRDIDEVPPVELLVSGQKGIYIGYAVFRFVDGEWISLFGDGMDGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M925</accession>
    <name>D4M925_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12140"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.450"/>
    <dbReference type="HOGENOM" id="CLU_2023347_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-778-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="122" mass="13905" checksum="54E3DB80441EDFD9" modified="2010-05-18" version="1">MKIRMDFVTNSSSSSFIVARQGELNEKQKEAIIKFVEEKMLGKKVLGPESGEKDIQDFFEDNYVVDEDGIREALKEGKDIYSGTLDLETAEVYYTRLFQDLWAVLDQTGDGNFVAIDDDLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M927</accession>
    <name>D4M927_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12170"/>
    <dbReference type="HOGENOM" id="CLU_1945576_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-780-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="139" mass="15666" checksum="8EC0C2AF04DB64A7" modified="2010-05-18" version="1">MEDAEQERDGELTAPLNRLDYWMMYLSGMAAEEMPEEVAKDEMISQALDLEKQFLQNQEERQRYITSYKAMVDDLMTDETIRRVARDEGLVEGEAKGKVEGIAATARRMLNRGVSPEQVADFTGLSRGEVEALRAGTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M933</accession>
    <name>D4M933_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12240"/>
    <dbReference type="HOGENOM" id="CLU_031290_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-786-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030821">
        <property type="entry name" value="Synergist_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04564">
        <property type="entry name" value="Synergist_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061848" evidence="1">
        <location>
            <begin position="30"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="451" mass="48593" checksum="CE5E8C8FE620C0AE" modified="2010-05-18" version="1">MYRKTMKRWFSGMLLVTAVLVLSAMPVAAANLLFTAQDDLFNNARLGKISGYRVYTLSRDIGGKYGQGIFPFKNANQERVAVTLCQTFDGVQPDVIQVYDPRFISTLPVLTGHPYLPNIRSMVSKGSYLYGTSYMGKANAQNTKARVARIGMSGSTYTPDMDHVYEYNPPSGDGHGEALVSYGNFLYALFTSQTGSYPNFVYNPSRLVKLNAELGQVRAIDLYGKNTDGGTLGATCLSGGTLYIAAWGGSQPTAPNYNPDSMIESVNLNNLSHTTCVTGSQVAGRETGWRHHFTSIVIVGSTAYVQAVSWNASWIGGEVRLYAVPVASLGSLGRAHRVDTVSFSGGWRLGMVQDGQYLWMAAGKNLRRYTLPANGTANMVFGPNGVSLGGNISSFMPIPSLRSVFAAQTAQEEPVQAMAAKDEKDGGSGCDAGFGWLLLLAVVPVALRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M934</accession>
    <name>D4M934_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane receptor for ferrienterochelin and colicins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_12250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.466"/>
    <dbReference type="HOGENOM" id="CLU_342850_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-787-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="54"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="270"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="661" mass="73995" checksum="ED5DB415FD1F6721" modified="2010-05-18" version="1">MKVGPPSPAFVLLLFALTPVFVLGAVGPALGTTELPEERVVAPPVEDEDKLLLSPGSVTVVRPQEMKGEQKNLPELLKQVPGLHVVETKGRGAYTVASIRGSSAAQVAVYVDGVLMNLGSEAAVDLSTIPVENVERIEVYRGYIPSRFGGASMGGVINIVTKKPEKSGGTLSLGAGSWGRARAGLAWDAPLGGGSLFLGLNHDRTDGDFRYPNDNNTPYTPTDDYEADRENNRYANTDVLLKWNDDHWRVEGGWKRNDRALPYPAPGADKPESPRGADFRVDQWNVVLARRQTWGDLEWGFRAEYLGQSKRYDDPADTIGGWGEQHNRYDTDRLSFALDGALPVGDHHLLEFLWNYYDETLNTDGDVVKKMRGFREHNRYSWNAQVQDTIGLGRGDDLWLTPVVRWNAADGRTEFSWGAALDWRMSREWTLKLTGGTYNRAPNLYELYGDGAFVIPNPSLRWESGTQWDVGLAWKGQLWGGEATAELTAFGRHSDDLIDYLMTNPRFAQYVNIGKARVIGTELEVSAEWAKWALYLAATWMDPKNETPGYMDGDPLANRPEWEGLLRATRKWERSSAFAELRYVGRNYYDMQGEVGWTDLLTAGLGVRWQPKENLKLVLGVDDLFDKGPDLKLFAVGTGPERMLWYPLQGRTFYVSLIWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M944</accession>
    <name>D4M944_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide chain release factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_12460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12460"/>
    <dbReference type="HOGENOM" id="CLU_036856_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-797-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="4">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="224" mass="25544" checksum="454FEF93F3EEEBF1" modified="2010-05-18" version="1">MLLRMYLRYAERDGLKATVLEATNDEEAGIKSATVMMEGDNAYGFLKAERGVHRLVRISPFDSAHRRHTSFASVLVTPEFSDDVDVDIRPEDLKVDTYRASGAGGQYVNRTDSAIRITHLPTGIVVTCQNERSQHMNRQVAMHVLRSKLYERALQERQDELASVVGDKKETTWGSQIRSYVLHPYTLVKDHRTGLEKGNAQAVLDGDIDDFIMEYLRFRARREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M949</accession>
    <name>D4M949_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate:ferredoxin (Flavodoxin) oxidoreductase, homodimeric</fullName>
            <ecNumber evidence="14">1.2.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SY1_12610</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.-" evidence="14"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.496"/>
    <dbReference type="HOGENOM" id="CLU_002569_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-802-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="687"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="745"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="987"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="757"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="764"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="822"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1096"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
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        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBL28394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1201" mass="131198" checksum="7C64C9D1AEA0DAB5" modified="2010-05-18" version="1">MKRNWKTMDGNEAVAHVAYAFSEMATIYPITPSSPMPEHIDEWAAHGRKNIFGKTVKVTEMQSEGGAAGAIHGALSAGALASTFTASQGLLLMLPNMFKIAGELLPGVFHVSARALATHALSIFGDHSDVMTCRMTGFTMLAAGSVQEAADLAAVAHLTAIETSVPVLNFFDGFRTSHEIQKIDVYDYADLAKLVDYDAIEAFRERAMRPENPFVKGTAQNPDIFFQAKEASQPYFDRVPDVVAEYMRQVSKLHGREYYPFQYYGAPDAERVVVAIGSVCQATEEVVDWMNARGEKVGLIEVHLYRPFSPKYFFRALPSTVKAIAVLDRCKETGALGGPLYEDVRSMFFDYGPNAPKVVGGRYGLGSKDTTPSCIKTVFDNLKLYEPRNDFTIGIVDDVNDSSLPMQDHIDTAAEGTVCCKFWGLGSDGTVGANKNSIKIIGDHTDMYAQGYFDYDSKKSGGITVSHLRFGKSPIKSTYLIDSADFIACHKQEYVNQYDLTAGLKKGGTFLLNTQWTTPEALEEHLPSDLKRKLANLGAKFYVINAVDEAQKIGLGNRTNSIMQAAFFKLANVIPIDDAVQYMKQAIVDTYGRKGEKVVKMNHDAVDAGLKSLIEIKIPEGWSAAPDQVVQKRGVPDEIPEFVTGQCQVINAQKGNDLPASAFTGEYVDGRFPSGTAAYEKRGVAVNVPEWNGEKCIQCNQCSMVCPHAAIRPFLLDAAEQEAAPKDFGAVDPKAKALKEAGYRYKIQVDTLDCLGCGNCADICPVKALEMKPTASQEGEIDNWTYAVEGVADKDKVVDKFTVQGSQFQRPLLEFSGACAGCGETPYAKLITQLFGDRMIIANATGCSSIWGGSAPNMPYTVNAEGRGPAWANSLFEDNAEYGYGMKLSVNVKTNYLVEAVTSLIKMECVPEEYKKVLQEWLDTHLDGEKSKASAAKVEELLDEVFCCCGGHEHEHADLGDEAMAEFSKIAEYHDYLVKKSVWIFGGDGWGYDIGYGGLDHVLGSGEDINVLVLDTEVYSNTGGQASKSTPTAAIAQFAASGKRVRKKDLGRMAMTYGHVYVAQVAMGADKNQLLKALKEAEAHKGPSLIIAYAPCINHGIKAGMGKTQAQSKNAVEAGYWHLYRCNPSLAAEGKNPFILDSKAPTKDYKEFLMSEVRYASLKLGFPDIADKLFEQAAQEARERYETYKAMAEMGPVPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M950</accession>
    <name>D4M950_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12620"/>
    <dbReference type="HOGENOM" id="CLU_083811_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-803-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061849" evidence="1">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="262" mass="29908" checksum="10FB6935B7F77387" modified="2010-05-18" version="1">MRASFKSWLCALALLCFAWEGAAAASDFEFRGGIEPKDPTSRLLAFYVNRFTPEELTLTIDGEPDASGRYRDLYMDLTGVMIEGVRLDKLTFRMLDVQFNAPENWASGDVECRSALRIYAYGRILQDDINRSLEARTFGEDDHWRHVAMTIAPEGLKGRGYYMAKVLFVTLDILIEIDSGLKIVGNKELWLKDPQVKINRLDLPDYITNQALSQIQPLLDLNRFPLPMSLHKVELEEGRAILSTRVLPEPMERGVTYHYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M970</accession>
    <name>D4M970_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_12990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.529"/>
    <dbReference type="HOGENOM" id="CLU_045647_5_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-824-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="213" mass="22823" checksum="8036107207419398" modified="2010-05-18" version="1">MSRSLPGRQPEAGEGLSVLAAQIEAVLFLASSPVSEAELRGVFEVSGAELARAIEELGEHLKSGHGLVLKAMAGGWVLGTNPHFAEVLSRFRDTAQRGRVRLSRAAVETAAIIAYNQPVTRSEVEELRGGFRSERVIETLLGHELIRIAGRKKASGSPLLYRTTPRFLEVFGLEAIADLPSLEELGELGAGPLDDDGRGGEDDVRDGGERDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M971</accession>
    <name>D4M971_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_13000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.530"/>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-825-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="244" mass="27243" checksum="A6BCFF3D6846F027" modified="2010-05-18" version="1">MEVRGTRLNAFLAACGVASRRRAEEVIRAGRVRVGDRIVLAPFFQVDPEVDEVTCDGRTLKATEPVYVVMNKPGGVVCAVSDKYDPVVVDLLPEAVKSRRVYPAGRLDRESEGLLILTNDGALTQEVMHPSKGLHKEYEALLNVPINERQLARWRGGFEIEGRRAVPISVTLMDREPEGRWVSVVIGEGLKREVRVMANLAGFSVERLVRRRLGKMVLEKLRPGEFVDLSFSELYTKIFEGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>D4M992</accession>
    <name>D4M992_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="13">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">metG</name>
        <name evidence="17" type="ORF">SY1_13370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SGP1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="13"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.573"/>
    <dbReference type="HOGENOM" id="CLU_009710_9_4_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 13 14" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="545"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="13">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="13">
        <location>
            <begin position="300"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBL28437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="650" mass="73790" checksum="FA3285F4E2625ECA" modified="2010-05-18" version="1">MDGMDERIFYITTPIYYVNDVPHIGHAYTTIACDAMSRYKRMKGCDVRFLTGTDEHGQKVQAAAEKRGVAPQDLVDRIHLNFKELWRVLNVSNDDFIRTTEPRHVRVVQDMFKRLMDQGDIYKGEYEGKYCVPCEAYVPESSMGPGGTCPDCGRPLTVMKEESYFFRGSRYVPQLIEHYEKHLKGVMPRIRYNEIMSFLKGEVRDQSVSRTTLKWGIPVPGDEKHVIYVWFDALINYASAIGYLDDRSTFDRYWPHVRHVVGKDIIRFHCVIWPLMLLALGLPLPVSIVAHGWWTVDGEKMSKSRGNVVDPCRVVEEYGLDPFRYFLLREIPFGHDGDFSEAALVGRINSDLANDLGNLLNRTLKMIQDYREGTVPAESLREMPEARDLQCQAQAALEGTDEAMEDFSFDEALKRIWSFIGRANKFIDETMPWRLAKEGSGDALDSVLLNLYEALRLSALMVAPFMPETAQRIWGQLGLEGDPLKCLYDDFRWGAAAGTRVGRAEVLFPRIDVREWKKAHGEKAVTAKEDKAMAEERRDEISIDDFRRVEMRVAQVVKAEEIPKSRKLYKLEVDLGYERRTVCSGIKAFFTPEELVGKRVILVTNLKPAKLCGIDSNGMILAASVKVGGESEALTLVAPEGDIPLGSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M996</accession>
    <name>D4M996_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">K+ transport systems, NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_13450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13450"/>
    <dbReference type="HOGENOM" id="CLU_784715_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-852-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="126"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="353" mass="39083" checksum="E3F9F56BEE3D35FF" modified="2010-05-18" version="1">MSVRFTKTVKNAKRGIALSRKFKHRFLGAAAILLLLLTLATLLVWWQEDGLKGSFWGAFWSVLFTLIGQGEFASHPQTFVGRIIVFFLSIFGVALFGVVFAEVMQRLINSRLKEMLGMSTCKFQGHAVICGWNTRGPYLVRQLMASGSEIAVVAEERPTGLHADVFFVQGNPSDRDSLLKAGVERARAAVILWDPKFGDDDSRAILTGLAVESSAPEIYSVMELHNPENERYARYAHVDDILYTDSLIADITGICTHFEGISSFIKDILSTSDDGHSFASFDVPPEFEGRTMEELFAHFRAQGTLPVGVIVPPAEDREALVSQWISHVDPPLDGIVSLPMKAVCIRRNAHGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C0</accession>
    <name>D4M9C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TrpR-related protein YerC/YecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13820"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.619"/>
    <dbReference type="HOGENOM" id="CLU_147939_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-876-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000831">
        <property type="entry name" value="Trp_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038116">
        <property type="entry name" value="TrpR-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013368">
        <property type="entry name" value="YecD_YerC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40080">
        <property type="entry name" value="PTHR40080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01371">
        <property type="entry name" value="Trp_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012508">
        <property type="entry name" value="YerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02531">
        <property type="entry name" value="yecD_yerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="95" mass="10695" checksum="39A566B33A8D5036" modified="2010-05-18" version="1">MSGNWKDTLTDQLCDAFLTLKTQEEVYDFLEDVATISELKALSQRLEVARLLKESKTYPQIAQQTGASTATISRVKKCLDYGTGGYNVVLERMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D1</accession>
    <name>D4M9D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent hydrolases, including glyoxylases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_14070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14070"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.639"/>
    <dbReference type="HOGENOM" id="CLU_030571_5_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-887-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="12"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="211" mass="23223" checksum="4F061329514B3BEB" modified="2010-05-18" version="1">MQYKRFPLGALWTNGYLFWDEDGEAFFIDPGGDASEVLKFVKVHGLKLRKVLLTHGHLDHIAGVRDLVPLVGSEVYVGRGDARILRNPPESLQTALRIHCDPITDFQEVVEGQTLRVGKIEVQVMETPGHTEGGVCYLIAEGDEKVLTSGDTLFAHSVGRTDLDGGDEAKLNASLLRLAKLPDDLRVLPGHGPETNIGKERAHNPFWPVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D9</accession>
    <name>D4M9D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_14340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14340"/>
    <dbReference type="HOGENOM" id="CLU_2990156_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-895-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025906">
        <property type="entry name" value="YjfB_motility"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14070">
        <property type="entry name" value="YjfB_motility"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="57" mass="6109" checksum="4B68DE7C7DD7CC83" modified="2010-05-18" version="1">MVDITADVARYSMEMASARTAQAVQTSMLKNVMEAQKDMMAQLLKSMGLGGALDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F8</accession>
    <name>D4M9F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14680"/>
    <dbReference type="HOGENOM" id="CLU_179920_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-914-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="101" mass="11583" checksum="A187C7CC7ACF3AB5" modified="2010-05-18" version="1">MAMPPLRRIALIAFLGLLALIMVTHYAFEVSRIEQIRSAIDEREDLLQRKKENVRNYEEKVSFYKTREGIEHLAREQYNLVASGERVILLASPGARSGDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G9</accession>
    <name>D4M9G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SY1_14860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.745"/>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-925-MON"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBL28514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="349" mass="36346" checksum="119AACFBF8456F8A" modified="2010-05-18" version="1">MGVLKRYGELLPITPSTPQVNLEEGSTPLIPLPRIGDRLGVKLYGKFEGCNPSGSFKDRGMVLAVAKALEEGRRALICASTGNTSASAAAYAASVGIPCYVLLPAGKVAMGKLAQALMYGATVIAVRGNFDRALELARRGAEESGCAMVNSVNPYRLIGQRSGAWEVCEALGGRAPDWHAIPVGNAGNISAYWAGYSEYHKLGKIPRLPRMMGFQAEGAAPLVTGKPCPEPETVATAIRIGNPVSAHLARAAVQESGGEFNAVSDEEILSAQRLLASEGGVFAEPASCAPLAGLVKLKGQGRLPEGITVTMVLTGNGLKDPDTAMGQVGRPIEIGDSPEELLKVLAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I1</accession>
    <name>D4M9I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine protease inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_15040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15040"/>
    <dbReference type="HOGENOM" id="CLU_023330_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-938-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="PTHR11461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="SSF56574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061033" evidence="2">
        <location>
            <begin position="34"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="SERPIN" evidence="3">
        <location>
            <begin position="52"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="420" mass="46155" checksum="70D3994A75765EBF" modified="2010-05-18" version="1">MLQFAMYFFGAAKVAAFCLFSLACLTAAENAAAAGTGEAEKTPPTLPAVRAVDGFALRAAAEFRKSNGDFFFSPYSILSVLGMAYEGSAGVTREAMAKALSLDDGFHASLGALSTGLRERMDGQDDQPVLNDANRVWLMKGLAPRSGFGDVLSRDYGGAAEELDFKDAPEEARQRINGWVSDRTKGRITDLILDVPKETRMILTNAVYFKGRWLQPFSAELTVPEPFHVTEAESKDVPMMKEDRESLYADVEGVKLLKLSYGGSASMLLALPKQGAMDELLKDLAHRDGLDLIRRWQASMTRHQVDVWLPKFKMEERYELKELLTTLGMGQAFSDAADFSAMTEDKEPICIDSVVHKTFLEVDEEGAEAAAATGMTMVYATALPPQDPPRAEFHADRPFLFFILDDTTGAILFMGTQSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L2</accession>
    <name>D4M9L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ethanolamine utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_15550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15550"/>
    <dbReference type="HOGENOM" id="CLU_143326_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-969-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009307">
        <property type="entry name" value="EutS/PduU/CutR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40449">
        <property type="entry name" value="PTHR40449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012296">
        <property type="entry name" value="EutS_PduU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="3">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="128" mass="13574" checksum="9F58C9498D6696F3" modified="2010-05-18" version="1">MPDSPFQREDAVEERGSSGNFRGTLEYVPGKQVTLAHVIRNPRKSLCSSVGVDHPGALGLMTITPGEGSIIAADIASKSATVNIEFVDRFTGCLLFTGEVSAVETALRATVQSLKDILGFFPAPITHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L5</accession>
    <name>D4M9L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15690"/>
    <dbReference type="HOGENOM" id="CLU_171083_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-972-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="97" mass="10267" checksum="C44FB8D8C0ABCAA2" modified="2010-05-18" version="1">MKYELIRAPSRGTQEMIRRRARGDANLGSPNWGAVLLVQGMVIEVLAAADIGAKAADVAVTELLGNCPQHINSVAFIGTPSQIDQVLNALRNGGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N1</accession>
    <name>D4M9N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage-related baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.859"/>
    <dbReference type="HOGENOM" id="CLU_711120_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-988-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014507">
        <property type="entry name" value="Baseplate_assembly_J_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020481">
        <property type="entry name" value="BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="81"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="381" mass="41680" checksum="BB990B866E9E46B2" modified="2010-05-18" version="1">MRHLIDLSKLPAPQLIEELDYEAILNEMRKKLRELLPEWTGYELESDPANKVLEVAAYREMLLRQRVNEAARGVLVAFAQGSDLDHLAAFYPDKRLEGALATFAGKLTLAAPLGMDVMIPADYRIVAKNGAVEARLMRAVTIPKGETVGAAHFEVVRPAGLDANGLNYARSWEAINPLPFVVLVEQTEVSSGGSDPESDEAFRNRARESLHQHSTAGAYGAYRYHAQSADVRIRDTEAWSPERGHVSVAVLSSEGDGSADSIMLRRVEERLSGEDVRPGTDLVAVVSAEIVPYEIQAVLELYPGVAGSPPLDEAKKRLERKVEELHRLGCDVPRSALIAAAHVSGIKKVELIKPEADIPIGRHQAAHCTRIEVGSRVADEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N8</accession>
    <name>D4M9N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15970"/>
    <dbReference type="HOGENOM" id="CLU_2436526_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-995-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="90" mass="10101" checksum="1A57F26F6410E426" modified="2010-05-18" version="1">MSAEKQRLTVLNRLSAEYPASVSLEELRKDTALHEADFRRTVAYLEEKALIDVEDLKEGVGGVFGMARITASGLDFVECSARRVRASWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P4</accession>
    <name>D4M9P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16050"/>
    <dbReference type="HOGENOM" id="CLU_2522735_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1001-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="84" mass="9239" checksum="67131D372A0D8446" modified="2010-05-18" version="1">MKRVLSLGILAAFLLSLGATLVFQVSAEGEEYMVWIATSGKGKKYHEEDCRTLKKGKRSIPLSKAKAMGYEPCEVCNPGDGEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q9</accession>
    <name>D4M9Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP-type C4-dicarboxylate transport system, large permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_16280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.899"/>
    <dbReference type="HOGENOM" id="CLU_645132_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1016-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="2">
        <location>
            <begin position="17"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="430" mass="45566" checksum="C6D4E3AD5EC9737B" modified="2010-05-18" version="1">MSWFWPEGFYALLMVAVFFAVTFWLELPIAVAMVFASLAGAAAAGEGIPLRHLVEGEFGYLDTIMVIASAMIFMKAAQRTGFLDAFAVWIIRRFRRMPAFLSLGILLLIMAPGMITGSSIASVLTTGALVAPVLVTLGLEPERAGAVISMGALLGMVAPPVSIPAMIICAGVDIPYVGFTVPLLICTLPLAALFALAMVYPAIRRFEDEGALEAQLERMNARPLTLRLSLPVLVLAALIAAEQFLSGSRYWHFLGMPAIFLIAAASALLTGVRWNPMEAAAEAIDDSLPIMSVLMGVGMFIQVMTLVGAEGFVVVSALSLPSWGLLASVLIAMPLFGAISAYGSASVLGVPFLLALSGHDVVIVASALGMLASLGDLMPPGTLSPFFAARALGVEDRFRIARRCLWPGVTVALWCLAVILMSDAIARHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R3</accession>
    <name>D4M9R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16330"/>
    <dbReference type="HOGENOM" id="CLU_060714_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1020-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061760" evidence="1">
        <location>
            <begin position="26"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="358" mass="39027" checksum="13D4AF590EA18BC0" modified="2010-05-18" version="1">MATALRRAACLLLALALSCASSSQAAFRLDVRPGYGLTRMLWLSDYNANLRGSDYDTPVYLLSGDRPGATALVMGGVHAREIAGVAAATLMVENARVREGRLFVVPCVNAAGMSVPDSLGNRPRVLEVAGRSGARFLPWGDRYIPLRPGEKDPEAFRHPSGFVLKNGAEWRNINRNYPGRADGTPAERVTFAVMELIRREGVAFSLDMHEARTFEDAMNPKTGKVGKNSLLANSLIAHPRALDLAAEALFLLEERGTSMKLEQSAPGYRGICHYEIGENTDCLAFLSETPNPGMNEWSASPDPLGLRGYPIAERVGIAVEVFRALCAAYNDRSERKIVVEGLPTRGEVQRDGLRGWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R6</accession>
    <name>D4M9R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fatty acid/phospholipid biosynthesis enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.907"/>
    <dbReference type="HOGENOM" id="CLU_711151_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1023-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="382" mass="39809" checksum="0935B1D2D16A901D" modified="2010-05-18" version="1">MSDAIKKLVGTALAELVESARSGGPKVRVGLMAAGSEHGPEEIARGARLAMQNYHNVKPVMIGPRLPGYEDLEYIECAAEDVPETLEAAVKEGRVEGAVAMHFPFPLGVTTIGRVLTPGRGTPMILASTTGTSSTVRGEAMLRNAIYGIATAKALGLKNPTVGILNVDTAQPVFRSLSHMKEKGYDITFGQSTRADGGSVLRGNDILSGAVDVCVTDTLTGNVLCKMFSSFTTGGSFEATGWGYGPSCGEGWKNVVSIVSRASGAPVIANAMGFTAAVVAAGLPALVAEELAAARKAGLDDEIAALTPRAAAAEEDVKAPAAEPTDDELHGIDVLEIDNAVKVLWKANIYAESAMGCTGPVIKMPARHMDKARELLKQNGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T0</accession>
    <name>D4M9T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inactive homolog of metal-dependent proteases, putative molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16620"/>
    <dbReference type="HOGENOM" id="CLU_064886_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1037-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="212" mass="22297" checksum="B5ED7651B02069FD" modified="2010-05-18" version="1">MRGRVLALDCSLRLTGVALGEEGREVASEALDLGRCQAAELPLMAARLLEGAGWAVQDLDLVAVTSGPGYFTGIRVGAAYAAALAFGLGVGLVPVPSLEMLALSCPDRTAVLALVYAGRGFVYAASHGVSEGCPAGEYGGEFIAEWMACHPGVQAISDDPQRAARAADLTFPIRAVRPDVRVLTQVAWARRDRAIDPKELKVAYCRAPQGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T3</accession>
    <name>D4M9T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation transport ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.938"/>
    <dbReference type="HOGENOM" id="CLU_134973_9_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1040-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="73" mass="8477" checksum="092C25983569A54B" modified="2010-05-18" version="1">MRKSYRIEVDCPNCANEMEEAARRTPGVKDVSVNFMALKMSVDFEEGRDPADVMEEVRRNCKRVEDDCEIFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W9</accession>
    <name>D4M9W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sel1 repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17470"/>
    <dbReference type="HOGENOM" id="CLU_926713_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1077-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061764" evidence="1">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="300" mass="33205" checksum="8F94A49ACB9AC164" modified="2010-05-18" version="1">MRTLRRLPALCLAALTLAAIPAPASYEEGLAFQASGDVQEAYAQWMLTSGDPRSMAAVAGLFERGDGVSRDLDQAAEWYRRAAEKGNCRAMAQLANFSLYGLGGETRSPMEWRTELEKVRGKDPYADYMLAYFYANGHGGGRRLEDALALLEPLAGSNYAPFVTLYHQVARRIEDQKDGVLDAEFLTGEIAKGEVSFDLHWRDKRLVVSGYVNSIKRLRDYGYVLKLTGPNLSVVPRDNLLAVFYAPLVTDPLTRLRGGDYVKIDGVYVGRHPFELEPSALTLFGCNLLQVTSNDADVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA31</accession>
    <name>D4MA31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uridine kinase</fullName>
            <ecNumber evidence="3">2.7.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_18770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.48" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18770"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1138"/>
    <dbReference type="HOGENOM" id="CLU_023775_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1139-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="2">
        <location>
            <begin position="286"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="547" mass="61593" checksum="A1EEF001B4409322" modified="2010-05-18" version="1">MAFTIHVLNQDKYITSETPVTGHNVLADLDSAEKGRVIAWRVNNYTRPLGWVIDDDAAVEFVLTTSPDGLRIYQRSLDFLLVIACEKTLNRKAVLRHSIGEGHYWELEDGPVTQSDVYKLHAAMSEMVHEDLPITRKILPIDKAKRIFQEQGEPEIADLFVRANLDPVEVYRCSSRYGYFCGAMAPSTGLLRTFDLLLFDRGLVLQFPTVDTPEGVPPFQADASLASIFFDYAHWLEVMNLNYLTSLHRCVAEGKVQELILIAEAFHSQRLGSIAKDIASKPVKAITIAGPSGSGKTTFSERLKVQLMVCGKNPVTLPLDNFFKEREDSPRDENGDYDYERLEALDLEMLQDNLARILAGEEVVTPRYNFITGHKEPGKVIRLGEADVLIMEGIHGLNDRILAMLPEKSRYGIFVSPLTSICIDPHNRASTGDNRLLRRIIRDYRTRGKSAQVTLEVYPKVIRGSMRYIFPYQSRANATFNSAMPYELGVLKSYVEPLLHTVDERSPVFSEALRLLNILRFVPAIQNEGIPNNSVIREFIGGSCLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA44</accession>
    <name>D4MA44_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="10" type="ORF">SY1_18980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18980"/>
    <dbReference type="HOGENOM" id="CLU_161124_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="95" mass="11089" checksum="F399792C678DB5BC" modified="2010-05-18" version="1">MPGIVHVLAYDIHDDRRRRRMAKLMEGRATRVQESVFETCQTKKQVMELIRDSLPFLNPSEGDSLRAYRVCADCMRHFQTVGGERIDWESALILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA60</accession>
    <name>D4MA60_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_19210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19210"/>
    <dbReference type="HOGENOM" id="CLU_014823_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1168-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005671410" description="Dipeptidase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="538" mass="60899" checksum="6B04C702DFC35A9A" modified="2010-05-18" version="1">MFRSRRSLFRTFLCSALCLLSFVPALACTDVVVGKDASVDGSVMTCHTADGAYYDAQIRFIPGQKYPSGTNMDVYRNIVGEEPGGWVKVGEIPQVAETYGYFHVGYPAMNEHRVAIGETTIGQKEILKTMPGGRALLAIEQLEVLALQRAKTAREAIQVIGELSQKYGFMPSCGTEGECLTITDPDEAWIFHVFSTGFGWTQESGKPGSVWAAQRVPDDEVVVVPNIARIRFIDPKDTKNFIVSDNYMQHAIDNKLYDPDSGQPFDFQAAYSPATGNDDWALSSLWIRNRLYTIHKALAPSREWDPYAPVNAYPFSIKPEKKLSVRDIMGFIRGYHKGSPFDMTMDPAWIVEGKDGVAELSPLTTPFPTRLQRNLLKIPYSRSIATNACAYSWVSQMRKDLPEPVGGVMWFGYDNPAHTLYVPVYTGTRDTKESWKSHFDRDKLSLDCAQWAFMLQDDVVNWRYQEAIKDLEAVRNPIEDDFFKKQAEVEKRAADLYKESPEKASEFLTKYTIECMDRAEKAYWDLDFSSIAKYTNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA77</accession>
    <name>D4MA77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_19400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19400"/>
    <dbReference type="HOGENOM" id="CLU_3365140_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1186-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="35" mass="4040" checksum="AB1294EE8DD9E29A" modified="2010-05-18" version="1">MENGGEIRQQAIQALYDLAILHGDIEELLKDRWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA97</accession>
    <name>D4MA97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretion system protein E (GspE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_19850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1245"/>
    <dbReference type="HOGENOM" id="CLU_013446_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1206-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="521" mass="56716" checksum="1919BF94BFAE1548" modified="2010-05-18" version="1">MSERLRSVDVRALGEDPEAAALPADGSAPLPPLPDAKEVSELLPEGMGLDVLRQGGVVPLRIDSGVLIVGASSLDAWPRAQVLGTALGCPVEVELRTESEVSELLRKLYDLRSVAADEAARKMEGIDDIEDLSREDVLSDSVDVPVIRLVNGLFVDALRQRATDIHVEPYEDDVLIRFRIDGVLQDRLRLPRTHQAPLTSRIKVMAKMDIAEHMTPQDGRIGITLGDRAVDVRVGLVPTQYGERLAMRLLDKGHGLLTLEDLGMERDERETMEALIHRPHGMILFTGPTGSGKSTSLYAILQALARPEVNIITVEDPVEYALPGVAQIQVNEKAGVTFASALRSILRQDPDIVMIGEMRDFETAHIGVQASLTGHLVLSTLHTNDSIGAVIRLVDMGIEPYLAANCMIGAVAQRLARRLCPHCMREVAPPAAMARQGLKRAFEPVGCSECHNTGYRGRIGLYEQFVVDEAVQEAFVAGATASRLREIARDGGFRTLWEIGLSAVEAGRTSPDELIRVAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA8</accession>
    <name>D4MAA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_20050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20050"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1268"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1217-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="348"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="602" mass="66050" checksum="54127DAC9214E298" modified="2010-05-18" version="1">MQEAKKNVILRVFRTAHCSPGKYILGVTCSALSVLLSGVPFYTVYRIVRLFLLASLDGTAVPTGEMWLWAAVTIGSIALGIVLSVIGSFSCHACAFNALYDLRMRILDHMGRLDLGFYTGGQSGATQKMMNENIEKMENIIAHDVSNIFGAGLLLAAFAVLMFSLNIPLALTIFIALALAFLIQFSAFGGKRGQKIWNDLNRSSTELDAAFSEYVAGMEEEKIFGRPEAAARRLTGLIEKNRENWKAYLKRVTPIFGAYKTITISVLAFLLASGCVLLHLHPGDHELMMELLMFLIVGPACISPLMELVEFGADLLNLSVRMDQIDEVLNMQPMSEGTEAAPRGGAEIAFQDVSFSYQSAATPLRRMALDHLTMEIPAGSFAALVGPSGGGKSTAGQLIARFWDVESGSISIAGRDIREYSTEALMNTVAFVFQDTHIFAESVYDNIAMHRKVHREDVERAAKAARCHDFILSLPKGYDTRLGDGGHRLSGGEAQRIAIARAILKDAPIVVLDEAMAFTDAENELALRKGMTELLKDKTVLMIAHRLYSIQDADYIFVLENGQLKERGSHSDLLQANGLYAHLWAIQNETESWQMKGGLAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB9</accession>
    <name>D4MAB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative p-aminobenzoyl-glutamate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20310"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1287"/>
    <dbReference type="HOGENOM" id="CLU_040132_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1227-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015558">
        <property type="term" value="F:secondary active p-aminobenzoyl-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902604">
        <property type="term" value="P:p-aminobenzoyl-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004697">
        <property type="entry name" value="AbgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30282">
        <property type="entry name" value="PTHR30282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03806">
        <property type="entry name" value="ABG_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="536" mass="57419" checksum="A2E10769525162EB" modified="2010-05-18" version="1">MSENPERNVDETIVAPKRSFFERFIRGIEVIGNKFPHPFWLFVVLSLVLMGLSWWLGREGLSVTYMAGKAGEAPRETTVSVVNLLSYPAMREFLAGFVKTYVNFAPLGLIMTMMLGISLLEHTGMISALMRKTILGAPRALVVAVVAVVGINANLASDAGIIFTPVIAGAVFKALGRNPWVGVAAGYAAGAGGFTANFFVAGTDALLSGITATAVEGVPTIPPGTPVHPLMNWYFMLAATLVLTGLTVYVTEHYIVKMVGDAETVRDADALKEHAVTPAENRGLFCSLLALVAYVALIVWLTYPEGSLFRNPETGAIVPRSPLLSSIMPLLFGLFFVVGTAYGIGAGVIRRAEDVPKLMQKGLIGSTSFMVVVLPASLFVALFRMSHFDTVLSVTGAEFLKAMNLGGIPLLVIFVVLVSFLNLFMISGSAKWLILAPIFVPMFAGVGFSPALTQVAYRIGDSSTNIISPLSYYLPVMLGLLEQYKPKEDTKVGIGTVISLAMPYSLFYLAGFTLLLVVWYLLGLPLGPATPATLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE7</accession>
    <name>D4MAE7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_20840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20840"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1343"/>
    <dbReference type="HOGENOM" id="CLU_016047_14_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1255-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="233" mass="25926" checksum="CDDA3ED80E16841B" modified="2010-05-18" version="1">MDWFPLWNSLCIAAISSVLVFFSGIFAAYYTARLPKTVKGFLDVALTLPLVLPPTVCGYFLILIFGVRRPLGRFLLQYGIKFVMTWYGGVLAATVVAFPLMYRTARGAFESFDMNLAYSGQTLGLSDTYIFWRIRMPACRQGIIAGSVLAFARALGEYGATSMLIGYTPGRTATISTTVYQLWRTNDERGALIWVLINLAISAVVLLAVNMLEDRQRRVAWCGGASRSRTRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE9</accession>
    <name>D4MAE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_20860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1345"/>
    <dbReference type="HOGENOM" id="CLU_041115_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1257-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="88"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="345" mass="36824" checksum="DDCB33E5010FFD4C" modified="2010-05-18" version="1">MLNAGTMGFFEALDELNSNAENVAFTVIEGEGYGEKALFSGGAAKYFSNDDGFLTAHAADLTACRETGVFDLAGSSVYGELIGHEKELIVCGAGHVSMPVIRIGKMLNFRTTVIDDRAQFAKNAEAAGADSVLCSPFHEALEKIRGGQDSYFVIVTRGHQCDGECLRAILEKPYAYLGMMGSNRRVQIVKEALAREGRDVTGLHAPIGLAIHAETPEEIAVSIMAEIIQVKNEKKNVTYPPNILRDILGKVHNPLPDPKALCTIVMKNGAAPRDVGAKMLCNVEGKTVGTIGGGCTEAWVTQCATAMLEENDPEPVLVHADLTADEAAREGEVCGGTLDVWVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF8</accession>
    <name>D4MAF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs</fullName>
            <ecNumber evidence="3">1.2.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_20970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.99.2" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20970"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1355"/>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1266-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="160" mass="17392" checksum="1126AD24AF7CBEC5" modified="2010-05-18" version="1">MTRITLTLNDEKRIADVDADTRLIDMLRDEFRLVSVREGCGAGECGVCTVLLDEMAVCSCLVPAIQADGHKITTIEGLEKDGELDVLQQAFIDCDATQCGFCTPGMILSTKALLLQNACPSREEIKRTLAGNVCRCTGYIPILNAVETAARRIAARGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG8</accession>
    <name>D4MAG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_21110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21110"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1276-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="237" mass="27374" checksum="4ABC5FC1F8F68A7F" modified="2010-05-18" version="1">MSDTNTHYESLERLIPVHLKDNPAPYYIANILREAIYRGTLPEGESLHQSQLAERLKVSPIPLREALRLLEMEGLVDFRGRRGAVVTGLTLAEMQEIYEMITALEVSVLRIAFPNIQPSAILEAGAMLDKMEREMDCIFWREQNLVFHNLLYDAANRPKTLDQIALLRQQVDRYIRIHMSLIREESQKQHRQILEAVKAHDVEGALAALTRHLEYTSRTLRACVRRTKSRNHGKEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ5</accession>
    <name>D4MAJ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">SY1_21680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1421"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="259" mass="27969" checksum="535226BCAD4A6B1E" modified="2010-05-18" version="1">MKKIYLYGNWKMNMTRAETEAFFKAFTDASAPWASRLGRELEVAVFPPFTSIWAAREAAAHLKTPPIIGAQNVYFEPQGAFTGEVSVPMLEEAGATHVILGHSERRHILGEGDDLIAKKVKACLDAGLTPVLCYGETLEEREGGEAFSVMERQLRSALTGLSAEECGRIVFAYEPVWAIGTGRSATSAQAQEVCAWSRKLVREIAQKGELGCVVLYGGSVKGANAKELLSMEDIDGALVGGASLKPETFLDIYGAYAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ8</accession>
    <name>D4MAJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized flavoproteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_21720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21720"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1426"/>
    <dbReference type="HOGENOM" id="CLU_066633_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1307-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045761">
        <property type="entry name" value="ODP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19583">
        <property type="entry name" value="ODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="257" mass="28939" checksum="8CA6D941E2BE0C1F" modified="2010-05-18" version="1">MQQLESFPLFEQKDHRFIMLGWEEKEDGMAVQTNQYVITSGREIVLLDPGGAHVFPRVLANVAELVDLKAISHIFYSHQDPDVSSGITLWLSMAERAMVHISELWVRFLPHFGIYDGRRIVSIPDGGKSLTLSGGARLVMVPSHFLHSTGCFSLYDSLSKILFTGDIGAALFPEGKRYPIVTDFEAHLPLMEGFHKRYMASNAACRSWVRRVSTLDVETIAPQHGAVIQGRENVKKFLSWFEGLRCGTDIIDQIYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK0</accession>
    <name>D4MAK0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_21750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21750"/>
    <dbReference type="HOGENOM" id="CLU_147291_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1309-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="148" mass="16596" checksum="4DDB55974F39010E" modified="2010-05-18" version="1">MKMTESLSMDQQRERFFSFLLNHPNTVAGARDRLRRKGLDEDAAEALVKEALEMALLDDALYAQLFAEGHDSWGKKRIALELRRRGVSAEDAETALADVDEGPRAKALADSWARSGLEERKVLARLYRRGFSSATVGALSRGERDVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAM5</accession>
    <name>D4MAM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22200"/>
    <dbReference type="HOGENOM" id="CLU_1852264_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1334-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="138" mass="15908" checksum="8C5E509D270C25BA" modified="2010-05-18" version="1">MGRANLRRRRNHLGLTLKELGKECGMSPSYISELERGVYGGGEALETQERILAVLTDLDMKQRASTMWHSRPERKFEPGRAYLVEDQPLRYLRKEGKHHLFRGPGGGWLTAFTDAQFVGVTIREIKRRRQSVEQADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAM6</accession>
    <name>D4MAM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22210"/>
    <dbReference type="HOGENOM" id="CLU_153287_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1335-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025518">
        <property type="entry name" value="DUF4406"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14359">
        <property type="entry name" value="DUF4406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="123" mass="14146" checksum="1113C1E66D64A7BE" modified="2010-05-18" version="1">MRRVYIAHPLRGERLDIAEMERNVSRVTEICRHVAEEHPDVLILSPIHAFDFVSPLGPQDWVMRQCLALLDVADELWAFGDWERSEGCRMEVAHARAMEKPVVFKDRAEDVRPYGAGESEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN3</accession>
    <name>D4MAN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytotoxic translational repressor of toxin-antitoxin stability system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22280"/>
    <dbReference type="HOGENOM" id="CLU_155761_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1342-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="87" mass="9983" checksum="E61FCA93235E37D3" modified="2010-05-18" version="1">MSCWQLIISKEALKALESIPKKQRDRLWSSIKRLTGGPYDSGLDVKPLKARPEWHLRVGGWRVIFRVEQDRLVIVVVAVAPRGDAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAP1</accession>
    <name>D4MAP1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_22410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22410"/>
    <dbReference type="HOGENOM" id="CLU_011142_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1352-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010810">
        <property type="entry name" value="Flagellin_hook_IN_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07196">
        <property type="entry name" value="Flagellin_IN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="812"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="898" mass="95310" checksum="7FFB314B78A3F025" modified="2010-05-18" version="1">MRIYHNVPALFAYNALNNTNRSLQKSIQTLSTGLRINSAADDAAGLAISEKMRAQISGMNMAIRNAEDGVSMLQTAEGALASTHSILQRMRELAVQAANDTLTQQDREYIQLEVDQLKDEINRISTATQFNNKKLLDGTSAGIWSSTDLATKAYIRGSLREIDQFGQKSAFEGNYKISITATPGQAEAKKTDIFRIKHPNVTMGVSLNDKAGASALRVDNLPAGTYTMRTLNTAANSDIAKTGSYGIPADLYTHKLESRVVQAGAAGTAGNIEDYNGKTLTVELDGVSKTITFATTATTTVADFLAQINAGLPEGVKATEAGGKITLTYTGPKSTTGILKVSGTSITPVGGGGEPKAALFATAASAAPTGPVPPLNAEMGATPANLTGNASVLLEVVSVNEKAKSVTFKGTANILMEDGTVKNVVKDNIVMSEGTPIDLKDLGLGTDSLKMTLNAAAGFKVGGKIVYNVTKKAAANAQTVEIEGQQTETWPYKWGGSVSDATLKFGLDAEKVKEKELHFRNFYLNDKNGTVYEGDIVLTTNKTAMTADKTLATFEAAYVGQVAKSDVKLRDLEKFWTTQGVFMLTDPQTITISQGDGKSTKITLHATDTLGELRSKLNDAIANGLGQARFAVSNANDFVTFVGKGTEKDYGLETVPGTFIIRSLVAGAAGRLSFSGNEDLVNALSLNVVQEAKENSFTASVYDAHTGATIASNVKVSGNQLIGVIHKNVDVEFDPMANIKVTWNENLRNFVLSADGTPYETVLHIVDNSTIFQVGANEGEDLAIDIGNMGANALGVTRVIVTDRGSATRAITILDTAIGKVSTQRAKIGAYQNSLEHTVSNLTTTSTNLTAAESRIRDADMAKAMMEFVKLQVLNQSGTSMLAQANQLPQNVLSLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAP9</accession>
    <name>D4MAP9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">SY1_22570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1500"/>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="301"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="333"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="415"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="431" mass="47093" checksum="665A2BE6CE806DDC" modified="2010-05-18" version="1">MKNNVDLLVGAQWGDEGKGKVVDLLGADVDIFVRYQGGANAGHTVIADGEKVVFHLLPSGMLYPGKLCILGNGLVIDPEQFLKEIANLSEKQQDRARLAISPRAHVVMPYHKILDQAQEKARGKGRRIGTTGRGIGPCYVDKYSRCGLRIEDLLDADVLRDRLTPLLEEKNQILTRLYGEKPLPFDEVYEPARQWGKTLAPYVDDVAVLLRRAVDDGQHVLLEGAQAALLDIDHGTYPYVTSSSTSAAGAFTGTGLSPHDLNRVIAVTKAYTTRVGEGPLPTEDLTEAGETLRRNGGEFGATTGRPRRCGWLDLVGLKYSMALNGADTIALTKLDVLTGIGPIKVCVAYEYEGERLDRFPVSTRVLEAVKPIYETLPGWSDDIARCRTIDSLPQAAQDYVRYIEKELNVPVGLIAVGADRDQAINCGLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ8</accession>
    <name>D4MAQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein (DUF2232)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22690"/>
    <dbReference type="HOGENOM" id="CLU_068641_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1369-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018710">
        <property type="entry name" value="DUF2232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09991">
        <property type="entry name" value="DUF2232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="319" mass="35315" checksum="7CD7E7927DFE745B" modified="2010-05-18" version="1">MPGPESVFKQRTLGRVVFFSLLTVLLLKVKDYVPAVTFWGLFFSPLPLALLGCREGRRSLGLGVLLTGGLTALLLSIPSALYFVTASAPLSAALAASSRKSWSGGEALLACTFVSVTEKLFFFFLLWALTGRNFLAPDAGQVEEMMGRLYAGFSSGFRETISTQENMRQAAALLPYMTPSMLLLYAGLDALCNYKLCGYFQRGQAHRPPALPAFTEWRFPKSLLSAFFLAFVINLLWGLDDWRAGALFAANLELVLNVLFFVEGLSLAFWWIGRRGVGPVLRTLAAVLFLIPLAWPWQVLMGIGDIVFDFRSRATRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS9</accession>
    <name>D4MAS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, TatD family</fullName>
            <ecNumber evidence="1">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_23000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.-" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1545"/>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1390-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="260" mass="28943" checksum="D795405A21FC9306" modified="2010-05-18" version="1">MLIDSHCHPNSDELRKDAEALVERAASAGVGRMLIVGCDLEDSREAVRMAHRFEGRGAWAAVGIHPHEASRYAEALPEELLQLAGDCRTLALGEMGLDYHYDLSPREVQREVFRRQLAWAEGVGMPVVLHVREAMEDALAILRDFRGLKLLFHCYDGGLKFLDEALGLGALCALGGAVTWKRSVELREVARLIPADRLLTETDCPWMAPVPFRGRLNEPAYVRYVYEALAEARGVPPEELADQIARNADGFFGWGREAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT8</accession>
    <name>D4MAT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_23210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23210"/>
    <dbReference type="HOGENOM" id="CLU_027686_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1399-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="362" mass="39344" checksum="ACE101C7C8CF8BEE" modified="2010-05-18" version="1">MKTYPIALVPGPTSIPQRVRDAWNTDFGSSDLEGEFFELYADNQKLVRRLLGTKGDVVITLGEAMSILWGALKCTLKPGDRLLAVASGLFGEGFADMARAIGAEAELCAAPHDQTPDFKKVREAALRFRPKVITAVHCETPSGTLTPCIKELGEIAREVGALFVVDFVSSAGAAAVDVDENGIDIGLLGSQKVLSMTPSLSISTLSDRAWKVIEEVRYSGYEAYLPWREVPAVHAMPYTHDWQAMAGLHAALSAIMEEGLEHAYDRHERAAALCRRRGREMGLRLFPLDEAVSSPSVTAFYVPEGWTWEALDAALRARGLALGGNYGSLAGRVFRVGHMGSQADEALVARGMDVLKDVLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV4</accession>
    <name>D4MAV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_23420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1584"/>
    <dbReference type="HOGENOM" id="CLU_1756155_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1415-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061870" evidence="1">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="148" mass="15922" checksum="AE4F4D3E6157B8C7" modified="2010-05-18" version="1">MKKTPILALTALLAGILSFGSAMAAPTNATEVTDMKNTAIQELTNDSRVFAKDPSIQVRSAHVNAPVIKEFPVAMECELLEIVDTENLHCVIGKIVGVSADEKVLDSKGKVDPAKLNAFAFDQFQNGYYKIGEKVGQAWKAGAGLMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV7</accession>
    <name>D4MAV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_23460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23460"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1587"/>
    <dbReference type="HOGENOM" id="CLU_120467_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1418-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="137" mass="14729" checksum="D7D392B6B571FDEB" modified="2010-05-18" version="1">MWFVYAMLSAAFAAATSILAKVGIRGVNSNLATAIRTTVVLTMSWGIVWLTGAQSGLTEINRRGWVFLILSGLATGASWLFYYRALQLGRVSQVAPVDKFSIVITIAMAFFLLHEEVAVKTLVGAALIAAGTFVMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX2</accession>
    <name>D4MAX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RND family efflux transporter, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_23760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23760"/>
    <dbReference type="HOGENOM" id="CLU_739174_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1434-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="374" mass="41247" checksum="CA026AF6873B7CAA" modified="2010-05-18" version="1">MWRNLMGVLNKVRVLLWVGALAMVGTLVTVQVMAKMEQAEANLRSLERETETVYPVTTEVLKTSDWNTWRSYYGQGKSAHTQNVTAYEREIVRAVHVQVGDRVKPGQTVVTLMVADRGARVQAQLTGYDEAKLNYNRLKELHAKGGISQSEVDSAYATLKSAEAQLKSSQSTLQRTELKASIEGIVAARNVEAGEVAEAGMTLIAIVDPREMEAELMVSKKDIFKINRNTSVDVYVDGVRSAGWVKRTSPEAQTGSGLYPVVVGLPEKSGILPGSYLEGRFFGGPSAGRHRHPLQRRDLPQRRPGRVPGVGRRGPQRPHHHGRRARGPRGGHLGAQGGRRTDRQRQPRALRGRRHHAGRARRGSEDVGGTRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y5</accession>
    <name>D4M6Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <ecNumber evidence="2">2.3.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.29" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1727"/>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-11-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="409" mass="44670" checksum="98374C31408C6675" modified="2010-05-18" version="1">MKIMKKLEAALAAELERLKQEGRMKGKEEIIVEVKRAAGSRGPRYLLEGRGGKEFIRMNSNSYLGLALREDMIAADEEGTRRFGVGPGAVRFISGTFKAHRDLEHRLAAFHGREDAMIFSAAYVTVGGVITSLISKETFVVSDELNHNSIINAIKLGRPPFRAVYKHNDLGDLKRCLDEAKAGTAKRVLVVTDGIFSMRGDHAPLKEIQELVHSYDEHFAEGAFLVVDDSHGVGACGRTGHGTEEMTGARVDVLIGTLGKAYGVNGGYVTASRALITYLREHAAMYIYSNPITVGEACATMKALDILESDEGAKILEHLRVMTKRFEDGLVKLGYETIPGEHPVTPLVLHDTDRTRAMVAHLLENGVLATGMTFPVVPRGAEEIRFQINADHTEADIDEVLAAIGSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z2</accession>
    <name>D4M6Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00460"/>
    <dbReference type="HOGENOM" id="CLU_147162_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-18-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="106" mass="12518" checksum="3A9ECA22C59A388B" modified="2010-05-18" version="1">MDDEHFHVRFTPLAYEDMDEIDDYISVTLGDPEAAEKLLSKIEQELQHLTRYPRIGAQPRDTFLASRGYRKLVVENYLVFYILHEAEHEAVVMRVLYGAREYRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z9</accession>
    <name>D4M6Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook capping protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_00610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgD family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2195"/>
    <dbReference type="HOGENOM" id="CLU_047535_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-26-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="145" mass="15585" checksum="E0CFC549D6D58CA9" modified="2010-05-18" version="1">MPVNGVAGAVNTDPSAATGAVRQNELDKNAFLKLLIAELSNQDPLNPMEDREFIAQMAQFSSLEQMQNMNKTLESMAQASKFDAVSYIGKAISFNKITKDEKGKEVETPTAALVRAVFFDPQKGPILDTAEGQVELAKVLGVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M707</accession>
    <name>D4M707_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00740"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.173"/>
    <dbReference type="HOGENOM" id="CLU_025908_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-34-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="317" mass="32958" checksum="59EB99E9B2599DAA" modified="2010-05-18" version="1">MGSTGGGRVCAAVDIGSNSIKLRVGCCAAGGVQVLLDTTEVVRLGGCLRDGAIPEETMGNAVRVVSEMVGRARRMGAEPCLVGTMALRVAANAHEFLSLVHRRTGLEVRILSGEEEASYSWKGASADFARNGGDLVLFDTGGGSTEFVFGRRGAVERIQSVPVGAVSLTERFFAEDPPPKLALDEAMACVREALSANGIARAHPGTAPAVLGLGGGAVAIGSVKDGSATFIPTRLHGMMLTRKDVAEQVELYASLPLAERRRIAGLPASRADIVLGSACIILGAMRALDVECFTLSINGLRHGVLLEMCEGPRSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M731</accession>
    <name>D4M731_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01100"/>
    <dbReference type="HOGENOM" id="CLU_097479_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-58-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="168" mass="19751" checksum="B6824C00170194C5" modified="2010-05-18" version="1">MGLSWSAMRKVLEHENICDSLKGRVQYFVTRYRESHDQEGRVAVRLDGNEIFKSNFYDGEIKRREAWNEINASKGRPTDYAESGEQMELEALNKGGFERFAFYDAFYRYQNSGINDSLQSSDPVVRLFAILDKRVGKRRLHKMISEIEQQPIWLKPFYRLRLESDGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M754</accession>
    <name>D4M754_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_01460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01460"/>
    <dbReference type="HOGENOM" id="CLU_055769_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-81-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="134"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="288" mass="31763" checksum="7ACEE55BFD8D1FFC" modified="2010-05-18" version="1">MNEMKDVASKIRGLYDTFSKGHQSLAEFILNNPQESAFLSISALSDKTGISAPTITRFVHKLGFDGYATFQRELYEAQAQIMPFSQLKSLLRNSAGSSPETATGKGALFLGIEANLRLMEALYTPQLQEAFTRTLGIIQNAHKIYIAGQRSSFSIAHYLSFMLQRIYSNVVPLNATASALPSELSDVREDDCLVAISYSRYTKATYNVVSYFHRLGCKIAAITDSPTSPIALKASEVMIAPNGEYFSPVCAMTLCNCLIAALGSLDVQRTLERMELQDNIAIEHDIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M783</accession>
    <name>D4M783_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_01900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01900"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1031"/>
    <dbReference type="HOGENOM" id="CLU_054938_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-110-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="337" mass="35870" checksum="804F52B2C2C307AF" modified="2010-05-18" version="1">MSLFADDKNLALELVRATEAAVMASGRWFGRGSKNDVDRSAVEAMRYMLRGVAMKGVVVIGEGEKDEAPMLFNGEEVGAGEGPEMDIAVDPIDGTRLLAQGLGGSISVVAAADRGSMFSPQDLFYLDKIVTGVEAADCIDIQAPVHVNVKAVARAKGKAVEDITVVMLDRPRNEKIRDEVRAMGARLRMIPDGDVSGALTTCLLGNETADLLLGSGGSPEAVITACAVKCLGGNMQCRPFFRDKKDEEKANARGLTRDTVLTLNDLVKSDNVFFAATGASDGDLLKGVHYQGSHIQTSSLCMRGISGTVRYISAVHSPKKLSEMGSAIDYSPNKNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M786</accession>
    <name>D4M786_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01960"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1139"/>
    <dbReference type="HOGENOM" id="CLU_469100_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-113-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="581" mass="64971" checksum="E2BC9B397D4990EB" modified="2010-05-18" version="1">MDEATLEPTRESVLEEIKKCRQKIGTLLMIYFMVVLLQVVSGAGNLLLLFLGTAGGMSILGKALFAALPLLMWFYSQRPSSTGGVLMFYAVVEGIQAAILLAVVSVGSFFFGFDGPSSVAMLPFVVLLVFGVVGGLLVLFVKLFRSASRLGQLMAAVGGASGNFRAACLDAVMVVVAIVCYLAPALPAWDSVQSSRNLREELNQAPEVKIYRVKEVINCMAGSPDGSLLALGTEKGLYVWDTGGRECVWSDDCLAVQRVRFSPGGRYLAAAGRGRVEGTSDLAVYEVEGFRRLPGFDWPEHEEHKEKVFHDMVFRPDEETLLVLWHRSWIWNRMPQGWYGDEADAVREREKDLGHDLDTVDLFCTEGNIKKNALSSFRRIRKGLSVDFDLCVEGSAYFASDASCFVYSIEGMQKEFNRFCLMDTEKWQEQLFHLSGYQLILWGIKPWYEWRLNANGTRAYLLCEKELKEGGYEGVLLELDLQTGRTRELKSRGWRLALSADGEQVVMLAGNNQVSGVVLIALNFLNLDTLAEKQLLYKVVQRDQGDSWRFIWLKPRLFAVAMKSEYGGTLTFIDLKEGEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B2</accession>
    <name>D4M7B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02310"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1683"/>
    <dbReference type="HOGENOM" id="CLU_131458_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-140-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="147" mass="16794" checksum="6FF5DB807E25F8E2" modified="2010-05-18" version="1">MIKGGRNMPEGYDRVAHLGFIQGAINRMAGNSFLCKGWAVTLFSALSAFVVSAEGSHVLCVPWLLAAAVLVFWWMDSWYLRMERLFRRLYDRVRLGDEAGNPYDMSFKPFMGEEQCVFRIMFSRSTLPVYSVMLVAALVLFFVRRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B8</accession>
    <name>D4M7B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02400"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1696"/>
    <dbReference type="HOGENOM" id="CLU_1238472_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-146-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="232" mass="25659" checksum="5D4D5455A8A29A45" modified="2010-05-18" version="1">MGSIAEARAEGDWYARNMNAANLEEVYRTRLPRVRQYLEAEIGFVRSFLSGRERVLELGAGYGRIVKELAPFTASIVGIELSEASVAFGKEYLKDVPNAELKVMDAHHLHLAAEFDVVLCLQNGLSAMKGDPLNLVRQAVSVLLPGGRALFSSYSPKFWEHRLAWFQEQAEKGLLGAIDPDRTKDGIIVCRDGFEARTFSLEDLEALGNAIGCDHFLEEVDASSVFLVVTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G8</accession>
    <name>D4M7G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major membrane immunogen, membrane-anchored lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03110"/>
    <dbReference type="HOGENOM" id="CLU_119924_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-198-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="1">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="137" mass="14455" checksum="187738F43ABFF179" modified="2010-05-18" version="1">MKKHTLLLVGAAALMVAGTAGFMNLRPVGYRDGVYSGSASGAFGETKVTLTIADGRIAKCDMEALDDDGNVKDAHYGEGSSEANFRMAQTALQGIGEYPKKLIESQNVDGIDAVSGATVSLLDFRNAVKQALEEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H4</accession>
    <name>D4M7H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">Histidine ammonia-lyase</fullName>
            <shortName evidence="5">Histidase</shortName>
            <ecNumber evidence="3 5 7">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hutH</name>
        <name evidence="9" type="ORF">SY1_03200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5 7">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 5 7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03200"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1799"/>
    <dbReference type="HOGENOM" id="CLU_014801_4_0_0"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Ala-Gly)" evidence="5">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="522" mass="56005" checksum="30B0E35F16BBBDBF" modified="2010-05-18" version="1">MIMNPSAVKRVVMDGKSLSLEGFVAVARFGASVELAGSALRAMERSRSLAEKIAGEKRAAYGITTGFGDFQKVAVPEEMSNQLSTNLILSHCTGTGDPYAAEVVRGMMLLRANALCGGVSGVRPVLVQMLVEMLNRGVTPVVPQKGSLGSSGDLAPLAHMTLPLLGRGRALYRGVEMSGAEAMEKADIPTLSTLACKEGLGMTNGTCAMTSVGALALYDTICAAQLADVIASLSFEGLTALKDAFDPRVHQVRGQRGQIRVAANMRRLMEGSEILDRCQGDRVQDAYALRCVPQYHGAVRDALDYVLDKVEIELNAVTDNPLLFLEDEAVISGGNFHGEPMAIPFDTLGIACSELANISERRTERMVNAALSNGLTPFLTTKAGVNSGFMIVQYAAASMVSENKVLAHPASVDSIPSSANQEDIVSMGTTAARKAGWIVQNTLSVLADELLTACQAIDVRRRLDTHGQGITPLHEALLKHVRERVAFYEVDREIWPDIVEVEKMVRSGELLEIVRAHVPDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J6</accession>
    <name>D4M7J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permeases of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_03650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03650"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1846"/>
    <dbReference type="HOGENOM" id="CLU_033863_21_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-226-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="304" mass="32583" checksum="2916E9A2B51AA55B" modified="2010-05-18" version="1">MDSRALRGNLLLLVTSAIWGFGFIAQQFGSRALPPFSFNACRFALGSASLLPLIVIFGWHDPARRRARAASRRLSVQGGLLNGGVMFLGAWLQQAGIAETTAGQAAFLTGLYILFVPLLGLFMHHRVPLTTWCAGILALVGLYLLSVREDLSVSRGDVFEIAGAVFWALHILCIDAYVKRTDPLEFSFWQFAFCALFSVGTALSLEPGGFAHVGDALLPILYCGVVSVGIAYTLQVVAQKDVIPAHAALILSVETVFATLGGAVVLGENLGLRGYVGCVLMFSGMILAQWHGLRGGMRPADVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K5</accession>
    <name>D4M7K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type oligopeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_03850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03850"/>
    <dbReference type="HOGENOM" id="CLU_017028_0_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-235-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003060998" evidence="1">
        <location>
            <begin position="36"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="86"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="548" mass="60969" checksum="5F681B21CDD40B85" modified="2010-05-18" version="1">MMKYRVKRMTVSSSAAWALSFCLVLSSVFAGTAWAGEPQVLRIPIDEEPDSFNVARVSDYYSAMVASQVIEGLTGIVVRDGREVAVPACAESWETSEDGLTWTFRLREMKWADGEPLRASDFVYGISRVLDPATASPISGKVRFIKNAGDVLLGKKQPSELGLEAPDDRTFVVRLEHPVPYLLQSAAGTAMFPARRDVVEKFGDAYGTDADKVVGCGPFNLADWVHNSSIAFVKNPLYWDADNVKLDRLEMKVVAEESAKVGDFENGGLDLVSIYSVEWAKKLDEKGGYVKNVVAMPETKYVFFNQTVPPFSSPKVRLAFSLALDREEIYRDVSLGLDPAAWGWLPPAMGLDGENFRKLAGDPIKDLAAAHPDPRALLAEGLKELGMSEAPEGLKIVLMCHNATRDFAEYLQQAYKTRLGVDLELDPVEWPVFQERNRNLDYQMGYKSYYADFNDPSSMMDLWITGTRTIPTGWSNERYDALVREAGQSADKALRAKDYAEAERILLEEGTIAPYAYSTGFDYVHPYVKGYAAPTFTAMLYKTVSVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N6</accession>
    <name>D4M7N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_04300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04300"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1917"/>
    <dbReference type="HOGENOM" id="CLU_056939_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-267-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027839">
        <property type="entry name" value="DUF4432"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14486">
        <property type="entry name" value="DUF4432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="338" mass="37863" checksum="58A8ED4D82398943" modified="2010-05-18" version="1">MEGLSMESLYRHVGTEEQVYGVRRLILDEGNARGAAVYQVSTAGGLDFDVLPDSGLDVGRLRWRGVNVNYMTKNGYDAPSRFLPVPDNFDHTFPGGMMYTCGLLSVGPQCRDEEGDGEFHPLHGRYHGQSARGLSASAEGGVIRVSGTVRETEQWRHNLSLKRVITAPAWGSELLVEDEVTNLTPQPVEYALLYHCNFGWPLLDADATLELPEDRKVTPRSPWAEAGLADQCRCTAPIDGEEERVYFNEVRPAGEDPRARLINRRLGIGAELSWSLDTLPILSQWKCMRSGEYVLALEPSTCYTMGRLEERRHGSMRTLAPFASVRTRVRLRFFDPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q0</accession>
    <name>D4M7Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_04530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04530"/>
    <dbReference type="HOGENOM" id="CLU_2972876_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-281-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="58" mass="6445" checksum="CE54CFE2E04E75D6" modified="2010-05-18" version="1">MALDIPSPWFVESLELAPAAKRLDIHLDFQKGSKFTCPECGAEERKVHDTANALMCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S8</accession>
    <name>D4M7S8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="2">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_05090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2003"/>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-310-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006815">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="436" mass="47077" checksum="07E9F495B7112E3C" modified="2010-05-18" version="1">MRYLSQTPEDTKEMLDAIGVKSVEDLFDSIPANVRRDAPIDIEPKSEWALSKEIRALAAQNFSGTAFLGAGCYPHDIPAHIPYLAMRSEFLTSYTPYQPEVSQGTLQAIFEFQTMTANLLGTEVANASMYDGANSVAEGALMAIRVKKKHKVAYSRLLHPHYVEEMKTYFRPAGFEAVELPVLPDGRTDLSKVPDDVSAVVVQSPNFAGVVEDLEAAAKAAHDKGALLMAAFTEAMAWGLLKNPGSCGADIVAGEGSSFGLALNAGGPALGLLACSMKNVRTMPGRLVGQTVDRNGNRCFVLTLSAREQHIRREKATSNICTNSGHCALTAAMYMASAGRGGLHAIAKLNHDKAAYLKGGLEKAGFKPLFNAPFFNEFAMKAPAGFEKKYGELLKKGFAAGLDMGRFFPEYKGVYLFCATEVHTREAIDAFLKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T7</accession>
    <name>D4M7T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05190"/>
    <dbReference type="HOGENOM" id="CLU_3429803_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="19" mass="1908" checksum="4D3A40A614A6339D" modified="2010-05-18" version="1">MAFTAVAQTVAGAHHLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U0</accession>
    <name>D4M7U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sel1 repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2019"/>
    <dbReference type="HOGENOM" id="CLU_481256_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-321-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061515" evidence="2">
        <location>
            <begin position="34"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="566" mass="64768" checksum="C11EFD4C8879431B" modified="2010-05-18" version="1">MWKTMERVWKRSVAALLLAALLCEAMPVGPARAQEDYDRLNTMLTLNMAIVSVHRILKTKDRIVLEQEYQNIINNLSLGEIAPDSNLIDLYEELMDFMTRKLLNGKQMERFRKRYVRREKQQFVRSLSSVSAQGESLRSFLDSLAVSCVSAYFGYQAAINEIREELEDKLWEISDKEMEDCNELQKRLLKSSWTLLHLYGLPDEYRLTQDSLNDFYEAVRQSDASQRLRMLRSLEREFGVYPPYWFYRGRAARDAMNTEEECRCFDQFDEVWRPVLKSDPYKLEVAKYRIEKLMAPDRKGRWDTDAITKQLETLRKHAPRNDWGSRLFAGIAYFQLGRKTEGENCIRDNIDYGCEKNVSGHILDLMKQGTLNPDEWKTILVEKIDLDGDGAEDRECPRKALSRFVELANDGNLSAQCLMGDNHCLLGEYGEAAEWYRKAADQGLAKAQKALGDLYARGDGVGRNVPKALELYQEAAKQGMAEAKKAMGDLYARGDGIGKNVPKALELYQEAAKQGMAEAQKALGDLYANGADGVGKNVPKAREWYQKAADQGNQEARDRLAELDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U2</accession>
    <name>D4M7U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2021"/>
    <dbReference type="HOGENOM" id="CLU_106275_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-324-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="230" mass="25476" checksum="9C0AC432964125C8" modified="2010-05-18" version="1">MKTFQAHLDILPEAQRELWNKLSPCGALGFVLYGGTAIALHLGHRVSNDFDFFSRLPLSEAMEKKMLESMPFLKMAELLQNELDTRTYRTTEGVKLSFFGGIAFGRIGEPLLTHDGILQVASLKDLLAMKAAVIMKRVEAKDYRDIAAILRSGTSLSEGLSGACAIYGDRFPVIESLRTMTYFQGGDLDQLSENDKKTLIEHTKSFKLDDVKQVKILSHDLSEPGSATAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V0</accession>
    <name>D4M7V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2030"/>
    <dbReference type="HOGENOM" id="CLU_298050_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-332-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1009" mass="115196" checksum="036F340D4CEB34DC" modified="2010-05-18" version="1">MNAPSLKIRITGLPNFVQNCFGNNSDLANCMGIIAQNKVEDKELVQAVLSEYCDSSETVISEDLINMKLDREWDIARSRKNKPKMKLAFDARRKVFDAFLERLTLMMEWGNIEEVDDNRCNHLRSLRAKTLNDVNAIFMKSEELKAAPGNVFVLKMLKVIHDRLSGHHVKPLFMDLLTTRFIPLDNEGNPILTTEQCAIPYYEPWRNVLRHIASPARSLNEARQGIFDNSAPDETTTFDNLNQLELIDRAEGKEIQVHDDITAVQNSAEKRLDSFKGQLELAYTYGRIREDDKENLTNIQMRYKPDFFDGRNFGCWRQFLNALEQKVTDLTAERKKQLKNDIKIRRANLDEKQKTFSTLDKAEKLLDEDNFAVAEEYINRFDYGEYELTKELQTVMTSGDSFRDFLSDESFDPLYDLCSRNSSRKLGDFSKDLDKARPKDWSSRLKTSSEKLVEAWPSRRGKTTTDQIKTLFFCLGFNVIKAEKIDCDQKAPDQFKVFVQKSPRNASDYDHPIAAFGTKMASPLSVVILYGNHMADGIVKTVTALNLNPNGIAVVLVDYYLDRGTRRQVAEIFHTQTSGQKPFLLIDRVLALHLALHLPTERLSILLKCTLPYTIYQPFVSGVGAVSDEMFFGRRKEIHDITDPNGASIVYGGRQLGKTALLQRAENLRFAPENGAFAVLSTIKEFHKEEQVVEHVIKDIVEKTNLPITPCASLEDMCRQISSLFRQEKIASFLLLLDETDNFLESIGSVDYNPLLPLVNLKRETQNNFKFVLAGLHNVCRAKNTLSSNNVFGQLGTPLCIQPLSPVDAMDLISRPLHYLGFQVGDAHLQTILINTNYYPGILQFFGYTLVQTLTSKYAQYYHATNNPPFVLNDMQLGNVMADESLNDSIRSRFHLSLNLDQRYFMLARCIALLYYTQEEYLVGDQHGFTQKQISDCAKEYQIYCLEQLSSETTINLLDEMVEMGILGRPESGIYRLRRRSFLNIISHDDSSLLDDIDKANNPEEAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X2</accession>
    <name>D4M7X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_05670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05670"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2060"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-354-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="133"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="336" mass="37350" checksum="6C1AC99820F5CC2B" modified="2010-05-18" version="1">MTEPIIEPGHEFERIDVTGAAHIDRDCASQPFWRDVLSRFARNRGAVFGAVTILVIAVLAAFGPGMNEHAYNDVNILHQNLAPRIPVIERLGVFDGGERRVNRYRQKGLDDVYYWFGTDTFGRDQWTRTWMGTRISLYIAFVAVLIDMLIGMSYGLTSGYFGGATDMIMQRVLEVVNGIPTLIIVTLLMLVMPPGLNSIILALLITGWVGMSRVARAQMLKLREQEFVLASRTLGAGHFAIIFRDVLPNIFGQLVTMSMFSIPNAIFSEAFLSFVGLGVPAPMASLGSLINDGYKSFLMHPHMLVFPAMVLALLMLSFNLLADGLRDAFDPRMQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z5</accession>
    <name>D4M7Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06100"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2097"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-377-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="248" mass="26570" checksum="D2BD1FB56273DF6C" modified="2010-05-18" version="1">MQSLLKGKAAIVTGSSRGIGRDIALAFAENGADVVIHGTREQPDLRDRIRATGVRCECAAGDIGDYSTAERLTAACLDAFGRIDVLVNNAGVNSRTPFADLSLEEWERVLRTNLTGAFCTCKCVVPHMLRQRSGCIINLSSSAGKTAHPNAALPYGVSKAGINSLTQKLAWDLAPFGIRVNAICPGPIETDMTRQWIPEYREEVLKSIPVRRLGCGADVANVAVFLASDMSTFIVGESINVNGGKYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M803</accession>
    <name>D4M803_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_06210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06210"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2107"/>
    <dbReference type="HOGENOM" id="CLU_019824_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-385-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="10"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="432" mass="46358" checksum="ED5DA004D0161D61" modified="2010-05-18" version="1">MSPIALSAAIMLVLLFANVPVFASVVGACIAYFVSAPDTGFTAMMATQRIISGMQSVTMLAIPFFVATGVLMNYCGITGRMLQFCKVLTQHMYGGLGQVNITLSTLMGGMSGSSLADAAMEAQLLVPEMRKAGYSNGFASAITAASSMITPLIPPGIAAIIYGSITGTSIGRLFVAGILPAAVLCAAMMIIVSRFSRKNGIPRLSERRATIYELWEAFKPAFLPLCLPIIIIGGIRMGIFTPTEAGSIAIFYALLLGILYQEIRLDNILTCIKETVATTASIMLIVGAATCFSWILTWENIPQTMTAELIALCHNKYVFLLAVNVFLLAVGMFVEATAAQIVLAPMLAPVAVAFGIDPVHFGMIFIFNMAIGSITPPMGNLMFVTCGVTRCTTGDFIRECRVFYALLIIILMLMTYVPFLSTWLPNLLYGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M806</accession>
    <name>D4M806_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.262</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.262" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06240"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2110"/>
    <dbReference type="HOGENOM" id="CLU_040168_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-388-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="357" mass="37851" checksum="26CD5DD6748A91EE" modified="2010-05-18" version="1">MDKPILGITMGDPFGNGPEITVKALADAAVYDRCRPLVVGDASSIRYAAAAARTLSGADLEVRPVKAVSEAAFTPGVIDVLDLGLVKASDIPGDPAAPKPFGLGVTKLGGEAAFQYVVRVIQMAMAGTVDATVTNALSKEAINLAGHHYSGHTEIYADYTHTQKYTMMLAHENLRVVHVSTHVSLREACDRVKKERVLDCIRIANDACLALGIRDPKVGVAGLNPHCGENGMFGTEDIQEIQPAIDTALAQGINVPDRKPTPPDTIFSKAIGGWYDIVVAMYHDQGHIPLKVKGFVYNKAEKRWEAVAGVNVTLGLPIIRASVDHGTGYGHAGSGGANALSLVNAMDYGIRLAEHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4M810</accession>
    <name>D4M810_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06320"/>
    <dbReference type="HOGENOM" id="CLU_083287_11_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-392-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="159" mass="17973" checksum="37E5908AE1C7CD55" modified="2010-05-18" version="1">MKIINEANESKVSYRLLNVMLKLQEAQERLHRYGTDTPLFAAEIHLIKCVKENPNRHMTALAEVLGVTRGAVSQIAMKLEEKGMLVKEKDEGSSLRRILRVTPDGERAYRFHERLHADFDRLVEGLLSGAAEGERLFLLDFLGALDAALEGKFQSCAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M846</accession>
    <name>D4M846_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2174"/>
    <dbReference type="HOGENOM" id="CLU_709110_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-429-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="389" mass="43299" checksum="1A3D1E99037AAB52" modified="2010-05-18" version="1">MDDKGEIVSSHDVDDNLSLQIWTKGHTPRLVIFNKAKNSKKLIRLGWVEKRDRKLAVSGKKRGESVNYTIQDFEPTLQRILTEYAVYANFRIKLWRFAVELEKIVNAPEIVTDSGEMNLLTEDKRSSFWIADCTGPDRKAGFFRPFFPVSGAEADAVAGDRLRIAEGNRGVEALLKTGVLRDLAKANPKRWHNPVRVVAAAMLLGFSYCEEDGSDFSDELWGAGAEGGGEDAAAAALTGTVKFTLRDPRLLGLGRKLVAFVRHFDAVPQVEVSNSVDSDKELQEQGFGRTRRLEFGAGTIGDVPYKVTFFEHEDGRIALGCKPEAATQRHKGELVLTLPGDVYRTALKQDTMGGPEDDFYTTTQLAWACQFKEWLDNITPYISNFAGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4M863</accession>
    <name>D4M863_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="9" type="ORF">SY1_07150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2204"/>
    <dbReference type="HOGENOM" id="CLU_087843_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="8">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="180" mass="20108" checksum="9091A4C394895F2D" modified="2010-05-18" version="1">METDVSEPARRAQSHHRSRQERGYAARRRARELAVQFLYSMECGPGQDLEEALELFLGAESCAEAEPPAVKEYCRALVRGTWSRRTEVDEVLLSVVTNWRPERMVAVDRAVLRLAVFEGFLDCALPFKSAISEAVNLARSFGTEDSARFVNGVLARVVRRLIPEERKEGGADGQGEDPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M866</accession>
    <name>D4M866_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretory pathway, component PulD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07200"/>
    <dbReference type="HOGENOM" id="CLU_1406956_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-449-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="193" mass="21581" checksum="DAB9875F51F69166" modified="2010-05-18" version="1">MHGIWREFDGAFRALEERGKGKALASPSVITIDGMEARVELTQDYPYISERDDAGNPTWSTQTVGPQMTMTPRVGRDGVINLALDLETGEVIQMITGSTGEQMPRTSKRHVTTNVRVRDGEPFVIGGLFSDNKSRTRNRIPILGQLPLLGELFTYRQDEHRKTQVVMLVVPYVLDTPDAAIEQEPLFPRTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M867</accession>
    <name>D4M867_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II secretory pathway, component PulD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_07210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07210"/>
    <dbReference type="HOGENOM" id="CLU_798665_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-450-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="347" mass="38944" checksum="D315C95FBE708F3E" modified="2010-05-18" version="1">MLLNYELYQLGASEVVFGLSGKALPDPEVSCESTRVRFLIRNTHVDRAEMSNHALVTPMISDMQINQVLDDVEIVMQTKAPLSVRSKRGSAPSNEFSYRMIAGVEEERIRREPLETRPKLEAPKPAGPFANKTKITLDLRDAELRDVFRMLGTHLKKNVIIDPSLPPALVTMTLKNVPLSEAFDYLMRTYDIAYHMVGKDTIVVGTQDGLSRLSGNEETRTFNIAYGDPSVIQGLLVNLTKLPADRVLVDPRLRALYVTSTPQKLMEVNNILQKMDRPGKQVMIYAKIFEFSDNATDEVETALNAVYNHWWLSYSGGAECAAATRTTIAWGAILRPIITRSSPFRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M883</accession>
    <name>D4M883_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase of chemotaxis methyl-accepting proteins</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07470"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2235"/>
    <dbReference type="HOGENOM" id="CLU_025854_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-467-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="268" mass="31024" checksum="A259FA7509506B38" modified="2010-05-18" version="1">MPEATQYDSPAYSAFKQKMQKIIGLDLNSYKEQIHRRIHMQMDRWGVKGNYDEYFNMIKNDSKRLREFLDYLTINVSEFFRNDSQWWKLRDKIIPELTQKRGNRRLKLWSAGCATGEEPYSLAILSAVCGLEASAPVLAMDIDQGALDIAQKGHYVKAQLVNAPKEYLAKYFTTKDGGESYDVNQEIKRRVAFKRFNMIDDSFGTGFDLILCRNVVIYFTNETKAALYQKFFNALAPGGYFLVGSTEQIFDYRKLGFEMAGPFLYTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M888</accession>
    <name>D4M888_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_07530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2242"/>
    <dbReference type="HOGENOM" id="CLU_1164533_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-473-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061527" evidence="2">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="238" mass="27012" checksum="27343401E139976E" modified="2010-05-18" version="1">MWKKLSTVLALSALLLAVGGEAWAALPRDYQEFKARYQKEGKTPEGAVKLYFEAVFCYINEATRAEGSKMVRYALHYDRPIEQSNNLSTFAERLRDPEMHHIFRGFAEGTSPENDYRMSPDNFNLVVGKKVQEQGYLRVFLRNSGADSPRVVWMKEFDGLWYMINNASTYVEVRPPKAFIDRTKNAHDADYDASPAPDPRKRDNDNTPSPSEGNASPEPTAPSDEGESTEDDEEVVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M890</accession>
    <name>D4M890_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bro-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07560"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2245"/>
    <dbReference type="HOGENOM" id="CLU_1183646_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-475-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003497">
        <property type="entry name" value="BRO_N_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51750">
        <property type="entry name" value="BRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bro-N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="234" mass="26936" checksum="89DB0832FA82CB9C" modified="2010-05-18" version="1">MADIKRDKLKIRNSTVDFLVFTKDAHEDGIEVRVQDHDVWLTQKAIAQLFDVDRSVVTKHLKNVYESGELSEDSTCANFAQVADNGKTYHYKFYSLSAIIAVGYRINSGRATQFRQWATKVLDTFTKQGYVLDKSRLINGQIFDEDYFDHLISEIQEIRASERRFYAANAARRFDPVFKEFYDRMIARGKHPKQALAAVGTKLLRVIHAVMTSQKPYNPQKLLPPSTRISQLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M892</accession>
    <name>D4M892_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate ABC transporter, permease protein PhnE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_07590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07590"/>
    <dbReference type="HOGENOM" id="CLU_064254_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-477-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="275" mass="29784" checksum="627B33DC308BD835" modified="2010-05-18" version="1">MKNSRIVSTKYRLVVNASSDGWLLLKRMLQVVAVVAVIIWSFYSIGFSLKELIQGLDGIVDIAGRMFPPKVSKWRGIVKPIVETINISVSGTFIAVLLSIPLGILAAKNISPNGFFYNLSRLLLNTIRTIPDMVFALIFVAAVGLGPLPGVLAIGVSSSGMLGKFLADSIEGTNQGKIDAIRATGANYMQVLVYGVIPQITAEFISLVLFRWEMNFRSSTVLGIVGAGGIGFDLITSIRLFQYKETTTILLGILLVVILVDFISNSIRNSLNADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E2</accession>
    <name>D4M8E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA or RNA helicases of superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_08380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32611">
        <property type="entry name" value="SbaSGP1ORF8370P"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.34"/>
    <dbReference type="HOGENOM" id="CLU_015668_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-535-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ResIII" evidence="2">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="906" mass="102111" checksum="4EA73E4883923520" modified="2010-05-18" version="1">MELKSYQQDVLADLSRFLDLLNETQNSREAYRRLWEERGVPVTDGGKSGMATYRVGLEGVPEVCLKVPTGGGKTFIAANAVRRVFNAMPARRVRAVAWLVPSDAILTQTHQALSTASHPYRQQLNLDFSGRVEVYTKQELLNGQNFNPVAVTEQLSVFVLSYDSFRTKNKEGRKAYQENGNLAPFARFYREQEAESGGASAEADDTALIQVIRRMNPMVIVDESHHAQSELSREMLANFNPCFVLELTATPKERSNVISFVDAVQLKREHMVKLPVIVYNRRTQGDVYADAISIREKLERAAASEKSGAYIRPIALFQAQPKNSTDNATYQKIRDTLVDAGIPEAQIAIKTADRDELRGVDLLSQDCPVRFIITVNALKEGWDCPFAYVLATVANRSSPVDVEQILGRVLRLPHARKNKSEVLNLSYVITSSADFYDTLERVVAGLNNAGFSSRDYRAEDSAPAAEADTQPSALQLHISPEADSMNPSGAHETPEANEDQDVDVVALKTRVAEAMKPDEDRSSEPEISDEIPGHDLLARALEQNAKYEAEMEKEEGGDGKNGGGLSRVPVEVREKMEYFAMREEYRETAQKLILPQFMIQKEMLLLSLDEGDYANYEIVEPEDLTVDFTLRNKDTMIDFSTMNTQIGGVDVGAKGEAPRAWKLSEADSLQFKKWFSSQPSTVRIAVCRQTIFEQLSSKINCISDVDLRKYVERVVENMDSDQLGDMEQSPFPYFRKIQEKINALLTEHRRKRFELLLNQGKIICRPSFRLREVISPVRHTAAIAKSLYTAEEDMNGYERDMVMELSGMDNLLWWHRNIAKREFQINGPLHAYPDFIAMTKSGKVLMIEAKGDHLENADSREKAWTGDKWASAAGKDFRYYMVFQQRQPGWPGTCNIEAFKAIARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E7</accession>
    <name>D4M8E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="9" type="ORF">SY1_08440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08440"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.41"/>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_0"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="272"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="510" mass="56150" checksum="393276E0F7ECD4C9" modified="2010-05-18" version="1">MSEKKYVAAIDQGTTSTRCMIFNKKGLPVCSDQMEHAQIYPHPGWVEHDPMEIWSRTQDVIRNALERGGISPAEIAAIGITNQRETTVVWDKATGRPIYNAIVWQCVRTQDFCAQWQKMPGWEQTVTGEGKVKDHTGLLINPYFSGTKIKWILDNVPGARERAERGELLFGNTDCWLIWNLTGGPNGGVHVTDVSNASRTLLMNIETLQWDKAMLDFLDVPEAMLPKIMPSSGVFGMTAKNGPFGAEIPVSGDLGDQQAALFGQACLKKGEAKNTYGTGCFMLMNIGEKPIQSMNGLLTTAFYSREQGKCVYALEGSIAIAGAAVQWLRDNLKLVDAAPDTEFFASKVEDSGGVYFVPAFSGLFAPHWDMTARGAIVGLTRYVQKSHIIRATLESICYQTRDVIDAMQKDSGVNLTSLKVDGGAVKNDLLMQMQADILGVEVVRPVVNETTALGAAYAAGLAVGFWKDENEIRANWAVDRKFASLSLPEKREKMYAGWKKAVEKSRGWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H3</accession>
    <name>D4M8H3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="7" type="ORF">SY1_08820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08820"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.79"/>
    <dbReference type="HOGENOM" id="CLU_144911_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="73" mass="8102" checksum="FBE5C186E3C6C967" modified="2010-05-18" version="1">MNISGNKKVIKTWSRRSTVVPQMIGHTIAVHNGRMHLPVYISENMVGHKLGEFAPTRKSARHAGQERAAKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J6</accession>
    <name>D4M8J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09240"/>
    <dbReference type="HOGENOM" id="CLU_2600972_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-589-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="79" mass="8601" checksum="EEFDCC3280E9ADEB" modified="2010-05-18" version="1">MKGKGLRDVALFGRVLSTGLVVAGYAFLGVWLSRWLDAEGYPGWLSVAAIPAALLFGLWQGWLFLTKIARRGPQDGKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K1</accession>
    <name>D4M8K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_09380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.139"/>
    <dbReference type="HOGENOM" id="CLU_1501408_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-594-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061019" evidence="2">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="179" mass="19869" checksum="FC8382F38A4D6B97" modified="2010-05-18" version="1">MKKLLLCALLMGLLAVTVSPALAWEKQKDLGQDHVKMKWYLLDYGVKDNVPFAIARKYYTNTSIKSQTVDLLMSKYNISPEVAGSLYFTEYGYEYTPDGKQFAVTYLRHYDMLGNEIYATVYDGSSDALKKVFANVDPKSTPGKGAAYALGKKPAAEKQPAAAKKAPAKRPAKKVKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K3</accession>
    <name>D4M8K3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hutI</name>
        <name evidence="6" type="ORF">SY1_09400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09400"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.141"/>
    <dbReference type="HOGENOM" id="CLU_041647_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="73"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="414" mass="44466" checksum="D8190ACC4DCC1FFE" modified="2010-05-18" version="1">MTLKLFRRARIYTPTLGAAPAAGAEQGRIRSVEDGAFLVEDGRFAAVGSASEVEGSLSGRTPDQEFDLGGAAVVPGLVDPHTHACFAARREAEFSMRLAGRPYLDILKAGGGILSSVRAVRAASEEELFSFSRDLLRRTLHYGTTTIEIKSGYGLDLDSELRMLRVIGRLGRETVQTVVPTFMGAHAVPEPFKSDPDGYVRLLTEEMLPAVAEQGIARFCDVFCEEGVFSIEQSRRILLRARELGLGLKIHADEVNDLGGASLAGELRTASAEHLLAASDEGIRAMARGGVVADLLPATAYSLRKPFARARKMIEEGVPVALATDLNPGSCYCESMAFVISLAVMEMGLTPEEALTGATLNAAWSLGMQQEVGCIERGRMADFLVLDGETPATFAYLSGARPIRSVWKLGERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K8</accession>
    <name>D4M8K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09460"/>
    <dbReference type="HOGENOM" id="CLU_045011_9_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-601-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="206" mass="22809" checksum="C3B9247B046D8962" modified="2010-05-18" version="1">MSTAAIDTVIFDIGGVLANFDWNGYVHRWVRDERAIQEINEALWGTGLWDELDRGVLSTESIVEGFIAGAPRREGEIRTLMEHVGGCVSRLDYAVPWIQSVKSTGRRVLFLSNYSRLIMDANPGVLDFLPALDGGVFSCDVKLLKPDRAIYAALCERYALTPGRCVFIDDLEPNVQGARDFGMQAIRFQSYEQAQEALSAMLGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q2</accession>
    <name>D4M8Q2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-sensing transcriptional pleiotropic repressor CodY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">codY</name>
        <name evidence="10" type="ORF">SY1_10150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CodY family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.218"/>
    <dbReference type="HOGENOM" id="CLU_089581_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00621">
        <property type="entry name" value="HTH_type_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014154">
        <property type="entry name" value="CodY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010312">
        <property type="entry name" value="GTP_sensing_CodY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013198">
        <property type="entry name" value="GTP_sensing_HTH_CodY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40062">
        <property type="entry name" value="PTHR40062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06018">
        <property type="entry name" value="CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08222">
        <property type="entry name" value="HTH_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011572">
        <property type="entry name" value="GTP_sensing_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CodY" evidence="8">
        <location>
            <begin position="49"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_CodY" evidence="9">
        <location>
            <begin position="242"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="308" mass="34375" checksum="5A3000BF4D26A8E6" modified="2010-05-18" version="1">MAKRTEKRRGTRKVEAEGTVDILNGTSVTESGWEAGPCSEAVTKAMEDILEKTRQVGRALQNRREGDLLDYDRLARLLSEFSTANVYIVDKIGNLLGHNWLPDYESKALSASMKNGVMPEEFVVRMNRCRDSEVHDEDAFLFDDDYAGERPEKHLMYVPIIGAAAERLGTVLLVRFRAPFLLRDLLLAEYLGTLVGIEILNERNRTIEERSRDRIAVQMAMRALSYSEVASMKHILAEIDGLEGVAIASKVADRVGVTRSVIVNALRKLESAGLIESRSLGMKGTYIKVLSPLFVEELGVATSPRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q4</accession>
    <name>D4M8Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent protease HslVU (ClpYQ), peptidase subunit</fullName>
            <ecNumber evidence="5">3.4.25.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_10170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.-" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10170"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.220"/>
    <dbReference type="HOGENOM" id="CLU_093872_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-655-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0915">Sodium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="180" mass="19192" checksum="6C101D05FC6F5BC5" modified="2010-05-18" version="1">MITLFTGTTIVCVRDGARVAMAGDGQVTLGSQIIKSGARKVRPLLGGKILTGFAGSTADAMTLLERFENCLEQEKGDLMKGAVKLVREWRMDKALRRLEAMMLAADRSMTLLLSGAGDILEPEGDVASIGSGSGYALAAGRALREATDWSPDRIARRAIELASEICIYTDSVVTLEVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q7</accession>
    <name>D4M8Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase./Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_10200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10200"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.223"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-658-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008595">
        <property type="entry name" value="DegS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05384">
        <property type="entry name" value="DegS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DegS" evidence="3">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="281"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="376" mass="41584" checksum="3DF4715F574F2F1F" modified="2010-05-18" version="1">MSDKVAVLEDRILQFIQQSLDELNSIRKEEASRLEKARSRITAMSIELKELASGIDSASREYSSLREKLVLYSKQGLIAEEKEAYDRASESMKLHALLEERYRNLTQRRDELQKEERALSRVVSKSESMGTRLRMVMNLVALPEAMPAAQAAEIVNDGALVTAFQIAEREARSFAQELHDGPTQSFSALGLTLEMAQELMSRGEYTEAAGELKLALSQLRGGLSEVRSLLFGLSPTGIDMGFEVPLKRLADQVKRSWGTELTWKLTGKLEEVPLLQRGNVFKTVHQAVVNAAKSGAPHVKVTIGNSRRTVRGLIIDDGKGFDVEKEKAAARERGSYGLQNMEERVTVQGGEFTVSSVIGKGTTIAFKVPLRTGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S7</accession>
    <name>D4M8S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_10670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10670"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.274"/>
    <dbReference type="HOGENOM" id="CLU_048702_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-678-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="265"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="452" mass="47038" checksum="E2153FE3A69D4678" modified="2010-05-18" version="1">MPWIWSVLMPHPPILVPEVGRGRESEAAETLAGLGRVAEAVRGRAPEVLLVLSPHQPCAPCALGLNAAPEPEGSFAAFGAPQVRMGFRSPAEDREVLGGFLTPRGIPISYRSLPDLSSDQGTMVPLHFLRRAWGGLPATLTASPTGLSPRGAFDMGRALADFDDGRSWALLASGDLSHRLIPSAPSGYAPEAGRAFDDAVLEALRRGSAAPIFALKLKTINEAGQCGLWSVLAMLGLMEALGGTARVLSYEGPFGVGYCTAAWDAPVPAPVRLARETVTRLLSGRPLPERGSDVCASPLWGRTAACFVSIKTSRGALRGCIGTLAPSQATLDREIIENAVAAATRDPRFPPMTAEELEGVRLSVDAVGSGARRGRGAAGPQALGRHRVEGLAARRAAAGPGGRGHRGAAGGDRGPKGRPRQPGGRRAPALRRDAVSRAGCGDGPPSDFVITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U0</accession>
    <name>D4M8U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10910"/>
    <dbReference type="HOGENOM" id="CLU_1684000_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-691-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061842" evidence="1">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="156" mass="16426" checksum="7A6C9BB98539A200" modified="2010-05-18" version="1">MKKVGFPLRVAAVVVLAASLAAEGTAAPQDAETALPASGDEAVMEVAEPAPVGVPEPKPSAVGFEIMGPNGERTVVPLDRLEVREATGSLEGLDGGQLTLAVGGRRYVCPLLAECAFADEKGQPMNRAAFAQRFLRRYVRVEMERTTGTVLSCRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V7</accession>
    <name>D4M8V7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 12">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">upp</name>
        <name evidence="13" type="ORF">SY1_11160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4 12"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11160"/>
    <dbReference type="HOGENOM" id="CLU_063684_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-708-MON"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="12">
        <location>
            <begin position="285"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="12">
        <location>
            <begin position="353"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="363" mass="39033" checksum="73CD5FACA1CA71E0" modified="2010-05-18" version="1">MKAAVGCDHAGFVLKRAVLDFLKERGIEVQDFGTFSEDRVDYPDFALEVARAVSLGDADCGVLLCGTGIGMAVAANKVSGVRASACNDVESARMAKAHNDLNVITLGGRFIKPEQVRGILDAWLATPFEGGRHVQRLNKIAMAEQTTLSVGSSGEGRVAIFNHPLVQHKVGIIRDKDTNVKEFRALVQEIAGLMVYEITRNLPLQEIEVETPVARTKAQTLAGKTIAVVPVLRAGLGMVDGILQLIPNAKVGHIGLYRDPDTLVPVEYYCKLPQDVEERDVFVLDPMLATGGSASAAISLIKERGGKKVSLVCLIAAPEGIERVHREHPDVDVFIASLDSHLNDHGYIVPGLGDAGDRLFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W5</accession>
    <name>D4M8W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_11320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11320"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.340"/>
    <dbReference type="HOGENOM" id="CLU_074521_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-716-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021269">
        <property type="entry name" value="DUF2848"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11010">
        <property type="entry name" value="DUF2848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="170" mass="18946" checksum="12F93120E0002963" modified="2010-05-18" version="1">MYWIEPERISAASSVWVVGNKTSGEGEVFLARCSQGNLHVTVASDHTDRALETVSVSKAKQIATKLVGAIFWRVDDVRDHWDEIELRVWNDGKIYQEGTLGQMLPPEALLELAEEDSPVKGGRISLFSGTLPVIGGGLVYGSRYVLSLRDPVLNRELWHEYAVQVLPDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y8</accession>
    <name>D4M8Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.406"/>
    <dbReference type="HOGENOM" id="CLU_137228_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-741-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026445">
        <property type="entry name" value="AlkhydPrxdase/COmuclacdeCOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04169">
        <property type="entry name" value="perox_w_seleSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="115" mass="12655" checksum="B2CB2431159918E2" modified="2010-05-18" version="1">MTTEKTNAYYDADDLNRFAEMGQCASPLWEKFSAYYGAVFEEGELTKREKALIALAVAHTVQCPYCIDAYTKSCLENGVNEAQMTEAVHVACAIRGGASLVHGLQMKNIVGRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z8</accession>
    <name>D4M8Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_11820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11820"/>
    <dbReference type="HOGENOM" id="CLU_1114972_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-751-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="287" mass="32208" checksum="699FB17D3DB936D1" modified="2010-05-18" version="1">MNLFESLEEQRREAYVRAVLRASGTDDVVGFIGSRVPLELLNALGLMVLPVYGVDGEILKYSREKGLCPVIDATLTYARTDRCPLIHSSRLIVVDDGCPIMAREVSRLPGKEVHVYRTEDPMRLEHLMEKLERVYGRGLDDGALDAATADSRRLTELLFNLKYHSGLDGRSVYVLEYYLNFLSVPERFEVLRQASGAAEFSAAPVDFLPVRVQSGAGIYRQLDRQLSGSLYRILEGEGCQGCVQEVVTGEGRDFLRAKYDRKRKSVAVYDYVYPNCPFGTGTEIGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M911</accession>
    <name>D4M911_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type metal ion transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_11980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11980"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.433"/>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-764-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="25"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="227" mass="24787" checksum="2E2DA5E7C9099230" modified="2010-05-18" version="1">MEAFTRAFQNSNLMRYLPTAIIPAIGETLVMVTISFVLSVIFGVMFGIILVMTDKSGLSPHPAFHAILERITDITRSFPMMILIVAIAPVTRFFIGTRIGVKAAIFAITLGSTPFAVRLTENALNTVDPQLIRMAQSIGATKLQIVFKVMLVEALPTLISNFTIMAINILNTSAMAGAVGAGGLGAVALTYGYQRFDYLIMYFIVIILILLVLVIQTIGSRLYEYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M923</accession>
    <name>D4M923_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_12120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12120"/>
    <dbReference type="HOGENOM" id="CLU_031290_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-776-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030821">
        <property type="entry name" value="Synergist_CTERM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04564">
        <property type="entry name" value="Synergist_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061847" evidence="3">
        <location>
            <begin position="23"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="678" mass="72136" checksum="8DB1507DF459B265" modified="2010-05-18" version="1">MRKRFFAILALILALAFPVAPAGAELIFTRQDNSYANTALGIVLGDGVPIHPLVSNMGGNQGQGIYPFVNADGNFRVAITLYTLNGTDVINIHDPGPKENWKIPQTWNRPQEAGTSLHNTRILVPSGGYLYGTAYDIPTINRVSTRGDQYTEDKTYLYTPSSSGNKAHGEGLVPYGDALYAIFTEGHDVWNIAGVGYAPNRLVKLDKDLNVLANKPMLGKNLDGFTPGAYIRQGNLLYVATLGGVQPFGNTYNPDSCVEIVNLDTMEVSAPVTARRMKEKDPTFSHMFGAVASAWGKIYVQATQWVSEEEYKPGYSIRVYETTAERLAAGDLGTLLRDFKGKYGYRMGLVYDPERNYLWAGVGYSLWRYDGTNWREFDANALGGNISAYTAISIQTGPVIPPSPSPSPSPSPSPSPSPSPSPTPQPGQPESGIVPSLPGGSPEGIQAVKPEYFAASGQAEELTKAAEALSRTGLTRDDLRADSDSGVVKLAPRVAREVAKKVLPASETTATVKLLPVLTARLNKAGGVAAAGVALTVTDPKGKRGADVKLLKVTGPDKGVLLTWAARPADFADGRFTVLDDKGNIVEDLKPYIPYVLTLFIRDGGPLDLDGAADGKVVDPAAILTVEASGTPAPEPKPDTNPGQPDKGKGGGGGCDAGFLLGWLLLAAAIPVVLRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M928</accession>
    <name>D4M928_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">The GLUG motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_12180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12180"/>
    <dbReference type="HOGENOM" id="CLU_363982_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-781-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030821">
        <property type="entry name" value="Synergist_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04564">
        <property type="entry name" value="Synergist_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061029" evidence="2">
        <location>
            <begin position="28"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="957" mass="97858" checksum="DA46027B8D93CEC4" modified="2010-05-18" version="1">MQTMKARAFCTAFLLAFLVLFSPAANAANWIDSADVSWYDEGKSEFTLTSEAQFAGLAKLTLEGKSFKDKTVSLGADLDLGSKEWTAVGAFEGLFDGRNRSITLGTGNTTALFSDLLKGGILRNLHLSGTVNLAPKGASPVMQEGFRWADGTLLGVNRGIVENCSFKGKVRYVGSEGVVRALGGLVGCNPQRLPGNPSSIIRGCRVSGALEMAPEAGSASSGVPLVQVLIGGIAGINLGDIEDSVFEGMLNRTMGGGSIVAGGIAGGLDGCFDILSGGSYRNCFASFDMKSSVPMQEAAMMTAMGTPDTTCLGGIVGRLYDQTEIENCRARAELEYQCGIDNVCAGGILGFGFAKIINGVFEGNVTIAGTPMAPLIPEASLVRAYGGVAGLGAGLICNSFAKGTVTGPDGAVGGIAGYAFGKVENCSAACNVSSEGDNANVGALVGNNQDAQGAVSNCRWVSGLGADKAIGAGDKLDSTDVVAAESALPATSVAMIPWIGLTENKTASVKAEVYPLDAFNGETVSLKISPLDENILKVESDHAGMAVVRGVKKGTSGLKLSCNGLLGDTSYYPASFVTVRLIRLASLSLSPKVIELAQKDQSAEIHMAIAPDAGAVSYLPKWTFSVLEGTSAAADDIELMPTADGLGAAVTLVRPVSGAKYRVLAEAVDGSGLSDDVIVMVKYNPPAPVSPDVSPDVPAPTSPDVPAPTSPDIEPGEPEVGIAPRLPDGVPAGVGASKPAFFGGSEAAALKNAAAALSDTGLEAKDLAFDPDTGIVRLQSRVAREVARKVLPEGATVKRVRTLPVLSATLPQGANVAAVGLELTGRDLMAKKASEVELLKATGPDTGALLKWSGKPEEFGDGRFTVLDGSGRGVDELQPRSRYVLTVFIGDGGKYDLDGEANGKVVDPLALLSLKGGSAPGPQPGPDGKDGGGGGCNAGLGWLLLLAAVVPVALRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M960</accession>
    <name>D4M960_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="4" type="ORF">SY1_12800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12800"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.512"/>
    <dbReference type="HOGENOM" id="CLU_100590_5_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="89" mass="10005" checksum="0761DD0D8E20EE2D" modified="2010-05-18" version="1">MAVRIRLSRLGKKKAPYYRLVVADSHSPRDGKFIELIGTYNPMTDPAAVAINEDRALYWLSVGALPSDTARGLLKKQGIWEKFESKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M966</accession>
    <name>D4M966_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane proteins related to metalloendopeptidases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_12940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12940"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.524"/>
    <dbReference type="HOGENOM" id="CLU_663510_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-819-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="310"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="414" mass="43402" checksum="4375CED8D40ACA2F" modified="2010-05-18" version="1">MSTNRKRKRGLFLAGALYAAAALLVLLTCCVREACAARWESLTLSDDVAGGLESLDKFCLLHDLSSADVLWANNCTVSDLAPGKVLYLPKSRTDVLSLWQHQGAWQPKALVKTTSAAVAERARGASGVPPVSASLRPTPPAPQATGTKPAPPPEGGKTSPVAPQGAPNKAPAPPSLKDAVAGRPAQDGKRETPATGKVTKDKNADGKDGSGKKQAKAAPLLLLSPDGDSGTGPMRLVISGDSVAIVRLPKSAAPRTPSMADLNRSFLFPTFPETPPSEDAHPSVGLRGKKMLWPVNGAVSSGFGKRGSRKHDGIDIPMPAGTVIRVAKDGVVARTGTNKTPCYSGYGNFVLVNHGNGLQTLYAHCQKVTVKVGQKLQEGQIIANVGRTGRATTNHLHFEVRVNGKPVNPVLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M969</accession>
    <name>D4M969_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12980"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.528"/>
    <dbReference type="HOGENOM" id="CLU_038686_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-823-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="259" mass="29345" checksum="FC12E1EAA644E3C0" modified="2010-05-18" version="1">MEAFDISVEGFSGPLDLLCSLVESRQMEASRIKVRQLVRIYGVYLARTKRASVETIAEFFYMAAGLILSKTRSLLPGAEPGPEEEVEVDEEALMETLVRYRPYRVASHWLWGRLEEQSRCFRRPAQGAAEDGGGEALDLEYDIGDLYFLARVWWGVFERHDRERSRERERLLEEEAADWDGFAEAAPDEALIEDRIAELDGRLAREGTLFLSALCRAAHSVKLLVVTLLALLEMCRMGRVRIEQEELFADVKVLAGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M973</accession>
    <name>D4M973_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">SY1_13080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.537"/>
    <dbReference type="HOGENOM" id="CLU_001715_1_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="186" mass="21289" checksum="C79BCF9B89038B02" modified="2010-05-18" version="1">MRRGRLFILSGPSGVGKGTLRERALKDVEGLIYSISCTTRSPRPGERDGVEYRFVSEADFKRRVQEGLFLEHARVHDACYGTLRADVERELDAGNDVLLEIDVQGAKQVRSRLPDAISIFVAPPSLEELERRLRNRQTESDDELRHRLANAEMEMEQEGTYDRILVNDDLDDASAELRRLILSYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M981</accession>
    <name>D4M981_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_13190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13190"/>
    <dbReference type="HOGENOM" id="CLU_2287425_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-836-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="101" mass="11458" checksum="48A44117E44C6ACD" modified="2010-05-18" version="1">MTNALGGVLGVQQYVLLFLWGVLLWGVCREVRDFIGMPRRGRARRHRWREAKLPVPAPVWQATRPVGAGGGACRRGKGKRSRIPERKGALRLDVDRSRFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M995</accession>
    <name>D4M995_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemotaxis signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_13410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13410"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.577"/>
    <dbReference type="HOGENOM" id="CLU_048995_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-851-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024181">
        <property type="entry name" value="Chemotax_regulator_CheV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002867">
        <property type="entry name" value="CheV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="181"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="311" mass="34678" checksum="A1E9512119EF33A4" modified="2010-05-18" version="1">MQEVKKVTTEVGTNEWQLVVFVLGDQSFAINVDKTREILRWPGCRAIPDAPAALIGITSVRGEVLPMVDLRVFLGIQPVTAIEQSKVIIAEFNEVKLGFVVDAVERIYRIKSEDLDSTMTGKYLGDWILYVIKRDSRNVLLLDYEAIVQTISPQLVIQHNAADSAKTRAMLEDVGHPADYRIIVAEDSPLIRKQVEDALTASGFTNLKICPDGKVAYDAIVKDREDCDLLITDVEMPRLDGLTLTRRIKENLETKNIPVVVFSSIMANDIKNKAASVGANYQVTKPEINQLVECVVKVIKEKEEKRVAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B5</accession>
    <name>D4M9B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase family associated with various cellular activities (AAA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_13730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13730"/>
    <dbReference type="HOGENOM" id="CLU_1022802_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-871-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="48"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="276" mass="31362" checksum="D9D2B80DAD174180" modified="2010-05-18" version="1">MSEMRLKVLPPNCRKFGKELSDPDNFQQGLLVDEKLLERLTGILMQSDHNNIALVGDPGVGKTATVQALGQFLVRTNRSFRLAEIDLNLLFAECPTYSEQGLRLKHLFREAEEHSIVLFFDEGHRLCNDHGSNSVANIVKPLVTNPRLQLILATTCEEYQRYIATDRAFRRRFRELEVAEPNPQDTARILESVAKARYRDIAFEDGVFAFIAELSQSIMEERYNPDKSLEVLDAASGRHRLLNPDAALNVDEVKTTVREQFSEAEPRVGFRGHHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D3</accession>
    <name>D4M9D3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_14090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14090"/>
    <dbReference type="HOGENOM" id="CLU_042663_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-889-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="266" mass="28647" checksum="A444237140236586" modified="2010-05-18" version="1">MLDRRQVRERAHGLTALILGLFLLGVGASLGISKTAADLLSGMLSIPEYPAVLLRETIRDWLSWGRSRSAIQAEIEALRGENAELRVLNATLANERIRVELSALEARKDVARITLRAPMSWWNEIRIDKGEGDGVIVGLPVFHNGYLAGRISSVSLLSSWVELLTSPSLMIPVVVEETRELGVVMGNGSGSVFLNYIPAGRGSMKGMKVSTALIGEQLPPGLPIGVIAEELETTPDGYATYRIAPGADFSKLYSVSLLVGPEGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E0</accession>
    <name>D4M9E0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">SY1_14350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.675"/>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="73" mass="7981" checksum="3D8D7EF2DC6610F3" modified="2010-05-18" version="1">MIMAKFCQCCGRGPASGNAVSHSNRHTRRRWLVNLQSVRIDAGDGTTFKVRVCTKCLRSGFVRRAMAAAPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E4</accession>
    <name>D4M9E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_14480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.686"/>
    <dbReference type="HOGENOM" id="CLU_023982_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-900-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="314" mass="33969" checksum="47C795B9B4FB3AD6" modified="2010-05-18" version="1">MKRATLWGAAFFCLSLVLQYVWLRVQRRVSLTQAQKSYGVGIDVEVKAATPSMGGAVFLVLALLGLASTWSGESLTFWSLPLAGGFIGLLDDGLKFFSRSSEGLRSLTKLKVQLVVCGLWVLLVFLKGRAGLWPGLELGWPLLAPLTFIGCVGMLNAVNITDGLDGLAGGCAMISLTALPFLIPASEFNVTTVSMLFFMTAGFMFFNLRPARTFMGDTGAHFLGGALAGLCVTNGRLLALIPVGFLFGIEMLTSAIQIFTIRKLNRRVFLMAPLHHHFQRMGWDESLVTARFWLVQAVGAAWLSLLLLCVGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H3</accession>
    <name>D4M9H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_14920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14920"/>
    <dbReference type="HOGENOM" id="CLU_2069685_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-929-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="118" mass="13016" checksum="CCECBA55D710FA9A" modified="2010-05-18" version="1">MMRMGDVSLRRVGTVLLVALVAAGAFALRAEAVTEIPMLEVTGTLERVEPVEGGELLVLKVDGKEASGPLFSDCHFLDERGTLIPKEEFLRRYMKRYVTAELSEAEGLIYVCRVKTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H8</accession>
    <name>D4M9H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein insertase, YidC/Oxa1 family, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_15000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.759"/>
    <dbReference type="HOGENOM" id="CLU_036138_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-935-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="259" mass="29399" checksum="E59DDFF1D433BF88" modified="2010-05-18" version="1">MWLLETLYGVTNSWGLAIILLTVIVRIAMHPLTQKQMVSMQRMQKLQPRIKVLQNKYGDDKETLNREMMALYKEEKISPAAGCLPLLIQLPIFILLYRVLYNNDFAGATFLTVHLDGSVLTTMADALNLVDKAGVPIPRDQLGVVMVFFSSFTNLPLLFSNVGMWLPNMILLILIAFLTWYQQHLSSAGNPQMAMMSWFMPLLLTFICIGLQGGVLLYWGVSSLMGVVHQLRVMRKTDEEMRQKPVLLQEKPAKEKPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9J2</accession>
    <name>D4M9J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15220"/>
    <dbReference type="HOGENOM" id="CLU_005854_7_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-949-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061852" evidence="1">
        <location>
            <begin position="25"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="2">
        <location>
            <begin position="324"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="543" mass="59476" checksum="166926855EED17E1" modified="2010-05-18" version="1">MRQKFFAALCALCVCLLSGTLAQAKDGTMTLLTLNRLSGQLLPIVTRVNKGTVAIGGLAHAAGVVQKVRETEPNAILVVNGGSVYGPMWRYFGGLPEFTSLNLAGVQVGTIGMRELDFGWEHLKGALQYIRFPLVLSNVDVLDPEAAPFFKKNVIVQAGDLKVGFFSMLSPQILTATTQKVDELQLSKAGLVETAKAMVADLRAQEADIIVMLSNLTDLENQHTLEQVSGIHAVYGRTLGLTEDPLPGFVRGPDDWLTTMLWSGTVARFVGRLDLTTRDGRITEDSVKWQLLSVTPKVEPNAAILNLATQYEEKLNKKLETIMGSFNVPVDARKEVLRSGESPIGNFLADAMRTRFRTDVSLANAGNIRGNKIFREGKFSEKTLQELFPYQSRVDILTVSGDVLRKAMEISASALAAHGDGYDTSFRTPTGGFLQVSGLRVVYDLKNPPTTFNEDGLVAQWGSRLADLRVEKDGAWEPVEDSAYYTVAISSWLSEGGDRYYLFKGLPSQDSGLLDYEVLVGYIKTFPDGALKLAPDQRITVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M4</accession>
    <name>D4M9M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15800"/>
    <dbReference type="HOGENOM" id="CLU_2395440_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-981-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="93" mass="9835" checksum="3E04D9990D474654" modified="2010-05-18" version="1">MLRSCSCIDALAAFVAVLAVALFVAAAWWFVALGFGLLAAVLLGALAFCAFGVLVALTAPLWGLALGLLYILVLFLLMPFYHLATCFKTHKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q4</accession>
    <name>D4M9Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_16210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16210"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.891"/>
    <dbReference type="HOGENOM" id="CLU_076542_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1011-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="100"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="263" mass="28286" checksum="456DA8128DD0365E" modified="2010-05-18" version="1">MKPNYKNWVPKGLLVALAVVTAVVLLFFLALGVLGTGVSDTARGVLAVVLGLASAACLVFLALGTALYRAFDYNGKRQLARAIVEGVAQYVRLPDGGCGLDVGCGSGALTIACAKRNPEGSMTGIDLWGITYASYNKKLCEDNALAEGVGNVRFLQGNAVKLDFPDESFDAVTSNYCYHNIVGVNRQDVLLETLRVLKKGGTFALHDLMSRARYGDMQAFVERLRGMGYQEVQIIDTTQGLFMSPREAKFLFLGGSTLLVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S1</accession>
    <name>D4M9S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16440"/>
    <dbReference type="HOGENOM" id="CLU_132073_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1028-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="148" mass="16541" checksum="5E885DF9A0E9CF9B" modified="2010-05-18" version="1">MNKTVLITNNRDLCASVRCGRFVDGSSLDVLVAVRNSIHLGSILLTHPLCGNLRPYHQPFRSILLEERPGALVDLESLSMIEKAVGVYEACRERMIVPSALDEGRRADYAFIDSELMKESLERYGQLRREAALHPASLLLHGEPSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T6</accession>
    <name>D4M9T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16740"/>
    <dbReference type="HOGENOM" id="CLU_2142248_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1043-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061761" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="112" mass="11465" checksum="135911C76C8E6C8A" modified="2010-05-18" version="1">MRAKGMKIALLSAALATASVRALVPYAPPAVINESDCPSAFAMDVRPRRNPGSVGSVTADGYPVLLRPSGAAWYVMPHGMPLPDPVVLRGYPGADFSPGPGPAAAPLPAPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X1</accession>
    <name>D4M9X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, YhgA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1016"/>
    <dbReference type="HOGENOM" id="CLU_066636_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1079-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="76"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="298" mass="33513" checksum="A7D79BC9342703A2" modified="2010-05-18" version="1">MAERDMTEKHLEGYNDVFADIVNVLLFNGERRVRPEDLQDARSRTLYKADGKLHEQERDVSKLWVSKGAVISLIGFENQTKVDRDMVLRVLGYEGADYRGQLSAGRGLYPVVTLVLYFGEAPWTGPRTLFERVSVAEGLRPFVNDYRVNVFEVPRLTAEQVGQFRSDFRIVADYFVQMGRDGDYVPPRQTIEHVDAVLKLLSALTQDHRFEDTQNEFRKGEDVTMLSVLDKVEARGVALGEARGVALGEARGVALGEARGIASTARRMLMRGVPLDQVADFTGLSLGEVEALRREMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z8</accession>
    <name>D4M9Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation and spore germination</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_18030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18030"/>
    <dbReference type="HOGENOM" id="CLU_084424_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1106-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="3">
        <location>
            <begin position="137"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="236" mass="26466" checksum="38D7BBABCEE652B3" modified="2010-05-18" version="1">MVRRSPYRDEYEDEIGRRPKRPRRDQRPTQRRKDAPLMLRVLSWLGVILLCFVAGYLGTSWVMDALNEKLLLKPENRVENQSDLAKLNAAVERDREAAAARSGNVQQVSLKLYSVKDGRIAEPVRKSFVSRLKEDNMAEAVKSVLALSGVPGADKVSVLHVFRSAETAYLDLSSAFVSALASMGQRESLLLLTAIVRTMEENFEPVVQVRFLIDSRSPNPGGPVDLTVVWKMPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA19</accession>
    <name>D4MA19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTPase subunit of restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32615">
        <property type="entry name" value="SbaSGP1McrBCP"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1118"/>
    <dbReference type="HOGENOM" id="CLU_008747_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1127-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="414"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="666" mass="77548" checksum="D4F3F35D99B08C34" modified="2010-05-18" version="1">MFDPFRLKDILVEYKRNFVSKQWENEKYKWEAVKWFQDNWDVNAVDFPEMLSRSLDKTLNLLTSANYFPKGMIVDFARSAHEEVRSMFIALFDESKDVFERMDAFSAHSSILLKEYGSEDAQHYQYENSISTYLWLRYPDKYYIYKFSEAKAVANELNSNYRFKKGAYADNIRNFLRLYDEISLALKEDTELVNLFESQLTETCYSDPELKTLTIDVGFYISRYYSQKDAAAAKPVKWYGSDYDSGLTVDDWSKLLEDETVFTTSALEIMKRIKDYGGMASCTQLAMKYGETKNFYNAGSFGLAKRICEATGISPNTRDNGSTRWWTVLYVGRNADKNEEGSFVWKLRDELSAALDKADLSNVKLYVTAASGEKYPVTVVAPINAYTKSDFLDEVYMTEKRYENLVSVLQNKKNIILQGAPGVGKTFAARRLAWSMMGEEDDSRIEFVQFHQNYSYEDFMMGYKPVEDGFELKYGIFYRFCEKAANRLDKDFFFIIDEINRGNMSKIFGELLLLIEKDYRGTKATLAYNGLPFSVPKNLYIIGMMNTADRSLAMIDYALRRRFSFFEMEPGFDSDGFIQYQNSLNNETLNELVSKVKELNREISLDRSLGKGFCVGHSYFCGRDVCTRDWLYSIVDYDILPMLSEYWFDDVNKLRHWENILLGVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA26</accession>
    <name>D4MA26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type DNA-binding domain-containing proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18700"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1131"/>
    <dbReference type="HOGENOM" id="CLU_075551_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1134-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="193"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="307" mass="34925" checksum="006FD975B91EC27B" modified="2010-05-18" version="1">MKDNLSEKVTRPWVPFREFIGNNPYLEFFRTNNLTVIVSRRPVCMLPNSYRHESVQFFIALSPVRGGTRDGHPIFVPAGSIYPVNGSQPHAVTEPIPNVSFISLYFRYAFFQKMCRTLRGSPDTVFENDLIPYDPELKALMRAFFIEYGGGRRGSPGIGSGVMVDCIVIQLAVCLIRRLRFSAAATEQRVPSDAELDRAVEHLSERSDPCPLSEVSQIVHVNKFTALRKFRAHTGMTPRQFQMLIRIHRAMDILKDPRCTIAEVGKLCGFPNPSHFARVFRQKTGLSPTEYRRKSLNEVPRTSRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA33</accession>
    <name>D4MA33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_18790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18790"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1144"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1141-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="346"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="390"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="611" mass="66581" checksum="A177FD1B275C20F8" modified="2010-05-18" version="1">MEKKKRSGIARLLEIAGQRRGLVTLSCALSAVSAALMLVPFLNVYFILGELLQHGLSPANSGFFVRQGAVAFGAMALGFVVRYASLMASHVAAFRILYGIRLGLARHIGRLPLGFLSGTTIGAVKKTMEQNVEDIELFVAHRIPEVVDAATTVLILAGALFFLSVPLALTCVGAFVAALAFQGSLWFGKKGRDNLKAYYDALERVNASAVQYVRGMQIVKVFGRTVQSFRSFYADLQDYGKLCIQFTNAFQNGYILFRVVANSFLALLLPVGLLLLRDDPAGQAFALTFLFFVVMAPGAAAPMTSLAMLAMQGRQIDEGVERIEAVMDRKPVPEPQKPRRPDRFDVEFRDVSFSYDAEGPENANAVSTRARALSSVSFHAEEGRVTALVGPSGGGKSTVASLIPRFWDVREGEGQILIGGVDVRDIPNEALMDTVSFVFQDNFLFFDSVMNNIRIGRPDATDDEVVAAARAAQCHEFIERLPNGYDTLIGSGGVYLSGGEEQRVCIARAVLKNAPILVLDEATAFADPENEFEIQKALTELIKGKTVLVIAHRLSSIRKADQILVLNEGRLAERGRHEELLMADGLYARMWRAYVGAGSWKLGGNRKGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA38</accession>
    <name>D4MA38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18900"/>
    <dbReference type="HOGENOM" id="CLU_942519_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1146-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="295" mass="32966" checksum="DBA241D248E835EC" modified="2010-05-18" version="1">MWGGMTKMTALEFLLTAAAAVVLLCLRGDGSSVSAENRQPDETTREEVPERCPARHSPVASSQPFGMSFSSKVVREMEAPEEKDHRLRPFHVLNPEGELFMVDTGAEGPFYGPVWTRVLDAYEKGEFLRARVAFRKTSRQNEFSGYVLSLDGLPVFLPRSKSFYFYDEKKDAAKRCIAVKIESIYPNGPRIGNVVVNAKPAWDLVRKGLYRLAPGIEVHALAMDIDQGGGVEEGHLVFPAPEHRRILVPLPEARRLARQAGQSVPDDFLTGLYWRLRLIAGDESAWQAEPLEVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA86</accession>
    <name>D4MA86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_19540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19540"/>
    <dbReference type="HOGENOM" id="CLU_3418930_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1195-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="25" mass="2821" checksum="57B29E7DC4C41EBE" modified="2010-05-18" version="1">MEPLGYPTDWLKAVGFGDQDVEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA91</accession>
    <name>D4MA91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase involved in DNA replication initiation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_19660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19660"/>
    <dbReference type="HOGENOM" id="CLU_026910_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1200-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_DnaA_C" evidence="8">
        <location>
            <begin position="66"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="156" mass="17840" checksum="4D93756EED163176" modified="2010-05-18" version="1">MLRGCDLPDEVVHFLAQHIPSNIRDLEGALNRVIMSSELYGEPVTIERSSEWLKDVLRMDVKAPVTVEDIQSVVAEYFSMSPEELTSSKRTAELAMARQIAMFLCCEMTETSLLRIAHAFRKKDHTTVIHARKKISELVKTDQEVRRAVDNLKNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA7</accession>
    <name>D4MAA7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="6" type="ORF">SY1_20000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1264"/>
    <dbReference type="HOGENOM" id="CLU_169643_2_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="66" mass="7724" checksum="B041726EFA8864B5" modified="2010-05-18" version="1">MPKMKLKSHSGAKKRFFRTASGKLAYRKCGRSHIMVHKGAKRMRTLRKTGYVTETLMEQMNHLLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB2</accession>
    <name>D4MAB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FOG: GGDEF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_20120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20120"/>
    <dbReference type="HOGENOM" id="CLU_743465_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1220-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="200"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="372" mass="39982" checksum="9D73E1EC32172BBE" modified="2010-05-18" version="1">MDRNGSLFQWLTLPPAVAVATVFVAGAMGSPLSAEPVNPSFWGMTGLLFVVLSALYGLFIVHGFGVGLLPLQLVAQGILLCPLALSRGARMFQWVGVIMAVCGAVALVNLYHYRRRRPGPAAPKGTDETEVRLPVPFVVTDGEGVVESVSSGMLEAAQLPLEAVKGQSVAVLLTPGDATATLGGRTWDVIQRPMEDDRYYFQLNERVAAPAPEAGATALTDPVTGLQTFRYAMMRLDEELYRTRRYGHPLTVLLIRLVFSAAAERDPDSREAFVAYGALIRKSLRTSDVAAPSGDRELMLMLPECPAASAEAVVKKMLGLLGTLNQDHRSLSEVTALHVAASFESTDDVPNARSLVDGLIASMARKYTLNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB7</accession>
    <name>D4MAB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20280"/>
    <dbReference type="HOGENOM" id="CLU_686542_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1225-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030821">
        <property type="entry name" value="Synergist_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04564">
        <property type="entry name" value="Synergist_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061865" evidence="1">
        <location>
            <begin position="20"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="401" mass="41454" checksum="DE8DC870FB250BC9" modified="2010-05-18" version="1">MKKLSCAFLVALALCGAAAANVAYTTVDAGYTGAIGVIDEALQAGRAVGSLRGDALGASFPQGGRRLYVFLEHDHTTGDKAAVYNPASWDVPVANRTWTNAMNVHGLAAYGGNLYAAAHEGGAVIQVNTSSYTATGRYYICTAAPAGYVPHAERVLAAGNVIYALFTATRGSYPGYTYASSVLVGLDSALNKELVRYEGLGRNAVDMAKIDAGRIAVACRGTGGVQVVNLNAADGADWLALEVVSADDGTALGSVTAVCEDGGGGFYFIAERRDGAAARPTLTLYRWTGSARYPVKVYEAKGVAGYACQLVRDTAYRNRVFAVMGDRVAVLEADGRHVKTIGSAELGGNPTSIAVIDRPAGDGGKDKSSSGGGCGALDLGGLALVLPLLALRRRSTPQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC9</accession>
    <name>D4MAC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20500"/>
    <dbReference type="HOGENOM" id="CLU_2584661_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1237-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="80" mass="9013" checksum="320A749C69DBEC8F" modified="2010-05-18" version="1">MTQERITVSRWRVRIHDWECRRTPRRGGRKATYAYDGLYRLTGETVTENGTTSVKTYAYDAAEDLAVGDSIQALSGDVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD7</accession>
    <name>D4MAD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20670"/>
    <dbReference type="HOGENOM" id="CLU_1812981_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1245-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="142" mass="16390" checksum="83D6CAC493FC7721" modified="2010-05-18" version="1">MLVKYSRPFKSYPFNVISLSKSFSEQLVKEKVYLVIEASFDFRINKYSEVLGAFYRIIDEGGTPAIYNADGFEIVSGNLDGYYLAQNRNDYIIMTHKLIFEANPDKFWDTYFESTTNEGKNLLKSVIKDLASKENIPEPILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE1</accession>
    <name>D4MAE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-binding proteins-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_20730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1332"/>
    <dbReference type="HOGENOM" id="CLU_075053_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1249-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="212" mass="23383" checksum="A6A93051B592E379" modified="2010-05-18" version="1">MDAAEVQTALEALCAHERRYARGETLLRAGETTDSMGLVLEGSVTIKSDDVWGNRTILSHVGPGQFFAETYAFLKGSVLLVDVCANEDCRVLFFRLDGLQAPSGHAAPWQLRLLSNLLTISSRKNLALSGRSFHTSPKTIRGKVLAYLHSVSIQRRSGEFDLPFDRQQLADYLSVERTALSKELGKMRDAGLIAFHRNHFVLLSGDAGPNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE3</accession>
    <name>D4MAE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sel1 repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1337"/>
    <dbReference type="HOGENOM" id="CLU_000288_36_7_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1251-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="215" mass="22775" checksum="6E0A4CBCE17592DD" modified="2010-05-18" version="1">MEKDPMEDDLFAEPSGDGGNEAPDLEALLAAAGGGDAGAQYRLGRMFSNGRGVAQDAAEAARWYRAAAEQGEPNAQLCLGVLYENGQGVGRDVAEAARWYRAAAEGGSARAQFYLADMYVYGCGVAPDEEQAARWYRASAEGGFMAAQCRLGWMSAHGRGAPQDDREAVRWWRLASEQGDPEATLCFSAMCASGRGIDQDGGLPQCGAGTEEGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF0</accession>
    <name>D4MAF0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_20870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1346"/>
    <dbReference type="HOGENOM" id="CLU_068847_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1258-MON"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="172"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="337" mass="36734" checksum="92971B9BFE1F026C" modified="2010-05-18" version="1">MKLLKTEDAVGQVLCHDVTQIIPGLFKGPVFRKGHIIREEDIPVLLDVGKENIYIWEMDEGMMHENEAAEVLYDICRGRYMHQGEISEGKIEAIADIDGLLKVDKKRLNIVNSQGEMMIAARHGNFPVKAGDKLAGMRIIPLVIERAKMGKARREAGGAILNVLPFTAKRVGIVTTGSEIYNHRIEDKFTPVVIQKVEEYGGIVIGQRLSGDDVDAETGFIREFLEAGADMVLCTGGMSVDPDDRTPLAIRTASDHVISYGAPVLPGAMFMLAYKGNVPIVGLPGCVMYAKRTIFDLILPRLMANDPVTSDEIDSLGEGGLCLGCSVCVFPNCGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH0</accession>
    <name>D4MAH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted nucleoside-diphosphate sugar epimerases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_21150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1374"/>
    <dbReference type="HOGENOM" id="CLU_1945610_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1278-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="129" mass="14420" checksum="08BE696D67EF9271" modified="2010-05-18" version="1">MLIPEAVSLVIQAGALGKGGELFVLDMGEPVVITEMAELLIRLYGYEPYRDIPIVFTGVRPGEKLEEELFYDPGSVHPTRHPKIFTSPLGGAMDARSFNSLLDEAVRRPQEALTLLHRLVPEYAEWERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH1</accession>
    <name>D4MAH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_21180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21180"/>
    <dbReference type="HOGENOM" id="CLU_149135_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1279-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="143" mass="16007" checksum="0FB3E4F9229B27D6" modified="2010-05-18" version="1">MPMQIGLDELISMLLARMDGLTMDSENQKSRFNIMFRILYRKGFFDESDVLDAVREEHGILHSLGMLKEMPDEKALKAVADGLMLWIKGDVEAIKKSIEDYDKRLKEAMSHQKSKIDVAPAAVLDQLDRLGGGSQGGGKKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH4</accession>
    <name>D4MAH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_21240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21240"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_8_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1283-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="229" mass="25286" checksum="F39E9EF6B79FC616" modified="2010-05-18" version="1">MIKIVVADDHKLFRDGLRKILELEPDIKVVGEGADGEEALELLRQHRPDVILFDINMPQMDGVQLAREIKARGIKAASVAVSAYDDEDCLATLSAEGVKGFVLKSSGRSELIAAIRAACRGEPYVDPKVAGKLMTSFSRRKNENSLLDDLSPREKVVLYWLSQGMSNQEVAQKTVLSEKTVKNHVSHMLKKLELRDRTQAAILAWKLGFAQMSPETMEQLIGDGAGIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI2</accession>
    <name>D4MAI2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">SY1_21380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SGP1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1398"/>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_0"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="127"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="247"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBL28877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="400" mass="43764" checksum="1549AED97516CB19" modified="2010-05-18" version="1">MTDKDRFIFSSESVTEGHPDKVADQISDGVLDAILKDDPNGRVACETLCTTGLVMVSGEITTSTYVDIPKLAREIVKEIGYTRAKYGFDGETCAVLTAIDEQSGDIAQGVDNAIEVRDKLSNEDISKIGAGDQGMMFGYACNETKEFMPMPIALAHNLARQLTKVRRDGTIPYLRPDGKTQVSLRYEGHKAVHADTIVVSAQHHPEAGLKEIRADIIEHVINPIVPDALLDTDTRIFVNPTGRFVKGGPMADTGLTGRKIIVDTYGGWIPHGGGAFSGKDPTKVDRSAAYMTRYAAKNVVAAGIADKCQIQVAYAIGVAEPVSLNVETFGTSRISHEKIVELIRERFDFRPAAIIRDLDLRRPQYRALAAYGHMGRIDLPHLPCWEKTDRAEELRKAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI5</accession>
    <name>D4MAI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_21460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21460"/>
    <dbReference type="HOGENOM" id="CLU_598202_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1294-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="457" mass="53176" checksum="979974890D60B33B" modified="2010-05-18" version="1">MTVLFESDWVASSPYFYNNRTGKAGPFINDVVDCANLEIDHQGLRDYMDFGYCVFGHTPVRDVHVLPHSSRLIRLDDGTLRVERMEDAAVKALDEMALSEDEIWEWIRDSVRRWEASVDGEIVIPTSGGYDSRILNWMVGDKERIRSFTYGITSPQSASSEVVYAQELSRRLGTSWQQVELGAYHNYLDEWYALYGISTHAHGMYHFEFFNAIKALLPPETRKVPMLSGHFGDDWAGRFAPLVSSPEELPLLGLTHGMNADSSQCRVREDSVARMKYWQEHRERLEDPRLRVIEVLRHKQVLLSYLFRVPEKLGYAPWCPFLDLRLAAAMLNLPPNRRKNRGWQQDFFRKNGIMVEGLCRPKRLPNTLNMQALERVPPPPLDREILSEVVVPDYVDWINKYIHRTPWNSLQEAVMSIRGMGRLWHVFTHRIPRPDRLSAYLAYLVLYPIERLLRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI6</accession>
    <name>D4MAI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_21520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21520"/>
    <dbReference type="HOGENOM" id="CLU_101011_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1295-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="162" mass="18770" checksum="545AB89A75DA50AA" modified="2010-05-18" version="1">MAQINCAEKRIVEINASAREQAKAMGIEGYAKSAEVADAWADVIISNNALEHTDYPLKELEELHRVLRPGGKIIFVVPCSNYTYAYKANDINQHLYSWSPMDIGNLFTRAGFHVLESKPYRHKWPPYYRLLARGGRRFFDLCCWLYARWETTWAQVRVVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK1</accession>
    <name>D4MAK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DivIVA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_21770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21770"/>
    <dbReference type="HOGENOM" id="CLU_786992_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1310-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="205"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="352" mass="39629" checksum="5C49CD190718C318" modified="2010-05-18" version="1">MMELLTAKDVEVKAFKKVSFGGYAVQEVEDFLNQVADDFETYAMRLNERENRIRELEEYVKKQESMTDMIKDALIQARKGAKEMEEQARAQTEQILADARVEAEKYLSEANSKVEEITSQADTTISNAEKTAAEIVAEANAKSREITSQADTTISNAEKTAADIVAKANAKSREIDSQSHMQLDEAEKTAAEIIAKAKASAAGILQEAQDMRLETEKRWADLEQDLSHRKKEASEQIEQTLASARSEAKRLVEDASKEVENYNNRLCFLNLRKQQFLKDTVALLLDFGKTIDKAQQEFEVEMMNEEEKTSVKTEAEPPVESGRQDASSSRLLDHFRRNFLEGKSDAPESGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK7</accession>
    <name>D4MAK7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="10" type="ORF">SY1_21850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1440"/>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="234"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="427" mass="47390" checksum="6898CEEE7AEF7575" modified="2010-05-18" version="1">MSCNAFDVLKARGYFEWCTSEDRLREVMQSEMVTAYVGFDPTADSLHVGHLIPLMALGWLQRAGHRPIALAGGGTGLIGDPSGKSKERNLITLEAVQRNVEGVRKQLAHFLDFDCGKNSALLLNNYDWLSRMTFLDVLHDVGKYFSVNNLIAREYIKSRLEDPEKGISYTEFSYVLLQAIDFKHLHDHYGCKLQMGGNDQQGNLLAGTEYIRKTSGGEVFGLTQPLLLTASGTKFGKTEAGAVWLDAERTSPYQFYQFWVNADDRDVERLLKLYTFLPLEDVRLLMEEHAAHPERRVAQRRLATEVTQRVHGAAAAESVAKVSAVLFDPDVDLSGLSEETCLALKREAPCSEAKLSMPAGVLDVLTACSACASRGEAKRAVRQGGVSINGVRVADEGASIDADQLRYGRYLFVRVGRKKFYVLSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL0</accession>
    <name>D4MAL0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="9" type="ORF">SY1_21920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21920"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1446"/>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_0"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="169"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="425" mass="48487" checksum="DA5361CFBF4729B9" modified="2010-05-18" version="1">MLDLRWMLAHREEVESFLKNRRHDFDMDALEALDEKRRHIIMETEDLKARRNEGSRKVGAAKKTGENVDALMQEIRLMGDRIKELDEGLSRTESELNDCLMRLPNRLSETTPVGEDEDDNPVVRTWGTPREFSFEPKPHWDIAEALGIMDFERGVLLAQSRFTVLKGMGARMERALIAFMLDLHTQKQGYLEVEPPFMVRSAILEGTGQLPKFAEDLYRIADEDLWLIPTAEVPLTNLHRESILEESDLPLYYTAYTPCFRREAGSAGRDVRGMLRQHQFDKVEMVKLCTPETSYDELEKLTADAESVLQALELPYRVVSLCSGDIGFGSTKTYDLEVWLPSQKRYREISSCSNCEDFQARRMNCRYRPASGGKPRFVHTLNGSGIAVGRTLIAIIENFQREDGTVVVPRALVPYMNGTSAIGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL8</accession>
    <name>D4MAL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22060"/>
    <dbReference type="HOGENOM" id="CLU_155311_8_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1327-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046257">
        <property type="entry name" value="DUF6290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19807">
        <property type="entry name" value="DUF6290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="87" mass="9965" checksum="67BF5262F34D4061" modified="2010-05-18" version="1">MCSTMNYTKKGDEFMAFSIRLTGEEKALAESYAKIHAISLGEAFKSALFDRIEDEYDVAVANEAYKEYVDSGRKSRPIEELWKELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAM7</accession>
    <name>D4MAM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22220"/>
    <dbReference type="HOGENOM" id="CLU_3233984_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1336-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="43" mass="4933" checksum="604B65446C29084F" modified="2010-05-18" version="1">MQDIEEGRMRVLAGDEMMQDIDGRHLVVYAAFLDGAEVDYDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS3</accession>
    <name>D4MAS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, NhaC family (TC 2.A.35)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_22900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22900"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1535"/>
    <dbReference type="HOGENOM" id="CLU_043525_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1384-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="17"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="478" mass="49860" checksum="134488804D5ADDEE" modified="2010-05-18" version="1">MSDRKLEFYGGEWMAFLPFVIFLSLILLTTFFWGSISDGALWVPAFLALIVTFFFSRDKAHYADVVISGIASREAITPVVCWLWAGVFSRLLRVSGLAAAIAGYAAGLGVGSTAFLVITFLASCLFATASGTGFGTIAAAMGVLYPAGVELGCHPALLAGIIISGAAFGDNLAPVSDTTICSATSQGVDVPGVVRSRFKYSFVAACITIAITVFLSTKLDTAASAVNANFSYDPRAFWMLAAVILTLVMAMRTGDIIIATTIGIVAAAVVGVASGQFDFLQVDAVNPAQTALIAVHGEGLDRTVDGIFYMGLASMLQVCILALLLFGSIAIMRAGGGDKKLLNALGTVASTACGAEVVISLMVIILSAVMGLNAPAILAVGASFAKPLSEKYGFTGYRAANLLDAQSNTLVYSMPWTPAVIYTISFASGTKAPLAAIQVTPFVVYGYVLMFVMFASIFLGIGRNDGSEILKKRASQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT0</accession>
    <name>D4MAT0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="15">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="15">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">truB</name>
        <name evidence="17" type="ORF">SY1_23010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SGP1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RibF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="15"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23010"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1546"/>
    <dbReference type="HOGENOM" id="CLU_428114_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1391-MON"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavokinase" evidence="16">
        <location>
            <begin position="478"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBL28975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="639" mass="69653" checksum="78E063AEA3B0E04D" modified="2010-05-18" version="1">MLSGLLLIDKPLGMRSTTCVGHLRALLGRGTRMGHAGTLDSTASGLLVLLVGAATRASDYVMMLPKLYRARVRLGEATDTCDHSGRVLHRGDASRVSAGDVDRVLLSFLGWRMQRPPEISALKLGGRPSHRLARAGLDVALRPRPVFVRSIRRTSALEEGCFDMEVLCGKGTYVRSIARDIGERLGCGACIESLRRLSTGGFHVDAALSPDRAEVLLREGRLKLQPLSAVSRLFHRVELSGAAEAALLHGLPVPLVGAGRYVPGPVPPDQAFCAEGRGLLSFVDRRDEGNGTVLRPRANVLLQDGAERPAVARGPIFAIGAFDGFHRGHARLLERARDLAALLDEDWGAVTFEPHPGVFLGKLDATLFTLRERELIRRVLRVPRLLVLNFDEEVRDLSPSDFWRRLRGTFPVGGVVVGRNFRFGRGQEGTAEALISLCRDDGLPAEAVELLTCGGLRLSSTEVRRAVMEGDAALAAKVLGFPWFFWGAVVHGDWRGHELGFPTANVDLSKALTRPGEGVYAALVPIGGRWHCGALSVGGNPTFGDVRETRAEVFLLDFEGDLYGRDLPVFLIRRLRPMTRFPDAQALAAQIARDVERCREAGREELAGRAPLYAAFAESLASMEAEDAFEPRTWRLAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV6</accession>
    <name>D4MAV6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_23440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23440"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1417-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="275"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL29001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="513" mass="55976" checksum="D8AC83ADE476CC1E" modified="2010-05-18" version="1">MTSARGRSLRSHLMWLYVLLAIFSGVVVPLLGMLFSHASFQEYQRQGRQAALDLLARSLEDLYRETGSWDRARVMDVLSLPARWGAVNIALRDQEGRVVCAAGPSGMHARGEGHGAKGRARETGHSGHVMGELSQAHGHSSTALSPLDEGSGSKGRMVIQLTSEGRVIGVLDADVRVPQGRFERAFVSHLTSYTLAGTLVMILVACGLGYMVAGRLSRPVARAVERTKRICRREYDLKPAKPSGIREMDDLTRGVEELGRSLAEQERLRQRLMTDVVHELRTPLTVVRSQIEAIADGVWEASPERLALCVSEMERLSGLIRDVESVTRMEGDAVAIKPEPVDLSAFLSSVLDAFRPLFGRTGVALRRSLAPSLHAEVDEDRFRHVMDNLLSNALRYTPKGGWVEVRLRRRGDEAVIEVQDSGSGISPQDLPHVFDRFYRADESRARVTGGRGVGLSIARAVVEAHGGTIGVESESGVGSCFTVTLPAVEGQAARSTNSMDEAESAKGPELPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y8</accession>
    <name>D4M6Y8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csrA</name>
        <name evidence="3" type="ORF">SY1_00320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00320"/>
    <dbReference type="HOGENOM" id="CLU_164837_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-14-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="99" mass="11125" checksum="DF2786957A7AF941" modified="2010-05-18" version="1">MLVLSRRINESIQIGTDVEVMVIDVRGDVVRLGITAPQATQIWRKELWDVIVAENRVAAEAAKRSAKVEGADETPQLPVSTFSRLSKIPTVRLRERDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M700</accession>
    <name>D4M700_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_00650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00650"/>
    <dbReference type="HOGENOM" id="CLU_1728717_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-27-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL27645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="151" mass="17650" checksum="D95A27F1B75B9BEE" modified="2010-05-18" version="1">MNQRIQRFDRILKLREDGRRAEQVTLAAERREERGVMDRLSALEGERAEAIAEFRGGDERVTNGADLWFQRQFIDAINTNIDRGRQSLQDVRQRILGTEARLVERHKDVRIMETYVDRLKTADFKERLDAEQLELDDVATLHCARGKRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M734</accession>
    <name>D4M734_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01140"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.383"/>
    <dbReference type="HOGENOM" id="CLU_102849_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-61-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="167" mass="19730" checksum="708606C1D62A9139" modified="2010-05-18" version="1">MEFRDRQYEVFNMFDKQWALATAGTLEDFDGCTIGWGSLGSLWGSRSDGRLIVTIYVNPLRYTSEYLLKNDCFTVSFFEENYRRDLLTLGTKSKRDCDKFAMTSLTPERHGQGVVFREANLTFVCRKLYWEQFNPDHLDSEVMREIYSNRPPHYQFIGEIMEVLDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M740</accession>
    <name>D4M740_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01200"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.390"/>
    <dbReference type="HOGENOM" id="CLU_116644_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-67-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="116" mass="13685" checksum="C90B7060A5F5A0F8" modified="2010-05-18" version="1">MLFLWYPRCSTCRKARDWLDAKNLSYTFRDIVQEPPTVQELQEWQRRSALPLKRFFNTSGMNYRALGLKDKLPEMSEEEALRLLASDGMLVKRPLLVTEEIVLIGFRETAWVDAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M752</accession>
    <name>D4M752_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01440"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.661"/>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-79-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="277" mass="31648" checksum="2626C56929069669" modified="2010-05-18" version="1">MTNFALLQTDIEFCNPEANFSHVRSMFAEAMKKTPRPDVVVLPEDWASGFSDEMFRHMEKYAEPEDGPTVTMCKGLAREYKVWLVAGSASILHRDGKMRNTTYLIDREGEIVGDYSKMHLYSDMDEDVPFEHGDKIEVYDTELGRLGMMICYDIRFCELSRTYALKKADVLVVASDFPNPRVNHWRTLLMARAIENQMFVVACNRVGSSPMGTYCGHSIIIDPWGDVIAEGSDGEEIVTGSIDYTKTREVRDLIHMFRDRQPHLYGDTLLRPQAQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M759</accession>
    <name>D4M759_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01530"/>
    <dbReference type="HOGENOM" id="CLU_2953810_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-86-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="59" mass="6494" checksum="EFCB5A6C549AD1A7" modified="2010-05-18" version="1">MMGGERMSVEVQERVALWRVPDPTEPPLTPEEIAGVEQARAERAAGLGRPIAEVIRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D4M761</accession>
    <name>D4M761_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01550"/>
    <dbReference type="HOGENOM" id="CLU_3434966_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="14" mass="1439" checksum="CFB28EBAEBE24162" modified="2010-05-18" version="1">MAVSSCVGGSLLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M774</accession>
    <name>D4M774_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01750"/>
    <dbReference type="HOGENOM" id="CLU_3099134_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-100-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HGTP_anticodon" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="51" mass="5425" checksum="8E52CF6746D32036" modified="2010-05-18" version="1">MKNAGASGARWACILGPEELAKGCAAVRDLEEGSQTEVPLAQVPDYIQNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M775</accession>
    <name>D4M775_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="3">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisS</name>
        <name evidence="6" type="ORF">SY1_01760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01760"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.822"/>
    <dbReference type="HOGENOM" id="CLU_025113_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="5">
        <location>
            <begin position="45"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="390" mass="43859" checksum="7DBA3EA9046F9DB8" modified="2010-05-18" version="1">MRRARRFGGRAGEIAAEREMNAMEIKAPRGVRDILPEESWKWAYVVNTAARTMADFGFSEVHLPLFEQTELFARGVGDTTDIVEKEMYTFTDRGGRSLTLRPEGTASMVRAAVENGLCAQGTAAKLWCWGPMFRYERPQKGRYRQFYQIDAEYLGVAGPMADVETIDLSAELFRRLGMKNLEVVINSVGCPRCRPVYREALLQHFQARRGELCETCLERMDRNPLRILDCKEPGCGTVADAAPAIYESLCDECRSHFEEVRSGLERLSFRYRLDKRLVRGLDYYTKTAYEILSGDLGAQNAVCGGGRYDNLSEAIGGPRLPGVGFACGLDRIVLVMEQQGCTFGRRPQARAYVAALDGASRGRPRSWPTSCGARASQRNRTRRTEASRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M790</accession>
    <name>D4M790_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02010"/>
    <dbReference type="HOGENOM" id="CLU_1105877_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-117-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="41"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="251" mass="26987" checksum="83BE80A124F9F1C5" modified="2010-05-18" version="1">MKERIYRAILTLAFTLSLLSLRAGMASAESLKFTGSPHFLPAPLMVVGVYTPEGQANFAPFHRGGVLASGKDGGPMRIGFGIKGDAEKSWTYQCLKKMKACTVNLPSVKYLAEAELLGRYSGRPLSGDAPLLSENGGFQDKLAVTKLTAVKGSAVNAPMIEEFPISLECELEEDMPIAEGSKSRLMILVVRKVWADEAYLDAGGKINPKTADPDSSIVFFSHSHAANGGFYGYGEMLGKSGPISDAYRQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A6</accession>
    <name>D4M7A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1636"/>
    <dbReference type="HOGENOM" id="CLU_064691_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-134-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039065">
        <property type="entry name" value="AcoX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011386">
        <property type="entry name" value="Put_ATP-NAD_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697">
        <property type="entry name" value="PTHR40697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016907">
        <property type="entry name" value="Kin_ATP-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="370" mass="38896" checksum="BF6A424CE3EC861C" modified="2010-05-18" version="1">MKIAFLVNPVAGMGGAVALKGTDGAETLRRALALGAVPRAHLRAGAALSAALPVPDGVRFLSCGGEMGEAILASLGIPCGVVYAPEGRTSGEDTRRAARAMAEAGADLIVFAGGDGTARDLCAALEGRAVPVIGVPAGVKIHSAVYGVTPVRSGQLLAKFMNGQVRDFTRADVMDIDEEAFRQGHVNARFYGCLTVPLDRSCLQDRKSGGMARDEYDRTAIGAWLADQMRPGRLYLVGSGTTTQAVMDALGLPDTLLGVDAVRDRRLVGRDLTERAILEMARPGDTTLIVTVIGGQGHVFGRGNQQLSPEVIRTAGRENVVVAATPAKLNALFPRPLLVDTGDADLDRALSGYVPVVTGWARRQMCRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A7</accession>
    <name>D4M7A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1637"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-135-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="250" mass="27148" checksum="2E85C2EE1D726F44" modified="2010-05-18" version="1">MARYEELEGRRVMVTGAASGIGLATACRFAEEGARVFVVDYNAEALEETRKAHPEFAGFSPADVSREEDVAAAFRQMDRELGGIDVLISNAGISVRNGVLDVSYSQWNRTMGINLGGMFLCAREAGRRMKEQGGGVILMTASTNGTEGHRWYADYNASKAGVILLTKTMALELAPVVRVNCVCPGYVLTPMQRAEYTDEMLAKVNEGIPMKRHAEPEEIASLYAFLASDDARYITGADVRIDGGETAGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D5</accession>
    <name>D4M7D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_02630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1740"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-165-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="260" mass="28614" checksum="F596A70B65A21E49" modified="2010-05-18" version="1">MNPTSKSAVLELKGVNKFFGGVQAVSDMSFVIRRGELAGLIGPNGAGKTTIFNLVTGVYDTNGGDIKFMGKNVNALRSYQVIRLGIARTFQNLRLFPGSTVLENVMTAAQQHHGYSFFEAITHLGRWRGREAAIRGESMELLEQVDLADRAEQAAGTLPYGLQRRLEIARAIALQPQLLLLDEPAAGMNADEVHDLNELITQLHQKLGLTILLIEHHMDMVMAICPHIICMNFGAKIAEGSPQDIRQHPEVLKAYLGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E3</accession>
    <name>D4M7E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_02760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02760"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1755"/>
    <dbReference type="HOGENOM" id="CLU_028518_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-173-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="298" mass="32767" checksum="F71F1B523E20BA0C" modified="2010-05-18" version="1">MSETRKGRLRAFFQSEFFYNFRRSPAAVAGALIVVLVLLVALIGPYFTVQDPYNMAELQLSDAYKPPFWMEGGDPKFLLGTDQQGRDMVSAIVYGSQVSLVIGLLGTLMASAIGIVLGLASGYFGGKVDALIMRIADVQLSFPSMLIALFLMSILGRSVANILLSLMLVGWVRYARTVRGETLSVKRNEYIEAAHVIGLPNWRILFRHVLPNVFASIVVLSTMQVGGFILTEATLSFLGLGVPISRPSLGMLCNNGFTVLYSGLWWVSILPGLYIMIIVFGINLLGDFLRDEMNPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G6</accession>
    <name>D4M7G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein probably involved in high-affinity Fe2+ transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_03060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0423 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03060"/>
    <dbReference type="HOGENOM" id="CLU_100963_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-196-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018470">
        <property type="entry name" value="Metal-bd_Tp34-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038482">
        <property type="entry name" value="Tp34-type_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10634">
        <property type="entry name" value="Iron_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017018">
        <property type="entry name" value="Tp34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003060991" evidence="3">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="197" mass="21431" checksum="059A7C65DC74E4B0" modified="2010-05-18" version="1">MKKLLVALMVLCMALVAGVAFAAPAAEKPGESGFAEIPIGEEQQVGPYNVAAVYFQAVDMYPAGKNPSKEDSDMHLEADIHLKPEDAVKYGFGNGDNIWPAYLTVKYEIIDKAGKTAMEGSFMPMNADDGPHYGANIAKGLKVGAYKLRITIEPPTDYLLHTDPETGVPAKEGAAEYFKTHVAEFDWNYTGEQLQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H1</accession>
    <name>D4M7H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_03150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1792"/>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-201-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="141"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="360" mass="39993" checksum="43F6F3F228909C43" modified="2010-05-18" version="1">MNGDRVKRVLCGMRELGVTDFLLMDPLSILYLTGQDVRPMERFFALCLRGGGRPILFANRLFGLKEDPDLEVVLHSDGDPVMALVTERLHRGNVGKLGVDKGMPARFLLSLLERWAPEDLIVASPAVDLARGVKDAEERERMAASSRVNDQAMGRFKGLVHEGVTEAEVARQLLDIYLELGAEGFSFSPLVAFGANAADPHHAPDGTILKEGDCVLFDVGCRKDGYCSDMTRTFFWRSASEHHRQVYETVRRAQETAEAGVRPGVRLCDIDALARDVITAAGYGPNFTHRLGHFIGLETHEYGDVSPADCRMTEPGMIFSIEPGIYLKDDIGVRIEDLVLVTEEGCERLNRYSKELEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H3</accession>
    <name>D4M7H3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">SY1_03190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03190"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1798"/>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="220"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="230"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="334"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="456" mass="48530" checksum="C51F08838F8229CE" modified="2010-05-18" version="1">MHAPSDTVAAISTAWGEAGIAVVRVSGSCAVPLARSILRFGPKGFPPPRTMRLAALLDGADNAIDQVLAVHFPGPHSFTGEDVVEVHTHGGTLVAQLCLEGLLRRGARMAEPGEFTRRAFLNGRMDLSQAESVLGIIRSRSEEALRAAARTLSGEFSEFVRQIRDELLTLQGDLEVGLDFPEDAAPAVDPIGLYDALETLRITLRDLEDRCSLGLLLREGIRVVISGRPNVGKSSLLNALLKQSRAIVTAVPGTTRDIIEETVTYRGIPIRLVDTAGLRVPSDEVEASGIERARAALKQADICLWLLDGSAPLEDADRDYIRSLGTRESIIVLNKADKALAVTEDDLRAIVPEGRTLAISAKTGEGLDALKEAIAAIATAGGALDVGLNVTARQLSELRACAEAIAEAQRVLEADMGQDVTAALLGTARKALERTLGIAADDDLLDSIFSRFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7I6</accession>
    <name>D4M7I6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">psd</name>
        <name evidence="7" type="ORF">SY1_03470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="5">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03470"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1825"/>
    <dbReference type="HOGENOM" id="CLU_072492_2_0_0"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023318456" description="Phosphatidylserine decarboxylase beta chain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023318460" description="Phosphatidylserine decarboxylase alpha chain" evidence="5">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="5">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="206" mass="22544" checksum="42CD35D4A1597F56" modified="2010-05-18" version="1">MRFARDGFFTIAASVLLTAFAALFSLALGAAMGAFTLFVLWFFRDPDRSTPDRENAFFSPADGRVVEILEVEHPFTGPAVRVGVFMNVFSVHVNRAPCAGQVAFLDYVPGKKVAAFAAKASEVNERNFVGLSTPRGPVMMVQIAGLLARRIVCRLKLGDVLEAGQRYGMIRLGSRVDIYLPREVRLTVKIGDKVYAGVSLIGEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7I7</accession>
    <name>D4M7I7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_03480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1826"/>
    <dbReference type="HOGENOM" id="CLU_049944_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-217-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="252" mass="27264" checksum="2A3971D0FFC38378" modified="2010-05-18" version="1">MSFFRRKRGSARKPLEFRQIAPNMVTSGNLLCGVFSLMLTTQGMFVPAAWLVFFAVIFDGMDGKVARMLGGGSQFGLEFDSLADLVSFGVAPSILIFQTSLRGFGGLLGAAAACFFALCTALRLARFNVVHVPGPFQGLPAPAGGLFVSSFVLAGADLPAGAMAAVLALTGFLMISSIPYANLKRLTKRSADRRKCLALSSLLVLSFAFLRNAAPLFLFFAYVLSGLLHFDWGRWLLRPEARDEEPRSHEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J0</accession>
    <name>D4M7J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03540"/>
    <dbReference type="HOGENOM" id="CLU_097806_7_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-220-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="128" mass="14371" checksum="BEDCAD64DFDC8949" modified="2010-05-18" version="1">MTHYNLPHDHGQDVQVVLERMPAAQRFEEAAMSFQQLGDPTRLKILWILCHCRECVSDIAAAVGMSDAAVSHHLQLLKRSGLIVGSRVGKEIHYTLSDERRAGLLHRMMDALFEITCPKEDLPGPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J5</accession>
    <name>D4M7J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted amino acid racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03640"/>
    <dbReference type="HOGENOM" id="CLU_067103_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-225-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="371" mass="41012" checksum="C284A05A5C916FD5" modified="2010-05-18" version="1">MRYPQIRVDLDKLLENARVLSGLLSAHKLKFHYVTKCFCAWEPMVDALADAGIRNFADARLENIEVLKRWARSAMLLRVPMISEADDVVCLCDVSLNSELAVIEALSDAALTLGRTHEVILMVELGDLREGALPEDVMPMVEQILTMRGVKLAGLGVNFNCYGGVIPTPAKLKELADLAKEAQNRCGYEFEYVSGGNSGSLPLVFDDRIPSGINHLRIGEAFLLGHETSYGSSIPGMLHDVFTLRCEVIEKKLKHSVPSGERGLNAFGEPPAEMEDRGMIQRAIIAVGGQDTFPFSLTPRMEGLRYLGHYSSDHTIFDVTHAKGDVHVGGTLDFDVDYKALLMIFMSKYVEKVPVWAGQYFMMAVGMKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N2</accession>
    <name>D4M7N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carbon starvation protein, predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SY1_04250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1912"/>
    <dbReference type="HOGENOM" id="CLU_010531_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-263-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="10">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="10">
        <location>
            <begin position="288"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="11">
        <location>
            <begin position="456"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL27877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="632" mass="67846" checksum="2B0BDA399F69608A" modified="2010-05-18" version="1">MITFFVALAALIVGYCTYGLFVTLVFKPDDRRTPCQVHPDGVDYVPLPIWRAFLIQLLNIAGLGPIFGALSGAIWGPSVYLWIVLGTIFAGAVHDYLSGMLSMRNDGASISELTGMYLGPTMKTVMRIFSVVLLVMIGVVFMVGPAQLLSRMIMGAGRDFNLPRTAAVSIQAAPAVAAPKTEAEKTAAPKADEGKVPVEAKPAPIEEAKPEAPAEEAKPAPVEEVKPEAPAAEVKPVPAEEVKPETPAEEAKPAPTEEAKPEAAAAEEVKPVAEPEMVYGLTEAEWVKYLTIAILVYYFLATLLPIDKVIGRFYPIFGLCLILMAVLIGGATVMNHLNGTHPMIELWDGLYNMHPKGATTPIWPLMFITVACGAISGFHATQSPMMARCLTSERQGRFVFYGAMVAEGIIALIWASAGIAFYNTFGSPITTEGLFLARGGNSATVYDISKGLLGSMGSILALLGVVACPITSGDTAFRSARLTLADWFKIDQKAIKPRLMLALPLLLIGYAISFVDYGIVWRYFSWSNQTLAMIALWAGAVYLCRNVSPVSGFMAAIPATFMSAVSSTYFCFAPECLGFATKFSEGLTLCGVTVDGVQLSYGIGLVFALVLFSIFFGVHRSANYYKSLKKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R2</accession>
    <name>D4M7R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04820"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1975"/>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-293-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="66"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="396" mass="45234" checksum="9FFB00271921459D" modified="2010-05-18" version="1">MAYDFDKVIDRRGTSCSKWDADPNKTIPGVEYPVDRDVLPVWVADMDFEVAPEITEALAERVRHGIFGYTKVPDACYDAIIGWQERRHGWRIKREWITFTPGAVSAAHMAMQAYCQVGDTAIIQPPVYYPFYRTVHNNGGLLSCSCLRRSGSRYEMDFDDFERRAAEDRTTVFILCSPHNPIGRVWREEELERVGEICMRHGVRVFADELHCDIVMPGYRHIPFAGLNPEFAAHSITVISPSKTFNLAGLQATAAIIPDPEMRRRFENVKARNSLSDPNLFAITAMEVAYSRGDKWLDEVLAYIKGNYDFLVEYMGKKLPKVKVMPLEGTYLAWMDFSAMESDERALQKRMLTRGKVWLDEGWIFGEGGAGFERIVLACPRSTLREAVDRMARAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R6</accession>
    <name>D4M7R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M20.020"/>
    <dbReference type="KEGG" id="sbr:SY1_04910"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1983"/>
    <dbReference type="HOGENOM" id="CLU_023257_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-298-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="225"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="426" mass="45736" checksum="182728BBF6C44A86" modified="2010-05-18" version="1">MDLKELERRMIETRRDLHRFPEPAWTEFRTSALVAARLEGLGYALKMGSEVIDAGSVMGRPSEEEIDREIARAVEQGGDRERIERMGRYTGVTADLDTGRPGPTLAFRFDMDCVDVGEDMSPDHRPAKEGFASVNPCRMHACGHDAHTAIGLGVAELLTEMKGRLCGRVRLIFQPGEEGCRGAYAMMKKGVVDDVDFFLAMHIGGGVPTGTFGLNSLGYLATTKLDARFTGVPAHAAGAPHMGRNALLAAAAAALGLHSIAPHRDGAMRLNVGVLQAGTGRNVVPAEALMKVETRGETQEVADYVYGRAEEVLKGAAEMYGVRVELSKAGEGTTARGDEELVRRVGAALRASGIFRSVLDTVRAGGSEDATWFMRRVQERGGEAAYMALGADIAAPHHNGRFDVDERGMILGARAMAAIAESLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S3</accession>
    <name>D4M7S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">The GLUG motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1993"/>
    <dbReference type="HOGENOM" id="CLU_651738_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-305-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glug" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="1">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="421" mass="43119" checksum="AD37703F8E383CCA" modified="2010-05-18" version="1">MKSLRTRNLRSRRGALNIVVLFLLGIVLLANGGCGGSGRSENAASPFAGGQGTQEDPYRIATAEQLTKIRDYRDKSFILISDIDLSSYGNWDPIGTFNREIDDPEKSEVAKSSLAFVGRFDGNGHTISNLTVNRPETVGVGLFGFVVGNAASQSIRNLTVSNADVKGACMVGGVVGVINGGITGIKLTGGNRVEGYAVGAVGGIAGMGYGAIENCTANASVTSNGKGMQGLGLICGGGKWLTVRACTAEGNVTAKGFGAFSVGGLVGCIQESPIMENCAVKATIDASDEKSFMVGGLTGHAGNYDKSNPTLIRNCSADVDITVSASSKRVGGLVGGNLFVSAFLEEHPTPSIYRITGCATSGSIKGNASQVGSIAGYGYDCSVTDCTSTLVWSGGAIKPVGLMQSAGETPDPIGLDYYAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y2</accession>
    <name>D4M7Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FeS cluster assembly scaffold protein NifU, Clostridium type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2077"/>
    <dbReference type="HOGENOM" id="CLU_079283_5_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-364-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017787">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03419">
        <property type="entry name" value="NifU_clost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="137" mass="14967" checksum="5940CC319D387329" modified="2010-05-18" version="1">MALDYSQKVMDHFTNPRNVGELKDADGVGEAGNPRCGDIMKIYLKVNDRNVIEDVKFKTFGCASAIASSSMATELIKGKTIDEAWDMTNQAVAEALDGLPPVKMHCSVLAEEAIHAALNDYRTKHGMAAIPMEKHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M807</accession>
    <name>D4M807_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2112"/>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-389-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="384" mass="41579" checksum="33B5BB79E37FFDB7" modified="2010-05-18" version="1">MLTKYDLKMPSAVYSGEDALTNVGNVLAENGVKKLAVFTDKGIEGAGLLEPPMAEVRRTGVEFTVLDDLPAEPSYAQAQKLVDQCRESGADFIMAVGGGSVMDTAKLSSVLMTDEYGIKELLEDPGRARKHVKTLMIPTTAGTGAEATPNAIVAVPEKELKVGIVNPRMIADYVVLDAVMVKKLPRKIAAATGLDALAHAIECYTSNKANPFSDIFALQALDMILNNIERACDDPKAMEAKRMMQIASFYGGIAITASGTTAVHALSYPLGGRYHIAHGVSNAILLAPVMRFNEPACRELLAHAYDRCIHGDASSTEAKSAAVITRIEEIVRHLDIPVSLQEFNVPKEDLESLVQSGMQVTRLLVNNRRPVTEEDARRIYQEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M831</accession>
    <name>D4M831_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KWG Leptospira</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06600"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2150"/>
    <dbReference type="HOGENOM" id="CLU_447502_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-413-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061178" evidence="1">
        <location>
            <begin position="27"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="626" mass="67311" checksum="9AAD18AA0EDAD6C2" modified="2010-05-18" version="1">MRRTRRLHAAFALLAALLTFCGEAGAARIDWFLQPVWDRASRFSEGLAAVCSGGRWGFIDPAGRWAVEPRYEDAQPFRGGLAAVLLDGRWGFLDLKGRLAVKPAFAAASSFSEGLAAVRAGDKWGYVDRRGTMAIAASFDLAGDFYQGRAAVTSGGRCFFLDPKGVRVGSLDFDAAWPFVEDRAAVVVDGRMGFIDREGRMAVPPRYDPPVGGRVFSSGLAGVEIQGLWGYIDLNGSWFVEPFCEGVGDFSDGLGPVRRGGRWGFVSLSGELAIPYAFEDVMPFSEGVASAAVGGRWGYIDRLGSWMADPVFLEAWPFSEGLAPVRSALNGRWGYVGRNVAPLFGGRAFDGAEPFSEGFALVALAGRRFFIDEEGRDAFDAAFADARSFSDGLAAVVAGGWWGYIDRQGRTAIPPQFEAAGAFHDGLAPVRAKGKWGYIDRRGRWVVKAAYDAAWPFSEGLAAVRKGRSLGYIDAAGRTTIPFKLTPPGDGAEAGPFSEGLAAVLSGGRTAFMDRGGRVVIKGAFKAWRGAAPRFRSGIAAVEDGNGREFFINREGDDVGARGFAAAEKGAATLVRPYRAPSGLFGYRRSDGVILVPPFLERAGEFQDGRAPVSLGGRWWYIPQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4M862</accession>
    <name>D4M862_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">SY1_07140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07140"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2203"/>
    <dbReference type="HOGENOM" id="CLU_023625_3_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="129"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="415" mass="45536" checksum="4A99E301150EEA48" modified="2010-05-18" version="1">MVRERTRRAELTVDELNAYIQGLFNSDLLLKALVISGEIAEFKRHTSGHCYFTLLGTDTRISCAMFRRDADLLPEWPRNGDQVLIEGSVGVYPQRGVYQLYARRLIPVGAGAIERARQELKRRLELEGLFHPSHKRPISPYPSRVAVITSATGAALRDVLRISGRRYPLSDIVVVPTLVQGPDAPEDIVRAFARAGAMSGVDCVLLVRGGGSREDLVPFDDERVVRAVRNCPFPVVSGIGHEVDSTLSDLAADLTASTPSAAAEVVFPDRAALLAWLAQVRQRVGGSARRRIGVERARCRLALEGMERALKLRTGTERSRLHEGLRALSRSMTLRLRDARSELSTRAASLSGLSPLAALARGYVIAEREGRRLFSVREALSGAALSLCFRDGRADCLVRAIAPFDPPNEGALEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M880</accession>
    <name>D4M880_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpD</name>
        <name evidence="5" type="ORF">SY1_07410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07410"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2229"/>
    <dbReference type="HOGENOM" id="CLU_069688_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="206" mass="23670" checksum="483A089B3023CC49" modified="2010-05-18" version="1">MARINVNPNRMELSKLKKRLTTAVRGHKLLKDKQDALIKAFLEKARAGKELREKVEKELAECYGTFVLSRAQTTPEVLEQALMFPGASCSLSVKWRNVMSVMVPEYDVEQEGNPVNYGFVSVPVLLDTALEQFSKLILRLLEMAAEEKAIRMMAGEIERTRRRVNALEYVMIPNYKETIRYISMKLDEQERSTLSRLMKIKEIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D4M885</accession>
    <name>D4M885_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">SY1_07490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07490"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2237"/>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="238" mass="26142" checksum="7545ECEBA930B01B" modified="2010-05-18" version="1">MPRYNRVLLKLSGEVLAGDERFGLDFDAVRRVGAEMVELHGAGIQLSLVVGGGNMLRGRDVQKLGIERSQADYMGMLGTVINALALQDVLEKMGVPTRVQTAIEMREVAEPYIRRRALRHMEKGRIVIFAAGTGHPFFSTDTTAALRAAEMGVDCMVKGTKVDGIYEADPKSHPEARFFPHLSYSEALQRNIEVMDASAFSLCRENRIPILVLNVQKKGCLVSALVNGERIGTIVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A3</accession>
    <name>D4M8A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07790"/>
    <dbReference type="HOGENOM" id="CLU_023257_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-488-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="185"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="390" mass="42246" checksum="571BEA5C453C169F" modified="2010-05-18" version="1">MDIKALAERYEPYIVERRRYYHSCPELSNEEKETSAQIRRDLEAMGIAVREVSGCYGLVADIRGGSQGATVALRADMDALPIEEDTGLPFASKNEGRMHACGHDNHVAMLLGAAQILNEVKAELHGTVRLLVQPAEEVASGALDMLKGGALDGVSAIYGAHVWGNFDAPLIDVTPGSRMACCDKFTIEVEGVAAHASAPHLGVDAITVSAAIINNLQQCVSRMNDPLNPLVLTIGFIEGGPRWNVISNRVRMEGTVRTFDEDLSKSEIMRRIIADTAAAFGAKGTLEYKRLTPPLINGSDKLNAIAREAVVKLYGEQAVGHMPTMMGSEDFPWLSDGGRIPYIFAFIGSRNREKGITYTNHHEKYTVDEGILTRGAAVMAQFAADFLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A7</accession>
    <name>D4M8A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil-xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_07840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07840"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2275"/>
    <dbReference type="HOGENOM" id="CLU_017959_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-495-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="471" mass="49205" checksum="572CFAE0438E0F72" modified="2010-05-18" version="1">MSGEMKSIGNEAIYDARSLGVGRMLILGVQHLFAMFGATVLVPLLTGLSVSSTLLFAGVGTLLFHMIAKWKVPAFLGSSFAFLAGYAAIAPKGDPALLPYACFGVACAGLVYLLLAAAFRAFGASRVMRYFPPIVTGPIIIAIGLTLSQSAIENCSKDWFIALVAIVVVIACNIWGHGMVKIIPILLGVAGSYLAAVAIGAVDFSTIAAKPWFGFPVEYGQTVFAIFTNGRVNFDLLISSVITIVPIAFAAMMEHIGDISAISSTVGINFIRDPGLHRTLTGDGLATTAASLFGAPANTTYGENTGVLTLTKVYDPKIIRLTAVFAVLLSFCPKFAAAIESMPTATIGGISLILYGMIASVGVRNIVETNVDFSQSRNVIVAALILVLSIGINYSSAGALNFTLGGIGIKFSGIATGSLVGILLNAVLPGKDYKFDDDVPNRTGVNLEIAQGKSLDWRASDGVEGQDTVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A9</accession>
    <name>D4M8A9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">SY1_07860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2278"/>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="142"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="431" mass="46103" checksum="97A3C3E02D120CEB" modified="2010-05-18" version="1">MWKHAAIEKVTGREILDSRGNPTVEAEVVLSDGTVGRGIAPSGASTGEFEAVELRDGDEKRFGGKGVARAVANVNTVINDVLRGLNPQSVHTVDFAMLKADGTPNKSRLGANAILAASIASARAAAESMGVPLFRFLGGVNASLLPVPMMNILNGGAHAANSLDIQEFMVMPVGAPSFREAYRWCSEVFHSLRGILKGRGRATGVGDEGGFAPDLKDDEDAIQSILEAIQKAGYEPGRDFVLAMDAASSEWKSEKGVGFYHQPKSGLDLTSDELIAHWEALVDRYPIWSIEDGLDEEDWDGWKKMTRQLGGKVQLVGDDLFVTNTERLSRGIEMGCGNSILIKLNQIGSVSETLDAVRMAHRAGYTAVVSHRSGETADTTIADLAVALNTGQIKSGAPSRGERTAKYNQLLRIEEALGNAAAYPGVHAFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B4</accession>
    <name>D4M8B4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="6">DHOD</shortName>
            <shortName evidence="6">DHODase</shortName>
            <shortName evidence="6">DHOdehase</shortName>
            <ecNumber evidence="6">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrD</name>
        <name evidence="8" type="ORF">SY1_07910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07910"/>
    <dbReference type="HOGENOM" id="CLU_042042_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="7">
        <location>
            <begin position="10"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="313" mass="33535" checksum="F8EBD245DD035FE6" modified="2010-05-18" version="1">MSELKYRTDLSVKVGGITFKNPVMPASGTWDCFENNAGLFPMSELGAVLVKSVHRLVRQGNPPPRIAEVTGGMINAVGIPSVGIEAFMTQELPRYDGIGAPVVLSLSGNRKEHYREALEIVANDPRIAAVELNLSCPNIGTGLAFSSTPDVLRETLKAAREATRLPIFVKLAPNVTDIRVSARVSEEEGADAVTIANTWRAMLIDVETRSPVLSNVSGGMSGPAVKPQTLFLVWQARAATAIPIIASGGIARWQDAVEYFLAGASMVQVGSANFQNPAAMVQIVDGIDRYLAEHGHRALSEIRGLAHQRRGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C1</accession>
    <name>D4M8C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_07980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07980"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2292"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-509-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="78"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="177" mass="19264" checksum="2DA74DC98F395603" modified="2010-05-18" version="1">MQYLGRYTSPLGAITLGSDGESLIGLWFDGEKFFCDKITEDTEEGNLPVFDTTRRWLDVYFSGRAPDFTPPLKEIGSDFQLAVWQILRAIPFGHTVTYGDIAGRLARQRGLARMSAQAVGGAVGHNSISIIVPCHRVVGANGSLTGYAGGVDKKQKLLTLEGVDMSRLFVPRRGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C3</accession>
    <name>D4M8C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_08010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08010"/>
    <dbReference type="HOGENOM" id="CLU_3382004_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-512-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="33" mass="3637" checksum="9FF34A9EA00D73F2" modified="2010-05-18" version="1">MADDVKTILDEAGVSREAFDTDTNGVRGRRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C6</accession>
    <name>D4M8C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box/diguanylate cyclase (GGDEF) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_08070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08070"/>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-515-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="204"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="351"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="617" mass="68160" checksum="3F10F3203D6EAD23" modified="2010-05-18" version="1">MKPFRPAAPSFGLLDEALSALLPADDGDSALSGRQAASLSTEQLLASRDAILDQLPVPLVISDEQDRILYANRALLSLINGPEDFLKGKKLPSILVPRAKLDPHSEDAQDPAERERQDLPDGQALILLGAEGVALPVKQLTGSVTWNAYKLTLSALFDLSEQQAANERLLRIAYYDSLTGLPNRDCFMDSLNQELRKLNSADGYTFSVILLNMDRFKLLNEQYGSDTADKVLIEVIERTKTILHGFATIFRTGGDEVMAILKGVSSQSYLESTLDRLLKLISLPIWIDGDSVFPSACLTAMLDIPKDFSALQVLGGLSSSMKAAKKRGLGCVLFVSPATEHRDKEAKHKDILKVTAEIQTSLLNDQFIPYFQPIYNTATMQLLGFETLARWRHPTGDILPPGAFIPEAEESGLLTAIDRSIVSQALAVMESFTRKYPNLNFHLNANASGLSLKDASFFDFIEGKLKNVTFPTDRFTLEITEDVLMENLGEARGRLEKLKKLNISVALDDFGTGYSSLQYISQLPVDSLKIDRSFIDQMLKSRKTASLVKSVIEMARSLNLGIVAEGIETKDQNQWLAEYNVAGQGFFFSVPLPVEKADEFLKDVSVFAELIKEMPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C7</accession>
    <name>D4M8C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_08080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08080"/>
    <dbReference type="HOGENOM" id="CLU_195100_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-516-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="70" mass="7267" checksum="76E975399449D214" modified="2010-05-18" version="1">MSIAVSEVSANLKKPLAPVGAKGIDVAKGGRGAAKLSTPCQDRVDVAKSLFGVLAADVTLEEAMEERRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C8</accession>
    <name>D4M8C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate butyryltransferase</fullName>
            <ecNumber evidence="3">2.3.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_08090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.19" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.9"/>
    <dbReference type="HOGENOM" id="CLU_056531_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-517-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050182">
        <property type="term" value="F:phosphate butyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="87"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="309" mass="33335" checksum="52E9BD60478512F8" modified="2010-05-18" version="1">MEQIRSLSQLIEGAKKLCAEKGKKRLSVAMAEDAGLIAAIEEARKAGMVEATLVGNPDRVRACIQEAGASEKDYNVIEERNEAKCGIVAVTEVSAKRADIYMKGQLHTDHFLRGMLNKEVGLRSGKTISHCYFHHIPGYDRVLFIADAAFNMYPDVKQKADILQNTVNFARALGVECPKVACLAAVEVVNPDMPCTLDACALVQMNQRGQIRNCIVDGPLALDNAINEEAAKIKKINSPVAGHADILFVPQIEVGNVLAKSITYFSRDSETAGLIIGAAAPVILTSRADPMRAKLLSIAGAVMMAHHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D9</accession>
    <name>D4M8D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Flagellar motor component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_08340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.31"/>
    <dbReference type="HOGENOM" id="CLU_079895_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-528-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="82"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="239" mass="25375" checksum="54131614EE16A1E2" modified="2010-05-18" version="1">MAGGGNFGAYIDVPSMMITIGGAVGATILSNPSDRLKAIGGGLKSAFVSHEPNLVGMVQMIVSFAEKTRREGLLALESDVAELDNEFLKKSIQLVVDGTDPELVRAILDTEIGVLEDRHSANKSVFDTLAEFAPSYGMIGTLVGLIAMLGNLADVSSLGPNMAVALITTMYGSMMANMFGIPIGKKLAARSAQEVVAMELMVEGILAIQAGENPRIVEEKLKVYLPPRLRSSFDKKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E4</accession>
    <name>D4M8E4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_08400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08400"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.37"/>
    <dbReference type="HOGENOM" id="CLU_357437_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-537-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="231"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="784" mass="88984" checksum="876F08ACFE4A76AD" modified="2010-05-18" version="1">MLNERGREAPFQDEGGKEMRFSELVKSLDRARRYLRDFYLFGYRTREEYEARRSYDNERRRIESWLGDSMRRTPAPGGRAVSLCLDAADEPRNPLYALWATKSFTRNDILLHFLLLDLLSDGASLAADEATDALAERWGEVFGTATVRLKLKEYAELGLVEEVDSGRRQRFRLAPLCAEDLGGDLLEAVDLFTEAAPFGQIGARIQDELGRVNVLFRFKHDFLVHTLDDAVLLTLLTATAEGREVVLKLRDRTVSGTPVKALFGLQSGRRYGVLHRGGRFTLIRLDRVDSARLGEPVPDFEAKRQAFDALLPRLWGASLPYPLREERVRMVLTTEGRRERYVAERLKREGRGGSVTERPDGTIVYERRASDSMEMLPFLRTFTGRILSLKGDNRRMLRRFHDDLRRMEALYSGDGGSVPCGPMPKEGSVPRTARSGSKGNAASDGGRCRAADALFHEAFGRYYVIAARLLERADREGPLTLEAIRRRVARWGFAETPALMLPPLTEGEWPLFQRGADRAFVPRLRSVRRPLSTLERRWLAALLEDERMGLFLEPEALRRAKARLSGAAPLFRASDLCAFDRSHDPDPFRDEEYRSVFRTVLTSLREGRLLWARFTSGHGREVRGNFLPRRLQYSLKDDRFRLLARRADPGLPAWEETINLARIQCAVLGTRYAAAEGAALPSARTEPVVLLLTEERQAMERALLHFASFPCRPQTGPSGERLLHILYDTQDEKELLIRVLAFGPLVRVLGPERFVEMVRRRVREQARLLGHAAPQGEGDTKGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8F1</accession>
    <name>D4M8F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar basal body L-ring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_08490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FlgH family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08490"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.46"/>
    <dbReference type="HOGENOM" id="CLU_069313_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-544-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009427">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, L ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000527">
        <property type="entry name" value="Flag_Lring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34933">
        <property type="entry name" value="PTHR34933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02107">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01008">
        <property type="entry name" value="FLGLRINGFLGH"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061748" evidence="6">
        <location>
            <begin position="30"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="200" mass="21201" checksum="AFBC0A4F0C1A33F4" modified="2010-05-18" version="1">MKICFRQGRGAALTALALCALLGTFLAGAADAASLWDDRTNWIVDVRPGRVGDVVTVLVNERTNAKDEATMDLKKSSSNSVSDGTGILKFIRALSLTSKNSSAGDGSFERKHHATATVACLVTEVLPNGNLVIEGTRDVRTSEETLQIQLVGVIRPQDVNSDNQINSSLVANAELAVKGRGAIARTQKPGIISQILQAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I5</accession>
    <name>D4M8I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type oligopeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_08990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.98"/>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-578-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061840" evidence="3">
        <location>
            <begin position="23"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="70"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="530" mass="59371" checksum="36AC5EAB05DFE7E2" modified="2010-05-18" version="1">MKGKKWFLALAAVLCLMGTAWAGEKEIVYNLSIEPRTIDPVLNNAVDGSNVIFNLFEGLVRIGFDDAPEAGCAEKWEVSEDGMSWTFHLRKGLKWSDGKPMTAEDFRYGFLRAITPENASPYAHLGFFIKNGEAFFNGKAKAEEVGLVAVDDVTFRIDLEYQTPLMLDYLSYHIFYPARADVIEADPRGWTSKPETALGNGPFMLADWQHNSEMTLVKNPHYWDADNVKVDKLRLVMITDSNTALAAFKGGKVDLIDSIPPQMTPQLIKSGEAKVAPTLGTSFSVFNVTRAPFDNPLVRRAFTLAVDRTVMAEKVAMGGQKPAVAFIPYGIPGVEPEKDFRAEGGAFLPDRADVEQAKKLLAEAGYPDGKGFPKVVYKYNLNPINKAIAEALQAMWKQNLGVEVELSNEEWKVFINTRMKHDFDIARHAYLVDFFDAGSLLELWQAGVPENVAGYANDEYDALIKDSLKQMDRAKRVEAMHKAEQILMQDLPVLPLYFYSTPYMQSARVKGIYMSPRKWVFFRGAEVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I6</accession>
    <name>D4M8I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases</fullName>
            <ecNumber evidence="3">3.4.17.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_09000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.17.11" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09000"/>
    <dbReference type="HOGENOM" id="CLU_021802_7_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-579-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017150">
        <property type="entry name" value="Pept_M20_glutamate_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037238">
        <property type="entry name" value="Carboxypeptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="184"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="380" mass="40448" checksum="4545F52B121496FC" modified="2010-05-18" version="1">MKDQEKRIFDWLSAHKEDIVADLLALVRSESPTGDKAAVDACGRVLASLYRDRLGAVSRTVPQTEAGDHLVTEVGEGERTLLIVGHIDTVHSVGSVPVRREGDVLYGPGVIDMKGGDIAVVWALKALKDLGLPLGKRVRIVNNSDEETGSESSRGLLLDSARGACACIVPEPATCPDGKVKPSRKGGGEIVVRCRGKAAHAGNNPQEGVDANVELAHQIIYLKGLSDYEGKGSTYSPGVISGGKAVNVVSDYAEATVDWRMCVPEEIPRTRSLLAERKAVLPGAQVEFEVRVGHPPLAENARNLALLELLKQCGADLDMRIEAAPMVGGCSDGNDISDAGVPTIDGMGMVGNFIHNPQEQLFLEHLVPRVALLASLILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J5</accession>
    <name>D4M8J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-only hydrogenase maturation protein HydF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_09190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09190"/>
    <dbReference type="HOGENOM" id="CLU_042017_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-588-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023873">
        <property type="entry name" value="FeFe-hyd_GTPase_HydF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041606">
        <property type="entry name" value="HydF_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040644">
        <property type="entry name" value="HydF_tetramer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18128">
        <property type="entry name" value="HydF_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18133">
        <property type="entry name" value="HydF_tetramer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03918">
        <property type="entry name" value="GTP_HydF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HydF_dimer" evidence="2">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HydF_tetramer" evidence="3">
        <location>
            <begin position="278"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="407" mass="43793" checksum="505874507DAB8CA5" modified="2010-05-18" version="1">MGLNDTPSGERVHVAFFGVRNAGKSSLVNAVTGQDLSIVSDVGGTTTDPVRKAMELLPLGPVLIIDTPGLDDEGALGALRVERTLRILAETDAAVLAADARRPLTEHDHRLLALLKERAIPFLIARTKADLLRPEERPAPGRDELCVSAVTGENVEELKERIAALARSVEDKKRLIADLLSPGDTVLLIMPQDGSAPKGRLILPQQQTVREVLDAHAIVVACQETEVAEALSGLTRPPRLAVTDSKVFARAAQDVPPCVPLTSFSILFARYKGNLAALARGAGRLSRLRTGDRVLIAEGCTHHRQCGDIGVVLMPGWIERYAGARPCFDFASGGDFPRDLSGVSLVLHCGGCMLNEREMQRRIGEAEAAGAPIVNYGMAIAQMHGVLRRSLELFPDVLKLMEEERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M1</accession>
    <name>D4M8M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_09630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.165"/>
    <dbReference type="HOGENOM" id="CLU_116157_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-615-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="140" mass="14863" checksum="8CA1F942D1D6F7D3" modified="2010-05-18" version="1">MADTAAAPEAAQQTTAVSPCGSLFGGGASAPSGEGGAAPQQQASLMGMLFPLVIFVVIFYFFIIRPQRKRQKEHESLLSGIGRGDQIVTIGGFLGTVKEVRDDTFLIEMGEGVRVRILRSAVQTKRTPAQGQPAAEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M3</accession>
    <name>D4M8M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_09650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09650"/>
    <dbReference type="HOGENOM" id="CLU_101003_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-617-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025490">
        <property type="entry name" value="RNAbp_HP1423"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038881">
        <property type="entry name" value="RNAbp_HP1423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="93" mass="10522" checksum="D2740FA976EDCA65" modified="2010-05-18" version="1">MRVDKFLKMARLVKRRSAAQEMAELGAVRIDGRPCKPASEVREGSVLEVAYMNRVLKARVLCAEEALLKRPGTVSWEQVEERPVSPDENPWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P0</accession>
    <name>D4M8P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09960"/>
    <dbReference type="HOGENOM" id="CLU_1298281_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-634-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="212" mass="24761" checksum="01934835C335376B" modified="2010-05-18" version="1">MEKIRLGELNKALRQCGIGLDLDEIDNTPCFGVYHVHDWNHGYDGFYGITVYEDGSYTKGTAGFHGTRRQFYRDMQETINFLLEYFRFKKIQELIIAPCFQYTQFSFNAERNDIYEEIYAFLRKNNVRKNERSGVKINLKDDIGPLEMTVEGAFRGVSELCLFAPTHKMLIAPNHHFGFTFFTQQKSLEMEVITELLGGYLNLLYLEDQESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R1</accession>
    <name>D4M8R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 2, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_10380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.248"/>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-662-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="338" mass="36624" checksum="B42839E51AEAC670" modified="2010-05-18" version="1">MKKLFKSVYPAALVFLFYVLVTLLRSMRVLNAYYIQVMMFAGINIMMTASLNLVNGFTGQFCIGHAGFMSLGAYGAAVVTTIVFHGKSIPAAAHVPVFLLSLLTGGCVAALVGALIGLPSLKLKGDYLAIVTLAFGEIVRAILRLIQPIGGARGMIGIPNYSNLAWILFFVTVTLYLLRNLIYSPYGRAFLAIRDDEIAADAMGINTTRYKIISFCIAAFIAGVAGGLYAHVLAFIQPDSFSFTKSSDFLVYLYAGGSGSLTGSVLGATLLTVLPEILRFLADWRLAVYAVILVVVMLYRSEGLCGGKELPFMRVSRASLYETPLFAAKRIREKRAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T7</accession>
    <name>D4M8T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Co2+ transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.296"/>
    <dbReference type="HOGENOM" id="CLU_089873_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-688-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061540" evidence="1">
        <location>
            <begin position="25"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="271" mass="29696" checksum="FB7C3FB114CA5D25" modified="2010-05-18" version="1">MRKFFSVMVAGALFAAFLGATAEAHEFWVNADYKDGLLKADLGYGHEFPDPEVIPDERTHLFEPLKLITPEGATEMALAGDKNYHYEVKADLKKGDYLVIGNYKPTFWAKGSEGWKQADKAKYKEMTKADATYAEEAAMYAKLVMNLDGADGTDLITKPVGQRLELVPQVNPATVKPGQRFPVLVLLDGKPAKTAEVKAVYAGFTGGAKDGDPANEYKCFWGRTGLDGIINIIPVKAGYWNAFVQVKIPYADTAVADETVLVSRLTFTIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U6</accession>
    <name>D4M8U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.309"/>
    <dbReference type="HOGENOM" id="CLU_2219276_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-697-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="106" mass="11209" checksum="ECC90741C5C3CD7F" modified="2010-05-18" version="1">MHEREETDYHNTFRLAERKAEAKGMTKGMAKGRVKGLAEGLAEGLAEGEALGEARGLAKGLNEGRADGIAATARRMLSMSFTSEQISQATGLSPDEVEALRSGTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U9</accession>
    <name>D4M8U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_11030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11030"/>
    <dbReference type="HOGENOM" id="CLU_028723_11_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-700-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="101" mass="11041" checksum="075177474DDBFD97" modified="2010-05-18" version="1">MYPTLRDGEAVVVDRNAYRQEIPDVGDVVLASHPFMRGVWMIKRVVGFAGEDRCVLQGDNAMESSDSRSFGPIPLRSIRGRATRKADGSPLSPPPTRGDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X9</accession>
    <name>D4M8X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_11490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11490"/>
    <dbReference type="HOGENOM" id="CLU_116636_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-730-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025455">
        <property type="entry name" value="DUF4276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14103">
        <property type="entry name" value="DUF4276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="114" mass="12839" checksum="613A09391873664D" modified="2010-05-18" version="1">MRQWVGNEPRFHPHAAQHDFEAWLLPYWTTIQKLALHDKAAPQGQPETIDHGKPPACHIKEIFEAGKRKKSYVKPRDAKAILRDNDLLIAIGQCPELKAFVNTLLVLSGGQAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y3</accession>
    <name>D4M8Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane proteins related to metalloendopeptidases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M23.014"/>
    <dbReference type="KEGG" id="sbr:SY1_11570"/>
    <dbReference type="HOGENOM" id="CLU_029425_5_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-734-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="215"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="35452" checksum="968B2069CF4CB200" modified="2010-05-18" version="1">MSALGSEKNSGAASDGSSREAACGAGWRALARCAALFCLAASLWGGPAWGAAFVSFPTSWDVGQAFAVSITSDADYDAPTVTWLKRTVSLDVEPGGDGRISYALLGSYVRDVKPGEYPILFEFTQGEQRFHVKGKVALRARKYPQERLRVSPKMVSPPKGELARIKREAALAARAKGTMTVQRKWTTPAQKPLDMMKVTSSYGFQRVYNGTPRGYHAGTDLRSAVGTAVRAPFAGTVVLVGDHYYAGGSVYVDSGNGVVSVFFHLNESLVKVGQRVARGQVVGRSGRSGRVTGPHLHYGLCLAGQYVDPMPLFETSVTQLLKRAGRAKVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z6</accession>
    <name>D4M8Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11800"/>
    <dbReference type="HOGENOM" id="CLU_167443_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-749-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="89" mass="9865" checksum="003944F67976E662" modified="2010-05-18" version="1">MSESTGARHYVLFPDVKNAQSLYELMKAAGVRCTFAPTPREADRCCGLAVLYQDAGERGRIERMAAENGVQVLRFFDGATGDPDRMKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M906</accession>
    <name>D4M906_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11930"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-759-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="242" mass="26567" checksum="E8E44F214E80D3F9" modified="2010-05-18" version="1">MTSSNKLLETRGLTKRFPRGVGDFCAVDHVDFTLCEGDFGHIVGRSGSGKSTLVNLLSGLLAPFSGETFFDGLPLPYGDDAAMAHLRNEQIGYVPQDAHLLPHLSVWDNVRLPLYLDGGLPNKEGVDGGERHALELLDRMGIAARRDAFPWELSGGEARRAMLARALLKGPRLLIADEPTADLDVLTSHEVMEEIRRVHSEGMTVLMITHELELLNYGTKIWTMEDGRLTEGQNLVVPKGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M936</accession>
    <name>D4M936_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopolymer transport proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_12290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12290"/>
    <dbReference type="HOGENOM" id="CLU_053325_4_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-789-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="72"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="207" mass="22748" checksum="0D13D8F458A328C4" modified="2010-05-18" version="1">MLEYMRAGGGIMWIIALLSFVALAVVLERLFFFTRSRTDPGRLEVGLGRALRDGDLQTALALAEAGNSSLHRLFAAVFSCWELPDETVRLLAERRIRRELYRWERHLPVLEVTARVAPLLGLLGTVLGMVEMFRSLHQGGAVDAIAVTGGIWKALFTTVAGLVAAIPMVLAHSLLQGAVDSQAETLERGVDFLLRERAVREAGRPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D4M943</accession>
    <name>D4M943_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12440"/>
    <dbReference type="HOGENOM" id="CLU_221880_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-796-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="23" mass="2585" checksum="DA46C8292E7B297C" modified="2010-05-18" version="1">MIAANISVLEELRALKRTLQDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M972</accession>
    <name>D4M972_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_13070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13070"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.536"/>
    <dbReference type="HOGENOM" id="CLU_076609_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-826-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="210"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="294" mass="33133" checksum="D6EE53C689772157" modified="2010-05-18" version="1">MFLSMTGFGRASRDFPWGSVTFELTSVNHRYQDFSTRLPREFASMEWRFLSILRAGLNRGKVRLSAEVAWAPGVRTPTLDEEGLLQFFRRVQSLARGQGLTAPADLTPFLVLPGICELGGAAAAEVQEAPEVWDDLLRAALDSLMEMKRTEGEKMRSVVAGDLEAFEDIVRGLEERWRTAAAAALESLRARIERVAEHFELEVDEARVAQEISLLSDRWDVSEELARLAAHVERFQETMDGGGLAGRRLDFLIQEMNREVNTMGSKVADAEFRWGVVEAKSCLERIREQIQNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A8</accession>
    <name>D4M9A8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_13640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13640"/>
    <dbReference type="HOGENOM" id="CLU_107131_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-864-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046272">
        <property type="entry name" value="DUF6305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19823">
        <property type="entry name" value="DUF6305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061545" description="DUF6305 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6305" evidence="2">
        <location>
            <begin position="32"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="194" mass="20565" checksum="6CB855CB14C8079F" modified="2010-05-18" version="1">MKKIGLLAILLLLVTAGLAYAELEGAEPPQGQEPLLITNAGQGPGGKMGRLLVTRAGVVNDLTYNAEPKPEDLESGGYKTVLVVIGSSAKGLGASGITIDQEIERLNALMAKAKELNLQVIAAHIEGKARRGKPGSADERSIDAILPFASHIVVNREGDEDGKFTKFAEEHNVPITYLKSAMELNAFAKAMYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B8</accession>
    <name>D4M9B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_13790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13790"/>
    <dbReference type="HOGENOM" id="CLU_062584_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-874-MON"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027024">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027386">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061214" evidence="3">
        <location>
            <begin position="43"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="344" mass="36661" checksum="40DBDF52737DD21C" modified="2010-05-18" version="1">MKRKVSMKRRVAMGFFAWARAFAGLFVAAAVLAPLLAAPAHGAEAGGERPVRVLCLKGPTGMGLARLMEEAEAGRTENRYEFQLAVSPEDLMARFVQGAADVVAMPSNMAAILWNRTQGGVRVLSASTLGVLAVVEKGDAIHGMGDLRGRTILASGRGASPEYVLNFLLRSNGLEPGTDCKVEWLSEHAAVVAGLAAGKGDAALLPHPFVEAAAMKVKGLREALDLTEEWRRLDLGSELVMAVNAAGRDYVDSHGAEVAAFLREARSSAEWVNAHPAEAARFIVKHEVLEDAGIAERAIPRCGITALAGAEMRRALSGYLKVLFDADPRSVGGVLPDETFYYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C3</accession>
    <name>D4M9C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HemK family putative methylases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_13870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.624"/>
    <dbReference type="HOGENOM" id="CLU_018398_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-879-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="290" mass="31832" checksum="04EFBFAC80396DDF" modified="2010-05-18" version="1">MSAGSATLRAHLTSIRKRLAAAGAVNAVQEARWLLCDGLRLTSAELLAHLEREVVLPEALEAGVRRREAGEPLQYVLGTADFWGRDFRVGPGVLVPRRDTEVLVRAALTSSRRTRPSRSWTGARAAPASPRRSSWSAPLARGILAERSPDALRWAAENLARWNLSSRARLLPTDAPEDIAVRGECDLLISNPPYIPRGAIPRLMREVRDHEPHLALDGGVDGMDCYRALLASAPAWLKPGAFVILETGESDQARAIRDAVERSPDRAFSFLQRIADDSAILRCVVLKYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D6</accession>
    <name>D4M9D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_14210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14210"/>
    <dbReference type="HOGENOM" id="CLU_2381962_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-892-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="94" mass="10738" checksum="F4A084825A78F786" modified="2010-05-18" version="1">MEEATRDDLLYGRLRLWQPAAGPRVSMDTVLLAAWVRRRARRPRFVELGSASGAVSLMLALRFPHRSTWWGSNFSRSSWSWRSATGLKTAFRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F2</accession>
    <name>D4M9F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="12" type="ORF">SY1_14620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.701"/>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="425"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="644" mass="72016" checksum="C8E71A7E53341356" modified="2010-05-18" version="1">MDNRTQGMQSAINDYNANKIKVLEGLEAVRKRPGMYIGDTGPRGLHHLVNEVVDNSIDEAMAGFCTRIDVTIHKDESVTVQDDGRGIPTDPHPSNGRPTCEVVLTRLHAGGKFEQGAYSVSGGLHGVGVSAVNALSEWFEVTIARNGMERTQRFERGVPVTDLSEGVPVDWQGTRIHYLPDKEIFEDVHHSLETLKSRFMELAFLNAGVRIFVTDERSSESREYHFEGGVSAFVQYLNRDRTTLFAPPVVISGERNDIKVDMALQYNDEYQERILTYANLIHTVEGGTHLMGLRQALTRALNEAARSGKLLNDKEDNLTGDDLKEGLTCVLSVKLVEPQFEGQTKTKLGNSDVRGAVDSVVYEGLLSVIEERPDIVRPIVDKALRARRAREAAKKAKELVRKGAMTGMNLPGKLADCSSKTPENSEIYIVEGDSAGGSAKQARDRTFQAILPLRGKILNVEKAQEHKMLQNREIQTIITALGCGIGTEFNATRLRYHKIIIMTDADVDGAHISTLLLTFFYRHMPELLTEGYIYLAQPPLYRVQRGKQVHYCYTEKELRQHVDGAPDPDKVGVQRYKGLGEMNPEQLWMTTMDPANRILKKVELDDDLLADEYFDILMGERVEPRREFITTNANSAKNVDLYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H2</accession>
    <name>D4M9H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_14900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14900"/>
    <dbReference type="HOGENOM" id="CLU_1136752_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-928-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="244" mass="26925" checksum="575B5B343F57EF97" modified="2010-05-18" version="1">MEKRMNTGRRRSGGWARRRRGFILVMALIVILVGAALTVGMLVLTEGFSRGSIFQRMAYEQHIDVANEVKRIEAFLIKTNQDRYEGGGRVLHGQGYTAADYGNPIKRLEDLQVTEHPDVLSTDRTEGNQRLVVQVYDANYRIEDLTKDLMEHPAKLRSFPPSLLPPSFSGTGSSSSPDGSTTDPSVSGGGGSVQVSVSQEKIYGVFGAYLLRVQLYTRKDGSAPWRFQRSAEEGFFAVASSDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I2</accession>
    <name>D4M9I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar (Pentulose and hexulose) kinases</fullName>
            <ecNumber evidence="3">2.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.17" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15050"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.764"/>
    <dbReference type="HOGENOM" id="CLU_009281_3_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-939-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="266"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="496" mass="52644" checksum="3540E8D005A2441E" modified="2010-05-18" version="1">MNHYLCFDAGTQSVKVAVYSAEGECVAKAVNPTTLLYPHPGWVEMDVEEYFQLTLTGMKDCAEQMGRKGLDPASVRAVMGDGIICGVAGVDEAGRAVTPYINYLDSRTREDAAALAALGTDLWARETGNPDPLCLFPALHARWLLKNAPSRGRVRKLMHNAPYILLNLAGLGASDAFIDWGTLSGWGLGYDVMEKRWSPEQLEILGISPSLLPHIVRPWDVVGGLSEEAAAQTGFPPGLPVCAGAGDTMQSLLGCGVFAPGHAVDVAGTCSMFCISTAGIVPDLSRSGNNLIFNSATLPDTYFYWGFVRTGGLALRWFRDNVCGQPGDDGCYDRLSQGAATVPAGANGVRFLPWLTGGPKGCEEVHGCFLNMTMDTDQFVLWRAVLEAIAGEYGEIADRCRAAGTPVERIIVTEGGSRSALWNQIKADLIRAETVTLDTGGALATNALLAAYAAGDVSGGEEGLEAALQQGLRETGRFAPGPAFALPPLPNGIFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I9</accession>
    <name>D4M9I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15140"/>
    <dbReference type="HOGENOM" id="CLU_1632992_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-946-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061555" evidence="1">
        <location>
            <begin position="28"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="162" mass="17908" checksum="27AF85AA6EFA0198" modified="2010-05-18" version="1">MKGLKRRVERGALAAVLALCLAGRAAAQLAEPVQASTEDLLQMTEESLYADWEENRAFVRGVGRVVQNTAQGRLLARRAALTDARRGLLLLRGHILEDPALRERTLWLSGPVPPVRILSERIEGGLYFIEVETALSRLLNKNGGIYVAGEMQRLKRNNAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9J1</accession>
    <name>D4M9J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YeeE/YedE family (DUF395)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_15190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15190"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.777"/>
    <dbReference type="HOGENOM" id="CLU_064908_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-948-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026366">
        <property type="entry name" value="Seleno_YedE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04112">
        <property type="entry name" value="seleno_YedE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="224"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="367" mass="37890" checksum="D0E84CFEC21A39AE" modified="2010-05-18" version="1">MDKLLTSRNGPWIAGGIIGLIAVLLVKFGNPGNMGFCVACFTRDIAGALGLHRAAVVQYIRPEIPGFILGAFLSSLLFREYAPRGGSSPAVRFVLGICAMFGALVFLGCPWRAYLRLAGGDWSAVYGIGGLIVGVLIGIGFLWNGFSLGAAERTPKGAGLAMPVLALGILALLFLKPTIESVGADGAKAVTSLIFFSEKGPGATHAAPLISLAAGLIVGWLAQRSRFCTVGALRDLFMMGDAHLFKGIVAFTVVAFAANYGFGFFKPGFGNQPIAHTNETWNFLGMVLSGLAFTLAGGCPGRQLIMTGEGDNDAAVFVLGMLVGAAMAHNFSAASSGAGLGPMGIPVTIAGLVFCLAVGVLFRPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P5</accession>
    <name>D4M9P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16060"/>
    <dbReference type="HOGENOM" id="CLU_1072645_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1002-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="259" mass="28120" checksum="CA627C9CADCAC54E" modified="2010-05-18" version="1">MLPLLILVSGLLLALYVGRFIFRRLRLKGRGKFLSGFIAVIVGPFVFFVYVGSLANVAMLKEQGPSLSKDAVLDSQKVSSETKPADVTILDLPEEPQEEVQDESVVPLLGCDSKTFQKKFNQAAKTFKSNLRCETLKLETGAVNDSFIASVTENIALIGSIDKKTQQLQSVTMIAQGDGTMHSGANIMLGIGQLIMATAPELDAKGRGQLLKDMGLTPENLEDGKEGRHVIGNKKFFFSMSDLIGLWFGVEAVEPKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P8</accession>
    <name>D4M9P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16120"/>
    <dbReference type="HOGENOM" id="CLU_3043696_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1005-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="54" mass="6059" checksum="F383BB367DABB6E2" modified="2010-05-18" version="1">MLAISLCTGFSAVALLCVLELLLAATEQEPPRWLDYVDGPYVRTKYTALKGRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S8</accession>
    <name>D4M9S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycine/sarcosine/betaine reductase component B subunits</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16570"/>
    <dbReference type="HOGENOM" id="CLU_887833_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1035-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050485">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015417">
        <property type="entry name" value="Gly_reductase_pB_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09338">
        <property type="entry name" value="Gly_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="313" mass="34536" checksum="8817CB6DBF079CE1" modified="2010-05-18" version="1">MRLELHKVKVKDVQWGSATCVKDGVLYVNKEEAKALIAEEDRFARVDLELARPGESTRIIPVKDVVEPRVKLDRKGYYPGFNNTAMARCGEGRTLVLDGAAVVTCGPIVAFQEGFIDMSGPGAVYTPFSATQNVVLVVEPIKDLEQHQYEQVLREAGLKLGVYLADKCRDAKPDVVDVFEKGTVPEEKEKHPNLPKVIYVCMNITQGLLHDTYVYGADIRPALPTLLHPNEVLDGAMVSGNCVSACDKNTTWPELADQLPAVQRVQKVDVARLPVEHLNGQPSLRHKEARRPLIGVAAVLQPQLLQRNFASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9T9</accession>
    <name>D4M9T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16850"/>
    <dbReference type="HOGENOM" id="CLU_3429804_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="19" mass="1962" checksum="3DFAB68027C92E46" modified="2010-05-18" version="1">MPEAAQRGTGAKELEVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W2</accession>
    <name>D4M9W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17310"/>
    <dbReference type="HOGENOM" id="CLU_2553341_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1069-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="82" mass="9346" checksum="07CF93271CE3F767" modified="2010-05-18" version="1">MLLPKDFVSTMSDEEQDRIMDEAYALEDRGEKEEADRLWRTLPVDPIFADGIKRTLGIGILKEGGYNLNDAVKLFGQEWLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z1</accession>
    <name>D4M9Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_17850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1054"/>
    <dbReference type="HOGENOM" id="CLU_038034_7_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1099-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061041" evidence="1">
        <location>
            <begin position="26"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="50"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="336" mass="36814" checksum="148F2A2CD6C50907" modified="2010-05-18" version="1">MRNRFFAFVLCAAAALLLALSPAEAARTAYPVTIDNGDRQVTFEKAPERVVTNGDGNIIELMFALDLDDRLAGYAGFPEYGGQVAPDHRERLKKIPVAAPGYITLEVLLGQKPDLFLSGYQYGTSVPGDTSAGAITPDELEKHGVKCYNITESLIRVMKKPPVSLEDTYTDLRNLGIIFDVQDRAEQCIASMKERAAAVEAKLADVDAAKPIGVFIYQTWNAPDQPPRTVGAQAMPSALMKMAKARNVFDDIDDSYVKATWEDVVGRNPDVILILECGNANGAERKKLLMEDPVLQGVKAIQDDRVIVIRVEETYPGPRAVIGLEAIARALYPDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA16</accession>
    <name>D4MA16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_18550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18550"/>
    <dbReference type="HOGENOM" id="CLU_2568910_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1124-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="81" mass="9220" checksum="7E6E17AA1836D9A2" modified="2010-05-18" version="1">MNVAHMENVKTRKSLYRRIHALSEENLQSLVHYLNELESGEAQEPNEETVAAMRDVIAGRNLSKTYDNVDEMMKDLLGSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA23</accession>
    <name>D4MA23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_18630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1124"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1131-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="209" mass="23458" checksum="269169452DEA429E" modified="2010-05-18" version="1">MLEVNNVGFHYGGGPWVLKDVSLKVADGERIAILGPSGYGKSTLAKLMAGYERPAEGAVLWNGAPLPGRGYCPVQLIYQHPERALNPRWKMRQSLFEAGALDEDVLREVGIRPLWYDRWPIELSGGELQRFCVARVMRSETRVLIADEMTTMLDALSQAHIWNFVLNYADRNGMAVVAITHNRALAERVADRIIHIPELNHVQVDRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA28</accession>
    <name>D4MA28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permeases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_18730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1134"/>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1136-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="439" mass="46587" checksum="9660386C7F46EA04" modified="2010-05-18" version="1">MMSFLDRTFHVREAGSSVRTEFLAGLTTFVTMSYIVFVNPAILSKTGMDFNALVVVTCLSSALATFLMAVLANYPIGLAPGMGLNAFFTYTVVLGMQINGAPVTWQMALAAVFIEGAIFILLTLTRIREMVVNTIPKALKVGISAGIGFFIAFIGMKSVGIVVHNDATLIALGQIGDNVPALLAIVGLLLMAVLTAHRVHGALLIGILAVTVLAAACGITTLPDTLVSMPPSIEPLFWKMDFSLVREPDFWVVVFTFFFVDFFDTVGTLVGVCSRSGLLDDRGRLPRAKGALMADAVGTVAGAILGTSTVTSYVESSSGVAQGGRTGLSSVVTAVLFIVAIFFTPVVGIVPSCATAPALILVGVYMMMSLRDLDYDEWTDVFPAILGFTMMPLTYSIATGIEFGVVSYVLVKSLSGKFRDVSGLMTFLAILFALKELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA34</accession>
    <name>D4MA34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated RAMP protein, Cmr6 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18820"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1146"/>
    <dbReference type="HOGENOM" id="CLU_053305_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1142-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010172">
        <property type="entry name" value="CRISPR-assoc_prot_TM1791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39965">
        <property type="entry name" value="PTHR39965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01898">
        <property type="entry name" value="cas_TM1791_cmr6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="373" mass="41280" checksum="F9C44D70E9D04263" modified="2010-05-18" version="1">MQALRDALKDLSKGQNASLLLARYLRETKQGEDEDKEAAQRGRDDLFQAARSAVKDEEVQALYARAFEARKNALSACSSSRTFQTEGRLIAGLGGSNVLETGLTLNPLYGVPMIPGSSLKGLAAHYCSMAWGAGDERFRSPALDARTRPTRQAGAVYEVLFGKVPLTGKEEDAEAGYLRFYDAWLLPDSLPNSLCPDVMTPHHSGYYTGEGAPTDFDDPNPVTFLSVRGSFEVRVGCEDPDPEVRKKWEKLALRILGEAFERCGAGGKTRSGYGRMKWVKSKEEQQAETEKAKKAETEKRNLEAGFKHPIGEELTVRCDSVNKKGNSSFTIEGMEARFDPALKVEKGTEVLARIVRTEMKPKKAYILERVQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA61</accession>
    <name>D4MA61_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_19230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19230"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1188"/>
    <dbReference type="HOGENOM" id="CLU_021594_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1170-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="247" mass="26393" checksum="13061CB4CAAD502B" modified="2010-05-18" version="1">MLRAASAPLHELALGGTAVGTGLNAPAGFDVEVARAISGLTGREFRPAPNKFHALTSRDELVFAHGAMKALACDMMKVANDVRWLASGPRLGLGEIRIPENEPGSSIMPGKVNPTQCEQVTMVAVQVMGNDAAVGVAASQGNFELNVFMPVCIYNFLQSARLLGDSIASFDERCAAGITANRERMRANLHGSLMLVTALNPFIGYENAARTAQLAFREGLSLKEACVKLGFLTPQRFDEVFRPEAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA73</accession>
    <name>D4MA73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits</fullName>
            <ecNumber evidence="5">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_19360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19360"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1201"/>
    <dbReference type="HOGENOM" id="CLU_139698_5_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1182-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="65" mass="7114" checksum="8061FC8BD7FDEB5C" modified="2010-05-18" version="1">MAKASANVELCKGCQLCVGNCPRKAIIPLETVNKKGYEIIKVDQDLCIGCGICYKVCPDYVFTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA75</accession>
    <name>D4MA75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit</fullName>
            <ecNumber evidence="2">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1203"/>
    <dbReference type="HOGENOM" id="CLU_048564_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1184-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="51"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="252" mass="27371" checksum="D22EB8D7A7E1BA33" modified="2010-05-18" version="1">MPVFKKPESIIKAAGYCGGCGHGIIQRTIAESIEELGLQDKVIASVDIACAFWAQDALNYEFIAGPHGRCAAVATGIKKVRPDATVYVHAGDGCSYVIGLSETCFAAIRDVPITMIVVNNGTFGMTGGQMNLATTLLGDRTVSSKAGRRQDTMGHPVDMLKAIAGFDVEFLARGALYDPRHIDQTKQFIRKGFENQRDNKGFSLIEVLSPCPTNWKLTPVQSMKKIKDEIEKVFPVGVYVDRSAAREKEKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA83</accession>
    <name>D4MA83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19490"/>
    <dbReference type="HOGENOM" id="CLU_1756154_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1192-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061864" evidence="1">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="148" mass="16698" checksum="9FCFC5A5DCC75D03" modified="2010-05-18" version="1">MRKKMRTPRAFLVLCLLLAVAPAAAAKPDYVIRENFFVQMITDIFMNLGDYLGKTIQYEGFVLPITEEDFSDGPEKFAVVRIAICCGPDNAPIGFACIGKDAPPENAWVRVVGVLRERKLEGEEEPYPYLELQELEVLQKRGKEKVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA2</accession>
    <name>D4MAA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19910"/>
    <dbReference type="HOGENOM" id="CLU_118461_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1211-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="130" mass="13893" checksum="5F87ECBF4C9B10A0" modified="2010-05-18" version="1">MLNEEVKKLLKSAMWDLATCSADGPNVVPVAFKDVSEDGKLVVGDVFLDTTLKNVRENGRIAVSVYDPQSLQGYQVKGTAEYVTEGAVVDTFKAMVEKMFNGAATAKGALVITPAKVIVTTPGAENKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC3</accession>
    <name>D4MAC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_20390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1301"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1231-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="241" mass="26138" checksum="5955948741159F24" modified="2010-05-18" version="1">MSLLEVEKLNVYYGAIHAVRDVSLSIEEGQVVTLIGANGAGKSSVIRSIMGLTPSRAARMDLRAPDGEAVPLQGRSTEDRVKMGIALSPEGRRILPHLTAEENLRLGAWTRNDAAGVEEDLEHVFTLFPRLRERRRQKGGTLSGGEQQMLSVGRALMSRPNLLMLDEPSLGLAPILVEEVFDIIRAINAQGRTILLVEQNAWAALKIAHRAYVLEVGAVALSGTGEELLNDARVRSAYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF2</accession>
    <name>D4MAF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Selenium-dependent molybdenum hydroxylase system protein, YqeB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1348"/>
    <dbReference type="HOGENOM" id="CLU_082089_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1260-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017695">
        <property type="entry name" value="Se-dep_Mo_hydrolase_YqeB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03309">
        <property type="entry name" value="matur_yqeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="265" mass="27534" checksum="CFFEC48805A7A261" modified="2010-05-18" version="1">MLTVIRGAGDLATGVAMRLIRAHMEVVMLDTDHPTAVRRTVSFCEAIRLGETSVEDIHAFCAPDAERARAIASQGNAAVMVCPDGSVIKELAPDAVIDAIIAKKNCGTRITDAPIVIGVGPGFTVGADCHAVVETKRGHTLGRAFYEPGAAALPNTGVPGTVMGYAAERVLRAPCDGVILPRRQIGDLVRAGEVAAEVEGNPMICAIDGMLRGMLAPGTRVKKDMKAGDVDPRGATADCFRVSDKSLAVGGGVLEALLHLRGTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG2</accession>
    <name>D4MAG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="6 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SY1_21020</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SGP1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 14"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21020"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1361"/>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1270-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="3"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="17">
        <location>
            <begin position="354"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="16">
        <location>
            <begin position="502"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBL28857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="583" mass="62822" checksum="71FBF451DD806E47" modified="2010-05-18" version="1">MFVKIVCTIGPASENYDTLKAMADAGMNVARLNFSHGDYEGHEKKLKLVRQVERDVKKPIAALLDTKGPEIRTGRMQDGAIPLEQGSQIVLTGKEECVGTPKRIHVKYPLLADEVTPGQSVFIDDGSLRLEVERVDGDDVVCKVIVGGILKDTKGVNIPGADISLPALSEKDREDIAWGIQHGMEYLAVSFVKTRQDVLDVRKLVKSCGGAMKLLAKIETYQAVQNIEEIIDVVDGVMVARGDLGVEIPTEDVPLVQKRLIALCRSKGKVVIVATQMLDSMIRNPRPTRAEASDVANAVLDGTDAVMLSGETASGSYPVQAVATMRHIVDRTERELGMWGVPFHDEASVMGVPDAVSDAAVLISKRVQASAILSLTKSGSTAKMISKHRPMCPILGLTPLQQTWRELALWWGIQPVRLVEQNDVNVAAREAINKCLQDGLLTEGELVVITAGVPLGQPGFTNMVEVLTTGTVLLSGIPLLNKNTSGPVCIATTPQEALEKATPGCVLVVRQITEDYRPVLEKVGALISESGMLVADGNFLAVDYNLPCVIRVMDAFATLADGDVVTVDGTKGLIYRGKVRLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG7</accession>
    <name>D4MAG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidases/acylaminoacyl-peptidases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_21090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.071"/>
    <dbReference type="KEGG" id="sbr:SY1_21090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1368"/>
    <dbReference type="HOGENOM" id="CLU_008615_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1275-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="442"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="651" mass="72472" checksum="3E6F6A801BDE006A" modified="2010-05-18" version="1">MKRPVEQKDLLDFRFLAAPTFSPDGGKIAFKVSRADAESNGYIKDIWLLSLPSGEARRLTSSGCEECFCWSEDGASIVFASKRPSAADREEGKAVTRFYSIGIDGGEATPLFEVPHAVSAIRALKAGRYLLTANFDPVHDNPEDADFMIFEQVPFMANGKGYIGQRRVGLAACDASGKLSRLTPPTMDVARVELSADGDRALVVACDYKDVKPLENSVYVLDLSTGALRLLSGTLPFTFKCAVWSGESIVLTATDHKAMGVNENPKIWLLEDGEMRCLTPELDVSFGHAIVADTSYGCRDHEGAIAPSKSLGVIACSTDAFKSRLYALAQDGRLKVLTPSVSSVIDWDVHDDRIAYVAYEGLHLPELYLYQEGKERRLTSFNDAFFEEHRLSQPIHITFKAGDGWDLDGWYMRPVDAREGERCPAILNIHGGPKAAFGDIYNHEMQCWAARGYAVIYCNPRGGDGRGGEFSDIRGRYGDIDYRNLMDFADWCVKNLDFIDASRMGVTGGSYGGYMTNWIITQTNRFKAAVSQRSIANWISKFGGCDIGYYYVEDQHLGTPWRTPETAWRESPVAHADKADTPTLFIHSTEDFRCELNQGFQMFTALKVNGIEARMCVFKGENHELSRSGRPRNRLARLREIAGWFDRHLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK9</accession>
    <name>D4MAK9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name evidence="2" type="ORF">SY1_21900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21900"/>
    <dbReference type="HOGENOM" id="CLU_100552_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="153" mass="16877" checksum="8DC8302372A2171C" modified="2010-05-18" version="1">MKVLILAVGRSRERALASLAEDYLARIRPAGLVGVERTPDVPARSPEEAMAKEGQDILRRIRPRDRTVLLREDGAEYDSPGFASFLAAEMERAGGRLLMVIGGPWGTSDAVKARADTGLSLSQMTFTHEMSFLFLAEQLYRAFSILQGTGYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAP5</accession>
    <name>D4MAP5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ruvB</name>
        <name evidence="8" type="ORF">SY1_22480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1492"/>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="60"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="358" mass="39340" checksum="7915A29A051BB402" modified="2010-05-18" version="1">MSEDARTPIGAEDEGRFFSSPRAAEDATVRPRALADFIGQERVREKLRIYIDAARGRGEPLDHVLFYGPPGLGKTTLAEIIAQEMGGQLRKTTGPALERAGDLAAIVSNLEANDVLFIDEIHSMPRQVEEILYPAMEDFELHIVVGKGPLAKTIGLALPRFTLCGATTRLGLLTSPLRARFGIVEQLSLYTEQELARIVLRAAGVLGIRIAGDAAIEIARRARGTPRVVLKLLRRVRDVASVKGTGEIDADIADRAMNMLDIDAEGMDEGDRQILRAVVERFDGGPVGLGTIAAAINEEPQTIEDIYEPYLIQKGFLERTPRGRRATSNAYAYLGCPMRRRPDEELRLPFGAEQEEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT9</accession>
    <name>D4MAT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
            <ecNumber evidence="11">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_23220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23220"/>
    <dbReference type="HOGENOM" id="CLU_016950_9_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1400-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="152"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="255"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="388"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="458" mass="51264" checksum="BDA732456475B4F8" modified="2010-05-18" version="1">MALSPHIFREYDIRGDADRDLTDAVVETIGRSYGTWLLDRGFNRMSIGGDVRLSTPRIRAALTRGVLAAGVGVIDVGTLTTPMLYWSLHHLDLMGGIMITGSHNPPNMNGLKLCWDKATLWGDDVQAIRRIADSGEFRTGQGALTHQSIPDAYLSMLKSRFQPFHRRFRVVCDSGNGAAGPFTKRFFELLGCDCTELYGTPDGRFPNHHPDPQKRENLQDLIACVREAGADAGFAFDGDADRIGVVDERGEVIFGDRLMALYWREIMEEHPGAEVIIEPKCTMALAEEVERLGGRPLFWKSGHSVIKAKMREIGSPFAGEYSGHMFFADEYYGFDDSFYAAGRVLRILAKTGRKLSELMSSIPLYPTTEEARIDCPDEEKFDVVSRIREKALKDHQGLTHDGIRILYPGGWGLIRASNTQPVITVRCEGRSQEDLELIMADVKRRLLDEGLPDFAWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU1</accession>
    <name>D4MAU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23250"/>
    <dbReference type="HOGENOM" id="CLU_1473151_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1402-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061244" evidence="1">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="183" mass="20160" checksum="3366B93EEF2F4444" modified="2010-05-18" version="1">MMRKFAGVLLLCATVLTALSADAAPSSPWRKVIGARTVRLWVDAQFMDELVLNARARVDVTWLPRSLMRLLDRDGSAEDWVVAALSNYYASRKEAAERMRGHDVLALRYRAEKNWNFDPTALTVDGYRVTSEDLLGNASIRVVGELPSGTEGTLLVRVPSLKGGRRVHLALGPDSADLEAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU7</accession>
    <name>D4MAU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_23350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23350"/>
    <dbReference type="HOGENOM" id="CLU_019824_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1408-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="10"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="444" mass="46954" checksum="CBDC6390F11118BC" modified="2010-05-18" version="1">MIDFGTMTTLVSFLVGLLIGLPIGWVFIGATILGLTVTGTSAGFVANAFFHSLDSATIMAIAFFVFTGALINEAGLADRIVNFSYALVGRLKGGLTAVGIVASVFMGALTGSSVPCIAALIPLLVPKLEKFGYDRVYTTAILCSSSYLGYLIPPSVPAMIYCLLAGQSVAALFLATVFPGLLLAIGYAVLNYFVVDKYTVNSDETPELPATFSGALKEIARTGWLAIPALGCPLLILVGIYGGIFTPNEAGGVAAIYCLLVGWLAYRELTLERLRAALSSTIGTFGMTTLLLAGGTILTRYLTRQGVAQEVAMTMMSLFEGKAMILLMINAFLLFLGMFLDGIPILVLVVPLVLPLMQELGVNLVHLGAIMTVNVGIGVMTPPFAMSIFVGSRLANVPAAKLTRAMMPFLLYVSIPVLLLTTYIPFLSCWLPQVLLGASVVGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW8</accession>
    <name>D4MAW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_23630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1604"/>
    <dbReference type="HOGENOM" id="CLU_117621_6_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1430-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL29013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="66" mass="7169" checksum="A3F136BD54AA2129" modified="2010-05-18" version="1">MAQGTVKWFNESKGYGFITADEGKDVFVHYSAIQGDGFKTLAEGQKVSFEIVNGEKGPQAANVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX1</accession>
    <name>D4MAX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_23710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23710"/>
    <dbReference type="HOGENOM" id="CLU_3057936_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1433-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="53" mass="6138" checksum="F856FB1635A4E1EF" modified="2010-05-18" version="1">MAKFRCLECKKEFEAEANDSSKRCPECLGRYLELISGEMKRGKSWSAKSYSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX4</accession>
    <name>D4MAX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein, possible Na+ channel or pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1617"/>
    <dbReference type="HOGENOM" id="CLU_091659_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1436-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007563">
        <property type="entry name" value="DUF554"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36111">
        <property type="entry name" value="PTHR36111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04474">
        <property type="entry name" value="DUF554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL29019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="232" mass="24060" checksum="EF57097120446590" modified="2010-05-18" version="1">MEFLSGVPAGGTLFNVAAIALGGSLGLALGRFIPERLNDTIFHCIGLFTLCLGVGMGLKMQDAVAVLASLVLGALIGDWLRLDDRLNGLGDLLKARFHLAEGPFTQGFVTATLLFCIGSMAIIGAIDDGLRHDPTLLVTKGVIDGVASVFLAGSLGPGVLFSVLPIALYQGGLTLLAVHMAPFLTERLYTNLSALGGLMILGIGLNLLGLTKLKLCDLLPGLALVVLITVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX6</accession>
    <name>D4MAX6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">SY1_23830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23830"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1622"/>
    <dbReference type="HOGENOM" id="CLU_054212_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL29021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="322" mass="33703" checksum="69FA36249ED9D3D4" modified="2010-05-18" version="1">MTFPTVLCFALLLDVLLGDPHALPHPVVGVGRLIRFWEGRLYPGAGAPCAVVRGAGLCALVLLSTLVAAAGLLWAAGWDGGLAAAVEVYLLYAALAWRSLKDETMPVALALFRRNLPGARAALSRVVGRDTENLNEPSIVRGAVETVAENSVDGVMSVLFFAALGWAVGEGAGMVLAVWGFKAASTMDSMVGYENARYHEFGRAAARLDDALNFIPARLGGLAILAAGACLGMDAGEGMRVFLRDRRKHKSPNSAHGESAFAGLLGLRLGGDALYGGVPESRPCLGDGTRTPEAADVLRAHRLLDAASALFALLCALPFRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY7</accession>
    <name>D4MAY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
            <ecNumber evidence="1">4.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_24010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.1.12" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24010"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1648"/>
    <dbReference type="HOGENOM" id="CLU_042088_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1449-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008473">
        <property type="term" value="F:ornithine cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="36883" checksum="6E48E18F6336F30B" modified="2010-05-18" version="1">MEILYLSSKDIESIHLDDEEIIQAIEESLAAQGEGKTSIEPRVHINPNSEYNGHFNVLRGYIEPKRAVGVKVVGDYVYNYKKNLPSEMALLNLFDPETGAPYAVIDATAITSMRTGAVTAVGAKYLAKKKNKILGHLGSRGTAFWNVVLLDHLFDFDEIRINSKRQESMEAFAAQLEERIHKKITLTHSSQECLEGADIMVEATRLTEPQPLLKTEWVRPGNLVVPYGTICANEISLTDVMDKVVVDDWNQCKEGGKLGSLSPHVRAGKLTQKTLYAELGEIVSGKKPGRESDDEKILFWHRGLSTSDIALGQLYFEKATADNIGTKLFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ5</accession>
    <name>D4MAZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_24110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24110"/>
    <dbReference type="HOGENOM" id="CLU_039613_32_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1457-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="316" mass="35912" checksum="884649EB7621B5CD" modified="2010-05-18" version="1">MTNNQIRYIIETAQAGSINMAARNLFISQSALSNAIMSVEDEFNNKIFNRTSKGVTLTSFGKLFIAYITPINRQLMQLYAMRNANGSTAPLTFTVISNGFFYISDIIAALERRYRSSGINLAILEDYGGNMLEMIHNNSADLGVVRLWSCYRNNNLEQFSTMSLLYRPIAMLQIGVNISENNPLYGYEGQNITPDLLRNYPMILHESLHNGPYADILSRLGLPVPRNRFIVDSRATMYELLDVTNGYVLDSRNLESGAGPYETKHNRRWRFLPLENCTIYSEIGWLIDESTSISQVAKNFVSMLSNYLLRDITQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z4</accession>
    <name>D4M6Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00490"/>
    <dbReference type="HOGENOM" id="CLU_086503_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-20-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="138" mass="15844" checksum="BE8C2FF622F6FB61" modified="2010-05-18" version="1">MEDYLFYDSKLAVNARELQSLYRYTEWGHSRSVEGIQAMIDGTSLCFSARHDDKLVGFCRIITDFVYRASLWDVIVHPAHQGRGLGGALADYALTHPAIRNIPIVMAYTTGWMRFLRGRGFETQRGLMMLMRCPIEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z7</accession>
    <name>D4M6Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00560"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1953"/>
    <dbReference type="HOGENOM" id="CLU_104115_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-24-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40044">
        <property type="entry name" value="PTHR40044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031501">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="162" mass="16403" checksum="8755E31CCF0144F4" modified="2010-05-18" version="1">MKTRTLASGAMIAALYAVLTVAVAPLSYGPVQFRVAEALTLLPLYLPEAVPGLFVGCFVANAFGGYGLIDMAAGSCATLLAAVLTRRASNLWLGALAPVLVNAIVVGGMLHLVAGAPLGLTALYVGAGEAGACFLVGIPLMRALIRQGILCGRHGAGIPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M717</accession>
    <name>D4M717_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00920"/>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-44-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="190"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="402" mass="42974" checksum="AD2666A26471FD8D" modified="2010-05-18" version="1">MASEIMEKAQSIRNYLVECKRRIHRHPELGMHEIETAAFVRSELKKLGIELQPIDTPVGVVGIVRGQKDAPGRVIALRADMDALPIQEEAAVPDASEVAGVMHACGHDAHTAMLLGAAKILTSMPDRFSGVVKLIFQPAEETLGGSELMIRLGCLENPTVDVILGQHGIAEFATGDIAFREGPSMASSDTFSVTVKGVGGHGAYPHNSGADALLASANCVMSLQGLITRQFNAVDPVVLSICTFHGGTAKNIIPAEVTFGGSIRCQSPASRSRIRDVMDHMISSIVAGYNCTHELDYVYGVPPLVNDPDVVHAMRSAAAKLLGEEHVKTMSQARMGSEDYACYCEKIPASCFARLGIRQEGKEPTRFHSPTFVFDEEALPVGAGFFVQAVLELNGAIAGPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4M722</accession>
    <name>D4M722_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_00990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00990"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-49-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="238" mass="27705" checksum="EE7533583CEBC42F" modified="2010-05-18" version="1">MLKDGKRTMNKQVYLSLRSDILSGRYHDGQQLLQAELAEEYHVSRIPVREALMQLSSEGLVQIIPYKGAVVASLSIEELHEIFEIRYALESLILRYVVQNITEESAARVHNLLLESTQTPPERRSRKTNWEFHRALYEIAEKPRLLELIESQYNKIDRYVQMDITLPNVQENAFKSHDAILQACRVGDAVEATVLLHEHMVTALRRLDRFLQQEEVRAPDSNRSTTLFMPLINRRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M726</accession>
    <name>D4M726_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_01050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01050"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.375"/>
    <dbReference type="HOGENOM" id="CLU_019824_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-53-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="424" mass="45295" checksum="8D8F66F5D195E531" modified="2010-05-18" version="1">MIALMFILLAALTLLGMPIAFATGVSSLIFLLYQGIPLNVLSQNIVSGIDSFTIFSVPFFYLAGELMNFSGITDRIIDMAKALVGHMRGGLAQVNILASVFFAGISGSATADTAALGSILIPAMKKEGYDADFSAAITAASSLIGPIIPPSIGLVLYGVLAQQPVGKLLAAGILPGFVIAISQMVFTHYYSIRKNYPTSPRATFKQARRAILRGTPALMMPIIVVVGILSGMFTPTEAAAVAVLYGFFMGAVVYREASLRTTWSLLANVALNSIKVLLIIAFASMFSWVVTRAQVPTTVLNALLQLSSNRYVLLGLITLFVFIMGLFMIPSAIQVVVTPILVPIILKLGIDPIHFGVLLVFTTGIGSITPPVGVCLSLAAEIADTSYKDLVKTMIPIYIPMLIATLIIAYVPWISTFIPDYFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M728</accession>
    <name>D4M728_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tripartite ATP-independent periplasmic transporter solute receptor, DctP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_01070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01070"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.377"/>
    <dbReference type="HOGENOM" id="CLU_036176_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-55-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003060981" evidence="3">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="323" mass="36257" checksum="18E3768F514AE4EC" modified="2010-05-18" version="1">MHKKFVAVAAVLFLLLSFASSAFAAREIHYSTWASSGEAAYTGMEKFKELVEKGTNGELKVFLYPADQLGKTTEQFEQVQMGTIHMMSSGQPPMTEIEYLSLPYLVKNLDNWKLILNSDIGKEWNQKCLSDYGVRILGLLPRGPRVISANKIINTMDDLEGMKIRSPERDYYVDTLVAMGAQPTTMSFGEVYTSLQTGVVDGQENPIETIVAAGFHEVQKCIAMTNHINKPAFVVINEEFFGGLTEEQREILIEAQAEAEKLTQALMEQQQVELLKSIKDAGVTVTTPDLKPFIEATRKVRDVLGTKVWGEERYRKITEMAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M749</accession>
    <name>D4M749_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01410"/>
    <dbReference type="HOGENOM" id="CLU_030273_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-76-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="143"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="366" mass="39540" checksum="FF8F1DB9CC7DA80E" modified="2010-05-18" version="1">MSKIKNVKVKVVKVPLKTTWQTSLYATSTRAHCVVKIETEDGIDGYGEASPAAAFMGETAYTMEVIIAKYFKPMLIGKSVLDISGINDTMDRIFSGNTSAKAAIDIALHDAAGKALKVPVYVLLGGKCRDSFDLAWSMGFKEFDKSVDEAREYVKKGFKVMKLKVGKGVEEDAKLVGRLRETFGPNVPIRLDANQGFTPGDAIALMHRVVEFNPECFEQPVPKWNYEGMRHVREHSCGVRIMADESISSLHDVMNVIKNGCADFFNIKVGKVGGLYRACQVAAAVEAAGFQAAAGSNLELGIGEAASAHFITSQPAVCLPSDAFCGTGLHTENLIKTPLAMTPQGTFSCNNAPGLGVEVDENIFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M773</accession>
    <name>D4M773_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GSPII_E N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01740"/>
    <dbReference type="HOGENOM" id="CLU_879276_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-99-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSE_N" evidence="1">
        <location>
            <begin position="42"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSE_N" evidence="1">
        <location>
            <begin position="212"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="316" mass="34665" checksum="69CD5CD334AAF06B" modified="2010-05-18" version="1">MEVKRRKLGEILLQMKLVSPEELRLALEDQARSPGKRLGAILIERGGTTSQALTSALGRQFMLPVVKVANYGDVAARHAVPRELMESLKAFPLEFQEHGTVLLVAISDPLDVVTRNILRAKISFPIRFALAPEEDILEALREAVSDPPPPPPAPAPAPASFGAATPLSIKTLRAKHPLLGEMLLRAGVITQQQLSMVLVIQERARKRLGEILLSEGIITSSRLAEALSEQLKLPLLSLAEEEPEPEAIRLVPRNIAARLNLLPLRIEADGRLLIAMADPLDILAQDEVQMMVSGGIRIGVATQESIYQNLPRFYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M787</accession>
    <name>D4M787_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01970"/>
    <dbReference type="HOGENOM" id="CLU_1649653_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-114-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="160" mass="17742" checksum="85A96C8F63FB4343" modified="2010-05-18" version="1">MTTWSHDKQLEMLQLIKLSYEMTSTCLKGEGGHGGYVPSYTDDLGFTGAHFKNLDAMEGHDGHFHYTTRPRKLSAFLKYSEGPDSAVRRSLANKNKKGCRIGIDPATLLSVDRRRGLLCAYARPAFFKDCSSSRGSPVASAILVRSSPIRNRFRAVSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M793</accession>
    <name>D4M793_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02040"/>
    <dbReference type="HOGENOM" id="CLU_2600971_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-120-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="79" mass="8472" checksum="6C6D3A200F4A42AB" modified="2010-05-18" version="1">MLARRANISPSDAMKRTFRRGEDAVQGEGFAPPVNDASHRLRQIALGFLVLLGALAVLTGVPGWDILPKVFKAGIATLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4M799</accession>
    <name>D4M799_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_02170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02170"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1484"/>
    <dbReference type="HOGENOM" id="CLU_011142_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-127-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="826"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="912" mass="96835" checksum="FCA9D5215013A970" modified="2010-05-18" version="1">MVVMHNIPALSAYNTVNRTSSSLQKSIQKLSTGLRINSAADDAAGLAISEKMRAQIRGLDRAVSNSQDGISMIQTAEGALNETHSILQRMRELSVQSANDTLTQQDRGYIQLEIDQLREEITRIGNTTQFNKKKLLNGDAAVLWSSDNLNTKAIINGGLRQIDQFGQKKASEGNYKIDVRAEPGQAEVKKSDIFKIKHKDVITDVTLNAVAGAKGVSVNNVPAGDYTINKAAAAVTDTAPALQGAYNAKSFHASGAQLTFKKITAPVAGASDASITVAGVKINLTNLVKDDEPGKVRDKVVAALTTKEAKQEFAKAGYAIKLKESGTDKLDIVAVKTDGTDALGKGAGLIQYTPGAVTPADAIDVGDGTSGLDNTLVSIDDPAKKTLTATNTNAINTNANILFEVTNVNHDSDSVTLKATVSKLGVDGKTSTVTYEGIVLKGGEAPTNLGDKLGLGAAAAFTLKLEGYGSYGFEKGSKLVYNVSKGNDGADPKADVKLTVSGKQNQEWDGKWGTDVTRNSASYGLKSDLVKGKDISFKNYYLNEKTGEVMEGTVKLTLNDDFAATPTGELAKFHATYVGEVARGDVKLRDLDKFWDSQGVFSQKDAKTLTITQGDGKQTSVTLYANDTLKDVQDKLNAAIGVGLGQAKYVDGEGGKHFVDFVDTASGNSESVAGTFVIRSVVSGSAGTISFSGDENIINALSLNVIQDATESSYTVSVKDAHSGDIVASNVQITGNRLYGVVNPNVDVEFDAMAGVSAKWDSARKGFVYAAKDYSTTLHLADNTTVFQIGANEGEDMGINIGDMRAHALGLNAVLVTDRESAARSITIIDNAIDKVSTQRAKLGAYQNRLEHTINNLNTAAENLTSAESRIRDTDMAKEMMNFTKLQIMLQAGTSMLAQANQLPQSVLTLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B9</accession>
    <name>D4M7B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASCH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02410"/>
    <dbReference type="HOGENOM" id="CLU_051256_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-147-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="124" mass="13956" checksum="E2BCF71F9D279259" modified="2010-05-18" version="1">MKALSIKQPWASLIAGGYKTIEWRSWRTHYRGPLLICSGKTPDDIYFEFDPDEARQNWPLGVAVATVELVEVRPFEPKKDAEAAMMEEDALPSVQGFSWVLENPVVVPDTPPVRGKQGLFEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C3</accession>
    <name>D4M7C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02470"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1704"/>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-153-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="189"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="394" mass="41960" checksum="0B46D38075811976" modified="2010-05-18" version="1">MNLWKECEGLQDYIVGIRRALHQIPELGTDLPKTQAAVCAELDKLGISYKKNQGDSGLIGTIQGGKPGKTILLRADIDALPIKEDTGLPFASKHEGRMHACGHDNHAAMLLGALRVLNEHKAELAGNVKFVFQTGEEISRGAKVAIKEGVMDGVDAVFGTHIGSILDPNIPSGTLIVVPGCAMASFDRFVLTVKGTGCHGSTPEKGVDPITIAANIVLSLQEVIAREIAAPKAAVLTIGKIAGGFAYNVIPNEVVIEGTIRAFEDPVRQHLAKRIGEIGKGVAATFRGGCDFEMDWGAPPVVNDDAMAKLAGDTAKKVLGAENVITSMPAPNMAGEDFAYYLEKAPGAFMFLSSSNHEKHTDIPHHNPKFDVDEDVLYRGSAMFVGLVEEFLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D4</accession>
    <name>D4M7D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_02620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1739"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-164-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="243" mass="26435" checksum="2548B740C905414D" modified="2010-05-18" version="1">MADERTPILSVQDLSVNYGAIQALRGISLDVFPGEIVAVIGANGAGKSTMMNAIMGDVPRASGRVLLEGRDLPRRSHQVVTSGVSLAPEGRRVFAPLTVLENLRMGAFPLSDRSAIEEQERKVFELFPRLLERREQYAGTLSGGEQQMLAVGRALMARPKVLLLDEPSLGLAPIIINEIFKELTVINRKLGTTILIVEQNAKKALQLSHRAYVIQTGSIVKEGASKDLLVDPEIEAVYLGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E9</accession>
    <name>D4M7E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mn2+ and Fe2+ transporters of the NRAMP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_02830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02830"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1762"/>
    <dbReference type="HOGENOM" id="CLU_055818_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-179-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="401" mass="42370" checksum="EA560A1E63BCDFD5" modified="2010-05-18" version="1">MEQKSKKGTMQVLLGAAFLMATSAIGPGFLTQTTVFTQQLLAAAGFAILATIVVTAIVQLNIWRILCVSGLRAQDVANRVLPGLGYFLAFAVALGGLAFNVGNVGGAALGLNTVLGLPLHYGAVISAAIAIFIYLNKDLGKAMDYFTQFLGVLMIALMCYVAVKAAPPLDVVVKETLAPGTIDWMVILTLIGGTVGGYISFSGAHRLLDAGIRDVKDATRAAVNGILVTSVMRVLLFLAVLGVVYVVAGEDAVALDKNNPAADAFFRGAGEIGRRMFGVVLWAAGVTSVIGASYTSVSFLRTLFKVIDRNYRWWMIGFICVSTAVNVLVARPVALLILAGTINGLILPLALGSILLGAYKKEVVGPYRHSILLTLTGWAVVAFTLWMGVQALPNIMKIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G7</accession>
    <name>D4M7G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_03090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1786"/>
    <dbReference type="HOGENOM" id="CLU_000604_8_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-197-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="300"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="395" mass="43111" checksum="0518351DD8A22C3C" modified="2010-05-18" version="1">MYLRMVTSSLVRRASRLIIAVLAIAIGATILSGLVTIYYDIPRQLGREFRSYGANLIILPKGDARITREELVKVRDVLGSDRIVGMAPYRYQTVKINEQPYIIAGTDLPEAKKNSPFWYVEGQWASAEEPDRVMVGREIADTLNLSLGDAFTVQGVKYGHQAVASGQNLTAEENQKRDLASQNFSRRFSVCGIVTTGGAEEGFIFADVDMLDELVGDAFRCDVVECSVVADATQLASLSAKLEAEVPGALPRAVRRLTQSQDIVLGKLQALVLLVTVVVLIITMISVYTTMTAMVAERYREIALKKALGAENGLVMGELLGEGVFLGFIGGALGVWLGFEFAQRVSLNVFGRAINFQWSLIPITIAVFIAVTVLASILPVRRVMDIHPAIVLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7I2</accession>
    <name>D4M7I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1816"/>
    <dbReference type="HOGENOM" id="CLU_1459305_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-212-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="185" mass="21067" checksum="52DD29E2465A163F" modified="2010-05-18" version="1">MALQASLLLIGLMLLYASGKSYWNIERSGIPKIVDLKTLYATSSEYARVTAKLKDTGIHIPKDEHDSESYFYVIELEDKLVLIESLHKQKEGRAHTFFVRPHPYEGTHVEMYFSVLAAASNRPVRDVRAEYADTMLQYFEDNPKTYNVILLLIGALLFGSGALWTIKARNGKAMIRAIFTFKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7I3</accession>
    <name>D4M7I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_03430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03430"/>
    <dbReference type="HOGENOM" id="CLU_2034670_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-213-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="121" mass="13877" checksum="CAD18506CCA638D1" modified="2010-05-18" version="1">MTAFKRDLMSWSRDDLLLMALTAYFEGMDLTRQERRVAVMLAESKSAKEICATIFITENTLKYHIRNINRKLGIKTRREIPALLAALTSEAERKGWLRRPAKVVSLAEFRARRGLQPAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7I8</accession>
    <name>D4M7I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03500"/>
    <dbReference type="HOGENOM" id="CLU_2002846_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-218-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="129" mass="14494" checksum="066C5FB6D92EAD63" modified="2010-05-18" version="1">MALITCRLCRKIFTAAAGRVCPECQKRLDDLYLDVRNYLRDNPKVAFNVETLADALGADIRDVQGLVDLGYLERDLPRGGELQENDSRQKLAKEFEQSLTQMRAAAAAAAQRKPVSYGQELYSDKGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J8</accession>
    <name>D4M7J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoacyl-histidine dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_03670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.13.3" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03670"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1848"/>
    <dbReference type="HOGENOM" id="CLU_028526_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-228-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="PTHR43501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016599">
        <property type="entry name" value="Xaa-His_dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01893">
        <property type="entry name" value="aa-his-dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="481" mass="52117" checksum="37903246CCAEC0C8" modified="2010-05-18" version="1">MMTLDALRREPVFRHFYDICQIPHGSGNERALSNHVLAWARELGLEAERDAVNNVLVRKAAAPGREAAPGVLLQAHLDMVCEKAPGVEHDFARDPIRWVLERDLLSTGGCTTLGADDGVGVAMAMELLQDDSLEHPALEALFTVAEETDFSGALNFDAGKIRSHFLINLDHAEGDSLLCGSCGGMRADICLPVTAEPLPAGFAACRLAVSGLRGGHSGEDIHRGHGNANVLLARLLMVAERRGARLASIRGGSFRLAIPRDAEAVVCLDPAEEPALREDLAALAEDLSRELAVSGDEVRVTLEREPEAPAAAAEPGPVISALVLTPDGIFQMNEMLEGLVDTSDNLGEVRFDGRELRLTLELRSARDSLRTYLYQRMERLAGLLGGSCRCDDLYPGWEFRPRSPLRELCVGAYEALFGAAPRVLTAHAGIEVGCLLQRRPDLDAVAIGPDAWGFHSPSERVSVPSVRRTHRYLRRVLSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L0</accession>
    <name>D4M7L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_03910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03910"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1869"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-240-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="330" mass="36863" checksum="831043E9108241A1" modified="2010-05-18" version="1">MTQTTRGRVPLLRVERLCRYFRLPGGRTLKAVDDVSFEVFRGETLGLVGESGCGKSTLGRTVLGLHPATSGSVLFDGLDVHAARGADRLRFKKRAQIVLQNPYASLNPRMTVGDIVAEGLDAHRLCRDKEEREERVCRLLTRMGLRPEFRSRYPHEFSGGQCQRIGIARALAVEPEFLVCDEPISALDVSIQAQIVNLLVDLREDLGLTSLFIAHDLAVVRHISDRVGVLYLGALVELAETDRLYGEPLHPYTRALLSSIPDVDPDNPMNARRVRLKGEVGSPIDFQCGCRFAPRCPQAEERCRQFRPELREVSPGHLVACHREEPFAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L3</accession>
    <name>D4M7L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrrolidone-carboxylate peptidase</fullName>
            <ecNumber evidence="9">3.4.19.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyroglutamyl-peptidase I</fullName>
            <shortName evidence="9">PGP-I</shortName>
            <shortName evidence="9">Pyrase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcp</name>
        <name evidence="12" type="ORF">SY1_03950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C15.001"/>
    <dbReference type="KEGG" id="sbr:SY1_03950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1872"/>
    <dbReference type="HOGENOM" id="CLU_043960_4_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00417">
        <property type="entry name" value="Pyrrolid_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029762">
        <property type="entry name" value="PGP-I_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00504">
        <property type="entry name" value="pyro_pdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 11">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL27858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="216" mass="23248" checksum="1319574295F3444E" modified="2010-05-18" version="1">MQNKVLVTGFEPFGGEPVNPAGEVLKLLDGKRLEGCQIVTQEIPTVRFLSLESLRSAVTREDPIVVISLGQAGGRSEITPERVAINVDDFRIPDNGGNQPVDEPVIEGAPAAYWSTLPIKSMVRAMRDAGVPASVSNSAGTFVCNHLFYGLMHFLATEGNARRGGFVHIPYMTEQARRLGEGNGLPVATMALGIETAIRAALTVREDLRETGGRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M8</accession>
    <name>D4M7M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_04170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04170"/>
    <dbReference type="HOGENOM" id="CLU_1765367_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-259-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="147" mass="16349" checksum="C3933BC5E581978C" modified="2010-05-18" version="1">MTEDSYTALEAYTTVTGMRADSLPDIAERIFLQDRPDGPQGYYVRREDGRETSWLSVRWTDKEAGKVNVDMEANLVLGPKDVESRYWSGEGTVRKGVLKADGDYDGQGSATFTFKGDSVQVVVSEDIAPDVDVTLDGTYVRQRLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q6</accession>
    <name>D4M7Q6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="15" type="ORF">SY1_04740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04740"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1967"/>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_0"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="13">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="14">
        <location>
            <begin position="177"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBL27901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="332" mass="34911" checksum="4BFABD0429B57A14" modified="2010-05-18" version="1">MRFAVLGAGSFGTAVANSLARRGLETVLWCRDPEQAQVIASVHRNPRHLKGYGLAPSLEATPDMAAALATASHVITAIPTQSLRDVLERVRGLPVEGKRFLSLSKGIEITTGLLPHRIFAEVLPGASLAAMSGPSHAEEVVRDLPTAVIAASEDLEVAMDWQARMNSPHFRVYTSGDVLGVEMGAAVKNVIAIAVGVACALELGDNARAALATRGLAEIMRLGVAMGANPLTLAGLAGVGDLMATCYSAHSRNFRFGLAVGRGKTPALAAEEVGEVVEGAHTVRALTAYARRAGIELPIAEGVFAFLYEGASLHEVIEGLLFREPKPENRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R3</accession>
    <name>D4M7R3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_04840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04840"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1976"/>
    <dbReference type="HOGENOM" id="CLU_101141_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-295-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="148" mass="16654" checksum="5D618761838E935B" modified="2010-05-18" version="1">MMEGRGAFVCRTRVRYGETDKMGIAYYGRYMDWFEMGRTEFCRAQGRSFTGWEAQGILLPVVEAHCRYKASLRYDDEIEIETAVVELSKVSVTFRCRVFRAADGKLAAEGYTRHAFTSTDGRLLRHGNALADWLGAMTAGAGACRTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R5</accession>
    <name>D4M7R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04890"/>
    <dbReference type="HOGENOM" id="CLU_2057965_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-297-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061738" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="119" mass="13492" checksum="736ACE1C74A4B45E" modified="2010-05-18" version="1">MNMKRITGRAILALLLASAIGAALALGADAASSARKRARLKNTPPPGWQFEVGYTLWRAQRGLDATPQTWKKYQRERKRLAQRGKLRGLDTRLLNSVDWTIEELAEFLEVQQEQMRADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R8</accession>
    <name>D4M7R8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="8" type="ORF">SY1_04930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04930"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1985"/>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="207"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="633" mass="68925" checksum="6F39D6937BBA6B42" modified="2010-05-18" version="1">MNKGQKFSAGYFLAALVLAWLFADLVYKPYMESRTEVPYSTFLADLENGAVDEVNLAAERIVYRLKAVSSDLSDRPVVGGIILDRSPAPVVRNVVRVLDPLLVEKLASADVTFGGVAQQSAILDTVLGVLLPFLPLLLLWYFIFKRMSGGSGSVLSFGRSKAQELQGEMTGVHFKDLGGVGEAEVELREIIDFLKEPERYNRFGAKLPKGVLLVGPPGTGKTMLAKATAGEAGVPFFFITGSSFVEMFVGVGAARVRDMFEQAKKKAPCIIFIDEIDAIGQSRALSMTGNSEQENTLNQLLAEMDGFTPNTGVVIMAATNRPEILDQALLRPGRFDRQIQVVLPTEEGRRDILQIHTREVPLDDNVDLKALAKVTPGFSGADLANIANEAALMAVRRKAEKVSAQDFDLAVERVVAGLQRRTPLTPAVRRRVAYHETGHALAACFLPGTDPVHRVSIIPTARGALGYTMQMPTEDQYIVGEAELQSRLAVLLGGRAAELLIFQEPSTGASNDLERATETARRMVTEFGMSSRLGPVRYAGRAMTYLHSEAESRTDLGSSTFEAIDEEIRRLVSKAQETAVELLKAHEATLHEAARVLQEKEAITGDEIREIIRRVEGSVPAEEKSADASLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W2</accession>
    <name>D4M7W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05540"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2046"/>
    <dbReference type="HOGENOM" id="CLU_024970_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-344-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_4" evidence="2">
        <location>
            <begin position="300"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="466" mass="53247" checksum="FD79E65FA3A2D9FB" modified="2010-05-18" version="1">MKDYREIVRELTAHPSEEEWFEFKENWYDAHGIGEYISSLSNSAAMNGKGNAYLIWGIDNVTHDVVGTRFAHRQDVKNEPLEHYLARQLTPDLNFSFHDVTLNRRRVVVLEIPAAKQSPVAFDNVRYIRIGSSKVNLSKHPEREAALFSVLKNGLPTTENTEADIQELSFRKLFFYYEDRGIVLNRRNFKKNLGLLTKDGTYNLLAQLLSDDSKIPIRVSIFMGRTKADPLYSVREFGNTCLLISLEKILEYGDVLNIMQADEKDRIVERREVPLFDQDAFREAVINAFVHNLWVTGNAPMFTVFNDRIEILSRGTLAPAQTLEGFYTGDSVPVNKRLSDIFLQLHISERSGRGVPKITQVYGREAFEFRENSIIVTIPLNRMLPAAGDRSGGKMGDNVGDNTLNPTRQRILAEMRNNPNITHPQLMRITGLGKTAIQNNVSYLRKNGYVERVGSNRNGYWKVCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W9</accession>
    <name>D4M7W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mg2+ and Co2+ transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_05630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2056"/>
    <dbReference type="HOGENOM" id="CLU_007127_8_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-351-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="327" mass="36922" checksum="712E3F847CCD7E8F" modified="2010-05-18" version="1">MISVLRTNTNQKNPGHEDLSLDTLRHGSWINLVAPTRQELEDVARIAAVPLDFLTAAMDVEESSRIDVEEADEDSGCDTSLLMVLNIPKHPESFSFDTLPLGIVITESAFITVCLEENVILPGAAGGVRGFCTWKHTRFLLQILYRTAGAYLQYLSEINRMSNSIEHTMRQSLQNEELFRLMDLEKGLTYFTGSIRSNRVAIDKLLRVLKNPQYQELVKMREEDEDLLEDVIVEHDQAYDMVRVYSDVLGDTMDAFASIISNNLNIVMKFLASVTIILAIPAAVSSFWGMNVRLPLMDSPNGFFWVSLIALALSAVATLWLWMRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X5</accession>
    <name>D4M7X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05750"/>
    <dbReference type="HOGENOM" id="CLU_105325_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-357-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061169" evidence="2">
        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="167" mass="17696" checksum="D160561F5D3E7AEE" modified="2010-05-18" version="1">MNASFKKTALLGLAVIAGLSGLLAQQADAHGVGYSESTLKPVSLEFFYSTGELMNYLEAKVFSPADEKIAYQSGRTDEGGRFAFTPNKPGTWRVIVSDEDGHRAEATVNVTEDFLKAGATGGGSGIDIQEKKAAPEGLDLLLRAGLGVSLIFNIAAFVLLLRCRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X9</accession>
    <name>D4M7X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS sodium solute transporter superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_05830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05830"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2073"/>
    <dbReference type="HOGENOM" id="CLU_018808_15_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-361-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="509" mass="54533" checksum="0F0E0C195473898B" modified="2010-05-18" version="1">MDVSTMLVPATGTFFLVLGGYFLIMALIGFYSARETKSLKEFFVMGGKAGAIVSGIAYFATQYSMSTFMGVPAACYRQGYPGLTVSVPGLVFSMIIPALVVGRKLIKLGHEQGFMTMADYLGDRYESNLLRGLQAVLMVFFMVPMMGAQIIGAGIIFNTFTGYPEWVGVVATGLIVIVYCMSGGIRGAMLTDVIQGLLMVVTAVVTFFVALDMGGGLEAINAKLFELNPAYMAHPGATGAYPWPALVSMVVMWSFFNIGSPTLATKFFTMKNYKVMFKAVILGTLGMWVSATLIEWVGVLGIVSVPGLEGKQMDFIVPLILQKGVSPVFASLMIAGIMAAGMSTIDSLLVVSSGGISRDIYQNLMNRNASDAEILRLSRVVTCVFGVVAILFGIWRPSAIFDIIIFSFGGLTIWATPVLLGLYWKRTTSAGAVLGILTGVLLYIPLSASPQILEKIGLGGLVEISSTLKGYTFGFNALIPTWVVAMIVTVLVSLVTKPVSEATLKRHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y1</accession>
    <name>D4M7Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05860"/>
    <dbReference type="HOGENOM" id="CLU_2422684_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-363-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="91" mass="10716" checksum="95892A07E1C41797" modified="2010-05-18" version="1">MKNISSVIVEYLERTMLNKGLVLYVSDEGKYMAMDESFNIRFKFDLEFSDRAFVCHTLIHNEGELQLCHSVNIAWTNGKAIRDFFQYLQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y4</accession>
    <name>D4M7Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, BadM/Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2079"/>
    <dbReference type="HOGENOM" id="CLU_107144_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-366-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="161" mass="17825" checksum="16D549705AB64195" modified="2010-05-18" version="1">MKLSTTTRYGLRALTDLCVQQQDAPVSVSDIARRQSIPVNYLEQLFAKLRRSNILKSVRGAQGGYLLARPAKEITLSEVIAALGEEILFGSCQSEKGCANAATCSTFDLWNRLRISIDGILDGTTLEDLAKKDRTLRARKTVDPLRRAAVARALKHQEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M842</accession>
    <name>D4M842_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_06760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06760"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2169"/>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-425-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="6"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="315" mass="33156" checksum="8CC0F090943603FD" modified="2010-05-18" version="1">MKYALCFPGQGAQQVGMGQELYRAFPSAKAVFDEADDALSAHLTKLIFEGPEGELTLTANAQPAIMTVSVAALSVLEKEMGVALKPACGAGHSLGEYTALVAAGVLSFSDAVRLVNKRGRWMQEAAPEGVGAMAAILGLGSDEVKALCAEAAPGGECQAANFNSPGQVVISGVKEFVEKAAAAAKAKGARKTVMLNVSAPFHSRLMLPAAEKLKEEFERCSWAEPKWPIVANVSASAVVSAEEIRDALYEQTFSPVLWESSVLYMVDYGVDTFLELGPGEVLCGLIKRCRKGLKQMAAGEPEALEAMATALREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M847</accession>
    <name>D4M847_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06820"/>
    <dbReference type="HOGENOM" id="CLU_2769891_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-430-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="69" mass="7241" checksum="B0A0734B4929B9CC" modified="2010-05-18" version="1">MEQVGQVRVESIFKVGVPAAEAGTAARTAARTAINSAFIIDTSFRSFGPAAVGFCAPGREVRFVKAILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M855</accession>
    <name>D4M855_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06930"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2183"/>
    <dbReference type="HOGENOM" id="CLU_034724_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-438-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008537">
        <property type="entry name" value="DUF819"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34289">
        <property type="entry name" value="PTHR34289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05684">
        <property type="entry name" value="DUF819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="399" mass="42123" checksum="75F58E06D6D1291E" modified="2010-05-18" version="1">MTSFIGADQTWVLFAILTAIAALSIQLEHNYRWASRVTGCVLALIGAMILSNLNVIPLDAPAYDFVWSYVVPLSIPLLLFNANIRRIWKDSGRLLVIYLISGIGTILGAFIGYFLLKDLVKDLGIAVTMMIGTYTGGSVNLVAMADAYKAPADLVSSSVVADNLLMALYFFALIAASGSKFFLKNYKHPLIDAVAARSDGDRGAASYWVAKPVALKDIASSVALSFVIVALSTVIADCFSAAIAKDSFAKALINGLLGNKYLVMTTVTVLIATAFPGFVGGIAGAQEIGTFLIHIFFTVIGVPASIRLIVTQAPLLLLFCTIIVATNMIVSFSVGKLFGFTLEEIVIASNANVGGPTTSAAMAISKGWTELVVPAILVGTLGYVLGNYYGVFAGTCLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M887</accession>
    <name>D4M887_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_07520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07520"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2241"/>
    <dbReference type="HOGENOM" id="CLU_018808_15_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-471-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="507" mass="53037" checksum="5B7ACBD47E5A40C9" modified="2010-05-18" version="1">MVMTEALSLLSNGYVLFILGYAVLLILIGALVGRRVTSAEGFFVAERRLGPALLFTTLTAANLGAGSTVGVSALAWRHGLSAWWWIGSAGIGSMILAFWVGPRIWRLAVRHNLYTLSDWLDLRYGKAFRGLLSAMMAVGTLALFAGQLLGIAWILQVAAGVPTTVGVVAGAVVTTLYFAAGGLFSAAVVNLVEVAVILAGFAAALPFIWSFVGGWEGLTAKVGQNLAEAERTDAYFSMGGMGTTAIVGYLVMLVPSFFISPGLIGKVFGARDERTIRWGTALGGVVQLVFAVIPVFIGVAAFACFPDLSRADLALPTAIKEMLPFSIATLSLAAIFAAEVSTADAVLYMLAGSITNDLYKRFLHPSLSDRGLLWGSRLVSLASGVAGVFLALRLESIISALTIFYSLMSVSLAAPLVLGLLTSRASTTGAILSAVLGVLLTLFCTFYSGTATVNLGFGVLDTATHLVDVGFARLNATTCGILLSFVAMGAATLLMPARRSAGERGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A4</accession>
    <name>D4M8A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_07800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07800"/>
    <dbReference type="HOGENOM" id="CLU_1182882_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-489-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="249" mass="27769" checksum="898CC2808D00E472" modified="2010-05-18" version="1">MSDKDRDLSVAGELLEVLRRSGRDFMTLSAMRKAMSSQLRKRLGLTGRNLTNPNVIKILTPHLEDKLAICSKGNAVYLLRGTNLAEVVLCFIRGKAGKSGPQLLNGMPFIKKDELIRILNNLLESGQVTLKLAAEFAPRFFASGAMGPVKKDAAGTACETLADTFDKRREQLHAAFRELDRGSTFVRICDLRGRLGWPREVFDDMLRRLRDDEAVQLHAGDVTLMTPDQVQDGFVDENGFRMGTMTWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B0</accession>
    <name>D4M8B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/panthothenate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_07870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2279"/>
    <dbReference type="HOGENOM" id="CLU_018808_15_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-498-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="485" mass="52416" checksum="EA812374B8AF63A4" modified="2010-05-18" version="1">MNTGVLSLGVIVLYLVAMLVITVVHGRRKKKASALDFFLANRGVNSILLPLTMIAAMQSTFAFLGSPGMYYTHGISFIVLVLSQVWVALMVVYFGNKIRLLANERGYMSLGDYLEDRFQSRYLKVMAACVSVLMTMIFLAMQYVGNARAMSVVSSGAISYNAAILVSVAFSLLYVLIGGAGGVVLLDAVQAVILLIGIVLAAWVALVPSGGIVNLFTQVRQTAPELLSRPGLKGLYTDKYWVMQFIVLPFGIWLCPHVWNKSLMARDEEALARSAISIPISQILIYGFSTLFIGLAGHILVSASEVRAADNILPILMLKYSNWFVAALIMAAAIAAGISTINAMLLVSSQLVSQDLILLTRRGRISNEQNMRISRIIVFAVAAICGLIALKPPATFVQVIQDVAYTGLAQLAPPFLLGMYWKRCSRLGASVGLTAGIAILFGTRILGVSPLGWPGFMWGFFINIILTVVISLLGKEGEAPTAEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D7</accession>
    <name>D4M8D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_08280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.26"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-526-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="120" mass="13155" checksum="73F6F5F57168C25E" modified="2010-05-18" version="1">MGKKVLIVDDAAFMRMMLKDILQKNNFEVVAEAENGKAGVAAYQKYKPDIVTMDITMPEMNGIDAVKAIKALDPDVKIVMVSAMGQQPMVIEAIQAGANDFIVKPFQPERVIEAITKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8E3</accession>
    <name>D4M8E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protease subunits, stomatin/prohibitin homologs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_08390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.35"/>
    <dbReference type="HOGENOM" id="CLU_027197_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-536-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="138"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="375" mass="43196" checksum="5F19A815C307F60C" modified="2010-05-18" version="1">MNFKEEKMKITVGENERAFLFRNGRFVRMLGTGKHRLFRFLGEEVRRLDVNDEPLNADIPLPVYLRDENFAREVETVRVSDGHVALHYVDGRFAGVLEPGEHTYWKVFRSHDFKLVDTEDDTATLPPLVQEAIPNSLCERVEVDAHEVALLYVDGRFERLLEPGRYFFWRNGRNIDWTPCDLRIRQVDVAGQEILTLDKVALRLNFVCTYRVLDPVRLYREQEDPERQLYAALQLALREVVGHLRFDELLERRNDLGSLVLEALPHDGIVEFVSAGLRDIVLPGEIREIMNTVLVAEKKAQASVITRREEVASTRSLLNTAKLMEENATLFKLKELEYLERICEKVGSISLDNASGILEQLRTMTALSGTKSDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8F8</accession>
    <name>D4M8F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_08630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08630"/>
    <dbReference type="HOGENOM" id="CLU_168121_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-551-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06088">
        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="RPL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="102" mass="11137" checksum="8925E71730C5000B" modified="2010-05-18" version="1">MDKPDGPLGPDPVSCRLGQVVRSTKGKDRGRLYVVVGFLDGNRLALADAERFNVLQPKKKNPRHVQVTPQCAAELVALIEAGKNIDRGRFCQILAGLGMRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G9</accession>
    <name>D4M8G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">SY1_08770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08770"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.74"/>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="100" mass="11599" checksum="E722DDA9A54D6587" modified="2010-05-18" version="1">MEPYKETAPAHRKVRVGIVVSNKMDKTVVVKVSRLAEHPLYGKRIRRAKKYVAHDAENTCRVGDEVRIRETRPLSKTKRWELVEVMRRAPVFDSDTPGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H7</accession>
    <name>D4M8H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ORF">SY1_08860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.85"/>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="207" mass="22076" checksum="9EDBE12CC872C0E6" modified="2010-05-18" version="1">MGIGILGKKMGMTQIFDAEGQAVAVTVIAAGPCPVVAVRTPEQNGYSAVLLGFGAVKPHKLSKPVKGLFDKNKVEPKRTLREFRLDKAEGYEVGQEIRVDLFEAGERIDVSGVSKGKGFAGVMKRYHFGGQQFSHGTSVEHRHGGSSGAISYPGRVFPGKRMPGHMGSDKVTVKNLTVMAVDLENNLLLVKGAVPGAKDGLVALYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H8</accession>
    <name>D4M8H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_08920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08920"/>
    <dbReference type="HOGENOM" id="CLU_168063_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-571-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="82" mass="8808" checksum="3EE4B0678EB17328" modified="2010-05-18" version="1">MPLNELAAGTRVVGEKEVLRALGRDGLRKLFVAKDVESERLRPLLEGARALGVEVEWADSRLVLGRACAIDRSASAAGLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M5</accession>
    <name>D4M8M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09690"/>
    <dbReference type="HOGENOM" id="CLU_3118144_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-619-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="50" mass="5534" checksum="909EC90152773444" modified="2010-05-18" version="1">MPASLRCSATARAMARMWASLKLRSLEEPRWPDVPNATCWDRASGSGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q0</accession>
    <name>D4M8Q0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoribonuclease VapD</fullName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_10120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cleaves ssRNA, mostly between U:A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the VapD ribonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10120"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.215"/>
    <dbReference type="HOGENOM" id="CLU_145265_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-651-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016368">
        <property type="entry name" value="VapD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002882">
        <property type="entry name" value="VapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="98" mass="11197" checksum="5E1E28336299363E" modified="2010-05-18" version="1">MSVYAIAFDLKVAELKKNYGDPYNGAYQEINEELKKAGFEWTQGSVYLSMKDGDNLTAVYKAINALSRIEWFKNSVRDIRAFKVEDWSDFTDVVKGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T9</accession>
    <name>D4M8T9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA-ATPase_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10900"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.299"/>
    <dbReference type="HOGENOM" id="CLU_021114_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-690-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="520" mass="59224" checksum="FA405E4D8509C59A" modified="2010-05-18" version="1">MKRNLKTLPIGTYNFEKLRRMNCVYVDKTARLVKLVEAGAWYFLSRPRRFGKSLTLSTLDALFGGKAELFRGLAAEAWAIEQAKHPAPVLRLDMSMMNVSDVAQFEGSLNSALTWRAEDAGVTLSSQQPSDKFQELIRALHRQGGPVVVLIDEYDKPILDKIGNLEAAEAMRDSLRTLYTVLKGCDEYLRFVMLTGISRFTKTGVFSAMNNLMDISMTESFGDVVGYTQEELERDFADWIDDTAGKMRLSRQELLMRMKDYYDGFCFDGTTRLYNPFSILNFFFNGRFSNYWYESGSPSFIVAYMKRHEILDPEAYRHLVVKESFASSQEIERARPESFLYQAGYLTIEKWEEQSLTLDYPNREVLDSIAGMYLEHVYNVEGYSSIGAQLWKALSNGEVTEAIRLYNTALASIPYQDLARRDESLYRSLFLMLLRGAGITAHGEVPTNRGRSDVLVLFPHRVVVLEFKLARSAGEIARLRDEGRKQIEEKGYAKPFDADRRAVTSAVVVIDLQKHEAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U5</accession>
    <name>D4M8U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion-translocating oxidoreductase complex subunit B</fullName>
            <ecNumber evidence="5">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rnf electron transport complex subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnfB</name>
        <name evidence="9" type="ORF">SY1_10980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 3 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10980"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.308"/>
    <dbReference type="HOGENOM" id="CLU_053470_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-696-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00463">
        <property type="entry name" value="RsxB_RnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010207">
        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01944">
        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="8">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
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        <location>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
    </feature>
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        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
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        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="277" mass="28322" checksum="96E9CE27CF8C8035" modified="2010-05-18" version="1">MNFMHDLIVPLVLMGVMGAVFGALLAIASVVFRVRQDERVGKIRAVLPGANCGGCGYPGCDSYADGVVNEGAGTNLCVVGGSAVSARVAEIMGVKAEETVPMRAFVRCLGSAARSPRKVLYSGIADCRSAVMVPGGSPNECPFGCIGFGTCTKVCNFDAIFMGPDGLPVVDREQCVGCGACVSACPKDVLTLIPQTSDVVVACGSHWKGPAVRRVCSIGCIGCGLCARVCPAGAITMDRDLAVIDPAKCTNCGLCAQKCPAKCIETGQSLAACAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W3</accession>
    <name>D4M8W3_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Ethanolamine utilization cobalamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
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            <taxon>Synergistaceae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11290"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="4">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="183" mass="20562" checksum="C805AC51D08C8939" modified="2010-05-18" version="1">MATGKQEHTTHLLGAEVVGKTHPRIELRGRLDELNARIILMQARARAAGERQLEADLEEVRVKAVREAMMAEVTDAPCGELALWGLTEEEIHQRSHTPARFYGKGHLDLHADMGLWAAEINLLRTLVRETELVACRAFDDGAGGVTRPDVVKMLNRLSSALYILIYNYLPEGFTRFYGRIGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X0</accession>
    <name>D4M8X0_9BACT</name>
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        <submittedName>
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        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">SY1_11390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Synergistia</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11390"/>
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    <dbReference type="HOGENOM" id="CLU_036176_1_3_0"/>
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    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061199" evidence="2">
        <location>
            <begin position="21"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="326" mass="35689" checksum="F542A8F0CBDCB712" modified="2010-05-18" version="1">MKKFLGAALLVLIAASGVQAADYTIKLGYIGSESHPTMTVMKDVFAKQIEEGSAGKIKVELYPNGQLGGDRELCEGVQLGAIQMAIPSSSVLAGFEKRIQVLDLPYLFTTREAAFAAVDGVLGEKLNGLTAEKGILILGYQENGFRHVTNNRNPIHTPDDMKGLKIRTMENPMHIAFFKALGANPTPMSWGELYTALQQGTVDAQENPYAMIDDGKFYEVQKYVSETGHVFSFEVLIANKAFIDGLPEALRDLVLKAAKDATEAQRKAMAEEEESFKKKVTEAGMTANELTAEEKKPFVAATAEVYPQFADELGQDLMEIIKQVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X7</accession>
    <name>D4M8X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_11470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11470"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.352"/>
    <dbReference type="HOGENOM" id="CLU_1494889_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-728-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04076">
        <property type="entry name" value="TIGR04076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="209" mass="23559" checksum="0DD91BF41A30451E" modified="2010-05-18" version="1">MAGAFSLRVSAEKRGIRAVVSKAIRGVDAMQHRCKVTVIDKRCFPEYQEKYLADPKSGPCPFYHVGDEFIFYRYADEDTFWTMGRGSQCGEAWDCISRYIYTALQGGSIMRHWTNDERMMIACCNDGTRPVVFKIERQDYKVVRLAGAEDAAREVEAKAALEALEGVEGVLVRPDKRWIEVYMPPEGTVDDALLRKAVSAAGLSTERID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y6</accession>
    <name>D4M8Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_11680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.403"/>
    <dbReference type="HOGENOM" id="CLU_075662_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-739-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="227" mass="24923" checksum="B8305A72F8F73ECE" modified="2010-05-18" version="1">MKATKKSEALILFSRLPIGSETKTRLSPLLDEGQREALHRSFWADAFATALELRDRADLFLYWTGSGRPEAYSDLIPAAFALRGQRGLTLGDRMLAAARDAFEAGYERAAIVGTDIPQMRPDSIRRAFDLLAEADVVLGPTPDGGYWLIGLKRAIPELFDISAPWGSGGVRLGTLERARGLGCICAETDSYRDLDTPEDLHAFLEERHPYGAATRSCLERLLGRGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M918</accession>
    <name>D4M918_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Predicted permeases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_12070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12070"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.442"/>
    <dbReference type="HOGENOM" id="CLU_049002_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-771-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="365" mass="39455" checksum="CA1440C24DE7D086" modified="2010-05-18" version="1">MRLFLQYGWQFCQYSWGMLETSGPWLILSFLFCGVLHAVLRPETLQRSLGNKKLSSIVKATISGMLLPICSCGVVPLSLGLYYSGAYLGPTLAFLVATPIINPAAVILAYAMLGPQIATIYLISGFVIPFVIGIVGNALGGPELQSPAAAGLAAAPSAREERPALPPLMQRIRGGIEWGFNDLAVQTCRFIVVGTAFAALLLTVVPTSFILDYLSDPRLVSLLGITLLGCVMYVCALGHIPFIAALVSAGAAPGVAVTFLLSSVATNFPEMVSIWRLIGKRAVTLYTGMLVLFGLAFGYITNFLLADNFRPVFDLTRSQGKIDFVSRISIDFPDGFKVFCAILVLCIGGYGWILQWRRSLRRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D4M976</accession>
    <name>D4M976_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">SY1_13130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13130"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.542"/>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="397" mass="42777" checksum="4C9D6B6DF981646B" modified="2010-05-18" version="1">MKILVINCGSSSLKYQLFDMDHESVLAKGLVERIGIDGSQIKHTKTGLETLVKQTPIPDHKVAIKLVLDTLQGSSHGVLTSLDELSAVGHRIVHGGEDFASSVKIDAKVLEAVKRCVPLAPLHNPANIMGIEAVLEALPNVPQVGVFDTAFHQTMPQHAFMYGVPYGYYEKYKVRRYGFHGTSHYFVSRRAAEMVGQPIEKLKIITCHLGNGSSITAVNGGKSVDTSMGFTPLAGVLMGTRSGDVDPALLPFIAKTEKMGMDEIDMLLNKKSGLLGISGTSSDLRDVEDAALKGDKRAQLAVNMLNYDIKKFVGAYAAAMGGVDVLVFTAGVGENSIPTRAAVCEGLDFLGIKIDPEKNDVRGKEADISAADSRVRVLVIPTNEELMIARDTKRLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M980</accession>
    <name>D4M980_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SOS-response transcriptional repressors (RecA-mediated autopeptidases)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13180"/>
    <dbReference type="HOGENOM" id="CLU_1188554_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-835-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="233" mass="25830" checksum="A9A39321D29AA318" modified="2010-05-18" version="1">MTEGAEAGIGARIMARRKALGMKRPELAERLGVKPNTLYRYEIGSIGIRDSMKSRIAKELGVSLAYLVSGTAEVGRERGSEETPEPVVPPQVYLPILDQEACAGSGFNWSDVRAGARKWMPWPTLETGGPVGPTKPYFVKVEGDSMIGANIQDGCLILVNPNTEVRSGDIAYVRWNDRCSVKGIIFYNDGRVELRPANKDFSSIWIQRDEVEFLTILGKVVRWLNMGVPNRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M988</accession>
    <name>D4M988_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate ferredoxin oxidoreductase, beta subunit</fullName>
            <ecNumber evidence="2">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13300"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.566"/>
    <dbReference type="HOGENOM" id="CLU_048564_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-844-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="52"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="272" mass="29481" checksum="E2BA563042D8F293" modified="2010-05-18" version="1">MPNAEVLSWVRSRFMPHIWCPGCGHGVIMHAIIRALIGIGADRKNTVLASGIGCSSRMAGYINACTLHSTHGRSLAFSTGIKLHRPDLTVVNVMGDGDCTAIGGNHFIHACRRNIDITAIVMNNNIYGMTGGQASPTTPVGAFATTTPYGAVDPTFDICKLAEGAGASYVARTTIANPKQAETFIANGIRKKGFSVIEIVTHCHTQFGRKNNRRLPIENYKYFKENSIPLALAKDKSPEELAGKIVCGEFVNKDTPEYTEQYQKLVIDKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M994</accession>
    <name>D4M994_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized membrane-anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13390"/>
    <dbReference type="HOGENOM" id="CLU_112352_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-850-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025833">
        <property type="entry name" value="GDYXXLXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14345">
        <property type="entry name" value="GDYXXLXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="172" mass="19029" checksum="928059F031DFA6F2" modified="2010-05-18" version="1">MRSSLRYLAAALLPLCVLLWLPLEPICVLTWGREICLAARPIDPRDPFRGDYVALEMDAASVPDAAFRPAFELSAFGRECFVTLAPEPSGLWGPSLVTLTEPEDGVYLRGRIDFRKARSTMHVDLGEGLRRFYVPEGTGQALERAARDGKNYRATVRVLRGRAVIAALDVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A0</accession>
    <name>D4M9A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13510"/>
    <dbReference type="HOGENOM" id="CLU_2316194_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-856-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="99" mass="11316" checksum="FE0F4C3CB32B1766" modified="2010-05-18" version="1">MIESFIEGRVRLRSPLLHDEELARRLSEGLLAIGGVRRAQVNRRTQGLLLEYDKDRLPLERLAPALPIFDRINALERRPADERRAALDAALTDLRHLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B0</accession>
    <name>D4M9B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13660"/>
    <dbReference type="HOGENOM" id="CLU_209079_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-866-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="61" mass="7172" checksum="3005D42CC9E251AC" modified="2010-05-18" version="1">MEDFLRLANEVIHQFYFIMAGGVALLLLRGLFARKTRRSIVYDIVYAYTLIPFLLRALHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B6</accession>
    <name>D4M9B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13750"/>
    <dbReference type="HOGENOM" id="CLU_1041121_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-872-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="267" mass="30369" checksum="779318DA65746DA1" modified="2010-05-18" version="1">MERCDGNLLLLGDDEEKERTYERLIRTWNGREGALVVFDSRGWGEKYGDGHLAASGAGNVPDYLQPVLQHPELGATPAAAAEYLAPICTPKSFRLNVGNDEFWENMAFQTNAQYLEYQVALLKQEDDGHALRTAAKRHRLLLDGMEAIALSNKDEIEGQIKKSRRSRPSIEAPIPGYSLRTTSSSPNGSRHPAADRSSPARPRGKALRRRTGRKLKRWRPWGSFSTPLLPSRGRSWEREGHRTDTWRSRHFARLRRSTPPWRRFSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C6</accession>
    <name>D4M9C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="6" type="ORF">SY1_13920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13920"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.629"/>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="88" mass="10528" checksum="2BDCCD56FE6CBC01" modified="2010-05-18" version="1">MIPKEKKQEVISEYRTHESDTGSPEVQVAVLTERIRELTEHLKAHSKDFHSRRGLLKMVGSRRKLLRYLKEKDFNRYKSLIERLGLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D7</accession>
    <name>D4M9D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_14250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14250"/>
    <dbReference type="HOGENOM" id="CLU_579722_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-893-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17202">
        <property type="entry name" value="sCache_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="321"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="471" mass="52726" checksum="8995CAE2B5160ABC" modified="2010-05-18" version="1">MKGHRFKSIGFKLGLMFFLFGAVIIASIFGIMLRIVTQMEEALIADRLNADINYIKDLIGDGDWNVRHGAIYLGDTLVGDGTETLANLRPFLYHERKTGTFSYVFIRKDDGNLSYVAGTPARKGYMQGPYLRVAGSTKDSEGRSIVGTYIDKQVSDVLDATGVYSGEANVAGSMIYCRYEVLRNDDDQVVGCIVVGRSIAELQSQVNSVIRTMAINIVLAILFLGFILFLLINRWTSTIGRVVAYLKVIEMGDIPSKPLTSQTEDEMETLVTGINLMVDALREKEMLRLKSETDQLTGLANRFGLNRRFEEFFEDCYHNRRPLTVGILDIDFFKPYNDNYGHQAGDRCIVALADVLKEIEGKERVFCARFGGDEFLLIGNGLDLPDVQRIAQEIRDAVAAQHMPHAHSKVANVVTVSQGYCWGVPLEYRKLNDFIYVADSALYEVKRGTKNGFRIVHLTEGFQPVDTDNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H0</accession>
    <name>D4M9H0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine kinase</fullName>
            <shortName evidence="5">HK</shortName>
            <shortName evidence="5">HSK</shortName>
            <ecNumber evidence="5">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thrB</name>
        <name evidence="8" type="ORF">SY1_14870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.746"/>
    <dbReference type="HOGENOM" id="CLU_041243_0_2_0"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="233"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="316" mass="33588" checksum="BB640F4C391B517B" modified="2010-05-18" version="1">MRRDAEPVVALKVPATTANMGPGFDTFGMALSLHNRFSVTDVLPEGRFTVRVTGEGAQELGDVEKNLLVKSYCRACDEWGVPRRGFALESHNAIPLRRGLGSSSTAVVAGVMLANLLTDARAPEDEALRLMTAIEGHPDNVVPCAVGGMTISCWDGERLCCVRLPPLPQDLQAVAVVPDCEVSTESARAILPGEVPFRDAILNVSRAALLAAAWATGRWDVLPFVSEDRLHQPYRTGLIPGGAEVLEEARRRSECAAAFISGSGPTMIALTRGPTEPVASAMRAAFARHGLSARALILSGTAEGATVHDRRTTASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H5</accession>
    <name>D4M9H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14940"/>
    <dbReference type="HOGENOM" id="CLU_213017_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-931-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="41" mass="4562" checksum="EDD74BC2B986C6B9" modified="2010-05-18" version="1">MSPEVVQNFIVSLKIMGQGMEGIFVVIVLISLVVWAMGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9J8</accession>
    <name>D4M9J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_15310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15310"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.789"/>
    <dbReference type="HOGENOM" id="CLU_024867_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-955-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="466" mass="49573" checksum="DFE96441888BFDCB" modified="2010-05-18" version="1">MDAIMKVNDVVNRFVWGAPVLILLVGTGIYLTVLLGLPQIRYFVAAMKEVFTSARGANEADKSISSFAAMATAMAATVGTGNIAGVSTALHLGGPGALVWMLISAFFGMCTKFAEVTLAVHFRQKDAHGDWRGGTMYILEHGAGQKWLAVIFAIFAFLASFGIGAATQSNSAAEGLSMGFGVNHLYSGIAIAALVGLVIVGGLKSLSMVTTYLVPIMAVFYIITSIVVLVMNAAHIPEAIATVFKLAFENPGETVPGALAGWCVKEAVQKGIARGVFSNEAGMGSAPMVHATANVEHPVQQGFYGIFEVFVDTIVICTMTSLVIMTTGTLTGHPELTGSQLTLQAFENALGMGVGRYVLSVALLLFAFTTILGWYWYAETAVTYLFGVWFKPVMKVLWIAMILLGASGAQLFGSAGNVFLNQIWDISDTLNGLMALPNLVGLLILSLTLRRVVKDYDAKKKRGEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K3</accession>
    <name>D4M9K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15380"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.797"/>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-960-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="307" mass="35342" checksum="1E364A8A4D581DC3" modified="2010-05-18" version="1">MKDNASAKEKHGLNRLNDRLFKYIFASRQHKANLIRFLNDVLDDSDRVIADIEYLDREADPPILRGRGTRFDVRAKTSDGRLFQVEVQIRDEDDFLKRCLFYTCANYTSQIVVGEPYGKLGEVVFIAVLDFNAFPDKPDAYHSVQRMLDVENHKCYCNGVEMHFLELPKMRKFGRGKSPDRMTGLERMLMYMGTVGETEALNEIAAYDSDIRRILKMEEAFVKTPELWVNYLIREREQSDWENYVRSREARGEAKGEARGEARGEAKGRAETAQNLIRMGLDLDKIAQATGLPVDEVEALKAEIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K7</accession>
    <name>D4M9K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15420"/>
    <dbReference type="HOGENOM" id="CLU_655143_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-964-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061219" evidence="1">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="419" mass="46219" checksum="C8FBCF141A92C4FB" modified="2010-05-18" version="1">MTRKILLAWFFSALCALALSCAAAFAALAAREADAFIVADAEGTGTSEEQALADARRRAVQQAIGFLSQGLTRTQDGQTEENIVRLSRAFIEKYEVTAKREEKGRHTVSIRAWIRKENLLAGLLQKDPSRSVLDGVSLVTRAATREQQVQEAGDILVDVFRSMPLSNFIRCSTEGTSFQSGSEKLKLGIHFTFDRELFFSQAVPQLVSVLDYVSESSAKDVPFLFPLSGGDPVSITPPVSVDSLPRYRELMDLRDGNFYIDLPDGGGFANIYVLTRNYYFNAYRVAPEAFSRLAESLFRPDRQGMLDGRSLGRTDLKMEFKGGGGAVLFTHTEPLQLHNVLFFMDIAALKKTPWSVRKHGPVDERRHALFVLPAFGTLQGGDYLLIQADEAELELPVPTDVLKAVQKVDSSIVSGSQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L0</accession>
    <name>D4M9L0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_15480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.807"/>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-967-MON"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="253"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="383" mass="41339" checksum="79B8623D57081350" modified="2010-05-18" version="1">MTNLEIAMTRTWAEIDLDALEGNVRSLKGLLKPGVKSLAVVKADAYGHGIVEVARKLETCGVDMLAVAYVMAAVTLRKNGIKLPILCLGQSAPSLAPLMWEYDVTQAVGDLENGLALSRAASAAGRTIKIHVKVDTGMGRIGFYWPESGWEAVADEMATLCRLPGLEAEGLFSHFANADGDPEYTRMQMAKFAAARQALADRGVTFRLGHIAASLGVLRYPEAHLDMGRFGLVLYGYASSDEEVESPAELKPVMTLKARIAAVRELPKGAKIGYGGTAVLKRDSVLAVLPTGYADGYPRALSNRMSVYIHDRLCPVVGRVCMDMFMADVTDVPGVRAGDEAVLLDGRLMLKAALAGHTIIHELLSCIMPRVPRVFIEKGEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M1</accession>
    <name>D4M9M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15750"/>
    <dbReference type="HOGENOM" id="CLU_037957_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-978-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="321" mass="35844" checksum="364EEC0C6C4E3C62" modified="2010-05-18" version="1">MVERYTPTARIEIDGEDRTRPIWEHLESLTYSDAEQGEADSLEISVANDPPFTMPPKGAKVRLWMGYKEESQRLMGTFEVDEASVELKPAVMRIRARSASFSKGKDKQKEDIEWEGITLAELAEKIAARHGYKAKVSMDIRYDAIAQTQESDLHFLQRLAEEANGSFAIRDNTILIFPPNLNSRPKTTLVYTESCTGSFTLADRGKYGSVEAKWWDAAEAEEKSIEVERDEGEAVYTIKKRFRNASEAKVAAENKAELLRRGTIQGSLTVPGDASIVAGAEITLEGFKPDELNGAYLGTNVQQTISKSGWTTRVTLERLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P3</accession>
    <name>D4M9P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16040"/>
    <dbReference type="HOGENOM" id="CLU_2368768_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1000-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="95" mass="10484" checksum="2B260DCD803370C6" modified="2010-05-18" version="1">MKICKTSLLSAAKWLLMVTMLMLTYLPSTKITLALLPILILCSLVIVPAECFHYVIIGCLKHLIWWANLMLGIWVALGGLAFAATLGVRIACRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q7</accession>
    <name>D4M9Q7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="5">SHMT</shortName>
            <shortName evidence="5">Serine methylase</shortName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glyA</name>
        <name evidence="8" type="ORF">SY1_16250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.896"/>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_0"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="7">
        <location>
            <begin position="8"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="418" mass="45640" checksum="1797441E34B9D388" modified="2010-05-18" version="1">MLKHARVSDPEVYKLTLEELTRQEHNIEMIASESTAALEVMELTGSIWTNKTLEGYPGARFQAGSHVADKLETLANQRAMDLYGADHVNLQPYSGSTANYAVYSAVLKPGDRVLGMRLDQGGHLTHGSPANFLSKVYQFDFYGVNQETETIDYEALEKKAKEFQPKLIIEGGSSYPRLIDYERIGAIAKSVGAFSMVDMAHVSGLIAAKVIPSPVPHTDFVSSSTTKTFCGPRSGMVLCKKEFAKQLDRGVFPGALGSMHLHTMAAKAWCFKQMAGAEYKVAMTQVVKNAKKLAEELAKYGFRIVSGGTDNHLILADLRPKGITGKVFQDALDSVGITVNKNQIPFDPEKPTIASGVRIGLTSVTQRGLKEKEIEAIAKIMDKVSSAPEDEANLKACREQAEKLIANFPLYPAGSFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R1</accession>
    <name>D4M9R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_16300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16300"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.901"/>
    <dbReference type="HOGENOM" id="CLU_060714_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1018-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="384" mass="41820" checksum="75DE919C3F1D8946" modified="2010-05-18" version="1">MKGFFAKERGSALTALLLCVGVGLTSWAAARSFMSMWELDALAPAPGFERHRLSEWEPSLSGSPGDTPVFIQQGREPGGTIFIMGGIHANEPAGYMAAVVCLERAQVERGRLIVMPFSNLSALTHNSPQDAAPQRLRFTRDDGTVRSFRCGSRATNPIHQWPNPNTYVHFPSGQELDGTSRANQNRAFPGTLNEGLTQRVGYAITEMLRAERVDLAFDLHEAAPEYPVVNAMVAHENSMELAAVAAMELEMMGLPMRLEPSPKNLHGLSHREWGDSIPTLLPILMEAANPGQGRLRGRTDEALFLTGADKAYVRAAALGRLFVPYDGSQPIQLRVGRHLAAIQAVLSAMEELYPDRAVAVSGIPGFEEVVSHDVGHWLNPLPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R9</accession>
    <name>D4M9R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine/sarcosine/betaine reductase component B subunits</fullName>
            <ecNumber evidence="3">1.21.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_16420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.21.4.2" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.911"/>
    <dbReference type="HOGENOM" id="CLU_050376_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1026-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030699">
        <property type="term" value="F:glycine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016585">
        <property type="entry name" value="Gly/sarc/bet_Rdtase_B_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015417">
        <property type="entry name" value="Gly_reductase_pB_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09338">
        <property type="entry name" value="Gly_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011588">
        <property type="entry name" value="Gly_sarc_betain_red_a/b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Cys)" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR011588-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR011588-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="430" mass="46176" checksum="E0C3EB702CFCEC7A" modified="2010-05-18" version="1">MRLELHKLFVKQLKFGDKTGFSGGTLTVNKKELLDLIAEDPLLGKNLDVDLAMPGESVRIMPVKDVVEPRWKIEGKGQVFPGILGDVETVGEGKTLVLSGAAVVTAGKLVRFQEGIIDMTGPGAEYTPYSETCNVVLVLEPSDPEMDKHDYEKACRVAGIKAAAYLAKACADVKAEKVEIYNQANIKEAMWAHPGLPKVGYLYMLQTQGLLHDTYLYGVDVKKILPTVLSPLEVMDGAIASGNCVSACDKNSTYSHQNNPIIADMLKRHGRDFNFVTCIVTNENVTLADKRRSSTYATKLAAMLGLDGVVISEEGFGNPDADLVMNCWKAERLGIKTTLMTDEYAGQDGASQSLADSCPEGDACVTAGNANEVIVLPPMQKVIGYAEEANVIAGGWQGSLAEDGTITVELQAITGATSELGYTKLGAYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U9</accession>
    <name>D4M9U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein (OmpH-like)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_17100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17100"/>
    <dbReference type="HOGENOM" id="CLU_128691_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1056-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061762" evidence="4">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="156" mass="16855" checksum="7EC111521A190236" modified="2010-05-18" version="1">MILKKSSFLCAAMLLFVLAVGSVSFAAQKPAATVPVEGVGVIDIDEVVNKHPGMANARQQAANLSRQKENEAKAAADKESDQAKKAQIIQQKRMELVKEQQALMDPIYRECQQAARDVAAKQNLTLVLNKSIVLIGGTDITQDVIQQLAKVAATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V4</accession>
    <name>D4M9V4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="12" type="ORF">SY1_17210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17210"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.988"/>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_0"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="161"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="651" mass="74796" checksum="141CF5608D4216A1" modified="2010-05-18" version="1">MKQQNAVRYGVSPLTDYDIFLFKQGTHYSLYNKMGAQRFADKDGTEGVAFSVWAPNAQEVSVVGSFNGWTPGAHPLSPRWDGSGIWEGFIPGLKRWDLYKFHLRNSRGEEKDKMDPFARSFEVPPRTSSVVHWPEYEWGDGDWMRARPKNLSLSAPWSVYEVHLGSWRRHWDNGLSLSYREMAEELPAYCTDMGFTAVEFLPVMEHPFYGSWGYQMLGFFAPTSRYGTPEDFMALVDALHRSGIAVILDWVPSHFPTDDFGLARYDGTALYEHEDPRKGYHPDWGSYIFNYGRNEVRSYLISSAAFWIDQYHADALRIDAVASMLYLDYSRKEGQWTPNVYGGRENLEAISLLQDLNRELYGRFHDVQTIAEESTDWPMVTRPVFLGGLGFGMKWNMGWMHDTLDYMSLESVYRAWHQNQLTFSIWYAFSENFMLPLSHDEVVHGKRSLMNKMSGDWWQKRANLRLLYGYMWTHPGKKLLFMGCELGQGLEWNNDAALEWHLLDKPEFRGIQQWVRDLNGALKQYPPLHERDFSPAGFRWVDCTDWQQSVIAWLRMGERRDEYVLCAANFTPVPREGYRVGVPCGGFWREVLNSDATVYGGSGMGNKGGMEAETIPCHNLPCSLPLTLPPLAIVVFHFTGAPSSEGPQGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V9</accession>
    <name>D4M9V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17270"/>
    <dbReference type="HOGENOM" id="CLU_2769894_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1066-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="69" mass="7691" checksum="AEDFB8C1E7E745C5" modified="2010-05-18" version="1">MMPIPSKITRALSLTPATEMRLEVQKGRIIVTPCERPPEYSLQQLVSMTDFSDRDAAWLDGEAEGAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z2</accession>
    <name>D4M9Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17860"/>
    <dbReference type="HOGENOM" id="CLU_3099136_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1100-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061564" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="51" mass="5198" checksum="C5DD9EBFBBED1371" modified="2010-05-18" version="1">MKGARRANVAGVAALAAAFALSLAGTALAKIDTWKGVGGDTKWSTPDNWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA10</accession>
    <name>D4MA10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_18470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18470"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1108"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1118-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="36247" checksum="9EEFDFCC6F555123" modified="2010-05-18" version="1">MNGNDLLLDVRDLSVQFDTDSGVVHAVNHLNLQLREGHALGFVGETGAGKTTTALAILQLIQSPPGEVTGGEILFKGQDVRKMTDAERRHMRGSQIAMIFQDPMTSLNPIMTVEEQIMEMISLHTDLKGREVRDRAYEMLGLVGIRTERAKDYPHQFSGGMRQRVGIAIALACRPSLLIADEPTTALDVTIQAQVLELIKDLQQKVKTSMLLITHDLGIVAETCDSVAIMYAGRLVEYADLRQLYGNPLHPYTHGLFDAVPDLDTPLGQKLAVVPGLPPDPTNLPAGCSFSPRCSQAQPVCFERACGMVEVEKGHFVDCHFPKKIEGGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA20</accession>
    <name>D4MA20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_18590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18590"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1120"/>
    <dbReference type="HOGENOM" id="CLU_017028_8_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1128-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061565" evidence="1">
        <location>
            <begin position="23"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="68"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="517" mass="56700" checksum="F42C557F1E99A1C3" modified="2010-05-18" version="1">MKKTVFAALSLAMALLCGTALAKDEIVLSGGDNAMAGKIDPVRGYGVWGPDIFHCHLLKPGKDNLLEKDLATDEKVSEDGLRYTYEIREDAKFADGHPLTAEDIVFTFESTKAAASVADLSMLESVRALDDRTVEFTLSRPWSFFPHLLSYVGIVPKHAYKEGYGDMPLGSGAWRIVDFQIGQQMILEPNPHYYGRKSPFKRVTILKVDDDATLAAAKSGQLDFVFIPAEFAATKQEVPGMKLLTLDTFTSLAINLPVIPEGVASGDEKVGNNVTCDPAIRRALNVGISRQLLVDQALSGMGKPSFTIGGGWLPWASKRTFEDGRLEEAKKILEDAGWVDSDGDGIREKDGLKAEFTIKGRSNDMPRYNVVVAVAESAKALGIHIIPQSAPWVEARHARATPTCWAFGYPSPSDFYLFYHSSQINKGVIGNPPSYSNPEVDALIDRALRATSQEESDRLWQQAEELADADVPFLYVACPQDNYLVRDGLTIPPLGRVKSRNQGGAGLENLNEWSWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA37</accession>
    <name>D4MA37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein, Crm2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1150"/>
    <dbReference type="HOGENOM" id="CLU_012640_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1145-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038242">
        <property type="entry name" value="Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024615">
        <property type="entry name" value="CRISPR-assoc_Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013407">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12469">
        <property type="entry name" value="DUF3692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02577">
        <property type="entry name" value="cas_TM1794_Cmr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="326"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="610" mass="67831" checksum="F23A17504A947C2D" modified="2010-05-18" version="1">MSQGTSWLLQISVGPVQEFIAAARRTRDLWFGSFMLSEISKAAAKAVKDARAELIFPEPNGDLKPDSDLNVANVILARASGDDQAMNALAEKAREAAVARFKVFAAEAFEKAKRYIVKERWDKQIEDVIEFYAAWAEIGTGEGAYKAARQKVARLLAARKNLRDFLPHEGEFRVQKSSLDGLRESVFKDGKGPKIAGLCLKEGEVLDSVGLIKRISGDKRKRFPSVSRVAVDPWVRGVKEETLRALEPYCGALVETGAISDVIGYEAFPYEGTAVLLSRHASMLAECELKYEPEEREAVREKVRAACRGIATILSGLKEHDRPQEPYFALLVADGDRMGAAISEIGDMKGHQEFSSTLSKFAGEARDIVRNFHGVCVYTGGDDVLAFLPLDTCLSCARGLHEAFGELLKDYKSIKDQRSPTLSVGISIGHAMEDLEDLLEFGRGAERIAKKGIGDEASRQGVDRNGLAVVVRSRGSDSVIVREQWGRKNTEGLEDTRALAKVSLDERLHYWARLFSDGAIPNKFPYELRENAEFYRGWDPGDVLEAAVRDDIKRIFRRKDVTLSDEEKKRVEGYIDLRLCGHRDIDRLSDELVIAQWIGFGVRQAKGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA74</accession>
    <name>D4MA74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit</fullName>
            <ecNumber evidence="3">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_19370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1202"/>
    <dbReference type="HOGENOM" id="CLU_017038_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1183-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="358" mass="39856" checksum="5DF69A8A8B735CBE" modified="2010-05-18" version="1">MEYALMKGNEAIAEAALRAGCRFYAGYPITPQSEILEYMSDHMEKRGGVFIQGENEVASMSMLYGAAACGARCMSSSSGPGFDLKQEEISYLSAAGIPAVLVNSMRFGLGDGEITAGQDSYWVSTRGGGHGDKRLLVLAPASVQECADLTYLAFDLAEKYRNVVEILSDGAICQMIEKVYLPAEKEHDIDKFDWTLTGKPREQKKNKAYNLSYYMGYEAYNKMMRDKIEAMHRDEQRWDSFQMEDAELLLIAYGISSRVCRSAVRLARKEGIKLGLLRPISVWPYPADAFKKIPTSVRGYVTVEMSITSQMGEDILLASRGDRPLYGYLTSKDLPTAEGIVAHCREIQEGKIQPMEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA99</accession>
    <name>D4MA99_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system core protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SY1_19870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP G family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1247"/>
    <dbReference type="HOGENOM" id="CLU_091705_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1208-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010054">
        <property type="entry name" value="Type2_sec_GspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01710">
        <property type="entry name" value="typeII_sec_gspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="T2SSG" evidence="11">
        <location>
            <begin position="41"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="146" mass="16176" checksum="91B44EB900DA99E7" modified="2010-05-18" version="1">MSKTKYGLHMTRRRGFTLIEIMVVVVILGLLAALVVPRIGPQVAEAQRTMARSQIKSFEEALEMYRMHNGFYPSTQQGLDALVKAPTISPVPKHYVEGGYLKKVPDDPWGNPYIYRNRNGRIQIVSTGPDGEEGGEGEGADVTNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD9</accession>
    <name>D4MAD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_20710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20710"/>
    <dbReference type="HOGENOM" id="CLU_1592150_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1247-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="167" mass="18377" checksum="53183B307AADA1BA" modified="2010-05-18" version="1">MAGNEKIYRPAWKSFYRSISLIVLLAVVVIALTILAPFEAKIKGVLWAAWAVVAIAIFLYMVVRRASISLTVRPDEVALDQGILNRKSIEISYSSIRTVEVTQTLTQRVLNLGDLFIASSGTGEYEMQIKEMPDPHAIRDEIQANERSVKGANAKAGAAQQEDAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF4</accession>
    <name>D4MAF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Molybdenum cofactor biosynthesis enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_20920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20920"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1351"/>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1262-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="295" mass="31960" checksum="816CAD9E6364A646" modified="2010-05-18" version="1">MAHADMMSEDETITAIEAAVGLGVFKLRITGGEPLVKKNILSLCRRAAAIPGVRELCLTTNGTLLPHMAEALKDVGVSRLNISLDTLDPQKYAWITRGGMLSDVLKGLEAAKKSGFTHTKINAVLIGGFNDDELAALADLTRSEDIDVRFIELMPMPAAVCEFGREAFMTAGEAAARLPHLIPLPDEPGELTSHVRLYKLPRARGRVGFITPMSHNFCASCDRIRITADGRVKPCLHSPLEFSIPRPLTAEARGGLDRDEMKRVIMEAVAAKPARHDLQKDRMSAAGRTMNGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF7</accession>
    <name>D4MAF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs</fullName>
            <ecNumber evidence="2">1.17.1.4</ecNumber>
            <ecNumber evidence="2">1.2.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.1.4" evidence="2"/>
    <dbReference type="EC" id="1.2.99.2" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20960"/>
    <dbReference type="HOGENOM" id="CLU_058050_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1265-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="286" mass="30287" checksum="A99ACD5DC3879E43" modified="2010-05-18" version="1">MKVERPRTLLELFSVFKPGTELVAGGTDWVIKRHAKLADDAVVIDVFAVDEMQGISLEGENTEGGFLRIGALETMTSLHRNPLVRRHASALADAAYKMGSEQIRNRATVGGNVANSSPAADTPPALAALGAEAVLASGGGERIVPVEDVLGRNRNTLASCEIIKEFRIPLDVNRVSAFLKIGSRSQVSISRVNLAVLARCTDNLFKDARVFVGTLGLAARRVPGAEEALSAAGFDEAFPAALATFAAEAIPGRPTLPYKQSALRGLAQDICVLLSQRAREAVIGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG0</accession>
    <name>D4MAG0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="7" type="ORF">SY1_21000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1359"/>
    <dbReference type="HOGENOM" id="CLU_006229_0_8_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1268-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="576" mass="63253" checksum="5E966F20B6C5FB74" modified="2010-05-18" version="1">MHALENSRIGHAYLFSGPRGCGKTSIARILAKALNCRAPLGVEPCGSCVNCMAITAGSSPDVVEIDGASNNSVDEVRQLKSQVPLVPFASKYKVYIIDEVHMLSAAAFNALLKTLEEPPSYVVFILATTEPYKVPVTIRSRCQHIPFHSIGARKIFEHLTHVCEWERTAAQPEALWEVARQADGALRDALSMLEQIINRAAGEVTLEDVESALGAGSRPAVERWLSALKGEGSSSYVEFTKMMEGGSPQHVFEELFSLVKNLWLAVRWPNVTRELDVSEQEKKFLAEEAPRWSAEELRTLLEAVANLLVQVRLGVRIDILTGLLMLELSRILEPDGAATRRPQGTASPSPQPLSAGPAAEPVEEPAKGEEERVPIPQPPDERGTDRAEGPLNADWKPASKEAFVKLMAAARQADFVLYCALLDADMKQSGSSVLLDMRDRYPYETLCLERWRSGLLELLEGAADGVFLRYRDEVFACAGGGPRVEEAAGAGRKGAVPQPQEKEETQHPTSPEEEARRPVHPVENASLKDERLSSDLPFDGLVHDLSVLMKGEVVLVRREADEAARERMEEAGEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG6</accession>
    <name>D4MAG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized flavoproteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_21080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1367"/>
    <dbReference type="HOGENOM" id="CLU_017490_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1274-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="35"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="401" mass="44483" checksum="F5C1A2E6E3EFFC0D" modified="2010-05-18" version="1">MYKAIPVNKDTWWVGVNDCSTDRFEALWSLPNGVAYNAYVVLGERTAAIDTVKGPWGDEYAHKLGEALGGRDLDYLVVNHMEPDHSGLILELRRRWPNLQIVGNAKTLPLLKGYYGVDAQTLVVADGDTLDLGGHVLKFTTIPMVHWPESMVTFDASTGVLFSNDAFGGFGAHEGGLFDDQRERPRWEDDMLRYYAAILGRYSSGVQVALKKLGGLPIKNIFPAHGTLFRANPQQVVDLYDRWSRCDTERGAVVVYGSMYGNTRRMAEAVCTGISESGVKEIRLCDASRTEAGFILRDIWRYRGLALLSCTYNMLLFPPIEALCSKLLNRMPKNHVLGIAGSYSWASGAFPALRAFAEKAKLDRAEPDVEVFTSPTAEDLARCEAMGRDLGTKVIAQTEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI4</accession>
    <name>D4MAI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type polysaccharide/polyol phosphate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_21420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1400"/>
    <dbReference type="HOGENOM" id="CLU_000604_101_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1293-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="41"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="442" mass="49551" checksum="D6673B10CB8B61EE" modified="2010-05-18" version="1">MPNTVIKIEELGKKYLLAHRSPQRYIALRDVLVDRAKRLGRRFRHPFARSAREENPAVEDFWALSNLSFEVNEGERVGVIGRNGAGKSTLLKVLSRITEPTTGRVSLRGRVASLLEVGTGFHPELTGRENIYLNGAILGMSKAEIRRNFDAIVDFAGVEKFLDTPVKRYSSGMYVRLAFAVAAHLDTEILMIDEVLAVGDAEFQKKCMGKMDEVSHKQGRTILFVSHNMGAVSQLCNRVVCLERGRVALDTPDVSVGVRKYLNVSKEAGAVAEWRNPGNLFENPWFKPLRFGLYGEDGKAISGPMERKDRVWVEIEGFVEVPDPALEVGYCLYEVNGVLVCYGYQTDQMGGEKELPPLQGNFILRVPLNCSLLNVGNYHVKMEVNLFNRERIVNIHATPPEFSFEISGRLYPSPYRLGESPGILALDQPWVLQPVKSTQIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ6</accession>
    <name>D4MAJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_21690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21690"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1422"/>
    <dbReference type="HOGENOM" id="CLU_417835_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1305-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061868" evidence="1">
        <location>
            <begin position="28"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="656" mass="69512" checksum="7673E12DBFD23224" modified="2010-05-18" version="1">MSNLKKTLFKAALVLCLSLGLASSSWAAQPFEALSARPEKSAYAVLNLQDVGWLVRWALSPENLKVLAPLGGEVDEASINVFADVLKKVPAKGLAVLVGTDDPKAKAGSIQVAVAFPPELQPQLDLVASGKASPDDLSLLLLGSKSEGSPLGGVFSQIEAMDGMVKVNDAVFLGAKDNLLLAAFTPEDLKDALAALGDSGKRLSMKRRFEAGNFAFLHLDPDLADAIGKARASEEGDVTWTEEDSKALRETFRAPLDLEVAFEGFKDRFLVSMGANVEEAMAKDYLANWEGVGPVSGGRILPLGEGSPLIAGGGYLSSQALDSNPRLKALWGSAVEAFKRIGVTEPEARGLMNGDFSLSVGGNISLKGLIGMETKLPGIFMTLTRSNGAAAAFLKKLEASEVAPVNPVKADGWDQMLQADATSSPLPFFMGLKGEALTLGLCDPASFARASAPGAALSELLKKDSMSTFFIDFEGIRAFLADEKNGIAAALSLYDPNLAKRFRDALDVQLSIPSISLWAPTVDTSFLEFRLADVDPAKGLWAKAVELYRSSQGLSPLEQLSMARQVADQAFQEPNADTNAAEALKQRLEDAAVVQQGNKIYVGTLAGDSREELQQAAEGQGLLGSPSLEILPDDKPYAGQEAVWIALDIPQGSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAP8</accession>
    <name>D4MAP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22550"/>
    <dbReference type="HOGENOM" id="CLU_2522736_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1359-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="84" mass="9746" checksum="E7536738FEB72CD1" modified="2010-05-18" version="1">MMKVYIPFSDGSSVAFDGTGFTLQERPRVMDEALSASPASKAAEVWTRDWGAVVRALESAWTRQRDLRRRDRMRQVYSIRRVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ0</accession>
    <name>D4MAQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-terminal peptidase (Prc)</fullName>
            <ecNumber evidence="7">3.4.21.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_22580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.102" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="KEGG" id="sbr:SY1_22580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1501"/>
    <dbReference type="HOGENOM" id="CLU_017295_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1361-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061775" evidence="5">
        <location>
            <begin position="27"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="410" mass="45162" checksum="507AC531A6A689CB" modified="2010-05-18" version="1">MKQKIGRSWVNAAGFLLALLVAGAFAAGHAGAADVSDLDKLSPFSVRSLWLLRQARAIIETYQVDAEEKPTSEEDLLQGAMKGMVEAWKDPYTRYVSPGQLKDEEIEMEGRYGGLGMYIGTRDGQILVISPMEDSPAERVGLKTKDQIVKVDDEVVIGWTSEQVVQRLRGAPDTKVTLWVRREGEDELLKFDVTREIIKLKSVRYQMLSDDVGYLRLTQFKQKTDEEARNALRDILRQGAKGLILDLRNNGGGLLDASVKIVSMFVKGGLVVETRGRAERANEKYFADEALFLTDMPMAVLINGGSASASEIVAGALTDRKRAVLVGEKSFGKGSVQTLFPLTDGSGLYVTIARYYTPSGRVIDHVGLTPEVEVSGDLNRDVMKDAQLQRAAAEVKKRLQPPSGPERQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ6</accession>
    <name>D4MAQ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SY1_22670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22670"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1511"/>
    <dbReference type="HOGENOM" id="CLU_005373_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1367-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="12">
        <location>
            <begin position="178"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="444" mass="49496" checksum="204EF4C5B215F9E5" modified="2010-05-18" version="1">MQLYDRVPPQNLDAERAVLGACLLEHEALGVALETLRPEDFYDLNHRAAYEVMGEMFNASRPVDLVTIGDELARRGVFDKLGGQPFLAALVAEVPTTANIAFHAGIVREKSVRRRLIDAGSKIVSLAYSSELESAMIVDEAERAVFEVSQRNNRADFRPVSDILGRTFQNIEQRYQESGSDVSGFESSFADLDRLTAGFQPGSLNIIAARPSMGKTAFALNIAQFGGGGSRSAVLIFSLEMSAEQLVQRMLAAQSEVDLQAMNTGTMSRGDWDELQNAAGVLTQRPIFIDDSSMLTTMDFRARCRRFKSRYPTLGLVIVDYLQLMSFGGRQTDNRQQEVSEISRMLKGVARELACPVIALSQLSRETEKRPDKKPMLSDLRDSGAIEQDADTVMFLYRRDYYEETQPGVDSEAQLTLAKNRNGPTDTITLVFQREITRFRSWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS5</accession>
    <name>D4MAS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose:LPS heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22940"/>
    <dbReference type="HOGENOM" id="CLU_038371_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1386-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="325" mass="36147" checksum="9D24757193C8D585" modified="2010-05-18" version="1">MSIVRPKDGDRVLWIRFSAFGDVLQCAAGARAFKSAFPGTRLTFLTQKEYGGLLGRQPYIDDLLFWDLKRPWSFFSVIRRIRGRYQWLVSQHRGAAAALTALLSKAPIRLGYNSGLQFAYTTTHWEYLDALGVDFTSRPEPAIFTTESDRAQAQAMLKPLPSRRLFCIIGASKPQKFWPIPHWIDFLRPLVGEGWGVVLNGHGTREMQTAQEIVGALASPLVLNLVGRADFPLMAALAQSCAAAVGNDTGPLHLAALVGTPTLGFFGVTDAWEMGFRMPWFREVRVACPLAGCRNYGCPRDCLADIAPQRALAAFQRMREELSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS6</accession>
    <name>D4MAS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22950"/>
    <dbReference type="HOGENOM" id="CLU_731058_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1387-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="378" mass="42060" checksum="22036AB44FFAD282" modified="2010-05-18" version="1">MRLTVTALCALPALVLLALILKRKSPGQLLYGLVREAEKGLRHVGLCVPSLRLWVMERNPQRICRSPFARLNGAVPDHSPILLNLPTSDGSGEATHPDILHVPQGWGAGGWTWLMAMTPYPLGTDYHENPEFCVSYDGIQWTVPEGLHPPLARVPLKPRNGARAEFHSDPSLLLKEDGELLYYYRWTAVFHSETENRILLTTSRDGVHWTPPEAVLEERRPTGLDRKFLSPSALVLNGKYALWTVDCEGGERFIVRRSGPDGRRWGDPVHAAVSSPFPVNAPWHLDVVDDDGVLRILLTTAAERGYEAELFMGSGDGLSWKVEGKPFTPAYHFEGKRVYRSSLVPLGSGRHRIYYSALSLSGTWNVAMLDAATEKDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS7</accession>
    <name>D4MAS7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_22980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22980"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1543"/>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1388-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="327" mass="35669" checksum="186572A704CA68EE" modified="2010-05-18" version="1">METLRIELDPWNPSGEILARAAEVLRSGGLVAFPTETVYGLGANALNPEAVKGIYRAKGRPSDNPLILHLSRVEQAEPLVCVDERARRLMRAFWPGPLTLVLRARDVVPMEARGGLSTAALRMPSHPVASALIDAVGFPLAAPSANVSGRPSPTDAETVWRDLRGRIEMILDGGPVSVGIESTVIDVSEELPLLLRPGGMPAEEIEAFLGEPLRRPDGRSSRRSPGTRYRHYAPTIPVRVWHPEAPFEMAEMVGMELERWGFMGLAVPPARFGRVLRFESVENYARGLFSGFRALEAEGLLGIVAEWPPAAGVGLGLRDRIRRAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT3</accession>
    <name>D4MAT3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="9" type="ORF">SY1_23060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23060"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1551"/>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="364" mass="40229" checksum="D02E450BBB3B9052" modified="2010-05-18" version="1">MQLGRDFVQALNQIAEERNLAPELIVSSLEAALISAYKKYQSGDQRVEVHVNTETGDILVEELRTVVEELESPDTEITLGDAKRLGFADASVGDELHLEKDPGHFGRIAAQTARQVIIQRLKDAERQVIYSEFSDKVGEMMTGTIVKAENDQVLARIGERTEAILPRKERIPGEEYVPGQTMKFYVLDVRQMTRGPKIVISRTHPGLLRKLMELEIPEVRDGVIEIRNIVREGGGRAKVSLSTMDQNVDPVGACVGAGGARIKAISQELMGEKVDIIVWSSDPLAYIRNALSPAQVVKVEPVLDQEHAAKAYVEPEQLSLAIGKAGQNVRLAARLTGWKIDINALQAERMPTLQDIFHEVAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY4</accession>
    <name>D4MAY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted sugar phosphate isomerase involved in capsule formation</fullName>
            <ecNumber evidence="8">5.3.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_23950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1642"/>
    <dbReference type="HOGENOM" id="CLU_040681_13_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1446-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019146">
        <property type="term" value="F:arabinose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="48"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="285"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL29029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="336" mass="35775" checksum="9E353A1B3DE5EDD1" modified="2010-05-18" version="1">MTSALPCERPGERRSDQELLEAGRRLMRTEAAEILRAADRVGPELTRAAHAVHECSGRVVVVGLGKSGHVGRKISATLASLGTPSFFLHAAEASHGDLGMVRREDVGLFISNSGTSMEIVALLPHFRRLGAMMIAITGGLESPLAQHADIVLNSRVEKEGDPLQLAPMSSTTLQLALGDALAAMVTLLRGLKREDFALFHPGGALGRRLLTRVRDVMGGPGQLPAVPCGVSVQDALFSITSKGYGATCVVDEDGRLCGIFTDGDLRRLIGRRGTDAFLVRIEDAMTKNPKGISPDALAAEAMRVMEREEISVLVALEDGRPVGMLHVHDLLKSGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB05</accession>
    <name>D4MB05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate-formate lyase-activating enzyme</fullName>
            <ecNumber evidence="8">1.97.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_24270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24270"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1667"/>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1467-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL29050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="289" mass="31358" checksum="BAF232B4D15411A6" modified="2010-05-18" version="1">MGTTSRWWKRDEDGRVACGLCFRGCRITDGAAGACGVRLNHGGTLLSPWLGRFCARAVDPIEKKPLAHWRPGSLIYSLGSLGCTMDCPFCQNWRIARPAKSVYGAYASVPFLPPEALAREVRGLGLDALALTYNEPTLQAEYLLEAAPLLREAGIATVLVTNGAMSEEAARDLLPWISAANVDLKAFTPEGYRRLGGDLEAVKRTVALWVRGGVHVELTHLAVPGLNDDMAAFAAMVGWIASLSRDIPLHITRCFPARRHDAPPTSRALLRRMEDAALAELAHVHLGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB06</accession>
    <name>D4MB06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPases with chaperone activity, ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_24290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24290"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1669"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1468-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="426"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL29051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="825" mass="91964" checksum="082C12D583ACD4B5" modified="2010-05-18" version="1">MWQFFTERGKRVIQLAHHEALQMGHPMVEPEHLLVGLAQEGGGIACRALIELDVSPERLCTHIREIMGRSQPASRPIDLPLSPRMKRALELSMVEARKMGVNYVDTEHILLGVLADESSMVVQHFLTMGITREAVLKQVTTIIEASAVSAGGGQGQNVELLTDRLKRQSRSRTPTLDQLGVDLTRKARDGELDPVIGREREIRRVIQALCRRTKSNPVLIGDPGVGKTAIVEGLAQKIASGAAPDPLREKRIIQLNTANLVAGTKYRGEFEERLRRIVKELSDSGEVILFVDEVHTIVGAGSAEGAMDAANILKPSLSRGKFQMIGATTQAEYHKYVERDSALERRFQPILIEEPGIEDSVSILRGLRDRYEEHHQVTFTNDALQAAASLSSRYVQDRFLPDKGIDLIDEAGARTRLRSLDPPESVRELERRLADTQRQKEEAVLNQQFERAAQLRDEEHALADQLEAAMEEWRSGRSEARVEVTGEDIAEVVAEMTGIPVKQLTETETERLLRMEDEISSRLIGQDEAVSAVARAIRRARTGLHDPRRPIGSFLFMGPTGVGKTELARCLARFLFGREDAMIRIDMSEFMEKHEVSKLLGAPPGYVGHESGGKLTEAVRRRPYSVILFDEIEKAHAEVYNVLLQILDDGHLTDGQGRRVDFRNTVIIMTSNVGAKEAQQGSALGFGSAEASEQRNWEHQKAVIMEEAQRTFRPEFLNRIDEMAVFRPLSRDSLLRIVDAMLAELDGRLKGQGLSLDVSVGAKEKILEKGFKPKYGARPLRRAIQSLLEDRLADSLLARKFADGTRIDVDVEDGELRLAPHGAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y1</accession>
    <name>D4M6Y1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">obg</name>
        <name evidence="11" type="ORF">SY1_00230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00230"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1722"/>
    <dbReference type="HOGENOM" id="CLU_011747_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="150"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="343"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL27626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="426" mass="45682" checksum="5A456E655A899A32" modified="2010-05-18" version="1">MVRAGRGGNGALSFRREKFVPKGGPDGADGGTGGSVILEAVGGVVTLADFEYNRRFQAGHAGHGAGAMKTGANGADLKVLVPCGTLVRDESGRVLADLVEPGQTFVAARGGRGGKGNAHFANSVRRTPRFAEKGDPGEERTLTLELKLIADVGLVGFPNAGKSSILAAISGAKPRIAGYPFTTLSPNLGVLAVDDQQIVVADVPGLIEGAHENKGLGLQFLRHIERTRVLLHVVDLSEEDVLKNLEVVEAEFRAYGADLDGRPCIVVGNKTDLSGTEENARVLKREMERLGRPCLLVSALRGDGIPELIREVVALVRAHPRPVGRTTLAEAPEVQDVQELPRRRGGAPEPVEVRRLSDGRFRVDHANLERAVGRINFEHEDAMLKFSRLLKRLSVEEALEAAGAHEGDRVLIGDAEFDFQPERIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z3</accession>
    <name>D4M6Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00470"/>
    <dbReference type="HOGENOM" id="CLU_166037_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-19-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="86" mass="9738" checksum="6F5A407AB06CA49C" modified="2010-05-18" version="1">MSTIRPIECLQDTNAIAALCRQKDEPVFLTKEGDDGLVIMTTQAYARQFCLLDVYRKLAAAEQQLVDGEPLLNADDVFRRLREKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z8</accession>
    <name>D4M6Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase (GNAT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_00570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00570"/>
    <dbReference type="HOGENOM" id="CLU_1084858_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-25-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="119"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="256" mass="27391" checksum="07C9C3EA6F8F7801" modified="2010-05-18" version="1">MNDCFGAVWSNLGAFLDVLRGLSASEAMDLSPEGGFCLSTRSRSASENWVWLQPDLVTQERAEAALRFFGDRGLPFVWPLPGDCEAAETLRAAGLKEAGQLEVMSLPPTPIRGRGGKELTFRTVRTREEALRWASVAWLAFGGEPPVPVSALNGAEAMADSPLRLGAAMAGEEAVGTFLLSPFAASLGVYYFAVLPGYRRRGAAMAMMGEVLRAAKELGTERIVLQATPAGVPFYRAAGFESHGAIPLFSNSDDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M719</accession>
    <name>D4M719_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_00950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.366"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-46-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="277" mass="30299" checksum="ED334BE1A4B603A5" modified="2010-05-18" version="1">MFKYTMIRLRRSYLALFGLFILLVLIVCAVFADQLAPYGYAQQDYMMICKPPSTLHWLGTDEFGRDILSRLIYGSRISLQVGLIAVSISLVVGGLIGAVSGYFGGRLDNVLMRLMDVQMAIPTILMAIVISSVLGPGLFNLMVAVGITYIPKFARLTRASVLSIKDQEFIEAARAMGASHKRIICLYILPNCAAPLIVQSTLSVANAILFAATLSFLGLGIQPPYPEWGGMLSAARPYLRNSAHMSIFPGLAIMFTILSLNFLGDGLRDALDPKQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M732</accession>
    <name>D4M732_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01110"/>
    <dbReference type="HOGENOM" id="CLU_1793667_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-59-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="144" mass="16716" checksum="8665F4D165F199F5" modified="2010-05-18" version="1">MDSMEYKGYINKVFGYSLQYPDIFFDGTFKEDGSEVVMESIHKKYLLKAWGRDLKGKENAKSLLQSLKKDFEKNGNVTIKHSEKLRKNAFSIGYTDPDDRDVLMAQCCVVNGRRAAFFVFKYPHDEHEVFGDILSRMAKSFEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M760</accession>
    <name>D4M760_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytotoxic translational repressor of toxin-antitoxin stability system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01540"/>
    <dbReference type="HOGENOM" id="CLU_155761_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-87-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="84" mass="9493" checksum="8C2DF1D6B5929FA8" modified="2010-05-18" version="1">MMWTVTVMPTAEKQLARIPNPDKGRILAAIVALEDGIEGRDVRPLAGGRDYRLRVGKWRVLMDVDDENLAIYINRVGPRGDVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M765</accession>
    <name>D4M765_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_01610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.733"/>
    <dbReference type="HOGENOM" id="CLU_048533_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-91-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="2">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="443" mass="48562" checksum="9B1D764ABCCC0ADA" modified="2010-05-18" version="1">MQENQSGKGVWKFLVYSLFGLFMFFCPLTLGGKMTIPVDHIINFILQDLLPGAKVYILIVMYVGAALPFIRRTWNKDGLTLFFSFAKVVGAVAGTVIYFNVAPAWLAQKDFGPFLFEKLSLPVGLVIPIGSVFLAFLSSFGLMEFTGVFMTPVMRPLFKTPGRSAIDAVASFVGSYSIALLITNGVYRQDKYSAREAAIVATGFSTVSATFLLIVAKTLGIMDHWTLYFWVAMFVTFAVTAVTARLWPLSWMPETYATGVRSEDPVREGSLMRRAWDAGVEVAENVPPLPQMVWKNFTAGLDMAFSVIPSIMSIGLLGLVLARYTPLFEWMGLMFVPIFELFGVSQASLGGTAAAVSLPEMFLPAILIAKTGTPLLKFVIAVVSISEILFFSASIPCILGTDIPIKLWEIVVIWFERVVLSILITIPIAMLLGFSDVVQAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M785</accession>
    <name>D4M785_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01920"/>
    <dbReference type="HOGENOM" id="CLU_1141265_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-112-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061497" evidence="1">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="243" mass="26878" checksum="C20158C4CE2C0D26" modified="2010-05-18" version="1">MRKTMFSLSLPLLAAAIFLLTQAVPAECLTAEDVKSYVDAAKALNLNGDNLKIGSESAEEILKDDHFMALLRGRLRIARLLKAASDAEGGEGTYALHVEAGPIVAFLCQGGAPTLDRLVQGAVEQVVKPLQLEATLKELPRYYEAIVATADWQKKFGKIMGEGEYPSIQRGKIFHIAGFPEIGDKPYYTAAMDIELKDDTMYLSEWDASAEGWLYSFWMRRWREGTMETAKIAVDLLNKALGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M794</accession>
    <name>D4M794_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="4">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_02050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02050"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1222"/>
    <dbReference type="HOGENOM" id="CLU_037428_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-122-MON"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="550" mass="61660" checksum="60BC5B0C0061A645" modified="2010-05-18" version="1">MATIGAYDEENFKKVNKTQVRPTVEAVFYGNNVHRVLDLKEAYNLAKNSPGTVELTGMPVYHPTEQELPQDANVLLFNDGAIFGRTAAARRIVGWPGVDANALCTVVREAIFNTRHRRMYQADAYVGLDEDFMVKAHLLLPEGYENNLYNWMINFQYDNERYRPRYAASRRISDTDGDIFFFADPDWSHPDFPLGLAFFSPEENCAAVLGLRYFGELKKGTLTLAWGIAARNGYAACHGGLKRYTMKDGRKFVMAAFGLSGSGKSTITHAKHDGRYDIMVLHDDAFIVNIKDKYAIAMEPTYFDKLADYPIGCEDNKYLLTIQNCGATVTGDGRKVAVTEDMRNGNGRSIKSRLWSPNRVDRIDEPLNAIFWLMRDPTIPPVLKLEGPSLGAVLGATLATKRTSAERLAPGVDPNALVCEPYANPFRTYPLSMDYERFKTLLADGVDCYILNTADFMGAKVKKEHTLGIIEAIVEGRARWVPFGDLPGLKTLDMPDFKVDLNDAAYREQLKARFQDRLNFVIARETERGGVDRLPPDAREALEAVIAAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B5</accession>
    <name>D4M7B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antitoxin, RelB/DinJ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02350"/>
    <dbReference type="HOGENOM" id="CLU_154558_12_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-143-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026262">
        <property type="entry name" value="DinJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003108">
        <property type="entry name" value="DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="90" mass="9654" checksum="12D62EA65D640D80" modified="2010-05-18" version="1">MKTDSVIRARIDSDVKHKADAVFARRGVSASTVIRAFFSTVAETGALPIELNVPNEETAAAIRDGRAGLGVRRFDNAASMFATLDEEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D2</accession>
    <name>D4M7D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid/amide ABC transporter substrate-binding protein, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_02600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02600"/>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-162-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003060988" evidence="1">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="384" mass="41914" checksum="788D220586B6E43E" modified="2010-05-18" version="1">MLKKILASLALVLLLAGSGLAADPIRIGYLVALTGDNAPFGITEANMARMIVDEQNEAGGLLGGRPIELIVYDTKTRNEDAVNAARRMIESDRVCVIIGDLASGINIATAPIVNRGHVPQISTIGTNPLVTVDEKGRVRPYSFRICFTDPYQGAIAADLAYNDLKKTKAAILYNVGSDYAHGLREFFTENFKRLGGTIVADEGFRGEDVDYRAQLTTIKASGAEFLFLPGMGKDMALAIKQARELGFDGTIVGGDGFSDIMFEIAGDAMKGTYWINHTYMEDPEMAPIYERYQKRYNDVCKEFLDGAMAADAVYWVFDAITRAGVDEGPAIAKALEETKGLKLHHATITIDPATHDPMNKAGVVLRVDDDLKTEFYKKIEPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E5</accession>
    <name>D4M7E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_02780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1757"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-175-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="333" mass="37598" checksum="1BB25A481A6D66A1" modified="2010-05-18" version="1">MTPILSVRGLEQRFDLDRSFLSQIRFERGRVVRRKRVVHAVNGISFDVPEGRVFSLVGESGCGKSTAARSIIRLLEPKGGTVTYRGQDITHVPERRMLPLRRKLQMIFQDPYASLDPRQSVFDILSEPMLFHGVVAGRREARERVLALLERVGIRPEQASRYPHQFSGGQRQRIGIARALAVNPEFIVADEPVSALDVSIQAQILNLLMDLKEEFRLSYLFIAHNLSVVKHISDEVGVMYLGRIVEKGSRDQIFSNPMHPYTKALFSSIPTLSGHNMNRFAGIQGEIPSAMDLPSGCCFHTRCDYAMPVCSAELPPEREVEPGRFVQCHLFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E7</accession>
    <name>D4M7E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP transporter, 4TM/12TM fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_02810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1760"/>
    <dbReference type="HOGENOM" id="CLU_007041_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-177-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011853">
        <property type="entry name" value="TRAP_DctM-Dct_fused"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02123">
        <property type="entry name" value="TRAP_fused"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="2">
        <location>
            <begin position="118"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="635" mass="66317" checksum="6D0791E3E79C44B9" modified="2010-05-18" version="1">MALFTSEGPEDPPSPLRVPFIDKIRTNAAFALCVAMSLFHLYTAGIDLLQTPVQRAVHVGFVLVLVFLLHPLRRWRWIDALLVLCSIAGTGYIALFSDAIALRGGKVLPYELVLGTLTLIAVLEAGRRVLGRTLPLLGLAFLLYCRYGRYAPSIFMHRGYSLERIVQHLYLTTEGVFGVAVGVSSTFIFLFILFGAFLSGSGGARFFNNLALSLTGRSPGGPAKVAIVASGLLGTINGSSIANVATTGAFTIPLMKKAGYTPEEAGAIEACASTGGQLMPPIMGAGAFVMSEFLNVPYARILSAAIVPALLYYAGLFLNVHLRARRAGLKGLGGDAPGVREVLRDDGHLLLPLLLIVVMLMRAYTPLKAAFWGILVMVGVAGLRRHTRMGPRLVVKALADGARGAVGTGIACAVVGFVVGGSSLTALGPTLSDNILDLAGGALLPTLFLAMGACLLLGMGLPTTANYIVTSTVVVPALVKMGVPPLSAHMFVFYFGIMADISPPVCLASFTAAGIAGANAAGTGIRALLFALTSFLLPYLFIYNPAILMEGGSPLSVLEVSVGAAVGIVAFAAALQGWWGVRLSVPLRIVALAAGALCFVPYTPLRLAGILASLGLGSAARWGGSFFVKESGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7H6</accession>
    <name>D4M7H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1804"/>
    <dbReference type="HOGENOM" id="CLU_323088_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-206-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="397"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="895" mass="98969" checksum="2B8C306341451A6F" modified="2010-05-18" version="1">MDSSISSVKIGTRGEEYAAMHILEVTSIPDVASVLSERQSADESDVIAAYRDGMAVMLSEAHQRWKAWGSGSRDVSVELMWLTRSVANQPYAASIRLFLVSRALAVDRAAAEDAVRSIARDCSTTLDLQRYEYRPLPHGEFATSLSELQTDAIRLLVREGRIRNLQNAILPWCFSFDVIRKSGQDLARIANELASHPGCAFSVQLMPVSYSPQEAAVVDSLSQNLETLQRGVMTQGVGSVGFTLAERPAEVYKYYSENKDRALFRYNIAVLAPERAAEQIMQRLFGQLNAGRDGAVAVKNVSIPVADVGFPWNDHPLPWAINQRLHELTQPADAAVGQGGDLLRVCGQLPGIITAEEAAELFRLPIGSRTVAAGLTVNESGGRKKTYAENVVDGADIEVGQLKSSSGGNTIGFSVDDLTKHALIAGTPGSGKTTFAVGLLDRLWKRYNIPFLVIEPAKNEYRALVRSIPDLQVFTPGKDFISPFIFNPFLPPKNVRLGAYKSTLKTAFAAAVSMSSPLDKIFEEAVNNCYSEFRWLDSYTSANKGRVFNIADFIRCFRETFEAIGYVGEALNIGRAGTVRLGSLSNLFDHYHSIPIEDLLSRPTVIELAAIENNDQKALLIALLLLSILAYVNANYVGEGRLKNVILLEEAHVLLGGGTNAVQGEADPGAIAQELIKRMLAEIRAYGVGMVIADQSPRKVTADVVALTDIKVAFRIVEAGDRQIVSDSTNMDAAQTERLGRLRPGEAFLFFGRLDVPEEVRIPDYRLEQEIGVTLSDEAIRERSTYWRTRQRDLRPYPECGFVRYCAETCRPDLRELAREAAKRIFAKNFKGDTRDFEVLRSVFGSISQRVRAELNDEPFSAELLACTKCHLWRRIRYGTRIDVSDALIRNSLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K0</accession>
    <name>D4M7K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_03690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03690"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1850"/>
    <dbReference type="HOGENOM" id="CLU_371642_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-230-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061502" evidence="9">
        <location>
            <begin position="36"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="756" mass="83803" checksum="8DC72F9CEEAEE4EA" modified="2010-05-18" version="1">MTSGRALRVGSPAGRLLLAVLLALTPLLRPMAAGAAEDWTPPTDVVQAQDEISRDIAQRQAAVEAELGDGKLTSIDIAARMRQLDRLIATASEDAAGWGFSAEQREQYARLLSDLSLDWSAYNSMLQSQPPRATDASGLPASQDLPAVADIDFSDDLLMRIQKAANELDVQMFYLQSKLGVLKLSQSDIESLKGGAGADDGSPTPPKLQELKLELARVRMAASWAQVLAAKRSCDANVALIRSMRAQLASVKGRLTFPEALLNARVASLDREIDETAVQLENGRAMLLSAASDLTKAYAAMKSADVFPLTAASSRYLERKTNTNKLEYSATFLEDKVRCLREAQDLWRKRYKLFHDQVSGQDIWQYRSDARSRMAELERQLEAIQLMKSELQRSIATMTEQAEGTDGRTRQNLGQALQNAKDTVANVLNLYSSLIPNQIFLLQTFYDEASEKLNAVRIAEKVGSFGKATVMDFLNTKLWEGEGYAVTVIKLVTALLVFISSFFLSSWGSRWIQRWILYGLPSQTTAAGAAQRIVFYVLWFAFVLIALQIVNIPLTAFAFLGGAIAVAIGFGAQNLFNNLISGFILIFSRPFKVGDIIEVDGTNGIVEDIGSRSTCIRTWESFDVIVPNRYLLENRVTNWTGSDVKKREVLKVQVAYGTDTRRVEELLTKVIRDHSKALKDPSPFVLFRNFGESSLEFEMYYWVDLTAASTMKVASDMRHHIASLFRQEGIEIPFPRTDVYLVPPIEGSEAQGTLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M0</accession>
    <name>D4M7M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_04040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04040"/>
    <dbReference type="HOGENOM" id="CLU_1945609_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-251-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="129" mass="14333" checksum="8907B144065BE101" modified="2010-05-18" version="1">MSDQPAKKVSAPANKKKLILIGAAVVLVILNVMWTLLQNKFTPRVDALKEEFTKIEARLSKLEKDALPDVEAIRSELNALKLMSEAYENRSSQLLKAEEAQLASLESQLAMQRERVESLKKLGAAEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M6</accession>
    <name>D4M7M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted aminopeptidases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04130"/>
    <dbReference type="HOGENOM" id="CLU_034445_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-257-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="234"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="557" mass="62812" checksum="850E6710C00A3C5A" modified="2010-05-18" version="1">MLNDTERDFLSKLNGTEIERDLREITRYERPSGSEGERLAHEYVASRLEENGMPPLRTTFPAWTFSFGEARMRFWLRGKEGSLPVKIWGYSPDVWEKPVRGRAVFVPPESFPPDSIAWFADRSSWSAGDLEGKIVLSTTRSAIAIQDAFERGAFAYVFCWPYGDEDVIHESAVCAGWGASLPEDVELYPQIPVFAVNRTGGNRLMELAASGDLDIELRGHSRSEVRKLPLLEACLPGDSPYFILLGSHMDAKHHGATDNGTGCALMLALALRFSSLKRRPFGLRFCWWSGHEFSKYAGSSNYALERFGELDKYCLCYINADVPGAKGSEDFSQVAATPDFMALARGAVRDVTGQDGEHFGPVNSYDQSFYNIGVSSCFIWSSQTAPDSPHASGKGGMPWWWHTEEDTFGKHDMEVLMQDCRLYALGTRRILEPGWLPDDRALWDRLIGELEKIDDRQVPDLHSILVSLKTSRERLAGKSGLKERLFVIRKLNQALYCQRAPYFQDFRMGEAYVPGLSLPLEALATQSLTDRAKFVLDRYILAQRNRLLSLAQELERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N7</accession>
    <name>D4M7N7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galK</name>
        <name evidence="15" type="ORF">SY1_04310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04310"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1918"/>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_0"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="123"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="293"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="132"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBL27882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="398" mass="43125" checksum="AF2AAA2614451052" modified="2010-05-18" version="1">MQGIRDMYGRMLSRFQELFGTGGGAPALFRSPGRVNLIGEHTDYNGGHVFPCAISLGIWALAAPRQGTDLVRLHSMNFEEAGTTEAPARGLEYRQERGWANYPLGVLRVLEEAGHPLPAGLDLLFWGDLPGGAGLSSSASIEVLTARVADGLFGMGLQGVETALLAQRAENDFVGMKCGIMDQFAITMGRRNCAVFLDCRTLDFKLVPLNLDGFRIVISNTNKPHALAGSEYNLRRAQCEAALEDLRRVRPVKALGELTEPGFKYLSGVIRNPVNLRRARHAVTENQRTLHALAALEMSDLALFGRLMNQSHVSLRDDYEVSCPELDALVELAWRQPGVVGSRMTGGGFGGCTVSIVEAPCVEAFVRDVGAGYAKATGLRADFYEVDAADGAGRMERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P7</accession>
    <name>D4M7P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FOG: Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04500"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1934"/>
    <dbReference type="HOGENOM" id="CLU_000134_48_9_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-278-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="487" mass="51128" checksum="574C384CB866E1F1" modified="2010-05-18" version="1">MELIQDGANVNAKNDTGTTPLMIAAGNNPNPEVLKGLIEAGADVNAKDKDGWTPLMIATQDSSNPEVLKVLMAAGADLNAKNTGGGTPLIVAAYNNTNPEILRVLLRAGVNVDERQKDGWTPLMAAARYNSNPEVLKILLEAGADLNAKDEDGGTPLMAAARYNSNPEVLKILLEAGADLNAKDEDGWTPLMLAIRYNTTQEVLKILLEAGADVNAKEEDGVTPLMLATSKNTPETLTALLEAGADLNAKNKDEGTPLMAAAQHSSNPEVLKVLIAAGADLNAKNKDGGTALMFAAIHNSNPEVLKVLIAAGADLNAKDEDEWTPLMFAAYYNSNPEVLKVLLEAGTDVNAKNKVGATPLMAAAWHNTNPEVLKVFIEAGADINVKNKVGATPLMAAAGSNPNPEVLKVFIEAGADVNAKNKDGSTPLMAAAGSNPNPEVLKALLEAGADAKAKNNEGQTALDYARMNEKLKDTEALRLLEDKAGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S6</accession>
    <name>D4M7S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RND family efflux transporter, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05030"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1997"/>
    <dbReference type="HOGENOM" id="CLU_018816_14_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-308-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="408" mass="44184" checksum="8763F756885A86C7" modified="2010-05-18" version="1">MHKKISRKFFTFGAVALIAVALAYAFRPLPLEVEMEEVARRPMTLTVDEEGRTRVRDAYTVSTPVNGRLLRVEVRPGDAVAAGKTVVARMVPSVPTPLDARDENRGRADLAAAEAALKLARADRERAVADRDLAQMQLRRMRSLRASGAASQLQLDQAEREARTTAAALHNAEAAIAVREAERKGALSRLRRFGDSETAPQTTAADVIPICAPADGRVLRVMRESEGPLSAGTPLMEVGDVEGGLEVVVELLSSEAVRVTSGDRVVLSGWGGDRPLNGIVEKVEPFAFTKVSALGVEEQRVNVVVRFTDLTESLGRLGHGFRVEARIVVWEDRDALTVPSGALFRNDGKQAVFVVEDGVARLRTVETGRDNGVEAQVLEGLRPGERVILYPASDLTDGARVVEREAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S7</accession>
    <name>D4M7S7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ORF">SY1_05080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2001"/>
    <dbReference type="HOGENOM" id="CLU_097408_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="137" mass="14972" checksum="4BD3117599F873EF" modified="2010-05-18" version="1">MKEFNELIFKDDARYTQTHEWAKKEGNTVRVGVDDFSQSALGDIVYAELPEVGAEVHAGAAFGSLESTKAVSDLNAPVSGKVVKVNEALADSPDLVNKDPFGEGWMIEIEPSNPAEFDKLMAVDAYKEYAKGEHAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T2</accession>
    <name>D4M7T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05140"/>
    <dbReference type="HOGENOM" id="CLU_2972877_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-314-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="58" mass="6812" checksum="8409AD473278D15F" modified="2010-05-18" version="1">MRRRGICVKINAVYLEDNEETLSEVLVFSSAQDITTKIMNDMFGSREYYEKLLAYAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T9</accession>
    <name>D4M7T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05240"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2017"/>
    <dbReference type="HOGENOM" id="CLU_462916_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-320-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="589" mass="66482" checksum="1D6D1339F8F1F90D" modified="2010-05-18" version="1">MICKNLAYWVFTSGEEGVHGLDWGIKHASKSFADQRKLDSRYRLLLKDFSLSPSLEREQEREQEREQERPKKAGLILLPWQGGGKDQDEGTLMGFIFPGSDHKGRPNISTVACVVPADVVHALSLSEVTRALWSSNDLERIARKNSEKPGVSPEGKEGSDEGIAKDDSVRPDTLYLDGEKASSATEVPFPLSSSLKWPKKDVGYLMVDGHVWDLRSLSSPLCPPAEEAAKKRKLRMPQLAALLMALALTFGVACCWGSIRDFSQKYLIQPVYSWWGGGDPSPSTNSPEDPEITERREKRREKREAIIDILSKNKGEDYLKGLAGLMWVPEPWKEKASLVDFLIVEAISENFTVKLKNEKWLVEKGDQGGRGGQEKKLINVSVFKENFKITVLSPLGKDFSSVVDETDRGEFFSISPKKAGIEAWGSLKNDLNDQLSQFIDTTKNPGVSLESATQPIAEDRQALEERLDELLEKSDTQKDKGFGYLSFFYGDGKEGYQVLLLNMEDLSEGKKLDKYIFVKKDNWRRIDVSDLGKRLDGTLQKKPYIKFDDERRDITFFLAPKSKRKKGGDFKEFLDVFFDDLLKSVLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U9</accession>
    <name>D4M7U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2028"/>
    <dbReference type="HOGENOM" id="CLU_055360_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-331-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="234" mass="25053" checksum="90AF77D0925FCC99" modified="2010-05-18" version="1">MGPAAAAEFLRLLAEGAPAASDAEHPRTILLSDPDVPDRSDGIMGLGPDPLPAIKKDLLQLVEWGAEVLAVPCNTAHFFIDRFREELSVPLVHIVEATVNAARRASPEGAWLVATSGTQKSLIYPACAEKAGYLFLRPSREQQECVQQSLRAVKAGDMGRAAELLKEVVEALWREKDLPITTACTELPLAYAAAGLPPDRQISSLQALADACLDLLYERGDGAAGWGVGAFMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y3</accession>
    <name>D4M7Y3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iscS</name>
        <name evidence="10" type="ORF">SY1_05880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05880"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2078"/>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017772">
        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="4"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="201"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="397" mass="42993" checksum="77D14700EAD7C1B6" modified="2010-05-18" version="1">MKSVYMDHAATTPTDPQVLEAMTPYFTEVYGNPSSVYSLSRGSRAAIEKAREQVAAALSADPSEVYFTASGTEADNWALKGTMERMRAQGKDHLITTQIEHHAVLHTAAYLEKVEGLTVTYLPVDPDGRVSASDLKDALTDRTGLVSVMFANNEVGTIQPIGEIGALCRERGIPFHTDAVQAAAQLDIDVRALNIDMLSLSAHKMYGPKGTGAFYLRKGLRLENFMHGGAQEHGRRASTENTAGIVGLGAAILLMKSRLSQDRPRIVSLRDRLIDGVLTKVPHAKLNGARGGLRLPNNANFSFIGVEGETLLLDLDAKGIYASTGSACSSESLDPSHVLLALGLSHEMAHGSLRLTLGRETTDEDIDYVLDVLPKIVARRREMSPLWEDYLKGVGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z4</accession>
    <name>D4M7Z4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-aspartate oxidase</fullName>
            <ecNumber evidence="4">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SY1_06080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2095"/>
    <dbReference type="HOGENOM" id="CLU_014312_8_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-376-MON"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="10">
        <location>
            <begin position="6"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="11">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL27989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="504" mass="54010" checksum="CF12417F0618FA34" modified="2010-05-18" version="1">MSRHSVAIAGSGLAALATAARLHELGVRDIALYANGFGGTPFIAAINFVLPDNPYGDTPELYCTDMLHAGYDIADRETVRRMTSRTADGYELLCRWGVTFARNEDGTLKRRHVSGHTHPRSLCQTTRLIGAEILEAMLTRLEAAGIEVHRRCPVAGLLTRGGRIEGFTVLQDGEPHNVYAPATVAAWGGVGGLLGPTTYPGDVQGNTLGMAKEAGATMIDMEFLEFEPMVMMDPPGTVGEPAPTAMLGEGGHLLNSRGERFLLSVRPQGEGGAPKSLINREAWKQVQSGKGSPRGGVFLDLRHIDRAVLQSYPWFYDRLMKNGCDPNRQLLEVGPMAHSFSGGIRVDADYRSDVQGLYAVGEACGGLHGACRCAGNAASQAVLSGLLCAEGIAKEGGLDRAISPHPLRCTQDATLRGKVLPKLRGIAAHALGIYRNGPDLEAARSAVKAILDEPVTARDDLTRQSALAILTIAEAALNRKESRGTHSRLDFPETDPAFQREFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z9</accession>
    <name>D4M7Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_06160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06160"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2102"/>
    <dbReference type="HOGENOM" id="CLU_019824_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-381-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="11"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="429" mass="45772" checksum="9460289880952594" modified="2010-05-18" version="1">MTISMFFLALCFAVTLAIGVPVVWSLALSSMVACLSIPGISLSFLAQKMELGSEKYALLAIFFFLLAGSIMQHGGIAKRLIAFAKSITSFIRGGMSIVAIITCMFFAALSGSSVATTAAIGTIFYPELVKDGYKKGYAATLPVVGGTLGIVIPPSIVFVVYGTTTNTSVARLLMSGVLPGLLGGLAMCLYAYFYALRHKMPKGAPFRFNAFLDATKDAMWALMMPIIVLGGIYAGIFTPTESAAIACIYGLFVSCGVYRELKLKRLIQIAIESVKSTANVMLIIMAATLFSYVLTRNNIPVMLSNAITSAITTKTEFLLALNILLLILGMVMDAGPIILIIAPIVYPIALKFGIDPVHLGCIIVFNLSVGQATPPFGLCLFAAQPVTGQSIATLSRNAMPFVIILYLMVLATSFIPEIALTIPRLMMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>D4M840</accession>
    <name>D4M840_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acpP</name>
        <name evidence="11" type="ORF">SY1_06740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06740"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2167"/>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_0"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="83" mass="9326" checksum="2ABE41E4DA31D9A5" modified="2010-05-18" version="1">MKKEEVLARLKEIITDRLDVEEDQIVPEATFVEDLGADSLDIVELIMGIEEEFDIEIPDEDAEKLTSVGEAMNYTLGKIGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M851</accession>
    <name>D4M851_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06870"/>
    <dbReference type="HOGENOM" id="CLU_2342694_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-434-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="97" mass="10461" checksum="37388D404BB3DD9B" modified="2010-05-18" version="1">MLELHVSGEAVKMAFPLHSSLEGYSSSRGVFAPPSSTVIPWRLSGFRSRAVCLNLNRMSPLRWLSDSKAASSLLLSVRTGMSTDLGQVAGSRVLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M868</accession>
    <name>D4M868_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07220"/>
    <dbReference type="HOGENOM" id="CLU_1330329_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-451-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="206" mass="22812" checksum="B3147BB2216F5070" modified="2010-05-18" version="1">MQSTWREAIAYAWGNFTGVMSEGSARALRLLLFLIFIGGTAWAVYSYLELQQLREEKTFTASSTTTSVNEDRIRLEAMVTEVRDASARRSGSAMTAQTMKDMGKYLFDDPSRRMAAVVPEIPLPGGGVVAPQVEEVVEPPPEITLRAIMVIDKTKTALIDIAGVGTGLLVKQGDTFLNREGRIVRITNDKVVVRWKKKTWNVTPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C9</accession>
    <name>D4M8C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase</fullName>
            <ecNumber evidence="1">2.6.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_08100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.42" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08100"/>
    <dbReference type="HOGENOM" id="CLU_020844_4_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-518-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="273" mass="30212" checksum="2BFEC0B7DA14DF44" modified="2010-05-18" version="1">MKLCYVNGRFTPPEEAALPLSDLLVQRGVGVFEVIGTYGGRPLLLTPHLERLLNGAERERIRPTLSMEDMKRLVREGLARAGGDVQVKVYLSGGDVFDDVEGFTAPRFFMIFEELSPPPRKAYEEGVALAPLPFGRKDPAVKSVDYRTTYALSRSGAFEVLYCPDGEITEAGHSTFFLVLEGRLVTAPLSRVLKGTTRSVILELARAEGIETQERCPRVDELPRASEAFITGSVKKVLPVVRVGEQRIGTGRPGPVAARLLKLYLDRIQNWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D8</accession>
    <name>D4M8D8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_08320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08320"/>
    <dbReference type="HOGENOM" id="CLU_099018_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-527-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35091">
        <property type="entry name" value="PTHR35091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="151" mass="16049" checksum="54035CE4E86BE31B" modified="2010-05-18" version="1">MKRMIVFVVIGLVMFGVGFGGGLMLGRTMASGEGGAAKAREVAEPGPIVTIGEFTSNLAGAGRHVVSFTVSLELVNKKEEIAAAVQNMGWLVRIKNEILLIAKDKTYDDLNSAEGTVQFQGDIKRVLNSILPNVGGEAPIAQVLFESFVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G0</accession>
    <name>D4M8G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="10" type="ORF">SY1_08650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08650"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.61"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_0"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="SSF57774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="218" mass="23682" checksum="6425032F88690851" modified="2010-05-18" version="1">MRLVLLGAPGAGKGTQAALLKEREACVHVSTGDILRKNLGERTPLGLEAKKFMDQGVLVPDDLVLKMVSSRLLEPDAAEGFLLDGFPRTVPQAEFLESFLTEHHAKLDAVLLFSIADEALVRRLSNRRTCRSCGGIFNLLTMGGAAGAKCPSCGGELHQRDDDQEAVIRNRLKVFHEQTEPLIAWYRDRGLLSEIDAASAPETIYAGVKAALNRHAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G2</accession>
    <name>D4M8G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LSU ribosomal protein L30P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_08680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.64"/>
    <dbReference type="HOGENOM" id="CLU_131047_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-555-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="5">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="60" mass="6999" checksum="D2BB8E0714FF4A4F" modified="2010-05-18" version="1">MAKIKVKWVKSAIGFAERQKRTIKALGFKKLQSTVEHEDTPQIRGMIEHVRHLVVWTVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H1</accession>
    <name>D4M8H1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="9" type="ORF">SY1_08790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08790"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.76"/>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="141" mass="15781" checksum="E9A38BEC8EEA2AEB" modified="2010-05-18" version="1">MLMPSRVKYRKSHRSPLRGVSKGGTTVAFGDWGIQALENVWLTARQIEATRVAISRKMKKGGKIWIRVFPDRPYTKKPLETRMGKGKGAPEFWVAAVKRGRVLFEFSGISPELAAEAFRTASHKLPVKVRIVSREGMGGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8H2</accession>
    <name>D4M8H2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 9">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplV</name>
        <name evidence="10" type="ORF">SY1_08810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6 9">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.78"/>
    <dbReference type="HOGENOM" id="CLU_083987_3_3_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="114" mass="12781" checksum="B601C79016323930" modified="2010-05-18" version="1">MEAKTMARAMARQARIAPTKVRQVLTLIRGKGAEEALTILRFSPQKAARIVYKVLQSAVANAEHNYGMDMDKLYVLTAFADQGPVMKRFRPVSMGRAHPYVHRTSHVTVTVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I2</accession>
    <name>D4M8I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding ferritin-like protein (Oxidative damage protectant)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_08960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08960"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.95"/>
    <dbReference type="HOGENOM" id="CLU_098183_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-575-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="143" mass="16287" checksum="7E7460BC71EB5863" modified="2010-05-18" version="1">MEAKMNALLSDLVFFYHKLQSYHWYISGPTFFQTHAKLEEYYDDIRPQIDEVAETMLMVGYRPVSTMAAFARHAKVKDASEGFVGDVKAVYASILGDFKHLLESVKAIKKDADASDNHLVSTKMDDFIESYSKAIWMISQASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I4</accession>
    <name>D4M8I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type oligopeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_08980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08980"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.97"/>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-577-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061191" evidence="3">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="68"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="533" mass="60182" checksum="B598A963BB837997" modified="2010-05-18" version="1">MKGKKWLLALVAVLCLMGTAWAGEREIVYNLGIEPRTIDPVLNSAVDGSTVLYNISEGLVRIGLDDAPEPGCAESWEVSEDGLSWTFHLREGLKWSDGKPLTAEDFRCGFQRVFNPENACPFAYVGYFIKNGEECFKGTAKLEELGVTAVDERTLRLDLKHPSPLMLDYLSYHIFFPARADVVEQDPRGWSASGSFPCNGPFMITEWKHNSELTVVKNPHYWDADKVKLDKVRMVMINDVNTALAAFKGGKVDYNTLVPAPMLPQLLESGEAKARNTLGTYFYVFNTARRPFDDARVRRAFALAVDRTAIVEKVTRGGQKPANGFIPYGIPGVDPNDPAADFRAEDKAEYLPPRADVEQAKKLLAEAGYPDGKDFPKVQCKYNSNLGNKAIAEALQAMWRQNLGVEVELYNEEWKVFINTRNKKDFDIARHGYLVDFFDAGSLLEMWQTGVWENSASFSDAEYDALIRDSLEQMDRAKRIEDMHKAEQILMREMPVCPLYFYTTPSMQSARVKGIYHSPRNWVFFRGAEVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J3</accession>
    <name>D4M8J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09170"/>
    <dbReference type="HOGENOM" id="CLU_2716598_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-586-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034422">
        <property type="entry name" value="HydE/PylB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43726">
        <property type="entry name" value="PTHR43726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="72" mass="7849" checksum="B875C4890049DF70" modified="2010-05-18" version="1">MGREMGIRAGANVVMPNLSPASVRKKYAIYDGKLCTGEESAQGLARLARRMAGIGRRLSMDRGDVKREAWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J9</accession>
    <name>D4M8J9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiol peroxidase</fullName>
            <shortName evidence="1">Tpx</shortName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peroxiredoxin tpx</fullName>
            <shortName evidence="1">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpx</name>
        <name evidence="3" type="ORF">SY1_09270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09270"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.129"/>
    <dbReference type="HOGENOM" id="CLU_042529_12_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="171" mass="18764" checksum="F5A4509CFE7EA7B4" modified="2010-05-18" version="1">MQERTGIITMKGKPLTLLGTTPRVGDKAPDFVVLDSGLAEKSLKDYAGKVKVLSVAPSLDTPVCSLQLRWFNEDAAQEPGDVVVLNLTMDLPFAIKRFCAVEGIENAIALSDHRTASFGTAYGVLIKELRLLTRSVFIVDKDDVVRYVQVVPEVTDEPNYEDAVEALKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N4</accession>
    <name>D4M8N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIY-YIG catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09880"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.189"/>
    <dbReference type="HOGENOM" id="CLU_052782_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-628-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025579">
        <property type="entry name" value="DUF4357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14267">
        <property type="entry name" value="DUF4357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="242" mass="27171" checksum="CAD5DD65392FE22C" modified="2010-05-18" version="1">MRKDIQEPGVYFLFCKDDENNKDSVYIGEAENVKERLLQHLRDATTEQEKYYWNTALIFVGRDLNKALIRYLENRLVELALASNRYDILTKNTYKNTVLKESQIAAMEEFLENIKVLINTLGYKVLEPLRQGHSGDGEEEKFLYLKTGKTDAVGAVTAEGFVVLAGAKINAKSSDKSLSKGMAKLRQKHFDAGHVSSDLVTTEDILFSSSSSAAIFVTGYSMSGPAHWKDKNGKTLKEIESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P4</accession>
    <name>D4M8P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10030"/>
    <dbReference type="HOGENOM" id="CLU_155311_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-638-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="76" mass="8919" checksum="26D4A9C9ECBA62CC" modified="2010-05-18" version="1">MAQFVLELPQELRERIETRSGAANQKPEKFMLMAIEQYLEDLEDYEDAVRISEEVRSGRMKTYSLEEVRAHLGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q1</accession>
    <name>D4M8Q1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_10130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 5">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10130"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.216"/>
    <dbReference type="HOGENOM" id="CLU_123272_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-652-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="139" mass="15475" checksum="3BBFB1510EDEC64A" modified="2010-05-18" version="1">MKVFDSMEVAGSALTAHRLWMDTISSNLANINTTRTLSGGPYKRRVPVFAEMLDRTIGGYRDIGGVRVTAITEDRTAPRMTYQPDHPDADKDGYVAYPNVNLVREMTDMLVASRAYEANLSVVTTAREMWNGALEVMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q3</accession>
    <name>D4M8Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein HslVU, ATPase subunit HslU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_10160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10160"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.219"/>
    <dbReference type="HOGENOM" id="CLU_033123_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-654-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="53"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="7">
        <location>
            <begin position="360"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="468" mass="52585" checksum="1B64C2518077E5D9" modified="2010-05-18" version="1">MSGLNSALTPSRIIEYLNRYIVGQDKAKRAVAIALRNRLRRRALPPEMAHEIMPKNILMVGPTGVGKTEIARRLATLSDAPFIKVEATKFTEVGYVGRDVETIIRDLMEFGVAMVRRRMLETMQAPALERAEQRLLDAMLPKKERRFSVPDLMKAFGASQEEAAEEDREEEGQAEENTRTRARLLEMLRAGRLDDREVDVEVTDAVTAIPVMGASGMDSMGVNISEMLSGILPKRSRKRHMKVKEALRILQSEEAEKLIDKETLAREALEIVQEGGIVFLDELDKVVVRGGSTGPDVSREGVQRDLLPIVEGSVVQTRYGPVKTDHILFIAAGAFSGVKPSDLIPELQGRFPIRVELEPLSWENLQQILTEPENSLIRQYTALISTEGTELVFTEEATAEIAKLSSKMNAEMEDIGARRLHTMMEQLLEEISFSVCDRSPERIEITADLVRERLAPLVENRDIRRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Q6</accession>
    <name>D4M8Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10190"/>
    <dbReference type="HOGENOM" id="CLU_3043695_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-657-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="54" mass="5932" checksum="AA52091F27C3BB5A" modified="2010-05-18" version="1">MGCETTKLVYSDERPLWLTSDGSLVPAVRGEDGALKGIALYLKDRSGAMRRLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R3</accession>
    <name>D4M8R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinases, ribokinase family</fullName>
            <ecNumber evidence="2">2.7.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.45" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10410"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.251"/>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-664-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008673">
        <property type="term" value="F:2-dehydro-3-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="342" mass="37709" checksum="A8FC6CBC05D6665A" modified="2010-05-18" version="1">MAKYVTFGEIMLRLTPPGHDVLFQTPRLEATFGGAEANVAVSLANYGEDVAFVTAAPANPIGDAMLRELRGFGVDTRFIRRCGDRLGVYYTETGSNMRPSKVIYDRAHSSVSEVEPGDFDWNIVFDGAKWFHTTGITPAIAEGTAKTALGAMKRAKEKGLTVSCDLNYRKKLWKWGKTPKEVMSEMAQYIDVMIANEEDCQKCLGIELDVDVTSGKLDASKYEALARKIMATYKNVQYLAVSLRESMSADWNNWSVVLASKDRFYVSKKYEIRDIVDRIGGGDSFGSGLIWGLNNLDGLQAALEFAAAASALKHTIYGDFNRVSRDDVLTLMGGDASGRVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R5</accession>
    <name>D4M8R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multimeric flavodoxin WrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10450"/>
    <dbReference type="HOGENOM" id="CLU_050993_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-666-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="224" mass="24949" checksum="BC95F1FBA05DB83A" modified="2010-05-18" version="1">MKALFVNGSPRKNWNTHKMLESAMEGAREAGAEAELVHLYDAAFKGCVSCFACKVKGSRTNGLCAFRDPLTPTLEKARGADVIVIGSPVYLGCPTASARAFLERLMFPLLIYGIKERRVLKKTVPTAMIYTMNCPEGSAERFHYSTLLGANADALERTFGYSEALCAYDTYQFSDYSRYEVTLFNEKDKARQRAEQFPKDLQNARELGKRLVEKVASPAESDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S4</accession>
    <name>D4M8S4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">SY1_10600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10600"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.268"/>
    <dbReference type="HOGENOM" id="CLU_074878_3_0_0"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006273">
        <property type="entry name" value="Orotate_PRibTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01367">
        <property type="entry name" value="pyrE_Therm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="41"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="116"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="194" mass="21241" checksum="08FA803CD01DFFAA" modified="2010-05-18" version="1">MEKTQELAVEVLTRLGALKRGHFRLTSGLHSDCYMQCAVLFEHPKESERLCRALAEGFAGQRIDLVASPAVGGVIMGYEMARALSVRNVFAEREDGRMTFRRGFHVEPGERALVVEDVVTTGGSVREVVELLRGAGAEVVGVGSVVDRSGGRVDFGVPFHALMTMEASAWREEECPLCRKGEPIVKPGSRQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V9</accession>
    <name>D4M8V9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">SY1_11190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11190"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.328"/>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="420" mass="44646" checksum="94165A9DF571A807" modified="2010-05-18" version="1">MNVMRIEGGRPLQGTVRTQGAKNAALPVMAACLLLKGGALTLANVPELYDVSTMMELLTALGVTARREGKEVTLGVADEVSWEAPESLVRKMRASSLVLGPLLARCGRAALPLPGGCSIGSRPIDLHLKGLVQMGAKIEIRNGVVCAQADRLRGRRIYLDFPSVGATENLMMAAALAQGETIIENIAREPEIDNLAAVLRSMGVPIDMEGTGCVRIKGVEEVRSCRERVIPDRIEACTYLLAGVMTGGRVTVEDAIPAHIDSLLAKLEEAGVRFAVNGSAVTVFPADRLQSVSLKTMPFPGFPTDLQPQMAAALSLAEGTSVIEESVFQARFLYAAELNRMGADIRVKGDTAVISGVERLSGANVKATDLRAGAALIIAGLAAQGRTQVEDMVHVWRGYEAIDVKLRSLGAQVELAEDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W1</accession>
    <name>D4M8W1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">SY1_11250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.333"/>
    <dbReference type="HOGENOM" id="CLU_035714_4_0_0"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="141"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="257"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="387" mass="41334" checksum="DE2F235D22F92F8E" modified="2010-05-18" version="1">MTTGGTGRKRVAVIGATGSVGSAILSVCRAHPDEVEVRALAARRPSEKLRMLSREFEATMLCAHDAPRGTEGFLTGPEGLVAIAESPEVDQVLFASSGTAAIPALQAALRAGKEVSLANKESIVVAGPWVIPLVSRPDQLRPLDSEHNAIWQCLHGEGEGRAVRSIRLTASGGPFRTWTAEELKTVTPDMALKHPVWAMGAKITIDSATLMNKGIELIEAMFLFGLEPAQVDALVSPGSFVHGLVEFTDGSVKLLAATPDMRLPAASCIFWPERRFPAPDFAPPLLVPRTISFEAPDPVRFPAMRIARTAMERRGAYPALLVGSDEVAVDRFLKGQIGFTDIAAVVEETLESCPLPAPGSLEEALFALEEGRRRAAAVCDGLSRCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y0</accession>
    <name>D4M8Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_11500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11500"/>
    <dbReference type="HOGENOM" id="CLU_2843512_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-731-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="65" mass="7420" checksum="B2FA8C76CCFD6007" modified="2010-05-18" version="1">MKLSIIVEGRTETAFKEALTAFLRSRISRMPRLDFLPQDGRIPKAEKLKRLVHNLLQGARITSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y4</accession>
    <name>D4M8Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_11580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.394"/>
    <dbReference type="HOGENOM" id="CLU_054456_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-735-MON"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="32"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="287" mass="30894" checksum="BACD8A1D3C521F1D" modified="2010-05-18" version="1">MGRDDKSSYECAFDAALYILQRQRVYCEPLTAVVLGSGLGAVAEAVEDPCTVDVEDIPHWPVPTAPGHAGCVVLGKLEGRPVVVMQGRIHCYEGHSIRRAAFPARVARMMGVRQYVATNASGGISAQMEPGTIAAVEDHINLMGDNPLAGPLDLRWDTQFPDLTHAYSPRLLKLRDRAADEAGVQLQRGVYAAFKGPSYETPAEIRMARMMGADLVGMSTVPEVIVANSMGLETAVLSCVANKAAGLSEKPLTESEVLSVMAESAYPLTAIIRGLMRELNREDNKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z7</accession>
    <name>D4M8Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.416"/>
    <dbReference type="HOGENOM" id="CLU_053697_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-750-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="425" mass="47685" checksum="50FEA9C8B835B93F" modified="2010-05-18" version="1">MADYRAMWEGLGMDVKTHDLLCEALPQAFGDVYLSQENRPEGMDYFNMVVAEIHGIRPMELVEHHKKGGRVVGSFCIHVPDEVVVAAGAIATGLCSGSQFWVPGGEKKLPTATCPLIKASLGARFDRTCPFFRLADLFVGETTCDGKKKAWEILAEDAPMYIMDIPQMKRERDYAHWRDDIRGYIRRLEELTGNGVTEGSLHDAIVLLNGKRRALQRLSDFRKLDAVPISGKDVLLITQIAFYDDPGRFTSMVNKLCDELDQRAREGVSVFPKGAKRILLTGTPLSIPNWKLHHLVESLGGAVVCEEMCTGIRYYERCVDEDGRTLDEMVDRLTERYLGGIHCACFTPNSERVDDILRLAREYRADGVIDVNLKFCNIYDTEGYFVERALKDAGIPVLGVETDYTDQDAEQLKTRIGAFLEMLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M915</accession>
    <name>D4M915_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_12020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12020"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-768-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="259" mass="28825" checksum="8D4C12BB663A16B4" modified="2010-05-18" version="1">MALLTVDHVKKSFADRDGHVRSVIDDLSFEVMKGQFVSLLGPSGCGKTTLLTILAGFQTCTEGTAALEGRPIEGPGVERGYVFQNYALFPWMTVRSNILYSLRIAGESREKQEVRLNELLELAHLKGHEGKYPIQLSGGMQQRVAVVRALAGRPKVLLLDEPLGAIDFQMREIMQNELDLLVRQVAATVVMVTHDVSESVFLSDRVLVMGAGGCRLLADVAIDMPRSRDRSSRRFKDYVGDLTDLLRRAFRESEEPFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M916</accession>
    <name>D4M916_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_12030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12030"/>
    <dbReference type="HOGENOM" id="CLU_046113_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-769-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="57"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="256" mass="28044" checksum="A6A4D6F26B096489" modified="2010-05-18" version="1">MGRRKGFVCMLAGTLVVCLLWYFLARAIDRSLILPDFLVTMKTFFLGWFDKKVMSNLGITLMRVFMGCVYAVAIGLPLGLLMGSSRTALVALSPYVNSIRQVPIMAWVPLSIIWFGLGDGPTIFMIAMSAVFPILINTISGVMNIDPNYKNAARCMGAGTWQVLRDVVVPGALPSFLTGCRLALGGAWMSVICAEFIATSKGFGYIMVEAQVRMNTPLLYALMIMSALVGFAMDKSIVLLEHSLTGWRYKDGAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M955</accession>
    <name>D4M955_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_12710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.504"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-808-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="240" mass="26007" checksum="DDDC57EA3C9E9AE4" modified="2010-05-18" version="1">MDPILKVEGLHVYYGSIHAIKGISFDVREGEIVTLIGANGAGKSTTLNTISGLLHPKSGSVSFLGQGLAHTAPHKVVERGLAQVPEGRRIFLQMTVKENLEMGAYVRMRAGGGSVAEDLEMVYGLFPRLRERRRQVAGTLSGGEQQMLAMGRALMSRPRLLMLDEPSMGLAPLLVEQIFDIIRNLNEHGSTILLVEQNARMALSIASRGYVLETGKIVTTGTGQELLDSPEIKRAYLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M989</accession>
    <name>D4M989_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13320"/>
    <dbReference type="HOGENOM" id="CLU_1545379_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-845-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="173" mass="18795" checksum="0B4E353D569A8431" modified="2010-05-18" version="1">MSRKKRPDLKDYLRTGVIRVFDSAEEEREPGPVEAAKRKEAGEAAQSAAPAQPVKSSVAPEEGIALQAEAPGPKPEVPRGVAPEEVLALLSERDRPMWETMLQAATEIICHPFDAEAARADFAEADPSRFTYYLLPSEGAALSPVRSAGQLTDDTRAVLKWDENGAATLWLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9C5</accession>
    <name>D4M9C5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">SY1_13910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13910"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.628"/>
    <dbReference type="HOGENOM" id="CLU_114306_4_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="75" mass="8577" checksum="1D7B4D55BB830B9D" modified="2010-05-18" version="1">MKKDIHPEYQDCKVTCACGNTFTTRSTMKEIRVGVCSQCHPFYSGKKGRVLSEAGRLEKFQKKYQGIHYGQKTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E9</accession>
    <name>D4M9E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_14560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14560"/>
    <dbReference type="HOGENOM" id="CLU_037850_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-905-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="387" mass="42469" checksum="AB301CF60E3955EB" modified="2010-05-18" version="1">MGYSPSHGLSKGVIVNLKEATQSVKRALREAENITNQRINSAIVAFNSLDVNSVMTEGMVALDGREPRRVEEADLMRAIEAAQSRLELPKNTFSVHTIPVRYELDGRPVDEPLNMTGKRLEIMLQTVSVPMTYTQNVLTCVQEGAGIRVKGLVLKPLAASLGSVVEEEMKMGCISLSIGGGATGLVLYRGGRPFKIMSIPIGGEHITSDLATVLRVSLRDAEDVKKRIFMEDDESLRRDGIDIDMAIQVIGARIEELLMDYVRVALADCSPQLFPGGVVLSGGVAKTPGIVEMLGEVLQMKVRVAHPIYAMPPGREDTSYVSAAGLLRYNTYRNSYSHLFVEPNSEDVRLSVEYLDDPMTDAQKPEPTAENLRSFLGGLARKFKELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F3</accession>
    <name>D4M9F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">SY1_14630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.702"/>
    <dbReference type="HOGENOM" id="CLU_053306_3_2_0"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="284" mass="30290" checksum="62BF7A57317292C6" modified="2010-05-18" version="1">MIDCLKMNGNGNDFLVVDNLSLAMDASALARAARAVCRRRESVGADGLLALEPSERAAFRMRLFNRDGSEGEMCGNGARCAARFAFDRGIVGREMTFETRGGDVHAVVRGNRVALDLAPVSTGSAVLKAHASVEGCDFTYAFLVVGVPHAVIFERERRRSIAEYAVLGRALRSRQDLFPVGANVNFALLSSEDSGTLDVVTYERGVEDVTLSCGTGSAASAIAGRLLGVVGDEVRVVNPGGVNDVSLTWIETDVVQPRLEGGALMIAEVRLLPEAFEADCRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F7</accession>
    <name>D4M9F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">SY1_14670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14670"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.706"/>
    <dbReference type="HOGENOM" id="CLU_006406_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="448"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="572" mass="63647" checksum="A83038DD40EDAAB4" modified="2010-05-18" version="1">MDENFSRLNAVEAALVRALHSAALRTAEACGKELPEALSFELERPRRADQGDRASNVAMQLARAFSMPPRDIAARIAGSLQEGCQDLLDRVEVAGPGFINLFLSHRWFAEAASQVLQQGERYGAVDLGQGRRVQVEFVSANPTGPLHIGHGRGAAVGDAVARILSFTGWNVEREYYLNDAGLQIETLGRSTQARYFEVCGRSELAPLPEDGYKGDYLLDLAERIRKEEGDRFLATPLAESLPWFERYAADHILEGIREDLERFGVLFDSWFSEASLYERDLVSHAMEDLKKRGYAFESNGALWFKSTAFADDKDRVLIRSNGVPTYFASDVAYHHDKFVRRGFDRVIDVWGADHHGYVPRMKAAVEAMGRAPDDFKALLIQLVALKRDGKIVSMSTRAGEFVTLRSVLDEVGVDATRFFFLMRRSDSQLDFDLDLAKKQSSDNPVYYLQYAHARISSLLREWEGRGGDVAALRRDGTPLPDLLFDNREARALAETLATFPVEMAGASADLAPHVVTAYALNLAGAFHSFYNTNRILGESTEVERGRLRLAEAVRIVLATCLGLLGVSAPERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9J4</accession>
    <name>D4M9J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP transporter, 4TM/12TM fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15270"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.785"/>
    <dbReference type="HOGENOM" id="CLU_007041_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-951-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011853">
        <property type="entry name" value="TRAP_DctM-Dct_fused"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02123">
        <property type="entry name" value="TRAP_fused"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="2">
        <location>
            <begin position="147"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="669" mass="70757" checksum="B62B3B0E3360CAB7" modified="2010-05-18" version="1">MDSDRRDSAPQADVGTIQDVEAVMKKYDRESNVRIWEGAPKQAVRLLTAAFSLYCVWVTLYSTAMPEIRLNVFLGLILTIGYLNYPIKKGLSRVNHFPWYDALILLAGIVPLFYFAWNAKSIIEMALRVTNPRNPDYPFYTTMAVLAVLSTMELCRRCVGIPILCVVGGLMAYAFSTVRFGKVLYDLYYSTGDGLRSTPIVVCAQYIVVFILFGAFLERTGISAFFIDLANAVAGASAGGPAKVAVISSALCGMVSGSSVGNTVTTGSVTIPMMKRTGYRSEFAGAVEAAASTGGQIMPPIMGAAAFLMAEYMGIPYAQVALKAILPAALYFAGIYIAVHLEARKLGLKGIPREELPRLLSLLPKVYLLLPLVVLVVMVSLNLKTMQFSATVAIGIAILVGIVNPDDRLTPTKFLDALEAGGKGTITVAVACAMAGLVAGCITSTGLASRLITMVVSISGGHTFIALVLTMVCCIILGMGVPTTANYCIMAATCAPILMSPEIGIPKICAHFFVFYFGIVADITPPVALAAYAGSAIAKAPPMRTAVNATKLAIAAFIVPYIFAFSPSMLFEDLHPLLQIAGAGAFLNHALTFAEVAVICVTALLGIFGVAAALNGYLFRPLNPAFRVLMAAGGLSMMVPGTTSDAVGLAVLSAVCAIQWSRSRGRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K1</accession>
    <name>D4M9K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_15350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15350"/>
    <dbReference type="HOGENOM" id="CLU_042602_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-958-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012430">
        <property type="entry name" value="TMEM43_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13416">
        <property type="entry name" value="PTHR13416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07787">
        <property type="entry name" value="TMEM43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="412" mass="44764" checksum="3713EBFA84EDEC6E" modified="2010-05-18" version="1">MAYTETKNTSWGERLGGAFKGVVVGLVLIFLGSWLLWWNEGRTYKQAGAIGEAMVQTQDVADIGTADPALEGRVVHAMGRADTTDVLTDPAFGVSTTAIALSREVEYYQWEEHSKSETRKKLGGGEETVTTYTYSREWVASPIDSSAFHDPLYSTEQPLSRNDMGPNDTLADFEDEEVYAQNVSFGAYKLPPFLVHRIGGAVAMTLSPESVDLQAIAGAIHVSDLYARRYLETPVSADALVHVAGSTVYIGQNPGTPRIGDVRVTFRRTPPADVSIIAKVMSDTFEEYVSSNGYTFSRLAMGKVSMEKMFEDAKSENNTMAWILRVLGIFIVIVGLRTVLSPLAVLVGVLPILESLVGAGIGLVSLLLGLAWSFVVIAVAWVRFRPLLSGSLLVAAAVFLVLTFVRGRRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K6</accession>
    <name>D4M9K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15410"/>
    <dbReference type="HOGENOM" id="CLU_758104_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-963-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061558" evidence="1">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="365" mass="40239" checksum="0933FB69977477D4" modified="2010-05-18" version="1">MKKTIFSCALTLALAWSAAAAEGLFETVVRASGATKEAAVANALDEAIRKNLGTLLSGAEELAGDRLKERLVQFSRGTATRYEVLESGQDENGVVLIVKVTVDPQAVREAARTIRKGGTSGGLARRSTPLLDAGQDGLHTFFQSLDLARFLDVRIEDRTLDVRKGLLTAGVALSLNEARFERDFSEPLARLMDRVANSAGLASELAEEYKTPSERSAAVFYLLGPNLSFRAWTLPAAFLDAARRGARLNDFGRATLRTHRRAWLHFSLRDASGSELERLPVPLNLSNVLLFSDRRSETGNPWFFAGIEERKDRNQLSLIAAPLFGAASGRGYAFFREHRQPFEFRLPQSQLTRVSDITVSLELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K8</accession>
    <name>D4M9K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_15440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15440"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.803"/>
    <dbReference type="HOGENOM" id="CLU_136103_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-965-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="166" mass="17395" checksum="8F5209AFE2C2F8F7" modified="2010-05-18" version="1">MLPFIFCALSIEAVSKAAQAMIEEVRRQFREITGIMEGTGKPEYENCVAISTHAALTQMILPGCIAIVSPILVGWLLGKEALGGLLGGAIVTGVMMAIFMSNAGGAWDNAKKYIEEGNFGGKGSRNHAAAVVGDTVGDPFKDTAGPSLNILIKLMTVVSLVLAPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L9</accession>
    <name>D4M9L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, class IV</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.843"/>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-976-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="7"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="381" mass="40243" checksum="0F25A65802A1DAE8" modified="2010-05-18" version="1">MKVFTIPTVNVVGRGSVKEIGSMAARFGSKTALVVASTGDVGLAQAQLIADVLKGSGIDAELFCKVTPNPLEETVMEGLALYGERGCGFLVAVGGGSAMDAAKGIGILATNGGRIEDYAGVDKVRTPIPPLIAVATTAGTGSEVTQFAVISDANHNKMTLNDRDMLPTISVNDPEMMLSMPPALTAATGMDALTHAIEAYISTESSPLTDGRAWAATNLIAQNLPRAVQEGTNVEVRERMCYGSFLAGIAFNNAGLGLVHAMAHPLGGHYNLPHGLCNALLLPAVCRFNLTFDTVPRFAALARAFGVAHDWRPDRENAEACLEAIDDVKREAGLKESLRAHGVKREDFPLLADRALLETVGATNPRPFDRADVIALYEEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M0</accession>
    <name>D4M9M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Respiratory-chain NADH dehydrogenase 51 Kd subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_15740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15740"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.844"/>
    <dbReference type="HOGENOM" id="CLU_1501409_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-977-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_51K" evidence="5">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="179" mass="18744" checksum="33D668716A304543" modified="2010-05-18" version="1">MDFLECVKSAGVVGAGGAGFPTHVKLDAKAEYFIVNAAECEPLIETDKYLCRTFPDRIVRAVSATAAQVGASRAVIAIKAEYEAEIAALKEAVRAQGAGVTFCEMPSFYPAGDEQVMVQLVTGRSIPERGLPLNVGAVVDNVGTMLNVADALEGKPVTDKFLSVTGAVVKPVVGNLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M5</accession>
    <name>D4M9M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage contractile tail tube protein, P2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15820"/>
    <dbReference type="HOGENOM" id="CLU_130297_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-982-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006498">
        <property type="entry name" value="Tail_tube"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35861:SF2">
        <property type="entry name" value="PTHR35861:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04985">
        <property type="entry name" value="Phage_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01611">
        <property type="entry name" value="tail_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="170" mass="18795" checksum="D44FC7EBB5DFC903" modified="2010-05-18" version="1">MDIKTPRVLRGFDVFVDGRGYAGKVEELELPKLSIKTEEFRAGGMDVPVELDMGMEKLECSFTLADLQADVMRLFGIGHNQPVSLTFRGSFGLGDGRTVPIAIKAQGMIRELDHGTWKPGEKLQQKVTVALKYYSYSESGDMIHEIDVENMVRIINGVDMLAETRAAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R5</accession>
    <name>D4M9R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_16350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.905"/>
    <dbReference type="HOGENOM" id="CLU_001265_61_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1022-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="385" mass="40466" checksum="2D10D73D5E647811" modified="2010-05-18" version="1">MNKSLLALALGTFEFGITEYVMMSILEPAAAALGVSVPTAGILISAYALGVCAGAPLVVLVARRQPLKRIMLALACLCTAGGLTASLAPSFYVLLAARFISGLPHGAWFGVGSIIAQRTARAGREASAVSAMVAGMTVANMAGVPLCTLAANFVSWRAPFIATVVLGALMILAVRFWIPYQEPLPDRGFRGQFRFLKDAKPWLLLLGIALSNGGVFCWYSYINPLITQTAGFSPHSMTLIAAWAGLGMVMGNLLGGRLSDRFAPTKVIFALQGSILFLLTGIFFLFANRWAALGLTFLGTGVLFALSAPQQLLAIRFSPGGEMLGAACAQVGFNLGNAIGAWAGALPVRELGLSYPYTALMGVPFALAGFLVMLSLHRRATRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V2</accession>
    <name>D4M9V2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_17190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17190"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.986"/>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1059-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="8">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="9">
        <location>
            <begin position="612"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="850" mass="92275" checksum="ECAB32D5199C737B" modified="2010-05-18" version="1">MHDSIGDRIDERIDKGRDRLLIVDGHGLAYRAFYAMERQELSAPDGTPTGVLTGFMNMLFFAEERVKPRAVAVAFDAPGPTFRHEMLPQYKATRKPSPEEFKAQVPLLQELLRLMGYPLLIQSGVEADDVMASLALRATEKGWQAVLLSSDKDLMQVLGPGVLIMRPLKSGVSSAEIYSAADFEAEKGFSPSSVPDYLALLGDKADNVPGVAGIGEKTAGELISRWTTLEAVFDGLSEVRPAVRKKLEASGLEAAQRSRDLIRLRLDVPLDLDRCLSAPADPAAALALTERLALRKVARHIMAGPGPAVPATGPEVRFVPLAELAEACCTQGPSVLAMAPLQDGRVQVAAEDGRAADGSGEEALALLERVRPAELLLYDGKAMAARGLTVPEAGAWDLRTAHYLLHPDVAEKTFPSLIAEGEAPAPALFRLRQGLDAAMTRHQGLRDVMEGIDLPLIPVLLRMERWGVRLDPSRFAALQEELAARIRAIEAQVEDMAGTAVNLNSPKQVADLLFVQLGFAPEGKTKGKTGFSTGAAVLEHLARLPGGEVPALLLEHRELSKMQSGFVVPLQKAAEEGEGVIHTTFEPALTGTGRLSSRDPNLQNIPAFGQWAERIKQGLVPVREGNVFVAADYSQIELRVLAHMSREPRLVEAFRNGRDIHRETASWVFSMAPEFVTPELRRVAKMINFGLLYGMSAFGLAERLDMPRGEASMIVKRYFEALPGVQSFLKDIVKEAHAAGFARTLAGRIRPVDEVTAQGRGGLDRVLVNTPIQGTAADIARKAMVDFDRAFRHDGEVRLFLQVHDSLVCECPAARAEEVGHSLREIMMNAATLSLPLEVQLKTGSSLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W5</accession>
    <name>D4M9W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, effector-binding domain/component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17360"/>
    <dbReference type="HOGENOM" id="CLU_065103_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1073-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="275" mass="31743" checksum="BA7EDD9A91E4849A" modified="2010-05-18" version="1">MSNLLTIGEFSRATMLSVKTLRFYDERGILKPVWVDETTGYRHYSAGQFVEALRIRRLRELDVPLEDIRAFLGARDPDAIAAFLARHRQVLQERLEKGHRDLELLEKLTLEKEAFFLSYKVTVREVAPVRALTHRCIVTMENLSEESHRVFTELWTHLERHGSAYGGECFDIYYGEEFDPNDIDVEYCLSFTNPVPETDRLKVRTVPGGLMACTLHKGPYDQLEGAYTALRHWMEENGYEPVAGSDGARNVYLNSPHEVPPEELRTEVQWPVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W6</accession>
    <name>D4M9W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17370"/>
    <dbReference type="HOGENOM" id="CLU_882117_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1074-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="315" mass="35292" checksum="19451F9DB0DD9D88" modified="2010-05-18" version="1">MEKDRRFIMRWFVAFILTVCASASVVVFPRDAAAEPDRTALIGFTASPQSPSAGQDVMVMARFKPDMRPRQGSVTLTLLGRDGGVVREWSERELNPAFLTPVEGGTGEWLYRASFTAQPGYAELRLAWRPSNGSDQADPERAVLTLSVGGNGTPLGGGGLVSWRVTRDARHDGDEMRTNALFERQPDPDSVRLIIERRGLFSGLYDDRTLYPEREGYEDGRYGGRWSVRFEFTAERGRHRMKLRWRMDGTEYEHIEKFSVDDGALGSNGCDAGVSGLLGLSALAPLALRRRREKRRTMAWSPMISVRGEREASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X0</accession>
    <name>D4M9X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidases related to nicotinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_17490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17490"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1011"/>
    <dbReference type="HOGENOM" id="CLU_1632993_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1078-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="162" mass="17129" checksum="C35BB0198D732F07" modified="2010-05-18" version="1">MHTLVSAQSSFFLMVDLQERLLPAISNGEAVVRSSAKLLTAARELSVPLVVTEQYPRGIGPTVPQLAELIPAGTPNLTKTSFSCCGAAGFDAVVTALGRNTAVIFGIETHICVLATAMDLVGRGVKGRPGRGTPAGAARGRTTSWRWPRSGASAPSWCRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X2</accession>
    <name>D4M9X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17540"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1017"/>
    <dbReference type="HOGENOM" id="CLU_2105404_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1080-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="115" mass="12414" checksum="68C896CCBCE79DC2" modified="2010-05-18" version="1">MPGLRGIDNIKKAMERRERERDESLKLALEAERDEAVGTPQVAEEGARDDIERRIAERLADQRRAAEERAAAWRAGATAGAFSASRFIAAAAPRKPAEPAAPNPAPEGQPPFQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA22</accession>
    <name>D4MA22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_18620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1123"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1130-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="289" mass="31148" checksum="62A4E0770A3CAAAD" modified="2010-05-18" version="1">MGELKDSLLRVCHLSVSFESYDTRLERVDYCAITDLSVSLERGEILAVVGSSGSGKSLLAHAVLGILPDNARVGGEMFYCGAVMTDGMKSRLRGREIAFIPQSVAYLDPLMRVGDQVCGTAGESARERQRAAFRHFNLKRETADSYPFQLSGGMARRVLLSTAFVADPELLIADEPTPGLDLELAIEALKDFRVMADQGKGILLITHDIDLALGVADKVAIFHEGRVVETAAAAAFSGDGAGLKHPYSRALFRALPQNGFSLERCPACGASEATWDVDGETMRCRCSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA54</accession>
    <name>D4MA54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19110"/>
    <dbReference type="HOGENOM" id="CLU_972381_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1162-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="286" mass="32846" checksum="9563326D0BB0CB33" modified="2010-05-18" version="1">MTRQIVGTTPRQVAGNRAVQQNVAFRTGRGFIHDDTEPDEERFEEELDVEVNDASDDEEDEAPDDDLDSDSSYHEGEARPSTLVRPIWLWCGGRIVWAADRFGYHLSQREQFRRKFQNLLDYLRSQMGTDFPETTAPWLLREFFTKQSMNADEPSPVSSGSCTPSDSCRGNEENGKGVSWIDQLGRVGLIVERTLTPLDLFIMGQGKKNPEVLEREWLKMQLKRRGIGRPEWKLLKDWLPDEINAFFKDLNASAGTDFHYAPSTLQRKKLAEWSKWDIWSGGESVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA58</accession>
    <name>D4MA58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19180"/>
    <dbReference type="HOGENOM" id="CLU_212092_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1166-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="60" mass="7040" checksum="57A2ABE1F75B1711" modified="2010-05-18" version="1">MMNDALMILINQVITYGYYAMTLLFACALAWNFKRTRDPQEAVLYAVILIPFVLRFLHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA59</accession>
    <name>D4MA59_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_19200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19200"/>
    <dbReference type="HOGENOM" id="CLU_107131_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1167-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046272">
        <property type="entry name" value="DUF6305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19823">
        <property type="entry name" value="DUF6305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061862" description="DUF6305 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6305" evidence="2">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="186" mass="19343" checksum="4778155E59BA064E" modified="2010-05-18" version="1">MNRKGLFLLVLALCLTAASAFAAELPKVETPIVATTCGQSPGAMMVKMSAMQAKVTPVEASKTLTAEEIAGMDCKTLVVTTGTSMKGMGAAGTDVDKEIARCTALIKAAKEKGILVIGAHIEGMARRTDASDEATIKAIIPLADVILVIQDSDSDGFFTNYAKELGKELIVVKDALGIGAKLAELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA67</accession>
    <name>D4MA67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_19290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32620">
        <property type="entry name" value="M.SbaSGP1ORF19290P"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19290"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1194"/>
    <dbReference type="HOGENOM" id="CLU_018284_5_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1176-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="152"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="500" mass="56940" checksum="AB64246B52A1AA08" modified="2010-05-18" version="1">MVTGELKGRIEGLWEIFWTGGLTNPLDVIEQMTYLMFIHDLDNFDNRRAREAAMLGLPYESVFAQDVRIGDRTVDGSQLKWSVFHDFPAGKMYSTVQEWVFPFIKNLHGDKESAYSKYMGDAIFKVPTPLMLDKIVTAMDGIYEQMAQLNAADTRGDVYEYLLSKIATAGVNGQFRTPRHIIRMMVDMMEPKADEIVCDPACGTSGFLVAVSDYLKENRKQEVFFNSQNKDHYMNHMFHGYDMDRTMLRIGAMNMMAHGVDNPFIEYRDSLSDQNPDREKYTLILANPPFKGSLDADIVSTDLLKVCKTRKTELLFLALFLRMLKVGGRCACIVPDGVLFGSSTAHKAVRKELIEGNRLEAVISMPSGVFRPYAGVSTAILIFTRTGHGGTDKVWFYDMKADGYSLDDKRSETKENDVPDIVARFHALDTEQDRKRTEQSFFVPKEEIVGNDYDLSLNKYRQTEYKAVEYPPTSEIMAKLDELEREIGADMDALRELLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA79</accession>
    <name>D4MA79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline racemase</fullName>
            <ecNumber evidence="3">5.1.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_19420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1206"/>
    <dbReference type="HOGENOM" id="CLU_036729_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1188-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018112">
        <property type="term" value="F:proline racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="PTHR33442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029792-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="356" mass="38818" checksum="9EED47EF3EB99226" modified="2010-05-18" version="1">MSFKRVLNVVETHDGEPMRVVTGGVGHIPGNSVYEMEEYLRLHDDGLRKLLLREPRGYPPLCCNIIVPPKHPDAAAGFIIMEQTEYPMMSGGNVISVATALLETGIIPMKEGMNEFNLEAPAGLIGIKARCENGKAVAVTFKNVPAFAVHTDKEIAVPHIGHGVEKVKVDVAWGGMFYAMADARQFPWIKLVPEMGREITRVSSLILKAVQDQLPVEHPNYPGVGVTISQLYDPENYKSDTVDVKNAVTVASGAVDFDDPSTWIGALDRCPCGTGTCARMAAMYAKGELKLNEKFRHQGLLGVVYTGELVEKAKIGKYDAVVPTITGESWIYGYGNLVLDPTDPFPEGFTIGDIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA95</accession>
    <name>D4MA95_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_19730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1238"/>
    <dbReference type="HOGENOM" id="CLU_046525_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1204-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="236"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="376"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="460" mass="50844" checksum="D99C344DD8664C13" modified="2010-05-18" version="1">MNIVIVGAGEVGRSIAATLSGDGHNVNLVEQDAERAKRAEDELDVRVIRGNGARPQVLWDAGVREEDCAADILVACTDRDEVNMLSCWIAHSAGVRHVIARARGLEFTDSPTWGQKLGIDMMISPERSVAREILELLTVSSATRTAELLNGQAAIYAFRVAEDSPLVGKSLKDIRIDYKDLVAIVVCVERPDGESFVPDGDTVLAAQDLCYVVSYKETVYMLEELFQRKNSRPLRRVFIVGGGKIGCQLIQRIQEAYRHAEIRLLDVNEERCRRLSNELGDRNTLFLHEDGIQREVLQEEGIEEADGYVCVTDSDEVNLVYAAMAKAMGVRKSIAVVRRRLYRDMPKYMPVDAVVDLNEALSSTILRTIRYPGHARALSIIEKIDAEMLEVVLPAKHSRAGIPLSDLGLPKGVLVALLGRGNRVFVPMGSTKLEPGDHLILFASTALMREAVELFSEAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA9</accession>
    <name>D4MAA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SY1_20060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20060"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1269"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1218-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="580" mass="64360" checksum="BE06307CE6DD5133" modified="2010-05-18" version="1">MFKMIRQFTFHHPKQILAPTLWLFLSQSSSILPAILAYRAIYLLGQAFYLPYTLDISLLTKIAIIGLGYVLLQYAVELISYYNTYGRAYHDTADKRIAYIQKLRRQSLGFFSSKESGELISSFAGDFANVEYTMCFWLPYPIGVGFLLLLSFVCMLFFDWHMAVAIFAMLPVCAILMLQITKVKEKHSRSVMEAKTRAATQLNEYLHGMKDLKAYHRTGNGFDALEKAFSDLRRESLQDEAVAGSLSTLCASLVKFVVPVTAAVGLYLLLGGSLTILDFAGFLVIATKLTEPALTLVSSLSALRGMALSGERLDRVMTTPAPSGTDEIDHGDSYAFDRVSFCYTEGNDVIHDVSFETPAGALTALTGPSGSGKSTLLRLMARFWDYQQGQVRFAGKELRSIVPESLLSQVSMVMQNAYLFRGTIRENLCFGDENITEQKIIDACRKARCHDFISALPEGYDTVVGEGGATLSGGERQRISLARAFLKDVSILLLDEPTASLDADNEAMVQKALDEISKERTVIMIAHRLKTVRGAQLILVLENGRITQHGTHDQLVGTDGLYSRLWKLQNQAGNYTFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB1</accession>
    <name>D4MAB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_20100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20100"/>
    <dbReference type="HOGENOM" id="CLU_529718_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1219-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061770" description="DUF4139 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="3">
        <location>
            <begin position="205"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="514" mass="55395" checksum="C84929A15192B59F" modified="2010-05-18" version="1">MKLSLFGVLALALLTTFGWACAAQAADFTVRSLDLYPSGAKFVLEVASQGDFEIELPGAFREDSVRLLNPLDAEDFKVVSRRRADWTPPALAGLKAEVEAQAAAVARLNARKSAFQQTLRLLEAIDPAPEDGTQARDLIAYVREAQTLKLDAEKELAELTTALALETEKLEVLREELEARTPDGAGSFLLVSGHGHGDAVLLLEAFAEAAEWSPRYTMNLTTATGAIETDLFALAEQRTGLDYSGVVTFHTKAQDEGVRAPELAPLRVALKPKEQDGDVRKFRRSMSDAGAIAPYAVAAPSAEAARPAPRRLTMTTTLSDRTVTGQGTLSGAGLPSTFTLGRIDLTGKPLLVLIPEQRGSAWLVASMDNAETSLIPGRADLMVDGAPAGVTSLPEYGVGQMRLPFGYAPLITASKEPLVAKTGSSWFSGVSTNGYRIKVTNGMAEDRTVTVRDRLPIPTDDKVKLEVKRIEPAPAERDPENRLTWELSVKAGETVEIVVDYALSYPSGEELLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC2</accession>
    <name>D4MAC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid/amide ABC transporter substrate-binding protein, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_20350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1298"/>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1230-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061238" evidence="1">
        <location>
            <begin position="25"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="29"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="380" mass="40799" checksum="CC15819E40942781" modified="2010-05-18" version="1">MRKVFTALLLALALALTIAGASMGADDVIRIGVFNCLTGQNAFGGQLELEGTQLAHKLNPEILGRKVELVVVDNKSDKVEAANAVTRLIENDKVNAIIGTYGSSLAMAGGEVAEKAGVPVIGTSCTNPLVTQGKRYYFRACFIDPFQGAGAATYAFKNLDFKRAATLVDVTNDYSVGLGAFFKQAYEKMGGEIVAELKYQSGDQDFTAQLTELISKKPDIVFLPAYFAEGAIVLKQARELGAEFRFIGADAMDNPEIVTLGGDAVEGFLHTTFAYDPSMENMNPVAAQFTAEWNKEHPDKAPNVNCALGYDCYVMLADAIARAGSAEPEKIRDALEGTKDLPTVTGMTTINATHDAEKEMGIVEIRNGKKTFLGLVKPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC4</accession>
    <name>D4MAC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20400"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1302"/>
    <dbReference type="HOGENOM" id="CLU_1719686_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1232-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061866" evidence="1">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="152" mass="16470" checksum="3EED1CF8824D7687" modified="2010-05-18" version="1">MRRMVERFAGGVVLVLAALAVLTLAVPAGAAPEVRAEWAEDALAGVTEYDECTAFEGEPQAKVLLSAERAVRDLKVLGLTFTEISEEGKASFDVEERYGQKELLPGRPLLVRMMFFGSIPNNGISYVDGTGATRRFILDQSGEDGSLLLTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD0</accession>
    <name>D4MAD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FOG: Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1312"/>
    <dbReference type="HOGENOM" id="CLU_000134_18_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1238-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="419" mass="45859" checksum="1B8A194B0605001C" modified="2010-05-18" version="1">MLEILTEHYMASSFKGEARGLILGTAGIDLRFIGIWANEPAETLDEPKLELNRDIALHHALNEIDLEKLDREIGFNGDHSFLDANPDFSRICRATSVSQIRNALKSGVDVNARDNRGKTPLMHVVYNPDFMKVLLEAGADVNAKDENGRTALMHTAYAQKDNPAVVEMLVEAEADIDARDEDNKTALMLAAECNKTGIVKMLLHFGANVKAKDKDGITVLMYAVRQRNFWQGGFDPELIDALLEAGADVNAKDEEGMTVLMHAVSNGSNPDSIDTLLEAGADVNERDGDGMTALMYATWQDSPDPRIIDALLRFGSNVNEKDESRKTALMYAAGDGQMSEVIYTLSRADADVNAQDKEGKTALMYAASDNVPTIVGALLDVGANTGIRNKQGKRAVNYARKNRKLTDSEALKRLENGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD1</accession>
    <name>D4MAD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FOG: TPR repeat, SEL1 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20540"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1313"/>
    <dbReference type="HOGENOM" id="CLU_000288_36_14_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1239-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="488" mass="54759" checksum="9A02FAE218D56C8D" modified="2010-05-18" version="1">MEELTTRELYNLGGQALSEENYSRAFAYFLECAKRGEADAQSILGIMYEDAIGVEQNDHKAAEWYLRAAEQGEATAQCKLGIMYEEGRGVEQGDAKAAEWYLRAAEQGEATAQCKLGIMYEEGRGVEQDNAKAVMWYRKAAIQGNVEGQFRLGVMYTKGWGIEKDYKKAAKWYRKVAEQGVSGVQFIVGAMYEKGEGVEQNYTEAAEWYRKAAEQGNATAQCKLGIMCEEGQGVEQNDAEAATWYRKSADQNVPEAQFNLGIMYEEGRGVEQNDIEATEWYRKAASQGIPAAQFNLGLRYEEGRGIERNNVRAAEWYQRAAEQGLADAQFNLGTMYYDGQGVEQDYSKAVMWYRKAAGQGDAEAQFNLGVMYYGGQGIEQDYAKAAMWYRRAAEQGVAAAQFNLGVMYSENQGLERNYAKAAEWFLRAAEQGYTAAQFNLGLLYEEGEGVEQDHEEAIKWYRKAAEAGDIDAQSKLELINKTKKANKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD4</accession>
    <name>D4MAD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FOG: Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20610"/>
    <dbReference type="HOGENOM" id="CLU_000134_18_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1242-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="229" mass="24839" checksum="1F6510945FF0030A" modified="2010-05-18" version="1">MMSSGEIRCFGSVQQVRDDINRGADVNAKDQDGTTVLMMAVQWCRDLDVIDALLQAGADVNAKDACDMTVLEYAIGWNASYEIIALLVKTGANVNARNEHGRTMLMYAVLCNRKTAILSTLIKAGADIDARDHNGLTVLMYAAIKSMASETINILLDAGSDMNAKGEDGMTALMLAARWNSPGIVETLIDAGANVDLKDHEGKRAIDYAQVNERIKGTDTLKRLENVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD8</accession>
    <name>D4MAD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20700"/>
    <dbReference type="HOGENOM" id="CLU_2953812_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1246-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="59" mass="6570" checksum="C34568F0804A66B9" modified="2010-05-18" version="1">MPISTLVCMVSQEVSARLSSFKCGRCLGIWAARAGTAQNAKNIEGRTRDLIRRFQPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE5</accession>
    <name>D4MAE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit</fullName>
            <ecNumber evidence="13">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SY1_20810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="13"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1340"/>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1253-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="599"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="628" mass="68048" checksum="36D803289D5E60B1" modified="2010-05-18" version="1">MTRIASVRELKERQAAAERGLALQDKKVVVCCGTGCVAGGSLKIYDRLRELCEGAGLSVSVELGLEPGHRDLGMKKSGCIGFCEMGPLLHIQPLDVLYTRVSLEDCQEIFERSLKGNEVVERLLYRAEGGTCRTEDEIPFYRLQTHNVLEFCGKIDAVDLNEYIARGGYAALGKALHDMTPEAVCDEIDRSGLRGRGGAGFPTGKKWKSVLRQKAPKHYVVCNGDEGDPGAFMDCSIMEGAPYRMIEGMTIAAYAARSDEGYIYVRAEYPLAVKRLRTAIERATEAGLLGDGILGTDFSFKLHINQGAGAFVCGEGSALTSSIEGNRGMPRVKPPRTVEQGLFGKPTVLNNVETYANVPKIVQEGADWFRGIGTEGSPGTKAFALTGNVVNTGLIEVPMGTTLRKIIFDIGGGIRNGKKFKAVQIGGPSGGCLCLDEHLDLPLDFDSLQRIGAMIGSGGLVVMDEDTCMVEVARFFMNFTQRESCGKCVPCREGTKRMLEIVERIVGGQGRPEDLDLLEELADTVKNTALCGLGKTAANPVTSTLRYFRDEYEAHVSEKRCPAKVCQKMKRFEIDAAQCRGCTKCARSCPVGAISGVVKAPHLIDDGKCIRCGACMENCPFGAIREAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH5</accession>
    <name>D4MAH5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">SY1_21250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1384"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="608"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="817"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="822"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="527"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="883" mass="101047" checksum="877BF2870E39A39E" modified="2010-05-18" version="1">MKRNRELAKGYSPDAIEEKWYAFWLEKGLFNAEPDASKEAFSIVIPPPNVTGSLHMGHAFNNTFQDILCRTKRMQGYSVLWLPGTDHAGIATQNVVEKDLAKKGLTRHDLGREAFVKKVWEWKEVYGDRIIKQMKRLGNSCDWRRERFTFDEGLSRAVRAVFVRLYKKDLIYKGKYIINWCSRCHTALSDLEVEYREMPGKFYYVRYPFVGEEGSLLVATTRPETILGDVAIAVHPRSEQYRGMIGKRVRVPLTDREIPIIEDNMVDPEFGTGCVKITPAHDPNDFLVGQRHDLEQIQVIDSEGVMNENAGRYRGMTLEQAREAAAKDLDALRLLERTEEIKHSVGHCQRCGTTVEPYLSEQWFVRTKPLAERGVQAVKDGRITWTPEQWEKTYFHWMENIRDWCISRQLWWGHRIPAWTCADCRHVTVAETDPAECEKCGSRNIAQDEDVLDTWFSSALWPFSTMGWPERTPTLDYFYPTSLMVTGFDIIFFWVARMIMMGLEFMDEVPFKDVYIHSLIRDEKGDKMSKSKGNVIDPLVMIDQYGADALRMALAALSTQGRDILLSSDKIETYRHFMNKLWNAARFALMNLDDEPQPIDRARLRLQDRWILTRCQEVTQKITKCIDGYDIGEAARSLYDFTWGDVCDWYIEMSKPALRGDEGPERRRTAQGVLDEVFKTLLPLLHPFIPFVTEELWAAFGWGDTSIMRAPWPRPQEALCFADARTSMRALQDTVSALRNLRAEAHVAPQQWMSRAVIRVDNPAVAEMLRDNLGQLSGLCRVHEVAITPLSEPRPAASLASVVGDAEIGLPVGDVLDIPSEIARLTQEIASIEKNVAASRARLDKPSFVSRAPQEVVEKERARVAEGTAQIARLKENLDSISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH6</accession>
    <name>D4MAH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaconyl-CoA decarboxylase beta subunit</fullName>
            <ecNumber evidence="9">4.1.1.3</ecNumber>
            <ecNumber evidence="9">4.1.1.41</ecNumber>
            <ecNumber evidence="9">4.1.1.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_21260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.1.1.3" evidence="9"/>
    <dbReference type="EC" id="4.1.1.41" evidence="9"/>
    <dbReference type="EC" id="4.1.1.70" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1385"/>
    <dbReference type="HOGENOM" id="CLU_036168_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1285-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="397" mass="41999" checksum="F12A3E82B958853A" modified="2010-05-18" version="1">MEMYVTALRELFDSSGFAVLFSPAGTGNLVMIIVAFVLLYLAIGKGFEPLLLVPIAFSCLLVNLPLSGIMDLPTAENPSLGFLRAVYFGAQYEIYPIIIFLGIGALTDFGPLIANPITFLLGAAAQFGVFVSFIGANWVGPIAKSFGLDVAFNIKQAASIGIIGGADGPTSIYLTMKLGQEEILGAIAVAAYSYMSLVPLIQPPFIRMFTSKKDRGIVMSELRPVSKREKILFPIICTIVAGLVLPACVPLVGTLMFGNLLRECGATERLSQTAQNELLNITTIFLGLAVGSTMEADKFLQARTLIIVLLGLIAFIFSTVGGVLFGQLMKVLSGGKINPMIGSAGVSAVPMAARVVQRVVQEEYPGHFLLMHAMGPNVAGVIGTAVAAGVMLTLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ4</accession>
    <name>D4MAJ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="11" type="ORF">SY1_21670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21670"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1420"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="354"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="397" mass="42112" checksum="1A16ABCC563CB79E" modified="2010-05-18" version="1">MFAMRLKTFDQGDVRGKKVLMRVDFNVPFKDGKVTDDARIRAHAGTLKKLMDAGAKVALVSHFGRPKGQVNPAFSLAQIVPDVEKAYGLKVRFVDDCVGPRVEAAMRDLGEGEVVLLENSRFHPEEEKDDPAFAELMAKPFDVFVMDAFSAAHRANASTAGVIPHLKSFAGDLLVREGEMLGAVSENPAKPYALILGGAKVSDKIAVVGNLLDKATVILIGGGMAYTFLKAEGKEIGRSLCEEDRLDFARETLKKARAMGVKVLLPVDSVVASGLDATETRTVASDAMPADMMGLDIGPRTIAEFSAALRGARSVLWNGPMGVFENALFAEGTRAICQAVADCTASGAVTVIGGGDTASAVRQFGFAERVSHVSTGGGASLEYCEGKKLPGMAPFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAM9</accession>
    <name>D4MAM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage CP4-57 regulatory protein (AlpA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22240"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1474"/>
    <dbReference type="HOGENOM" id="CLU_2355638_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1338-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="96" mass="10870" checksum="8D5F8F90F33D1DB7" modified="2010-05-18" version="1">MEGELTVRLSPKDINAIADRVCEKMLPALRVPEPAASPEDLMTAKEVQAFLKIKPSAFYEWLKNKTIPEGVRIGPKERRWARGDILSLVKKREEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS4</accession>
    <name>D4MAS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein, interacts with FtsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_22910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22910"/>
    <dbReference type="HOGENOM" id="CLU_058671_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1385-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="PTHR23291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="239" mass="26116" checksum="5F1E2F4E562ECEB5" modified="2010-05-18" version="1">MSQEFTRELSYSVADSRVDLVNALFRRVYQWMAIGLILTAVTAYGVASNGTLMRVFYGSPMPLIVVAVATLGLVFALSAGIRRISAGAASALFVIYSVLNGLLCSGVLLIYAQESVYAAFFSTAGMFAVMSVYGLYTRRDLTSLGSFLYMGLFGLIISALVNLFVRSTMVEFVSSIIGVIVFLGLTAYDTQAIRRMGDEIEDGEDGVTIRKVAVLGALSLYLDFINIFLYLLRLFGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAT5</accession>
    <name>D4MAT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_23130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23130"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1558"/>
    <dbReference type="HOGENOM" id="CLU_126458_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1396-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="182" mass="20584" checksum="4BBD7E82D9C66E30" modified="2010-05-18" version="1">MTSIETITIDESGMTFGPYPSERCFHIEKSALYKDIRQGVKMAEFLLLRADSNRPAMLWVVEAKSSSPRPKSEPDFSQFIAEVREKWIDALSLTLASLLGRHRQAGAELPGPFELLDLSQFDVRFVLVINGHPKGWLPPIQDALRQSLRPLVRIWRFAPTSVVVLNEELASKRQLISANRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX5</accession>
    <name>D4MAX5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="10">NN:DBI PRT</shortName>
            <ecNumber evidence="4 10">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobT</name>
        <name evidence="11" type="ORF">SY1_23820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4 10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23820"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1621"/>
    <dbReference type="HOGENOM" id="CLU_002982_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL29020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="362" mass="38303" checksum="6FEF9821A89B2923" modified="2010-05-18" version="1">MQEHLTIEQAVARIAPLDAAAVRAAEERQKGLLKPVGSLGELEALSIRLAGITGKVKNSIDRRVHLLFGSDHGVYDEGVSGSPQYFTRVLMEFYAADVGCGINVLCRRAGVDLRLFDLGVRDLGPTPRVDASCKLMPRGTENFARGRAMTPETARRAVEFGIECAGRAREEGYQILGAGEVGMGNTTPAAACIMAALDSRDSALVGRGGGLTDAAFETKKRVILGALDRHRPDPQDALDILSCVGGLDLAAMTGVFLGSAAYRVPAVVDGVIAIAAALLASRIAPLSREFLIASHRSVEPAYAAVAEAMGLHPLVTLGMRLGEGTGCPIAMQIVDDALTVMNEMGTFAEVSLESEYREVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY0</accession>
    <name>D4MAY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoribonuclease VapD</fullName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_23870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cleaves ssRNA, mostly between U:A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the VapD ribonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23870"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1626"/>
    <dbReference type="HOGENOM" id="CLU_145265_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1442-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016368">
        <property type="entry name" value="VapD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002882">
        <property type="entry name" value="VapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL29025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="96" mass="10875" checksum="4114CD1AEC31B1FA" modified="2010-05-18" version="1">MYAIAFDLEQDTLSKTYGNPSYTNAYNDIKKVLESYGFTRQQGGVYFGDSKVDAVRCVLAVQDLAKKFSWFSASVEDIRMLRIEDNNDLMPAISND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB01</accession>
    <name>D4MB01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+ transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_24170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24170"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1659"/>
    <dbReference type="HOGENOM" id="CLU_026974_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1463-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061873" evidence="2">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="337" mass="36946" checksum="F8B456FCE1FC9E19" modified="2010-05-18" version="1">MRSGKCAFFLACAMLAVVAGGAWAAEAVNAYTTMEEPLAKALFDAFEAESGIKVQWVRLSGGEAVARIEAEKANPQASIWVGGVGTQHIEAKLRGLTAPYRSRVADSIPADYRDPENYWTGLYVGPIAFCMNTERAKELKLDMPKTWMDLLKPEYAKSVRMAHPATSGTAYNMLTTLIRIYDGDEDKAFDYFKKLSASVEQFTRSGSAPGKSCAIGEIPIAIGYLHDQVKLQKEGAPIEIVIPSDGTGAETASMSILKGGPDALNAKKLYDWILGQKAMDVIASWYVIPLSSLATPSETGFSLDKMKMLKDDQWDAANKERLIERWNREIAMAPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y0</accession>
    <name>D4M6Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_00190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00190"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1294"/>
    <dbReference type="HOGENOM" id="CLU_068238_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-6-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="265" mass="28455" checksum="2A1E55AD208F5E82" modified="2010-05-18" version="1">MRVLFLGDVAWSVGRRALACALPELRREWGGFDFVVVNCENAAAGKGMTEKIFKEFLDLGVDGMTSGNHIWDKNDFGVVLGSDARIFRPANYPAVCPGQGCGVLERGGRRLGILNLEGQVFMPPIDSPFYAADACLEELRAQGGPELPILVDFHAEATSEKEAMGFYLDGRVSAVLGTHTHVQTADERILPGGTAYLSDVGMTGGHGGILGVKKESAMPRFLTGMPARFEMCTELPAVNGAVVEIDESTGRARSIVRVQKAVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M702</accession>
    <name>D4M702_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_00680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.102"/>
    <dbReference type="HOGENOM" id="CLU_018297_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-29-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="549" mass="60548" checksum="A6439756FF9110B2" modified="2010-05-18" version="1">MLERLTLWNIGGIRRADLAFGRGLTVITGESGAGKSSVVRAIELVGGKRGEVQLLRAGEDEGGAEACFGTDARFPELSDALQPEEGTLLARRTLLRGGRARSSLQGLQIPLATYSVAAARLLRIQSQFAQMELLDDARQLAMLDSCTSREARDTARELCRVFDEARARSQELRAMSRRREEIERRYANAQEVLALVRKVAPEPGLEAGLEASLTELARRIVRRERAQDALNRLFGGLSEPGLLDGVKNAVETFQELLPDEARQRVQQRLREGLHAIEDAVDEARDELSGQEEDAGERDRLEARLGALRRLKRLSSSADEEGLLTYCREASLNLEWLEKSYPKLEELTGESLKLRKRANALAMELRRSRQEAAAALSQRVNALLKDLAMEGTSFELHLRELGKLRRDGADEAEFALRDGTRVGRVDKIASGGELSRLLLALQLSLPQEWTPPTLVFDEVEAGLGGRAAVLSGMKLKELSRNAQVILVTHEASIAALGDAHVLIQRSGGESQIEAIEGEARVREIARMLSGSPDLAEAQEHARRLLTEGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M708</accession>
    <name>D4M708_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_00750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00750"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.174"/>
    <dbReference type="HOGENOM" id="CLU_015320_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-35-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005671398" evidence="1">
        <location>
            <begin position="27"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="108"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="234" mass="24791" checksum="F244072FE330AA2C" modified="2010-05-18" version="1">MRTMKVRKGFYGFLAAVLAAAVCASATDRAWAASAQGIISDSIDVLHDMAKQEDADAMADVLKDAHAVAIVPAMVKAGLIIGGEYGEGLILRREKGRWYGPSYYNLGGGSLGLQIGAQKISLVLVVTNEDGVRAFLNSRTKLGADVSVAAGPTGRRAEAATDAQARASIYSYSMTKGLFAGVSLEGSVISVSVKRNEDYWKKKLSADDALKQPAKDKRILPLTGALDNLARKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M709</accession>
    <name>D4M709_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00770"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.233"/>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-36-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="194"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="400" mass="43221" checksum="34FFDD468A71F894" modified="2010-05-18" version="1">MMNMLSRIKDLAREYERDAVALRRHFHAHPELSWQEARTTDRIAEELGKLGIPVLHRGYGGTSSGLIADIEGARPGRRVALRSDIDALPIHEENDVEYRSQNDGVMHACGHDGHMAGLLTAARILTQIRDELPGTVRLLFQPAEEDGPRGGARVMIQEGALQGVDGIFGLHLFSLYPTGKVLYRSGPCMASADGWDLVVTGKGGHGAAPEKAVDPVVAACTLGCALQTIVSREVAPTDTAVISITSVESSTKTRNIIPESVTLMGATRALSPEMQDRVEAAMRRIAEGVALTTRCRIDLNYMRFYPAVINDPKLTQILKETAEAMFGADAEEAPVNMGSEDFSFYGRAVPATFAQLGVGDPAQPGTRCPHHSPTFNLDEAQLKRAAALHAGFAWSFLNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M713</accession>
    <name>D4M713_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-Dimethylarginine dimethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_00820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00820"/>
    <dbReference type="HOGENOM" id="CLU_057463_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-40-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="37166" checksum="901C0B99EA4FFAE8" modified="2010-05-18" version="1">MPNIAKTMIDLDAQLEHGQEMANVKAIPGERWFSLETRIEEDFKEYWGGDWGCSSEYARLRAVLLHRPGKEVEGFDPGAVRFREAVDPEKFRSQHDALAQYYRDHGVQVFYTPGVREDRPNAVFCRDKLFMTPEGAVICRLGMAERRGEERYVAQACADLGIPIVKTIAGDGIFEGANAMWVDRRCVILSLSVRANRSGYDQMASELTRQGVTDVIPMQIPYGHCHIDGLLNIASEDTVLIHAMQVPYEVVDRLKKKGFKVLETPSLTETKYGYATNFVAIDNGHVVTSNQAPQAVELLERNGIKVDVLDLSELNKGRGSVHCMTAFLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M737</accession>
    <name>D4M737_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RND family efflux transporter, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_01170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01170"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.387"/>
    <dbReference type="HOGENOM" id="CLU_018816_14_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-64-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="425" mass="45590" checksum="2FECFA589855E630" modified="2010-05-18" version="1">MKVFKMLSFGAIAAGIAWGVWYGFFRDEGTEYVYRTQPVTRGSISATVSATGSVNPVEMVDVGTQVSGTIKEIYVDYNSRVTKGQLIAMLDTDMLQSRIEEAKAALALAQARTTSAKASVADADRTFKRNKELWGRDLIARSELDAAETKLSLARASLAENNAQVVQAKASLKQAETSLGYARIVSPVDGVVIARKVDVGQTVAASLQTPTLFSIARDLTRMQIEASVDEADIGRIAEGQRAICRFDAWPDTTFEGTVTQVRLKSTVVSNVVTYTVIIRVDNSELKLKPSMTANVTIVTEEKKDALKVPAAALRFTPPGDVLAALSDASGAEQEEEGEGSIMGLPPMRRRNGVRSGDEDEPVVWVVEDGKIVGSVPVGEQGISDRTWVEVLNTQLKEGQELAVAFSTAGAAVAAEGEAVVVRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M738</accession>
    <name>D4M738_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_01180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01180"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.388"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="243" mass="26260" checksum="10FB63139260D0DF" modified="2010-05-18" version="1">MSLPDAASERAACPLIEVEDLVKVYRTGDVELRALDGVSFSVAHGEFVAVMGPSGSGKSTTMNMLGCLDSPTDGRYLLDGRDVAHLSGDELAKVRNGKLGFVFQGFNLLPRLSAVDNVALPLVYAGVPARERRERARGALERVGLGARLEHRPNQMSGGQQQRVAIARALVGRAPLILADEPTGNLDTRTSEEIMDLLVEVNREGKTVVLVTHEPDIAAYARRILKFKDGRLVSDETASGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M744</accession>
    <name>D4M744_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED</fullName>
            <ecNumber evidence="1">5.4.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_01300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.6" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01300"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.554"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-71-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008801">
        <property type="term" value="F:beta-phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="224" mass="24797" checksum="A3E08BED15046FA2" modified="2010-05-18" version="1">MLSAVLFDMDGLMFDTEALNLRAWAAAGEGHGYAITPEVMHDQIGLSLPKTRSMMQERFGPAFDFDLVRGDRIRWTERWIEEHGLPEKPGLRRVLAWLIERRVPRAMATSSDRGIVGFYLKHTDVGECFDLILTGDRVEQGKPAPDIFLKAALELGADPAGCVVLEDSYNGIRAAHAAGMMPVMVPDLLSPTPEIAALTYRVVGSLNDVIPVLEALADERRPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M748</accession>
    <name>D4M748_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-class molecular chaperone with C-terminal Zn finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_01400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01400"/>
    <dbReference type="HOGENOM" id="CLU_764906_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-75-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="342" mass="38517" checksum="A67B971720F672F5" modified="2010-05-18" version="1">MEMNLFGEVKASLRALGLEPGATEADVRSAFRRLALTCHPDVVGQGGALRFQQIAGAYSLLKGLAPDELRQLSGAGWRQQRSLVKRRTSTFLDWYRRRRDRARQEAEEARRAEREEERRQAEERSERVDRVLEQYDRSLSRRLERMSKSADAAQLNDVLSRLGSSVAEVRRLALGRVGTLINRAEVRQAVSDLLCRWDVDEKTARLVGALPMEAGVLRRLAADVASRADQFPNSLVMSLLALRSRDVSPDPILMERYLVSVRPDCVAAILRYWPDDSAPSDAALRRLLGSEDAQVLVPLLSAMKQRFPHAVPHFRGRLEELLEHPAPAVRVWCRVLLAQGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M763</accession>
    <name>D4M763_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, linocin/CFP29 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_01570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01570"/>
    <dbReference type="HOGENOM" id="CLU_089875_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-89-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="274" mass="30515" checksum="D4F0AC45D2684DA5" modified="2010-05-18" version="1">MDDFLGRSASPLDEEFWSALDRTVVETAKGLLTARRFLPLCGPLGAGVQVVPVDRPVRTERTEDGFTFAEGRTYVELPQLTEDFWILWRDVEAAKREGLPLDLHAAHMAAQALCRREDRMVFYGVKRLGVEGLLSVGGTNVLDRGDWSAGESAFTDIAAGMAVLQQKGRIGRITLVLSQDLFVQLHRIQPGTGLTEIERIRSLLEGRLFQTPVLQPGTALLLCPQPQYMDLVVGQDIRTAYAEQLDLNHRFRILETACPRIKSPDAVVVYRSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M782</accession>
    <name>D4M782_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgA</name>
        <name evidence="10" type="ORF">SY1_01890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.979"/>
    <dbReference type="HOGENOM" id="CLU_009583_18_2_0"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="302"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="487" mass="54104" checksum="5A4B640A2DD770FB" modified="2010-05-18" version="1">MSGAGGEAVKVLFVTTELAPFSKVGGLGDVAGSLPKALCQAGMDVRVVTPAWPGVLEKVAAAGIKTTAMSRPACAAYNWQVREAKVVRAEVDGVTVYFLSAEDYTGDMYPRQLDFWTVSPFAVFCMQALELHRATGWRPDLYHCHDWTTAFLPCALAWHRHYRYAGERSVLTLHNVEYQGVFDPHPFMEASGLEPWSFNLSALEFYGRVNLLKGGIVATTAVTTVSPTYAGEIQTHESTRELADVLYQQRGKLRGILNGIDTRYWNPEHDRALPARFTARDLGGKQACRRELLRRTGFDVETEAPVVVCVSRLVEQKGFNLILEALDELPALGAKFVFLGSGQGWIEGALERAAAAHPDYIRFFKGYDEPLSHLLYAGGSIFLMPSVFEPCGLSQMIAMRYGTIPVVREVGGLRDTVTDADSPEGGDGFTFLTCDAKGMLWALRRAVARFRDQPSWQIIVERAMKRDFTWTRSAELYKALYRETARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M796</accession>
    <name>D4M796_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02110"/>
    <dbReference type="HOGENOM" id="CLU_2915846_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-124-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="61" mass="6357" checksum="D1FD81E251788134" modified="2010-05-18" version="1">MPLAMVAAEAGAGPEALARRYRVSRQAMALRLRSISALVRAERPDPLTAALSCGGTFCPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M797</accession>
    <name>D4M797_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M78 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_02120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02120"/>
    <dbReference type="HOGENOM" id="CLU_2105403_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-125-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="2">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="115" mass="12533" checksum="BF9C4C5550EC5052" modified="2010-05-18" version="1">MFQDGLLGPAREAAASLLRSTMPRMSAPPVSLSVICDHLDIEVYAQPCDAFGALLAEVRGRRVLMVNTSIPLVRARFSIAHELGHALLGHRSALERPSLSDERQDARPTSSRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A0</accession>
    <name>D4M7A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FlaG protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02180"/>
    <dbReference type="HOGENOM" id="CLU_1934956_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-128-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005186">
        <property type="entry name" value="FlaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035924">
        <property type="entry name" value="FlaG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03646">
        <property type="entry name" value="FlaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160214">
        <property type="entry name" value="SSF160214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="130" mass="14065" checksum="13D023D0AF7F9D17" modified="2010-05-18" version="1">MQVNLSAKAVLPAAPEGLPAAGGGVPEGVRPPEAAQAAPDVLREDPAASPEREPDRDAQKDVLEKVLEVVNLLAPDRHLKYEVIEEADMVQIQVVNNEDGQVVRRIPADEIIEMVKQIHKALSERLDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A3</accession>
    <name>D4M7A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02220"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1633"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-131-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="257" mass="26299" checksum="F1A5E82D246E4482" modified="2010-05-18" version="1">MEDRISLEGKVAVISGGAGGIGLGTARVLGRHGASVALLDLKAEAGEAARAELAGMGIDAMFVRCSVTSEAEVTAAVDAVVGRYGRIDVLFNNAGVTVRKTVVDLTEAEWDFVLGVGLKGTFLLSKHVIPVMAKGGGGSIINTGSGWGLKGGDKAAAYCAVKGGIVNLTRAMAIDHGPQNIRVNSVNPGDTDTDMLRDEGRQLGEEEGAFLRDSARGRPLARLGTPEDIGRAVLFLASDLSSWVTGAALVVDGGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A5</accession>
    <name>D4M7A5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="2">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_02240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02240"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1635"/>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-133-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="171"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="528" mass="59212" checksum="BD4E42AEA05C47B2" modified="2010-05-18" version="1">MDKIADKRDTSLTKFHQASWNEPIIYELSVKGQRGVLVPQVSEKVALEVGDGVSSLPACMRRETPPDLPEIGQPQLARHYNHLSQENLGVDSNIDIGQGTCTMKYSPKVNDRLASGPKVADMHPLQPDGTAQGILEIVWRLGRLFGEISGLECFSVQPGGGTHGVLALASIVRAYWQKRGEEGRDTVITTFFSHPSDAACPIVKGYKVIVLPPDEEGLPDLEAFKAALDEHTAALFMTNPEDTGIFNRRIREFTRLAHEVGALCCYDQANANGLLGITRTVEADFDMSFFNLHKTFSSPHGCGGPAVGMITCRKEFRDCMPVPLVEHSPERGYYLDFDLPHTCGKVKSFWGVAPVVVRAYAWIMSLGAEGLKEASRVAILNNNYCMKRILDIKGASISFPAHAPRVEQVRYSWQKLKEDTGFGTADVSRRIPDFGTHYWSSHEPWVVPEPFTIEPSESYSREDLDAYCDVLKEIARECYEEPEVIRAAPLNSTVHHTSHDYFDDPERWALSWRNYRQKYTGYFQPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C5</accession>
    <name>D4M7C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02490"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1706"/>
    <dbReference type="HOGENOM" id="CLU_101764_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-155-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032479">
        <property type="entry name" value="DUF5058"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16481">
        <property type="entry name" value="DUF5058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="243" mass="25656" checksum="475DFCF92271B062" modified="2010-05-18" version="1">MQDGQSYLDIANSSIIWMLCAITVGIAFLQAILFMCMARRTRLRAGIPAEISSKALRVGLITSIGPALGVFIVMVGLMAAIGGPMAWMRLSIIGAAPTELTAATYGAQASGVELGGTGYDLTVMSVSWFAMALNGAGWLVFTGLFTPAVEKLREKASGGDSRWLVVLSGACSLGIFGYLVHGELRKSSGHATAAIAGALCMLFLVKFVVPKCPKLMEYSLGIAMLFGMACALVYDMYFAVMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D1</accession>
    <name>D4M7D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ-class molecular chaperone with C-terminal Zn finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1716"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-161-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="304" mass="33222" checksum="AA93E83D81CD27FA" modified="2010-05-18" version="1">MAVQYKDYYEILGVPRSASVDEIRKAYRKLAKKYHPDVSKEKDAEQRYKEVNEAYEVLKDPDKRQKYDTLGMNWQAGQDFTPPPGWQGGGAGGGFRVDFGGDAGGFSDFFKTLFGGGLSDLFGGAGGGNFSSAGGYSPVRRDSEVDLELPLEEVVRGGTHTMVMTAPGGERRELNVRLPKGVTEGAQIRLPGKAAGGGDVYVNLHLAPHPVFSVSGCDLTREVKVAPWRAVLGGDVQVETLTGSVTMKMPPGIQDGQRLRLRGKGLPKRGSGNGDLYVRVRIEIPRHITDRQRELWQELERSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F6</accession>
    <name>D4M7F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02920"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1771"/>
    <dbReference type="HOGENOM" id="CLU_120866_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-186-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="183" mass="19509" checksum="39AC0AA2F1C95AA3" modified="2010-05-18" version="1">MVLLAHCILNPNAKIAGAAQTRGAIPGVLEGLLQDGVGIVQLPCPEQTFGGCRRWGMTREQYDVPCYRKHCRSLLEDVVDQMEDYLRNGYEVLGIVGVDGSPSCGVDRTCAGYKGGEIASMPSLPSFSCVDGRGVFMECLTSMLQSRGLSIPAVGIDEGIQEALSWKELLKGLRGGSARPCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L4</accession>
    <name>D4M7L4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">SY1_03970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03970"/>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="49" mass="5733" checksum="AA6D2F1AAD767EC2" modified="2010-05-18" version="1">MADIIGLTCTQCKRRNYTTTVNKKKQSKKLEIKKFCKWCNASVLHKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7M3</accession>
    <name>D4M7M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_04100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04100"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1895"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-254-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="288" mass="31185" checksum="4954E33545CF173F" modified="2010-05-18" version="1">MGQIFASLRRRGAWRKGYKLILGNSSLTIGLAIVALMCIVALVPESIATHSPNDHNVDAILQPPSAEHYFGTDNFGRDLYSRVVWGARVDLQLGLVAMIVPFVVGSLIGLLAGYYGRWIDALLMRILDIFLAFPFTLVIIVIVAIIGPGTANLYIAMWLVGWRTYARLIRSEVLVIRDAEYVQAARVLGYSDARILLRHILPNVVSSCIVYGASDVVMCMLAGAAMSFLGLGIQPPTPEWGALIAGGRAFISKAWWLTALPGLCLAIVGTGFSLVGDGLSDLLRTKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P4</accession>
    <name>D4M7P4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SY1_04440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04440"/>
    <dbReference type="HOGENOM" id="CLU_001114_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-275-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="17"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="521"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL27889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1213" mass="133596" checksum="AE8BA9168131426A" modified="2010-05-18" version="1">MDRDAASSFWDGALLPDGTPEGQRAAVTSSDGLITVGAGAGTGKTWVLSNRYARLLLTDADCLPCDILTLTYTDAAAGEMRRRIEDRVRALMDVPDAPVSQERRREVLEGFSEAWISTIHAFAARLVRESGLALDVDPRSAVVSGPQTERFWARVRDALEEAGLGELADACGSSHLRAVARELDQDPLISAAVGRWGAEALKDLAREAAELHADLGHRWEDMMRWGDEALREDDPQARAAGREVLALLRLSWRRAWATWRDVFDALAEDIRAAGAAAQASGRNVPDRLLMEFMERWEGRLSGPEAADDELRTFYLEVMDRERLKGGNSGLLKKVKEVLGTTLGAWQEAEEDEGTPALSAPSPDAPLPEPERLMRSALLRFCAAAWGLWDAERRRRGLLSFSDMILQARAAVESGKAQRTFRHILVDEFQDTDPLQFGMIETLRHEGVRSLFAVGDPKQSIYGFRHAEPSLFAEAIGRADARVTLDVSFRTRGALLTRLNDLFAHIWRDGLGTSEAMSRLEFEPLSPAGSGERGAGTTAPFSVLLAVKEGRAVLGARRRLAGALARRVARWVEEGRTVWDKGLNALRPLRYGDFAVLARTRGSHELLEDAFAAAGVPAVQDRSRDYFSRGEVTDVICLLRAAEDWEDGAAVFGWLMSPFSGVPIDEARRCLERIGGTLRTGRGVMEALKEALPDAAARLERTSLIGRRNGPAAILSPLDRDRRWLANLPEKERLRALRNVRRAVAIARSFQRGSASSLAACADWMDRALRRGVDMEEPAWHGEGVNAVLLSTVHASKGLEYPVVAIFDTAKRRRPRTLCPSRTLGAAFADLPDELSASRPSAREPLSMAWERALTRQGEREEDLRLLYVAATRAQDSLIHCGLVTFGKEGSAPAEKGGWTSIVLDWMQGRGDCGPDLTGPDVELIPSGDGAQPAGKPQRAVPTPAPVAVARPDSGTRELAVLSATSFSLMEWCPLAWRRRYRQGLDLAWEAPRGAAEEDGRGGSDLGSLAHWILARWPSAEGDAEAELERWLTDPRALRSLPTLLRDVWREEENRNALRPWLLHFVGSEAGVMVRGALPLGARREAGFRVEVGGLALSGAMDVVWREGEIWRVLDYKVTLMQNAPEELYSAQLDLYALAARKGAELAGAPCRRVEAGLVFLRERSPLRMRKVEDWEAIEGRVRAAARLGAVRDLPPREEHCPRCPWRSSCPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P6</accession>
    <name>D4M7P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized domain HDIG</fullName>
            <ecNumber evidence="8">2.7.7.19</ecNumber>
            <ecNumber evidence="8">2.7.7.21</ecNumber>
            <ecNumber evidence="8">2.7.7.25</ecNumber>
            <ecNumber evidence="8">3.1.3.-</ecNumber>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_04460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="8"/>
    <dbReference type="EC" id="2.7.7.21" evidence="8"/>
    <dbReference type="EC" id="2.7.7.25" evidence="8"/>
    <dbReference type="EC" id="3.1.3.-" evidence="8"/>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04460"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1931"/>
    <dbReference type="HOGENOM" id="CLU_015961_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-277-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="177"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="7">
        <location>
            <begin position="298"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="456" mass="49472" checksum="5903FCF66A8080FB" modified="2010-05-18" version="1">MEITPAALKAVAALRHAGFDAYPVGGCVRDSLVPLIGTPQNPSDPASVRAILDCAPSDWDIATNAAPEHVRSILGGRLAAKPGLRHDTVMTSVDGTPVEITTFRGGAATIEEDLACRDFTVNAMALNADGRLLDPFGGANDIRSGVLRAVGDPAERFREDGLRILRGLRFAAVFGWDIEPDTALVMHMEKDLLRDIAVERTRAELVKMLCGVHVGPVLRKFWNVLSVAAPEIAPTVGFRQNNRHHHLDVWKHTIAVVEAAPAVPILRLAALLHDLGKPACYTVDAAGIGHFYGHAARSAEIARDIMARLRFSDEIRRRVVTLVEHHGDILTDTPSRRTVRRMVSNLGVDVFHDLLALRRADIAGHKVETCGKAMAACVRFEELLAELEAENACFSLKDLAVRGGDIMELGYRGPGIGKALRALLDAVVEERVPNEREALLELLRHDVMPGLDGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q8</accession>
    <name>D4M7Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FOG: Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_04760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04760"/>
    <dbReference type="HOGENOM" id="CLU_428113_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-289-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="639" mass="69299" checksum="3F1DE6719F45A33D" modified="2010-05-18" version="1">MFCTKCGAQIGDEAAFCEQCGARTRRGQSSDPASNPTEETKPHRRAPSPISDFMAWCMVGLECAIALYLGLYVFQNGFFINSTGYEVPQYLAFLADCALRLLCAKMDSDVLTAKGYPAPSIAWAFFFPPIYLYRRGKALQRPHTLPALLSFAAMIASTGIFVSAEIRRAEVEATASRTVSGIIRERFSMDVQCLKVKLTKRLFKGNYEALAQLSNGRALPIQVLEQQEDVFVSLRPAPLLLDELFSNLLSLGDQDTFSPAEAESVDEKSRDRRNATNLVSSLRSLKAATFLFYADHAENGRERKVMELVNGQDGIAQLKAYLDNPERYGERYSISLWDASDGSQRLMVVCDLSGESEGVRQALQERARSVGLYEGRSQSLDDFYAGGDSVCMVAMPVNLDMTPRITQAQRAELSDAFRSGSAARLKEVLQRERLSPDMMFEDGELLLRVAVKESPNADTIKALLALGANVNAERRDGRTALTAAADGGPLDVVKALLDAGANVNAKNRHTGWTVLMFALKEANPDVVRLLLNSGADVAAENSDGQTPLAFAVLQGASTNVLKMLLDAGADIEARDGDDNTPLILAAQYTSNPDVLLVLLDAGADAGARNAAGLTALDLASTNPNLDGAPALQKLRKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R7</accession>
    <name>D4M7R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04920"/>
    <dbReference type="HOGENOM" id="CLU_1793668_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-299-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="144" mass="15599" checksum="78CE1FD238C589D7" modified="2010-05-18" version="1">MSGMTRWGLFLAGLFAGATGGLFYLDHVVAGALCLAAASGALWFALRRREAEEPQERGMVSDADLSELALFVAELAVSGLKGVGRTIPPSTKEIEQLEGRLNVLLDHMGVSDASRADLRSEFERIKGRTRRNEGGIALIRSRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R9</accession>
    <name>D4M7R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_04940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04940"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1986"/>
    <dbReference type="HOGENOM" id="CLU_808084_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-301-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="37290" checksum="D2453775848911DF" modified="2010-05-18" version="1">MEQSMEGLLLSFDERYPCWTPAMLALAELDRTAADDLTREGLLEFGEGAYSLSPTGREAFLKLAGEACLPSRPGEAPDRKRAARWGELMLLLDKRHLQRWGVKEYVAPFRFALPNVRGEDLFVMDGAAPGWRYPDAPVFRRMAEDFPETGVAARTRPMPGAEEVRAWLAANAPGLRDAEFDLLYKSRYDFQDYAKFPPLPADPCGLFNADHFLFAFMPPPAPESLPEYLEKVGEFQMFLTMLRRLYLPGYVDLDAMDQDGVNWLLFAFTEERDAERCVKLLGPIAEALPGPAAPLELWSVSLEGLRDYPGGQAETIWDILPFAAHSIYRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T5</accession>
    <name>D4M7T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05170"/>
    <dbReference type="HOGENOM" id="CLU_2422682_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-317-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="91" mass="10134" checksum="92811A9437CD0E22" modified="2010-05-18" version="1">MRLIDTRVILGLSLWILGFALMTAGWLVDALFEGWGRIPSKVLYKLGALIVAVPVIVLLWRASRLLYVHRIDIVLGINNAASFLTEAMKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U4</accession>
    <name>D4M7U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05300"/>
    <dbReference type="HOGENOM" id="CLU_070764_7_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-326-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="170" mass="18737" checksum="F9BA9938B31F5CD5" modified="2010-05-18" version="1">MLEAMRRRRSIRKFEGRKVEDGDVTRLMDAGLVAPTGKNTLCTEFFAVTDKAKIERLAQCRDGMAASSLRTAPLAILVAGRHKDSDVWREDASAAAAFVLLEATEMGLGACWVQVFQRPCGSGTSEEAVRRILGIDPEFSILCAIAVGYPAEEKEPRNLETLDRSRAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X3</accession>
    <name>D4M7X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_05680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2061"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-355-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="313" mass="34282" checksum="637449BED019D5AE" modified="2010-05-18" version="1">MKTYIVKRVLTAAATLFAIVLALFLMLELMPGSPFNDEKLSPEQVAVLREKYGLDGPVLIRFARYVGRMMTGDLGVSYNIQKNVPVTEMIRARLPISIRIGLQAVFVGAVLGLLLGVLAALRHNSIADTFSTVVSVLGVSVPSFVFAFVLLYYLGFKAGWFPTLYKVNRPAASTVLPTLALSMFTLAQIARFARSEMLEALGSEYMLFAQSKGLSPFRTNFVHALRNVLIPIITVLAPLIVNLMTGSMVVEKIFSIPGVGSLLVTAIQSNDYNVVISLTFVYCVLYIGLMLVVDLLYGVIDPRIRLAGGKRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X6</accession>
    <name>D4M7X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Co2+ transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05760"/>
    <dbReference type="HOGENOM" id="CLU_089873_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-358-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061833" evidence="1">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="262" mass="28418" checksum="A7F6D43095440C86" modified="2010-05-18" version="1">MKRGNKVVLAAGLLLGVASAAFAHELVMKPQKMNAAKGETLAVEIHSGHKFIVPEEVESVERIKAGVFKDGKLQEAGLKPNEKNLCIDFSLPVEDASQSMVILANKDGGVWCVTNEGGKSGLRKDLEAQGLKVTKATKNDKFVKVIVNASRDDKNFAVQTGQALEIIPVTNPADAKVGEFFEVKILVDGKPYSGAVWASYDGFAPEYEDTYAYYTQAVQGVAHIKITAPGLWGVRAMKTDLPGKEGEYDSVARRTFLLFEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y7</accession>
    <name>D4M7Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FOG: Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05970"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2085"/>
    <dbReference type="HOGENOM" id="CLU_573368_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-369-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="476" mass="53800" checksum="56E924B2D28D4531" modified="2010-05-18" version="1">MKLTEYLKQVVNDEQWVYKEDCDLYACGITPDIVDEELLLKVASKLHKQKERESFWNDLLDYLPEKSLTQNVFAYLLENKIALVSLAHRRSDDERLKKLIPYAEEALFTLAKRYYGQSEYYPSDFNGESKYSAEDFAGFLCEYYYDALLEQLGSLKPDDPEKEIILFYFYSNKHRPDVEKLIELRCLEITNDPVMIQSAYERNDPLCFLALSRNMFATRDMLESLGNASDIENASCIRSNARKTLSIKKYLDSHEGTPQITTNKAYQDPKMAVECMTLLMRTVWQDTDFQLLNELLATGMDVNEKNVYGMTALMYAAWRDVPSIEVVSALLDAGADVNVKDEGGMTALMYSVWGEAPNAEVIGSLLDAGADVNVRDEDGMTALMYSVWGEASNVGVIRTLLDAGADVNAKDENGMTALMYSVWGDTPNVETIGTLLDAGAEVSMKDHEGKRVIDHARVNERLKGTDTLKRLENASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y9</accession>
    <name>D4M7Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06000"/>
    <dbReference type="HOGENOM" id="CLU_728900_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-371-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014555">
        <property type="entry name" value="RecF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029347">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="24"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="377" mass="43646" checksum="7E06CFFDA05D2020" modified="2010-05-18" version="1">MIRKLEIHNYKLFRNFALELDGGVNLLCGPNGSGKTSVIEIVYALTRFLAIPDHSDTIACSVEDAFPFRTFCRWCTEENGWGEMSVKLEIESDEQPLYIYDLTVRYNFLEKISRVQHESLRLGEALLLRFQEGRIEMFTDDEKKLAFRSDWKRSGLVVGSSNNSRIRRFGKQVASLYAFHLVPALMKQDVEKPMETLALYGENFAAWRFLRATQQLMRQARVVEQSKYFIPGLVDIRYIKKGDWHALAVKVEFNGRENDIEFNELSDGQKTLLALYSILANIPNGSTVLIDEPENFLALSELQPWLEAMNDAWEERDIQFIIISHNPRTLNWHNKNAMILSLEGTPPKVVVERRTDDDDDPLVDKLRLMEWEECDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z0</accession>
    <name>D4M7Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06010"/>
    <dbReference type="HOGENOM" id="CLU_055261_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-372-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="143" mass="16883" checksum="1DE441446CC13936" modified="2010-05-18" version="1">MTRRYALRDDQWERIKDFLPGQPGYVGANGKDNRLFVETVLFRYRAGIPWRDLPERFGDFRVVHTRFSRWCKSGVWKRIFETLAEDADNEYAMIDSTIVRAHQHSAGAKKAARMRKPLVAAVEVSAPKFMRRLMRWETPQAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M805</accession>
    <name>D4M805_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripartite ATP-independent periplasmic transporter solute receptor, DctP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06230"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2109"/>
    <dbReference type="HOGENOM" id="CLU_036176_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-387-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061007" evidence="2">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="337" mass="37266" checksum="24805A0D5E70D825" modified="2010-05-18" version="1">MKKTLALLLTLGLALSVISGSASMASATEAKFVLKLCTEQTDGDPIDDGCDRWAELVSKATDGAVKIQVYPSSQLGAKADLIEMMLMGQNVCTIADGSYLMDYVPDFGVVMGPFLFSEWSAMYQITDSDWWGEVAAQLEEQGLKIISTNWVYGERQLMTRSPVKSLADMKGLKIRVPNNDISVTMFNDLGAASTPMALSEVYTALSQGVVDGVENPLTTLYNNKFQEVCKNVTMTNHQMTFSNFIVGKTFWDKLPPKYQEAIVSCGKEAALYNNDLYQQVSQKMQQALTDEGCTIITLDEAAQAEFKDACVKLYKEYEEKGTWSKGLYDKIQAIINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M820</accession>
    <name>D4M820_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06450"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2132"/>
    <dbReference type="HOGENOM" id="CLU_095256_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-402-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="191" mass="21229" checksum="93F90EE953782599" modified="2010-05-18" version="1">MTDMLRSRAEELKGKKTRENLCTAFAGESQARNKYTFFAAKARAEGYNQIADLFEETAHNERAHAKMWFQILGGISDSTAENLKAAAAGEHDEWTDMYPTFAKVAREEGFNDIARLFEGVAAIEKAHEERYKKLLNDVEKGLVFSSDGDAIWQCANCGHIVVGRRAPEMCPICGHPKAYFMKKGEGGQAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M850</accession>
    <name>D4M850_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
            <ecNumber evidence="5">3.4.13.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_06860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EC" id="3.4.13.9" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2179"/>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-433-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="145"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="368" mass="40114" checksum="4AD99E1834F309C8" modified="2010-05-18" version="1">MAFEAVNKRLVRFRALLKEKGLDAFVLLVLERHNTENCHYLSGFRGSSAALVVDRENALLVTDGRYRIQAAAETPFEVVIQSELPLPAWLAKAVKDARWRRVGFEAEKVSHRIFSLSLEPVGIEWVDASELIPSLRRAKDAEEVEAIRRAALIGRQAYGNVLRTVRPGMTEAEFEGALLLEIKRLGAEKGWAHDDFIVASGARGAICHAHATSRAFEAGDVVTVDYGAMVGGYMSDITRNFAVGRPDDKALEVNDVLLRAHRAAAAALRPGLAGREADAIARRIIAEAGYGRNFVHSLGHGLGLEVHEAPRLSATSRDVLQAGDVVTVEPGIYIEGWGGLRIEDDYLITQDGAECLTATDNQSLEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M852</accession>
    <name>D4M852_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06900"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2180"/>
    <dbReference type="HOGENOM" id="CLU_011498_5_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-435-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="370" mass="41273" checksum="03948493022F6E22" modified="2010-05-18" version="1">MAAHPQRFFAANQFIDSDGHLLKPDDDQANRHNIELALMAATATCGFTILGGTNGGGKTHMAISFAKKITGLDAEVSADLLPVRSDWRNVGDLLNRQQTLGANGTFSGTAFYDALSACEITPQKRAFIILEAMDLARSEDYLTEVLSAMDMRNLALIPCPDGNFYRMPKFLFIIGTANADATTFPFSPRVLDRAFYIRFRVNDVMFTDDQSDDTALQSAKAAATFLAIIDGEMEEKLKAFRKKIRTDFQIEELLSAVNTIPGNHTVSLGYRTRDAIYNFMANFMCLSGQDAYNVDAAMRAFDWAVTTKILPKFQGSRDDLQAPLIALERELQSRGLLPYGPSGMWPWRTKDELTFLRYQMEKNAASAIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M870</accession>
    <name>D4M870_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_07240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07240"/>
    <dbReference type="HOGENOM" id="CLU_1308630_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-453-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="210" mass="22890" checksum="19A993BF73B55D58" modified="2010-05-18" version="1">MRVQFDLCPAEYLARRKKRHSFNATRILAVLLLLFFLVAGIGYIVMAFMETRALASDIEMVEDAVAKLEADQSELTAEIVRLKNKEQQYAKTLQIMRNEPPTIEALSALETNMDQGMGITSIRFAPGGTNEGGLVVYTADVDATALVEDQITALTTGLSGSGVFSGVTMPSSQKDEKTGRVDFKLHLELRPFGQIDMTGAADSTGKEPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B1</accession>
    <name>D4M8B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_07880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07880"/>
    <dbReference type="HOGENOM" id="CLU_2769892_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-499-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="69" mass="7897" checksum="68259F1E80A286F0" modified="2010-05-18" version="1">MKQKLFGCVFLVLLLLGALPLSMTWGEQGYLFGWLPVALAYWWTLMVVNLAFVLLVCRDFVRSSKKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C2</accession>
    <name>D4M8C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted oxidoreductases of the aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_07990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2293"/>
    <dbReference type="HOGENOM" id="CLU_023205_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-510-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="371" mass="41576" checksum="401075FED76ADDA0" modified="2010-05-18" version="1">MTCLEEGIKKLGFGLMRLPRDGDAIDVGQTKRMVDRFLAEGFTYFDTAWAYPGSEDAIREALVERYPREKFQLATKNAAWLECKTREDAVAQFETSLRQTGAGYIDFYLLHNLGEGRTHFFNDFDMWSFVQEKKKEGLIRHAGFSFHSTPEELEDILKAHPEMEFVQLQINYGDWENPAIQSRACYEMARKYGKPVIVMEPVKGGMLATPPESVANILRRADADASMASWAIRFAADLDGVLTVLSGMSDLAQMEDNLSFMKDFTGLSDAERRTLEEAREELAHIPLIPCTTCNYCSKVCPVEVGISGTFTAMNALTLYSDLAAAKHQESWLVGGHGRKRAAECVRCGHCEQVCPQHIAIRDELARAAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G5</accession>
    <name>D4M8G5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">SY1_08730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08730"/>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="61" mass="7257" checksum="7BAA51B1D7669BF7" modified="2010-05-18" version="1">MARKALKYKAKLPPKFEVRQHNRCPLCGRIHGYMRMFDMCRCCFRKLAREGRIPGVVKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I3</accession>
    <name>D4M8I3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="5" type="ORF">SY1_08970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08970"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.96"/>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-576-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="4"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="629" mass="70169" checksum="48F9077F87B82E71" modified="2010-05-18" version="1">MQAEKIRNLAIVAHIDHGKTTLIDSIFRAAQTFSAHTQVAERVMDSGAIERERGITIRSKPCTVEWGGYLINIIDTPGHADFSGEVERILSTVDSVILIVDANEGPMPQTRYVLQHALSIGMKPLVFINKVDREGADPNGALNKTFDLFFELGATDEQADFPVLYGSGLAGWAVKDLSDPRRDNMDDLFQAIIDYVPAPNVDPDKPFLMQVSTLAWNEYVGRIGCGKILQGHIRKGDPFVRVSTKWNTTDHTGTDWTTTGQENARVVQLWVTRGLERVEVDEVGAGDIVWLTGPTEIDIGDTFAAEAIADRPLKPLSIEEPTVSMFFLVNTGPFAGREGQAVTLRQLKARLQREMHVNVSLRMEDLGRPDGVKVSGRGELQLSILIEEMRREGMEFCVSKPEVIMETRDGVKMEPYELVTVDVPDEYQGIVFEKMSQRKGKVKNVVNQDRGLLRIEIEIPTRGLIGYRGEFLTDTRGLGIMSSCFSGYAPWAGDLVTRSRGSLVSLDTGEATAYQLENLQERGTLFISPLEPVYNGMIVGENSRPGDMPCNPTKRKQQTNHRSATKELTTKLDVPRRMSLEKAMEWIEVDELVEVTPQSIRLRKAILDELERRKATRRAGGESDPSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8J2</accession>
    <name>D4M8J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09130"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.116"/>
    <dbReference type="HOGENOM" id="CLU_065155_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-585-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="199" mass="23088" checksum="07F51DCF5F88219E" modified="2010-05-18" version="1">MNRIITIGREFGSGGRELGRRLADALQFAYYDREIITELARRTSLSEEYVQRIVEHRPTAAFPIHVGRSFYPMVNPMWEQGQAVYQEQHRLIKEMAAASNCVIVGRCADYILRDMRPFRIFVYAEMASKMRRCREKGEDAKAMSDKELTQHINDINRGRAKYYEFYSGQEWGGRLNYDLCVNTTQLDLAEVVAAIAKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8L4</accession>
    <name>D4M8L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, contains double-stranded beta-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09560"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.158"/>
    <dbReference type="HOGENOM" id="CLU_109382_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-608-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="209" mass="22741" checksum="9108BCDF29EED097" modified="2010-05-18" version="1">MKTGPFSLAAENPAVPGCTLSGKVIQDTFVFSMAEGTDISPESYPDHKLWLVVHGSMCVVAGREIPLGAGQGYVTPVGMPVGIKAEADSVYVEVSLRKETVMNPVLKDKEVFELKDLIPYQDGKIVNLDLLSSPKMKFVVMSFDEGTGLSEHSAPGEALVFALDGKAIIGYEGKEYPLRAGENFRFQKNGRHYVKADGRFKMALLLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N5</accession>
    <name>D4M8N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09890"/>
    <dbReference type="HOGENOM" id="CLU_3153143_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-629-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="48" mass="5511" checksum="120170BA18DFECAB" modified="2010-05-18" version="1">MGYLSGNNAVLEEPNRGTGYRNNQTFIDMIYPVARQLNLTESFFTHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R6</accession>
    <name>D4M8R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10460"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.256"/>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-667-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="120" mass="13783" checksum="CB30B10E52A7B255" modified="2010-05-18" version="1">MKGSKDSKTEDYAARCPLLYVMELIGSKWKLPILWCLNDEDGLHYNELKRRVHGVTNTMLTKCLRELEEKGLIFRHSLGSVPPSVTYHLKEDGKSLMPALEGLCSWGMAYLEKRRERPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S0</accession>
    <name>D4M8S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar biosynthesis pathway, component FlhB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10540"/>
    <dbReference type="HOGENOM" id="CLU_041013_4_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-671-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="95" mass="10388" checksum="4CCADF9615B90096" modified="2010-05-18" version="1">MAEAKRDQAVALKYDRETMNAPTVTARGEGFIARKIVERALEADVPVLEDAALVSALLSLELGEEIPAELYTVVARVLTWVYRVDREAAGGGRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S1</accession>
    <name>D4M8S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10550"/>
    <dbReference type="HOGENOM" id="CLU_818704_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-672-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="364" mass="38939" checksum="071F2511E82C29ED" modified="2010-05-18" version="1">MPPVNNLINQNLTDPSRTSAGQIAVGQQAEALQATPSRAPGLRTGTVVTGRVLAGNPDGTYAVRIDGQDANPPLELRARATLTLVPGERFTALWDASGGGVPVLRLSKEELSFLAQIPQRDRGLATALLSREMPLSGEVLAVIRDAWRRMGSDEGQIAPLVELWARGVSLSAENVSLLAGYTALDAAAASEMWNRIRRELRERTRKGQDPLEALREMKEGNGEKARFLQAHSLLMRAPRKDVNPMLLAAPFWPLPEAAGGMTARVFVGRSAEEEGQRYWQAGFGLTGSALGAVAGVVETDGRGCNVLLTAESAAACGLLEARRGELRQELAGAALLVRFIGISRGAPQEMRERLLAGRGLDVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S6</accession>
    <name>D4M8S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SY1_10660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10660"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.273"/>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-677-MON"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="317"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="450" mass="48219" checksum="6367C56814C4E47A" modified="2010-05-18" version="1">MKLAVIGTGYVGLVTGTCLARYGSTVACVDTNGERVAALRSGRVPFYEPGLDEMMARNAAEGRLSFTTEAAEALEGADVCFITVGTPSAPDGSADLSFVEGAARSVGRGMSGGLLTVVKSTVPVGTNARVRDWIREELEARGARHALNMASNPEFLREGAALRDFVEPDRVVLGADSPEAAETLRRIYSFLEPSKLLFMDIASAEMAKYAANAMLATRISFMNEMACICSRVGADVESVRQAMGRDDRIGSKFLRAGCGYGGSCFPKDVRALRDFARATGYEPNLLTAVDEVNTRAKGLLLEKLRGRLGDLSGRVIALWGLAFKPKTSDTREAPAQVLIHGLLAAGASVRASDPRAIEETRAALGDLPNVTYVPDPYEAARGADALAVVTEWDLYRQPDFVRLRSLLRTPIVVDGRNVYSREEMERAGFDYLSVGRPPVLAASGPAGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V1</accession>
    <name>D4M8V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SurA N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_11050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11050"/>
    <dbReference type="HOGENOM" id="CLU_816194_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-702-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="172"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="368" mass="39883" checksum="5C2A591B36F54A76" modified="2010-05-18" version="1">MLKNLRTHMKWIMITIVVAFLLSTFLMYEGRSGRRGPSRSADGTMTDYEVAAVDGRPLMRSELENRLRAYLENSGLRNAASLDLPAVYQAVLDQYVLERQLESEVKKADIAISDADAEQAMKAYADSAFPTREAFYAALERQGISSAEYKKSLARQLAVQQLLHMAVGDVTVSEDEAVKFYDSIKDQLFRTPAGVNLQVARFGASADAEALRAKLQAGTDWVQATSGDALASMDVLSVTREPLFLPESAFESGVLAELASLDVGAVSPVFSPASGDFSVAVKTERVSESVRPYEDVSSDVRAFLRSQEERRKLNDYEAALMAKAEVVIYDASLFPASADTTASAEPQAVSTDASASADVEPASDDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Y1</accession>
    <name>D4M8Y1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.356"/>
    <dbReference type="HOGENOM" id="CLU_626649_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-732-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="277"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="437" mass="48853" checksum="B65554F44B34A32F" modified="2010-05-18" version="1">MKTTNDGFSYRVFFERVFDPIAMYRVAGAPAKGAWGGSDFLRMKGESHERAGGVRDLQDQENCHRGISEAAIAGYSSEALHGPDRCERGGEDLLFGRPYAPLRLGRWEVGRNPVPIRRGRKAVDSWQMRRNGVGRRYGGARLRASEVSASNGAQGSRLFHNPGDAVAAEVGSSQAFFYIDAHHGRVEYYNTETKRLDVPDWDYNPGETALSQVPRMFRQPEALRRVLATATQYHTLDVGSRAPIKLPQPVKPADLPGANGEALLPFLYSLRESDRPRFDAVTDALRAAYPDFEELTFPPAAAGMLALSWKDKKFESPIYADELSEGTLRFLWLTALLQSPELSTVTMIDEPEVSLHPELLDLLAQLMREASARTQLIVTTHSDRFVRFLKPDEVYVMDVGEEGEATITPADTLDLARWLDEYSLDEVWRMGRMGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z2</accession>
    <name>D4M8Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted DNA-binding protein with PD1-like DNA-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_11750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11750"/>
    <dbReference type="HOGENOM" id="CLU_114051_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-745-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061844" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="2">
        <location>
            <begin position="36"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="174" mass="19209" checksum="0A772F7CA3173350" modified="2010-05-18" version="1">MKKFLFGFVLCLMMAGTCFAVDSGDAVKADISDAVPSNARFYTIRLVPGTDVVKELRAFVDKKGIQAAAIVSAVGSLSEANIRFADRSEGTLMKGKYEVIYFGGTLDAEKHHLHLSIADEDGRMWGGHMMKEGSITRTTMEIVVMELTDVVYKREKCPISTYNELVVYPREAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M905</accession>
    <name>D4M905_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type amino acid transport/signal transduction systems, periplasmic component/domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_11920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11920"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-758-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061845" evidence="4">
        <location>
            <begin position="24"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="33"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="277" mass="31357" checksum="5DC723FBB0B2139D" modified="2010-05-18" version="1">MKKALLSALILGLGFVVCTAAVAAAAEKDAERVIRVATPGTYAPFTMYDELTQEWSGFEIELWRLIGEKAGYEIEFVRLDLPATFAELDLNRVDTVAKQISITPARQQKYNFTQPFFFSPYYIIVAEDNNEIKSWKDMEGRSIALAEGSAMNEFIAALDPENKVKKSVYESDKLVFQEVSVGRVDAYPGPYVELLDVLKRNSSLKLKAVDMENPIYVEVNAYPFARTDRGRALLKLTDGILTQMIEDGSYAELCEKWFGMNVMDSRYAKEYREKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M924</accession>
    <name>D4M924_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12130"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.449"/>
    <dbReference type="HOGENOM" id="CLU_009273_4_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-777-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="375" mass="41899" checksum="01D3BCEF12262097" modified="2010-05-18" version="1">MQIHREKDFLSCFDDRTGRYFRTGIIRDGRDTGEDPFMSSFPELVDVGIMGHCRHGKLGLCRAAGVECYQDGPHSDAPDMELDDFLELARQCSSRTYQFALGGCGDPDQHENFAEILQICRHYRIVPNYTTSGLGMTKDIAELSGRHCGAVAVSWYRSTYTLRAVSLLLNAGVKTNIHFVLARDSVAEAIRLLTGKGPSEGFPVGINAVVFLLHKPVGLGSREKVISLEDESFKEFLKLVNSRTFRYRVGFDSCTVPALVNNPGIIDMKSLDTCEGARWSAYVTPDMKMLPCSFDNQDRRWEVNLRDNTVEAAWNSSTFEDFRTCLRTSCPECDKRSLCMGGCPVRPEIVLCGRRLDFQRQIDNPGTTGKSSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M930</accession>
    <name>D4M930_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12210"/>
    <dbReference type="HOGENOM" id="CLU_107928_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-783-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="119" mass="14106" checksum="353BC49653D36309" modified="2010-05-18" version="1">MPLLPRNKNLLGYARLLRREMTPQERRLWYEFLRDFPMKFYRQRVVGNFIVDFYCASFKLAIEVDGGQHCDEAVVKYDLERTKFLKSLGITVLRYTNLDVAENFEAVCVDIENFVKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M940</accession>
    <name>D4M940_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">SY1_12370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.477"/>
    <dbReference type="HOGENOM" id="CLU_061901_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="182" mass="20570" checksum="2D2844EBD16E635F" modified="2010-05-18" version="1">MIGYMTIAQEKTRPSRGELLGVELEVRRYPDPVLKKVAEPVTVFDDELADFVGKMRTVMRVSDGVGLAAPQVGVLRQIAVVDYKEEAYDLINPRVLEQGGEQEGEEGCLSFPGIYAMVRRPEWVRVEAQDVRGEVHVHEASGFLARAFLHEMDHLNGKLFIDYLSPLKRGAIRRKMMKKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M952</accession>
    <name>D4M952_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family (TC 3.A.1.4.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_12680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.501"/>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-805-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="293" mass="30591" checksum="6D918C09AC3AFE52" modified="2010-05-18" version="1">MIFLSFIISGISLGSIYAIIALGYTMVYGIAKMLNFAHGDVIMVGAYVCFYAVARYQLPAVAGVALAMFVCTILGIVVERLAYKPLRQAPSLAVLITAIGVSYFLQNSALLLWTSNPKIFPSVVGKGTLKFFGGQLSISYVTIVTVVTCVVIMLALTWFTGRTRMGKAMRACSEDKGAAQLMGINVDATISMTFAIGSGLAAVAGALLCSAYPTLMPTTGSMPGIKAFTAAVFGGIGSIPGALFGGLLLGVIEIFAKAYISTQLSDAVVFAVLIVVLLVKPAGLLGVQVQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D2</accession>
    <name>D4M9D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mreB</name>
        <name evidence="4" type="ORF">SY1_14080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.640"/>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-888-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="351" mass="37037" checksum="3636E322F723A6BB" modified="2010-05-18" version="1">MFKYLSGVLGLDVGIDLGSANIVVYVKDKGIVLSEPSTVAIRKLPRGGGLEVIAVGREAKAMSGKTPGGVEAIWPLQDGVIANFDMTEELIRYCLRRAGGSGSFMVHPRVVISVPAEVTEVERKAVVDATLGAGASEAYVVEEPISAALGVGLPIDRPNGCMIIDIGGGTSEVSVISLGGIVVTSSLRTAGRTMDNAIIAMIRQRYALLIGETTAEEVKNTIGSALPLSPELEMSVKGRDLSDGLPKSDMVSSLEVREALEPIFLSIEDMVKVALEKTPPELAKDIVDRGIVLSGGVALMRGFAERLSRTINTPVIVAEEPLFSVALGVGKILDNLGTMRRVLMSVERGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9D5</accession>
    <name>D4M9D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease, Rne/Rng family</fullName>
            <ecNumber evidence="7">3.1.26.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_14170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14170"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.648"/>
    <dbReference type="HOGENOM" id="CLU_003468_5_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-891-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1" evidence="6">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="503" mass="57285" checksum="4D344E2153C5AF07" modified="2010-05-18" version="1">MSSLDCVERKIIADTREDEETRVAILEGGRLADVFIERMWDRQKAGEIYKARVESVLPGINAAFVTIGEGRNAFLYLNDVHGMKVVENQEIVVQVTKTAIKNKGARVTPRISLPGRYLVLVPDGGEAGVSRRIVDEEERRRLRHFARELKGDDFGVIIRTAAEGVDEETLAADVESLLALWREIEHDAELQAAPCLLYKDRGLLGRVLRDEVHGSVDEIILDSAEEMRHVNEYVATLYKTDRPQVSLYEGAVPIFEYYGVEAEIEQALERKVWLRSGAYLVIEHTEALTVIDVNTGKYVGDLDMRHTTLATNLEAADEVARQLRLRSIGGIVVVDFIDMEFEEDRKKLLDRLEEVFQLDRSRARVFSMTQLGLVELTRKRGRPDLRSVMTRGCPFCNDNGWVLREDTLALSIKRFLRKIAQTNRAEALLLQANSMVAQYVRDTYLAMWERELDVKILVAGMPDFAWSKYRIELQGTLSAVEHRAHQLERREESSIVVHRVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E2</accession>
    <name>D4M9E2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_14370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.677"/>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-898-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="187"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="423" mass="46194" checksum="494820322F99C8DC" modified="2010-05-18" version="1">MAERRKAENVLLDTALQEFYGAADEMGLSEKLISILSHAERRLEVSVPTEMDDGSVKVFKGYRVQHSTALGPAKGGLRYDPAVDIDECEALSMLMTWKCSLAGIPYGGGKGGICCDPLEMSKKEKERMTRTFAARIAPIIGSWTDVPAPDMNTGGPEMVWILDTISKMHGQLEPGILTGKPISYWGSKGRNEATGRGVATCGLEFMKALGKDPAKMTASIQGFGNVGSYTAKTLQENGVKVVGISDITGSYYSEKGIDIEKAFEVKDKDPKKLLNGFEKVGNCEKVDEVLFTKCDFLFPCARDGVINKDTAGKVLAKYVVEGANGPTTPEGDKIMADAGVKLVPDFLANSGGVIGSYFEWAQNLQGFFWTADEYNTRLIHIMKDNFKRVWDYAEAKKVTMRRAATMAAIQRVADVVELRGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9F6</accession>
    <name>D4M9F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_14660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14660"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.705"/>
    <dbReference type="HOGENOM" id="CLU_448274_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-912-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="623" mass="69498" checksum="436E673AD2C60B76" modified="2010-05-18" version="1">MRFDEDAAGTRSHPCGGVGTRLCRLLVAWLLLTAALALPAAAQGGEEVPEYSVARMRQLNPDFTTYPDAQGIVWLRREVFRRGDKGGMERTHLWVILGRRDLDDRWLTWRIPDPAGGRAEVLQACVYSFDTGEKLRDVAPVAEGGLQTVSFRDLPEPFVLAVAWRDVTPDALAFEDLVWLQEALPVWESNVEVHLPPSQSIVFRAFPQELEPEVRRAPQGSVYSWRVINTAPFEPKGLIRSRRSGLAFSMRRERAGLIRLMRSAVGTELPTAPDAARAGFHSSAEEGVKSLLNWLFLQPELHLPDGARREVPGAAPWTRNEKLLLARAWLAQEGVDAPMSWRLPIEPAEEPPLSPELLQDALLEVPAFHGKQRTRDSVFYDMSAPFDGGPSALLQGERVFGLSANGTLSSKEVPASRAAANRLFAAMELKMDEQGRLTGVVRLLLRGAWIPFLLRERSPAEAEVRAALLELFPDLRHYEDVQCRRSREGLELSFALKKKPGVASIGGPGLLAMPPAFLPKAFSALKGQSTPIELRFPFVLEQRWTIGLPRSAERILDEGETKRTPDRVNYSDSCKAWRHRVVGSARCEVDTLRVAEGDLALLQRCVALWQAFAERHIPVQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I3</accession>
    <name>D4M9I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PQQ enzyme repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15080"/>
    <dbReference type="HOGENOM" id="CLU_027480_4_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-940-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061553" evidence="1">
        <location>
            <begin position="26"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="353" mass="35940" checksum="8BD592AF51C54711" modified="2010-05-18" version="1">MRVNRILFAAALAFLAALPAGPAAAWRGEVGWTFRADDGISSGVAVAGNLVIAGDRLGKLYAVQKASGVPAWVYTGTNTVVGTPSVMGDKVIFAQGNGAVTCLALSTGAVVWQYLPPEEGYAAETLADGTAVGDGKVYLAKGDGKLYAISASNGRLVWTHTADQELRNAPAFEAGLVLLGEQNGRFSAIDPKTGKRIWGGGAGGAINTPVMSGGSVFYSSWDGTVQRVRVKGVIPLWKDSKPNVGEPVTTPPTVGGGRVFVGTANGKIVALSEENGAILWQFETNGGNVAARPVLAEGLVFAGGGDGVLHVLDASSGAERATLTTGEGINGTPAFDGGVLYLGSGDGTLCAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9I4</accession>
    <name>D4M9I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.767"/>
    <dbReference type="HOGENOM" id="CLU_057069_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-941-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="358" mass="38708" checksum="07A59A348F926E00" modified="2010-05-18" version="1">MSKDIEKIEKLLGDEAKDLLEHKCKAIPADMLHLPGPDFVDEVVAPSDRPNRVLNSLTTLFNHGRLAGTGYLSILPVDQGVEHSGGASFAPNPIYFDPENIIKLAMEAGCNAVASTLGVLGAVSRRYAHRIPFLLKLNHNELLSYPNKADQILFASVEQACELGAVAVGATIYYGSDESTRQIQEIAKAFHHAHQLGMATVPWCYLRNSAFKVKVDGKTTDYHVSADLTGQANHLGVTIEADIVKQKQAENNGGYTALNFGKTSKFVYDKLTTDNPIDLTRYQVLNCYAGRAGLINSGGASGGESDLAQAVRTAVVNKRAGGMGLILGRKAFQRPMKEGVEIIHAVQDVYLCKDVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K4</accession>
    <name>D4M9K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15390"/>
    <dbReference type="HOGENOM" id="CLU_1624724_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-961-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061759" evidence="1">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="163" mass="18412" checksum="B5575EF83359AD5C" modified="2010-05-18" version="1">MKATMKMVCKTICLAMAALLLTATAAMASPLVGGGDKGGDEAMERELDGGIHVTFLGAFRRDNRIFFDFIVEPQQDSILEVSQGLIFDNKGNKFKRSYDDSPYIGNENTYKREIIGDVKTRVRFRYSVDASYGNPFLTRMTFEFNGKELVFRNVQVQDEPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L8</accession>
    <name>D4M9L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent aldehyde dehydrogenases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15720"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.842"/>
    <dbReference type="HOGENOM" id="CLU_028794_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-975-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012408">
        <property type="entry name" value="Acetald_propionald_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036410">
        <property type="entry name" value="EutE_PduP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="25"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="457" mass="49162" checksum="F6C0FC13F5C661C0" modified="2010-05-18" version="1">MDTRQMEKIVRDVILRMQEERGEGNGSEVAVLTERARAAQAIWHGDFNIAAKTAVITRLRQDLRPHVEELAKMACEETGMGRFEDKVLKKRVAIEKTPGPEFFTTHAVSGDNGLVLEELAPFGVIASICPSTNPVASVINNTICMIAGGNAVVFAPHPGAAKCTHRTVEIVMKSLRESGAPDGLISSLQHVSLDAMNELMTSPNVNLISATGGPGVVRAALQSGKPAIGAGPGNPPVVVDETADVEQAAIDIITGASFDNNLQCIAEKEIIAVNCIADDLRAAMLRNGAFELKDPAKVDELLKMTLEKGKPSRKWVGRPASLLLEQLGYKVEPKTRIILVETGEDHPFAQEEMLMPILPLIRAADFEEALAMAKRLEHGFRHSACIHSSNVNHMSRMAREMQTTVFVKNAPTLAAIGVGGDCPTAFTIATATGEGPTTPASFCRTRRCVLHGAFRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M9</accession>
    <name>D4M9M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15870"/>
    <dbReference type="HOGENOM" id="CLU_705473_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-986-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="391" mass="42058" checksum="771D58162DF1C931" modified="2010-05-18" version="1">MAKFGGMTLTKEGRNLLAKALTGKDLKFVRVAAGDGRLPGGQSIYDMTAMAHPVQDLPIASCTVTGVGTATIQAVMTNQGLAMGFFVREIGLFATDPDSGAETLYGYCNAGNEADYMPGQNGPDAVQYLFSLVTVIDQAQSVTAVISSDLVFVTHPELNARIDELFTASAPIFEFWTRAQGDDKKLRPASLDKVKLSILGTHDIENLDGRIRVLEDVVAQTLLELEVSNIYPNYTHFIIEDFRKPDQADMFSCKVVHVVAGSSAIDCERIQGLVPGCTYTLTDGASRELVQVRSVNVENGLNRIVTSEPVKNTYRGGKTLLYRTSAIIMPDSAEGVSAPMIAAWRPMETWKGVTGNTVFDVVAPTNLASAGAFELEGDISWSGSTVTLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N6</accession>
    <name>D4M9N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Soluble lytic murein transglycosylase and related regulatory proteins (Some contain LysM/invasin domains)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15950"/>
    <dbReference type="HOGENOM" id="CLU_1330331_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-993-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="206" mass="22681" checksum="CA7946BB2BFDC942" modified="2010-05-18" version="1">MNWLLENAALLSLIVSTARGAQVPPEVALGIIKIESGGDRYAAKINPTYPYMMMQAKRPAGCSVDVERLFQKTAWGLMQVMGATARELGFDGWLSELVVPETNVRLGIEFLGRKMSQHLERDGIEGVVAAYNGGAPRRRPDGKFVNQTYVDRVMEAAKRFEAVVSKFETLETQPAAKVERKKKRGGQLEEAAPSEEAETRDPVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P0</accession>
    <name>D4M9P0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_S78_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.869"/>
    <dbReference type="HOGENOM" id="CLU_072269_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-997-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027924">
        <property type="entry name" value="XkdF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14550">
        <property type="entry name" value="Peptidase_S78_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S78_2" evidence="2">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="268" mass="28371" checksum="6927DE2B19FC4126" modified="2010-05-18" version="1">MPVELRDMKVDFISLVSKGANGKRIIWKAGDERPEGADAFETPLRKLVKSDEKRVVYGIVYGPGQVDSQGEYAEKGEIEKAAYGFMKGLRLLNVDAQHDFDPKAAFVAESWITKGADPLFPDEPEGSWAVGIRVEDEALWASVKKGELAGLSMAGYAAKVRKGEDGVLAKMEQFFTSLLKAVEGAEAKNAQPGQPAETKPGAGAPAGEAAAEAEAVAKIAKALEGIPALTESIAKLDERIKALETATPGQMSKGVDGNGADDGSYGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P6</accession>
    <name>D4M9P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized ATPase, putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_16100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16100"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.880"/>
    <dbReference type="HOGENOM" id="CLU_846889_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1003-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="91"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="303" mass="32868" checksum="1E6DE472035C2ED9" modified="2010-05-18" version="1">MQSNEINQLQEVIQALGLSNADVARISGKSTGTVSQALGGKYKGRPEVIGEIEASLVAYRKAQRERQEVREAWFTDGQKLIQSMLGLTYATRGFSVVVGPSGIGKTYTALNFKEGYSDVLYLRCADGMCMGDVIDALLELTGTPCYGSNSQRLRRAIRALLEGGVRMLLVDEADLLVTDGSRPKILKKISVFREVKEAGIGVSLIGLESFDTALRTVGETYVTSRIDMFRRASAPSARELGHYMANLGVDPETEGARRALSLAPKNGSMRFVEKAAHIARQLGDNMVEALRFLFAASGHVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S2</accession>
    <name>D4M9S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_16470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16470"/>
    <dbReference type="HOGENOM" id="CLU_1183647_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1029-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="234" mass="26470" checksum="36B7EF8FD3001C03" modified="2010-05-18" version="1">MLKTDQALLEDIMEQCRWIIRYSELADAQSPGERSRIVNSGFNAGDIFDMLHFNAVVMNIQQIGELAKRLSPEFVLRTKNEVSWSDIRGMRNIIAHDYGKLSEKTVREIEIIDIPKLAAFCEKELAATQAQDDAIPVVEAEARKLVGEDGQIFRPNPKGDHCYRGEVLKVTDTHAIQRSSAHAVYLHDLRDFPGDRKPSVGDVLAIRYSNARIEFVEPIPDKTQAKARQQDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U7</accession>
    <name>D4M9U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferases involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_17080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.972"/>
    <dbReference type="HOGENOM" id="CLU_033536_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1053-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="309" mass="34899" checksum="6F2A6523495695B1" modified="2010-05-18" version="1">MISLLCPCYNEEAVLPLFFERITSVMEGIGQDFEIVCVNDGSRDGTLDLLREQAEADERVKVVDLSRNFGKEAALTAALDHSTGDAVVPIDADLQDPPELIGVMLEKWREGYEVVLAHRSNRSSDSWLKRVTARMFYKVHNRISQPELPENVGDFRLMDRRVVDALGGLRETHRFMKGLFAWVGFKTCIVDYVRKPRAAGKTKFNGWRLWKLAVEGITSFSTFPLTVWFYLGSLTAFGAFAYGLYIVLRTLIWGIEVPGYASLLCLILFFGGLQLLGIGILGEYLGRAYMESKKRPVYVVREVYCRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X3</accession>
    <name>D4M9X3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_17550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17550"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1019"/>
    <dbReference type="HOGENOM" id="CLU_026228_5_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1081-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027150300" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="44"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="289" mass="30249" checksum="90155B3AD2349B98" modified="2010-05-18" version="1">MTKIRKGTKTMLKTFGRVFALCALLLAAAVAEAEPLDAFKDLEGTLDIAGGTAHIPVMTQAAQDIMTFNPKIRITVAGGGSGVGVKQVGEGLAGIGNTGRPLKEKEVEQYGLKSHPFAIDGVALAVHPDNPVKSLTGEQVAKIYTGEIKDWKDLGGEPGAIDVYGREDGSGTRETFTDKLLGKAELAPTVNVVSSNGAMKTAIAQDPRAIGYVGIGHLDQTIAGVAIDGHVPSQENAASGEYPVVRQLFMNTRGEPSGLTAAFIDYIYSDAGAKIIEKSGYIPIPRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X4</accession>
    <name>D4M9X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter membrane protein 2, PhoT family (TC 3.A.1.7.1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_17570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1021"/>
    <dbReference type="HOGENOM" id="CLU_033621_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1082-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="302" mass="31316" checksum="B8BD0FB3DC94706D" modified="2010-05-18" version="1">MRARFLREKLLLALGWTAMLGTLLSLSGLVLFLLVRGLPAVNLRLFFGSTPPLDAILAVRPVWGGIWPAAAGTLFLLAVTMSLALAPGLACGVYLACFAGRRERDWIGGCVDVLAGVPSIVMGLFGLQLIILLRRTFLPQGTTCLLLAAFCLAVLVLPVLVTSVRAALEALPQGLTLTASALGMTRGQAVLRLLLPAAAPGILGGVILAMGRAMEDTAVIMLTGAVANAGLPAGLTSKFEALPFKVYYTAAQYSGPEELSQGFGTASVLLLLSAALILGARALQGRLTQRWRGAAGRGGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X8</accession>
    <name>D4M9X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase beta subunit</fullName>
            <ecNumber evidence="6">4.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_17640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.3.6" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17640"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1029"/>
    <dbReference type="HOGENOM" id="CLU_044864_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1086-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008815">
        <property type="term" value="F:citrate (pro-3S)-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="14"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="303" mass="33291" checksum="A6943945C4B7A735" modified="2010-05-18" version="1">MIPRPKPERFRLRRTMLFMNAQRPGLIKDAYVYGADSIMLDLEDAVAENQKDSARFSLYHALKEVDYGDTEVIVRINGLDTPHWREDVRVCVAGGADGLRIAKTESAQDVRAVEEATLAAEREFGVEEGRTLLMAAIESPKGVLNAYEICTASPRLFGVAISGGDYRKCMQVKVVPGGIEMLAARGHLLIAARAAGVQCFDTVFTNLDDDEGFRAEVQQNKDMGFDGKSLINPRQISIVHEMLAPTQREIADAEKIVRAFRENADKGVGVFTINGKMVDVAFVPGAERVIRLAKASGVYEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y4</accession>
    <name>D4M9Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_17720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17720"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1041"/>
    <dbReference type="HOGENOM" id="CLU_133784_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1092-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="11"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="169" mass="19193" checksum="950D6712F6123EFD" modified="2010-05-18" version="1">MVFSEEARIGGTLVWYWSICVRQVWLMARGIEPEPRDDFLALGRLIDRNSYARERHQVAFGDNRFDFVQGADGDLVVCEVKKSSRAERSARLQLAHYLYDLQKAGIEARGVLMFPTEKKRVEVVLTDELMAELDAAYDAIGTLVRRDAPPAAESCKYCGKCAYAEYCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA02</accession>
    <name>D4MA02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_18110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18110"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1075"/>
    <dbReference type="HOGENOM" id="CLU_1250139_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1110-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="203" mass="22868" checksum="8F974DE7E47ECDF1" modified="2010-05-18" version="1">MDPKKNDSGRDMTVNDLISAISMTEYPQYILDALSRIQGWMRDTINAPANRGIDPFSALFEGEEEDDEGPGVDTLFESLEELEEYVDLIPNTHRPDGRADVIVVSLTPPPDYESGLRTAIDYAALFNRPNCKRVWIVSDTFIFDDVVRYAAHVDALTEQGVTLRFILVTPWGWVELPLSGAAASRQQFTWRSQLKDGTGKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA03</accession>
    <name>D4MA03_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="10" type="ORF">SY1_18310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18310"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1093"/>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="9">
        <location>
            <begin position="711"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="517"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="333"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="784" mass="85857" checksum="8E1EAA42FD29C5EE" modified="2010-05-18" version="1">MRADPSVLELLEFRKALSPLRERLGGELGALALDRLAPAEDFAHLSRRADLLKEWQDLLDAQGAPQWSADLPAVTPLFEGARRSGILSGGELLMVRALMGAAKRVRDGLADAPNPALEALRRRLRDFAPEIEALSVVEDTGRLADRASPKLAQIREALESLKRSGRRTAERLLNDPNVLNMLQERTLAWRDGRFLLLVRQEYVNRFPGLAVERSSSGNSVYMEPRMLSSINNGLLMRTHEERDEEQLILLDLTRKVLARAGALDAAERVLGELDLMTACDGLVRGRGWIVPALSRKRGLRLVGARHPMLKDAAVPVDVSCGEDEGFSTLVVTGPNTGGKTVVLKTVGVLLLMAWCGLPVPARDGTRIGSFDAVFADIGDEQSIEQNLSTFSAHLRKIVGILRDATRQSVVLLDELGAGTDPQEGAALGTAILETLRGRGCTTLATTHHNPIKQYALTTPGVETASMEFDAERLAPTYRLLMGVPGKSNALAIARRYGMPEEVLNRAQGELAARGVSAEELMGELVERRAALDQAERSFQETVRETERLRQAYQDRVREIDGQRDSIMEAADRRAEQLLSRAEAASKGMIRDLEETVKMRASQGLEGRRQEIRRIRSGIDRRRDRRVEREIASRPASFSVEPGVTVQVAGSGIVGVVESVKNGRAALMAGPMRVEVPLEQLAPTEKKARVAVPPPNAEAMSRAETVPSSIMVRGMDVGTAMPLVEGYLDRAYRANHTSVTVIHGRGEGILRREVHALCSRLKYVKDFRLGGEGEGGFGVTVVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA29</accession>
    <name>D4MA29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ade</name>
        <name evidence="9" type="ORF">SY1_18740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18740"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1135"/>
    <dbReference type="HOGENOM" id="CLU_027935_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01295">
        <property type="entry name" value="AdeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="62"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="8">
        <location>
            <begin position="395"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="587" mass="62535" checksum="C5D00520F968CC54" modified="2010-05-18" version="1">MNTLAAVARGSRPADLVIRGARVANVFTLEYEEADVAVCGDRIAGVGRGYEGHRVLDAAGAVLVPGLIDGHVHIESSLMAPAAFADAVVVHGTTTVMADPHEIANALGLPGVRYMYLASRGLAVDVFLGAPSCVPASRLETPRDELDMMAVREMLREGWCTHLGELMNYPALIEGDPDVWGRVAAAGDVVLTGHAPGVSGKDLNAYLTSGVSSDHECVDLDEAREKLRRGMWVMMREGASFPNLRTLLPLVKENPFLAARCMVVTDDATARYIRDTGHMDAKLRIMIEEGVDPLVALRLTTLSPADYFHLWDRGAIAPGRRADLVLVDDLASFNVKHVWKDGRAVVQDGVAVKGAQARSIPLPHAVQTMPLTEEQLRVPAGGETMNVIEMQPGEIITGSRRMPPLVSEGNAVPDPSRDLAKIVVLERHHGTGRFAVGFVTGFGMQRGAIASSVAHDAHNFVTVGMDDRSIATALKCLCETGGGLVLAEGGSVRGSLPLPIGGLMTHLDAESVARALEDLERGAEQLGVQLPHPFMALSFLCLSVVPNLRITDQGYVDIMRGGVQPLFPEGGRAPQQGDATAVPNSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA45</accession>
    <name>D4MA45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19000"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1161"/>
    <dbReference type="HOGENOM" id="CLU_2316196_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1153-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="99" mass="10644" checksum="144939234DB0AAC8" modified="2010-05-18" version="1">MTVQTNNFYLGIDLGTTNSVLAWGRVDARSGRVIPMVAELRSMSAGQGMVKQALLPSCVYYKRGSEQPIVGGYARTMIGRQSSRVIKSVKSAMGSGKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA55</accession>
    <name>D4MA55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-54 interaction domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19120"/>
    <dbReference type="HOGENOM" id="CLU_643646_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1163-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="205"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="426" mass="48295" checksum="3D98CB12C5597E06" modified="2010-05-18" version="1">MTNKKLTERSIGIYLHFDRKKTEYKECMEILKKAFESLSTSGKEELREPGYDFVPNIESAFFVIASPKTLKNCKPLDKGPMPTILLLQDDEWNDDTADVLADPQWDVRGLFRLSRLGEKWDYEEFGDLASAVKELARESMRQGGGAEESFRKPVDWKAKLTAQHRVGFVSLFSDPSTRTMARQFKNALGDIGKRLPLTPNTRPPSLLLLGETGCGKSLLARAAADVLFPGAENRFKRLNISAYTNDLIDIELFGSKKGAYTGCDEDRPGVFVAAQGGVVFLDEIGDMEPRNQTRLLTYMDDGNVLPRGTTEKVSAPCVVIAATNRRIDRGEGDFREDLFCRFDHVITIPPLRERKRDLRLLVSLTLQDEEVNPDRKVRFISLDAIEYIERRNFPGNFRELRFLLRQSVRRAVASASECLCLRHFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA64</accession>
    <name>D4MA64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1191"/>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1173-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="460" mass="50304" checksum="E6AA55A2EE29A6D8" modified="2010-05-18" version="1">MAERAGKSKKSNQIDMLHGSLWDKIVLFALPLAASTILQQMFNSADVAVVGRFDSSQAMAAVGSNGAVINVLVNLFVGVSVGANMLIANYIGQGEREKVRQAVHTSVLIALISGLFLAVAGLVLSRPVLRMLSTPPDVLELAVTYLEIYFMGMPFIMLYNFGSAVLRSKGDSRRPFWFLVVGGVVNVILNLVLVIAFRMGVTGVAIATVISNVISAWMVLSCLMREPDPFAFSWREMSLKGGHTRRILKIGVPVGLQGVVFSLSNVFIQAGINSFGASASAGSAAALNFEYFAYFIISAFAQASMTFTSQNYGAGDEGRCRRIYTISMSWGIGLTALTCAAFSFWSEPLMRFYTVDAAVMTFAMARLFRAAVLEFLVGFYEIPGAALRGLGYSMTPTVITLMGSCVFRIFWLLTVFQWNRSFEMLMNVYAVSWVLMSVATIVAYYRLRPRAFSRRALGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA4</accession>
    <name>D4MAA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_19930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19930"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1253"/>
    <dbReference type="HOGENOM" id="CLU_018808_15_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1213-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="443" mass="45200" checksum="4AC51832675B0198" modified="2010-05-18" version="1">MEFQMGLGIVLVLALIVGVGLWSGRRVKSKADFLTGGGQAGPALVCGALMGSLVSAQSTIGSAQMAFYYGLTAWWFTLGSGLGCLLMALGYVRALRASGCVTELQVISKEYGGAAESVGAVLSALGIFITVLSQIIACIGLFTILFPNLSIAWAAVLTVAVMGCYVVFGGAWGAGMGGVVKVALLYLAFMAGIVLVLRCEGGLPGLAETLSNLLAGTPLGMVQRAAANVPNVADGGDLAQRFASLTARGLPTDMGSCLSLIVGVLSTQTYAQAVWSAKTDAAARRGVLISALLIPILGAAGILMGLSVRAHYITQAEAEALAAAGQAIPDLPVLASTLHVLPAFAMDHMPPLMAGAVLGTLLITVIGGGAGLSLGMATILVEDLYRRATKRIDTASKELLATRLTIVGILAVGAALAVLAHDSKLNDLGFLSMGLRGRWCSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB8</accession>
    <name>D4MAB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20300"/>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1226-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047980">
        <property type="term" value="F:hippurate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="198"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="404" mass="43454" checksum="5514E7181DA42B26" modified="2010-05-18" version="1">MEEHERIEREVRRHLDRVVEWRRAIHRHPELSRCEERTAELVAGVLEGLGLEVRRGVGGHGVLGLLRGTGGGADMGPTVGLRADMDALPMQEETGLPCASEVPGVMHACGHDTHTAMLLGTACVLAGMRDALPGNVKFIFQPAEELNPVGGAPGMIADGALEDPRVDGLFGLHVWPAYETGRVVLRSGPQMGASDRVYLTVKGRAAHGSAPDQGVDAIMIAGQVLCGLQSVVSRSVSPLDAAVVTIGTIKGGWRYNVIPDRVEMEGTVRTLREEVQAAMPDLIERAAEGIARSLRGSCEVRYVKGYPPLVNDPEMFDLAAEAVREAMGAEHLVVAERPELGAEDFAFFARERPSAFAWLGCRPAGVGPEETGVLHSTRFRPDEGCFPFGMRFLASCAVAFLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC0</accession>
    <name>D4MAC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20330"/>
    <dbReference type="HOGENOM" id="CLU_1494145_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1228-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="180" mass="19854" checksum="46C4E85FC7E25B1A" modified="2010-05-18" version="1">MMAGIALETALRAFASRDGHETEGGIVMRKVFAAACVLAVLLAVPAAADPWTKYENDRFGYSVEYPDIFSEMKEPENGDGVWLSSKDGRYALTLSGGYNVLEEDGEAMLASRLEDVSHVLSKEAAPDGYRLVYGDGKERLFFECAVVNEEAWTSFVLSCPKEEQERFASVAERMEKSLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC6</accession>
    <name>D4MAC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20460"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1308"/>
    <dbReference type="HOGENOM" id="CLU_1178830_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1234-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="235" mass="26241" checksum="4C6A476BA0164048" modified="2010-05-18" version="1">MNDDKSRKGVTVRYLVDANHWISHVVAETDGTGVPLAYYTRNGGRLPKAAASSMILSRATTRPPALMTAHDRRLRDMDKKMDMRRRDRQLSEEETLEVLQHGEYGVLSTVCPDGTPYGVPLNFALEDGRIYLHGANAEGQKIVNLRHCPDACFTVVSSTKLLPKEFSTLYRSAIVCGRVSTVEDDAEKRRGLEALLRKYSPEFIESGLKYIEAAFKAVRVLRLDVASLSGKGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAL6</accession>
    <name>D4MAL6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">SY1_22020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22020"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1455"/>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_0"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="256" mass="27091" checksum="CE8AB3C9A575A326" modified="2010-05-18" version="1">MLLVMDVGNTTTVVGVFDRKQLVAHWRLSSILHTSDELGVYILTLLGTKDIASTRIDGAVFCSVVPTLDAPLAEAMRNFFGVEPLRVDASTDTGMEVRYDAPREVGADRIVNAVGGRSKYGAPLIVADYGTAITFDVIAPDGAYLGGAIAPGLQSGISALFAKAAKLPQVALALPRSVIGRNTNESIQSGILFGNAGLTDRIVGMIRAEIGTEVKVAATGGHAEVMAKLSQTIEYVDPWLTLDGLRLIHDRVRGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN2</accession>
    <name>D4MAN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22270"/>
    <dbReference type="HOGENOM" id="CLU_2649230_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1341-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="76" mass="8811" checksum="C6840633AD993AA0" modified="2010-05-18" version="1">MTLAQVAEREALYRLIDQLPDRQTPLVVDFVRRLLDVDDEPLTPDELRQLETSNAQIDANEFCTLEEAERRLMALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN6</accession>
    <name>D4MAN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_22330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22330"/>
    <dbReference type="HOGENOM" id="CLU_2751979_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1345-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="70" mass="8043" checksum="F9D7215105B3C53A" modified="2010-05-18" version="1">MPLSLTQIQRAAVRMLEELSEDSLASAVDYIAFLRSIEEREDEEDIACYLERREETTIPLAEVREKLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAN8</accession>
    <name>D4MAN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D</fullName>
            <ecNumber evidence="8">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_22370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1482"/>
    <dbReference type="HOGENOM" id="CLU_019134_2_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1349-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asparaginase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="7">
        <location>
            <begin position="223"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="2">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="350" mass="38141" checksum="3659F501456422AF" modified="2010-05-18" version="1">MMIFWRLTMKFTLFTTGGTIASAPSEDGLRPKLSGRELVNLCPALEGFEHDIRVVDLMSKDSSNMQPDDWFAMVQHIRQSASDCDAVILLHGTDTMAWTASALSYLLPDVPIPVVLTGSMLAPEARDSDAADNLYTAVQMSMQLALYRRQGVAVVFDDVLIHGPRAAKADSRRRHAFVSVDYPLLGEMRDRGQYKIPWLSSKRPKLSPSRPWGGSPLPALERNVAILPIFPGMPVRLLDAILDARPAALVLEGFGLGGVPFTGENLLPSIDRGIRAGVPIVVRTQALFGGTDLGVYEVGEKVMDLGAIGARDMTREALVVKLMLLLPLAAGPRELERLLGQNLCDDVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ9</accession>
    <name>D4MAQ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="7" type="ORF">SY1_22700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22700"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1514"/>
    <dbReference type="HOGENOM" id="CLU_148710_2_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="92" mass="10704" checksum="3D857BBB43466BF7" modified="2010-05-18" version="1">MNGERESRPAGAAAPRGGMRRGSKRRPKFCYYCVEKQEKVDYKDVEKLRKYISERGKIVPRRVTGNCAKHQRLLTEAIKRARYMALLPYSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU4</accession>
    <name>D4MAU4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">SY1_23300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23300"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1571"/>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="544" mass="57708" checksum="A4B6A864B2DFE94A" modified="2010-05-18" version="1">MAKILSFGEDARRAMLRGIDKVADTVGVTLGPKGRNVVLEKKFGSPTITNDGVTIAKEIELEDPFENAGAQLLKEVASKTNDVAGDGTTTATIFSRAIIREGMKNVAAGANGMQMRQGIEKAIDFVVEELKKQSIPVKEKEKIAQVASISASDNAVGSLISEAMNKVGQDGVITIEDSQTVGTTLEMVEGLQFDKGYISPYMVTDSERMETSFDDAYILIHDGKISNIKDLLPVLEKVVQTGKPLLIVAEDVEGEALATLVVNKLRGVMQVAAVKAPGFGDRRKAMLADIAIVTGGQVVSEELGLKFENTELSMLGKAKKVRITKEDTTITQGAGDKEEIRKRAAQIKKEIEDSTSDYDKEKLHERLAKLVGGVAVIQVGSATETEQKELKHRIEDALNATRAAVEEGIVAGGGVAALNCATALEPFVEKLAGDVRTGARIVLDALKAPLFLIAENAGYQGDVIVEKVRNLKPGNGLNASTGEYVDMVAAGIIDPVKVTRSALQNAGSIAAMVLTTEGIVADKPEKKDAAPAMPGGMGGMGDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV2</accession>
    <name>D4MAV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_23400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23400"/>
    <dbReference type="HOGENOM" id="CLU_097479_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1413-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="194" mass="22412" checksum="2A0AC05182868159" modified="2010-05-18" version="1">MKELGVVMRLRELGVTGTMLNTGRHPMGLSLSAMRKVLEDENICDSLKGRVQYFVTRYRESHDQEGRVAVRLDGNEIFKSNFYDGEIKRHEAWSEIDASKGRHTEYSECGEQIELEALNKGGFDRFAFYNAFHSYQNSGIDDSLQSPDPVVRLFAILDKRVGKRRLHKIVSETEQQPAWLKPFYRLRLELDGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW2</accession>
    <name>D4MAW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich Repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_23530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1595"/>
    <dbReference type="HOGENOM" id="CLU_437277_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1423-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030821">
        <property type="entry name" value="Synergist_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04564">
        <property type="entry name" value="Synergist_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="625" mass="66608" checksum="B88E5FACAC9856D1" modified="2010-05-18" version="1">MIVKPEFGAKNLKGIEYFTYLETLVCSNLELTSLDLSGNKKLTSLHCTNNLLTSLDLSENTELKTLHCENNNALTSLNVSRNTKLETLNCTNNPLTTLDVSRNTALTDLACSGTALTSLDVSQNTALTELACASNALTTLDVSKNTALRELKCANDQLTELNVRANTNLLKLDCSDNQLTALDVSKNTELSTLNCTNNRLTALDVSKNTELSTLNCTNNRLTALDVKANTRLDALYCQGNRLTFLDLEGLPLTSSATVGAQTRDDLILQQRGDKYEANLGTFIPREGFIKVTRLAGLSGGMSIPAVYDSTSGKATFDAEPEKVTYRYVTSNDKAPLMDVTLIVGNVITVSVSGRGRVTHQGSTEALSGDVVVSKGKDATFVVSADAGYAIASLRVDDAPVSVPLVATRYEYTFRNVTENHTLRVAFKARPGGSPGWPGGSPSNPGGSPDKPDVPPTSPDVPPVNPPASVDIPASAGQWTVFWGTPDAQGKVEVTVQVPIKSEVPLIEGSIRIDALGIEGIRIKLLPDSPAASARAMAQQHSYLLQITGTVAENAMNTARIDALHYRLEGGEEKMVRLGTNGDGILLKDMKKGTEPPKSSSGGGCAAGLGSVALLALVPLYIRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW7</accession>
    <name>D4MAW7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="11" type="ORF">SY1_23620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1603"/>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="399"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1668"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="983"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1057"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1064"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1067"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL29012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1705" mass="188116" checksum="DEF0C5FF4D70BC20" modified="2010-05-18" version="1">MARKEIVGVRIKLATPERIREISSGEVKKPETINYRTLRPEKDGLFCERIFGPTRSYECTCGKYKRSGPKFRGVICDRCGVEVTDNRVRRERMGHIELAVPVVHIWYLRGIPSRLSLLLGTSAKDLEKVVYFAPTRKTENAWKVTAVGSRPDLVHKDSVISESELKVHSHYDPKFRAEEAFSLESVDDVPVDEGDVLSAQQVARFKADYGDDTFKVEPAFELIEAIEGLDLNVGEIVPASRMEECSAEAEAPFVRAKVAGSDAFIVTAALKLPFSRGSILSKSEKDMFEQRYPRRFNAVRLGVTVDDPCYLVVESGNSPFSQADVIYERQELLCAEYDKKFEAGIGADGVQTLVNRLDLDLLTASLREEIAESSGQKKRKLVKRLQVAEDFRKSASQPQSMILNVLPVIPPDLRPLVQLDGGRFATSDLNDLYRRVINRNNRLRKLQELHAPEIIIRNEKRMLQECVDALIDNGRIGKAVTGASNRPLKSLTDLLRGKKGRFRQNLLGKRVDYSGRSVIVIGPQLKIYQCGLPKQMALELFKPFVVRQLVDRGIAPNVKSAKRVIERGREEIWGILEEIIKDHPVMLNRAPTLHRLGIQAFEPVLMEGKAIRLHPMVCTAFNADFDGDQMAVHVPLSLEAQAEARLLMLSANNLLSPASGRPVVTPTQDIVLGVYYLTDMKPGMKGEGMHFSSIEDVLSAHDHGMVHINARIWLRKDPTWRRQPMGRHQYGGPDGEAIVVDRAEDVAAPEGASVFFETSPGRALFNSIIARDLCYVNYQLGKKKIGSLLDEAYDKIDRAGVVEMLDAIKALGYRWAAKSGISFGVKSIIIPPEKAEITKATQIEDDAAKDNYEMGLLTHDEYLDQKGELWARATKDIANKITEHMVPGNSVLMMVESGARGSLGQMGQMAGIRGLMSDPTGKTIDYPITANFREGMNMLEYFISTHGARKGLADTALRTAKSGYLTRRLVDVAQDLIITEHDCGTDKGICIRPLMSEGKVMIPISERIAGRTALDDIRAPETQEVLVRKGEIISYEKASAIDAAGLEEVWVRSPLACGLKRGICQKCYGLDLSSRYLIPIGEAVGVVAAQSIGEPGTQLTMRTFHTGGVRQAEDITQGLPRIEQLFEVRRPRKVSLLAGLDGVVEEIRNADGKRRVIVSTLDGSEKITHAIPSSQDLRDDIAEGKAVTRTTPLTEGSIDPQQLLDVSGISAVQRMLVDEIQYVYHSQGVSINNKHIEVILRKVAPLNRVRVLEEGDTSFVAGDMVWLDEVEAAEREIREDNERYVAEAVRIFSGDVLTGAEKMCEEVEPLLNKPLDEDALRTLLTPGMMLTSLTLSHEGRSIEVVIGEAAFRKQMEGLELVSDFQDGEEGLDRGTRLGKAELRTITARDPHVILVRNRDLLEKQAGTAWLAEDVVCDGQVLAPMDTQLTPEAAALAAEKNVERLRVWHNVDHINVTDTFRTALMEDDRVWGCNLLSASDADGKLIEKVPQFVDASVIQGLAQGEISALETDSEVQTREALFERFLAEKLRGKILLDASFAKDGAKAPEFGKELSAAKLKEFAAAGPTDIYVRSAAGKADEYPLIREVTFVRKLRESPECKPFIHGITKAALATDSFLSAASFQQTAQILAGAAVRGQIDPLHGLKENVIIGHLIPAGTGAEPFRGIASAAEAEEESAPVPIETGAEEASEAIPQEEGVSSAPFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX3</accession>
    <name>D4MAX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation/multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23770"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1615"/>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1435-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="951"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL29018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113433" checksum="164F2BC4AF435A04" modified="2010-05-18" version="1">MRSFVRFCIYHPVFTACSVVVWVLLGVSSYFTLGVTLYPDVELPFVLVRTTYDGAGPNEIEQLVTKRIEDELADVDNLKSLTSYSQDGVSMIAVEMESGTNQDLALLNVNNEVKAAIPDLPDGADEPVCMKFDISSQPFLTVAFAADSMPEKAAKKIIEDRIQPIVSRVEGVGQAYVSGGRDRQIQILLDPSALNEYGINYLQVCNVVAANNQTTPTGYVTQRQDEISLRLVGEFNDVEQLENILIPTSRGEPVRLSMLGQVVDAEVDQRSLARANGSPVVLLRVSPSSNADVVKAGAEIKRQLARLMRDYPAFTYEYTQDDTSYVESAVKNIVRDTGIGILLTALVIYLFLGRLSATFIVACSMPVAFAATFVPLQMYGYTLNLMSTLGLALSMGTLVMNAILIIQNIYRYRDMGCDPFKAAEDGTVEISVSVLAGVLTNLGVFMPVAMMNTISGQFLRPYAVTIVYATIFSLWVTMAVTPCMAARIRRQEGDAELPLMGRILTGWWNWLFDGFRDLFVLLLKGAMRFPASTVLLVLLMTWGSLKLGGFVGTQFMPESDDGTIRILVTLDNNASITRTRDVLEQVEAFIEGMEDRKWIRSVVSSVAGSMRSQALNEANVSLYLVNAEEGRPSTQEIADRIRPFLATLPGVEYSVSATRAGFSDPISIEVRGTDLNVLYSVAEEIRARGRKVPGVRDLAIGMELGKPELRVEPIRWRLSPLGLNIADLARIVRGYLIGMNSGKFRQDGYEYDIKARLSREKAGDIFKVHELPVMTGNGLVPLDEMANVVWGDAPTEIQRKDRVRIVPVTGRVRYITTGEGNARMKEITDAMTLPEGVTISFGGEAEDMAEEFAELIRTLVIAIVITYLVVAAILESWTYAAIILFTVPMAAIGVVPALIVTGVNISIFAIIGMIMLVGMVVNNAIVIVDYAEVLRGQGKHPYEAIEEACVVRFKSLVMAVVTSVVSLIPLLSTGRGAEMKLPIAVVAIGGLLAGGSLAMVFIPSAYKLTWRIRLFLGRHRGAGANWRRGTQRCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY2</accession>
    <name>D4MAY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_23930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GT8">
        <property type="family name" value="Glycosyltransferase Family 8"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23930"/>
    <dbReference type="HOGENOM" id="CLU_050833_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1444-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="345" mass="38649" checksum="A7B5539A0BC2F17A" modified="2010-05-18" version="1">MRGGATRTEGPIHAALALYDPRGTYSQHAGVVMASIFENTESPVVVHVLHDSTLTEEARGKFLRTAAKYAQEVRLIDVTPYRDQLDARTVALVQDACSVGTLYRLLIPDLLPVGRVVYLDCDTLVNLDLRELWEVSLDGNCLAGALDHPGRGLRRLSAEALRVRLNGGDPASYVNAGVLLMDLDRIRERGSLFQASMDWLAHRGHTARLADQDILNSLFRGSIKLLDDRFNNRRLEEDPSNSILHMINESKPWLGLTGLLSERLYWRAYLRSAWGENTTRDELIDLLSRTASHTPSLHRHTAQCWRRIGLRLRRDILCGEPVLAVGLLVREFLHRLAAGLRGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAY8</accession>
    <name>D4MAY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_24030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24030"/>
    <dbReference type="HOGENOM" id="CLU_2879345_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1450-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="63" mass="7168" checksum="84C1CF88EFF2852C" modified="2010-05-18" version="1">MKNNASWIFLIITLFSTHLSAESYWTPLERMENGYCVREHAVMVTTAASIPESAILILELKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ3</accession>
    <name>D4MAZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_24090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24090"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1653"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1455-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL29038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="308" mass="34006" checksum="2BFD2092023D6C5B" modified="2010-05-18" version="1">MGQYVLKRMICMVPVVLGVTLLVFLIMHLAPGNPAHLILGENASQEQIVQLEEQMGLNKPLTIQYFNYLTKLLRGDLGISYANGTSVTSEIMARFPYTLALTLVAAITSLILALPLGILAAVKQNTWVDNTSMIVSLIGISMPIFWLALMLILLFSLKLGWFPVYGANSWRSIVLPAISLGFMNMASISRTTRSSMVETLRQDYIRTAYAKGLSNRTIVMRHAFRNGMLPTITVIGLQIGEMLGGSVLTETVFAWPGVGRLMIQSISARDTPMVMGCIVLMTVCFSFVNLTVDLIYGAVDPRVRTMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ9</accession>
    <name>D4MAZ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="5 9">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SY1_24150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1657"/>
    <dbReference type="HOGENOM" id="CLU_009116_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1461-MON"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="12">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="11">
        <location>
            <begin position="132"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL29044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="405" mass="42711" checksum="2300F7AAB88BA451" modified="2010-05-18" version="1">MINVAILGFGTVGGGVAELLEANRDRVAQAAGDRVRVKHILVRRDLPGSRYAELMTRDVGTILNDPEVSVVCEAMGGLDPALPYVRSTLEHGKSVATSNKELIDAHGPELAAIARAHGLSLLFEGSVAGGIPILSTIRDACAHERFDSAVGILNGTCNYVLTRMEREGLSLEEALRQAQENGYAERNPDADVQGHDTARKLAILASLLSGTRVSSDQVPCEGIMGLEAADLRLARALRCSLKLLGVCRLAPTGLSLRTAPYLVPAASPLYGVSDVYNGVLLHGSTLGDLTLCGRGAGRFPTASAVVSDVVQCARNRGRTVECGLTGRDAKLADASAAEVRNLIRVAPSEASLAREVFAGAEEVALDGDPQDSAFVTRPMTERRCGEALAKLSTLRSRIRLLEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y2</accession>
    <name>D4M6Y2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="6" type="ORF">SY1_00240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00240"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1723"/>
    <dbReference type="HOGENOM" id="CLU_095424_4_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="95" mass="10395" checksum="FB1D2343CE4851C9" modified="2010-05-18" version="1">MIYKFDIQFFAHKKGQGSSTNGRDSNPKYRGVKVYAGTEVTAGSILVRQCGTHLHPGKHVGLGRDFTLFALVPGKVEYAVKGDRRYVSIVPALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y4</accession>
    <name>D4M6Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/H+-dicarboxylate symporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_00270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00270"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1726"/>
    <dbReference type="HOGENOM" id="CLU_035303_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-10-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="404" mass="42240" checksum="A2AF96867432E933" modified="2010-05-18" version="1">MGNEGQKKFHIGLLPRLIIAIVLGVVVGTMARSAELPLIIQIGATFNSIFGNFLGFCIPLIIIGFVVSGIAELGEGAGKTLGLTVLIAYASTLFAGLLAYFVDVSVFPSFLKVGSIVLEDAQNAEETMLKGLFSIDMPPLMGVMTALLLSFIFGIGIAVTHSTSLKNGFSEVQHIIEKLVAGVLIPLLPLHVYGIFANMTYAGTVMDIMSVFVRVFAIIILLHVAVILIQYTIAGTAAGKNPIKLIRRMLPAYFTAIGTQSSAATIPVTVACTKSNGVSDRIAEFVCPLCATIHLSGSTITLTSCSIALMMLNGMDVTLGGLFPFILMLGITMVAAPGVPGGAVMAALGILSSMLGFNDSMLNLMIALYIAQDSFGTACNVTGDGAIAVFMDVMTRGKQGQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Z0</accession>
    <name>D4M6Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellin and related hook-associated proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_00340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00340"/>
    <dbReference type="HOGENOM" id="CLU_259999_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-16-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="4">
        <location>
            <begin position="1238"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL27635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1319" mass="141752" checksum="84E8A0846C73D70A" modified="2010-05-18" version="1">MYSRATSVGSYKTLLSSLQGNYRNIQNLQKQLATLKKYSNLSENPSAISRALELQSAIGANEDYKENGENAVALLKHAEGVLDQVLNAAKAIRTLVIQAGDAALSKSDREIIAKQIEANRQTILDALNTKVAGQYLFGGTSTGEAPFVLNADGTLTYRGTDERIKYALSNVLTGDVSFTGSEVLPNKEKAYFVCSHYVPLDWQWKGREEKVQITVGNRTISVFIPERWIDEVATGKTKPTDYNQFRDPGEVSGISLDDLAALVNRSLEEQGADMLVRASVEKDLASGRQQMVIKSHTGEKVGITGWPTTDYTPMPQSIAGIQFKKTGTTAGGNLKVETPNWNASLLGGTADISLSGLKDKALTVVTTAKDGTQEKKTYTFAADPANVKALLDELNTAGVLPAGVTASSRNGKLVLTSADGKSIRVDGTAAEQLFGAARRSEAAKYSGLMGKASVLGWRDDSLGKGITVNVDGKDYDFEFAGMRSISDLVAEINKKIPVDAGDVPVASVVAGRLVLQSSRGQVTVKDHGAAGGVQQLFGEAGPVKSSTSSLSVKVGDKLSVTVYVNEGDTLTDVAEKLNAIEGVYSRTSADADQLVAVAKRVGELPADSLSTNAAAESLHYPSLTITGSGGALALFDFTFAEDAETGEQRGVIASKPQTRPVDHSHMDVFDVLGMETALKSVEFENGRTLKVGQLKDPTKPYDPKTNPYQGKPLHWRVMSGGHTADITLNPGEYTMDDLAARIRNAGAGWLDVTVDVYNKDGRSEDGTESGLGTSYNGEKATQRLVIRGLKGEQVLFLDMNDQHYADEMGLSTSLRTTPDMGVKSIVFPEAPCVDDELGVKVRVQMNCGKTYDVNITKKAVVDPATGEVDRVKVMREIVNQVNAQEGANVMGLTVPVDKNGAEIPHSASIHFLSGEPFSVVDLPFSDPEWSDYAGGIAAQLGIHGGVSANLKRTEAPMKDGQKFGASGVLRFESLGRSVTIDVSENDTVKDVMDRLRSQAKDWLYVNYFDAHLGQEGRQSGDYPILSIAAKDGSAVNVVDVKGTIAKKHLGLSTGIQGEKDVSGMEWSVGETEGSVFSITVAGYTHTIDMTAMRDVNGNGKMDAKDLVATINARMQDYDVKAELNDEGRLVLWSPRGYSIRAEVTKVKADGTPMTTAGDRTAEFFGGTASEVKTCYRGGYKLDDPANTRKPQGIFVQNTTNRSGANERKQNGYEMFGDVTAAVRAGNRTGLSEVMLPRIDAFIDNVLSVLSSNGAMQNRYKANMDRLTTENTLLTETHDELATVDPAEIATQLMMANYVYQSNLAVIAQLIQPSLLDFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M706</accession>
    <name>D4M706_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted multitransmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.172"/>
    <dbReference type="HOGENOM" id="CLU_028166_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-33-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="392" mass="41352" checksum="177BC161566143EA" modified="2010-05-18" version="1">MRRLLGRRGQVLGLTLLRLAVSLAAAAAVYWGTDYWTTRIWNCEESLIVRVLGMGPETPVPPARGEQESFPTLQRQLTLLILTGDQRGVTANVKVVRLDGSGLDPIEGRRYLLVQDVFEGGEVQYSIADAYRVPSLVAFVAGVCLCLLALTGAAGFWALAGLALSLVVLIWGMIPLMTRGWSPMAMAFAAILLVSSATIFCVVRRSCYRSAALLGSLSGAGCGFLLGAFMVWAWQLSGLAGEGAALLASTLPGIDMQGILLASILVSAIGAVLDVAVSVTASMAELVSYAPDIPLRRLWTAGISVGSEVLGSMINTLILAYLGSSLPMAILICSAGANLLGILNDPYIGQQIVQSLAGTVGLLCTIPTTAFFFVVQEGWNRRRSGATEARNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M721</accession>
    <name>D4M721_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00980"/>
    <dbReference type="HOGENOM" id="CLU_1394559_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-48-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="195" mass="21529" checksum="F38E04A6D71DF5A3" modified="2010-05-18" version="1">MSDAPERHGSTERTLRWFCGVPVLTNPLLLMDLASALVILWFVTVLVMALAQVVFGGGALAGTHLAAASIYASYLVLLVGVLFVVVCLLFYRRGYVMCYRFEDNGVFVETLRARNVPGASGAHVRPFAVGVPEGVVGSVARDVDWSDVRSLRELTGMNSFQLRGKYGRLAQIYCPDEKTYREALAFARRKVERHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M777</accession>
    <name>D4M777_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.824"/>
    <dbReference type="HOGENOM" id="CLU_013446_10_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-103-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="564" mass="62291" checksum="C0514CD5F75BE38A" modified="2010-05-18" version="1">MNSAIVPSVAALQMKQPRLGDVLIQAGAITKEQLAQALQLQKTTGKRLGEIFISEGIISDTRLAEALSTQLRLPLFSLTRYHPMPEAIKMVPRAVAERLSLIPLTIVDDGLLLITMSNPLDLLAQDEIRMLTGRNLKIGISTHEEIAKNLDRLYNLQNNLEEAIVEIDPDTEINKELDVTASTEDAPVIQLVGNLLQQAVREGASDIHVEAYEKSARVRFRVDGQLYTAFEYPVSLHPSVASRIKIMSGMDIAERRKPQDGRILIRVDGRRIDLRASILPTMNGEKAVLRILDQESSNVGLDRLGLEPDDMEKIQMFCEMPWGIMLVTGPTGSGKSTTLYSMLQRINQPDVNIITVEDPVEFSVAGINQVFVNEKAGLTFESALRSILRQDPDKVMVGEIRDQKTAQIAIRAALTGHFVLSTLHTNDAPSAATRMVDMGVAAFLVSASLSGVIAQRLVRRLCPLCREEYELAPKTCEELRVPVGTRAFRARGCNECRNGYKGRRGIYEIMVLDDDLRRMVLEGASNLDLRNAAIEKGMKTLRQSGINAALAGFTSLEEVLTSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C1</accession>
    <name>D4M7C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_02450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02450"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1702"/>
    <dbReference type="HOGENOM" id="CLU_116157_5_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-151-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="92" mass="10145" checksum="D94D05522269E987" modified="2010-05-18" version="1">MNDLLSLGILYVLGIFVLIYFFTVLPARKKHKRVQAMHAAVKEGDEIVTIGGVIAQVLSRDGMELVLKLNDAGTTMKIVVYAVQSIRKTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E0</accession>
    <name>D4M7E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aconitase A</fullName>
            <ecNumber evidence="6">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_02700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02700"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1749"/>
    <dbReference type="HOGENOM" id="CLU_006714_2_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-170-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="5">
        <location>
            <begin position="48"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="768" mass="84102" checksum="97C9B2E25F5DFD10" modified="2010-05-18" version="1">MVKLYDEGVYLVHGAEVVPESEADKVRQLTGKDADKATALQGTIAWGILEAHNTSDSMERLKIKFDAMTSHDITFVGIIQTARASGMERFPLPYVLTNCHNSLCAVGGTINDDDHLFGLSAAKKYGGIYVPPHIAVIHQYMRESFAGCGKMILGSDSHTRYGALGTLAVGEGGGELVKQLLGDTYDIARPGVVAIYLKGKPAPFVGPHDVALAIVRAVYKNGYVKNKVMEFVGSGVSSMTTDYRNGVDVMTTETTCLSSIWRTDGDTKTFLERHHREGDYKELNPAEIAYYDGCVEVDLSAVRPMIALPFHPSNGYTIDELYGNLKDILQETEAAAEKVAEGRARFTLLDKITPDGKLLVQQGVIGGCAGGNYTNVVEAAHCLKERSCGDGEFCLSIYPSSQPVFTDLDRKGFLADLMDAGAVIRTAFCGPCFGAGDTPANNALSIRHTTRNFPNREGSKPGQGQMAAVALMDARSIAATAANEGKLTSAENFECQWGDVPEHDYDDRAYRARVYQGWGRAAPETELRSGPNIKPWPEMEPLTENVLLRVASKILDEVTTTDELIPSGETSSFRSNPLGLAEFTLSRRDPEYVGRAKAIQALEEERRAGRQPDDAGLKEVFALIKKIPGQESVDPMKVEIGSVVYANRPGDGSAREQAASCQRVLGGLANIVQEYATKRYRSNCMNWGMIPFHLKGRPDAFDVDDYIYVPDIRRALDDDLKDIPAYVLKDGRASKVCLYVQDMTAEEREIIKAGCLINFNRNRRKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E6</accession>
    <name>D4M7E6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SY1_02790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02790"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1758"/>
    <dbReference type="HOGENOM" id="CLU_590123_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-176-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL27791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="472" mass="51541" checksum="561B6CFCCFD570B0" modified="2010-05-18" version="1">MNAKEWKKKVCVEPKNGYERLSAEERERMNAYCTAYKAFLDAGKTERECVQESVRLAEAAGFRPYVRGMALEAGDRVFFNNRGKMLILAVVGRLGLEEGVQMTAAHIDSPRLDLKPNPLYEDSELAYLKTHYYGGIRKYQWVTIPLELHGVVAMKDGRTLSVTLGGERGEPRLVISDLLPHLGAEQNKKPLSEGIKGEQLNLLIGSEPLSGNGGEEGEEGAKDRVKLNVMKLLYEKYGFTEEDFISAELEAVPAFDAVDVGVDASMIGAYGHDDRVCAFAALRAVLDLDAAPERSAVCVLADKEEIGSVGVSGMRTAAFDTFMEDLCQAQNVPLRACLERSFCLSADVTAAFDPNFPDVFDKRNAARFNRGIALNKYTGARGKSGASDASAETVAAVRRWFDDAGVTWQMSEMGKVDAGGGGTVALFMANRNIDTLDAGVPLLSMHAPFEVAAKLDCYMTFKAMEAVCRAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7E8</accession>
    <name>D4M7E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_02820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02820"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1761"/>
    <dbReference type="HOGENOM" id="CLU_059759_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-178-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01830">
        <property type="entry name" value="Hydro_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016938">
        <property type="entry name" value="UPF0317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="DUF1445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029755">
        <property type="entry name" value="UCP029755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="SSF160920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="266" mass="29003" checksum="492DC16FAE03E62C" modified="2010-05-18" version="1">MAKMSDYAGASPREVRRMIREGKWDRPTSGMCAGHVQANLVVLPRDLAYDFLVFAQRNPKPCPILDVTEPGETEPRLIAPGANIATDIPRYRVWEKGKCVDEPTDVTKYWKRDLVGFLVGCSFSFEGALLQAGIGVRHIECDCNVPMYITNLQCRPAGQLKGPMVVSMRPIPHAQVPKAVLCTGRFPSVHGAPIHIGDPAAIGIADVTKPDFGDAVDIRRGETPVFWACGVTPQAAIMAACPEFAITHSPGHMFIADPMDSDYAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F5</accession>
    <name>D4M7F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_02910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02910"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1770"/>
    <dbReference type="HOGENOM" id="CLU_031285_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-185-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="433" mass="48035" checksum="70BC5313B06698F3" modified="2010-05-18" version="1">MFHARALLRGILGSVLAGLLVASALPASAEARKLQFWHVMTGANAEALEEIVNRFNQANEDCAVELVYQGHYRDLFAKLEGAAKAGSLPHLAMIYNNRLISYVKNGFVDPMEPMLFDAGNGFSEEAWADIPAFLRDGSVWDGKHYALPFNKEGFLLFYNKKMLADKGITPPATWEELSAAAEALTGKVGDKDVVGLALNNSVAIDGSFWVEQAGGHIYDEAADRITFNEEPGVKAYEFLVSMIRKGHAKIIREEKYMFGPFGRGEAAMGITYMSQLPNIIELCAANGVEFGSVELPKGVRKACMFTGTNVAIFNTVPEIERRDAFRFLRFFLTPEIQSLWGTRSGCLPLSWKVLNSREFHEFAEKENPAKLAILPSFKYGFSDPKILNGYAIHDNMSKALDAILLENVPVKEALDKAADQAWKEIQESRKSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G4</accession>
    <name>D4M7G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03020"/>
    <dbReference type="HOGENOM" id="CLU_061993_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-194-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061824" evidence="1">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="339" mass="39186" checksum="9CED07064F640AE2" modified="2010-05-18" version="1">MLRRSSIAWKLAFAVLLSFAIAPQMEGAEPKPEWKVDFVNEDLAADFKYMNWRMSIDPFPEEKLSKLKELGCSTDVSRAGMDTLRTAGGADFTEKQFDWILSTLKEKVGVTPDKLTVMDLRGETHGLIDGNVFMYWIPNNYVNEGTPTEKVLEIEAGLLDELKKQDTVKMYQTKDWGADHESPMLEYKKPVIRSEEDLVKSKGAKYVRFADTNHFRPDDHEVDLFVAFMANLPADEWLFMHCYAGEGRTTNFMVMTDIYKNYKVASFDDIAARQGLIGPVDVRTEVATTGKKHYKMKASIERRIFLQQFYNYAKDTDFKGKTWTEWCRERDLTLQYFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K8</accession>
    <name>D4M7K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_03880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03880"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-238-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="313" mass="34560" checksum="8DE0A8AC0190DACD" modified="2010-05-18" version="1">MTRFVLKRLIYALVALFVASSATFFIIHSVPGNPIEAMTEKLPESLRRQTFERYGFDRPLLEQYGLFWKRLLTEGDLGESLRYRGRSVGDILARYAPVSGVLGLTSILWGAGLGVALGVVAALHRGKALDYAVMLLAILGVSVPNFVLASLFQYFLAVRLGWFPVTGWGGFAHVVLPALALSFYSTAQYARFMRASCLDVLSQDYILAARARGMSRFHLVRRHVLRNAVLPIVTLLGPQIALMFGGAFVVERLFSVPGLGFYFVSSVGDRDYTLIMGQTVFLSALYILSILAVDLLYGFLDPRIRFARDGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N9</accession>
    <name>D4M7N9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galK</name>
        <name evidence="15" type="ORF">SY1_04350</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SGP1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1921"/>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_0"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="118"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="291"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="128"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBL27884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="395" mass="43796" checksum="3F09F70E13FF7905" modified="2010-05-18" version="1">MEIKAVYEKMLPRFRELFGEGEPTLYFAPGRVNLIGEHTDYNGGHVLPCAISLGIWALAVRREGNRVRVGSMNFDDRPPTETGRSGIELRVEWGWANYPLGMLSTLEVHRYPIPSGLDILFWGELPVGAGLSSSAALEVLTACVVNDLFGLRIDRLNMAIMGQETENRFIGTQCGIMDQFAVSMGRKGCAVLLNCAALTHLYVLLYSGGYQIVIADTNRRQSAGREDYNLRCRQCEAACEAIRRVRPIRTLCELSVEDFNRLESEIPDPVNRRRARHAVTENQRTLDAARALSLADLRTFGLLMRASHLSLRDDYEVTCPELDALAELAWRQPGVIGARMTGAGFGGCTVNVVERHLVSRFIRDVGAGYELQMGCAPRFYVADAADGAAKVRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7R1</accession>
    <name>D4M7R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemotaxis signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_04800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04800"/>
    <dbReference type="HOGENOM" id="CLU_048995_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-292-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="185"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="312" mass="35290" checksum="F0AFB9BFBADCAA4D" modified="2010-05-18" version="1">MEDRAQAQADVREVSLKTGKKWEVVVFDLGGEAYAINVNKTREILRWQGCRPVPTTTEAFVGITTVRETILPLIDLRVFLGIRSPIPMERTKVMIVEFNDLRLGFLVDSVERIRQVSADDLDSSKMSGISDKWVLYVIKNDARNILLLDYEAIIQDTAPAVARHMFDKNRISAYFNQVGNVEDFHILVADDSPLLRQQICDVLEQSGFSSVYPVKDGAEAHDLLIGKHENFDLLISDIEMPVMDGLTLVSDLRADPCTAEVPVILFSSIMVKDLLERADKLKIVHVLKPDIYKLVEGVMKIYQEKKEREGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T8</accession>
    <name>D4M7T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05200"/>
    <dbReference type="HOGENOM" id="CLU_2422683_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-319-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="91" mass="9325" checksum="CEBE0EDA37335E5A" modified="2010-05-18" version="1">MSTIQSRGRRGRGDRITSVSPSCGVPSRGLSPSFPKIVTGEPTRGAKPPKGPVPAAASREKKAPAAAAGATVTAGTRLRMRPRPSSTSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V4</accession>
    <name>D4M7V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05410"/>
    <dbReference type="HOGENOM" id="CLU_3365138_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-336-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="35" mass="4070" checksum="BE0F2B5C77C84923" modified="2010-05-18" version="1">MRFSLLLQPLALALQAWIKLLIPSRMPLLIRDSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W8</accession>
    <name>D4M7W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAP transporter solute receptor, TAXI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05610"/>
    <dbReference type="HOGENOM" id="CLU_033215_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-350-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061167" evidence="1">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="337" mass="36245" checksum="9681231AA353FB81" modified="2010-05-18" version="1">MKRSFRFAFLILATLALAAGPAAGVDKAGWPDQLRFMAGPPGGNWFALGTALADMWTGAGLPQTTSSSGGGVANIVNANNAKGDLGFSVTSMVGAATQEGGVDFTKGQKMENAVIMANLYTQYTYFIMRRDFAEKNGVKSLGDVIDKKLKMRFATLKPGTSSEFVVKALFDKGYGFDYKKTFEEWGGTVEYASYEGGADLLADNHLDCFAFSVGKVASIVMNIESKLDVVLLPVGQEALDRLSAAYGTETFTIDPGIYKAVPEGAEPVKTVGDYTCIVIRRDLPESLVFELNRALWEHRDSLVAAVKDMEELDPAATVPARVPSHAGSEAFWKTVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Y8</accession>
    <name>D4M7Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05990"/>
    <dbReference type="HOGENOM" id="CLU_1487592_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-370-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="200" mass="23648" checksum="40B55FD964B80438" modified="2010-05-18" version="1">MLDLSRYRVFILCEDQEHNYFVRTFFKSLGIGDRKFDTYPLVDGARSAEGHVRERLPEALDKIRKNRENVFLVLVSDADKNDPNLSDRVKQWNEELHSRGLPKICKEDRVLCLVPKRNIETWFAWIDGEEAVDEIKDYKQRYKKAKAGHYGKRFFEKYTECRSRDARCDDAPQSVRDACTEFGRFCDSLDKHERQRKSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M812</accession>
    <name>D4M812_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Essential protein Yae1, N terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2120"/>
    <dbReference type="HOGENOM" id="CLU_1956410_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-394-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Yae1_N" evidence="2">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="128" mass="14243" checksum="37E373B24924484F" modified="2010-05-18" version="1">MTNDETGVSIVQTTADTVFQRVNDTEKEYWSSFAVRYRQLQEQIAEWDRRAFLKDARNQGLAEGHKQGLEEGRKEGLEQGLERGRALGEAKGRADVVRQLAASGLLTLEQVAQATGMSTEEVKAITSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M815</accession>
    <name>D4M815_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_06370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2123"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-397-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="313" mass="34833" checksum="A5F622AABA045933" modified="2010-05-18" version="1">MVRFIVRRFLVLIPILICVSILVFLVLRLAKGDPAMAYLRMANIPPTEQALAEARRELGLDRPIAEQYAAWAAKAVRLDFGRSYVTGKPVLQEVLYYLPATLTLAGWGLLFTLLVSVPLGVAAALYKDRLADHFTRALAFVGVSMPSFWLGYLLLYLFSVKLGWLPPMGRGGAAHLVMPVVTLSAMSIAVNIRFLRANLLEHMRSRSVFYARARGLTERRVVWAHVMKNSMIPIVTATGMHLGEMLGGAVIAENIFAWPGLGRYAVQSVLNRDYPVLQCFILLMTVIFVACNLCVDILYALVDPRVRLEGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M822</accession>
    <name>D4M822_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_06480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2135"/>
    <dbReference type="HOGENOM" id="CLU_098240_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-404-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="146" mass="15943" checksum="D7C63553DE2C3DA1" modified="2010-05-18" version="1">MTEAQPGRVLALDVGSARVGAAISDPMRLIAQGLAVWPVVDRDGGWRRKFEACLVQYAPTLVLVGMPTRTDGTRGPEAERVAKLVDLLRAGHPDLAFDTWDERFTTVMAHRAMIEGGVSRSGRRQRVDKIAAVLILESWLARQGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M829</accession>
    <name>D4M829_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_06560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06560"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2145"/>
    <dbReference type="HOGENOM" id="CLU_028518_5_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-411-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="300" mass="32895" checksum="2B3AD447607C388B" modified="2010-05-18" version="1">MNDRISQDNEQREQRSLWEEAWRRFRKNRLAILSLVFLLLLAAVAAATILWDFADGRAFYNAHVIKQNLRLRLKGPSAEHIFGLDEFGRDMFLRMLWGIRYSLFMGMAGIAFSTLLGGLIGAVAGYYKRLDNVLMRAMDVLLAIPSMLLATAIVAALGPGLVNVLIAISIAYVPTFARTLRASVLTVKEQEFIEAARSVGADNGRIIMRYIVPNSLAPLIVQSTLGVAGAILSIAGLSFLGLGIQPPTPEWGSMLSNARTYIRDAWHITMIPGAGIMLTILALNLVGDGLRDALDPKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M833</accession>
    <name>D4M833_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_06620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2154"/>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-415-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="332" mass="37421" checksum="ADFAF576F1B776DB" modified="2010-05-18" version="1">MEDAERERNGELIGPALGPVTAGQIEADLERGKIYRLNDRFFKFLFGREERKPLFLDLVNALVFPDGSAGFTDFEYANRELSAARVEGKDCYLDIVANMADGTQVEVEVQVRNWNDYLQRSAYYLSTLHASQMGLGGSYLDLKRTVSIHILAFSLFSGERFRREFCLCDVESGEKLSDDLKLIYLEVPKYASYGTPRNRLEYWLMYLAGMEAKKMPEAMVKDPMIGEALNLEKLFLQSREERQRYIVSYKAMRDAMTRDETIRRVARAEGEARGEARGEARGLAKGLNEGEAKGIAATARRMLARGVSSEQVADFTGLSPDEVEALRVGIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M834</accession>
    <name>D4M834_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Epoxyqueuosine reductase QueH</fullName>
            <ecNumber evidence="5 12">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Queuosine biosynthesis protein QueH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">queH</name>
        <name evidence="13" type="ORF">SY1_06640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the QueH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="5 12"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06640"/>
    <dbReference type="HOGENOM" id="CLU_088177_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-416-MON"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02089">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003828">
        <property type="entry name" value="QueH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36701">
        <property type="entry name" value="PTHR36701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02677">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="197" mass="22080" checksum="B505C55D9E638527" modified="2010-05-18" version="1">MTDREEALPAGRRLLLHICCAPDATVPARDLTAEGWQVTGFFYGSNIHPREEYVRRLTTLHRLMAHEGLPLEEGPYAPEDWIVHMERSGLMEEPEGGRRCTECFLMQLASAAEAAVRLGCTHLCTSLTTSPHKDVERIARLGTACAASRGLTWEPRVWRKRNGFLRSLEISRELGLYRQNYCGCVASLQGLPVECAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D4M839</accession>
    <name>D4M839_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SY1_06730</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2166"/>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-422-MON"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="7"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBL28034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="414" mass="44230" checksum="D4517DF7E4680F2D" modified="2010-05-18" version="1">MSATRRVVVTGLGPVSPIALGKDAYWKALREGKNGIGPITTFDLGDCPVTFGAEIKDFDPTLWMPGKEAKRSDRVIQFAVAAARMAVEDAKLDTSAMDPYRLGVYIGTGQGGIETSFNNFNTMLTKGSRRVSPYFIPMMISNMSTAYVAIVLGAKGPNLCVVTACATSLHSMGEAYHTIVRDDADVIVAGGTEAALRTISIAGFAAMKALSTRMDSPETASRPFDRDRDGFVMGEGAGVVVLEELEHAKARGAHIYGELVGYGTSCDAGHITAPDPEAEGAAYATRHAMKMAGWRPEQVDYVNAHGTSTGLNDKMESFMIHKVFGERAKDVTVTSTKSMIGHCLGAAGGLEVIASLQAIEENYIHPTLNYTTPDPECDITLSTGRGVERKVDRLLVNSFGFGGHNGVLAFQRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M845</accession>
    <name>D4M845_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06800"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2173"/>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-428-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="188" mass="20684" checksum="BC0AA887190D0958" modified="2010-05-18" version="1">MDFLKLARERYSVRKFTSEAVESEKLDAVLEAGRLAPTACNNQPQRILVLDTAEALDKLKDCTPCHFSAPLALIVCYDDTVSWKRPYDDKDMGEVDASIVTTHMMLEAAALGLGTTWVGHFDPQKVRSAFALPENVIPVAILPMGYPHETSVPKAWRAPSAFGDDAPRHLLNSPLLHGGVLHSQRPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M853</accession>
    <name>D4M853_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_06910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06910"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2181"/>
    <dbReference type="HOGENOM" id="CLU_065103_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-436-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="295" mass="35006" checksum="8AC1AD08490B0F24" modified="2010-05-18" version="1">MTVNKDKYTIGQMAKLCNVSTKQLRFYDERGLVTPAYRDEINGYRYYERRQIEEILLLSELKQYNFSLEKIGRLLRNRELNPLQKELEQQLYELRRERKDIMAKYDSIIDRILNILHSSVYLIANQKTFAQDIISVQTFPETVVAYTRYVSYWHVDQLFTSRRAELFKFLSEHRLEEMGANMAFFYNGYKKQFSENPDDREGDLEVCIRIKNPDLSLPCVRVVEEFQAVSCIYVGPYRDMLPAYLDLESYARQHQIPLSGESLEEYLIGASMTANPNDYVTRLYLPFAREKRVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M865</accession>
    <name>D4M865_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">SY1_07190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07190"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2208"/>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="132"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="190" mass="21372" checksum="E4F2EFE441B3D8AF" modified="2010-05-18" version="1">MAQVVDTTDFYVGLKFRWQDGIWEIVDYDHHKMGRGGAVVRTKLRNVETGSTVENSFKPGEKFERIIYEEKPAQYSYRDGEDYVFMDLATYDQMTLSPKVLGEAAKYLVDDLEIQLEFFEGKVMGIELPKSVTLKVTDTPPSFKGDTVTGGGKPATLETGLVVTVPVFIEPGEEIVVDTRTGLYLERAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M881</accession>
    <name>D4M881_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_07420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07420"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2230"/>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-464-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="312" mass="35638" checksum="A358D60D1CAA387B" modified="2010-05-18" version="1">MTCGREGLTTELSPEELERCVRSANLLNDVVFKYLFATKGNEENLLRLLNDVLAPGPGIVSLQYLDRENDPRRDEGRTSCVDVLARAEDGRVCHVEVQLGREGYFFERALYYASCSYSDQLSVSDSYDKLRPVIFVSILNFCLFPDRAEDWRSLHRLLDVKEQRSYCDGMEFHFIEMPKLKRLTAAGRVEDVGLSRVMKYLGRIGGEVEMERLVKCDRGIERLEDGVRTFFRKRGNLALYRMRERAETDYRSNLKFAVQEAMTEGENRGRDLGRVETARRMLDMSLSPSQISQATGLSLDEVEALKDNAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M894</accession>
    <name>D4M894_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_07670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07670"/>
    <dbReference type="HOGENOM" id="CLU_697842_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-479-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="133"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="327"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="395" mass="45531" checksum="AA96EE00D811E8FE" modified="2010-05-18" version="1">MKRSLSDFVPLLLKDEGLPEIIDEIRAELSFGVAWRELDTGNVLCRGNPAFEERMLSFPLREIVRIYVSHEVEVSGNAIGLLVLDLPKGLPGPLPERLEDCLSVLRLFYGQRLAESRLKTRYRNEFVQDLIYGRIYHEEEIRNRARTFHWKLDGGIVCLVISPELTETTGAVLDEALLSGFNLIQSRVLAFFPKSVYARLPDSLVVVLTLALPEERGRETRLRDFRAALREVMENALHDARDRCRIRFFASVGSWREKPILAYQSYQEARQALMILRGGMSRQDFVFWEQLGGTRMIAMLADMEPAREFCRQTLAPLLRESRGGEELIHTLLRVEECGGDLRQAAKSLSLHYNTLRYRLRRIQEILDLSPHDGERRFNLSLALRLHRVLSKNRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B6</accession>
    <name>D4M8B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_07930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07930"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2286"/>
    <dbReference type="HOGENOM" id="CLU_039483_8_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-504-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="374" mass="40657" checksum="52022B99E2B6D154" modified="2010-05-18" version="1">MFAQRLWALTKKEALQIVRDPSSIVIAFVLPLTLLFLFGYGLSLDAREIRIGIALEDGGQPARDLARRFAANPYFSPSLAASRQELLPALVTGELKSVLIVPQGTSAALYFNQNLNQNSGRKASLQLLTDGSYPNSGALAENYALAAILQWGGELSRTSLPIVVEPHFRYNDGLESRYSLIPGIMAVIMALIGTMLTALVVAREWERGTMEALFSTPVSALELLLGKLIPYYLLAIFSTFFSLALSVSLFGVPFRGSLPALFAVASLFMMSALGQGLIISTLSKNQYVASFAALLSAFLPVVLLSGFIFELNSMPLVQRAIAAVLPARYLVTCLQTLFLAGDVWPLLLPNMIRLGLLGLFFLAVTLRYTKKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8B9</accession>
    <name>D4M8B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_07960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07960"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2289"/>
    <dbReference type="HOGENOM" id="CLU_000604_83_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-507-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="348"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="380"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="594" mass="64284" checksum="0ADD6F6DCA14EB65" modified="2010-05-18" version="1">MSEVEKRLPIDSQKTSEIVVEGLVRTFGKRTALDGITARIGGGRITGLVGPDGAGKTTLLRLFCGLLAPTAGRVSVCGCDTAEDADAIHERVGYMPQRFGLYEDLTVMENLNLYAELRSVPRRERTDRYAELLAFTGLEPFTGRLAGRLSGGMKQKLGLACTLLSRPPVLLLDEPGVGVDPLARRELWRMVRGLLVRDRIVVWSTAYLDEAEACDAVLLLNEGKLLYDGTPEDLAKRVEGRVFLLGGAGGRRRKLIAPLMERKCTLDAVIQGSSVRVLTSDDGAELRENLDAIACEAEVLADPSSRLTLRPAPPRFEDSFMQLLGGARRGSDAVAAFFEEKGTGRVSVEARHLTKRFGNFTAVDDVSFSIERGEIFGLLGPNGAGKSTTFKMMCGLLTPTEGECAVSGLDLRTAPGAARARLGYMAQKFSLYGDLTVLQNLRFFSGIYGLRGDAALERVVETFGLAPYLSSRAGSLPLGFKQRLAMGCAVMHGPDVLFLDEPTSGVDPVTRREFWTCINSFALKGVTVMVTTHFMDEAEYCDRIALVYRGGTIASGPPDALKASVRTEACPDPTLEEAFIALIERQDAAPASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C4</accession>
    <name>D4M8C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_08020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08020"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-513-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032255">
        <property type="entry name" value="HBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01358">
        <property type="entry name" value="HBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="334"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="408"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="708" mass="76161" checksum="DB479377C1E6CD05" modified="2010-05-18" version="1">MFRNMRISLKLSLGFGLVLLVFVVAVAFSRAKISGVQEDNRLMAKISEVLALITDLNDGISGLRFSARGYLYAEDADDMKTGRDSLKALEEGIARGERMYREDPRLVALSRISDLKGPLEAYSKNMEEVVSLAEAKRNTVQGLAKDSQEFLDKLNEALVPIYRKLQNDISAGNATEAQRRLERVREGEALTTEIGEVRRSYSWVMANRDVSGIDAILSRVDAMGKRGQKLLDDTRSEEIRRDLADALTHLHAFSTGVRELADQLVRISELTKIVKQQGDDLDELSDAIFDVSQKRTRGIITQTDDNLSLSVLMLIALTVVSVVVGLLIAFLISRMITKPLSLLVSVAERAGGGDLTLTRADLGEERNDELGKLSDALIEMVGAQRRTITEAMEIAERSAESADTMRTSSSQSSESIANAKQAIESVVSLCESNSSSLQESNAGTEEMSAASMTAAQAATDCAEFISQTTVVSGQAVEMVQETIEDMGLLFKKSEESGERLRELVESVGQISGFVGVITSIADQTNLLALNAAIEAARAGEAGRGFAVVAEEVRKLAEDSGQAANNIKGLITTLQAGARDTMNSSTESSELLTRTTEKADKAKESLNEAMGQIDKANDRIQNIAAVAEEQAASSREIASGIDAATKSTVDMLQNMERIQSSSDETARVAEEVAKQADGLAVLADRLKGALSRFKVSAGASGAGRAALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G4</accession>
    <name>D4M8G4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="6" type="ORF">SY1_08720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08720"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.69"/>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="134" mass="14873" checksum="5FC3EA6E33200788" modified="2010-05-18" version="1">MYVNDPIADMLTRVRNANMIYSESVDVPASKMKLAIARILKDEGYIKNVKTITDPKKPYASIRIFLSYGPERERVIQGLRRISKPGRRLYVGRDKLPVVMGGLGLAILSTSKGLKTGAEAMKLGLGGEVLCYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I0</accession>
    <name>D4M8I0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="4 11">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SY1_08940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="4 11"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08940"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.93"/>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-573-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03137">
        <property type="entry name" value="AhpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="187" mass="21110" checksum="388C6037B09B2918" modified="2010-05-18" version="1">MSMINKEVSDFKVQAYHKGEFKTVTKADILGKWSVFFFYPADFTFVCPTELEDLQNKYADFQKAGCEIYSVSTDTHFVHKAWHDESERIGKITYPMLADPTHALSRDFEVLIEDAGLAERGSFIVNPQGRIVVYEVNAGNVGRNADELFRRLQASQFVAEHGDQVCPAKWQPGAETLKPSLDLVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K2</accession>
    <name>D4M8K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted periplasmic protein (DUF2233)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_09390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.140"/>
    <dbReference type="HOGENOM" id="CLU_548303_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-595-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061533" evidence="1">
        <location>
            <begin position="32"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="307"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="497" mass="53457" checksum="B8A8AF13C4C215C2" modified="2010-05-18" version="1">MRFHFSGLRARSRALCLAAILFLAIPCRAEAVTRGAFLAALLDARGLSSNVPVGKNAVAFVQETGIVTDGIGGPNAQVTRREALRWCIQSLGLAFEAGALSDVSAGFSDEKALTPFERGCLAVAVNMTPALLSRDRSFRGAQRLTEKEMRFLLDRVSQASEGLSLEVTLTPVEGLTLLLHRDGVPTGVPRWRVYADGFEDKAAAESAQAFFKSKGFEMSMLQPQYEWFLRSPVLEDYGAARRLASLIRQRKLAVCLLPSVSNSNTDILPRYWALLTIDPGLWRMVPAASSEGPAALTPLSRIVKDNGLSAAINAGFFAVTGRRQGYPIGLLRRDGAEVHKLYNGRGCLGWNDENEAAFGLPSLVNGELVGAGGESWSDMPFAIQAGPLLLSDGVVQGNDEGFSNSLLSARHPRSVVGLTADGEWFFLAVDGRNGLHAAGATMSELTDILRSYEVPYALNLDGGGSTELIVKGRLFTFPSEGRERPISYALGVVPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K4</accession>
    <name>D4M8K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate/nitrite family of transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_09410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09410"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.142"/>
    <dbReference type="HOGENOM" id="CLU_036896_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-597-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00790">
        <property type="entry name" value="fnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01005">
        <property type="entry name" value="FORMATE_NITRITE_TP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="278" mass="28802" checksum="9FA66BD8D44BF251" modified="2010-05-18" version="1">MQSNFLSPAEVAELVVGVGQRKAEMSVTNQLILGVMAGAFIAFGAAGSCVAVHTVESAGVAKALAGALFAAGLIMVVVAGGELFTGNSLMLMALAEGRISPWQLLRSWLVVYAGNFAGALLTAGLVCLSGQWGMSGGLLGASVIKTAAGKTALSFQNAFFLGILCNWLVCLAVWMSFAARDIAGKVLVIFFPIWIFVTSGFEHSVANMYYIPAGILAAADPALAERAASVGLSPEALANLNWGAMLQANLLPVTLGNVVGGGVLVALACWFVYRRDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K5</accession>
    <name>D4M8K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SY1_09420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09420"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-598-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="247"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="10">
        <location>
            <begin position="318"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="616" mass="65122" checksum="1870B824FD5E8F92" modified="2010-05-18" version="1">MRQSYIDAENPDAGARNVEAICEKILKNAEDKNILNLYLALESTGLLAIASSEGKWVAPAGYDARTRGWYQQAVADRGATKFSAPYVEAASGKLVIAATKAVYDDSGKLVGVASIEVDLDKLSAFVVSQKVFGQGSGALVQKDGTFIAHSNKDYVLKANLLNGQEFDASVHQFAVKVVGGGTGFADYLNNGERRRVFYAPAGHDFFFIVFFPISVIHSMVHGLTVFLVLIAAAALLVIGFLIFAIMRSLSRSLKGMSAATVELGRGDLTVRFDETGRDELSGMSRELNAMIASVSETLRNIRIEADETSRQADTLAALSEETLASMKEVSASIERVNGVVSSASSATEETRASVSEIADSAQSSAQSATESAEQASRVADVSKNAVDEVGAVVTGMREAKDKSSHSIAQIQELGESVNAISSFVTTITSIADQTNLLALNAAIEAARAGEAGRGFAVVAEEVRKLAEESAHAAQEIEKLIAGLQKHSESSVEATKETEKLLIETSATAEVTQQKLNGAMDAIARLNDAIQNIAAISEEQAASSEEMTSAIQHVADANHGVVEAADSIQTATRETTRAAESIAGAAQGLASTAEKLQGFIGSFFLEKQGDIVPKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K7</accession>
    <name>D4M8K7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">SY1_09450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09450"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.147"/>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_0"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="131"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="284" mass="29672" checksum="821CEE33138D702A" modified="2010-05-18" version="1">MTVVMKGAEVAVGMKEALLAEHAELKGMGVDPKLAIVRVGARGDDLAYERGALKRFAGLGITTQVYELPEDIEQADFDAEFGKVNADPKVHGILLFRPLPGGLSDEAARRTIDPRKDVDGMSPISSAMVFAGARDGFAPCTPGAVMEMLAHYEVDLKGKNVTLVGRSMVVGRPLAMLMLAANATVTICHTKTVDMPAVCRRADIVVAAAGKAGMIGADCVTDRSIVVDVGINVGPDGKLCGDVDFEAVSSIVSMVSPVPGGVGAVTTSVLARNTLRAARLLTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K9</accession>
    <name>D4M8K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09480"/>
    <dbReference type="HOGENOM" id="CLU_2751978_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-602-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="70" mass="8013" checksum="E1B86BBAE545202A" modified="2010-05-18" version="1">MIQAVAAKRKSLYRQLQNLTEEDLDRVSHYAAFLQYLEAQEDEEDIVWIEAHKDDPTVPLADALKALGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8L0</accession>
    <name>D4M8L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="9bact-d4m8l0">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09500"/>
    <dbReference type="HOGENOM" id="CLU_026209_7_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-604-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="274" mass="29961" checksum="A14ED26A23CC9877" modified="2010-05-18" version="1">MHEALIRSFDGTELYRCTDEAPGAALGSVLLLHGLGGHCRRFDAASAAMATAGWRVTRFDLRGHGRSGGARADVRDYRLLVKDVRLMADAALAERPGPLFTVGYSMGGLLSLLLGVQRPEGISGQVLIGAPTLETGRYRNFRRPQVQRLLMRCSPSVGEDLLTPDEAARHEYERDPWVLHAFVNRLLVEVFVKGMDDLTAALPAHRLPFLALHGSEDRIVPPASAENLRVRSASPDGTLTILEGAWHDLLHGPERDRAMELILGWLKAHAAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8M2</accession>
    <name>D4M8M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09640"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.166"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-616-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="125" mass="13323" checksum="83F18115046D149A" modified="2010-05-18" version="1">MKKIISCDKAPAAIGPYSQAIQAGEFLYVSGQIPANAKGEVVQGGVEEQAKQSLENVKAILESAGYGLKDVVKTTVFATDMANFAAVNGVYAKYFDAEAPARSFVAVKALPKEVLVEIEVVAWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N0</accession>
    <name>D4M8N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1858 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09830"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.183"/>
    <dbReference type="HOGENOM" id="CLU_180540_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-624-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="76" mass="7936" checksum="1360FC0722A31547" modified="2010-05-18" version="1">MAEAVKAAEPFEVTKATTMGEMLAHDMGIAQVLMRSGMHCVGCPSSIGESLEDACAVHGLDADQVLAAIKEYLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8P8</accession>
    <name>D4M8P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10080"/>
    <dbReference type="HOGENOM" id="CLU_2450322_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-642-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="89" mass="9671" checksum="DEF49FBA113FBC22" modified="2010-05-18" version="1">MLREEYLTTAEAATLTGKGANMIAKLCQAGRLPGAEKMGNSWVIPRESVLKYQPSKRGVKPRSERVKAERAALREEVEAAISAARGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R7</accession>
    <name>D4M8R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10490"/>
    <dbReference type="HOGENOM" id="CLU_1608439_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-668-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="165" mass="18426" checksum="2C6E4B1FC94E83DF" modified="2010-05-18" version="1">MSKNRIVLFGVLGVVMGLVLGVFGRDFIVASEKQKLEAQKAEEAVATSIIVRLKQASTDLSMFRMKNGKEIGENYDLGAALNTPERIREKLGDIYADGRWVFQSNAAGWWIGYKLDGVSNAVRQKIASQARFSNLFKATDKSDANVYDGGDIVFLYDYVPETFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8R8</accession>
    <name>D4M8R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10500"/>
    <dbReference type="HOGENOM" id="CLU_1608439_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-669-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="181" mass="20519" checksum="5358817F8885552C" modified="2010-05-18" version="1">MSKNRIVLFGVLGVVVGLALGVFGRDFIVASEKQKLEAQKAEEEAKIKAMMTGIPVDASQEFIAAKTLVDDMKSLKAMLLIFYMEHIEQEVDLTKTLDTPEHIREVLKKKVRNVEKYLDGNWIFQGNTSDWWIGYNLDDGFKKQASEIGKELVKRAERNGLYKDMNGNLYDGGGKVYMKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S5</accession>
    <name>D4M8S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.271"/>
    <dbReference type="HOGENOM" id="CLU_174000_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-676-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="67" mass="7427" checksum="0E193445662B3ED7" modified="2010-05-18" version="1">MVVVFDEDTPRELLSRLRPDVLAKGGDYRAEELPGREFVDEVVILPLLEGHSTTRILNHGREGGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8S9</accession>
    <name>D4M8S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_10730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10730"/>
    <dbReference type="HOGENOM" id="CLU_2806244_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-680-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="67" mass="7613" checksum="4B6C0CE2F0F69FAC" modified="2010-05-18" version="1">MSDNYPSDYPRSRAKAIAALRTVRDEDIDFSEIPETTNFSNWTPVGEKFKKAAEHNLTVLNEKIRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U8</accession>
    <name>D4M8U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11010"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.312"/>
    <dbReference type="HOGENOM" id="CLU_051402_4_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-699-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="141" mass="14585" checksum="D6B90C69CC37A36E" modified="2010-05-18" version="1">MNTIGLAYFSNTGNTKALAEAFKSAVEAKGGSLYFSEAAGVDKAAFAAADVWAFGSPASGTEEINDTEVLPLIEALKDHLKGKKVFLFGSYGWGGGAFMDAWKQDMEGRGAVIAAEPVTCLEAPDGAAESAMRQAAEALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8V3</accession>
    <name>D4M8V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_11100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11100"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.321"/>
    <dbReference type="HOGENOM" id="CLU_042763_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-704-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="376" mass="40659" checksum="A5BE81F3A6506651" modified="2010-05-18" version="1">MSKAGKNWNPLTFLADNAVPIVFIAISAVAIPLSGFSFSHLVQELLIRIGRNSFLILSLLIPIMAGMGLNFGMVLGAMAGQIGLILISDWAIVGIPGMALAMLVGTPIAILLGILCGNVLNRAKGQEMVTSYILGFFINGLYQLVVLYFMGWLIPISNPVILLSRRYGVRNTVNLQGIRGVLDNLVPVSFPFFGGTVRVPLATLLVIAVFCLFIVWFRRTKLGQDMRAIGQSQSVADSAGIAVNRTRIIAIVISTVLACYGQVIYLQNMGTLNTYNSHEQVGMFSIAALLIGGASVSRASIANVFAGVVLFHLMFIVAPMAGKNLMGQAQIGEYFRVFVSYGIIAIALVLHAWKRNRDREASRRSLRGPAEGREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M903</accession>
    <name>D4M903_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type amino acid transport/signal transduction systems, periplasmic component/domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11900"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-756-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="30"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="274" mass="31232" checksum="8F898DB23C67B150" modified="2010-05-18" version="1">MKRFWGWGLILAWVFIACISREGIASEDKVIRVATPGTYAPFTMYDEATQEWSGFEIDMWRTIGEKAGYEVQWVRLDNPATFAELDLGRVDTVAKQISITPVRQQKYDFTRPFFFSPYCLTVAADNEAIKSWKDMEGKTIGLSEGSAMNEFIAAMDPENKVKKSVYGSGSSILHEVAMGHVDACPYAFLVLPYRLKKNPELKLKSVDIENPIYVEVNVYPFARTDRGRELLKLTDGVLTQMIEDGSYAKLCEKWFGTNVMESKYAKEYREKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M909</accession>
    <name>D4M909_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in archaea</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_11960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11960"/>
    <dbReference type="HOGENOM" id="CLU_074324_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-762-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003748">
        <property type="entry name" value="DUF169"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37954">
        <property type="entry name" value="PTHR37954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02596">
        <property type="entry name" value="DUF169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="183" mass="20789" checksum="C76B4D3BEF17BD5F" modified="2010-05-18" version="1">MGIDPSDPKNAHGENWARLKLYDSEKVAADVRKGLTYSKEPKYGLFLAPIEDMDKRPDVVLIVANPYNCMRIIQGYAYHHGMPASINMIGNQAVCLECTARPYVTRDINISLLCIGTRHRAGWGNDEMAVGVPQEQFADVVDGIVQTINQMESDANKEMIKKKFRDKNIPISIRFHYNYYMDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M947</accession>
    <name>D4M947_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein ChrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_12560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12560"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.491"/>
    <dbReference type="HOGENOM" id="CLU_018106_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-800-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="193" mass="20421" checksum="8D1BC0025E623B91" modified="2010-05-18" version="1">MSTVLLLMGVFAKVALGAFGGGLATIPFIHRELVELHPWLTEEMFGQTVALAQMTPGPVALNSATFVGYRMAGFWGSLGASAAVVGAPLLAIALLLWLISRASQRAQGRIAAFEKGLRPAVAGLLFVAFCTLARPLLPAPSSLRAMLPRLALIALAFLCLALSRLRPFKAYPQLLILFAALMGLLLRGLLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M948</accession>
    <name>D4M948_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_12580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.493"/>
    <dbReference type="HOGENOM" id="CLU_033405_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-801-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="148"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="435" mass="45652" checksum="71012ADAE620E0E4" modified="2010-05-18" version="1">MLTLVFAVFAALMAGSLACGYSMLWALAAGFAGFMGVGLRRGFALPSLLRMAWRGVRESLIVVRVMLTIGVLTGLWRAAGTFALLTAWGLRLLSPSTFILSAFLLSCTLSYALGSSFATAGTLGVALMTVARSGGVNELAAAGAILSGIYFGDRASPASSCANLVAALTSMDLYDNVKLMMRTAFLPLLLALGLHAWLSFKNPMLGGEGAVLTSLNLDFHLSPWCALPALVMLVLPLFKVKVLHSFGVSILCAFLCAVLLQRTGTAGALRFALMGFHAPEGSVRAIFNGGGLVSMLEISAALMISGTFAGIFDGTGILKGLQSRLVRAMDALGAYPVTLTLGTLANAVFCNQTVAVMMTVHVVRHPYGERGLPPAELAQDLANSAVITAGMVPWCIGCSVPLTMMGAGAGAVPYAAYVYLLPLCYLLTRRRWFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M957</accession>
    <name>D4M957_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate/tyrosine/aromatic aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
            <ecNumber evidence="2">2.6.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_12760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EC" id="2.6.1.17" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12760"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.508"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-810-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009016">
        <property type="term" value="F:succinyldiaminopimelate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="383" mass="41733" checksum="8DA6FAF32086069F" modified="2010-05-18" version="1">MRVAERFSKFKPSGMMRMFRAIAQMEGVLNLSIGEPDFTTEPDVIDAAARAARAGSTHYPPLQGFRDLREAVCGYWERRHGLSLSPEEVVIANGALQATQLLFEALLDPGDEVLLLEPYFTVYAVQVRDCGGVPVGVPTREENNFAPTAEDLRAAVTSRTRGIVVNSPGNPSGSVYSREQLEVIAAFAVERDLLVISDEIYESLVFRGEHVCFASLPGMRERTITIGGVSKSHCMTGWRLGYAMTPPDVASMMCLLSSSRTYGVCTLAQKGAAYALNTQDAKVEERRAAFGDRLRAVEARLNAMKGVRCRPAAGAFYLFPDISGTGLSSEEFSLRALREARVGLLPGDAFGESGEGYVRIACTQAMDSLMRAMDALERFTDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M990</accession>
    <name>D4M990_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_13340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13340"/>
    <dbReference type="HOGENOM" id="CLU_426265_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-846-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="582"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="642" mass="70427" checksum="D07BA5590837B568" modified="2010-05-18" version="1">MLSMKGLFRVPEVFPWGAKRFGALVSVLALSLTHPGLPAEAAQPGILMAGEPHVGTEVVLTADPASVPPDAVIEWAISGDVKPVLLRAGGRECAFTPVNTLPIKVTAIVHDHSGASLGDAETTVTPKEYDVEIVVVSRDLVTLWDATEKTSVSEDALMTNRPIRLRAQFVPAFSGEASFSWIADPSTAILSADGGSDLVIFRSEAGDSEVAVSAFNRAGVFLGSGSSTIGVTLPSAVLQESEVARRAWETWERAEEAWDAKDYAKAMRLGAEAQAAAPRDQDIAKGFRAMATKHSRFLRALDFRDKAADQIAKGFHDDGLKSLRLAQVVWPTEEGEALIRKEEEEIDELRVKRQRAEWLRDTASAYDQERLFEDAIAYYERSAAVLSSDAIQERTARIRQRLELMADANRYASEGSAMERDDDIEGAIAHYSASIVSNPDAALKQHIDELRVVLERRKRQAAALYQEGQALARKGNAKEALIRYLESRRVWDTEAAQKRIDELERVVSVDSEPRGPEDFGIGTRADAARLARFADALYLNRRLEEAAPLYRKSLAIFPNEELKAWVERVEAILHDRRALQAANAKVREGNAFLNAGKTAEAMACYREALAIHPNAEVEAFLARSGEHPTQEGPAPASAGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A4</accession>
    <name>D4M9A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13580"/>
    <dbReference type="HOGENOM" id="CLU_108696_20_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-860-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="73" mass="8283" checksum="873F35D9CB6D7E65" modified="2010-05-18" version="1">MTNEEKLALLIETIEADPKDVKPDTLLETLDCWDSLSKLSVLAMFTARFNRDVGVDAVRGFKTVDDILKEMHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9B2</accession>
    <name>D4M9B2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_13690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13690"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.601"/>
    <dbReference type="HOGENOM" id="CLU_014823_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-868-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061756" description="Dipeptidase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="545" mass="61959" checksum="359861F3E5744179" modified="2010-05-18" version="1">MYRRNFRALKVFFSALLLLGLLSGAAFACTVIAAGKNATADGSAMITHNDDSRTANSRLFIVPEADWPEGSMRPLIKDAHGYEGDAQQLDEIPQVPHTYRYFFSRYSFMNEKGVAIAEATNGVQVTDARSEKIQQIMEKDAAGSLDAWLIQDVMLERAASAREAVKIMGDLVEKYGWYDAGETMPLTDGNETWVIEFYGNKIWAAWRVPDDEVFVAANRARLRHLDLTDKENVMYCPDLVDFAVKNGFIEAKDVNEKDFSPADVYSPSTELYSTRREWRALSLLAPESFKMGPDEYDYPMSVKPDRKLTVQDLFMIKGDWYAGTSFDLSQGIQAGPWGNPIRFANSSKENPDASWERSINMMRTCYVHIAQVRGDLPEEVRGISWYGYGAPDTTYITPLWPIMRALPPLYSIGDRFHPYDPKSGWWTCTRVQEIAGLRYQDAREEIHKARDAKLKPLYLQAPLIQNAAAQLIKDGKRDDAIDLVTDFAYSHATDWHDRWQSLGDRLLSKYALGYTDVKATPYPEWWNKTVGFDTLRRSSKEAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G1</accession>
    <name>D4M9G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14750"/>
    <dbReference type="HOGENOM" id="CLU_1893143_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-917-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="134" mass="14987" checksum="13E1C7FD0ABA032B" modified="2010-05-18" version="1">MNVIKRALDRCEVEFLLLGMMVVSPMADSLLTATGWGEILLQSFFVAICLLFIYKVVVSKSPNWAWAAWGSFCCLIVPVALFGYFAGPGQKDSHVKIVYSLLNVLFIAIVLLRTCFRLEDLKRAENASSHDSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G3</accession>
    <name>D4M9G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14770"/>
    <dbReference type="HOGENOM" id="CLU_1872412_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-919-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="136" mass="15783" checksum="EBC7125E8DC61830" modified="2010-05-18" version="1">MNSDRLPLRWGNLWRIFWASLDELSFGEMLWRMPLVVAIAYASGYEMGAKNMLKPAEPYAPMVWTYYGVSWLIFVVFRYYFLPSHWFPWMQVVAGFLYGGILGVLTSLFYHASLEQTVTIVVCGAVSILILILRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H1</accession>
    <name>D4M9H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14880"/>
    <dbReference type="HOGENOM" id="CLU_1692936_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-927-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="155" mass="16986" checksum="648E379324A4DA94" modified="2010-05-18" version="1">MREDRMRRKVLSISAGGLRRRGAFALGEALILIIVVLIVFGGIFGSMAMTMRMRAFTQVDLDARLVAQSWFEAMGTTDKSMLKSSSTMFFDAVADRLGWVHEESAYRWGGMIVTPSMTPAVGGSYPIKLDVARSDGGKLTFAGFVSAYEERSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9H4</accession>
    <name>D4M9H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol 2-dehydrogenase (NAD+)</fullName>
            <ecNumber evidence="8">1.1.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_14930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14930"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.752"/>
    <dbReference type="HOGENOM" id="CLU_044754_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-930-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008888">
        <property type="term" value="F:glycerol dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Fe-ADH" evidence="7">
        <location>
            <begin position="8"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="374" mass="39243" checksum="495DCCC73BC4058B" modified="2010-05-18" version="1">MARIFISPNRYIQGAGEMKKVGEYTANLGSKALVLVSQGGKKRSGAEIEASFKASKASCQFEIFNGECSRKEIDRIAAVVKGAGCDIVVGVGGGKIFDTAKSVANQAGTPVVICPTIAATDAPCSALSVIYTDDGKFEEYEFFKANPNVVIMDTDIISKSPVRLTVSGIGDALATYFEARACMRSGAVTCAGGKTGGAAMAVAKLCFDTLMAEGVKAKLALEAHACTEAVEKIIEANTLLSGIGFESGGLAGAHAIHNGFTILPECHHMYHGEKVAFGTLTQLVLEDIPQEELQAVLRFCVAVGLPVTMKQLGIEDPTPEKIMSVAKAACAPNDTLHNMPFEVTPEKVSAAIFAADAIGRQALKDYKPVGGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9J3</accession>
    <name>D4M9J3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_15260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.784"/>
    <dbReference type="HOGENOM" id="CLU_020529_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-950-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="345" mass="36588" checksum="F1FCBFFAB24F56A3" modified="2010-05-18" version="1">MRREHGTVEGVSAMGPFALEPVCKDYLWGGTRLRDEWGLGGGMPRVAESWSLSAHPDGDGRILNGPCAGMTLSSALRRLPQLAPQDAPLPLMVKLIDAALPLSIQVHPDDAYAAQHHGEERGKTEMWYVLDRTPGAFVYLGFRHRVSRREAGLRARDGTLPEVLRRVEVRPGEALFIPSGTVHAIGGGILLAEVQQSSNLTYRLFDYGRLGADGRPRPLHVERALDVARLAPADPTPPGALPWQALTGGQLRVLANCPAFRSGVLKLEGACTIPAQRRFLSLLCLAGEAALSGEGASLAMSRGTSLLIPAGGGACRLEGDAKLLLTSTGGGGSDNFAFTIGGINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9J5</accession>
    <name>D4M9J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TRAP transporter solute receptor, TAXI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15280"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.786"/>
    <dbReference type="HOGENOM" id="CLU_033215_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-952-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="316" mass="32549" checksum="480F30F43158C91A" modified="2010-05-18" version="1">MVLALLSAGAAVAAEKGGMPGGGTLTFTTGGAQGTYYGFGGVLAGKVGETTSTTVTAITSGGSQANVEAMDAGDAQLGFVQTDVGAYAYNGTRLFEKQGKVEGFSTVANLYMEQVQIVTLNPDIKTVADLKGKNVSVGAAGSGVFFNAVDVLTAYGLDVEKDIKPTYQSFGDSVDALQDGKIDAAFIVAGAPTTAVTSLAATKKVSLVSLDEEHVEALLKASPYYSRNVIKKDVYNTDGDIATVAVGAVVIARDDVSEADVYNFLYGVFENLDAIKAAHAKGAELNLDFAASYGAVPYHPGAVKYFAEKGITVQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K9</accession>
    <name>D4M9K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA primase (Bacterial type)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_15450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15450"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.804"/>
    <dbReference type="HOGENOM" id="CLU_183799_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-966-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="4">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="82" mass="9342" checksum="FBA7D5E7CA853711" modified="2010-05-18" version="1">MANDDVQLVKEKLDIVDIVGDRVRLRRAGRDFVGLCPFHNEKTPSFHVSQERQNYHCFGCGKGGDVFTFVMETEGLDFPRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9N2</accession>
    <name>D4M9N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage baseplate assembly protein W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_15900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15900"/>
    <dbReference type="HOGENOM" id="CLU_133204_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-989-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="120" mass="13432" checksum="900032E0BFAA47CC" modified="2010-05-18" version="1">MVMQTGMSRAPSDGRFTVLEPLDHIRQSILDIVSTPVGTRVMRPEYGSRVPRLVDQPVTKGWKLSVYTAVAEALHRWEPRVRVDRVRIDAVGPGVVELAILYRLQDGTTNEANVKVGRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R4</accession>
    <name>D4M9R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_16340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16340"/>
    <dbReference type="HOGENOM" id="CLU_000445_21_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1021-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025991">
        <property type="entry name" value="Chemoreceptor_zinc-bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13682">
        <property type="entry name" value="CZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="80"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="463" mass="50026" checksum="96DA46A5E519A6CB" modified="2010-05-18" version="1">MFFGGSNGKKKDEGVRMTPDELRELEAFIAALRRGDFESEAPEFEDPRLRNLSAALGGLLCAHADEYLKMTQDINDVLLSATKASEVLAGLAEKYQKISAGVREDLRTVDELTSDVSGMSSMISRTAEQTTQGGATMEQAKTDIHALAAGNQAAGENLQAMTESMRHLSDSMADIDNLVNIINGIAVQTNLLSLNASIEAARAGDAGRGFAVVAENVRQLAEESKRSVAQIGDHLNGIRTDVMTLGEKFAQLSDGYAKNTESIDKTTEDADGLTGVFGDIGEAMNGLAPVAEKQAASFEGISASLHDTVENIQAVNEDTRGCNDAIFNSLRKINDMRAGLLKYDLPLQSNDIIDLAKTDHMLWLARVNQMMWGNLDPDPDAAADYANCRLGKWYAGEGRKRYGSTQPYRDLGGCHERFHRACADAIRAYSSGKKEKASAMVPGIISLSKEVLRALDAIKALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S9</accession>
    <name>D4M9S9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_16610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.931"/>
    <dbReference type="HOGENOM" id="CLU_087829_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1036-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="171" mass="17913" checksum="379B810F05387877" modified="2010-05-18" version="1">MTTLALRSSSEGATRNLGRLLGRALRPGVAVLLRGDLGAGKTVLVRGVGDELGAKGVRSPSFTLVNEYRTPALLLVHADLYRLDAGGADALGLEEYAGLPDAALLVEWPDRWSFPPREDVLDVRIEALDEGTRRLSLSAAGAGAEGVLRALAEAARTGCPGVEAAGWEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9U1</accession>
    <name>D4M9U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16950"/>
    <dbReference type="HOGENOM" id="CLU_1934957_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1047-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="130" mass="14183" checksum="F28670601A689EB8" modified="2010-05-18" version="1">MTALQAMGLHLAVASNREDPRPTMEQSGTARYFKRLIGARRPDGGRRPFKPAPDMLLELMGDFSATASETLYVGDSDLDIRSALAAGVRGVGITRGNFTREQFETLGAWRVIDSLMELPDLVRAENGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W4</accession>
    <name>D4M9W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonucleoside-triphosphate reductase class III catalytic subunit</fullName>
            <ecNumber evidence="5">1.17.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_17350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.4.2" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1000"/>
    <dbReference type="HOGENOM" id="CLU_002707_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1072-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="772" mass="85642" checksum="C2734B8122962923" modified="2010-05-18" version="1">MFARIRKRDGREVPFNAEKIAGAIGRALAAVGEPGTEAMPLTERVVAHMEQKLQGGVPQVEEIQDIVEEVLIESGRARAAKAYILYRASRSRAREMKSHLMNVYEALTFRDAQDSDLKRENANIDGDTAMGTMLRYGSEGAKHFNEIFILRPEHAEAHHSGDVHIHDMDFLTLTTTCCQIGLKRLFKGGFGTGHGTLREPSGIRSAAALACIALQANQNDQHGGQSIPAFDCDMAPYVARTFARAYRRNLLRALSLLAGEAAEDGAVAALDGLEGGPIRMGATDERQSREREALLKLGVPQEAVERAQEAALREARQDVERETYQAMEALVHNLNTMHSRAGAQVPFSSLNYGTDTSPEGRMVTRNLLLATEAGLGHGETPIFPVSIFKVKEGVNFNPEDPNGDLFQLACRVSAKRLFPNFAFIDAPFNLSYYRPGNPDTEIAYMGCRTRVIGNVADRDRETVTGRGNLSFTSLNLPRLAILSEGDLDEFYRRLDAMADLVVQQLLDRLEIQSRKRVKNFPFLMGQGVWLDSETLGWNDEVRPVLRHGTLSLGFIGLAECLKSLTGAHHGEDPRAQELGLEIVRRLRRRMDAASEANGLNFTLLATPAEGLSGRFLRLDRERFGVIPGITDRGYYTNSFHVPVYHRLNAFEKIRLEAPYHALTNAGHITYIEMDGDPSRNLAAFEKVVRAMKEAGIGYGAINHPLDRDPVCGYTGVIDDVCPGCGRREEGRPFERIRRITGYLVGTLERFNDAKRAEEHDRVKHAGPEPCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X7</accession>
    <name>D4M9X7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate lyase acyl carrier protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Citrate lyase gamma chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">citD</name>
        <name evidence="5" type="ORF">SY1_17630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Covalent carrier of the coenzyme of citrate lyase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomer with a subunit composition of (alpha,beta,gamma)6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitD family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1028"/>
    <dbReference type="HOGENOM" id="CLU_158489_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00805">
        <property type="entry name" value="CitD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006495">
        <property type="entry name" value="CitD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023439">
        <property type="entry name" value="Mal_deCO2ase/Cit_lyase_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06857">
        <property type="entry name" value="ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002736">
        <property type="entry name" value="Citrt_lyas_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01608">
        <property type="entry name" value="citD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-(phosphoribosyl dephospho-coenzyme A)serine" evidence="3 4">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002736-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="102" mass="10955" checksum="DC3826893186DFCA" modified="2010-05-18" version="1">MELKTTGVAGTLESSDVMVTLEPADSGGIKLLLESTVLKQYGRQIRETTLATLERLGVRNAGVTVNDHGALDCTIKARIECAYYRGCGCGPDDRIPWGGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9X9</accession>
    <name>D4M9X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Citrate lyase alpha chain</fullName>
            <shortName evidence="1">Citrase alpha chain</shortName>
            <ecNumber evidence="1">2.8.3.10</ecNumber>
            <ecNumber evidence="1">4.1.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrate (pro-3S)-lyase alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Citrate CoA-transferase subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + citrate = (3S)-citryl-CoA + acetate</text>
            <dbReference type="Rhea" id="RHEA:19405"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57321"/>
            <dbReference type="EC" id="2.8.3.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>citrate = acetate + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:10760"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="4.1.3.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.8.3.10" evidence="1"/>
    <dbReference type="EC" id="4.1.3.6" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17650"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1030"/>
    <dbReference type="HOGENOM" id="CLU_046521_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1087-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009346">
        <property type="term" value="C:ATP-independent citrate lyase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008815">
        <property type="term" value="F:citrate (pro-3S)-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008814">
        <property type="term" value="F:citrate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006472">
        <property type="entry name" value="Citrate_lyase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40596">
        <property type="entry name" value="PTHR40596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04223">
        <property type="entry name" value="CitF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009451">
        <property type="entry name" value="Citrt_lyas_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01584">
        <property type="entry name" value="citF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="518" mass="55844" checksum="A5F1BB6F755D2DC1" modified="2010-05-18" version="1">MKNAVGREIPDELLKEGWKVYQGAGHRDGELLKKRGPRTRIGEKPQGSKLVGSLREAIQRCGLRDGMTISFHHHFRDGDYVANLVMKEVAELGIRDVTIAASSLGAAHDPIARYIEEGIVTGLQTSGIRGRMGEVVSQGRLRTPAILRSHGGRVRAIEEGEVHIDVAFIGAPTSDECGNARAVGGRSDCGVLSYAMADAEYADRVVVVTDTLVPYPNFPASIHGIDVDYVVKVDEIGDPKKIATAAARMTQNPRDLMMAETAAKVMAATPWFKDGFSFQTGAGGPSLAVNRFIEPLMRERGIRMRWAIGGITGSICELMDKGLVDAILDTQDFDVAAIEHIGKSPHHFEISASEYANPANKGALINKLDFVVLAALEVDTDFNVNVITGSDGVLRGAPGGHPDTAASARCCIIVTPLTRGRMPTVCESVVTVTTPGDCVDVLVTDYGTAVNPARQDIVECLDKAGIRHVPIKALQEKAYALVGRPDPLRWKDRVVAILEARDGSILDVVREVMPYEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y8</accession>
    <name>D4M9Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17820"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1050"/>
    <dbReference type="HOGENOM" id="CLU_030671_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1096-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="242" mass="27305" checksum="9E76A025C50B6970" modified="2010-05-18" version="1">MNFNQKWKIIDLSQEIYEGMPVFGMHQKTFFMVNQTHEQNMKDTGSKTLGFSARNMLISEHGPTHSDAVWEFKPDGPTIEKMALELFYGDAICVDLRHVRYPDYIEVKDIEEALEKHGLDIRKGDIFLMYTGHYERTYPDRGYGGITAKHSGVSYEAAKWLAEKGVVNIGVDSPAIDQTPDDLDFSGHLVCGEFGITNTENLCNLDKVVGKRFIYMGLPLRIRAGSGSPIRAVALVEREPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA06</accession>
    <name>D4MA06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Predicted branched-chain amino acid permease (Azaleucine resistance)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_18410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18410"/>
    <dbReference type="HOGENOM" id="CLU_065777_4_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1114-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="230" mass="24738" checksum="EB007C7934F6EE0C" modified="2010-05-18" version="1">MTNEDRGAARRALSDTLPVVAGYIVLGAGFGVLLSTRGYGALWALAMGLVVYSGSMQFVDLELMAGGASLPTTALTALMVSARHLFYGISMVDRYRGAGWRKPYLIYALTDETWSLACSAEDQPGFRRYCFLVSLFNHAAWLTGTTLGALLGPFIPFDTKGIDFALTALFVTLCVEQQLTARRRSPALVGLASSLVCLAAFGPDHFLIPTMLSISAALLLLRGRLEEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA39</accession>
    <name>D4MA39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_18930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18930"/>
    <dbReference type="HOGENOM" id="CLU_1729565_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1147-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="141" mass="15403" checksum="C18BF0D942DA51FE" modified="2010-05-18" version="1">MAINVTKTLSERIQAHEAPIMKRKFPQFALFQGDPSLPFASNGELFWGGTLTTNFGSSFSVAVVYPASYPHGQTKVFVRELMGVRTPHKYVDGHLCLYSNDHGGGGEGIGTETTAAALLGWAAAWLNAWEVYQRSGNWPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA40</accession>
    <name>D4MA40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GIY-YIG catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_18940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18940"/>
    <dbReference type="HOGENOM" id="CLU_2180004_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1148-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="109" mass="11922" checksum="0FB76CC11CBEA36D" modified="2010-05-18" version="1">MGNSVIGPGRMRETDRVRGADCDTPNAPGVYRIRDKATGEIVYIGQTGDVRTRLQQHERSGRFDPETQKASYGIARDGASAQELCDTEKLHIARHRPSGNKTAGGNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA52</accession>
    <name>D4MA52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein (Cas_APE2256)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19090"/>
    <dbReference type="HOGENOM" id="CLU_375867_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1160-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013442">
        <property type="entry name" value="SSO1393-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09651">
        <property type="entry name" value="Cas_APE2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_APE2256" evidence="1">
        <location>
            <begin position="91"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="738" mass="83302" checksum="25192BF71AB7211E" modified="2010-05-18" version="1">MGARTVDKKHVRMICTVGTSFNYRCNDGKNLLWDNKNNEKLLQESEGGLDSPLCELMRTGAMGNPRRLKAIELLDSQALPQTFDEFTFPTAEIQTLVHWLKDNREQIETLHVVLLPSEDVPSRLTAHAARIYLNAAQHLFPTRIQCGLEDILPTKIEVADREKFLRSVAVLFEEFDRQVDQKGPEQPVFCTSGGYKSIVAFAVMYAQLHSIPCLYTFENGPQAFELMHIPLGYAIGTLDEEISLLKAIGSRKGQTGEDLESNLGVPQWVSDTRPLAPMLIKSYERGRRQPCGTGAALFDRLRNAGDRGRRLAQHLERLLAENWAELWMGDQIPETVEHSRRHSKRLMEFASNLFRCAGPQMEALLSLGEDPEKPELLALLIASIYLHDIGHTALSFPVRPTPGRCTPFPLGLFPSAVREVHHLLTGELLRQYPERFFGEEHDCDPFRFLKLCVPFLSEHHRGYTALMDGDGKPSELIGSVGKLLYGEEKFKETLRPLKVRFEEALGNVDLPFTADGILKATALLRVIDGCDVQSDRVISREYLRARLDRTQDEAKFLSAQLEAFALPQQIAQPFSDLKQATSRLDVKQVLEGTFVDEDEVIKTSCRAIYLGVFQALDALRQKHPSAEDRAKGDWGKIQTEEALSFAGLSLANRVAFKWEQFLHFYKHQSVGFVLPVRDSDKEVSVRLYPVDATMCNENTAKIMESIEQDIEGEYKKAKSVLEEHLILKARTSTEGSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA84</accession>
    <name>D4MA84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19500"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1214"/>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1193-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="451" mass="48110" checksum="0ADA9507C5AE3D7D" modified="2010-05-18" version="1">MKETRGVDLTEGSVGKRLLLYFLPILASSLFQQLYTTVDAVILGQFAGKTGLAAIDAVYSFLKLPVNFFVGLSAGTTILISQFFGARDHSSLSRAVHTGIGFALAGGLVLSVLGFLAAPLCLKAMEVPRELFDGSLSYVRILFGGFALSMLYNVGAGILRAVGDSRTPFYVLIAAGGANVVLDLVLVAIFKMNAPGAALATVCAQGLSAALVLRVLLRTRAPYRVSGAELRVDKAMLHSICRIGLPVGLQSALYPVANMMVQSGINRTGTDNIAAWALCGKLDFLIWLIADSLSEAVATFVAQNHGAGKYARTRFGVRVGLFMTVGFIALVSAALFFGSVSLGRLLINPADLDIAFEAGKIMHFLAPLYCLYAIGEVYAGAIRGTGETFKPMLITLLGTCATRILWILFVVPRHPGFYTILGCYPVSWAVTAVAFLLYYQAHKRRAPALCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA5</accession>
    <name>D4MAA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19950"/>
    <dbReference type="HOGENOM" id="CLU_2381963_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1214-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="94" mass="11008" checksum="B230F2E9E440AC30" modified="2010-05-18" version="1">MELKSIENLVDRLAERIETLIEERDDLRREVDRLNACVAERDEECVRVRQEMARTIEEAADESAHVERSGTEIEAKLQTLNDRLIELVMEQQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD5</accession>
    <name>D4MAD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FOG: TPR repeat, SEL1 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20630"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1322"/>
    <dbReference type="HOGENOM" id="CLU_336735_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1243-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="473"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="846" mass="91052" checksum="279D9D27513C9B24" modified="2010-05-18" version="1">MTSPEKFVELCKYGSVQQVREAIQTGICIDAKNQNNRTALMAAAEENLDPEIINMLLQAGADVNAKDEDGNTSLILAATRNSNPKVVDTLIQASADTETKDNYGGTALIMAAMKNINPEIVKVLLHAGADVNAKDKRDKTALMHAAMNSTPEIIKILLFSGADIEARDQYGKTALMYAARDGTLGALKVLLEAGADVHARDENDSTVLMAAVQWLFIDKRPEIAEIVNLLIQSGSDVNARDKDGNTALKMAANSKELEVVNLLLEAGADVNARDKDGAMALHSAAFNGTPGVIKALLEAGADVNAKVEKSFNIGMTPLLYARSSRAVEVLLKAGADIEARDGSGSTALVFAAREGRLGLMKTLLDAGANPDVRDSYGDTLLTVAADSAPNPKIIKALVDIGMDVEARNNDGMTALMMAARWNSLRIVKTLLEVGANANAKLEASTTAMTTDTADGDIFAAIINNKTTDVPVSAGTTVLMLAALNSRKPDVVKALLDAGLDVNARDEEGHTALMLAARWNTSRIVDTLLDAGADIDIRDTDGRRAADYAQENKNLKSRYVQTRLGAEAGGIRQSDEGSGKDVAPMMQFIKKMLRKEGSDRSATESYRKAANEGDAEAARKLGLLYHEGDGVRRNYKQAAEWFRRAMEGGDASAPRYLGLMYANGNGVGKDYAKAAECFRIAGERGDAWGQYNLGVLYYGGEGVKQDYGKAVEWYCKAVEQGLASAEFNLGLMYEQGCGVARDYAKAAELYRRAAEQGDAAAQCNLGFFYSKGWGVKQNNIEAEKWYHKAAEQGDATAQCNLGLMYEKGKGVEQNHEEAIKWYRKAARLGNPDAQARLELINKTKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE0</accession>
    <name>D4MAE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2249 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20720"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1331"/>
    <dbReference type="HOGENOM" id="CLU_1218512_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1248-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018720">
        <property type="entry name" value="DUF2249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10006">
        <property type="entry name" value="DUF2249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2249" evidence="1">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="228" mass="25713" checksum="A03CABCDE32E0699" modified="2010-05-18" version="1">MSFADWKDKRTGFRRIDVRGVAGNFFPGLKKQAMELPVGAGLEVVQTFEPIPLYAVMEQLGFEHHTERATENEFHAWFYRVEVRGEDGTIPMRPAALTNFPLIDEELGRVAVNFWDLTWNDAKRTLPYETRLLLSLANAVGAGRMRQACRELVKAYAQGVDSAALGDVFELLAWNQGIGFFSSEIGPSTLFQAYKTIRQQEKLGKSREEIGALLLERFGEKNPEVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAF9</accession>
    <name>D4MAF9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_20990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="6 7">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1357"/>
    <dbReference type="HOGENOM" id="CLU_128747_3_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1267-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="52" mass="5582" checksum="B89289AD0B8AF1DF" modified="2010-05-18" version="1">MKKYVCKVCGYVYDPEAGDPDNGVAPGTAFEDLPEGWVCPLCAVGKDEFEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG3</accession>
    <name>D4MAG3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ORF">SY1_21030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21030"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1362"/>
    <dbReference type="HOGENOM" id="CLU_038561_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1271-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="78"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL28858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="283" mass="32423" checksum="4BEE7AD2186E4D06" modified="2010-05-18" version="1">MSSIWSDARTFLDIFIVSLIIYRLLVLIVGTRAVQLLKGVLILVLFSALASMLRFRLVSWLIGQSLWALSFAIPIVFQPELRKMLEEIGRGNLWQRQLPRDVAEQRVRHIMGALGYMKLHRIGALLVLQEETGLGEYYNTAVHLDANITQELIISIFWKDNPLHDGALIMNRYSLIAGGCYLPLIDAPEISRWYGTRHRAALGLSEISDAIVLVVSEERGEISLAFKGRLSKNLKDAQVEKLLMHYFVGEPTFRSWRDRLQSFQQLLWDPSTRQLHEDHGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAH9</accession>
    <name>D4MAH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein SY1_21320</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_21320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21320"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1392"/>
    <dbReference type="HOGENOM" id="CLU_140930_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1288-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="103" mass="10947" checksum="B5757D3340377D5C" modified="2010-05-18" version="1">MKLNNIMKQAQKMQAQMMQIQEKLAEETVEASVGGGMVKAVFTGSGDLVGIHIDPEVIKPDDREMLEDLVTAAVNEGLKQSKELAAQRMGSVTGALGAMGLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ1</accession>
    <name>D4MAJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ORF">SY1_21620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21620"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1415"/>
    <dbReference type="HOGENOM" id="CLU_007383_18_0_0"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="312" mass="34580" checksum="52BD0FB9E2C7E17E" modified="2010-05-18" version="1">MDRNARIYVAGHGGLVGSALVRRLTSAGFRNLLLRSHGELDLLSQQTVQDFFEGERPEYVFMAAARVGGIHANAVYPADFISENLMMETNVIRESWRTGVKKLLFLGSSCIYPKFAPQPIPEDALLSGPLEPTNDCYALAKIAGIRMCQAYNQQYGTNFISVMPTNLYGPGDNFGLENSHVLPAMIRKVHEAKAKGAESVTLWGTGTPRREFLHVDDLADACLFLMERHDGSRIVNVGTGEDLTICELAEKVCAVVGYAGRVLWDESRPDGTPRKLLDITFLRGMGWRHTIDLDEGIRRTYQAFLKGGVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ7</accession>
    <name>D4MAJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dioxygenases related to 2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_21710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1425"/>
    <dbReference type="HOGENOM" id="CLU_038732_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1306-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="337" mass="35729" checksum="50298754EE4244EF" modified="2010-05-18" version="1">MGVGISGAGLAGSVAKCGAVGTIASVGLCHNSPLFSVAKHNYFEANAIVIKETLARARELAGADGVLAVNCMVALTDYDTQVRAAAEGGANIIISGAGLPLRLPDYTKDFPDVALVPIVSSAKAASLIVRHWEKKYGRTPDAFVVEEPATAGGHLGATTMEQVYDPVLSLGVAVPEVVKYVAEEMRSDVPVIAAGGIWDRSDLERVFALGAKGVQMGTRFACTEEGDASPRFKQAYIDATADDVVLIHSPAGLPGRAIKNPFVAGYLEGHVESKPCMANCLTHCRYRKTRETFCIAAALVDAFNGDWENGLFFCGSNVTKVHKLEKVRDIISELFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK6</accession>
    <name>D4MAK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_21840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21840"/>
    <dbReference type="HOGENOM" id="CLU_989564_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1315-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="281" mass="30194" checksum="B8759F1A45BF89AC" modified="2010-05-18" version="1">MIPCVWYVSKTVDVWRRALIGRMAESLRSRGVPLSLYVDGSVAGIDARDVSAWSALTGLERASRILFSGRALWHLWGDAPAWWRIVRLRARAVHTSFDEKTSWCGYPSRLFPDRARDGESLILPAFDFRISGVDDEGPLPVVCLGDAAGQGLEDALSGNEHPVVGTDDLSPDAPTARSGVFIAGPQPFDALRAASLTMQGLVAAAIESPHLNALLGSEGYVRAAEDTEEAWRLALEAALSERGRAVAVSARHFIKARCSPERSADSLVALYSSALGGSVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK8</accession>
    <name>D4MAK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_21880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21880"/>
    <dbReference type="HOGENOM" id="CLU_021264_0_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1317-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="33"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="221" mass="25186" checksum="308490B90629ACEF" modified="2010-05-18" version="1">MLCALTLFLCIEWGPLSMERRRWGIASGDPFVKEIALTFDDGPREHGMQELMAALKEQDVHATFFLVGKFAERYSGITLSLSRAGHELENHSYTHPRLYTLWIEKIMREAERCDEVFENLNLPRSRFLRPPGGAFNLKVFNAMRRMNLRLGLWNVNTADYTGKPAQDIVRLVTENAKPGAIVLMHSGVPNTVAALPQIVETLRLRGYRFVRLSELWDGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAP4</accession>
    <name>D4MAP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIID/LytB domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_22470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22470"/>
    <dbReference type="HOGENOM" id="CLU_021203_3_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1355-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoIID" evidence="2">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="491" mass="51876" checksum="B79F98B52FDF6401" modified="2010-05-18" version="1">MTGYAARGGGRVPPGILRLWGLLALLLLAPLATGAEARDIYVRLSAAGSYTVASDGAMTLVDGGGKAYPLGNPAALRVSGGRLLSGKTAFALPVRITGGGLMRFNNRRYRGAFLITSRGLLNVLDLEDYLRGVLPAEVGASWPMEALRVQAIISRTYALRQSMARSSRGYDVTDTVADQVYRGAGVETAATNQAVASTEREILTYGSDLAFTPFHSDSGGHTANNADVWGRALPYLAGVPEPVAYASPNASWSVRIPRGSIEAALARIKAGVGALSEVRVARVDKGGRATALTFTGSRGTSSVRASQFRTAIGPNLLKSTMLTSRAGTPPVAPQQQPKTPQESRPAPVDGRPLPPVPTSRDPMTFAQEKRLAQMTADGVFTTSELVDMLSNPNKKKGYFYIGLQRTGGSAPAPQPARKPVPVVPAAPVAPVTGAGGFTVAREGDVFVFCGRGWGHGVGLSQWGSLTLAKNGWKGERILMHYYPGTEVKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR3</accession>
    <name>D4MAR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative virion core protein (Lumpy skin disease virus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_22760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22760"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1521"/>
    <dbReference type="HOGENOM" id="CLU_037108_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1374-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Band_7_1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="4">
        <location>
            <begin position="323"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="5">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="404" mass="44018" checksum="EC684F62CD9E6968" modified="2010-05-18" version="1">MALLQIVQWNEKIDSGDVFAWRWTDARDPVRSNELGNWTQLIVQETQEAILFRDGQALDLFGPGRYTLSTENVPILRHLINLPTGGESPFKAWVWFINKVNVLDVKWGTQTPILLRDPEYQVPLPVRAYGQFGIRVKESRQFLLKLAGTRVQITREDLVNSFRGLLLSRIGDMIATYISQKKITIFDINAYLQDMSDEATEALRPAFDEYGIESVNFFFGSINVPDDDEAVKDLKRAMSERARMDLKGYSYQQERSFDVLEATAQNTGDGGGGSLMAAGVGLGAGMGLGGAIGQMAAQMGQYVTQGTQPASPPVASAASEASCPRCGKPCPPASSFCPACGARLAEEENQAPASTRNCPKCGKPCAEDGKFCPHCGLPLSCPNCGTRLEAASKFCPECGKSLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR7</accession>
    <name>D4MAR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_22800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22800"/>
    <dbReference type="HOGENOM" id="CLU_986106_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1378-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061573" evidence="2">
        <location>
            <begin position="29"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="282" mass="30735" checksum="B66DD39198CB6109" modified="2010-05-18" version="1">MRRSFRKSAALVAASVCLVFFGASSSGASFVYPGPCPASPVGVAVWPFSQGGAVIAAYQQPYAMNFEVWKPMGLPAGWYATFDGFPVAQAAQNRWVYGQLGPDGALVPTCILVGSVVPGQVPGLTRIAATGLCGRYVNDPEFCKIMNYRCDRMGIIGDPMARTVVAWRSGSEGAWVWLGDRWKKITPQAGEYTWQALKRRRQWIGGELRRNCIGWLCPETCDLADLARQWGLLWGGEVRFDALGGYRGGNGAENGNRRSLPATRAPETPEKKPDNGGHWDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR8</accession>
    <name>D4MAR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_22810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22810"/>
    <dbReference type="HOGENOM" id="CLU_2011909_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1379-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="123" mass="14122" checksum="763B12F81AED94FA" modified="2010-05-18" version="1">MLRVDREMSGFQGSTRTPSGAGEVVETKGFASVEDALKQVEEARARTSEATFRAWDRHTDMVEKSQKLRRIRMRQEAIKRRNQEQRENSRELMAQVALQNANRTKMIEAGAMKRKAQERNAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAR9</accession>
    <name>D4MAR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22820"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1527"/>
    <dbReference type="HOGENOM" id="CLU_065947_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1380-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="44"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="261" mass="29411" checksum="6822A0A9124692B4" modified="2010-05-18" version="1">METVRCFLDPVRGDRGSAVRFTADLSGGPGGSFSGTLHRAPRRRTVRLIVDERGLTVLVPRLFRPERDLEGLLERNLDWILRGLSRLLPRPRDAGRGPVALPGVVRLPALSEEWRVEVVEAGCASASEGVIPLASGLGRTEALRALREWVRLRARQTLPPMLLELAAEQGLVVARVLVKEMRSRWGSCSVRHNVNLNSRLLFLSPDLVRHVMLHELCHMAEMNHSPAFYARLRSMDPETDRHRQELRSAWSRLPPWASEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAU9</accession>
    <name>D4MAU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAP-type C4-dicarboxylate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_23370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1578"/>
    <dbReference type="HOGENOM" id="CLU_768936_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1410-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="360" mass="41471" checksum="6516C81368CCDC12" modified="2010-05-18" version="1">MWNVRVLRKVLAGVVFLMVLHAAAVFAEPEYKWRFGQTSVRASQGKSYRLFCDLIKKYSDGRIEVEFFPDNQLGTLDEIFHAVQDGEVQMCGFAPYVNLVPGGMFNWMPWTVESWEECKMAFSRPDGCLFVPLEEAMKEVGVHILFTVSQGSYGIGNRVRPIRTPEDFKALKMRVSSSLGCVRGLQNMAEGTGMTVETVPWGDLYNALSRGVVDGCWDMWPSLVEERHCEVMKYYTSLDWMWDANQVVINRELWDSLPGDLKAAIQKAADEAEADQYRIQEEEEAKFKAFLEKLPDFEIYYPTEEERALFRERAKNLENWQELCAPWLDKHFPGQNMTQRILDALAENREKVLAGKKMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAV1</accession>
    <name>D4MAV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_23390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23390"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1581"/>
    <dbReference type="HOGENOM" id="CLU_102849_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1412-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="167" mass="19632" checksum="D3FDBA340C726381" modified="2010-05-18" version="1">MEFRDRQYDVFNMFDKQWGLATAGTLEDFDGCTIGWGSLGSLWGLRSDGRLIVTIYVNPLRYTSEYLLKSDCFTVSFFEEKYRRDLLTLGTKSKRDCDKFTMTSLTPERHGEGVVFSEATLTFVCRKLYWEQFDPAHIDPEVMREIYSDRPPHYQFIGEIMEVLDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW3</accession>
    <name>D4MAW3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="1">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">birA</name>
        <name evidence="3" type="ORF">SY1_23560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23560"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1597"/>
    <dbReference type="HOGENOM" id="CLU_051096_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="67"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="1">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL29008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="331" mass="35953" checksum="CD67B9871AFF8871" modified="2010-05-18" version="1">MIKSDVLRMLEERRGTAISGEAMAQALGVSRAAVCKAVASLRAEGHLVGSAPRRGYLLERESDVLTEEGIRSHLSEACGVRRVVCLDTVDSTNTHAKRLALAGAESGTLIAANQQTVGRGRRGRSFLSPAGTGLYMTLLLRPSSSMERFQMITIAAGTAVCLAVEELTPLRPLVKWVNDVYLHGRDGVERKVCGILSEAVSDVESGTVENVVVGIGLNVTTRDFGRDLNDRAGSIFPEGVSRNQLAARIAERLMDFSTRLEDPELLRAYRERSLLLGRRVRWMQDGRGCLGRAVDVDELGGLVVEDEDGARRSLRSGEVYEVRPFDGAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW6</accession>
    <name>D4MAW6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="16" type="ORF">SY1_23610</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1602"/>
    <dbReference type="HOGENOM" id="CLU_000524_4_3_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="13">
        <location>
            <begin position="29"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="294"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="14">
        <location>
            <begin position="451"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="15">
        <location>
            <begin position="530"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="10">
        <location>
            <begin position="657"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBL29011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1222" mass="136722" checksum="0DC7E421B7789F51" modified="2010-05-18" version="1">MPEFVPVSRTRQRYTFGRAHDLIDMPDMIEVQRDSYQWFYQDDVEPDARRAQGLQELLQEIFPIESYDGQFSLEFVRYYIDPPERSEEEARQKDLTWSRPIRATIGLTNTKTGESKEKDIFLGEFPVMTDRGTFIVNGTERVVINQLARSAGVYFTYSGVPGSDSCSAKLIPDRGAWLDFSMASGDIVSVNIDNRRKLPVTLLLKAFGVADNDEILSMFAAAPYFMEYSDEMRGKLAAEDVTGPDGAAIVRRGRPITRELLDELYHKNPGGRGGIEVIGLDLSLALTLERDGTRSPDEAMQEIFRRLRPNEPARVENARDYIRSLFFDSRRYTLGRVGRYKLNRRLGMNLSEDVRLLTLDDIVAIIREMFAMRAEGKKSDDIDHLGNRRIRSIGELLQNQIRIGLLRMERIVRERMTTTPDLNKVTPPDLINVRPIAAALREFYGSGQLSQFMDQTNPLAEVTHRRRLSALGPGGLSRERAGFEARDVHYTHYGRVCPIETPEGPNIGLVSSLTTYARLNEHGFLITPRRKVTNGKLTDKIEFLSADEEDQYYVAMANTPLEEDGVTIAGDSCPTRHQDDIDTIPVEKVNYMDVSPKQIVSPSTALIPFLEHDDANRALMGSNMQRQAVPLIMPEAPMVGTGIEHRVARDSGSCVVAVDAGEVVYVDSREIRIRSRRGERKYPLIKFRRSNQGTVIHQRPTVAKGDRVDKGEIIADGQSIENGELALGQNVLVAFVPWEGYNFEDAILLSENLVKEDKFSSIHIEEYEIDARETKLGPEEITRDIPNVGEDMLRNLDDSGIIRIGAEVNAGDILVGKVTPKGESDQTPEEKLLRAIFGEKAREVRDNSLKLPHGSRGKVVAIKHMERNDAPNTMSAGIIRTVKVYVAQWRKITVGDKMAGRHGNKGVVSRILPVEDMPYLPDGTPVDVVLNPLGVPSRMNLGQVLETIMGFVAVNNGWHVATPVFEGAQETEIFERMKELADEKYPDLTEDGMIVLRDGRTGEPMEKKVTIGCMYMLKLNHLVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEGYGAANVLQEMLTVKSDDIRGRDKTYERIVKGQSLVKPGMPESFRVLVKELQGLGLDVEVEYDDGTIGGIPLDEDEEKLPEPGLPEMLPDAFEDESPADADGQGAQEQESGFLEDEEPDEGELFKAQDIFEEDADMPKDDPDDSLAGDISLISDEEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX0</accession>
    <name>D4MAX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ORF">SY1_23680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1608"/>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="31"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="287"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL29015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="428" mass="46435" checksum="E50306C039D0CE29" modified="2010-05-18" version="1">MAHLLWGGADCVELARSFGTPLYVLDEAVIRARCAEVRRDFLSRWPGTDACYASKAFVTRAMARIVDQEGLGLDVVSLGELRTALSAGFPPERIELHGNAKSEVELRTALEVGVGRIVVDSLMELDVLADLAEEMGPAGADPAARRAGGFRQHARLHRHGRVGSKFGLPLEGDLLFEAVRRGMARSGLDLLGLHFHVGSQLFEPDAHLRSLVRVLEAAAELRARLGFELRELNFGGGYGARSNPSESHVPIALFTDAMMGALERECATRGLKRPVASIEAGRWIVSEAGITLYRVEVVKELPGLTYVAVDGGMADNPRRPLYGAVYEAVSAERPDAVADRSGSRVSVVGRCCESGDVLIEDARLPALRRGEVLAVFNTGAYTFSMASNYNRLCRPAVVLVRDGRADLIVRRETPEDLLAGDEIPDRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ0</accession>
    <name>D4MAZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_24050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24050"/>
    <dbReference type="HOGENOM" id="CLU_2093271_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1452-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL29035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="116" mass="12767" checksum="334797229F4A35E1" modified="2010-05-18" version="1">MSEGFFCPFRGHVCLPEINGETAAVVSWTCQQCGKIHLADAVSESEDTGMLIFFTVKAALFPAVSTGPIIRQWAGVHFPYLALFLVKNFVFSEAWVGHNVTVTMIKILDIGFQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M704</accession>
    <name>D4M704_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="3">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="4" type="ORF">SY1_00700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00700"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.104"/>
    <dbReference type="HOGENOM" id="CLU_087476_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="93"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="176" mass="20019" checksum="B049876A69D78104" modified="2010-05-18" version="1">MILSGREIVREMGSGIVIDPFDERRVNPNSYNLSLHGELLVYRDEVLNMKTPNATEALHIPPEGLTLTPGRLYLGRTAEYTRTEKYIPMLEGRSSTGRLGLCIHVTAGFGDIGFAGYWTLEIFCIQPVRIYAGVEICQIYYHTIAGEYDLYKSGKYQNNRGIQPSLMYREFQQDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M729</accession>
    <name>D4M729_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.378"/>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-56-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="182"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="390" mass="41981" checksum="4E7D7AF84F77AE1C" modified="2010-05-18" version="1">MDFISLEKDAIGWRRHIHQHPELGFKEFETTKYIRERLEEFGIADFIPLKETGVAAVIHGASAGPCIAFRADIDALPTAEDSGYPWPSLNPGVCHACGHDVHTAVLLGLSKALQQERTKLAGSVKLIFQPGEEIMCGAESIIRSGVLEDPIPEAIVGLHIWPQTPCGDVAFCHGPMMASSDSFTITVTGKQGHGAHPEVCVDALYIAAQVLIAVQGIVAREVSPTDPSVVTIGTIVGGLAPNITAGEAVMKGTMRCMTLETRSYIKEALERIARQTAIAHKGNATVKFAGPGIPPVISDEKVLREVEIAAQQALGEDHIRELKEPSMGSEDFSLYLKKIPGAFYRLGTALKDNAATHKSLHSPQLFVPDEAIIAGIRVMYQFAVNRLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M733</accession>
    <name>D4M733_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_01120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01120"/>
    <dbReference type="HOGENOM" id="CLU_3414716_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-60-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="27" mass="2852" checksum="6549AB712BD81037" modified="2010-05-18" version="1">MTQACKEADKDAPVIMGSPTSPVWSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4M745</accession>
    <name>D4M745_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">SY1_01320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01320"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.556"/>
    <dbReference type="HOGENOM" id="CLU_061495_2_0_0"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="234" mass="26863" checksum="4B89149D8A204ECA" modified="2010-05-18" version="1">MEKREQLYEGKAKKVFATDDPKRYVVEYKDDATAFNGEKRGTIAGKGVVNNRMSNILFRMLEANGVPTHFVEELSDRETLVRAVEIVPLEVIVRNVAAGSFSKRYGVEEGRVLRNPTLEFSLKDDSLGDPLINDSHILALGLATEEELRTMHEMAFKVNDLLKDYFLKIGVKLIDFKIELGRCDGRIVLADEISPDTCRFWDARTNEKLDKDRFRRDLGHVEDAYQEMFKRVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M753</accession>
    <name>D4M753_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_01450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
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    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|651822.3.peg.662"/>
    <dbReference type="HOGENOM" id="CLU_045224_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-80-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
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        <property type="entry name" value="Na_H_antiporter"/>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
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            <end position="50"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="433" mass="46510" checksum="0D1EFB0A8379B3FA" modified="2010-05-18" version="1">MIFNLNPLWGFLPLLLYIILMLMGKDMNVSVLLCVILGAVLNGESIMGFANTIKNSLGSFCAMIGFIIVLGSGLAEVLSRTRVAHNLVYTVVSRFKLKNKKMAILISMATSTLMVSLLGTLAGSNAIIAPILIPIVASVGLTPSTLGVILHGAGATGLYIGPFVPPVVTIMGLTKITYGSFMMNAGIPLAIIVWGSTFFMACWTQRRTEGKETYAETDKEATSFVPDERCKRATWVFLIVMAIMIVYGLYIGAGASYAILVMMAASIIVGMVGGLSLKDSLTTMITGGSKMFWMFFMFVLFDPFLNYVSASGAFNAVAELMKPLIDVGGKVAFLMLSAAVGVFGISGTGVAQAQITHELFLPMVNSMNIEMAIWSLIVLVACQITFFVTPTVDMVGQMGLARSKNIKAMLANGWVLTIITFGYVLVRAILYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D4M757</accession>
    <name>D4M757_9BACT</name>
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        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
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                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
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                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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    </comment>
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            <end position="375"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBL27702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="418" mass="44662" checksum="3A35AABE11FBBC51" modified="2010-05-18" version="1">MRVGGKKVSLTTQVFLAMILGSIAGLVDGKTMVQLGFLGDIWLNCIKMIVVPMVLCTIVTGIVSQDSLTSLRRVSVRIIAYYVVTTVLACIVGIVVAMLLQPGKFADFAGLATQEVKGGVDITLADFLKGLFSTNMVKTFADGNIVQTLVIAILLGIAILRIANQEHKEVMRKFFNGFNSMIFSLIGMIMSVSPIGVFFLMGSSFGKYGAGIFTSMAVLVGTYYAACLAHVIIVYGGFLMAFKPHINPLRFIRDSAEVWVYTISTCSSIATIPVNIKVAEEKFGIPERISGFTIPLGSQMNTDGSVLLYACVILFISQMIGQQMTLLQLINVIFISTILSMGGGGIPGSGIVKLMVVVQSAGLPLEVVGVIAAFYRLFDMGTTTNNCLGDLVGTVIVGKAEERYAMAENGDGASSQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M764</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="135"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
            <end position="369"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="419" mass="47495" checksum="AE2BF12975F60B89" modified="2010-05-18" version="1">MEYIKRAVEDIALHSDKTFKSLLVTGARQTGKTEMIRKLFPDKKYVLIDDPFVEDQANNNPNLFMMLNQPPVVYDEVQRAPGLFRYIKIACDGTDDKGLFCLSGSQPLELMEKASESLSGRIGIIEMSPLSQREIDGDAFNAPFLPTMEYVRERNKTAKAPNNLWERIHRGGYPALQDPEIDWGVFFSSYVKTYLERDVRKLSAVQDLNDFRRFMVAVAARTGQRVNYSNIADEIGKDQTTVKSWMSILEASGIVYLLEPYTPGVLRRAIKTPKAYFRDTGLAAYLTRWLTPETLANGAMSGAFFETFVISEILKSYSNRAIDYRYCVSYYRGRDRKKVKKNGAMIEIEGEIDLIIEENGVLHPIEIKQSSSVAADETSAFLVLDKVNEKRRGAGAVICNCPQPGMLRENVLQIPVWFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4M768</accession>
    <name>D4M768_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Beta-lactamase class C and other penicillin binding proteins</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">SY1_01640</name>
    </gene>
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                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_01640"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.736"/>
    <dbReference type="HOGENOM" id="CLU_020027_15_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-94-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061496" evidence="1">
        <location>
            <begin position="26"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="462" mass="50794" checksum="3CA7563D4085736A" modified="2010-05-18" version="1">MSKYLLAVLAVVLAGTVGGGFPALAAPLDAERTAGLDAALDAMIGSEGTCVPGLGVIVYKDGTRAYSKFLGRRHIDAQDPSLDRPFTEDSRFRVASVSKQFTALAVLQLTEQGKLDLDADVSQYLGFSLRNPHFPDTPITLRMLLSHTSSIRDGRAYAIPPQYGVKEFFVADGKFYEEGTHFAPAEEAPGKYFRYSNLNYGLLGTIVEAVTGERFDRYMRAHLLAQLDIKGSFNPGDFTKEELALLGSIYQKQKDGQWDEKGPWVAQIDDYGDEAPDRDTVAVNNPDIRETDSWYGLADYKPGTNATVFSPQGGLRVSCAELEHLLQLYLNDGVYNGVQVVRKDLLDEMFRVQWQFDPDHPNGNTYGGSIEAYCLGVYPLLGTGRSRPAKDLDVNLKGHLGEAYGLLSGVMVRTGTRDGFIYIMNGEAVAEDDDPRSEGTFSGNYIWEETMMNAICSNAFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7A1</accession>
    <name>D4M7A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_02200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02200"/>
    <dbReference type="HOGENOM" id="CLU_155837_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-129-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL27746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="84" mass="9900" checksum="FA46E7D75F98030A" modified="2010-05-18" version="1">MFTIDTAPATQVRERFKDYCDDVERTNKALIVTRRDKPQVVVVSFAEYNRQLNNERYLAKLRRSREELDNGEGQTMTPEELDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C2</accession>
    <name>D4M7C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02460"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1703"/>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-152-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="188"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="392" mass="41770" checksum="0B2D8270FFA6BD62" modified="2010-05-18" version="1">MNLWEECKGLQDYIVGIRRTLHQIPELGTDLPKTQAAICAELDKLGIPYKKNVGDSGLIGTIQGGKPGKTILLRADIDALPIQEDTGLPFASKHEGRMHACGHDTHAAMLLGALRVLNEHRAELAGNVKFVFQTGEEVCKGAKVAVKEGVMDGVDAVFGMHIGSIFEGMPLGSFAIAPGCIMASFDRFVLTVKGTGCHGSTPEKGVDPITIASNIVLSLQEVIAREIAAPKAAVLTIGKIAGGFAYNVIPNEVVIEGTIRAFEDPVRQHLAKRIGEIGKGVAATFRGGCDFEMDWGAPPVVNDDAMAKLAAEAAAKALGRENVVTAFNPVMGGEDFAYYLEKAPGAFMALCSVNPEKHADAPHHNPKFDVDEDVLYRGSVVFVSIVEEFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C9</accession>
    <name>D4M7C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Protein GrpE</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">HSP-70 cofactor</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Heat-inducible transcription repressor HrcA</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">grpE</name>
        <name evidence="7" type="synonym">hrcA</name>
        <name evidence="11" type="ORF">SY1_02540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GrpE family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02540"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1712"/>
    <dbReference type="HOGENOM" id="CLU_454744_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-159-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 7 11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="10">
        <location>
            <begin position="104"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL27774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="600" mass="66703" checksum="3D306FB9817AC28B" modified="2010-05-18" version="1">MTERQLSIILAVVYEYIKTGEPAGSRTITKKYIKGLSPATIRNEMADLEEMGYFYQPHTSSGRLPTAKAYRVYVDSVTARARSRSSRGAEAWRRELMGRRSGIEDLLNYVTNLLSRLTNCVAVAAVSGLDSMEIWHIDLMPLGGKNVLALIVLKGGLVHHTEFTLPCEVEPGLLEELSRRINTIACEHSWSEVHDVLYQYVLGGLEEAETACRAAISDVDRFLTEQNYRFFSSGAKHILSLPHFQALSRLQAVLTLLEQEKPLASMVEQCRQASDLRVSLGDENETDGMQESAMILIPARACQQKAVLGLIGPLRMDYERSISVLEAVADALDDEAGEPGRLRKEEALNAQEKNKRAGRKGLPTRMSRNAGDDRTAEREMSAMTEERLKEDYLIPEAEDALGDSEAEAMSRPVKEYSIGEDGVLIEETPEPEEKAKGKEKEEGAAHPPAKEPDEGAEERVAELERQLAVARADFYNYRQRAMRERQDLRRRAMEDLIVSLLPVLDNLDRALSVPEDGSAKDILAGVKMVSRQFLSVLDEMGVSAIPAKGERFDPALHEAIGAVPVEDAEEDGAVVDEQLRGYRTKDRVLRPARVLVGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D0</accession>
    <name>D4M7D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="10" type="ORF">SY1_02550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02550"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1713"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL27775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="612" mass="65676" checksum="D8D6BC583BC27602" modified="2010-05-18" version="1">MSKVVGIDLGTTNSCIAVQEGDQTTIIPNNEGARTTPSVVAFTKDGERLVGQLAKRQAIVNADRTIMSIKREMGHDYHVEIDGKKYTPQEISAMILQKLKRDAEDYLGEKVTQAVITVPAYFTDAQRQATKDAGTIAGLEVLRIINEPTAACLAYGENRKEEHKILVFDLGGGTFDVSILDVGEGVFEVLATAGDNRLGGDDWDNRIVDWMVSEFKKTEGVDLKNDSMAMQRLREAAEKAKIELSNMTETTISLPFITATQAGPKHMEMKLTRAKFEEMTADLLDRTAVPTQRALSDSGLDPSKVDKVLLVGGSTRMPMVQKKIVEIMGKEPTKGINPDECVAAGAAIQGSILTGDHKDIVLVDVTPLSLGLETLGGVFTKVIERNTAIPVSKSQVFTTAANNQAQVEIMVLQGERSMAADNVKLGQFVLDGIPPAPRGIPQIEVTFNIDVNGILNVSAKDKGTGKSQKITIQSSNLSKDEIERMKNDAETHADEDAKKRSAAEVRNEADSAVFGAEKLINDYGDKMTAEEKGKLNSQIDDLKQAIDKKDEAAMRRAKEALEGTVQAFSTRLYQAAGAGAEGAAAENDAGGAGAGGGDGETVDAEFSDKGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7D8</accession>
    <name>D4M7D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1746"/>
    <dbReference type="HOGENOM" id="CLU_030408_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-168-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061145" evidence="1">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="311" mass="33852" checksum="F840252CB97E6C4F" modified="2010-05-18" version="1">MALKTAQKKLKRILTCLLPALAAAFFTVGAEAVQTCPPRVVIDFEYAEARDFHEGLAAVKSNDAWGYIDSLGRMVLPFVYRVPEAGPFSEGVAFVGDRYIDPDGKPVFGDATFEGGLPFSQGFAAVQHGGLWGFIDMTGRFAIAPSFEAAGSFSQGLAPVRRNGLWGYVDAAGHMKIPPQFLSAGPFSEGLAPVEVEGRFGYIDVAGRDRIRASFDEAGPFKYGLAPVKRHASYRAWGYIDARGRLVIPHRYNGALPFSEGVAGTATDARWSFVNVLGENVLNNQYDEVRPFSEGLAAVRQEDLWGYIRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F4</accession>
    <name>D4M7F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_02890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1768"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-184-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="294" mass="33910" checksum="4783FA40A708DB01" modified="2010-05-18" version="1">MKRFAAGMLWLLPLLILLGLFTVWPALRTVDMSFYTRYNYFRDLVFERGLDNYAYLWNDPEFWRSLDNTFFYTAWTLPLSVGIGLALALALNAIGPFKRLFQTIYFLPFVTSTVAIALVWNWIFHLDHGLLNAMLQGVGLDPIPWLRDPRWARVSLVILGVWKSAGYNVLIFLTGLQTIDAQYNRSAAVDGAGFWRRTFFITLPLLSPTLFFVCVISAINCFKVFDLPFILFRSTPGPSNCGMTLVYYIYEKFYNQHHYGIASAAVLLLFGFITLFNLIQFRLARRVIHYGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7F8</accession>
    <name>D4M7F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02950"/>
    <dbReference type="HOGENOM" id="CLU_3356349_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-188-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="36" mass="3989" checksum="AE9015CF434CEFE0" modified="2010-05-18" version="1">MLGSWTLDSFIIGSVILFAVPIIACIHRQIQQGKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7G3</accession>
    <name>D4M7G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_03010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03010"/>
    <dbReference type="HOGENOM" id="CLU_3412571_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-193-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="28" mass="3245" checksum="1212FB0ABF2E2800" modified="2010-05-18" version="1">MLREGMSPEIVARFTRLPLDEVEALKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7I1</accession>
    <name>D4M7I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_03360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03360"/>
    <dbReference type="HOGENOM" id="CLU_182236_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-211-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="81" mass="9598" checksum="9C9B1B8AF6CEA08D" modified="2010-05-18" version="1">MKQFLRFLNRLEEEKIYYRLNKVREEAVMAEIAVPGERWEVEFMEDGSVEVERFVSTDGVSGCADMDHCPELDDLFERFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7I9</accession>
    <name>D4M7I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ORF">SY1_03530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03530"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1836"/>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL27834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="479" mass="54062" checksum="0539B0E35A6BD011" modified="2010-05-18" version="1">MARNITARSVDYSQWYLDVIKAAELADYAPVRGCMVIRPTGYSIWENVQRYFDDAFKRTGHVNAYFPLLIPNSFLQKEAEHVEGFAPECAMVTHAGGEELEEPFAVRPTSETVIGHMYSRWIQSWRDLPVLINQWCNVMRWEKRPRLFLRTSEFLWQEGHTAHATEQEAREETLRMLEVYRKVMEEELALPVITGEKTAGERFPGAVATYTCEAMMSDAKALQAGTSHFLGQNFARAFEIRFQDRDGELATCWTTSWGISTRLIGAIIMTHSDDDGLVLPPHIAPVKVVLLPISKDERQAEGVLLPMARELSGQLDEALGGLYTAVDTQFHMRPGDRFFTHLQRGVPLRLELGEKDVQSGTVRVVRRDTGEKADLSRDALVPAVQKLLEDVQSNLYRRALSFREAHTAQASSYDELKAILAERGGFVEAYFGGTPEDERRIREETGGVTPRCIPLVDASTGRCIVTGKEGRRTIFAKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K7</accession>
    <name>D4M7K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_03870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03870"/>
    <dbReference type="HOGENOM" id="CLU_2915847_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-237-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="61" mass="6806" checksum="20EA82338D40B804" modified="2010-05-18" version="1">MKKRLTIALASVLYLWIMNALTVNWLGEPCSAGFDCVHPRVKGYAAPTFTAMLYKTVSVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L1</accession>
    <name>D4M7L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03920"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1870"/>
    <dbReference type="HOGENOM" id="CLU_022794_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-241-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061735" evidence="1">
        <location>
            <begin position="23"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="547" mass="58926" checksum="9B2E149BD82A9A27" modified="2010-05-18" version="1">MKTMQLKGLLFFVLAYGVLASAGCGGGDSEEQGISGPAPNPYLSAPLYGTTHFDPAQSDSTPYGPPKGSFTIDPVRQPISYGGPVNIITLASTSPRFMWGVGSDRVAYINAAEKQWAEVARLDAPAYLSPDMGPVAPGAHKTIGEMSFEGKTSRDIHQVFVTNYGAKYNARLANGVYSVVDKDNVLYATYGYGVYAFALKDAANPAAGIEVRHSIADAADAIQGAGARAVLYGLNMTYDGHIILNFENGVSVLNRTLDAASAQTILFPGEHTSNSLAVDEKGGIYVVTNKRMHKLVWTGSRLSDAEADGAWSSPYDAPEDAVPPIVKFEPGSGSTPTLMGFGKNADRLVVITDGSRRMNLVAFWRDEIPQDFVQQDGTQSRRIAGQIPVTCGYSQLPTWIQSEQSVVVSGYGAFVVNNLPLESDTMARLPKILGAATLGPVYPSSRGVERFRWDPKEHRWASVWRRSDVSSTSMIPVHCRNGNMALVSGYGAQGWELTGMDWDTGATVHRTIFGKSNYGNGAYAILQFLPNGDLLFNSLVGPYRVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7L5</accession>
    <name>D4M7L5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ORF">SY1_03980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03980"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1878"/>
    <dbReference type="HOGENOM" id="CLU_113663_8_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="67" mass="7647" checksum="31C6F2EFA458ECE8" modified="2010-05-18" version="1">MTKEAVNSIPGVAFLREVRAELKKVTWPTKKQVWYWTLIVIVFTLGVSLYLGLIDFLLTWAFSGMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7N1</accession>
    <name>D4M7N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (VWF) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04220"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1909"/>
    <dbReference type="HOGENOM" id="CLU_080398_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-262-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="221" mass="24832" checksum="7C3240FDD813B70F" modified="2010-05-18" version="1">MKENLTEIVFVLDRSGSMSGLESDTIGGFNAMIEKQRKGDGEALISTVLFNDQSEVLHDRADVKDVRPLTEAEYSVGGSTALLDAIGGAIHHIGNVHRYARPEDVPERTLFVITTDGQENASRRYGLRKVRQMIELEKSRYGWEFLFLGANIDAIETAERFGIGRDRAANYCSDSEGTRLNYDVMSEAISTVRLRQPLSADWKRRIDEDCRRRSGRKGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7P5</accession>
    <name>D4M7P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable proton-coupled thiamine transporter YuaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04450"/>
    <dbReference type="HOGENOM" id="CLU_090959_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-276-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015234">
        <property type="term" value="F:thiamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012651">
        <property type="entry name" value="Thia_Transptr_ThiT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09515">
        <property type="entry name" value="Thia_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02357">
        <property type="entry name" value="ECF_ThiT_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="181" mass="18932" checksum="5A1410A917721EE1" modified="2010-05-18" version="1">MSNSNAASIRSATAAMVEGALCIALAVVLSKVNLFALPNGGSVDAGLAPLFIFAWRRGLRWGVAAGALAGVVKVLLGGYIVHPVQVVLEYPLAYAMTGLAAAFSCKKPLGQAMGLVLGFLAQTGCHVVAGAIFFAQYAPKGQNPWVYSLLYNAPTLGAKYLLSAVAAWLLWKALERALPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q4</accession>
    <name>D4M7Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type metal ion transport system, periplasmic component/surface antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_04680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1961"/>
    <dbReference type="HOGENOM" id="CLU_067080_3_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-285-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061829" evidence="5">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="276" mass="30105" checksum="2AF5223C53C10B72" modified="2010-05-18" version="1">MKKAFFAAAVLALALTGTATAAQTVRLGLVGGIYEDFWAPAKEELAKEGIDLEFVPFTDYVTPNRALSDGDIELNAFQHDIYLQNEIKEYGYKLTNIGGTFIEAMNIFSRKVKSVSEIKDGDTVAIPNDVTNGGRALKVLAASGLITLKESAGFSPTVADVEKYNVKVEIKEMAANIIPAALPDVTAAVINGNYAMDFGFKLEDAIFRDTSLNEKPYWNLVAARTADLEDPAKVELYGKVMKAFRSEATKAVLDKMFGGYVVCAGWDEDFLAPFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Q7</accession>
    <name>D4M7Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SprA-related family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_04750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_04750"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1968"/>
    <dbReference type="HOGENOM" id="CLU_902073_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-288-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021973">
        <property type="entry name" value="SprA-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12118">
        <property type="entry name" value="SprA-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="317" mass="32950" checksum="20DA51967CF1E541" modified="2010-05-18" version="1">MNVTSMLSSGYLEPVIREPSSDKLRDDRWLGAQGAVRSSAAGEGSLALQERSVLDQERALKAAAGGNAEVYTVYHYTVGADGRRYITGASVTMKGQEADLNRAGNGLATQEIQPGVPQEAGAAEADETAEAPEAQPRTDAKSAEERQKDAQVQELKQIEREVIAHEAAHMVAAGALGGGVSYTYTAGPDGKRYITGGEVPIQIQQGATPEETLRNMQQVQRAALAPADPSGQDRQVAARAAAMAAQARSEIASEGARKAARRTDATQEEAPSKAETVARGTPVPPPEAAEPDPSKAGAAAVVASVRAADVMGQRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7T3</accession>
    <name>D4M7T3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_05150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="T03.001"/>
    <dbReference type="KEGG" id="sbr:SY1_05150"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2010"/>
    <dbReference type="HOGENOM" id="CLU_014813_0_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-315-MON"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061513" description="Glutathione hydrolase proenzyme" evidence="6">
        <location>
            <begin position="28"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="568" mass="60886" checksum="44846395AD23CE68" modified="2010-05-18" version="1">MKVLRSRKLAIAAAALFLVSGASGALAAPRNELLIGNGNGMAVSTQPLADKAGQDVLDRGGNAIDAAVAVGYALAVVHPQAGNVGGGGFAVIHTADGGDYALDFREMAPGAATRDMYLDKDGNVIPQESTRTYKAVGIPGTVAGMSAMLERFGTMKLDQLIAPAIEMAEKGYELSERQAKSMADFADKFRKFPHSQGYFLHGDGTPYRAGELFQQADLAATLKRIAAEGPKGFYEGKTADLIEADMKANDGLITKEDLKRYEVKWREPSTADYRGYKIVSMCPPSSGGAIVAEILNVVENADMRALGCHTPAALHVMAEAMRQAYADRSEYMGDPDFMKVPVEELTSKAYAKKIYDRIDPKGATPSSEVRPGLEPLKEGTNTTHYSVVDKMGNAVAVTYTINESWGTGAAVKGAGFLLNNEMDDFSAKPGVPNVYGLVGGDANAIEPYKRPLSSMSPSIVSRDGKTVLVVGSPGGSRIITTTLQVIQNVIDYDMPLNEAVSAPRFHMQWLPDELRIEHDNGLSASDVEALTEMGYKLSLKPYMGDVNAIHIDLRTGKITGSHDSRMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U8</accession>
    <name>D4M7U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05340"/>
    <dbReference type="HOGENOM" id="CLU_2861265_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-330-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="64" mass="7507" checksum="839FE84B50658575" modified="2010-05-18" version="1">MQVIQQTRTSVNVSGYVDRLEHGIVRKHLEVQLEHVKEPVYVQRPIIDDLNSQVIVHDQVEQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V3</accession>
    <name>D4M7V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05400"/>
    <dbReference type="HOGENOM" id="CLU_041900_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-335-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="2">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="82"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="242" mass="27778" checksum="6DBB0B9668BDF48D" modified="2010-05-18" version="1">MAKVPRVHCDSCGVCLVPVPWAREGSGFTLLFEALVLSLAPAMPIKTLAKELNMHDTRLWRVIRHYTEQALERRDLSGVRNVGFDETASKRGHDYVSVFVDLDTSKVIFATEGKDSSTLGRFKTFLEKHGGRGENIERMCCDMSQAFIKGAREHFPGAKLTFDKFHVVKVVNDAVDSVRREERKEDPSLAHTRYLWLKNPQTLTEKQKAWLGELSLRKHNRKTARACQMKLGFQDIFRRFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7V6</accession>
    <name>D4M7V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_05430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05430"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2034"/>
    <dbReference type="HOGENOM" id="CLU_079430_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-338-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL27951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="150" mass="16387" checksum="EC0AAE28B2E5B720" modified="2010-05-18" version="1">MKLTDRIAADLMAAMKAREERRLSSLRMLKTELQKLAADKGRGAEIADEDVHTVIRRLIKQRKEAAEQYAAGGARDRAEAELAEAAVLEPYLPAQLEDAALDEMVRQAAQDTGASGPRDMGRLMKAVLALAAGRADGARVKDRVTAYLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X1</accession>
    <name>D4M7X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase components of various ABC-type transport systems, contain duplicated ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_05650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05650"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2058"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-353-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="311" mass="34649" checksum="36309AB824658AAA" modified="2010-05-18" version="1">MSALLEVEDLRQHFRVSRHFVVRAVDGVSFHIDRGETFGLVGESGSGKSTIGRTIIRLYAPTSGRVVLDGTDISGRLSAAALRRLRTQVQMIFQDPMACLNPRKKVINIVAEGLDIHRLYGSSRERREKVYDALETVGLSAEHANRYPHQFSGGQRQRIGIARALVMEPSLIIADEPITALDVSIQAQVVNLLKEVQQRTGVSYLFIAHDLSMVKYISNRIGVMHQGRLLETGTPTEIFSRPIHPYTRSLLSAIPLPNPVKEKKRHAVDYDRRAEGIEYAQGTLHDAGGAHRVLATDAEFERWRALSPNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7X7</accession>
    <name>D4M7X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05790"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2070"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-359-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061741" evidence="1">
        <location>
            <begin position="26"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="72"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="503" mass="55420" checksum="7BBE732D9ADA125D" modified="2010-05-18" version="1">MKRFHSALLIAALVLSLSQPVALSAAENKDTLTWAQGADVTSLDPHIGKETPAIMATNQIFDTLFTTDDEGKIVGQIAESWKYLSDTELEVHVRSGIKFHDGSPLSASDVKFSLDRAIASTAVSYIVNFIKEVRVVDDHTVVIETAKPYAAALRNLAHPSSAIVPEAYVKADEARFRLNPIGSGPYRFVSWKQGDSLKLEAFDEYYAGAPKTKNLVMKVVPEAAQRTIALETGEVDIANDIQANDQQKVRDNPDLTLNEKAGLSCWYLSFNMKKKPFDNKLVRQAIRHAIDVNTIIDSIMYGGGEPAGDLIAPGVFGYAGDKPYAYDVELARKLLAEAGYPDGFSCKLWVNDSQTRIEVCQAVQAMLLEVGIKCEVEVMEFGSFIERTSKGEHDMAYFGWTTSTADADYTYYSLVYSTQTGAPGNRSFIQDPRVDELVDLGRGNTDETIRRKAYADLEQILQDLSNNAPLVYSTLNSGTSKKVHGFVLDPAGYHKLENVTVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7Z7</accession>
    <name>D4M7Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0065 (bug) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06120"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2099"/>
    <dbReference type="HOGENOM" id="CLU_045683_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-379-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017082">
        <property type="entry name" value="YflP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061834" evidence="2">
        <location>
            <begin position="24"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="316" mass="33838" checksum="62B6FC6A305A3EB0" modified="2010-05-18" version="1">MKKAFSALLTALLLTGMASASFAADWPTKPINVYVTHAPGGDTDYMARQLSAQLEKVLGVSVVVSNVTGANGATCMQQYKDGSKDGYTFIATNTAALNGNEATQMVDFGYSAFEPVAVYGIQSGENIVVPADSPYKDLKELIDASIANPGQIRFGISTGGGVYIMACVLTNLGHAQFNIIDAGDGANRLTALLGKAIDATSLPYSTAADYIEKGQLRSLCTVLSKAPTLLPDQPSASAVIPELKLDTEYVILAPKGTPADLVKSMNDAILKVCGSEQWKKLVNDYCYQDPFFFNVEDTVQNLKEQRDLFQSFLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M801</accession>
    <name>D4M801_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripartite ATP-independent periplasmic transporter solute receptor, DctP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06180"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2104"/>
    <dbReference type="HOGENOM" id="CLU_036176_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-383-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061173" evidence="2">
        <location>
            <begin position="26"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="329" mass="36079" checksum="BEB1819BFD1A154D" modified="2010-05-18" version="1">MIRWKFSTVILAIAFMTAVCPATEAADAIHLTLAHADTPEGSLFGTCMTEFKNVLEQRSNGSIIVDIFPNGQLGTVSEYVVGVQSGTIDLAPAASTFIANFCHTVSIFDLPFLFEDYEHVWQTLDGEVGTQLTSALADNGIEALAWWGLGFRNVTTSKKHPINSIGDLKGFRIRTMQSAIHQALFQALGADAVPMDWGELYTALQQGTVDGEENPFTQVLSSNIWEVNPIIVKTEHAFTPAVFMMSPQVASKVSSEQLELIRNCAKECTPIFRKATVDINADALKTLIQEKECSFIETISKADLQAATASVYNSYPEYADLVQSIRNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M819</accession>
    <name>D4M819_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06440"/>
    <dbReference type="HOGENOM" id="CLU_059362_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-401-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061008" evidence="1">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="221" mass="23284" checksum="AB80E05049D6C5D9" modified="2010-05-18" version="1">MFAAFRKFCAFLLAVAVLLPTGAASADVPLPAPQRTGGPGVFDAIGSRASALGADFASMGEVSSEKLSTILWAATGLNRGEKGWTVPMAMGMEPYVKVYVARADGVFLYDWKAHALKEVSGEDVRGRIGKQDFVAKAPCTLILVSDSEALSRKFKDEDAEEQFAAVAAGAMAQDVYLAAGAVGVGTRYIRSVQKDAVEDVLGLRDDDDVLCIMPMGTKPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M824</accession>
    <name>D4M824_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_06500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06500"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2138"/>
    <dbReference type="HOGENOM" id="CLU_1155099_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-406-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="240" mass="26852" checksum="4E19C6B7E9AEE114" modified="2010-05-18" version="1">MLTKAKCPACGGALELNPGLERGICVYCGSEFLVREAIQKFKAEVDGLPTLQNMLIRAEQKLFDGDQEGAEALYEKILEGAPTCHEAWWGMFKVKFLRNDFTFYEGTIGRTRAMIENLGSSREALRAIEYAPDDVKVFYSGEIERIKRKWEADLAPHEAREAALARRRAEQRKEDEEKEKEKENTMKGIGRIMVVGIVLSLLVVASTDSSVGTGIDSPACWGAFSFWGCLLGWGLTVMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M872</accession>
    <name>D4M872_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="8" type="ORF">SY1_07310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07310"/>
    <dbReference type="HOGENOM" id="CLU_160655_3_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="91" mass="10383" checksum="119CDC4D36DFA4C3" modified="2010-05-18" version="1">MPNKQSAKRRVRIEERNRLYNRYWTTRCKTAVKKLLESVEAGDGEAAARNFNLAQSVLDKAVVKGVMHRNTASRRKKLMARAVKGLSRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M874</accession>
    <name>D4M874_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase subunit C</fullName>
            <ecNumber evidence="7">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_07350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2223"/>
    <dbReference type="HOGENOM" id="CLU_126047_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-457-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="160" mass="16508" checksum="380132C1F63B7BE8" modified="2010-05-18" version="1">MEYLGLSLALLGAALAAALSGIGSAIGIGIAGESAAGVMTEDPNKFSKCLILQALPGTQGIYGLLIMFFVLIKLGLLGDAGAVTLNWNQGLQVFASCMPIAIVGWISAIYQGKTSAASIQMISKKPEAMGKAIILPAMVETYAVLALLTSIMMLNFGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8A2</accession>
    <name>D4M8A2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Triphosphoribosyl-dephospho-CoA synthase</fullName>
            <ecNumber evidence="2">2.4.2.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_07780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine</text>
            <dbReference type="Rhea" id="RHEA:15117"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61378"/>
            <dbReference type="EC" id="2.4.2.52"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.2.52" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07780"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2270"/>
    <dbReference type="HOGENOM" id="CLU_056179_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-487-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30201">
        <property type="entry name" value="PTHR30201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="294" mass="30867" checksum="29FF628722189DAB" modified="2010-05-18" version="1">MNDILVFNIARLAVKSMLNAGAAWPKPGLVTPLADAAGTAFQTIVEGALGLLPCFINCASIGLETEAMNPEDVMTLLRPAGMQGEREVQGVVRGRTSFKGSIFFLGLFSAAAGRLFAQERNLTPLALALTASSCVRGLVERELRGLDEGSAELTPGERAWTLYGVDGARGEAERGFPVVVQAVDLLRQLEEGDDSPSGRESAAQALLGILAGNSDSALAERAGLDGMLRVQAEAKAALLAGGVLTSEGRKAVDALDRRLREADVSPRGAEVALAAALFVRDLEALRPTRSGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8D6</accession>
    <name>D4M8D6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Flagellar biosynthetic protein FliQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fliQ</name>
        <name evidence="10" type="ORF">SY1_08250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08250"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.24"/>
    <dbReference type="HOGENOM" id="CLU_164516_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-525-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006305">
        <property type="entry name" value="FliQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01402">
        <property type="entry name" value="fliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="91" mass="10174" checksum="BFC15BBC9FD57EEA" modified="2010-05-18" version="1">MAETALSLFDLLSQSIWTMLVVSLPVLLVAMSVGLLIGILQTATSIQEQTLIFIPKILAVFICIILLSPWMGQRMLVMTREILGQLERFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8F4</accession>
    <name>D4M8F4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_08580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08580"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.54"/>
    <dbReference type="HOGENOM" id="CLU_074407_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-547-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="100" mass="11093" checksum="C534DB5395FE96DC" modified="2010-05-18" version="1">MLGNMAASLFLSGQVRTTVTRAKELRRVAEKLITRARGGSVHDIRVVFSRMPHKEAATKLFKEVAPRYMSFDKGGYTRIVKLGVRAGDGSEMAVVQLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G8</accession>
    <name>D4M8G8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">SY1_08760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08760"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.73"/>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="122" mass="13353" checksum="D243FB01D56B5DA1" modified="2010-05-18" version="1">MIQLTTVLNVADNSGARKLFCIQVMGGSKRKWGTIGDVIVASVREAIPNSNIAKGSVVKAVIVRTRKEVRRRDGSYVRFDDNAAVIIDANGEPKGTRIFGPVGRELRAKKYMRILSLAPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I8</accession>
    <name>D4M8I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_09040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09040"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.108"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-581-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="111"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="313" mass="34673" checksum="56C9AF4B1C9054B4" modified="2010-05-18" version="1">MSSMERAVPDISDPRLFEPVSPEERTRAEFVRPSLSYWQDAWRRLCRDRVAILGLVVILIILAMAVVGPWLSPYTYDGQDFMVSNEPPSLKFWFGTDMFGRDIFVRVLFGARISLAVGFVASFINLFIGVIYGGIAGFVGGRTDNVMMRIVDVIYSVPTMIYVILLMVVVGPGLKSIFITLGISYWASMARIVRAEVMRIKNEEFVLAARVLGASSTRMLLRHLIPNAMGPILVTLTFSIPRAIFTEAFLSFVGLGVSAPMASWGVLSNDAIGSLAIYPWQLFFPAAAISVTILAFNFLGDGLRDALDPRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8I9</accession>
    <name>D4M8I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_09050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09050"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.109"/>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-582-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="305" mass="34142" checksum="E312A1FE04A1359F" modified="2010-05-18" version="1">MRRYIFQRVWASFLTLFVVVTLTFFMMRAIPGGPFTDEKAIPPFILEKIMARYHLNDPLYVQYGHYLWDVLHFDLGPSYRYEGMTVNQLIASGFPASLMVGSIAILLSLVVGIPAGIVSALRRGRWQDRTAMVLATLGITIPNFVIATILVYFFAYRWGWVTVGFWEGLPTALLPAITLAGYPTAFISRLTRSSMLEVLQQDYIRTAYSKGLRERAVVYIHALRNAIIPVVTYLGPLIAGILTGSFVVEQVFGVPGLGTFFVTSISNRDYTTIMGVTIFYSALLVSLNLVVDICLGFIDPRIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8K6</accession>
    <name>D4M8K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NCAIR mutase (PurE)-related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_09440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09440"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.146"/>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-599-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="118"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="251" mass="26124" checksum="931F20474A17BCD0" modified="2010-05-18" version="1">MSLSVRQVLQRVSEGTMSVEDALLHVKEKPFEDLGFAKVDLHRRVRQGAAEVIYGAGKTPEQIVGILEAMRRNGQGPVLITRLSPEAAEAVGRSCALDYHEEPRVGIVGDLPQPDGIGRIIVATGGTSDIPVAEEAALTAEVLGSEVQRLYDVGVAGLHRTLSHLEDIMSASVLIAVAGMEGALASVLGGLAECPVIAVPTSVGYGVSFGGLAALLAMLNSCSSGVTVVNIDNGFGAGYCANRINHMGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8N7</accession>
    <name>D4M8N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_09920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_09920"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.192"/>
    <dbReference type="HOGENOM" id="CLU_086407_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-631-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="181" mass="21485" checksum="DCBF90194B2DAA84" modified="2010-05-18" version="1">MSLKELWQLFPIFLVRHHEEWDDWYAEEKSTLTALLPRETVKRLSHVGSTAVPDIWAKNIVDILLEVGSEEDLNNVEKRLLQKDWLCMSRSAHRVSMNKGYTPSGFAQKVFHLHVRLWGDNDELYFRDYLREFPAVAKAYEALKLSLWRRFEHDRDGYTEAKGDFIKKHTSLARQRYGARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T5</accession>
    <name>D4M8T5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SY1_10840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10840"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.293"/>
    <dbReference type="HOGENOM" id="CLU_013350_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-686-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0410">Iron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="12">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL28280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="843" mass="93268" checksum="0C1930BCD67E994C" modified="2010-05-18" version="1">MGKMNKMGKKIVALAGQPNCGKSTVFNSLTGARQFVANYPGVTVDKMMGWYRRDGESVEVVDLPGTYSLTSYSPEERVSRGVLLGEPLSAVVNVMDAANLKRSLYLTIQLLEMEIPLVLDLNMMDVAENLGITVDAAGLSKELGVPVIGTAITQGRGREDLLRAIADMSRSSARTSLATAELYPDLKDALRELEALLAGASLGETFPLPWIAVKLMEADPEVAALVREKAEGRAQEVLLKAEALREHFEREKGMSADLYVSGQRSRRAAAIAGRHVVKKDAEKVHISERIDRAVCNKFFGPVFLLVVIYGFYYLSFIQGYNLTHYTWPVLAGFRSLAESVLPQPGLIELPLLREFVLWIVDNLNALFNYIPIFFILFALIAVLEDSGYMPRIAFVLDRILSRFGLHGQSTLPMILGGVVLGGCAVPAVMATKGIPDEKSKLATILTLPMLNCQAKLPLYFLLIGIYFNETVRLPLFGEVNQQNIVIVFIQTISLLFVLPIAKILSMTALKHKETAPFIMEMPPYHIPSLRGVLGRAIERIWLYIRKITTVVAAVAVVLFVLLQFPGLTPERKAHYEAEKDRAVQAFLDRAKDKKLGSGLRSEDDVLRLILYQQGYKELLKSGASAEKKKAYGLKNPDFFEIIQNKKDPEAKALEKELKKLVLFRTNTLTAIRRERIDNSLLGKIGRALEPASRYAGFNWRVNVAVLSTLAAKENSVSTLGALYIKEPGEAGGAGKNTDTLEQRMKQQEGDLTPLHAMALMLFMVLCPPCLPTIMAIRVQTGSTRWMLFAFFMPLLLGLLTAVLVFTGGSALGLSGFQAMWMFYLIPLTLTVLLGLIKTKRTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8U2</accession>
    <name>D4M8U2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion-translocating oxidoreductase complex subunit G</fullName>
            <ecNumber evidence="6">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rnf electron transport complex subunit G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnfG</name>
        <name evidence="9" type="ORF">SY1_10950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnfG family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10950"/>
    <dbReference type="HOGENOM" id="CLU_077882_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-693-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00479">
        <property type="entry name" value="RsxG_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006091">
        <property type="entry name" value="E_trnsport_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01947">
        <property type="entry name" value="rnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="8">
        <location>
            <begin position="101"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="200" mass="20506" checksum="6AAF6FE3C06C6621" modified="2010-05-18" version="1">MNAAAEETSLHKALRLGGTLFLVTAVTGLVLGGVERGTRTAILKARMADQADALRNVMPDAETFKAVDVAPEDGTVVVTGAQEALKGDARVGYCLTVSTKGYGGPISMVVGLKEDGSVSAIRILTHAETPGLGARSAEPAFYRQFDGRTALPLKVVKGAAGAGDEISAISGATITSTAVTAGVNAAEDYWSRNLKGGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8W6</accession>
    <name>D4M8W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11330"/>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-717-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="266" mass="29825" checksum="57390E564443DA8C" modified="2010-05-18" version="1">MKLRVGVLQFDVVLGDRTKNRATLQRWLKSALVPSDLTTVLVIPEIWDVGYALPRAKELADPEGKGAAEFLGALARQYGVWFAGGTVLASTPEGFANRGQVVNPRGELVEYYDKVHLIRLMEEDKYFVPGRKECLFDVDGIRAGCVTCYDIRFCEWVRTYALDGVQVLFVGAEWPMSRIDHWEALLRSRAIENQMYVVACNRCGESEDTLFGGRSMILGPKGEVLFQAGAGEEAGFVILDMDEVEKTRGFLTVFNDRVPGIYKVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8X1</accession>
    <name>D4M8X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein (DUF2088)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_11400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11400"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.347"/>
    <dbReference type="HOGENOM" id="CLU_055092_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-722-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="38"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="410" mass="44702" checksum="8FDD109BDA71080C" modified="2010-05-18" version="1">MPVLLDESYRYPLPKMHRVRQHFSRPRLDDLEAQIRREFEKACIADRIKPGARVAVAVGSRGIKNLARIVKEVLVQIQRWGGNPFIVSAMGSHGGGTQEGQLHILNSYGITENAMGIPIITAPDATRVGKTKSGLEVWVDSAALEADLIVPINRVKLHTDFVGDIQSGLCKMLTIGLGNHVGCSALHEASFEGFAETLIEAARIVMARAPVGFGVAILENAYDETAMIEAVPVEDIVEREKELLQTAKGLMPTLMLPDIDVLVVEEIGKDISGAGFDPNVLGRSSLLKKFVLPVPKIKRMILLDVTAPSHGNAIGVGLFDVITRRVLEKLDLPSMYANALAVKAPEDVKIPITAESEEEAVRFALQLARGVDRANLKIVRIKNTLNLETIEVSEALLPCVEGNKKLERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8Z9</accession>
    <name>D4M8Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA-substrate-specific enzyme activase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_11830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11830"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.418"/>
    <dbReference type="HOGENOM" id="CLU_066597_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-752-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="251" mass="26548" checksum="AD072688AF23F1AB" modified="2010-05-18" version="1">MLYAGIDIGSTASKAVVMNDGKDEILARKLMPSGWNGRETAEALLAWLLSLGCRREDLRITATGYGRVSVPYADDTLTEITCHGRGACFLGGEDLTVIDIGGQDTKVILVRGGRVADFIMNDKCSAGTGKFLEIMANRMGVTLPELFELAERGREITISSMCTVFAESEIVSLMGLGTPREDIACGAVGSVVAKVAVQVARKAADDAYFLTGGFCDSAMMLRKLSQALHAPVRTTSDARFAGAIGAALLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D4M902</accession>
    <name>D4M902_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_11890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11890"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.423"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-755-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="226" mass="25517" checksum="023B8C29FA7978ED" modified="2010-05-18" version="1">MIFQFDYFLKMFSIIFLGFKNTVSMAFLSLFFAVLIGFVLAASRYYNIPVLKQFSVVFTSFFRSTPFIAQLFVFYYGFAQVSATVRGLSSFWAVVIVLSLSFAAYMGENIRGAISSVDRGQFEAGISIGMTPWQTIRRIVIPQAARVALPGMVNSFANLFKSTSLAFTVGVMDMTSCAKNEVNLTYRYLEGFVALLIVYWVILALVSYGQSLLERYLNRPYVQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M907</accession>
    <name>D4M907_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_11940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11940"/>
    <dbReference type="HOGENOM" id="CLU_055576_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-760-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="53"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="306"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="411" mass="44802" checksum="2ED4A8261476D19D" modified="2010-05-18" version="1">MVDKIAEERTRKPLTRFRLAYLNVAHSASRTKSLVFLVTLLSFAIFTGGYLSLSLGRGMSSLADRLGADILVIPSGTEGQVQGTILKGNPSKFYMPFSILNDVTATPGVAAASPQLFLATLSAGCCNFAIQLIGFDPETDFNIRPWVTRQLQGTLESCDIVVGANIVAQEGETLMFFGETFRVAARLERTGMGFDSSAFVTVESARHLMGNERFRLNYPEVNDPTTISSVMVRVDEKSDVADVARELCRRLKGSGVTAISSMDVVRGVTEKFKSMRVHALLLSVILWGVSFAVLKLIFTVLMNERKSEFALLRIMGAPRGYLRGLVLTEAFLVSLSGAVLGTALSAFLCVVFNRVLTVSLGMPFLNPSPGQFFLLAIGSLLLALFTGPMAGWSFAQRLNRKETLTLLRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M912</accession>
    <name>D4M912_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type metal ion transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_11990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.434"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-765-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015821">
        <property type="term" value="P:methionine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="274" mass="30671" checksum="645467E5813E04C2" modified="2010-05-18" version="1">MQMITFENVCKSYDGVDVLNNLNLKIADNEAFGIIGPSGVGKSTILNCLNGLEKYQRGSVVVDGVRVETLSDAELRRFRKNVGLIFQNFSLIGRKDVFHNISFPMECWGCSKTEIKDRVEELAEVTGMQEKLKSRPAELSGGQKQRVAIARALALNPRYLLCDECTSALDPRSTASVLELLESLREKYKITIIIVTHEMAVVRRFCERVGIIDGGKASLVGNVAEVFREVPQQLRAVLGDEEGKVSFTIDIHDFESCRKFLDDRGIRYGIAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M914</accession>
    <name>D4M914_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12010"/>
    <dbReference type="HOGENOM" id="CLU_2769893_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-767-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="69" mass="7776" checksum="1CAE05CED7B77912" modified="2010-05-18" version="1">MANFRDSLTFKNYDQERLIIDSIAARLSAEENAFRKTCGEDEEERGTGSFACKVTVENWIGELWRGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4M919</accession>
    <name>D4M919_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_12080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.443"/>
    <dbReference type="HOGENOM" id="CLU_191308_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-772-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="84" mass="9746" checksum="EA992737EBFE1DF5" modified="2010-05-18" version="1">MTKVEFINTCPCCDGHVDVLNELQKRFPEKIDLKIYYAGKDFDYLPKYGPITRGTMIVDGKDRYEDLNRRTIEKVVSEAIGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4M945</accession>
    <name>D4M945_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="9" type="ORF">SY1_12480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.486"/>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="102"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="103"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="309" mass="32975" checksum="3AB75B9EA613EA68" modified="2010-05-18" version="1">MAFFARLKEGLKGVKERWSGGIARLFSGSSFDDAFWEELEDRLIAGDVGVELSEELVESLKGEVRARGIASPEALRDVFVERITAELLSVPGMGKPFETEPAPQVLLMVGVNGSGKTTSAGKLALQFKGQGKGVVLAAADTFRAAAVEQLQIWGERVGVRVVAQGQGSDPAAVAFDAWQAARSAGADLLIVDTAGRLHDKHNLMEELRKIQRVLVREAGEDRVQTVLVLDAVLGQNSVAQAETFNSILPVSSIVLTKYDNTAKGGVVLAIARRLRIPVRCIGLGEAPEDLSPFDPAEFAAALMEGEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M961</accession>
    <name>D4M961_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">SY1_12810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_12810"/>
    <dbReference type="HOGENOM" id="CLU_132074_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-814-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="80" mass="8754" checksum="8182D57EBE8CF945" modified="2010-05-18" version="1">MVNYKELVEFIVRHLVTQPDAISVESGEEESGLKVMIRVAHEDVGRIIGKRGATINAIRLLAKAAAVKAGERVDVDIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M985</accession>
    <name>D4M985_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_13240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13240"/>
    <dbReference type="HOGENOM" id="CLU_3216633_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-841-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="44" mass="4302" checksum="ADF4624B7E78D177" modified="2010-05-18" version="1">MQVARLPGVGIKSCACSGQKESSAANSASSMASSTPAPGCDVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A3</accession>
    <name>D4M9A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
            <ecNumber evidence="3">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_13570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.180" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.590"/>
    <dbReference type="HOGENOM" id="CLU_039592_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-859-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="112"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="250"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="342" mass="37360" checksum="69C929EBE2CDC93B" modified="2010-05-18" version="1">MSALQDTQPGIEAIEYWLPDQVVTNEDLAREFYDWDPQKAWRATGIRERRVGPEPASDMAVQAAEKLFSLHSVDRSSIDFLLLVTQSRDYPMPATACIVQDKLGLPTSCGALDLTLGCSGYVYGLFMAKALLASGSCRRVLLLTVEKISHLHPADRSTRVLLGEGASATLLSASDPIASIGNFDLGTDGRGYANLFVPAGGTALPHSPETARSIADPAGNVRSQDTLFMDGMEIFSFSVREAPKTFRAALEKNGMSKEDVALFVFHQANRMILETLRAKLDIDPSRFCIDLERVGNTSSSSIPIALRDRMDALRPGDNVLLCGFGIGYSWGSTVLKWRRSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9A7</accession>
    <name>D4M9A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar transferases involved in lipopolysaccharide synthesis</fullName>
            <ecNumber evidence="3">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_13610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.594"/>
    <dbReference type="HOGENOM" id="CLU_024920_1_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-863-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bac_transf" evidence="2">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="198" mass="22080" checksum="662EDDC43E34D8D1" modified="2010-05-18" version="1">MLKRLLDVAGAALGLVLLSPVMLAVAVCVRRRMGSPAVFVQTRAGRGGRPFALYKFRSMTDERGPDGNLLPDAERLTPFGRFLRRTSLDELPQLWNVLRGDMSLVGPRPLLTQYVPLYDARQRKRLDVRPGITGWAQVNGRNALSWPAKFELDVWYVEHRSTGLDLKIILLTIKKVLAREGIAASGEATMPPFEGNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E3</accession>
    <name>D4M9E3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">SY1_14430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14430"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.681"/>
    <dbReference type="HOGENOM" id="CLU_038422_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="303" mass="33659" checksum="861C7F22622D1DFF" modified="2010-05-18" version="1">METHEPVLLPEVLSFLSEASEPRRALRIVDGTLGLGGYSEAILRAFPDGRVWGVDRDPDALRLAKGRLSAFAPRFCAVHANFGDIAGVLEGEAPFDAFVFDLGVSNLQLTEAARGFSFQQDGPLDMRMDPGGGAPSAAEVLSGLSADELARIFWEYGDERYSRRIANGIIQRRARGLRLETTGELVTLIREVLPAPVQRKMGTHPARRVFQALRIFVNDELSAIESMLATLPTLAGEGCVAVVVSYHSLEDRIVKHRFRSWEKEKGLGRALTRHPLLPQEEERTRNYRSRSAKLRAFRFFEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9E5</accession>
    <name>D4M9E5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">murD</name>
        <name evidence="11" type="ORF">SY1_14490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14490"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.687"/>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="118"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="120"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="458" mass="49018" checksum="E65F5E5EA2605FD2" modified="2010-05-18" version="1">MDDKVRDFSNWKGKRLTVVGAGVSGRELALLAARIGARVFVTEQKGVSAEVAELFSRNGITWEENGHTGRAFEADAMLLSSGIPPTSEVVLSARKRGTPLIGELDFVIPQLRGRLIGVTGSNGKSTVTALIGHMLNAAHRNVAVGGNLGRAASVFAGREFDAVVLELSSFQLEWTHTLSSCVSIVTNLAPDHLNWHGSYEAYVAAKAKILSLRAPSGWGIVQDRDVEALKAGGEERVITLSWEERPKHGMAGHIFMGEEEATLRLNGEMTPLFRYSETTLLGAHNLENVAMSVAALRLLGLDEDAKTLLKGFFPLPHRCERAGTVDGVLYVDDSKGTNVAASVTAMTALPGRKVVILGGRGKGEDYAALAEGVLREADAAVLLGEERDAIAGALRGAGFTAVTLAQDMEDAVRKAQTLARPGMTVLLSPACTSWDMYENYGQRGDHFCSIVRGLQEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9G7</accession>
    <name>D4M9G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_14840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.12" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_14840"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.743"/>
    <dbReference type="HOGENOM" id="CLU_055968_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-923-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="278" mass="30342" checksum="CE401268B896C639" modified="2010-05-18" version="1">MNVGIVGLGLIGGSMAKSVKTRTLHTVWGADIDRETMTLARLCGAIDGPLTDENLADCDLLLLALAPRSVVGWVQEHAKGISRKTVVIDLCGIKRAVCRELAPLARQHGFTYVGGHPMAGLERSGFVNAQPDLFAGSSMILMRGPDTDIQLLDRLKAFFTDVGFASLTFTTPEEHDRIIAYTSQLAHVVSSAYVRSPEALERRGFSAGSFRDMTRVARLDEILWTELLMDNRDFLVGQIETLIDNLNGYLDALKSDDAARLRALLKEGREKKAQAGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9J0</accession>
    <name>D4M9J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15180"/>
    <dbReference type="HOGENOM" id="CLU_165255_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-947-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="72" mass="7806" checksum="804C67B7B4C8B28E" modified="2010-05-18" version="1">MSETITVDARGLSCPQPVMAAKKALSGLMSGRVEVLVDTGTSRDNVARFGENKGWRAAKEEREGGWKVVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L4</accession>
    <name>D4M9L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ethanolamine utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_15590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15590"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.816"/>
    <dbReference type="HOGENOM" id="CLU_076302_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-971-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009193">
        <property type="entry name" value="EutL_PduB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030984">
        <property type="entry name" value="PduB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012290">
        <property type="entry name" value="EutL_PduB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04501">
        <property type="entry name" value="microcomp_PduB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="3">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="BMC circularly permuted" evidence="3">
        <location>
            <begin position="158"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="268" mass="27629" checksum="F04971EA5BA582DA" modified="2010-05-18" version="1">MDKDMVNQVMDAVMKRLGDTPAPAAPGAEKASAGVEPCFANIGVTEFVGTAQGHTMGAVIANVDPILHQVMGLDPKYRSIGIISDRVGAGPQIMATDEAVKATNTEVLSIELPRDTEGGAGHGCLILLGAEDVSDARRAVEVALSNVQNYFGDVWGNEVGYLELQYTARASYAVNKGLGGPLGKAYGLVLGAPAGIGVVICDTAVKAAEVEVLSYASPSKTSYTNEAFISITGDSGAVRQAIRAARDVGLKLLGAMGSEPKSASVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9L6</accession>
    <name>D4M9L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbon dioxide concentrating mechanism/carboxysome shell protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15700"/>
    <dbReference type="HOGENOM" id="CLU_148498_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-973-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01614">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004992">
        <property type="entry name" value="EutN_CcmL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036677">
        <property type="entry name" value="EutN_CcmL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36539">
        <property type="entry name" value="PTHR36539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03319">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159133">
        <property type="entry name" value="SSF159133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51932">
        <property type="entry name" value="BMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="93" mass="9684" checksum="8F1F6C8EEED59D23" modified="2010-05-18" version="1">MMLGKVVGSIVATRKDERLVGQKLLLVEPLVRRGDGALDGDRDRMLVSVDVVGAGRGETVLLVSGSTARAAVSLPDSPIDACIIGIVDEVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9P9</accession>
    <name>D4M9P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriophage Mu Gam like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16130"/>
    <dbReference type="HOGENOM" id="CLU_129156_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1006-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009951">
        <property type="entry name" value="Host-nuc_inhib_Gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07352">
        <property type="entry name" value="Phage_Mu_Gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="149" mass="17037" checksum="B03077B7CE85D1FA" modified="2010-05-18" version="1">MAREKPKQIIAPIRDLTEADNALAEIAEIDRAVAAANQQLNEDIDALKKNTQDEIAPLLERKSRDLGFGTIGFRKSTSLATLKKICSTWKEVLGKLKEYGFRDAIRVKEEPDKEAMSEWPKERLELVGVQRVEKDEFYYEISQEKLAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q2</accession>
    <name>D4M9Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16160"/>
    <dbReference type="HOGENOM" id="CLU_3080185_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1009-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="52" mass="6030" checksum="C90AAA86507F1072" modified="2010-05-18" version="1">MRCPKCGADKTGVRVTNDLGDSVERIRQCKACRAWFRTLEEEVRRVDAPYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9R8</accession>
    <name>D4M9R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family</fullName>
            <ecNumber evidence="1">1.21.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_16400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.21.4.2" evidence="1"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16400"/>
    <dbReference type="HOGENOM" id="CLU_053106_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1025-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030699">
        <property type="term" value="F:glycine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010187">
        <property type="entry name" value="Various_sel_PB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07355">
        <property type="entry name" value="GRDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01918">
        <property type="entry name" value="various_sel_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="348" mass="37449" checksum="F0CFD59C6EC2CD6A" modified="2010-05-18" version="1">MAFRIVHYINQFYAGIGGEEKADYKPEIREGVVGPGTALKGALGSEAEVVATVICGDSYFASNMEKASADIIEMIKKYKPDAFIAGPAFNAGRYGTACGAMCAAVAKELGIPVVSGMYPENPGVEMYKKALYIVETPDSAVGMKKAVPAMAKLLMKLLKKEPLGKPAEEGYIERGIRKNKFYEKLAAERCVDMFVAKMKGLPFETEYKMPVFDRVPPQPPVKDMKHATIALVTSGGIVPKGNPDHIEASSASHYGTYDITGVMDLTTDKYRTAHGGYDATYADQDADRVLPVDVLRDMEKEGVIGKLYNKFSTTVGNGTAVANAKRFGAEIANKLVADGVTAVILTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9W0</accession>
    <name>D4M9W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17280"/>
    <dbReference type="HOGENOM" id="CLU_3153144_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1067-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="48" mass="5726" checksum="F7F647FACEE002BC" modified="2010-05-18" version="1">MASSRRKYPRRAWMDRSVFPCRLVVVRNPERREWAERSSDSPAAACRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y5</accession>
    <name>D4M9Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas1</name>
        <name evidence="10" type="ORF">SY1_17730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1042"/>
    <dbReference type="HOGENOM" id="CLU_052779_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09722">
        <property type="entry name" value="Cas1_I-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="PTHR43219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03641">
        <property type="entry name" value="cas1_HMARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="336" mass="39119" checksum="2D42EF1F8C49E749" modified="2010-05-18" version="1">MGKTLYLLSSGALRRKDNTLFVERAGEPGQKPRFLPVETTDEIMVLGDLELNKSLLEFLTQKQIILHFFNYHGYYAGTYYPREHMNSGAVILAQAAHCMDGGKRHALASALIVGAIQNMRKVVGYYQRRASLDVQDILEDLERFEDLAPRSEDVPGLMGIEGNARNRYYQFFDRLVQDEAFKMLERTRRPPTNRMNALISFLNSMCYILALSQIYRTHLDPRIGFLHETNFRRFSLNLDIAEIFKPILVDRLIFSLVNKREIQEKHFEKETGGGIYLNDRGREVVLRAWEARVNETIEHPRLKRNVSYRGLVRMEAYKIQKHILGDAPYEPFVSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Y9</accession>
    <name>D4M9Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components</fullName>
            <ecNumber evidence="5">3.6.3.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_17830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.34" evidence="5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17830"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1052"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1097-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="269" mass="29441" checksum="19B2004D7FD9B0B3" modified="2010-05-18" version="1">MSATLKVEALRWGAEGRPIVQGVSLTVEEGEFVGVIGPNGSGKSSLLRCIYRASRPQGGTVLLDGRDLWRMPVKEAARHAAAVPQEMPTQFEFTVREIVAMGRYPHKGPFSGVDARDEALVDRALEYVGMTPCAERTFASLSGGEKQRALIARAIAQDAGLLLLDEPTNHLDVYYQLEILDLIRSAGVSCLVVMHDLNLAAQHCDRLYVMHDGRVVAGGRPRDVLTPELIRRVYRVEAEVTTAPGGAPHVLFLRALKPQRTAELKPNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z6</accession>
    <name>D4M9Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_17950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17950"/>
    <dbReference type="HOGENOM" id="CLU_3365139_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1104-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="35" mass="3966" checksum="CA168D8A2066643A" modified="2010-05-18" version="1">MIPTPPGRRSAAETGKGLRMSTIRNRKKPGRMKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Z9</accession>
    <name>D4M9Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_18040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18040"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1069"/>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1107-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="193" mass="20905" checksum="00FFD9E5A80A76D6" modified="2010-05-18" version="1">MFVERLVLATGSRGKYREFAAMLPREVVGELIFAPKMAQIEVEETGTCYAENARLKAQAWAWATGLPSLADDSGLEVDILGGAPGVLSARIVPGPDQARNDWLLSRLEGRLDRRARFVAALALAIPDRWTLISEGECLGRIATAPEGKGGFGYDPLFLPDGMSASFAAIPPRMKNAISHRAAALRNLLEILMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA21</accession>
    <name>D4MA21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_18610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18610"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1122"/>
    <dbReference type="HOGENOM" id="CLU_028518_5_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1129-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="284" mass="30207" checksum="D992BC2B324A0D5E" modified="2010-05-18" version="1">MAEALVKAARGPWLNHRRRTLCAIGLGAILLAGIFVWGSLLGPGDYGPNYSARYIAPCAAHPFGTDSLGRDMFFRVVAGLSLSIRIGLTAAVISSVIALILGSLSAIFGGRTDSAVSYCVDLCMGVPHLILLILISIAAGGGAAGVITGVAVTHWPNLTRLIRAEILQIRSAQYVQVARKMGKGPLHIALRHIVPHVFPQYAVGLILLFPHAILHEAGITFLGYGLPLDTPAMGVILAESMRHLAAGMWWLAFFPGLALLLVVQLFDVVGDSLRVFVDPHAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA27</accession>
    <name>D4MA27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted glutamine amidotransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_18710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18710"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1132"/>
    <dbReference type="HOGENOM" id="CLU_030756_2_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1135-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="246" mass="26267" checksum="C1690EADF90AED3A" modified="2010-05-18" version="1">MAKPIIGILGNILVTTSSTSGSVMRRSFTNDTCVRSVANNGGVPVILPFVSDLSLMDPLLEACDGLLFPGGDDVDPAYYGEAPHEKLGEVDRALDECWFHAARYAMERQVPMLGICRGAQLLNVACGGSLYQDIGERGEDHLTHVQTEKRHVVTQTACVVPGTRLARLLGREAVPVNSLHHQSVKALGKGLAVSAQAEDGIVEAIESADGLIVATQWHPEDLIESVPVMNALFQDLTARAAARCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA36</accession>
    <name>D4MA36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated RAMP protein, Cmr4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18840"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1148"/>
    <dbReference type="HOGENOM" id="CLU_047795_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1144-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013410">
        <property type="entry name" value="CRISPR-assoc_RAMP_Cmr4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36700">
        <property type="entry name" value="PTHR36700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02580">
        <property type="entry name" value="cas_RAMP_Cmr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="302" mass="33410" checksum="1F1DD01B63BFDAE9" modified="2010-05-18" version="1">MDNVKFERRYWIHTVTPLHVGTGRGVGYIDLPIAREKVTNWPCIPGSAVKGVVADHFGATEEKRSVDGLVRAAFGRKKEPNAIEANSTAGSLVFTDARIVCLPIRSFYGTFAWVTSPFCLERLKRDTSLSILSLVVESAIVTSRTRLVRNGTKLYLEDLDLDCVISQEADACAELIAKAVFADNSDWQAIFRERLAIVSDDIFTFLCEAGTEVSAHIRIDEESGTVAPKALWYEEALPVETLLAGTVWCDRVYRNKEDAKGADGDLTKEKLLENFCSRPLELQIGGKASTGKGQVRCLFESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA41</accession>
    <name>D4MA41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein/domain associated with GTPases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_18950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18950"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1156"/>
    <dbReference type="HOGENOM" id="CLU_130336_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1149-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="122" mass="12365" checksum="AF917BEF05725110" modified="2010-05-18" version="1">MTDSQNAMCHGIIHAAATSAAAVGGSLAQLPGSDNPPLVALQATMIVGLGKVFDMRLSEVAARAICATVLSSMIGKYAARVATQVLVGWIPGVGNAVNATTAAGITEAIGWAVVEEFDKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA43</accession>
    <name>D4MA43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_18970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18970"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1158"/>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1151-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="338" mass="37731" checksum="CE394962A6685C0F" modified="2010-05-18" version="1">MSLYAQLCCPEFLLQAWKRVECRKGMAGTDGQTIDAFRRDRDRNVTRISDSLKNGTYAPSPLRGVKISKNGGGFRRLGVPTVKDRIVFQGANRLLADVWDPLFAPLSFAYRSGRSIADAIDAVIERIRKGRVWFVKGDIKGCFDELSWDVLSACLHDWLPDESLRRLVNQAIRVPVVEGGQIRPRLRGIPQGSPLSPLLANLYLHSFDLQMLQQGFPVIRYADDWLLLVGSEPEAQAALQTAQGILSVLNIAINEEKSGIGNLRCESVAFLGHRIGAERIDADSSGWKRFLNALRQLQGAKTPSERIQARSALSHIRSMYRKSGAIPMEDESMEEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA51</accession>
    <name>D4MA51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein (Cas_APE2256)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19080"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1175"/>
    <dbReference type="HOGENOM" id="CLU_060726_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1159-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013442">
        <property type="entry name" value="SSO1393-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09651">
        <property type="entry name" value="Cas_APE2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_APE2256" evidence="1">
        <location>
            <begin position="66"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="374" mass="41867" checksum="15E899D6113FECD6" modified="2010-05-18" version="1">MRALTVTTCGTSLLTNGADREDIPFLRSNANKREEEYSAEDRGRLLALVEERRGHLLSARDEAEIRRLSAELNGFIGCYRRAGGLADAAGDMHFLICTDTFQGRLTAGLLSDWGEKRGIKMTVQPIEDLNTRDMSAFRLGINNLVEWCSAVLPGYRQASWRILFNLVGGFKSLQGYMQALGMFYADETLYIFEAGGELLSIPRLPVNFDESARRSVVDNFSVARRLTWQSLPMEQCSGLPETMLDIVDGECTFSAWGKLMFDQVSAKLYGERLLPPLSDRIRFSSATESEAGKLDPDKKVLLNRAIDNLSRFLENGTNLSSFDFRALKGDPKEDSTHEFNLWSTQNAWRGFCHYACEEGKKVIVVDSIDAGIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA69</accession>
    <name>D4MA69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I site-specific restriction-modification system, R (Restriction) subunit and related helicases</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_19310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="32618">
        <property type="entry name" value="SbaSGP1ORF19290P"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19310"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1196"/>
    <dbReference type="HOGENOM" id="CLU_009326_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1178-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025285">
        <property type="entry name" value="DUF4145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013670">
        <property type="entry name" value="EcoEI_R_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13643">
        <property type="entry name" value="DUF4145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08463">
        <property type="entry name" value="EcoEI_R_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="348"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="1098" mass="125422" checksum="DDA9E7BD41D35BDA" modified="2010-05-18" version="1">MTNFDLFARVQDFASFTEPAVSAERIYRIDTAACVLNCRRAMEAAVKWMYSVDRALAMPYQDNLVSLISTDEFRDIVDDSLLRRMDFIRKTGNAAAHAGRKITREQAALCLENLFIFLDFVAYCYAEDYREGTFDPSLLEQEAPAAAPVIDTETERKLEELIQENAALREELTARRAEQQQTYVPKPLDISEYKTRKLYIDAMLEDAGWTKGRNWFDEYEISGVPNKSETGYADYVLTGDDGGILAVIEAKRTCVDVAKGRQQAKLYADLIEQKQGRRPVVFLTNGFDTRIVDNQYPERQVAAFHSKRDLEKLFNLQRMRSGLKNIVVDKAIADRYYQEAAIKAVCDSFGQKNRRKALLVMATGSGKTRTVIALVKVLLEQGWIKNVLFLADRNSLVTQARRSFVNLLPDLSVTNLCEEKDNYAAHGVFSTYQTMMNCIDSVRDEEGKLFSCGHFDLVICDEAHRSIYNKYKDIFNYFDAPLVGLTATPKDEIDKNTYAVFELESGVPTYGYELAQAVQDGYLVDFLSVETKLKFIQEGIVYDDLSDEDKETYENTFEDENGELPESIASSALNEWIFNEDTIREALYILMTHGLKIDYGNKMGKTILFAKNHTHAENILEGFEKEYPHLNGCARVIDNYMTYAQSAIDEFSDPKKLPQIAISVDMLDTGIDVPEVLNLVFFKKVMSKAKFWQMIGRGTRRCPGLIDGVDKGKFYIFDFCGNFEFFRMSKGKPTANRIALQGAIFGLQFEIAYKLQDLQYQTERLIAYRSALVEHMTGKVRELNRENFAVRQHLRYVDRYAVSENYQALTYEDTLVVREELAPLIEPEDDDPKALRFDALMYGIELAYLAGKKYNRARHDLLQKVAAVASVANIPEIMMQAELIDKVLHTDYLDHAGIDEFEHIRKGLRDLMKYIPVGKIIYDTDFDDEILSVDWKESELENDDLKNYKAKAEYFVRQHQDHEVIAKLKSNVPLTGADVKVLEEILWSEVGTKQEYEAEYGTKPLGEFVREIVGLDMNAAKAAFAEFLNDTNLDGRQIYFVNQIVEYIVHNGMMKDLSVLQDTPFTDQGSIVEVFTDLTVWKGIRRVIEQVNANALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA71</accession>
    <name>D4MA71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/H+-dicarboxylate symporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_19340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1198"/>
    <dbReference type="HOGENOM" id="CLU_019375_7_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1180-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="434" mass="46393" checksum="9276F76F48972EB4" modified="2010-05-18" version="1">MSEERQEVQQVEQQPVQKERKRVGLASKILIAMVLGSILGWAFKGSYETWSVVTGPLGTIFIRLLRMTILPLIFFSIVTGVAGVADLGRLKKVGGTFLVYWLLASALSAVCGVVWAYIIQPGVGINLAEKAEVFSTDSVDLVQTLVNWIPDNAAAAFGNFNIIQVIIFSLFLGIAIAVLPNDLPAKDGLQKFFDYGNTAITKVVEVVMGFAPVGVLCLMADVTGTLGNEVLTGLGKMLATQYIAYATIIVVILPLILKFVAKVNPLQHYINMYPAMLLAFSTCSSSATLPLTMKCAKERAGVPAEAVELIAPPAATINMQACCAEMPIYAIFAAQMFGLEFGFGQLAVICLLGVIMAAGVAGVPGGGIMMSAIMMQSMGLPLTIVPWVAGIYRLIDMPNTMLNVTGDTVGMVTTTSLLGTLNRDKFNEKKTFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA72</accession>
    <name>D4MA72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SY1_19350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19350"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1199"/>
    <dbReference type="HOGENOM" id="CLU_062618_5_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1181-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="71"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="256" mass="28798" checksum="07B04876F46F97CA" modified="2010-05-18" version="1">MPGQIEPQSVQVIDRTFAVMELVARRGVMSLKDIYSGLELSKATALRIANALVSNGYFERDEKGSYSLSFKSYEIGICAVRRVEYIPFIRETLDHLSGALDVIAQFSVREQDELLCLESFDLAHSNFSVYTRVGQRSQLYATSAGKAILSVSPDEDIRSFWNRMDIRSFTPKTITNLDDFLMDIHKTRQRGYALDQEETEAGLFCVGTPLVNARHKAIGAISLSFSRLDEAALQRVTSALLNQTQRLAYMLSYSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA82</accession>
    <name>D4MA82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Mn2+/Zn2+ transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_19480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19480"/>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1191-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="275" mass="29411" checksum="D3AF530208E0F1EF" modified="2010-05-18" version="1">MTFQEVWEVLSYPFVTRALIVGVMVSLCASILGVILVLKRYSLIGHGLSEVGFAALSVALAFNLPPLYVSTPLVVAASFLIMFVSQRKRVGGDVAIGIAASGALAFGVLVTALTRGMNLDVCSYMFGSILAMTNEDVILSVALSLFVTGLFVLFYNRLFLITYNEDYARSLGINVTLYQFLISFLTALTVVLGMRMMGTLLISSLIILPAVTARRLVRSFRALVVLAACISLACFAVGLFLSFVWNLPTGAGIVSVNVAALMGAVLLARLMGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA90</accession>
    <name>D4MA90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19620"/>
    <dbReference type="HOGENOM" id="CLU_1523014_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1199-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="176" mass="19392" checksum="2D137FC527878748" modified="2010-05-18" version="1">MKAAVAGSGTTAPEERVTAGRSRLDRMVSVKDLLGRIVPQNVRAERLREMVRSWPLVVGAARARNSAPCDLVAGVLFVAAKTPHVAQQLNQMKGNVRRALKERWDLDVHEVRVTLGAPPSRPAVSGQRPGRRAPVIEPPEAEVRRFRSQCPPSLTPEAAQALAHLRAFFTRRFPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAA6</accession>
    <name>D4MAA6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ORF">SY1_19990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19990"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1262"/>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="117" mass="13611" checksum="00EA51A63131290A" modified="2010-05-18" version="1">MRVKGASISNKKRKKLFTVTKGYWGQHKHAYRRAREAYLAALSRAYNDRKRKKRDYRRLWITRISAAVRSEGMSYSVFMNGLKRAGVAMNRKMLSELAIHDMEAFRSLVGQAKSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB0</accession>
    <name>D4MAB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20070"/>
    <dbReference type="HOGENOM" id="CLU_3429805_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="19" mass="2226" checksum="5225E56272EAE147" modified="2010-05-18" version="1">MKSKILNFKVFVLVIVLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC7</accession>
    <name>D4MAC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20470"/>
    <dbReference type="HOGENOM" id="CLU_1432640_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028264">
        <property type="entry name" value="Imm15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15561">
        <property type="entry name" value="Imm15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="189" mass="22587" checksum="8CA259459716CD7D" modified="2010-05-18" version="1">MKMKKTKMKNTLIANIYNKIIRETGLYNLDYFIEEHEGGYEEMPILDYFPQAKFLKRVIKKEEISALLLDIALFFVNVILLYAYNKLTEKQFANFFIAIFVVDFDHLEEDYGDYGHFNPRILVSREADKYTFVSQEMLFDYKRCEKFYKHVSKVAGLGDFMFYRHYDDKNDLDTIYMVPNREGYSPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAD3</accession>
    <name>D4MAD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_20590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20590"/>
    <dbReference type="HOGENOM" id="CLU_2879343_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1241-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="63" mass="7274" checksum="81B101F4E48B84FD" modified="2010-05-18" version="1">MGVEKVLLVIIKSKTNKQEILQNGSNLTIQLRSESYMILSLDRDTVFRKHLKQQSFSLVKIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAE2</accession>
    <name>D4MAE2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="5" type="ORF">SY1_20750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20750"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1334"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_0_0"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="25"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBL28837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="354" mass="39248" checksum="883E6515604A54DD" modified="2010-05-18" version="1">MSRFFSAKYKSLMPYVPGEQPRDRKYLKLNANESPFPPSPRAVEYASEASNLLNLYPDPDCTGLTTRIAELCDVAPEEVLVAGGSAAILNLAFMAFCDRYHPAAFPEVTCGLYRVLAELNGVPFKEIPLEEDFTIRAEEYMALGRTLFIANPNDPTGLAMPIPDLEGIVRRTPDNVVVIDEAYVGFGATSCLPLIHRYGNLLVTRTFSKSWSLAGARLGFCVGNPDLIEDLRRVKDSINLCSIDRVTMAAGLGALSDVEYTTNNCRLIRESRRFAADGLALLGFDLTDSVANFLLARHPRVDGRALYLKLREKGVLVRHFDHPALAQYNRITVGSLEDMQQLLKVLKEILGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAI8</accession>
    <name>D4MAI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferases involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_21580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21580"/>
    <dbReference type="HOGENOM" id="CLU_025996_21_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1297-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="310" mass="35038" checksum="F07FAF6F76AE8EE0" modified="2010-05-18" version="1">MRDIKMSIVTVCLNAAGTVEQAMDSVLSQTCPPFEYIVIDGGSTDGTREIIERYRPRLTHVVLEPDEGIYDAFNKGVARATGDVVGILNADDLYAPWALETVAEAYRQSPDPGVFFGKLAVVDEARCRWTVYPVGDHRRLTGRMSIAHPATFVARSVYDRHGLFDPSFRVSGDWDLMLRFFRWGVPFCPIDKVLTAFRNSGVSSAYSERLFMENRRIYKDALPPLAAFKATLKMYLKRWGRRWIDDLGLSECYARYRDSRLLCAEVSGAFDGSFGRLWEALSHRRPSMPSTASASKKEPKDGRRRGNEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAJ9</accession>
    <name>D4MAJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_21730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21730"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_18_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1308-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="281" mass="30683" checksum="845E0CD62ACB2D8F" modified="2010-05-18" version="1">MTEQKSLELIHVLSGAYFAGVQMDSFMSQLDEVLVSRVRKVEERVQDTSNQFTSLYGVLQALREDFASGSRDAKQGVEAINTINANLMEEMAKSGTSLEGMSETVSNTLNATIKTLELFLEIGKISHNIQRIARQTHLLALNASIEAARAGEHGRGFAVVAHNVQELAAETRTASESIDAKVSEISGAVQGTMENMRSINELFETIQRTLSSFSDCLSNNKTTMESMETMIEDAGEKLNRTSAEMEGAIETMHEASNKVGAMASTISAIVQAQQNLKKIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAK4</accession>
    <name>D4MAK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase FolE2</fullName>
            <ecNumber evidence="2">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folE2</name>
        <name evidence="4" type="ORF">SY1_21810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts GTP to 7,8-dihydroneopterin triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase IV family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1436"/>
    <dbReference type="HOGENOM" id="CLU_062816_1_1_0"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01527_B">
        <property type="entry name" value="GTP_cyclohydrol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022838">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="site" description="May be catalytically important" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="269" mass="30533" checksum="B0FDCF368CD40DA4" modified="2010-05-18" version="1">MKDVQMEADLREIQIDRVGVSNVSYPIVVMSRQDKTQDTVASVSMSVLLPHQYRGTHMSRFIEALEDCCGRISPVTLEAVTKRLCDRLDAPEASIRFEFPYFIRRRAPVSGIESFMRYEANLEGIFSVGKFDMVTGVGVHVQTLCPCSRAISKYGAHNQRAFVAIKVRCTHFMWFEELIAMAEEAASSPLYTLLKREDEKHVTERAYENPRFVEDVVRDLAVALNREPRVSWYSVSITSAESIHNHDAFAEVTRDKGKPAPPDGERGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ1</accession>
    <name>D4MAQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_22590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22590"/>
    <dbReference type="HOGENOM" id="CLU_721121_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1362-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="383" mass="42349" checksum="E87EE729D2863AE6" modified="2010-05-18" version="1">MIAIRERERESLSRKIEHYNELALSKMKESRSILGRLMNLRRSALESQARMDFLEKESGRLQGSMAQLNLSIAETSNLLADLLIKLRTRIVDMYKYSSQERLDVLLATRSTHEALIMAYMLRRLANQDQKVVETLARKADELEQSREKLEKSRAQVQRQQTELKKKRDEFAATIQRTNVLLKNVQGEQKKAKAAAQELMSAQQAIGDKIIALMQEKGARGRREERAPAPSPAPPASPGAPAPQKPQRQPQQYTYLANGAVLEWPLQGPIAMAFGSRVHPVFKTKVFNSGIDIRAASGAPVRAAGPGRCCSPAGSGGSARWSSSITVVGSPRFTPTSPLSRSLKGTRSRRGAFWGRWETAGPTRITGCTSRCAAAAGRRTRCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAQ4</accession>
    <name>D4MAQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, N-terminal subunit</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22640"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1507"/>
    <dbReference type="HOGENOM" id="CLU_009227_4_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1365-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="268" mass="28447" checksum="923E32AFB79CF3C8" modified="2010-05-18" version="1">MKPGEGCGTEALQERALCVRRDIAGMPGALHDGYLFSAVSSVDLLVWLYGRVLRVCPEAPLDEGRDRFVLSRVAAAPALYATLAEYGFFPREELWEYRRLGGMLQSAPEFRHAPGIDVSCGVRGIGLGLALGLALALRDAAPEVRVVCLLGADELASGPVYETLTLAAEAALPGLILIVESDGEDADAARALSAVAGCEAVRVDGHDVEALNAAWGELTAESRGKGMRVLLARTVRGRGLPHVSDDLMDDEGPLDRQAADVLISRMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW1</accession>
    <name>D4MAW1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="8" type="ORF">SY1_23510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23510"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1593"/>
    <dbReference type="HOGENOM" id="CLU_048199_1_0_0"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="14"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL29006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="286" mass="32259" checksum="41A5275BAB8B8309" modified="2010-05-18" version="1">MGDAPVTRARRTNDLWLTEESSEGLRLSLKVTDVLHRERTKWQDILVVDTPEYGRTLMLDGAFQLTERDEFTYSEMMAHVPLCSHPDPKRVLIVGGGDGAILREVLKHPGVERCTLIDIDERVIAASKEWLPTVGCALSDPRADVRCMDAMEYLRTTSDRFDVAIVDGTDPVDFAAGLFQSPFYRDLKAVLNERGMMTELTESPFTDTALMRQALREMRAVFPVVRTYWGVVPTYPSGMWTYGAASLSADPATPLREVSGTRWYTNAIHRAAFILPPFLEELIREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAW5</accession>
    <name>D4MAW5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="7">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_23600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23600"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1601"/>
    <dbReference type="HOGENOM" id="CLU_030140_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1426-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL29010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="315" mass="33765" checksum="FF8D3C5E40DFAF57" modified="2010-05-18" version="1">MFQAEGYEVVAINDLTSPEVLAHLLKYDTTHGRYHGVVEADENSITVNGKKITIYAEKDAANLPWKDLKIDVVLECTGFYTSKDKAGAHVKAGARKVVISAPAGDDLPTIVFNVNHKTLTPSDTIISAASCTTNCLAPMAKALNDLSPIVSGFMTTVHAYTGDQMVLDGPHRKGDLRRARAAAENIVPASSGAAKAIGLVIPELSGKLNGAAQRVPVATGSTTILDAVIKGSFTADQVNAQMKKEASESFEYNTDEIVSSDIIDSTAGSIFDATQTRVIAMEDGNTLVQVVSWYDNENSYTSQMVRTIKYFSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAX8</accession>
    <name>D4MAX8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="6" type="ORF">SY1_23850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_23850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1624"/>
    <dbReference type="HOGENOM" id="CLU_019250_2_2_0"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="252"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL29023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="500" mass="54494" checksum="111AE0734E02C7F5" modified="2010-05-18" version="1">MKGIMVQGTSSDSGKSFLVTALCRLLSDRGFRVCPFKSQNMSNNACVTRDGREMSRAQAVQAEAARLEPETFMNPILLKPRRDVSSEIVLEGRALDTPAERGYYRTFTRTLGIEAVRRALRRIEERFDAVVIEGAGSPAEVNLNEFEIVNMRVAREADVPVVLVTDVDRGGSLASIVGTLELLGEDRGRVKGLIFNKFRGDRSLFDPAVVWIERRTGVPVLGVMPWVEGAAIAGEDSLNVHWGRTGGEGLSIGVVRFPGLSNFTDLDPFELEPDVELVGLDADTPERTLRSLDAVLLPGSKNTMRDMAWLERTGLARAVRELSRAGRCVFGLCGGYQMLGERLLDPDLKENSEIREIEGLGLLPSVTAFGAGEKRTVRTEGRVRRQLSAGEVPVAGYEIHFGVTHPVEGSSCPALLDVAGGGVEGLARPDLSVAGTYLHGIFDADAFRALWLNAVRRSRGLEERAVTDTRAMKEHAYDALARAAERHLDVGAILRLMGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAZ8</accession>
    <name>D4MAZ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartokinase</fullName>
            <ecNumber evidence="10">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SY1_24140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="10"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24140"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1656"/>
    <dbReference type="HOGENOM" id="CLU_009116_6_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1460-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="376"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="6"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBL29043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="441" mass="48269" checksum="A3AC664A35BE182C" modified="2010-05-18" version="1">MKKVVKFGGTSLADSAQFRKVRDIVLEDEARTIVVPSAPGRRSANDVKVTDLLYQCYGLAAAGKDFRRPLQAVRDRYAEIVQGLALSLPLDEEFRKIEENLTSAPERDYTASRGEYLNGLVLAEYLGFAFIDAAALFFFDDAGNFDAARSHGVLTARLDEAPRAVVPGFYGTDPAGRVRTFPRGGSDITGAIIAGACGASVYENWTDVSGLLMADPRIVKNPRVIRDITYSELRELAYMGATVLHEDAILFVRRAGVPINIRNTNQPEDPGTWIVGHTAKQSSHTITGITGKKDFCSIILAKDRLHSDPGFHSRVVRCFEESDVPLEHLPSGIDTMTVVVHASHFLDREQEVLARLARVARPDTLDIEPGLALIAVVGRGMKSRSGTAARIFTALAKVRVNVRMIDQGASELNVIVGVLNEDFERAIRSIYGAFVEEDPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MB10</accession>
    <name>D4MB10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_24390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL29055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_24390"/>
    <dbReference type="HOGENOM" id="CLU_1978272_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1472-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL29055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="126" mass="14967" checksum="B275D2E14E9E4AAD" modified="2010-05-18" version="1">MMTIKYWWNKMFDHEIEFFFFHLYVFFRPFETIFNTSSSFGAKIFASVFAFLVFLFTLKVYFFHSVLWAKVEFFVFAFIITPLLTVGVLSGQITQSVAEMASLLAEEMMLTCIVYRAYLKMMKRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D4M6Y6</accession>
    <name>D4M6Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-threonine 3-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.103" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00290"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1728"/>
    <dbReference type="HOGENOM" id="CLU_007383_19_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-12-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="320" mass="35699" checksum="22922E4F13FDD336" modified="2010-05-18" version="1">MKRIMVSGCLGQIGTELVTRLRRDYGAANVLATDVREDAAHALPEGPFEILDVREAERYAECVSKFKPDTIYHLAGILSANAEKKPQLAWQINIQGLCNALEMGREKGCAVFFPSSIAAFGPETPHDKTPQDTIQRPNTIYGITKVAGELLAEYYHKKWGVDTRGVRFPGLISYKTLPGGGTTDYAVDIYYQAVQAARYTSYIAAGTYMDMMYIPDAIDGMVQVMEADPARLVHRCCFNITAMSFEPEQVAAAIRVRIPSFVMDYDVDPVRQAIADSWPNSIDDSAARAEWDWNPKYDLNAMTDDMLKNLRLKLGDEAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M712</accession>
    <name>D4M712_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ORF">SY1_00810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_00810"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.237"/>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_0"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="6"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="363"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL27657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="461" mass="51787" checksum="5BCD619F062EC197" modified="2010-05-18" version="1">MALWAGRFEKDMDQLVKEFNASIGFDVRAYRENIEGSIAHVAMLAKQGIVTEAERDAIVAGLERIREGLDAGTIRFTVEDEDIAMGVEARLIKDIGDVGKKLHTARSRNDQSLLDTTMLLRREMREIERALVDLMKVILDRAEAGTDVLMPGFTHMQHAQPITVGFWFMAYFQMFRRDMDRLQDCRARTDFCPLGACALAGTTLPIDRQATAEALDFSAPTENAMDTVSDRDFMIEFLSAASISMMHLSRWAEEFVWYNSTEFSYLALDDSFCTGSSIMPQKKNPDIAELLRGKVGRVYGDLMGLLTVLKGTPLAFNKDFQEDKEKVYDAIDTWKASLRIFEKMIEAASFRSDALNAQLEKGFLNATDAAEHLVVKGIPFREAHEIVGHMVRACEKKRCRLEDLTDTDLALIDPRLSRSTVGDIGIRACVNARRSYGGTAPAEVRRQVEAGREWLARARGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7B7</accession>
    <name>D4M7B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_02370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1690"/>
    <dbReference type="HOGENOM" id="CLU_936126_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-145-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="297" mass="33539" checksum="30C75785FA65A774" modified="2010-05-18" version="1">MLPDVKARRTGKFDDWRGYRNGKHNGEDWAAPEGISRAVEEADSDLEAARIAVVVSEDPVAALAMTEGSEYLLPDTAAGLRKKLSGEVERLERQAAAEAEKAAAYAATDALMDRFGTDERAAWNAMENDPSLDPETRERIWGKYKARLSDRERWEAQRDRDYMSGWMDKIADSSSLEEAQQLIQDSGADGKQRVQMERWAAQIHRPEKFKEDVRDWAQAFKEVTNGQIKTDEELIYRWGGRLSSSTMKSLVRMFYKERASGTGKKGADYVGYSFSKAITTAILRGISRTRNRPGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7C7</accession>
    <name>D4M7C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Organic solvent tolerance protein OstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_02510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_02510"/>
    <dbReference type="HOGENOM" id="CLU_1011040_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-157-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061143" evidence="1">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="2">
        <location>
            <begin position="114"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="275" mass="29151" checksum="C57377FCAD70640E" modified="2010-05-18" version="1">MGLAALLALWLAGAAFAVDEQGLPDKAKLSANRMRFDSTTGDFLAEGEVLITADGLTVRAPRGSGNVPRREAAFDSGVTASGTWMGDAVDLRAGRLTLNFAEAPACRLQDGVKGAVGTMGLDADRLTLIGAGGVGSPTEEDQQTKFWIVGAHRLEDRSRGLTFGADSIEGVLREGALASMTAKDRVWVRGRPKQSGEPVSINGDHALYSLQRGSVVLSGRVVAVQGGRTLRSDSIVYFPDQNRVEALGGITRNESGTVSADRAEITIDLKRERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7J9</accession>
    <name>D4M7J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_03680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03680"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1849"/>
    <dbReference type="HOGENOM" id="CLU_035307_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-229-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018387">
        <property type="entry name" value="YcgA/YfcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF6">
        <property type="entry name" value="PTHR43652:SF6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL27844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="477" mass="51483" checksum="AD84A812B537D529" modified="2010-05-18" version="1">MMDERLELERGGRGPSFLERITAPHTYAILFFLAVLAVIGTWLLPAGEFDRVLNEAVGRNVVVPGTFKAVEQTPVSFFGLFTAYMEGFIEGADVVGFVFFAYTSWYVVLRTKALHAAVGAMLRVFGESQRRYIMPFFLFVFGFCASIFGMFEESFGFLPLFVGMAIAMGYDGMVGAATVAVGVGMGYSAAIMNPFTVILAQKCAELPLLSGWPFRLVLSLSFFAVSALYVARYAARVKADPTQSLLHGVDMGELHMDHDELVSMKFSLRHKLVCLICLGAVGVLMWGVIAQGWYFNELGALFVLMGILGGVVGGLGVNGTAKAFADGFCDIAAGCLLIAFGRTMLVILQKGHIIDTVAYYCSLPLSVLPKWLAAEGMLVVQNLINFFIPSGSGQAVVTMPIMAPLADLLGISRQVAVLAFQFGDGLSNVMWPTADIPIICAIAHIPLNKWYKFFLPLFGIGLLMQAAGIAAAVLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K1</accession>
    <name>D4M7K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monosaccharide ABC transporter substrate-binding protein, CUT2 family (TC 3.A.1.2.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_03730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1854"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_5_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-231-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061153" evidence="1">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="42"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="328" mass="35147" checksum="52270DD194C59D0E" modified="2010-05-18" version="1">MKKTVALLLVALVLFPSMAFGVDSSQEAKRFKVWFDTGGGPGESYGTVLQNGAAAAARDLDLDIVFVYSDWNAEKMLENFRQGLTSKPDGMVVIGVPGDDAYEPLIDQAYAQGALVTCVDTPLPRLYQKYQSRGFGMIGPDNYNQGRMLAERCVAQFDLKKGDRVMVWGLKSLPGRGRRAQAILDVFEKAGLTADYIEISPEINKDATLGGPVLTGYLSSHEDCRLVVIDHGALTAQSGNALRSAGMDPDRVAVAGFSLSPATAEAIRSGYLDLVGEGQPYLIGYLAVVNLVQSRLCGFGGLVIDTAGGFVDKDNIEQIAPLAEKGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7K6</accession>
    <name>D4M7K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative p-aminobenzoyl-glutamate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_03860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_03860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1864"/>
    <dbReference type="HOGENOM" id="CLU_040132_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-236-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015558">
        <property type="term" value="F:secondary active p-aminobenzoyl-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902604">
        <property type="term" value="P:p-aminobenzoyl-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004697">
        <property type="entry name" value="AbgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30282">
        <property type="entry name" value="PTHR30282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03806">
        <property type="entry name" value="ABG_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL27851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="518" mass="55732" checksum="2D050CF99934330A" modified="2010-05-18" version="1">MKETGRAQKKWTLRAMDAVERAGNALPDPALLFVILTALTIAASYFTAKSGVSVSYEGVNSATGTIETIHAQAYNLLSLEGFHYMVTSVIKNFTGFFPLGTVFTIILGVSVCEGTGMLNALLRKLVSKTPKALISAMIVFLGVMSNVASSTGYVVLVPLGAVTFIACNRHPIAGLAAAYAGVSGGWTANLLLGSNDPLYAGMSTQAANILNPDYVVQPTGNWYFMVASTVLVVLIGTWVTDHIVEPHLPLYQPEEDARVQDLTLDEKKGMRAAGFAALIYVVVMLLLIVPSGGLLRNPTTGQVLGSPFMSGIIFFMMLLFLIPGVAYGVASGKIKSSRDLTNLMSTGIAGISSFLVLLFFAAQFTFFFNKSNLGIIISVKGAHFLESVGLVGLPLLWVFILVTAFINLLIPVDTAKWAMMAPIFVPMFMHLGYAPELTQLVFRIGDSATNIITPLMPFFVMIVAYFQKYDKKAGIGSVLSTMLPYSIALLVGWILMLSLWFVLKLPIGPGAPLFYGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7S9</accession>
    <name>D4M7S9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="2">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_05100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="2"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05100"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2004"/>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-311-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="180"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="485" mass="52675" checksum="ECF2A7637D52FA0F" modified="2010-05-18" version="1">MKGYPGMRGIAYKEDLLWEKSRKGRVGISIPEADVPGADLDPSLVGAEPNLPELSEVDVVRHYTRLSTWNFGLDTGMYPLGSCTMKYNPKINEAMAALPGFANLHPLLPDECMQGALKLMYEFEQDLLKITGMKAATLEPAAGAQGELTGMLMIHAYHAHKGRQRSKLIMPSTAHGTNPASGALCGYTPVPVELSADGVVTPDAIRAIMDEDTAGIMLTNPNTLGIFENHVAEVAEIIHEKGGLVYGDGANMNALMGYVDVKKMGVDVLHMNVHKTLSTPHGGGGPGAGPVVVGEALEPFLPVPRVRKDGDRYYLDFNIPLTIGRLQSFLGNFAVLVRGFTYTRTMGRDLKAATEAAVLNANYVKAKLRGDYHLPFPQPSLHEVIFNDEEQKKNGVTTMDIAKRLLDCGFHAPTVYFPLVVDSALMIEPTDTEPKEELDAFIAAMKDIAADARTNPERVTNTPQNTIVSRPDETLAARQLILKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7U6</accession>
    <name>D4M7U6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SY1_05320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SGP1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05320"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2025"/>
    <dbReference type="HOGENOM" id="CLU_022305_0_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-328-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="189"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBL27941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="462" mass="49504" checksum="50302CC54F5E5BE5" modified="2010-05-18" version="1">MQSVFDIFRVGIGPSSSHTMGPMRAALRFLEELRAMGLLERVGSVRCDLHGSLALTGKGHMTDRAVLLGLWGVKPEEADPDVIQEFVDLVDRTRRLPLGAFPRLEDGRSIPFDPERDIAFLPKQLPLHENSLVLHALGPDGTELHSNAYYSIGGGFVVEAARFDAPDGVSGDVPYPYASADELIAVCAEHGLSVSTLVMKNERALHPGVDVQAHFERIWALMSACMERGMRTEGILPGGLHVARRAAPLLRMLSSDRPLSSDPMQILDWVNVFALAVSEENAAGGRMVTAPTSGACGVVPAVLEYYNRYVRSTTPEDRTRYFLTCGAIGLLFKANASISGAEVGCQGEVGVACSMAAAGLTELSGRSPRQVTTAAEIAMEHCLGMTCDPIAGLVQVPCIERNAVAAVKAINAAHMAMHRSTPPLISLDEVISTMYQTGKDLSAKYRETSQGGLAAQPRRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D4M7W3</accession>
    <name>D4M7W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_05550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_05550"/>
    <dbReference type="HOGENOM" id="CLU_039613_8_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-345-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL27958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="307" mass="35091" checksum="EB23993768EA522A" modified="2010-05-18" version="1">MNLADIETFLTVVNTKSVTQTAKMLFLTQPTVTHRLNSLEAELGFPLMIRKKGCKQVELTERGLDFIPVAERWVSLWKETQNLSGAEDRVPLSIGCTDSMNVVLLAPLYEGFLKTKPQVNLTVHTHQSRELYGLLANHDIDLAFVYHNLPYKNIRSDKIFEERLYLAQTDEPAVSKPVVRMNELDTSKEIFMSWDDNYQIWRGICAGGVYRPRVSVDTVAMLDRLWSQPDHWVIAPESVIAELSRRRRLYVSEIESAPPNRSVYKIKRQAPKLASHRVVALFESAVEEYLGDLKFPIKIGEVFGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D4M802</accession>
    <name>D4M802_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoglycerate dehydrogenase and related dehydrogenases</fullName>
            <ecNumber evidence="6">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_06200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL27997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06200"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2106"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-384-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="91"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL27997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="318" mass="34320" checksum="F5C5CC774A4419CB" modified="2010-05-18" version="1">MELLKMGAIDVHVADDPDPNRYLDVLQDADALIVRIARCDANAIEHSPRLKVIGRTGVGYDTVDVKKASERGIPVVLTPGANNRSVAEHAVAMMFALSKNLVEAQNEMCAGNWEIRGAGKAFELEGKTVGIVGMGAIGREVATICRGCGMKLIGYDPFLSRDKIEALGALYCADYEDLLKRADVVTIHVPLTNETRGMIGARQLASMKRTALIINCSRGGIIDEGDLVRALKDGVIAGAGTDVYCHEPPKPDDPLLHCPNLILSPHSAAQTREAVVKMAQMCVRGCLAVCSGKKWPHVADRSVYDHPIWAGRDWAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M830</accession>
    <name>D4M830_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SY1_06570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2146"/>
    <dbReference type="HOGENOM" id="CLU_036879_3_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-412-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="91" mass="10079" checksum="E23340BD2600386E" modified="2010-05-18" version="1">MRHMMRNALIPIVTAVGLQFGHLLGGAMLTETIFSWPGLGRLMVDSIKSKDMPLVLGSVIFLAVMFSVVNLVVDIIYAFVDPRIKSQYQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D4M838</accession>
    <name>D4M838_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ORF">SY1_06720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_06720"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2165"/>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBL28033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="251" mass="27338" checksum="B087A73751D1047F" modified="2010-05-18" version="1">MPGSALLRDILDAALSEQERARIEGRDLAALQAALGYSFRDEGLLEEALCHASFANEHGLAVSNERLEFLGDSVLGFVVARALYRLYPEAREGDLTQKRAELVCGRSLRDRARELNLPPLILHGHSVRDEALPTSMCEDAVEALLGAVCLDGGVQAAEGVIGRLFLQEAEVRAETDVSPKSRLQTWLQARRIPLPTYELVSVTGPSHAPSFRVRLRVNGVEHTACGSTRKGAESDAAERVLEDLMSLEVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M899</accession>
    <name>D4M899_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_07730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07730"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.2265"/>
    <dbReference type="HOGENOM" id="CLU_015805_2_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-484-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="217"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="303"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="392"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="516" mass="58818" checksum="D424BA41814D7DAD" modified="2010-05-18" version="1">MEQEMNRDMELEQAAQSDGQEMDQGKLMEEYDVATRLHPGEIIKDGTVVAETENGWLVDVGYKCEGLLPEKEWTHRILIEDVEKPKTGDKIEVQVVKIRDGEEAQLLLSRWRSEFDRRWAELEALLEGNETVQVKGLRKVKGGLMVECCGLEGFIPMSHIAENGRGSNLSSFIDETFEVKPLERDKRKHRLVFSRKDLVAKENAEKRAKFYDEVHEGDVLEGEVSSITDFGIFVNLKGAMDGLVHVSEITWKRNVRIRDLYKKGDKVTVKVIGLDKEKDRISLSIKQVQGDPWLTAGERIHKGDVMKGVVTNVTDFGAFVELEPGIEGLIHIGDISWARIKHPRDTFRKGQEVEVLVMDIALSEDPKKCRISLGYKQLNDPWKDIDKRYAVGQDLKVKVVRLAEFGAFVEAEEGVEALIHISQLSNRRVEKPGDVLHEGQEVVARMIEVNPEQRRMRLSLSALEEPTEPQQPKRDERQQHRKESREDRRSNAGDAGLDEGGLYQNPFAEAFKDKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8C0</accession>
    <name>D4M8C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family (UPF0227)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_07970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="9bact-d4m8c0">
        <property type="family name" value="abh_upf00227"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_07970"/>
    <dbReference type="HOGENOM" id="CLU_090996_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-508-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008886">
        <property type="entry name" value="UPF0227/Esterase_YqiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05728">
        <property type="entry name" value="UPF0227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="184" mass="21049" checksum="2E17EE718DA01581" modified="2010-05-18" version="1">MFINIHGFGGQGENTKYLWLRKTYPEEEIFCPTFDYTTAHPEEVLSRYEAEVRAQVKAGRSVRVVGTSWGGFFAYCLNALFPSLPTVLVNPSLNPHLSRRCIVLNHDLLLEYMEVLSRHMLRHSDASCAVIIGSRDEVIPHEVVTVPIFAPESVHRFDVQHSFDMDAEPELPRLMMEHFGRTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G6</accession>
    <name>D4M8G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">SY1_08740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08740"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.71"/>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="181" mass="20290" checksum="7234EBFFA6C25C08" modified="2010-05-18" version="1">MVPRMLEKYKKEISPALLKEFGYKNVMQLPRVEKVVVNIGVGDAKLDIKFMDAAIAELRAITGQQPLLKRAKKSVAGFKVREGMPVACSVTLRGTRMWEFLDRLISLALPSIKDFQGVSRRGFDGRGNYNLGLREQLIFPEISYDKVIRSRGMNVSIVTSASTDEEAHALLKGMGMPFNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8G7</accession>
    <name>D4M8G7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">SY1_08750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_08750"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.72"/>
    <dbReference type="HOGENOM" id="CLU_093315_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBL28162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="107" mass="11891" checksum="5C1B24376199E136" modified="2010-05-18" version="1">MSVRLKKNDRVRVISGKDKGKEGKILRRIPDRDLVVVEGVNLVSRHMRPTQKNPQSGIHKQEAPIYASKVMLVCPHCGAAVRVGSSFLESGKKVRVCKKCSEIIDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D4M8T6</accession>
    <name>D4M8T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Co2+ transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_10860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_10860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.295"/>
    <dbReference type="HOGENOM" id="CLU_058596_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-687-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061021" evidence="1">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="264" mass="29347" checksum="D690C465ADF4A070" modified="2010-05-18" version="1">MKKIVVLSLFALFAAALPASAHFQMLYTPETILDKGGEVPLKLVFTHPFEAGHTMDMGKPQEFFVVNKEKKTDLLDTLKPITWTSLENKGRAFETSFKLKGMGDYVFCLVPAPYYEQSEETYIQQITKVIVNNGSLPTDWDAEIGLKAEIVPLDKPYALWAGGVFRGVVKGDGKPVPFAEIEVEYMNHKPDMKKNSFEKKATVEAPHDAFVTLTIKADANGTFTFAMPKAGWWGFAALGAGPDKEFEGRELSQDAVIWVQATKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D4M900</accession>
    <name>D4M900_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_11850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_11850"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.420"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_4_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-753-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="220" mass="24548" checksum="0D055266AE49A0AE" modified="2010-05-18" version="1">MDLNFVGQVFLKMLPALPRTLSVTVLPFIAALFLGLMVTLPIVYKIPVLKPLCKVYVSFFRGTPFIGQLFMIYFGLPRMFACLSAMDKIEGFVLTMALNSSAYLSEIIRGAFLAVDRGQIEAAKSINLSRMQTLRLIVIPQAIPVAVPGIVNVLIDAIKGSSLAFTIGILDITAVAKIQAGITFRYFEAYMAMVMMYWFIVLVLEQMQKRYEQRIKLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D4M997</accession>
    <name>D4M997_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily phosphatase, subfamily IIIC/FkbH-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_13480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_13480"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.583"/>
    <dbReference type="HOGENOM" id="CLU_018095_1_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-853-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010037">
        <property type="entry name" value="FkbH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01686">
        <property type="entry name" value="FkbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="542" mass="59393" checksum="4FAB632448321B05" modified="2010-05-18" version="1">MRQTDNGPLILLANFTAESLAMRLCGEGVDARTTPGFDTWRMELLSETSSIWQEPRGVLLLLLHGPALFPDGVDAGFAGVLDDALTLIRRARDAHPDRTLVVSTLDLPSPPALPLAAADPAREASHRWRSGLAAMDLPVLDLESLAAEVGRARFYNAKTWYFGALPFSAEGEKRLAQEASRVLRVLTCSRRKCLVLDLDDTLWGGVVSEDGLEGIALSDHGVGAAYRDVQALVKALSAQGVLLAINSKNDVEDALLPFRKHPHAVLREEDFAVVRANWRPKPENVRDIAGALNIGMDSLVFIDDNPAERAAVRAACPEVEVPEFPPDTSALPAFIREVADRFFTAPCLSAEDAGKTAMYRAEARRAEARAHASLGDYLASLEMQLSLRPLGEEEIPRAAQLCAKTNQFNLTTRRYSEADLRAMTQDERRRGWIAGLSDRYGDYGRIALVIVELDRGGTSASFDTFLMSCRAMGRGVESALLAWVEELLAAEGVTRLTGRYLPTAKNGPVKDFWRDMGYAQDGDAWTLSAPFPERRSCLCRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9K2</accession>
    <name>D4M9K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SY1_15370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15370"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.796"/>
    <dbReference type="HOGENOM" id="CLU_612169_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-959-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061853" evidence="2">
        <location>
            <begin position="27"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL28547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="447" mass="47892" checksum="80C04D167DC71649" modified="2010-05-18" version="1">MKGSKWILSAGLFCVGLAGLPSPGEAAATLSADDFLPIVQAPEEQRGELSAVRQPDAVKTEADAVLEQPVTSAATVQDAINAVVAERKQGCTMIAVPSGGYGFVATGIGTYRKNMDNITAERIAQRNAYVEAYMQAKSQMASLLGEMAVKGVTTFDRKTETLDTDSKALRNQTRDLNEHQKAVVYGVLKGYVTYEVHDDIDKGIVYVTLVSTPRTRGQYARPDSDTLIAATLNEGLNTMLSEIQNNLVPPVGGRIIDVPTTGEVAFVGFGSAVVRKDKDPALQKDLTLSAERTAELRASDALCGIITGEKVSAASALDESTQTAVRDFETIAQRDPTTGVVSQVDVANAEGRKKEFRSRQTFQQTIESARQGLLPPGVQRRTWTDKDEAFAWGIAVYAPSLTDAAAAGARDMENAQIVQPVQPKQAPQPESSDKLEQGVSGTVKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9M2</accession>
    <name>D4M9M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage protein U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_15780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_15780"/>
    <dbReference type="HOGENOM" id="CLU_102468_1_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-979-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009734">
        <property type="entry name" value="Myoviridae_GpU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06995">
        <property type="entry name" value="Phage_P2_GpU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="126" mass="14088" checksum="27A2659EF6302A99" modified="2010-05-18" version="1">MMLSLGDFQFGVDAAAYAELSLKAEYPWAKVDRLQNTPQHQAMGLEVRSVSLRGTVYPSYREAGLSQIEALREAAAEMKPQPLMAGNGRYLGSWVVKSISQTDSVFFKDGAAQKQEFTMEMERFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9Q8</accession>
    <name>D4M9Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SY1_16260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.897"/>
    <dbReference type="HOGENOM" id="CLU_024867_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1015-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBL28603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="481" mass="51536" checksum="0D467B51CA069208" modified="2010-05-18" version="1">MESFGSYVNAFNDLVWSDALVYLCLITGVYFTVRMKFPQIRLIKDMVRLLIGKGSQSGISSFQAFATTVGSRVGMGNIAGVSTAIYFGGPGAIFWMWLISILGAAAAFAESALAQAYKVKVNNQYAGGAAYFSEQGLHFKPLSILFAIATILGPGILMPGVQVQSIALSFDMAFQVNDIVVGVLCTVLVAMVICGGIKRISVVAELLAPVMCVAYILITLYIFAVNIDKVPGAFALIFRSAFGMEQAFAGIVGAAISWGVKRGVYSNEAGQGSGAIVAAAAECDHPAEQGLVQAFSVFVDTLVICTASALIIILTNSYNVVDLQEKAIVEHIPGVAYGILWAQTALVRAVGSWSGQFLAIIIVLFVFTSLMGYYYQAESNVTYLSSGNPKAIWAFRIAFLISCFAGVLIENKVVWSMGDTGCGLMAWFNIIAILLLSSKACAILKDYEEQKRSGVKPLFDPKKFNVPDVSAVWADVARKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9S0</accession>
    <name>D4M9S0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SY1_16430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_16430"/>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1027-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="110" mass="12110" checksum="15A86D14298F08BA" modified="2010-05-18" version="1">MSAIVELTKENYEAEIKESPIPVVVDFWGPKCGPCMALMPKYHELADNPKYEGKVKFCSVDTSKNRRVAIGLKVMAQPTFLFWKGGAEVARLSGDGTSIEGITAEVDKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D4M9V0</accession>
    <name>D4M9V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SY1_17150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_17150"/>
    <dbReference type="HOGENOM" id="CLU_1784032_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1057-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBL28645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="145" mass="16081" checksum="2D0FA00CF2E6D068" modified="2010-05-18" version="1">MNFVFALKVGSRKHRLIAALLFIIALRHCARALDEFGMRAALSLKATSFAPVRGGAERSGAEGLFRILFAWSESGPRACRLWKGAVLGFVGSDLAAHSTHQQAVERFVVDGRQNFSFQERIFVDAHLSEYGLRFVWGGRPFNLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA17</accession>
    <name>D4MA17_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ORF">SY1_18560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_18560"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1116"/>
    <dbReference type="HOGENOM" id="CLU_108953_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL28712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="157" mass="18119" checksum="8058C253817D7FF2" modified="2010-05-18" version="1">MPEKANKTVAQNRKARHDYFIVDAFECGIVLTGTEIKSVRAGNLNLKDSYASLDEGELWLVGMHISPYEKGTYYNHEPERRRKLLLHRHELLRLKGRVREKGLTLVPLSVYIKEGRRAKVELALARGRTAHDKRDAIADRDAKRDMARAVRHNGRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA48</accession>
    <name>D4MA48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_19040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19040"/>
    <dbReference type="HOGENOM" id="CLU_1967332_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1156-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="127" mass="14515" checksum="8D4AA70E1F5F40E6" modified="2010-05-18" version="1">MDEVKKTDERQHPIEHRENFIAALTETGKAIRAHIGEINTVMLRAVAQNQALERCHQKTWGARIERMNRELSDFERCVLLRPSLCVMGRRGAGKTTLLNSWLGKTKNKKGSLSRPFPTAPRTRPPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D4MA89</accession>
    <name>D4MA89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SY1_19570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_19570"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1225"/>
    <dbReference type="HOGENOM" id="CLU_058411_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1198-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016732">
        <property type="entry name" value="UCP018688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41373">
        <property type="entry name" value="PTHR41373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018688">
        <property type="entry name" value="UCP018688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LPG_synthase_C" evidence="7">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBL28784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="301" mass="35297" checksum="0171C80B0A2A2BC9" modified="2010-05-18" version="1">MLQFKPIAWEDKESYTSCFERCPVHYAEYSFFGLWGWLESVPIDLAFDGTLYWLRSRGPKPGICGPVGDWTRFDWHRTLEHFALEEALFDVPEGVVQLIPEDLEEVLEVEEDRDQWEYVYSVPELIELKGKKYAHKRNRVRAFSSSYEWEYVPMLPEDFPAVMEFQERWRAHRDSTMTEDETVSLYDEDLAIRAALERWDDFPFLGGILKVEDEIVAYTIAEELDSRTLDIRFEKAFGEYAGSYQAINQLFLKNQGAGYDWVNREEDMGEEGLRASKLSYGPTDMLKKYGVHLKGRPAETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB3</accession>
    <name>D4MAB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20140"/>
    <dbReference type="HOGENOM" id="CLU_3328229_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1221-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="38" mass="4234" checksum="974D058E765A0452" modified="2010-05-18" version="1">MTPRITPCFASSWSTYSTRRSTPSSSSRRKTFSCTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAB6</accession>
    <name>D4MAB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylmalonyl-CoA mutase C-terminal domain/methylmalonyl-CoA mutase N-terminal domain</fullName>
            <ecNumber evidence="7">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_20260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="7"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20260"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1281"/>
    <dbReference type="HOGENOM" id="CLU_009523_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1224-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="6">
        <location>
            <begin position="601"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="733" mass="80690" checksum="359E0A1072533D52" modified="2010-05-18" version="1">MSVSYKNPDFTQISLNCPTSGPDFDEAVWSRNFEAETGSAPEAMTTRTMEQIDVPPLYTEAKGGHLAHLAFDKPGLPPFLRGPYPTMYVTRPWTVRQYAGFSTAEESNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVVGDVGKAGVAVDSILDMEILFSGIPLDQMSVSMTMNGAVLPVLAFYILAAEEQGVDKSVLSGTIQNDILKEFMVRNTYIYPPRTSMRIIGDIFAYTSQYMPKFNSISISGYHIQEAGGTADIELGYTLADGLEYLRTGIKAGLTIDAFAPRLSFFWGIGKNYFMEVAKMRAARMLWAKIVKGFDPKNPKSMALRTHSQTSGWSLTEQDPYNNVERTCIEAMAAALGHTQSLHTNALDEAIALPTDFSARIARNTQLYIQDETKVCKVIDPWGGSWYVESLTSELLRRSWAHIQEVEELGGMAAAIDTGLPKMRIEEAAARRQAHIDSGAEEIVGVNSFRLDKEDPLEILEVDNTAVREAQIARLKKLRENRDQEKVKECLDAITKATETGEGNLLALSVDAARARASLGEISAAVEKVCGRHQAVIRSISGVYSSEFKDADVIDEVRRMTDDFERKHGRRPRIMVAKMGQDGHDRGAKVIATAFADMGYDVDIGPLFQTPAETAQEAVDNDVHVVGMSSLAAGHKTLLPQLVDELKKRGREDIMVVVGGVIPAQDYAFLREHGAAAIFGPGTVIPVSAKKVMEELNRRVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAC1</accession>
    <name>D4MAC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_20340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_20340"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1290"/>
    <dbReference type="HOGENOM" id="CLU_1358790_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1229-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003061568" evidence="1">
        <location>
            <begin position="29"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="201" mass="23004" checksum="0F59FFF8D542BE1C" modified="2010-05-18" version="1">MEHMKQRLKASAALAVLLVLALAFGASAASFGKDEMRRMGVFISNFTEVGLYNFDLDLDAAELIRFGIQHNYLNNYKSRIKLCKDRKCPHGDLTIEGKFVVESVKKYFDLDLENQSVTDSDPRCHFDGKLYHFEKAEGETVYYADVQQASREGKVVNMSGELYNVENKKERPAKFQAVAKPYNWKGKDTWAILSLRTDWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG4</accession>
    <name>D4MAG4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="11" type="ORF">SY1_21050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SGP1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6"/>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21050"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1364"/>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_0"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="163"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="263"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="392"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBL28859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="449" mass="48638" checksum="CE836B233B8CCFAA" modified="2010-05-18" version="1">MKSKRVLFGTDGVRDVANKGGMTPEMALRLGRAFILFMAERGTPKPRIVLGRDTRRSGMMLEGALAAGMTSAGAEVLSLGIIPTPGVSYAVRRLTVDGGAVISASHNPAEYNGIKFLDRDGRKLSDDSELSIEEYIGDNLTDDWRPTGASVGEVRQIPHIVHSYAEHLASMLKDHEATKSGIVFDCAHGAAGTVMPTLIERLNAAWRLIGADPDGMNINEGVGVMHMRHIGNCVTDFGCRIGFAFDGDADRALAVDSRGRVIDGDIILWVLARWLAGEGLLGSGVAMTVMSNIALEEHLKREGVGVFRCPVGDRYVLETMLREGARLGGEQSGHIIADAFTSTGDGLCTALLFLNAVRALGEDVDTLVDRFGRYPQKLSNLTLRSRDRLDLDRINDIAAEAQARMEGRGRIFIRPSGTEPLLRILVEASELSLVEEMSNLLIERLRGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAG5</accession>
    <name>D4MAG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SY1_21070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SGP1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_21070"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1366"/>
    <dbReference type="HOGENOM" id="CLU_048072_3_1_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1273-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBL28860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="313" mass="33646" checksum="96529AE74C46CE25" modified="2010-05-18" version="1">MRLKRLLMELLRFGVSILCLVCAFRGVPLSDLWDLLRQLPPLPIAAAILTSFLAYAAMGVRLMGMRRPRLAFRSTFPASLVGLAVNNVLPAKAGEAAKAAWIGRGAGMKLDEAMGLIFFERFFDVNMLTLLSLWFMVKAEQQRYALPLVACLAAGWLFLLALRARPAWWRRLERLPLPGGLSAFLARFLGAVTAQMTPGRILWMLCSSAALWALYALQVGIVLNGAAGLGLRWTDALGVFALSSLGMLLPSSPGALGVYEAVAVAALTSYGVPRDQALAAALADHMVQFIPVTAAGGLVLLLCPLRGKGQARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D4MAS1</accession>
    <name>D4MAS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SY1_22860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fretibacterium fastidiosum</name>
        <dbReference type="NCBI Taxonomy" id="651822"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Synergistetes</taxon>
            <taxon>Synergistia</taxon>
            <taxon>Synergistales</taxon>
            <taxon>Synergistaceae</taxon>
            <taxon>Fretibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Synergistetes sp. SGP1.</title>
            <authorList>
                <consortium name="metaHIT consortium -- http://www.metahit.eu/"/>
                <person name="Pajon A."/>
                <person name="Turner K."/>
                <person name="Parkhill J."/>
                <person name="Wade W."/>
                <person name="Vartoukian S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pajon A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SGP1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FP929056">
        <property type="protein sequence ID" value="CBL28966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="sbr:SY1_22860"/>
    <dbReference type="PATRIC" id="fig|651822.3.peg.1531"/>
    <dbReference type="HOGENOM" id="CLU_023389_0_0_0"/>
    <dbReference type="BioCyc" id="FFAS651822:G13GF-1382-MON"/>
    <dbReference type="Proteomes" id="UP000008957">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043748">
        <property type="entry name" value="DUF5693"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18949">
        <property type="entry name" value="DUF5693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL28966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008957"/>
        </source>
    </evidence>
    <sequence length="629" mass="67718" checksum="6B6A33DE54F24476" modified="2010-05-18" version="1">MSRRCFLWLTLLFAVACALPGLLPRWRAEGANRTVAIVTDFRSILPLARSAGLSTSEALSRLKGKGLSGLMVSELTGEDLENGIGPAVMLSLRRGAGEGQGTLLSIMPESPHAERLSRWLRIRLVASADALSAGPVTLPIPINMMKNVGVVPDVEGLDAAKEAGLPIFYRPAQTLGWLVANAAAALRATADAYPIAAFAPAGEIVPGYPDVSGLASVSHERDLPVASVEFSRQVGAGALDAAAFPLLLPLHSVTNEELMARNITSRALRERLLRAAVERSVRLLVVRPSPQNMGTATFDDVAQEIAALADTLISHGFTMGWPRPAFGSGWGAAAPWPAVALAALLLLMSWRLAARMNACTSGPIGLRAASFFAASTAVLALLLFKFPAAARLAGAFAAPLVVTEAALTALDFQGRPPLWQRVVEAFGVAVVGGLALAALFSVPSYMLRLKTFSGVKLTLLLPPLLVLVHDLRNRVHPESLTDLLRRPPLWGELLLGGVLLVGLAVMLFRSDNVRFIPGFEARMREFLERLLVARPRSKEVFLGYPCLLLLAFLVKRGLWAQYREVLRIGVVLGFSSVVNSFCHFHTPILFILLREFNGLWTGLLVGALLVAVVRWLMLPLLRTMRPLAE</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>